RIT2

Summary

Gene Symbol: RIT2
Description: Ras like without CAAX 2
Alias: RIBA, RIN, ROC2, GTP-binding protein Rit2, GTP-binding protein Roc2, Ric-like, expressed in neurons, ras-like protein expressed in neurons, ras-like without CAAX protein 2
Species: human
Products:     RIT2

Top Publications

  1. Pankratz N, Beecham G, Destefano A, Dawson T, Doheny K, Factor S, et al. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012;71:370-84 pubmed publisher
    ..71; p=5×10(-8) Combined Sample) (N370; OR=3.08; p=7×10(-5) Replication sample). A novel PD susceptibility locus, RIT2, on chromosome 18 (rs12456492; p=5×10(-5) Discovery Sample; p=1...
  2. Wes P, Yu M, Montell C. RIC, a calmodulin-binding Ras-like GTPase. EMBO J. 1996;15:5839-48 pubmed
    ..Furthermore, we describe two human proteins, RIN and RIT, which were 71% and 66% identical to RIC respectively, shared related G2 domains with RIC, and lacked ..
  3. Shao H, Kadono Okuda K, Finlin B, Andres D. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys. 1999;371:207-19 pubmed
    We report the biochemical characterization of Rit and Rin, two members of the Ras superfamily identified by expression cloning. Recombinant Rit and Rin bind GTP and exhibit intrinsic GTPase activity...
  4. Calissano M, Latchman D. Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. Oncogene. 2003;22:5408-14 pubmed
    ..By using the N-terminal of Brn-3a as the bait, we have repeatedly isolated a protein named Rin, an incompletely characterized small GTP-binding protein expressed only in neurons...
  5. Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. BMC Neurosci. 2005;6:53 pubmed
    ..Using yeast two-hybrid analysis, we identified the neuron-specific and calmodulin-binding Ras-related GTPase Rin as an interaction partner of the intracellular part of B3, but not of B2...
  6. Glessner J, Reilly M, Kim C, Takahashi N, Albano A, Hou C, et al. Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A. 2010;107:10584-9 pubmed publisher
    ..In addition, RET and RIT2, both ras-related genes important for neural crest development, were significantly affected by CNVs...
  7. Lee C, Della N, Chew C, Zack D. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci. 1996;16:6784-94 pubmed
    cDNAs encoding two novel 25 kDa Ras-like proteins, Rit and Rin, were isolated from mouse retina using a degenerate PCR-based cloning strategy. Using the expressed sequence tag database, human orthologs were also obtained and sequenced...
  8. Reuther G, Der C. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol. 2000;12:157-65 pubmed
    ..of the Ras superfamily consists of small GTPases most closely related to Ras and include the R-Ras, Rap, Ral, Rheb, Rin and Rit proteins...
  9. Navaroli D, Stevens Z, Uzelac Z, Gabriel L, King M, Lifshitz L, et al. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci. 2011;31:13758-70 pubmed publisher
    ..In work presented here, we identified the Ras-like GTPase, Rin (for Ras-like in neurons) (Rit2), as a protein that interacts with the DAT C-terminal endocytic signal...

More Information

Publications113 found, 100 shown here

  1. Shi G, Han J, Andres D. Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. J Biol Chem. 2005;280:37599-609 pubmed
    ..Here we defined the Rin GTPase as a novel component of the regulatory machinery contributing to the selective integration of MAP kinase ..
  2. Lai X, Kang X, Zeng L, Li J, Yang Y, Liu D. The protective effects and genetic pathways of thorn grape seeds oil against high glucose-induced apoptosis in pancreatic β-cells. BMC Complement Altern Med. 2014;14:10 pubmed publisher
    ..The rattus pancreatic β-cell line RIN-m5F was treated with/without TGSO which was extracted by supercritical carbon dioxide (CO2) fluid extraction and ..
  3. Ho T, Nateras R, Yan H, Park J, Jensen S, Borges C, et al. A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona. PLoS ONE. 2015;10:e0132831 pubmed publisher
    ..1 (0.8) for papillary RCC, with a 12.5% overall rate of sample disqualification for RIN <7...
  4. Yano R, Nonaka S, Ezura H. Melonet-DB, A Grand RNA-seq Gene Expression Atlas in Melon (Cucumis melo L.). Plant Cell Physiol. 2017;: pubmed publisher
    ..both the tools, we analyzed melon homologs of tomato fruit ripening regulators such as E8, RIPENING-INHIBITOR (RIN) and NON-RIPENING (NOR)...
  5. Singh S, Bhowmick D, Pany S, Joe M, Zaghlula N, Jeremic A. Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells. Biochim Biophys Acta Biomembr. 2018;: pubmed publisher
    ..reduces human amylin-evoked ASK1 and JNK activation and consequently human amylin toxicity in rat insulinoma Rin-m5F cells and human islets...
