Gene Symbol: RIMS2
Description: regulating synaptic membrane exocytosis 2
Alias: OBOE, RAB3IP3, RIM2, regulating synaptic membrane exocytosis protein 2, RAB3 interacting protein 3, Rab3-interacting protein, non-small cell lung cancer RimL3a protein, non-small cell lung cancer RimL3c protein, nuclear protein, rab-3-interacting molecule 2, rab-3-interacting protein 3, rab3-interacting molecule 2
Species: human
Products:     RIMS2

Top Publications

  1. Lai K, Kweon S, Chi F, Hwang E, Kabe Y, Higashiyama R, et al. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017;152:1477-1491 pubmed publisher
    ..This loop required MUFA inhibition of binding of Ras-related nuclear protein 1 (Ran1) to transportin 1 and reduced nuclear import of elav-like protein 1 (HuR), increasing cytosolic ..
  2. Chen J, Jayachandran M, Xu B, Yu Z. Sea bass (Lateolabrax maculatus) accelerates wound healing: A transition from inflammation to proliferation. J Ethnopharmacol. 2019;236:263-276 pubmed publisher
    ..The phosphorylation and nuclear protein levels of transcription factor nuclear factor-κB (NF-ĸB) in toll-like receptor 4 (TLR4) signaling were ..
  3. Ghosh M, Öner D, Poels K, Tabish A, Vlaanderen J, Pronk A, et al. Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. Nanotoxicology. 2017;:1-16 pubmed publisher
    ..methyltransferase-1 (DNMT1) and histone deacetylase 4 (HDAC4)], DNA damage/repair and cell cycle pathways [nuclear protein, coactivator of histone transcription/ATM serine/threonine kinase (NPAT/ATM)], and a potential transforming ..
  4. Zhang Y, Guo H, Cheng B, Su T, Fu X, Li T, et al. Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther. 2018;12:2731-2748 pubmed publisher
    ..Phosphorylation and nuclear protein levels of transcription factors (activator protein-1 [AP-1], NF-κB, interferon regulatory factor 3 [IRF3]) ..
  5. Raucci A, Di Maggio S, Scavello F, D Ambrosio A, Bianchi M, Capogrossi M. The Janus face of HMGB1 in heart disease: a necessary update. Cell Mol Life Sci. 2019;76:211-229 pubmed publisher
    High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription regulation, DNA replication and repair and nucleosome assembly...
  6. Ge L, Zhu M, Yang J, Wang F, Zhang R, Zhang J, et al. Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression. Pharmacol Biochem Behav. 2015;131:77-86 pubmed publisher
    ..following treatment with oleamide, including GSTA4, glutathione S-transferase A6 (GSTA6), GTP-binding nuclear protein Ran (Ran-GTP), ATP synthase subunit d, transgelin-3, small ubiquitin-related modifier 2 (SUMO2), and ..
  7. Godwin A, Yang W, Sharma A, Khader A, Wang Z, Zhang F, et al. Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury. Shock. 2015;43:24-30 pubmed publisher
    Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis...
  8. Lane R, Fu Y, Matsuzaki S, Kinter M, Humphries K, Griffin T. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther. 2015;17:54 pubmed publisher
    ..b>Nuclear protein expression and gene expression of HIF-2α, a transcription factor for SOD2, were significantly ..
  9. Morita S, Furube E, Mannari T, Okuda H, Tatsumi K, Wanaka A, et al. Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. Cell Tissue Res. 2015;359:865-84 pubmed publisher
    ..Immunohistochemistry of bromodeoxyuridine and Ki-67, a nuclear protein that is associated with cellular proliferation, revealed active proliferation of endothelial cells...

More Information

Publications154 found, 100 shown here

  1. Song C, He L, Zhang J, Ma H, Yuan X, Hu G, et al. Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1?/IL-1R1/MyD88/NF-?B pathway. J Cell Mol Med. 2016;20:2064-2077 pubmed publisher
    ..The expression of nuclear protein p65 was measured by Western blot...
