Gene Symbol: RIP140
Description: nuclear receptor interacting protein 1
Alias: RIP140, nuclear receptor-interacting protein 1, nuclear factor RIP140, receptor-interacting protein 140
Species: human
Products:     RIP140

Top Publications

  1. Tazawa H, Osman W, Shoji Y, Treuter E, Gustafsson J, Zilliacus J. Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Mol Cell Biol. 2003;23:4187-98 pubmed
    ..Receptor-interacting protein 140 (RIP140) is a corepressor that negatively regulates the ligand-induced activity of several nuclear receptors, including ..
  2. Carascossa S, Gobinet J, Georget V, Lucas A, Badia E, Castet A, et al. Receptor-interacting protein 140 is a repressor of the androgen receptor activity. Mol Endocrinol. 2006;20:1506-18 pubmed
    ..In the present study, we investigated the regulation of AR activity by the receptor-interacting protein 140 (RIP140). We first showed that RIP140 could be coimmunoprecipitated with the receptor when coexpressed in 293T cells...
  3. Heim K, Gamsby J, Hever M, Freemantle S, Loros J, Dunlap J, et al. Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140. PLoS ONE. 2009;4:e7639 pubmed publisher
    ..Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregulator that represses the transactivation of agonist-bound nuclear receptors...
  4. Subramaniam N, Treuter E, Okret S. Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. J Biol Chem. 1999;274:18121-7 pubmed
    ..While some of the NR-associated proteins serve as coactivators, the effect of the receptor interacting protein 140 (RIP140) on NR transcriptional responses is complex...
  5. Lee C, Wei L. Characterization of receptor-interacting protein 140 in retinoid receptor activities. J Biol Chem. 1999;274:31320-6 pubmed
    Receptor-interacting protein 140 (RIP140) contains multiple receptor interaction domains and interacts with retinoic acid receptors in a ligand-dependent manner...
  6. Wei L, Hu X, Chandra D, Seto E, Farooqui M. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem. 2000;275:40782-7 pubmed
    Receptor-interacting protein 140 (RIP140) encodes a histone deacetylase (HDAC) inhibitor-sensitive repressive activity...
  7. Vo N, Fjeld C, Goodman R. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. Mol Cell Biol. 2001;21:6181-8 pubmed
    ..In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself...
  8. Carroll J, Liu X, Brodsky A, Li W, Meyer C, Szary A, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005;122:33-43 pubmed
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells. ..
  9. Docquier A, Harmand P, Fritsch S, Chanrion M, Darbon J, Cavailles V. The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes. Clin Cancer Res. 2010;16:2959-70 pubmed publisher
    Receptor-interacting protein of 140 kDa (RIP140) is a transcriptional cofactor for nuclear receptors involved in reproduction and energy homeostasis...

More Information

Publications157 found, 100 shown here

  1. Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson J. A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol. 1998;12:864-81 pubmed
    ..receptor-alpha (PPAR alpha) as bait in a yeast two-hybrid screening, we have isolated nuclear factor RIP140 whose function in receptor activation is unclear...
  2. Hu X, Chen Y, Farooqui M, Thomas M, Chiang C, Wei L. Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation. J Biol Chem. 2004;279:319-25 pubmed
    Gene induction by retinoic acid (RA) is suppressed by overexpression of receptor-interacting protein 140 (RIP140)...
  3. Christian M, Tullet J, Parker M. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. J Biol Chem. 2004;279:15645-51 pubmed
    ..We have characterized four distinct autonomous repression domains in RIP140, termed RD1-4, that are highly conserved in mammals and birds...
  4. Heim K, White K, Deng D, Tomlinson C, Moore J, Freemantle S, et al. Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. Mol Cancer. 2007;6:57 pubmed
    ..b>RIP140 (also called NRIP1) is a ligand-dependent corepressor that is inducible with retinoic acid (RA)...
  5. Heery D, Kalkhoven E, Hoare S, Parker M. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 1997;387:733-6 pubmed
    ..We propose that the LXXLL motif is a signature sequence that facilitates the interaction of different proteins with nuclear receptors, and is thus a defining feature of a new family of nuclear proteins. ..
  6. Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J. Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. Mol Endocrinol. 2001;15:501-11 pubmed
    ..In this study, we show that 14--3-3 interacts with the nuclear receptor corepressor RIP140. In transfection assays, RIP140 antagonizes 14--3-3- enhanced GR transactivation...