  6. Parida A, Raghuvanshi U, Pareek A, Singh V, Kumar R, Sharma A. Genome-wide analysis of genes encoding MBD domain-containing proteins from tomato suggest their role in fruit development and abiotic stress responses. Mol Biol Rep. 2018;45:2653-2669 pubmed publisher
    ..The transcript profiling of tomato MBDs in wild-type and two non-ripening mutants, rin and Nr, indicated constructive information regarding their involvement during fruit development...
  7. Morrison F, Miller M, Wolf E, Logue M, Maniates H, Kwasnik D, et al. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019;692:204-209 pubmed publisher
    ..005) with age at death, sex, race and RNA integrity number (RIN) included as covariates...
  8. Guo J, Hu Z, Yu X, Li A, Li F, Wang Y, et al. A histone deacetylase gene, SlHDA3, acts as a negative regulator of fruit ripening and carotenoid accumulation. Plant Cell Rep. 2018;37:125-135 pubmed publisher
    ..expression of ethylene biosynthetic genes (ACS2, ACS4, ACO1 and ACO3) and fruit ripening-associated genes (RIN, E4, E8, PG, Pti4, LOXB, Cnr and TAGL1) in SlHDA3 RNAi lines...
  9. Du L, Xie T, Xu J, Kang A, Di L, Shan J, et al. A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry. J Ethnopharmacol. 2015;174:25-36 pubmed publisher
    ..treatment), RSV group (RSV inoculation/saline treatment), RSV+JOL group (RSV inoculation/JOL treatment), and RSV+Riba group (RSV inoculation/ribavirin treatment)...
  10. Sobue S, Sakata K, Sekijima Y, Qiao S, Murate T, Ichihara M. Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval. Exp Mol Pathol. 2016;100:482-92 pubmed publisher
    ..Interestingly, although the RNA quality was maintained due to high RNA integrity number (RIN) values, up-regulated genes were not validated by quantitative PCR, suggesting that these genes may become ..
  11. Xing Y, Sun W, Wang Y, Gao F, Ma H. Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart. Aging (Albany NY). 2016;8:873-88 pubmed publisher
    ..Young (3 months) and aged (20 months) Sprague Dawley (SD) rats were subjected to MI/Rin vivo. The PHLPP-1 level was higher in aged vs. young hearts at base...
  12. Turpaev K, Welsh N. Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines. Eur J Pharmacol. 2016;784:69-80 pubmed publisher
    ..and ten other aromatic malononitrile compounds (AMN) improves the resistance of insulin-producing βTC6, RIN-5AH, and MIN6 cells to oxidative stress and pro-inflammatory cytokines...
  13. Pelisek J, Hegenloh R, Bauer S, Metschl S, Pauli J, Glukha N, et al. Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank. J Clin Med. 2019;8: pubmed publisher
    ..In order to assess the quality of RNA from FFPE tissue samples over time (2009⁻2018), RNA integrity number (RIN) and the extent of RNA fragmentation were evaluated...
  14. Bergen A, Krasnow R, Javitz H, Swan G, Li M, Baurley J, et al. Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures. BMC Public Health. 2015;15:866 pubmed publisher
    ..All DNA samples had genotype completion rates ≥97.5 %; 68 % of RNA samples yielded RIN scores ≥6.0...
  15. Chen Y, Lan K, Tsai J, Weng T, Yang C, Liu S. Tributyltin exposure at noncytotoxic doses dysregulates pancreatic β-cell function in vitro and in vivo. Arch Toxicol. 2017;91:3135-3144 pubmed publisher
    ..The β-cell-derived RIN-m5F cells and pancreatic islets from mouse and human were treated with TBT (0.05-0.2 μM) for 0.5-4 h...
  16. Tseng A, Chen C, Breslin M, Lan M. Tumor-specific promoter-driven adenoviral therapy for insulinoma. Cell Oncol (Dordr). 2016;39:279-86 pubmed publisher
    ..The efficacy of this vector was tested in insulinoma-derived MIN, RIN, βTC-1 and pancreatic (Panc-1) cells using in vitro cell survival and in vivo tumor growth assays...
  17. Wang R, Yuan X, Meng L, Zhu B, Zhu H, Luo Y, et al. Transcriptome Analysis Provides a Preliminary Regulation Route of the Ethylene Signal Transduction Component, SlEIN2, during Tomato Ripening. PLoS ONE. 2016;11:e0168287 pubmed publisher
    ..proteins, lycopene and aroma biosynthesis, and defense pathway, showed that SlEIN2 influences ripening inhibitor (RIN) in a feedback loop, thus controlling the expression of several other genes...