  2. Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H. Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway. Drug Des Devel Ther. 2019;13:647-655 pubmed publisher
    ..Western blot was used to detect the expression of Caspase-3, Bax, Bcl-2, HO-1, Nrf2, Akt, p-Akt and nuclear protein Nrf2...
  3. Gates K, Goetzmann L, Cantlon J, Jeckel K, Anthony R. Effect of proline rich 15-deficiency on trophoblast viability and survival. PLoS ONE. 2017;12:e0174976 pubmed publisher
    ..Proline rich 15 (PRR15) is a low molecular weight nuclear protein expressed by the trophoblast during early gestation...
  4. Mou K, Liu W, Han D, Li P. HMGB1/RAGE axis promotes autophagy and protects keratinocytes from ultraviolet radiation-induced cell death. J Dermatol Sci. 2017;85:162-169 pubmed publisher
    ..High-mobility group protein 1 (HMGB1) is a highly conserved nuclear protein that is associated with cell autophagy...
  5. Ragni M, Wu W, Liang X, Hsieh C, Cortese Hassett A, Lu L. Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse model. Exp Hematol. 2009;37:744-54 pubmed publisher
    ..VIII. When mice were pretreated with 2 x 10(6) F.VIII-pulsed immature DCre (deficient nuclear factor-kappaB nuclear protein binding, low CD80, low CD86, high interleukin [IL]-10 phenotype) 7 days before rF.VIII challenge, anti-F...
  6. Park M, Lee S, Lee S, Kim E, Lee E, Moon Y, et al. GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation. J Transl Med. 2016;14:206 pubmed publisher
    ..Gene associated with retinoid-interferon-induced mortality (GRIM) 19, originally identified as a nuclear protein, is expressed ubiquitously in various human tissues and regulate signal transducer and activator of ..
  7. Liu Z, Jeppesen P, Gregersen S, Larsen L, Hermansen K. Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse islets. J Endocrinol. 2012;215:79-88 pubmed publisher
    ..g. collapsin response mediator protein 2 and GTP-binding nuclear protein Ran), insulin signal transduction (proteasome subunit α type 6), and the oxidative phosphorylation pathway (..
  8. Xu Z, Zheng G, Wu C, Jiang X, Zou S. Identification of proteins differentially expressed in the gills of grass carp (Ctenopharyngodon idella) after hypoxic stress by two-dimensional gel electrophoresis analysis. Fish Physiol Biochem. 2019;: pubmed publisher
    ..of the toll-like receptor 4, ephx1 protein, isocitrate dehydrogenase, L-lactate dehydrogenase, GTP-binding nuclear protein Ran, and glyceraldehyde-3-phosphate dehydrogenase; however, the expression of the keratin type II ..
  9. Bermudez J, Webber H, Patel G, Liu X, Cheng Y, Clark A, et al. HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGF?2 in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2016;57:3698-707 pubmed publisher
    ..Total and nuclear proteins, RNA, and nuclear protein-DNA complexes were harvested for WB, quantitative PCR (qPCR), and chromatin immunoprecipitation (ChIP) assays,..
  10. Wang X, Ibrahim Y, Das D, Zungu Edmondson M, Shults N, Suzuki Y. Carfilzomib reverses pulmonary arterial hypertension. Cardiovasc Res. 2016;110:188-99 pubmed publisher
    ..The cell death role of autophagy was promoted by the participation of tumour protein p53-inducible nuclear protein 1...
  11. GÅ‚ombik K, Stachowicz A, Åšlusarczyk J, Trojan E, Budziszewska B, Suski M, et al. Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats. Psychoneuroendocrinology. 2015;60:151-62 pubmed publisher
    ..component subunit beta, the voltage-dependent anion-selective channel protein 2 (VDAC2), and the GTP-binding nuclear protein RAN (RAN) were down-regulated and the expression of phosphatidylethanolamine-binding protein 1 (PEBP-1) was ..
  12. Bosch P, Fuller L, Sleeth C, Weiner J. Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016;11:21 pubmed
    ..We show that the gene encoding Akirin2, a small nuclear protein, is expressed in the embryonic telencephalon...
