Gene Symbol: RILPL1
Description: Rab interacting lysosomal protein like 1
Alias: GOSPEL, RLP1, RILP-like protein 1, GAPDH competitor of SIAH protein enhances life
Species: human
Products:     RILPL1

Top Publications

  1. Wang T, Wong K, Hong W. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. Mol Biol Cell. 2004;15:815-26 pubmed
    ..Two novel proteins related to RILP were identified and are tentatively referred to as RLP1 and RLP2 (for RILP-like protein 1 and 2, respectively)...
  2. Sen N, Hara M, Ahmad A, Cascio M, Kamiya A, Ehmsen J, et al. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009;63:81-91 pubmed publisher
    ..We report a 52 kDa cytosolic protein, GOSPEL, which physiologically binds GAPDH, in competition with Siah, retaining GAPDH in the cytosol and preventing its ..
  3. Schaub J, Stearns T. The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content. Mol Biol Cell. 2013;24:453-64 pubmed publisher
    ..We report that Rab effector-related proteins Rab-interacting lysosomal protein-like 1 (Rilpl1) and Rilpl2 regulate protein localization in the primary cilium...
  4. Steger M, Diez F, Dhekne H, Lis P, Nirujogi R, Karayel Ö, et al. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. elife. 2017;6: pubmed publisher
    ..Affinity enrichment mass spectrometry revealed that the primary ciliogenesis regulator, RILPL1 specifically interacts with the LRRK2-phosphorylated forms of Rab8A and Rab10, whereas RILPL2 binds to ..
  5. González M, Romero J, Ingaramo M, Muñoz Sosa C, Curtino J, Carrizo M. Enhancement by GOSPEL protein of GAPDH aggregation induced by nitric oxide donor and its inhibition by NAD(.). FEBS Lett. 2016;590:2210-20 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase's (GAPDH's) competitor of Siah Protein Enhances Life (GOSPEL) is the protein that competes with Siah1 for binding to GAPDH under NO-induced stress conditions preventing Siah1-bound GAPDH nuclear ..