  18. Uysal H, Chávez Galán L, Vesin D, Blaser G, Benkhoucha M, Ryffel B, et al. Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy. Int J Mol Sci. 2018;19: pubmed publisher
    ..role of TNF and TNF receptors in the control of the inflammatory process associated with Bacillus Calmette-Guérin (BCG)-induced pleurisy...
  19. Chiang K, Yeh C, Pang J, Hsu J, Yeh T, Chen L, et al. 1?,25(OH)2D3 Analog, MART-10, Inhibits Neuroendocrine Tumor Cell Growth Through Induction of G0/G1 Cell-cycle Arrest and Apoptosis. Anticancer Res. 2016;36:3307-13 pubmed
    ..We demonstrated that RIN-m cells, neuroendocrine tumor cells, expressed vitamin D receptor (VDR) and VDR expression increased with ..
  20. Bargalló M, Guardo A, Maleno M, Miralles L, Egaña Gorroño L, Escribà T, et al. Utility of Systematic Isolation of immune cell subsets from HIV-infected individuals for miRNA profiling. J Immunol Methods. 2017;442:12-19 pubmed publisher
    ..Specifically, we show that Bioanalyzer electrophenograms reveal optimal RIN values in HIV positive and negative patients in resting condition (EC:8;HC:6.5;VC:8.80;VP:8;HAART:7...
  21. Glaviano A, Smith A, Blanco A, McLoughlin S, Cederlund M, Heffernan T, et al. A method for isolation of cone photoreceptors from adult zebrafish retinae. BMC Neurosci. 2016;17:71 pubmed
    ..Electropherograms confirmed downstream isolation of high-quality RNA with RNA integrity number (RIN) >7.6 and RNA concentration >5.7 ng/µl obtained from both populations...
  22. Bielskiene K, Bagdoniene L, Mozūraitienė J, Kazbariene B, Janulionis E. E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma. Medicina (Kaunas). 2015;51:1-9 pubmed publisher
    ..Components of different E3 ligases complexes (FBW7, MDM2, RBX1/ROC1, RBX2/ROC2, cullins and many others) are known as oncogenes or tumor suppressors in melanomagenesis...
  23. Mazzaro C, Maso L, Mauro E, Gattei V, Ghersetti M, Bulian P, et al. Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases. Diseases. 2018;6: pubmed publisher
    ..05). Treatments were interferon (IFN) or Pegilated-IFN (PEG-IFN) alone or plus Ribavirin (RIBA) in 101 cases, steroids with or without alkylating agents in 33 cases, Rituximab in 8 patients...
  24. Chen Y, Liao J, Tsai Y, Tsai F. Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes. Oncotarget. 2016;7:39162-39170 pubmed publisher
    ..Transient transfection of human NR4A1 into RIN-m5F and 293T cells caused DNMT1 inhibition and induced insulin receptor activation...
  25. Leaker B, Nicholson G, Ali F, Daudi N, O Connor B, Barnes P. Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway. Respir Res. 2015;16:102 pubmed publisher
    ..High yield of good quality RNA with RNA integrity numbers (RIN) between 7.6 and 9.3 were extracted from the bronchial brushings...
  26. Qin G, Zhu Z, Wang W, Cai J, Chen Y, Li L, et al. A Tomato Vacuolar Invertase Inhibitor Mediates Sucrose Metabolism and Influences Fruit Ripening. Plant Physiol. 2016;172:1596-1611 pubmed
    ..encoding a vacuolar invertase, are directly regulated by the global fruit ripening regulator RIPENING INHIBITOR (RIN). Moreover, we showed that SlVIF physically interacts with SlVI to control Suc metabolism...
  27. Guo J, Hu Z, Li F, Zhang L, Yu X, Tang B, et al. Silencing of histone deacetylase SlHDT3 delays fruit ripening and suppresses carotenoid accumulation in tomato. Plant Sci. 2017;265:29-38 pubmed publisher
    ..reduced and expression of ethylene biosynthetic genes (ACS2, ACS4 and ACO1, ACO3) and ripening-associated genes (RIN, E4, E8, PG, Pti4 and LOXB) was significantly down-regulated in SlHDT3 RNAi lines...
  28. Olaokun O, McGaw L, Janse van Rensburg I, Eloff J, Naidoo V. Antidiabetic activity of the ethyl acetate fraction of Ficus lutea (Moraceae) leaf extract: comparison of an in vitro assay with an in vivo obese mouse model. BMC Complement Altern Med. 2016;16:110 pubmed publisher
    ..The ethyl acetate fraction (10.88 ± 0.55 ?g/L at 250 ?g/ml) enhanced insulin secretion in RIN-m5F pancreatic ?-cells to the same degree as the positive control glibenclamide (11.09 ± 0.07 ?g/L at 1?M)...