  13. de la Tremblaye P, Benoit S, Schock S, Plamondon H. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Prog Neuropsychopharmacol Biol Psychiatry. 2017;79:234-248 pubmed publisher
    ..neuronal death and inflammation were determined by analyzing immunoreactivity (ir) of neuron-specific nuclear protein (NeuN), microglia (IBA1, ionized calcium binding adaptor molecule 1), astrocytes (GFAP, glial fibrillary ..
  14. Kuster D, Merkus D, Blonden L, Kremer A, van Ijcken W, Verhoeven A, et al. Gene reprogramming in exercise-induced cardiac hypertrophy in swine: A transcriptional genomics approach. J Mol Cell Cardiol. 2014;77:168-74 pubmed publisher
    ..5-fold (P<0.01), respectively. In DNA-binding assays, using LV nuclear protein extracts and protein/DNA array, signal intensity changes >2-fold were observed for 23 TF-specific DNA ..
  15. Camer D, Yu Y, Szabo A, Dinh C, Wang H, Cheng L, et al. Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet. Mol Cell Endocrinol. 2015;412:36-43 pubmed publisher
    ..protein levels and TNFα mRNA expression, and increased nuclear factor-like 2 (Nrf2) mRNA expression and nuclear protein levels...
  16. Qiu Y, Chen Y, Zeng T, Guo W, Zhou W, Yang X. High-mobility group box-B1 (HMGB1) mediates the hypoxia-induced mesenchymal transition of osteoblast cells via activating ERK/JNK signaling. Cell Biol Int. 2016;40:1152-1161 pubmed publisher
    High-mobility group box 1 (HMGB1) is a nuclear protein that involves the binding with DNA and influences chromatin regulation and transcription...
  17. Ebrahimkhani M, Daneshmand A, Mazumder A, Allocca M, Calvo J, Abolhassani N, et al. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A. 2014;111:E4878-86 pubmed publisher
    ..NAD and ATP levels plus the translocation and extracellular release of the high-mobility group box 1 (Hmgb1) nuclear protein, activating the sterile inflammatory response...
  18. Jyotsna V, Malik E, Birla S, Sharma A. Novel MEN 1 gene findings in rare sporadic insulinoma--a case control study. BMC Endocr Disord. 2015;15:44 pubmed publisher
    ..MEN1 encodes a nuclear protein Menin, a tumor suppressor which acts as an adapter and interacts with partner proteins involved in crucial ..
  19. Hong S, Yoo J, Bose S, Park J, Han K, Kim S, et al. Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray. J Transl Med. 2015;13:331 pubmed publisher
    ..synthase 2, G0/G1 switch 2, carcinoembryonic antigen-related cell adhesion molecule 3, cystein-serine-rich nuclear protein 1, and interleukin 8 receptor, alpha which were highly expressed in LDS obesity constitution...
  20. Manna D, Ehrenkaufer G, Singh U. Regulation of gene expression in the protozoan parasite Entamoeba invadens: identification of core promoter elements and promoters with stage-specific expression patterns. Int J Parasitol. 2014;44:837-45 pubmed publisher
    ..Electrophoretic mobility shift assays demonstrated that both motifs specifically bind nuclear protein(s) from E. invadens trophozoites...
  21. Jones J, Singh P, Govind C. Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide. PLoS ONE. 2016;11:e0148897 pubmed publisher
    Cmr1 (changed mutation rate 1) is a largely uncharacterized nuclear protein that has recently emerged in several global genetic interaction and protein localization studies...
  22. Maatough A, Whitfield G, Brook L, Hsieh D, Palade P, Hsieh J. Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers. J Cell Biochem. 2018;119:69-80 pubmed publisher
    ..how HR mutations may be contributing to alopecia as well as to cancer, and, finally, outline future directions in the study of this largely enigmatic nuclear protein. J. Cell. Biochem. 119: 69-80, 2018. © 2017 Wiley Periodicals, Inc.