  7. Cavailles V, Dauvois S, L Horset F, Lopez G, Hoare S, Kushner P, et al. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 1995;14:3741-51 pubmed
    ..We have characterized a novel nuclear protein, RIP140, that specifically interacts in vitro with this domain of the estrogen receptor...
  8. Kumar M, Tarpey R, Perdew G. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem. 1999;274:22155-64 pubmed
    ..The role of coactivator, RIP140, in the modulation of transcriptional activity of AhR/ARNT heterodimer was examined...
  9. White K, Yore M, Deng D, Spinella M. Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid. J Biol Chem. 2005;280:7829-35 pubmed
    The receptor interacting protein 140 (RIP140) belongs to a unique subclass of nuclear receptor coregulators with the ability to bind and repress the action of a number of agonist-bound hormone receptors...
  10. Madak Erdogan Z, Katzenellenbogen B. Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140. Toxicol Sci. 2012;125:401-11 pubmed publisher
    ..ERα, AhR, aryl hydrocarbon receptor translocator, and receptor interacting protein 140 (RIP140) were recruited to gene regulatory regions in a gene-specific and E2/dioxin ligand-specific ..
  11. Triki M, Lapierre M, Cavailles V, Mokdad Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol. 2017;23:4480-4490 pubmed publisher
  12. Fritah A, Steel J, Nichol D, Parker N, Williams S, Price A, et al. Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function. Cardiovasc Res. 2010;86:443-51 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a ligand-dependent cofactor for nuclear receptors that regulate networks of genes involved in cellular processes, including metabolism...
  13. Piao H, Chu X, Lv W, Zhao Y. Involvement of receptor-interacting protein 140 in estrogen-mediated osteoclasts differentiation, apoptosis, and bone resorption. J Physiol Sci. 2017;67:141-150 pubmed publisher
    ..Taken together, receptor-interacting protein 140 might be a critical player in estrogen-mediated osteoclastogenesis and bone resorption. ..
  14. Feng X, Yu W, Liang R, Shi C, Zhao Z, Guo J. [Effects of receptor-interacting protein 140 gene over-expression on the migration and proliferation of neuroblastoma cells]. Zhonghua Yi Xue Za Zhi. 2014;94:2540-3 pubmed
    ..The N2a RIP140 over-expression model (N2a-rip140) was constructed by lipofection and validated by real-time polymerase chain ..
  15. You J, Yue Z, Chen S, Chen Y, Lu X, Zhang X, et al. Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes. Acta Physiol (Oxf). 2017;220:58-71 pubmed publisher
    The transcriptional cofactor receptor-interacting protein 140 (RIP140) is known as a deleterious regulator of cardiac mitochondrial function and energy metabolic homeostasis...
  16. Blondrath K, Steel J, Katsouri L, Ries M, Parker M, Christian M, et al. The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation. Neurobiol Aging. 2016;47:180-191 pubmed publisher
    The receptor interacting protein-140 (RIP140) is a cofactor for several nuclear receptors and has been involved in the regulation of metabolic and inflammatory genes...
  17. Müller K, Sixou S, Kuhn C, Jalaguier S, Mayr D, Ditsch N, et al. Prognostic relevance of RIP140 and ERβ expression in unifocal versus multifocal breast cancers: a preliminary report. Int J Mol Sci. 2019;20: pubmed publisher
    ..The aim of this study was to investigate the expression of two nuclear receptor transcriptional coregulators, namely RIP140 (receptor-interacting protein of 140 kDa) and LCoR (ligand-dependent corepressor) in unifocal versus multifocal ..
  18. Chang S, Tsao Y, Lin C, Chen S. NRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein. J Virol. 2011;85:6750-63 pubmed publisher
    ..We present evidences for E2 phosphorylation in vivo and show that NRIP acts as a scaffold to recruit E2 and calcium/calmodulin to prevent polyubiquitination and degradation of E2, enhancing E2 stability and E2-driven gene expression. ..
  19. Gibson W, Hoivik E, Halle M, Taylor Weiner A, Cherniack A, Berg A, et al. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat Genet. 2016;48:848-55 pubmed publisher
    ..These data demonstrate extensive genetic heterogeneity in endometrial cancers and relative homogeneity across metastatic sites. ..