  29. Ranjbari A, Azarbayjani M, Yusof A, Halim Mokhtar A, Akbarzadeh S, Ibrahim M, et al. In vivo and in vitro evaluation of the effects of Urtica dioica and swimming activity on diabetic factors and pancreatic beta cells. BMC Complement Altern Med. 2016;16:101 pubmed publisher
    ..The entire pancreas was exposed for histologic examination. The effect of UD on insulin secretion by RIN-5F cells in 6.25 or 12.5 mM glucose dose was examined. Glucose uptake by cultured L6 myotubes was determined...
  30. Seignères B, Descamps F, Croise R, Barlet V, Bouvier Alias M, Chevaliez S, et al. Multicenter clinical evaluation of the new 3rd generation assay for detection of antibodies against hepatitis C virus on the VIDAS(®) system. J Clin Virol. 2016;78:20-6 pubmed publisher
    ..of the samples was determined by using CE-marked immune assays (Architect, AxSym, Prism, Vitros), two immunoblots (RIBA, Inno-Lia) and/or HCV RNA results. Specificity was 99.67% in 10,320 French blood donors without anti-HCV, 99...
  31. Heera R, Sivachandran P, Chinni S, Mason J, Croft L, Ravichandran M, et al. Efficient extraction of small and large RNAs in bacteria for excellent total RNA sequencing and comprehensive transcriptome analysis. BMC Res Notes. 2015;8:754 pubmed publisher
    ..The Phenol-free kit, on the other hand, gave the highest yield and the best quality RNA (RIN value of 9.85 ± 0.3) with good amounts of sRNAs...
  32. Fros J, Geertsema C, Zouache K, Baggen J, Domeradzka N, van Leeuwen D, et al. Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus. Parasit Vectors. 2015;8:464 pubmed publisher
    ..required for localization of CHIKV nsP3 in insect cells and demonstrated its molecular interaction with Rasputin (Rin), the mosquito homologue of G3BP. The biological involvement of Rin in CHIKV infection was investigated in live Ae...
  33. Ru J, Cong Y, Shi D, Lu Y, Niu Y, Xu H. Augmentative locking plate with autologous bone grafting for distal femoral nonunion subsequent to failed retrograde intramedullary nailing. Acta Orthop Traumatol Turc. 2016;50:393-9 pubmed publisher
    ..bone grafting (BG) in treating distal femoral nonunion subsequent to failed retrograde intramedullary nailing (RIN)...
  34. Jouffroy O, Saha S, Mueller L, Quesneville H, Maumus F. Comprehensive repeatome annotation reveals strong potential impact of repetitive elements on tomato ripening. BMC Genomics. 2016;17:624 pubmed publisher
    ..Furthermore, we found that repeats are also present in the proximity of binding sites of the key ripening protein RIN. We also observed that some repeat families are present at unexpected high frequency in the proximity of genes that ..
  35. Li X, Lee S, Yu H, Ye X, Warre R, Liu X, et al. Breaking down barriers: enabling care-by-parent in neonatal intensive care units in China. World J Pediatr. 2017;13:144-151 pubmed publisher
    ..throughout their stay (NICU-NICU group, n=428), admitted to the NICU and then transferred to the Room-In ward (NICU-RIn group, n=1018), or admitted straight to the Room-In ward (RIn only group, n=629)...
  36. Tae B, Kim J, Kang M, Jeong C, Kwak C, Kim H, et al. Prognostic value of impaired estimated glomerular filtration rate in intravesical BCG-treated non-muscle-invasive bladder cancer patients. Sci Rep. 2017;7:1380 pubmed publisher
    ..and comorbities, with a special focus on renal function after intravesical adjuvant bacillus Calmette-Gue´rin (BCG) immunotherapy in patients with non-muscle-invasive bladder cancer (NMIBC)...
  37. Kolijn K, van Leenders G. Comparison of RNA extraction kits and histological stains for laser capture microdissected prostate tissue. BMC Res Notes. 2016;9:17 pubmed publisher
    ..While RNA quality was similar for cresyl violet (median RIN 7.4) and haematoxylin (median RIN 7...
  38. Mohan V, Pandey A, Sreelakshmi Y, Sharma R. Neofunctionalization of Chromoplast Specific Lycopene Beta Cyclase Gene (CYC-B) in Tomato Clade. PLoS ONE. 2016;11:e0153333 pubmed publisher
    ..CARGATCONSENSUS box sequences are required for the binding of the MADS-box regulatory protein RIPENING INHIBITOR (RIN)...
  39. Garceau D, Batson M, Pan I. Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species. Planta. 2017;246:313-321 pubmed publisher
    ..by TAGL1, likely via the ethylene synthesis and signaling pathway and in combination with RIPENING INHIBITOR (RIN)...