  23. Wang M, Zhao J, Sun D, Meng X, Sun G, Sun X. [Protective effects and underlying mechanisms of Panax notoginseng saponins against SH-SY5Y cell apoptosis induced by 6-hydroxydopamine]. Yao Xue Xue Bao. 2016;51:898-906 pubmed
    ..The activation of caspase-3 was measured with the caspase-3 assay kit. The expression of nuclear protein Nrf2 and HO-1 were determined by Western blot...
  24. Peleg R, Romzova M, Kogan Zviagin I, Apte R, Priel E. Modification of topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors. BMC Cancer. 2014;14:910 pubmed publisher
    ..b>Nuclear protein extracts were prepared and topoisomerases activity and protein levels were determined...
  25. Dai S, Hou J, Long Y, Wang J, Li C, Xiao Q, et al. Widespread and evolutionary analysis of a MITE family Monkey King in Brassicaceae. BMC Plant Biol. 2015;15:149 pubmed publisher
    ..A fragment containing putative TATA-box motifs in the MITE sequence could bind with nuclear protein(s) extracted from leaves of B. napus plants...
  26. Yang W, Ng F, Chan K, Pu X, Poston R, Ren M, et al. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genet. 2016;12:e1006127 pubmed publisher
    ..reporter gene assays showed that a short DNA sequence encompassing the rs4773144 site interacted with a nuclear protein, with lower efficiency for the G allele, and that the G allele sequence had lower activity in driving ..
  27. Rajan P, Dalgliesh C, Bourgeois C, Heiner M, Emami K, Clark E, et al. Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. BMC Cell Biol. 2009;10:82 pubmed publisher
    ..hnRNP L protein was predominantly present within small nuclear protein complexes approximating to the expected size of monomers and dimers, and was quantitatively associated with ..
  28. Khan D, Katoch A, Das A, Sharathchandra A, Lal R, Roy P, et al. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell Death Differ. 2015;22:1203-18 pubmed publisher
    ..Surprisingly, we found scaffold/matrix attachment region-binding protein 1 (SMAR1), a predominantly nuclear protein is abundant in the cytoplasm under glucose deprivation...
  29. Zhao G, Yang W, Wu J, Chen B, Yang X, Chen J, et al. Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
    ..An electrophoretic mobility shift assay exhibited preferential binding of a nuclear protein to the risk allele...
  30. Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, et al. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Mol Cell Biol. 2016;36:407-20 pubmed publisher
    ..decipher the molecular mechanisms underlying NRF2-dependent transcriptional activation, we purified the NRF2 nuclear protein complex and identified the Mediator subunits as NRF2 cofactors...
  31. Zherebiatiev A, Kamyshnyi A. Expression Levels of Proinflammatory Cytokines and NLRP3 Inflammasome in an Experimental Model of Oxazolone-induced Colitis. Iran J Allergy Asthma Immunol. 2016;15:39-45 pubmed
    ..High-mobility group box 1 (HMGB1) is a nuclear protein regulating the expression of these proinflammatory cytokines...
  32. Chen B, Yi S, Wang W, He Y, Huang Y, Gao Z, et al. Transcriptome comparison reveals insights into muscle response to hypoxia in blunt snout bream (Megalobrama amblycephala). Gene. 2017;624:6-13 pubmed publisher
    ..Interesting, four genes, heat shock protein beta-8 (hspb8), cysteine/serine-rich nuclear protein 1 (csrnp1), salt-inducible kinase 1 (sik1), and visinin-like 1a (vsnl1a) were up-regulated in MT Vs MC but ..
  33. Ylikallio E, Woldegebriel R, Tumiati M, Isohanni P, Ryan M, Stark Z, et al. MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability. Brain. 2017;140:2093-2103 pubmed publisher
    ..We report mutations in the gene MCM3AP, encoding the germinal center associated nuclear protein (GANP), in nine affected individuals from five unrelated families...
  34. Eclov R, Kim M, Smith R, Ahituv N, Kroetz D. Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity. Drug Metab Dispos. 2018;46:636-642 pubmed publisher
    ..Electrophoretic mobility shift assays confirmed a reduction in nuclear protein binding to the rs59370292 variant probe, whereas the rs76656413 probe had a shift in transcription factor ..