  20. Takayama K, Suzuki T, Fujimura T, Urano T, Takahashi S, Homma Y, et al. CtBP2 modulates the androgen receptor to promote prostate cancer progression. Cancer Res. 2014;74:6542-53 pubmed publisher
    ..corepressor, CtBP2 repressed tumor-suppressor genes and AR corepressors in prostate cancer cells, such as NCOR and RIP140, by binding with AR to the promoter enhancers of these genes...
  21. Hu F, Wang M, Xiao T, Yin B, He L, Meng W, et al. miR-30 promotes thermogenesis and the development of beige fat by targeting RIP140. Diabetes. 2015;64:2056-68 pubmed publisher
    ..miR-30b/c targets the 3'-untranslated region of the receptor-interacting protein 140 (RIP140), and overexpression of miR-30b/c significantly reduced RIP140 expression...
  22. Sixou S, Müller K, Jalaguier S, Kuhn C, Harbeck N, Mayr D, et al. Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival. Transl Oncol. 2018;11:1090-1096 pubmed publisher
    ..Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen receptors, strongly ..
  23. Castet A, Herledan A, Bonnet S, Jalaguier S, Vanacker J, Cavailles V. Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol. 2006;20:1035-47 pubmed
    We have investigated the effects of receptor-interacting protein 140 (RIP140) on transcriptional regulation by estrogen receptor-related receptors (ERRs)...
  24. Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, et al. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Nucleic Acids Res. 2004;32:1957-66 pubmed
    ..deacetylases (HDACs) in the repressive activity of the nuclear receptor cofactor Receptor-Interacting Protein 140 (RIP140)...
  25. Xue J, Zhao H, Shang G, Zou R, Dai Z, Zhou D, et al. RIP140 is associated with subclinical inflammation in type 2 diabetic patients. Exp Clin Endocrinol Diabetes. 2013;121:37-42 pubmed publisher
    To evaluate the expression level of RIP140 (receptor interaction protein 140) and its correlation with inflammatory cytokine production and free fatty acids (FFAs) in type 2 diabetes...
  26. Zhuang H, Wang X, Zha D, Gan Z, Cai F, Du P, et al. FADD is a key regulator of lipid metabolism. EMBO Mol Med. 2016;8:895-918 pubmed publisher
    ..We show that FADD interacts with RIP140, which is a corepressor for PPAR-α, and FADD phosphorylation-mimic mutation (FADD-D) or FADD deficiency abolishes ..
  27. Li J, Liu Z. [Comparison of efficiency and cytotoxicity of different transfection reagents in transfecting RIP140-siRNA into Kupffer cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1694-700 pubmed
    To compare the efficiency and cytotoxicity of different transfection reagents used in transfection of RIP140-siRNA into Kupffer cells to optimize the transfection conditions...
  28. Chen Y, Chen S, Yue Z, Zhang Y, Zhou C, Cao W, et al. Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats. Transl Res. 2017;180:91-102.e1 pubmed publisher
    Heart failure (HF) is associated with myocardial energy metabolic abnormality. Receptor-interacting protein 140 (RIP140) is an important transcriptional cofactor for maintaining energy balance in high-oxygen consumption tissues...
  29. Imajo M, Kondoh K, Yamamoto T, Nakayama K, Nakajima Koyama M, Nishida E. Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells. Mol Cell Biol. 2017;37: pubmed publisher
    ..suppression results from the inhibition of RAR transcriptional activity, which is shown to be mediated through an RIP140/histone deacetylase (HDAC)-mediated mechanism...
  30. Shen Y, Cohen J, Nicoloro S, Kelly M, Yenilmez B, Henriques F, et al. CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. J Biol Chem. 2018;293:17291-17305 pubmed publisher
    ..We conclude that CriPs offer an effective Cas9 and sgRNA delivery system for ablating targeted gene products in cultured cells and in vivo, providing a potential therapeutic strategy for metabolic disease. ..
  31. Lin Y, Montassier E, Knights D, Wei L. Gut microbiota from metabolic disease-resistant, macrophage-specific RIP140 knockdown mice improves metabolic phenotype and gastrointestinal integrity. Sci Rep. 2016;6:38599 pubmed publisher
    ..metabolic diseases due to enhanced anti-inflammation engineered by lowering receptor interacting protein (RIP140) expression in macrophage...