  40. Gong S, Schmotzer C, Zhou L. Evaluation of Quantitative Real-Time PCR as a Hepatitis C Virus Supplementary Test After RIBA Discontinuation. J Clin Lab Anal. 2016;30:418-23 pubmed publisher
    ..According to the 2003 CDC guidelines, recombinant immunoblot assay (RIBA) is indispensible to confirm positive screening results and differentiate biologic false positivity from true HCV ..
  41. Rothan H, Bahrani H, Abdulrahman A, Mohamed Z, Teoh T, Othman S, et al. Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo. Antiviral Res. 2016;127:50-6 pubmed publisher
    ..activity against viral replication individually or in combination with the common antiviral drug, Ribavirin (RIBA)...
  42. Jager S, Pallesen L, Vaegter C. Isolation of satellite glial cells for high-quality RNA purification. J Neurosci Methods. 2018;297:1-8 pubmed publisher
    ..The purified RNA shows very little degradation, demonstrated by RNA integrity number (RIN) analysis with an average value of 8...
  43. Navarrete F, García Gutiérrez M, Aracil Fernández A, Lanciego J, Manzanares J. Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease. Neurotherapeutics. 2018;15:459-469 pubmed publisher
    ..To ensure the validity and reliability of gene expression data, the RNA integrity number (RIN) was calculated...
  44. Reck M, Tomasch J, Deng Z, Jarek M, Husemann P, Wagner Döbler I. Stool metatranscriptomics: A technical guideline for mRNA stabilisation and isolation. BMC Genomics. 2015;16:494 pubmed publisher
    ..Next, the influence of the stabilization reagent during sample storage for up to 15 days was studied. RIN analysis and qRT-PCR of spiked-in and indigenous genes revealed that RNA Later preserved mRNA integrity most ..
  45. Bishara A, Hittner J. Confidence intervals for correlations when data are not normal. Behav Res Methods. 2017;49:294-309 pubmed publisher
    ..including Fisher z', two Spearman rank-order methods, the Box-Cox transformation, rank-based inverse normal (RIN) transformation, and various bootstrap methods...
  46. Elitzur T, Yakir E, Quansah L, Zhangjun F, Vrebalov J, Khayat E, et al. Banana MaMADS Transcription Factors Are Necessary for Fruit Ripening and Molecular Tools to Promote Shelf-Life and Food Security. Plant Physiol. 2016;171:380-91 pubmed publisher
    ..E class (SEPALLATA3 [SEP3]) MADS box genes, MaMADS1 and MaMADS2, homologous to the tomato (Solanum lycopersicum) RIN-MADS ripening gene...
  47. Ito Y, Nishizawa Yokoi A, Endo M, Mikami M, Shima Y, Nakamura N, et al. Re-evaluation of the rin mutation and the role of RIN in the induction of tomato ripening. Nat Plants. 2017;3:866-874 pubmed publisher
    Tomato (Solanum lycopersicum) rin mutants completely fail to ripen: they do not produce red pigmentation, soften or induce an ethylene burst...
  48. Gopalakrishna Pillai G, Bharate S, Awasthi A, Verma R, Mishra G, Singh A, et al. Antidiabetic potential of polyherbal formulation DB14201: Preclinical development, safety and efficacy studies. J Ethnopharmacol. 2017;197:218-230 pubmed publisher
    ..mechanism of action of DB14201 could be through increase in glucose uptake and by stimulation of insulin release by RIN-5f cells...
  49. Davila J, Fadra N, Wang X, McDonald A, Nair A, Crusan B, et al. Impact of RNA degradation on fusion detection by RNA-seq. BMC Genomics. 2016;17:814 pubmed
    ..from the 3' end and there is a linear relationship between the coverage decay rate and the RNA integrity number (RIN)...
  50. Orfi Z, Wáczek F, Baska F, Szabadkai I, Torka R, Hartmann J, et al. Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue. Sci Rep. 2017;7:44073 pubmed publisher
    ..that some commercially available TKIs and many novel synthesized analogues were able to induce insulin secretion in RIN-5AH beta cells. Our aim was to find efficient, more selective and less toxic compounds...
  51. Zhang J, Hu Z, Yao Q, Guo X, Nguyen V, Li F, et al. A tomato MADS-box protein, SlCMB1, regulates ethylene biosynthesis and carotenoid accumulation during fruit ripening. Sci Rep. 2018;8:3413 pubmed publisher
    ..immature green to B + 7 (7 days after Breaker) fruits in the wild type (WT) and was lower in Nr and rin mutants fruits...