  35. Lund Iversen M, Grøholt K, Helland Ã, Borgen E, Brustugun O. NUT expression in primary lung tumours. Diagn Pathol. 2015;10:156 pubmed publisher
    b>Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19...
  36. Castro J, Araya G, Inostroza P, Hidalgo P, González Ramos R, Sovino H, et al. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation. Biol Res. 2015;48:56 pubmed publisher
    ..Our objective was to study the nuclear protein contents of upstream stimulating factor 2 (USF2a and USF2b), a positive regulator of SF-1, throughout the ..
  37. Chadha N, Jaggi A, Silakari O. Structure-based design of new poly (ADP-ribose) polymerase (PARP-1) inhibitors. Mol Divers. 2017;21:655-660 pubmed publisher
    Poly (ADP-ribose) polymerase (PARP-1) is a well-established nuclear protein with prominent role in signaling and DNA repair. Various clinical candidates have been identified with the role in PARP-1 inhibition...
  38. Ji H, Wang Y, Cloix C, Li K, Jenkins G, Wang S, et al. The Arabidopsis RCC1 Family Protein TCF1 Regulates Freezing Tolerance and Cold Acclimation through Modulating Lignin Biosynthesis. PLoS Genet. 2015;11:e1005471 pubmed publisher
    ..Here, we report that a specifically cold-induced nuclear protein, Tolerant to Chilling and Freezing 1 (TCF1), interacts with histones H3 and H4 and associates with chromatin ..
  39. Sun Y, Chakrabartty A. Phase to Phase with TDP-43. Biochemistry. 2017;56:809-823 pubmed publisher
    TDP-43 is a dimeric nuclear protein that plays a central role in RNA metabolism...
  40. Masuda D, Masuda R, Matsuzaki T, Imamura N, Aruga N, Tanaka M, et al. Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma. Mol Med Rep. 2015;12:7303-9 pubmed publisher
    Ki-67 is a nuclear protein that is expressed during the G1, S, G2 and M phases of the mitotic cell cycle...
  41. Mukherjee S, Sengupta Bandyopadhyay S. Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M. Cytokine. 2016;88:209-213 pubmed publisher
    ..Following initial hours of PMA treatment, a nuclear protein C/EBP-β binds specifically to the CCAAT consensus sequence at the proximal end of the OSM promoter...
  42. Seabra C, Szoko N, Erdin S, Ragavendran A, Stortchevoi A, Maciel P, et al. A novel microduplication of ARID1B: Clinical, genetic, and proteomic findings. Am J Med Genet A. 2017;173:2478-2484 pubmed publisher
    ..of membranes, organelles, and vesicles; (2) aspects of cell cycle control, signal transduction, and nuclear protein export; (3) ubiquitination and proteosomal function; and (4) aspects of mRNA synthesis/splicing...
  43. Rush P, Rosenbaum J, Roy M, Baus R, Bennett D, Lloyd R. INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma). J Cutan Pathol. 2017;: pubmed publisher
    ..INSM1 is a transcription factor expressed in tissues undergoing terminal NE differentiation. As a nuclear protein tied both to differentiation and the cell-cycle, INSM1 may offer additional utility in comparison to ..
  44. Sidik S, Huet D, Lourido S. CRISPR-Cas9-based genome-wide screening of Toxoplasma gondii. Nat Protoc. 2018;13:307-323 pubmed publisher
    ..We recently used CRISPR-Cas9 to disrupt all nuclear protein-coding genes in T. gondii using a pooled format...
  45. Harms A, Herpel E, Pfarr N, Penzel R, Heussel C, Herth F, et al. NUT carcinoma of the thorax: Case report and review of the literature. Lung Cancer. 2015;90:484-91 pubmed publisher
    NUT (nuclear protein in testis) carcinomas are exceedingly rare neoplasms with specific molecular alterations and often follow a devastating course. Thus, a precise early diagnosis is of utmost importance...