  32. Miotto P, Frendo Cumbo S, Sacco S, Wright D, Ward W, Holloway G. Combined high-fat-resveratrol diet and RIP140 knockout mice reveal a novel relationship between elevated bone mitochondrial content and compromised bone microarchitecture, bone mineral mass, and bone strength in the tibia. Mol Nutr Food Res. 2016;60:1994-2007 pubmed publisher
    ..A molecular model of elevated mitochondrial content (RIP140 knock out (KO) mice) was utilized to determine proof-of-principle that increasing mitochondrial content coincides ..
  33. Huttala O, Mysore R, Sarkanen J, Heinonen T, Olkkonen V, Ylikomi T. Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes. Cell Tissue Res. 2016;366:63-74 pubmed publisher
    ..per cell and adipocyte-specific gene expression (PPAR?, adiponectin, AP2, leptin, Glut4, Prdm16, CIDEA, PGC1-?, RIP140, UCP and ADCY5)...
  34. Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, et al. Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization. Bioorg Med Chem. 2018;26:5099-5117 pubmed publisher
    ..Cofactor recruitment assay showed that several cofactors, such as RIP140 and PGC1, were significantly recruited, whereas several canonical factors was not affected...
  35. Windahl S, Treuter E, Ford J, Zilliacus J, Gustafsson J, McEwan I. The nuclear-receptor interacting protein (RIP) 140 binds to the human glucocorticoid receptor and modulates hormone-dependent transactivation. J Steroid Biochem Mol Biol. 1999;71:93-102 pubmed
    ..the mechanism of transcriptional activation by the GR by studying the role of the receptor interacting protein RIP140. Both in vivo and in vitro protein-protein interaction assays revealed a ligand-dependent interaction between the ..
  36. Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002;277:19649-57 pubmed
    ..These results suggest that the activity of PPARgamma antagonists can be modulated by the availability and concentration of RXR agonists. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function. ..
  37. Nakao R, Yamamoto S, Horikawa K, Yasumoto Y, Nikawa T, Mukai C, et al. Atypical expression of circadian clock genes in denervated mouse skeletal muscle. Chronobiol Int. 2015;32:486-96 pubmed publisher
    ..Our findings revealed that sciatic denervation disrupts the circadian expression of clock and clock-controlled genes either directly or indirectly via muscle atrophy in the gastrocnemius muscles of mice in a gene-specific manner. ..
  38. Lin Y, Tsai H, Liu P, Benneyworth M, Wei L. Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response. Cell Death Dis. 2017;8:3203 pubmed publisher
    ..Here, we found that RIP140, a wide-spectrum cofactor of nuclear hormone receptors, acts as a co-repressor of heat shock factor 1 (HSF1) to ..
  39. Wei L, Hu X. Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. Mol Cell Endocrinol. 2004;218:39-48 pubmed
    Over-expression of receptor interacting protein 140 (RIP140) suppressed thyroid hormone (T3) induction of cellular retinoic acid binding I protein (CRABPI) gene in P19 embryonal carcinoma cells...
  40. Katsanis N, Ives J, Groet J, Nizetic D, Fisher E. Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998;102:221-3 pubmed
    ..1 and 21q22.3. Here, we report the mapping of the gene for receptor interacting protein 140 (RIP140) on 21q11 by means of YACs, PACs and hybrid cell lines...
  41. Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, et al. Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Mol Endocrinol. 2007;21:1581-92 pubmed
    ..adipocytes derived from brown or white adipose tissue devoid of the nuclear receptor corepressor receptor interacting protein 140 (RIP140)...
  42. Feng X, Yu W, Liang R, Shi C, Zhao Z, Guo J. Receptor-interacting protein 140 overexpression promotes neuro-2a neuronal differentiation by ERK1/2 signaling. Chin Med J (Engl). 2015;128:119-24 pubmed publisher
    ..Receptor-interacting protein 140 (RIP140) is significantly upregulated in DS brains, suggesting its involvement in DS CNS development abnormalities...
  43. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, et al. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015;290:14418-29 pubmed publisher
    ..induced LXRα expression and LXRα/β nuclear translocation while inhibiting expression of receptor interacting protein 140 (RIP140), an LXR co-repressor...
  44. Yang J, Shi Y, Chen H, Wang X, Chen Y, Yang B. Glycyrrhizic acid attenuates myocardial injury: Involvement of RIP140/NF-kB Pathway. Biomed Pharmacother. 2017;95:62-67 pubmed publisher
    ..Meanwhile, it should be noted that GA restored RIP140/NF-kB in rat hearts which was evidenced by the western Blot analysis...