  52. Bauman A, Valverde I, Fischer C, Vomstein S, Mindt T. Development of 68Ga- and 89Zr-Labeled Exendin-4 as Potential Radiotracers for the Imaging of Insulinomas by PET. J Nucl Med. 2015;56:1569-74 pubmed publisher
    ..Both radiotracers were evaluated in vitro with RIN-m5F cells for their cell internalization properties as well as affinities and specificities toward the glucagonlike ..
  53. Breitel D, Chappell Maor L, Meir S, Panizel I, Puig C, Hao Y, et al. AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening. PLoS Genet. 2016;12:e1005903 pubmed publisher
    ..ARF2A expression is ripening regulated and reduced in the rin, nor and nr ripening mutants...
  54. Nagai K, Araki D, Matsushita T, Nishizawa Y, Hoshino Y, Matsumoto T, et al. Biomechanical Function of Anterior Cruciate Ligament Remnants: Quantitative Measurement With a 3-Dimensional Electromagnetic Measurement System. Arthroscopy. 2016;32:1359-66 pubmed publisher
    ..as being attached to the posterior cruciate ligament (PCL group), to the roof of the intercondylar notch (RIN group), to the lateral wall of the intercondylar notch (LWIN group), or as having no substantial remnants (NONE ..
  55. Constantinescu A, Abbas M, Kassem M, Gleizes C, Kreutter G, Schini Kerth V, et al. Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. Mol Cell Biochem. 2016;418:91-102 pubmed publisher
    ..Human exocrine PANC-1 and rat endocrine insulin-secreting RIN-m5F cells and isolated rat islets were submitted to 1-100 nM TAC or SIR...
  56. Aarem J, Brunborg G, Aas K, Harbak K, Taipale M, Magnus P, et al. Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank. BMC Res Notes. 2016;9:430 pubmed publisher
    ..High-quality blood-RNAs with average RIN-values above seven were extracted using all five RNA isolation protocols...
  57. Zhang B, Tieman D, Jiao C, Xu Y, Chen K, Fei Z, et al. Chilling-induced tomato flavor loss is associated with altered volatile synthesis and transient changes in DNA methylation. Proc Natl Acad Sci U S A. 2016;113:12580-12585 pubmed
    ..RNAs encoding transcription factors essential for ripening, including RIPENING INHIBITOR (RIN), NONRIPENING, and COLORLESS NONRIPENING are reduced in response to chilling and may be responsible for reduced ..
  58. de Moraes M, Desai P, Porwollik S, Canals R, Perez D, Chu W, et al. Salmonella Persistence in Tomatoes Requires a Distinct Set of Metabolic Functions Identified by Transposon Insertion Sequencing. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Fitness reduction of the Salmonella amino acid synthesis mutants was generally more severe in the tomato rin mutant, which hyperaccumulates certain amino acids, suggesting that these nutrients remain unavailable to ..
  59. Lalmahomed Z, Coebergh van den Braak R, Oomen M, Arshad S, Riegman P, Ijzermans J. Multicenter fresh frozen tissue sampling in colorectal cancer: does the quality meet the standards for state of the art biomarker research?. Cell Tissue Bank. 2017;18:425-431 pubmed publisher
    ..of intact RNA is sufficient for molecular discovery research and prove SOP compliance, the RNA integrity number (RIN) was determined. Samples with a RIN < 6 were measured a second time and when consistently low a third time...
  60. Shukla V, Upadhyay R, Tucker M, Giovannoni J, Rudrabhatla S, Mattoo A. Transient regulation of three clustered tomato class-I small heat-shock chaperone genes by ethylene is mediated by SlMADS-RIN transcription factor. Sci Rep. 2017;7:6474 pubmed publisher
    ..expressed at MG fruit stage in two different tomato genotypes as well as in their ripening mutants, including rin, nor and Nr, and an ethylene-deficient transgenic line, ACS2-antisense...
  61. Varshney R, Gupta S, Roy P. Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic ?-cell death through modulation of autophagy via AMPK/mTOR signaling pathway. Mol Cell Endocrinol. 2017;448:1-20 pubmed publisher
    ..The data showed that kaempferol treatment increased cell viability and anti-apoptotic activity in PA-stressed RIN-5F cells and murine pancreatic islets...
  62. Yu K, Xing J, Zhang J, Zhao R, Zhang Y, Zhao L. Effect of multiple cycles of freeze-thawing on the RNA quality of lung cancer tissues. Cell Tissue Bank. 2017;18:433-440 pubmed publisher
    ..RNA integrity was assessed by using an Agilent bioanalyzer to obtain RNA integrity numbers (RIN)...
  63. Imperiale A, Boisson F, Kreutter G, Goichot B, Namer I, Bachellier P, et al. O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) uptake in insulinoma: first results from a xenograft mouse model and from human. Nucl Med Biol. 2017;53:21-28 pubmed publisher
    ..sup>18F-FDOPA PET were performed on tumor-bearing nude mice after subcutaneous injection of RIN-m5F murine beta cells and on a 30-year-old man with type-1 multiple endocrine neoplasia and hyperinsulinemic ..