  46. Gatz S, Salles D, Jacobsen E, Dörk T, Rausch T, Aydin S, et al. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child. Hum Mutat. 2016;37:257-68 pubmed publisher
    ..Two de novo mutated candidate genes, MCM3AP encoding germinal center-associated nuclear protein (GANP) and POMP encoding proteasome maturation protein (POMP), were identified by whole-exome sequencing (WES)..
  47. Ma X, Turnbull P, Crapper E, Wang H, Drannik A, Jiang F, et al. Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice. Histochem Cell Biol. 2016;145:545-59 pubmed publisher
    NeuN is a nuclear protein expressed exclusively in mature neurons and has served for many years as a reliable neuronal marker in immunohistochemical labeling studies...
  48. Lonial S. Treatment of MM: Upcoming Novel Therapies. Cancer Treat Res. 2016;169:195-205 pubmed
    ..targets, such as kinesin spindle protein (KSP) inhibitors, cyclin dependent kinase (CDK) inhibitors, and nuclear protein export inhibitors...
  49. Mori H, Murakami M, Tsuda T, Kameda K, Utsunomiya R, Masuda K, et al. Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes. J Dermatol Sci. 2018;90:154-165 pubmed publisher
    High mobility group box 1 (HMGB1) is a nuclear protein that stabilizes DNA and facilitates gene transcription...
  50. Zhou L, Bai Y, Li Y, Liu X, Tan T, Meng S, et al. Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncol Lett. 2016;11:365-372 pubmed
    Microcephalin (MCPH1/BRIT1) is a large nuclear protein that is involved in the early cellular response to DNA damage, the expression of which is reduced in a variety of types of human tumors...
  51. Boatti L, Rapallo F, Viarengo A, Marsano F. Toxic effects of mercury on the cell nucleus of Dictyostelium discoideum. Environ Toxicol. 2017;32:417-425 pubmed publisher
    ..and, since mercury is able to induce oxidative stress that could bring to protein aggregation, we assessed nuclear protein carbonylation by Western Blot...
  52. Tang Y, Yan G, Song X, Wu K, Li Z, Yang C, et al. STIP overexpression confers oncogenic potential to human non-small cell lung cancer cells by regulating cell cycle and apoptosis. J Cell Mol Med. 2015;19:2806-17 pubmed publisher
    Sip1/tuftelin-interacting protein (STIP), a multidomain nuclear protein, is a novel factor associated with the spliceosome, yet its role and molecular function in cancer remain unknown...
  53. Basenko E, Kamei M, Ji L, Schmitz R, Lewis Z. The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa. PLoS Genet. 2016;12:e1005790 pubmed publisher
    ..MUS-30 is a nuclear protein, consistent with its predicted role as a chromatin remodeling enzyme, and levels of MUS-30 are increased ..
  54. Sun Z, Zhou M, Dan Wang -, Tang Y, Lin M, Wu Y. Overexpression of the Lotus corniculatus Soloist Gene LcAP2/ERF107 Enhances Tolerance to Salt Stress. Protein Pept Lett. 2016;23:442-9 pubmed
    ..A subcellular localization experiment indicated that LcAP2/ERF107 is a nuclear protein that activates transcription...
  55. Yarosh C, Tapescu I, Thompson M, Qiu J, Mallory M, Fu X, et al. TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells. Nucleic Acids Res. 2015;43:9006-16 pubmed publisher
    PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential nuclear protein with important roles in DNA damage repair and RNA biogenesis...
  56. Li Y, Song Y, Zhao M, Guo Y, Yu C, Chen W, et al. A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2. Hepatology. 2017;66:481-497 pubmed publisher
    ..CRTC2 reduced the nuclear protein expression of forkhead box O1 and subsequently increased SREBP-2 transcription by binding insulin response ..
  57. Stevens N, Chapman M, Fraser C, Kuchel T, Hayball J, Diener K. Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes. Sci Rep. 2017;7:5850 pubmed publisher
    ..b>Nuclear protein high mobility group box protein 1 (HMGB1) is released following cell death and is a late mediator in sepsis ..