  45. Zhang R, Kim Y, Yang X, Li Y, Li S, Lee J. A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient. Cancer Genet. 2011;204:687-91 pubmed publisher
    ..To our knowledge, this is the first description of possible genes involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation. ..
  46. Eirin A, Riester S, Zhu X, Tang H, Evans J, O BRIEN D, et al. MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells. Gene. 2014;551:55-64 pubmed publisher
    ..These observations may contribute to development of regenerative strategies using EVs to overcome potential complications of cell-based therapy. ..
  47. Wang H, Su S, Wang Y, Chang S, Liao K, Lo H, et al. MicroRNA-134 Contributes to Glucose-Induced Endothelial Cell Dysfunction and This Effect Can Be Reversed by Far-Infrared Irradiation. PLoS ONE. 2016;11:e0147067 pubmed publisher
    ..Detection of miR-134 expression in FIR-treated ECFCs should help us to explore further the effectiveness of FIR therapy. ..
  48. Kakehashi A, Stefanov V, Ishii N, Okuno T, Fujii H, Kawai K, et al. Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. Int J Mol Sci. 2017;18: pubmed publisher
    ..In STAM mice, PPARs inhibition was not obvious, while expression of cytokeratins 8 and 18 was elevated, indicative of essential differences between human and mouse NASH pathogenesis. ..
  49. Morabito F, Cutrona G, Mosca L, D Anca M, Matis S, Gentile M, et al. Surrogate molecular markers for IGHV mutational status in chronic lymphocytic leukemia for predicting time to first treatment. Leuk Res. 2015;39:840-5 pubmed publisher
    ..3, 95% CI: 1.1-4.9, P=.027) and MBOAT1 (HR=2.1, 95% CI: 1.1-3.7, P=.018) retained their independent prognostic impact, supporting the hypothesis that these genes may potentially act as surrogates for predicting IGHV mutational status. ..
  50. Li N, Rowley S, Thompson E, McInerny S, Devereux L, Amarasinghe K, et al. Evaluating the breast cancer predisposition role of rare variants in genes associated with low-penetrance breast cancer risk SNPs. Breast Cancer Res. 2018;20:3 pubmed publisher
  51. Lin Y, Liu P, Adhikari N, Hall J, Wei L. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. J Mol Cell Cardiol. 2015;79:287-94 pubmed publisher
    ..Here we identified a protein, RIP140 (receptor interacting protein 140), which enhances macrophage-derived foam cell formation by reducing expression of reverse cholesterol ..
  52. Chen C, Chen M, Wu C, Lin C, Chern S, Wu P, et al. Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 21q11.2-q21.1 and a literature review. Taiwan J Obstet Gynecol. 2017;56:554-557 pubmed publisher
    ..2q21.1). aCGH is useful for identification of the nature and genetic component of a prenatally detected sSMC. ..
  53. Koppen A, Houtman R, Pijnenburg D, Jeninga E, Ruijtenbeek R, Kalkhoven E. Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009;8:2212-26 pubmed publisher
    ..These findings indicate that NR-coregulator interaction profiling may be a useful tool for drug development and biological discovery. ..
  54. Shalev M, Aviram R, Adamovich Y, Kraut Cohen J, Shamia T, Ben Dor S, et al. The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions. Nucleic Acids Res. 2014;42:11879-90 pubmed publisher
  55. Herbst E, Bonen A, Holloway G. Changes in nuclear receptor corepressor RIP140 do not influence mitochondrial content in the cortex. Appl Physiol Nutr Metab. 2015;40:1086-8 pubmed publisher
    Changes in nuclear receptor interacting protein 140 (RIP140) influences mitochondrial content in skeletal muscle; however, the translation of these findings to the brain has not been investigated...
  56. Stouth D, vanLieshout T, Shen N, Ljubicic V. Regulation of Skeletal Muscle Plasticity by Protein Arginine Methyltransferases and Their Potential Roles in Neuromuscular Disorders. Front Physiol. 2017;8:870 pubmed publisher
    ..such as peroxisome proliferator-activated receptor-? coactivator-1?, E2F transcription factor 1, receptor interacting protein 140, and the tumor suppressor protein p53, are putative downstream targets of PRMTs that regulate muscle ..