  64. Yusoff N, Lim V, Al Hindi B, Abdul Razak K, Widyawati T, Anggraini D, et al. Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats. Nutrients. 2017;9: pubmed publisher
    ..The pancreatic effect of AE was further studied through RIN-5F cell culture, which revealed a positive stimulatory effect on insulin release at a basal glucose concentration (..
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    GWAS meta-analysis identified RIT2 rs12456492 and STX1B rs4889603 as PD susceptible loci...
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    ..When exposed to cytotoxic levels of MG for 48 h, RIN-m5F ?-cells exhibited a significant loss of viability and impaired insulin secretion, whereas pretreatment with ..
  67. Karakoc A, Berkem R, Irmak H, Demiroz A, Yenicesu I, Ertugrul N, et al. Investigation of an algorithm for anti HCV EIA reactivity in blood donor screening in Turkey in the absence of nucleic acid amplification screening. Transfus Apher Sci. 2017;56:732-737 pubmed publisher
    ..0 and Radim HCV Ab. All the repeat reactive samples were tested by INNO-LIA HCV Ab 3.0 or Chiron RIBA HCV 3.0 and Abbott Real Time HCV. Intra-assay correlations were calculated with Pearson r test...
  68. Pawlus R, Breuer S, Virte M. Relative intensity noise reduction in a dual-state quantum-dot laser by optical feedback. Opt Lett. 2017;42:4259-4262 pubmed publisher
    We report a reduction of the relative intensity noise (RIN) in a dual-state emitting quantum-dot laser subject to the state-selective optical feedback on the ground state and excited state...
  69. Hoshino M, Nakamura S. The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. Biochem Biophys Res Commun. 2002;295:651-6 pubmed
    A novel 25 K Ras-like protein, Rin, binds calmodulin in a Ca2+-dependent manner and is considered to participate in a calcium/calmodulin-mediated signaling pathway. However, little is known about Rin signaling mechanism...
  70. Wang J, Bansal A, Martin M, Germer S, Benayed R, Essioux L, et al. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. Pharmacogenomics J. 2013;13:235-41 pubmed publisher
    ..This study suggests that it is unlikely that a major genetic determinant of response exists, and it illustrates the complexity of performing genome-wide association scans in clinical trials. ..
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    Recently, a meta-analysis including 5 large genome-wide association studies has identified rs12456492 variant of RIT2 gene as a novel risk locus for Parkinson's disease (PD) in Caucasian populations...
  72. Lu Y, Liu W, Tan K, Peng J, Zhu Y, Wang X. Genetic association of RIT2 rs12456492 polymorphism and Parkinson's disease susceptibility in Asian populations: a meta-analysis. Sci Rep. 2015;5:13805 pubmed publisher
    Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson's disease (PD) are controversial...
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    ..We conclude that Ras-activated endocytosis is facilitated, in part, by the ability of Ras to directly regulate the Rab5 nucleotide exchange activity of RIN1. ..
  74. Fan J, Chen W, Gu C, Song Y, Chai L, Wang C, et al. Noise characteristics of high power fiber-laser pumped femtosecond optical parametric generation. Opt Express. 2017;25:24594-24603 pubmed publisher
    We study, both numerically and experimentally, the relative intensity noise (RIN) and timing jitter characteristics of optical parametric generation (OPG) process in MgO-doped periodically poled LiNbO3 (MgO:PPLN) pumped by ..
  75. Kasai K, Nakazawa M, Tomomatsu Y, Endo T. 1.5?m, mode-hop-free full C-band wavelength tunable laser diode with a linewidth of 8 kHz and a RIN of -130 dB/Hz and its extension to the L-band. Opt Express. 2017;25:22113-22124 pubmed publisher
    ..A relative intensity noise (RIN) below -130 dB/Hz was simultaneously achieved over the C-band range...
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    Excess relative intensity noise (RIN) constitutes one of the major limitations of most spectroscopic methods involving lasers. Here, we present an active RIN suppression scheme for a coherent mid-infrared (MIR) light source (8...
  77. Liu Z, Guo J, Wang Y, Li K, Sun Q, Xu Q, et al. Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China. Neurobiol Aging. 2015;36:1600.e9-11 pubmed publisher
    ..of genome-wide association studies in Parkinson's disease (PD) has identified the rs12456492 variant in RIT2 as a new susceptibility loci...
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    Many published case-control studies have investigated the association between rs12456492(A/G) variant in RIT2 gene and the risk of Parkinson's disease(PD); however, an ambiguous conclusion remains elusive...