  58. Nikić Spiegel I. Genetic Code Expansion- and Click Chemistry-Based Site-Specific Protein Labeling for Intracellular DNA-PAINT Imaging. Methods Mol Biol. 2018;1728:279-295 pubmed publisher
    ..As an example, I show click-PAINT imaging of vimentin and low-abundance nuclear protein, nucleoporin 153.
  59. Gerard H, Whittum Hudson J, Schumacher H, Hudson A. Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection. Ann Rheum Dis. 2006;65:321-7 pubmed
  60. Wang Y, Jin G, Li Q, Wang Z, Hu W, Li P, et al. Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma. J Cancer. 2016;7:2067-2076 pubmed
    ..that pro-inflammatory cytokines, TNF-? and IL-1?, could up-regulate the expression of GLI1 gene, increase its nuclear protein expression and promote malignant cell behaviors including migration, invasion, epithelial-mesenchymal ..
  61. Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
    Damaged DNA-binding protein 2 (DDB2), a nuclear protein, participates in both nucleotide excision repair and mRNA transcription. The transcriptional regulatory function of DDB2 is significant in colon cancer, as it regulates metastasis...
  62. Jia T, Zhang B, You C, Zhang Y, Zeng L, Li S, et al. The Arabidopsis MOS4-Associated Complex Promotes MicroRNA Biogenesis and Precursor Messenger RNA Splicing. Plant Cell. 2017;29:2626-2643 pubmed publisher
    ..As a nuclear protein, MAC7 is not concentrated in dicing bodies, but it affects the localization of HYPONASTIC LEAVES1 (HYL1), a ..
  63. Yoo J, Lim T, Park J, Hah Y, Park N, Hong S, et al. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. J Dermatol Sci. 2013;72:246-51 pubmed publisher
    ..These results suggest that SYT14L, especially its C2 domain, may play an important role in regulating melanocyte differentiation through the modulation of ERK and (or) CREB signaling. ..
  64. Pike J, Meyer M, Benkusky N, Lee S, St John H, Carlson A, et al. Genomic Determinants of Vitamin D-Regulated Gene Expression. Vitam Horm. 2016;100:21-44 pubmed publisher
    ..1,25(OH)2D3) to the regulation of gene expression has evolved extensively since the initial discovery of a nuclear protein known as the vitamin D receptor (VDR)...
  65. Mariggiò G, Koch S, Zhang G, Weidner Glunde M, Rückert J, Kati S, et al. Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. PLoS Pathog. 2017;13:e1006335 pubmed publisher
    ..Although LANA is mainly a nuclear protein, cytoplasmic isoforms of LANA exist and can act as antagonists of the cytoplasmic DNA sensor, cGAS...
  66. Ponnusamy M, Zhuang M, Zhou X, Tolbert E, Bayliss G, Zhao T, et al. Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. J Pharmacol Exp Ther. 2015;354:142-51 pubmed publisher
    ..However, SRT1720 treatment did not affect expression of proliferating cell nuclear protein, a proliferation marker and activation of extracellular signal regulated kinase 1/2 in vitro and in vivo...
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    ..By these results, the discovery of a new inducer and the interesting activity of a blend of major terpenes from ObOE on Hb accumulation could have positive fallouts on ?-thalassemia and sickle cells anemia.
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    ..Until now the nuclear protein NeuN was considered to be the panneuronal differentiation marker and was used in the studies of neurogenesis.
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    ..By induced RNAi we demonstrate that the conserved nuclear protein Bx42 is essential for the development of many tissues...
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    ..TBEV-NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1)...
  90. Porquier A, Morgant G, Moraga J, Dalmais B, Luyten I, Simon A, et al. The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)2Cys6 transcription factor BcBot6. Fungal Genet Biol. 2016;96:33-46 pubmed publisher
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    ..from a Challenge launched by National Cancer Institute, we identified TP53INP2 (tumor protein p53-inducible nuclear protein 2) at 20q11.22 to be significantly associated with ER-negative breast cancer (Z = -5.013, p = 5...
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    Relative to the commonly used mitochondrial and nuclear protein-coding genes, the noncoding intron sequences are a promising source of informative markers that have the potential to resolve difficult phylogenetic nodes such as rapid ..