  57. Lopez G, Webb P, Shinsako J, Baxter J, Greene G, Kushner P. Titration by estrogen receptor activation function-2 of targets that are downstream from coactivators. Mol Endocrinol. 1999;13:897-909 pubmed
    ..p160 coactivators, SRC1a and GRIP1 (glucocorticoid receptor interacting protein 1), or the putative corepressor, RIP140. Finally TR action becomes more potent when coactivator levels are raised...
  58. Chung H. RIP140, a Janus metabolic switch involved in defense functions. Cell Mol Immunol. 2013;10:7-9 pubmed publisher
  59. He Y, Zhang L, Li Z, Gao H, Yue Z, Liu Z, et al. RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor. FEBS Lett. 2015;589:455-60 pubmed publisher
    Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown...
  60. Coşkun S, Yucel Y, Cim A, Cengiz B, Oztuzcu S, Varol S, et al. Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population. J Genet. 2016;95:131-40 pubmed
    ..In addition, variant GG genotype of rs2229741 may reduce the risk of migraine in Turkish women. ..
  61. Lin Y, Liu P, Pook K, Wei L. Glyburide and retinoic acid synergize to promote wound healing by anti-inflammation and RIP140 degradation. Sci Rep. 2018;8:834 pubmed publisher
    ..anti-inflammatory effect, which is to stimulate the degradation of a pro-inflammatory regulator, Receptor Interacting Protein 140 (RIP140), by activating Ca2+/calmodulin-dependent protein kinase II (CamKII) that triggers specific ..
  62. Mu Q, Yu W, Zheng S, Shi H, Li M, Sun J, et al. RIP140/PGC-1α axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function. Artif Cells Nanomed Biotechnol. 2018;46:806-816 pubmed publisher
    ..A can regulate the morphology and function of mitochondria in its induction of neural differentiation through the RIP140/PGC-1α axis are unclear...
  63. Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, et al. KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Cell Rep. 2016;16:2373-86 pubmed publisher
    ..This complex recruits the corepressor RIP140 instead of the coactivator SRC1, resulting in reduced Srebf1 and thus downstream lipogenic enzyme expression ..
  64. Madak Erdogan Z, Charn T, Jiang Y, Liu E, Katzenellenbogen J, Katzenellenbogen B. Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators. Mol Syst Biol. 2013;9:676 pubmed publisher
    ..for differing response specification by related TFs, we show that these TFs and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules...
  65. Hemmings K, Daniel Z, Buttery P, Parr T, Brameld J. Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle. Animal. 2015;9:285-94 pubmed publisher
    ..The results suggest that the two agents work via different mechanisms or over different timescales, with only BA inducing changes in muscle mass and transitions to a faster, less oxidative fibre type after a 6-day treatment. ..
  66. Saksa N, Neme A, Ryynänen J, Uusitupa M, de Mello V, Voutilainen S, et al. Dissecting high from low responders in a vitamin D3 intervention study. J Steroid Biochem Mol Biol. 2015;148:275-82 pubmed publisher
    ..This article is part of a Special Issue entitled '17th Vitamin D Workshop' . ..
  67. Lapierre M, Castet Nicolas A, Gitenay D, Jalaguier S, Teyssier C, Bret C, et al. Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia. J Hematol Oncol. 2015;8:20 pubmed publisher
    b>RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles...
  68. Hellal Levy C, Fagart J, Souque A, Wurtz J, Moras D, Rafestin Oblin M. Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor. Mol Endocrinol. 2000;14:1210-21 pubmed
  69. Nautiyal J, Steel J, Mane M, Oduwole O, Poliandri A, Alexi X, et al. The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013;140:1079-89 pubmed publisher
    Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth ..
  70. Xia K, Zhang P, Hu J, Hou H, Xiong M, Xiong J, et al. Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells. Oncol Lett. 2018;15:4344-4350 pubmed publisher
    ..In addition, receptor-interacting protein 140 (RIP140) has been observed to inhibit the Wnt/β-catenin signaling pathway and cell growth...
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    ..The high-mutation frequency combined with the expression data suggest, for the first time, an involvement of NRIP1 in endometrial cancer development. ..
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    b>Nuclear receptor interacting protein 1 (NRIP1) is an important energy regulator, but few studies have addressed its role in humans...