  79. Wang X, Qiao Z, Liu J, Zheng M, Liu W, Wu C. Stereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes. Xenobiotica. 2017;:1-9 pubmed publisher
    ..was to investigate the underlying mechanism of the stereoselectivity in the metabolism of rhynchophylline (RIN) and isorhynchophylline (IRN) epimers in rat liver microsomes (RLM). 2...
  80. Do C, Tung J, Dorfman E, Kiefer A, Drabant E, Francke U, et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet. 2011;7:e1002141 pubmed publisher
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    Recent several meta-analyses and certain case-control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson's disease (PD) in Asian and Caucasian populations...
  82. Foo J, Tan L, Irwan I, Au W, Low H, Prakash K, et al. Genome-wide association study of Parkinson's disease in East Asians. Hum Mol Genet. 2017;26:226-232 pubmed publisher
    ..We also identified significant (P?<?0.05) associations at 5 loci (DLG2, SIPA1L2, STK39, VPS13C and RIT2), and observed the same direction of associations at 9 other loci including BST1 and PARK16...
  83. Wang X, Zheng M, Liu J, Huang Z, Bai Y, Ren Z, et al. Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats. J Ethnopharmacol. 2017;209:175-183 pubmed publisher
    ..Rhynchophylline (RIN) and isorhynchophylline (IRN), a pair of epimers, are major alkaloids isolated from U...
  84. Kim D, Zhang S, Kwon D, Liao R, Cui Y, Zhang Z, et al. Intensity noise suppression in mode-locked fiber lasers by double optical bandpass filtering. Opt Lett. 2017;42:4095-4098 pubmed publisher
    We show that the relative intensity noise (RIN) of a mode-locked fiber laser can be suppressed below a -140??dB/Hz level for the entire >20??Hz offset frequency range by a proper combination of intra-cavity and extra-cavity optical ..
  85. Shahzad M, Shahid N, Sial N, Hasanat A, Khalid M, Yousaf M, et al. Evaluation of DNA vaccines encoding M. Tb gene Bfrb and Mpt32 in mice model. Pak J Pharm Sci. 2017;30:2025-2029 pubmed
    ..Mycobacterium bovis based Bacille Calmette-Gue´rin (BCG) is the only vaccine available against TB however, this (single) vaccine is not enough to eradicate it...
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    ..studies of Parkinson's disease (PD) have identified the rs12456492 variant of the novel susceptibility loci, RIT2, as being associated with disease risk in a large white population. Studies among Asians are scarce...
  87. Chang P, Peng H, Zhang S, Chen Z, Luo B, Chen J, et al. A Faraday laser lasing on Rb 1529 nm transition. Sci Rep. 2017;7:8995 pubmed publisher
    ..Both the laser linewidth and relative intensity noisy (RIN) are measured...
  88. McGovern F, Boland T, Ryan M, Sweeney T. Assessment of RNA Stability in Postmortem Tissue from New-Born Lambs. Anim Biotechnol. 2017;:1-7 pubmed publisher
    ..Postmortem sampling time resulted in variable reductions in the relative integrity number (RIN) values across the tissues, ranging from 0.9 to 1.8% in liver, spleen, skeletal muscle, and ileum to 5.7-11...
  89. Sandoval A, Duran P, Gandini M, Andrade A, Almanza A, Kaja S, et al. Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway. Cell Calcium. 2017;66:1-9 pubmed publisher
    ..Here, we show that native L-type channels in the insulin-secreting RIN-m5F cell line, and recombinant CaV1...
  90. Lin L, Liu S, Lin F. Stability of period-one (P1) oscillations generated by semiconductor lasers subject to optical injection or optical feedback. Opt Express. 2017;25:25523-25532 pubmed publisher
    ..Moreover, excess P1 linewidth broadening in the OI scheme caused by fluctuation in injection parameters associated with frequency jitter and relative intensity noise (RIN) is also minimized in the OF scheme.
  91. Gallazzi F, Rizzelli G, Iqbal M, Tan M, Harper P, Ania Castañon J. Performance optimization in ultra-long Raman laser amplified 10×30 GBaud DP-QPSK transmission: balancing RIN and ASE noise. Opt Express. 2017;25:21454-21459 pubmed publisher
    We experimentally evaluate the influence of RIN transfer from pump to signal on the transmission performance of a 10 × 30 Gbaud DP-QPSK transmission system using a 2nd-order ultra-long Raman fiber laser amplifier, considering the effect ..
  92. Tanaka H, Sasaki H. Cognitive impairment with interferon treatment in patients with chronic hepatitis C. Biomed Res. 2017;38:371-374 pubmed publisher
    ..Subjects were 20 patients with chronic hepatitis C; 13 patients were treated with peg IFN-?2b and ribavirin (riba group), and 7 patients were treated with peg IFN-?2a (alone group)...