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    Receptor-interacting protein 140 (RIP140) is highly expressed in the brain, and acts in neurons and microglia to affect emotional responses...
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    ..receptor (PPAR)γ coactivator-1α (PGC-1α), PPARδ, and receptor-interacting protein 140 (RIP140), as well as that of the dystrophin-homolog, utrophin A...
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    ..RXR for binding to PPREs as well as to common co-activators, such as RIP-140. Our results suggest an important role for TAK1 in modulating PPARalpha-controlled gene expression in hepatocytes. ..
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    ..transcriptional activity of the coactivator, probably by enhancing the interaction of PGC-1alpha with corepressor RIP140. Mutation that abolished the SUMOylation augments the activity of PGC-1alpha also in the context of PPARgamma-..
  77. Fritah A, Steel J, Parker N, Nikolopoulou E, Christian M, Carling D, et al. Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK. PLoS ONE. 2012;7:e32520 pubmed publisher
    ..b>RIP140 is a transcriptional coregulator with a central role in metabolic tissues and we tested the effect of modulating ..
  78. Xiang X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, et al. Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch. Diabetes. 2015;64:519-28 pubmed publisher
    ..for brown adipocyte determination, was significantly decreased, while mRNAs for retinoblastoma protein, p107 and RIP140, the transcriptional factors for white adipocyte determination, increased in the BAT of Fabp4-Tsc1(-/-) mice...
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    ..Our observations provide novel insights in the potential actions of visfatin in BAT. ..
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    The mouse homologue of the human receptor-interacting protein 140 (RIP140) was isolated from a mouse embryonic cDNA library in yeast two-hybrid screening experiments by using the ligand binding domain (LBD) of nuclear orphan receptor TR2 ..
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    ..While RIP140 is known to modulate proinflammatory cytokine production during an inflammatory response, its role in ALI/ARDS is ..
  82. Mouchon A, Delmotte M, Formstecher P, Lefebvre P. Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA. Mol Cell Biol. 1999;19:3073-85 pubmed
    ..element core motifs spacing defined the relative affinity of liganded heterodimers for two NCoAs, SRC-1 and RIP140. hRXRalpha activating function 2 was critical to confer hRARalpha full responsiveness but not differential ..
  83. Rytinki M, Palvimo J. SUMOylation modulates the transcription repressor function of RIP140. J Biol Chem. 2008;283:11586-95 pubmed publisher
    b>RIP140/NRIP1 (receptor-interacting protein 140) functions as a corepressor of nuclear receptors. It plays an important role in the transcriptional control of energy metabolism and female fertility...
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    b>Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation...
  85. Izzo A, Manco R, Bonfiglio F, Cali G, De Cristofaro T, Patergnani S, et al. NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome. Hum Mol Genet. 2014;23:4406-19 pubmed publisher
    ..available expression data related to manipulation of chromosome 21 (Hsa21) genes suggested the nuclear receptor interacting protein 1 (NRIP1 or RIP140) as a good candidate Hsa21 gene for NEMG downregulation...
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    ..binding protein alpha (C/EBPα), cell death-inducing dFF45-like effector c (Cidec) and receptor interacting protein 140 (RIP140)...
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    ..of the AF-1 domain rendered TR4 a repressor, mediated through the preferential recruitment of corepressor RIP140. Dephosphorylation of its AF-1 made TR4 an activator due to its selective recruitment of coactivator, P300/cyclic ..
  90. Caplan J, Kumar A, Park E, Padmanabhan M, Hoban K, Modla S, et al. Chloroplast Stromules Function during Innate Immunity. Dev Cell. 2015;34:45-57 pubmed publisher
    ..These results support a model in which stromules aid in the amplification and/or transport of pro-defense signals into the nucleus and other subcellular compartments during immunity. ..
  91. Xie C, Wu B, Xi J, Wang R, Zhang C, Li Y, et al. [Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-?B pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1467-1471 pubmed
    ..The protein levels of receptor interacting protein140 (RIP140), Toll-like receptor 4 (TLR4), p-NF-?Bp65, NF-?Bp65, p-I?B? and I?B? in the liver were detected by Western blot ..
  92. Mostaqul Huq M, Gupta P, Tsai N, White R, Parker M, Wei L. Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J. 2006;25:5094-104 pubmed
    b>Receptor interacting protein 140 (RIP140), a ligand-dependent corepressor for nuclear receptors, can be modified by arginine methylation...