Genomes and Genes
Gene Symbol: rhodopsin
Alias: CSNBAD1, OPN2, RP4, opsin 2, rod pigment, opsin-2
Publications213 found, 100 shown here
- Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapyHugo F Mendes
Division of Pathology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
Trends Mol Med 11:177-85. 2005..Mutations in rhodopsin are the most common cause of autosomal-dominant RP (ADRP)...
- Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutationsS G Jacobson
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, FL 33101
Am J Ophthalmol 112:256-71. 1991..autosomal dominant retinitis pigmentosa, who represented five different point mutations in the gene encoding rhodopsin. In a family with a stop codon mutation at the carboxyl end of the molecule (glutamine-344), young members with ..
- A dual role for EDEM1 in the processing of rod opsinMaria Kosmaoglou
UCL Institute of Ophthalmology, London, UK
J Cell Sci 122:4465-72. 2009....
- A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosaC F Inglehearn
Department of Human Genetics, University of Newcastle upon Tyne, England
Am J Hum Genet 48:26-30. 1991..The gene encoding rhodopsin, the rod photoreceptor pigment, is closely linked to locus D3S47 on chromosome 3q...
- A point mutation of the rhodopsin gene in one form of retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
Nature 343:364-6. 1990..As the gene coding for rhodopsin is also assigned to the long arm of chromosome 3 and is expressed in rod photoreceptors that are affected early ..
- Mutational analysis of the rhodopsin gene in Chinese ADRP families by conformation sensitive gel electrophoresisXiao L Zhang
Center for Molecular Diagnosis and Gene Therapy, Affiliated South West Hospital, Third Military Medical University, Chongqing, PR China
Life Sci 78:1494-8. 2006..For autosomal dominant retinitis pigmentosa (ADRP), the most common gene is the rhodopsin (RHO) gene, mutations in which contribute to about 25% of ADRP in Caucasian population...
- Mutation spectrum and frequency of the RHO gene in 248 Chinese families with retinitis pigmentosaShiqiang Li
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
Biochem Biophys Res Commun 401:42-7. 2010Mutations in the rhodopsin gene (RHO) are suggested to be the most common cause of autosomal dominant retinitis pigmentosa (RP)...
- Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutationP A Sieving
Department of Ophthalmology, University of Michigan, Ann Arbor 48105
Proc Natl Acad Sci U S A 92:880-4. 1995A human rhodopsin mutation, Gly-90-->Asp (Gly90Asp), cosegregated with an unusual trait of congenital nightblindness in 22 at-risk members of a large autosomal dominant kindred...
- Mutation analysis of codons 345 and 347 of rhodopsin gene in Indian retinitis pigmentosa patientsM Dikshit
Division of Biochemistry, Department of Chemistry, University of Pune, Pune 411 007, India
J Genet 80:111-6. 2001More than 100 mutations have been reported till date in the rhodopsin gene in patients with retinitis pigmentosa...
- Retinitis pigmentosa: mutation analysis of RHO, PRPF31, RP1, and IMPDH1 genes in patients from IndiaMamatha Gandra
Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya Chennai, India
Mol Vis 14:1105-13. 2008To screen for possible disease-causing mutations in rhodopsin (RHO), pre-mRNA processing factor 31 (PRPF31), retinitis pigmentosa 1 (RP1), and inosine monophosphate dehydrogenase 1 (IMPDH1) genes in Indian patients with isolated and ..
- Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
N Engl J Med 323:1302-7. 1990Night blindness is an early symptom of retinitis pigmentosa. The rod photoreceptors are responsible for night vision and use rhodopsin as the photosensitive pigment.
- Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosaC Reig
Secció de Genética del Hospital Sant Joan de Déu, Barcelona, Spain
Hum Genet 94:283-6. 1994..Approximately 30% of ADRP patients show point mutations or small deletions in the rhodopsin gene. However, over 50% of the RP patients are simplex cases (sporadic)...
- Missense rhodopsin mutation in a family with recessive RPG Kumaramanickavel
Nat Genet 8:10-1. 1994
- A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindnessN al-Jandal
Wellcome Ocular Genetics Unit, Trinity College, Dublin, Ireland
Hum Mutat 13:75-81. 1999More than 100 mutations within the rhodopsin gene have been found to be responsible for some forms of retinitis pigmentosa, a progressive retinal degeneration characterized by night blindness and subsequent disturbance of day vision that ..
- Description of a new mutation in rhodopsin, Pro23Ala, and comparison with electroretinographic and clinical characteristics of the Pro23His mutationK T Oh
Department of Opthamology and Visual Science, University of Iowa Hospitals and Clinics, Iowa City, USA
Arch Ophthalmol 118:1269-76. 2000..autosomal dominant retinitis pigmentosa caused by a proline-to-alanine mutation at codon 23 (Pro23Ala) of the rhodopsin gene and to compare this phenotype with that associated with the more common proline-to-histidine mutation at ..
- Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresisV C Sheffield
Department of Pediatrics, University of Iowa, Iowa City
Am J Hum Genet 49:699-706. 1991..of RP has been the recognition that some cases of autosomal dominant RP (ADRP) are caused by mutations in the rhodopsin gene...
- A two-stage approach identifies a Q344X mutation in the rhodopsin gene of a Chinese Singaporean family with autosomal dominant retinitis pigmentosaR Y Y Yong
Centre for Biomedical Sciences, Defence Medical and Enviromental Research Institute, DSO National Laboratories, Singapore
Ann Acad Med Singapore 34:94-9. 2005..Using a two-stage approach by combining linkage analysis with mutation detection, we have rapidly identified the gene locus and the mutation site of a Chinese Singaporean family with autosomal dominant RP...
- A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemMichelle E Illing
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
J Biol Chem 277:34150-60. 2002..30-40% of human autosomal dominant (AD) RP is caused by dominantly inherited missense mutations in the rhodopsin gene...
- Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)K Fujiki
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Jpn J Hum Genet 37:125-32. 1992The mutations of codon 17, 23, 58, and 347 of rhodopsin gene were investigated in 24 unrelated Japanese families including 33 patients with autosomal dominant retinitis pigmentosa (ADRP)...
- Ocular findings associated with a rhodopsin gene codon 106 mutation. Glycine-to-arginine change in autosomal dominant retinitis pigmentosaG A Fishman
Department of Ophthalmology, University of Illinois, Chicago 60612
Arch Ophthalmol 110:646-53. 1992..family were found to have a guanine-to-adenine transition mutation in the first nucleotide of codon 106 in the rhodopsin gene that results in a glycine-to-arginine change...
- Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsinJ P Macke
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Am J Hum Genet 53:80-9. 1993Ten rhodopsin mutations have been found in a screen of 282 subjects with retinitis pigmentosa (RP), 76 subjects with Leber congenital amaurosis, and 3 subjects with congenital stationary night blindness...
- Isolation and nucleotide sequence of the gene encoding human rhodopsinJ Nathans
Proc Natl Acad Sci U S A 81:4851-5. 1984We have isolated and completely sequenced the gene encoding human rhodopsin. The coding region of the human rhodopsin gene is interrupted by four introns, which are located at positions analogous to those found in the previously ..
- Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindnessT P Dryja
Berman Gund Laboratory, Harvard Medical School, Boston, Massachusetts 02114
Nat Genet 4:280-3. 1993A number of mutations in the rhodopsin gene have been shown to cause both dominant and recessive retinitis pigmentosa. Here we describe another phenotype associated with a defect in this gene...
- Rhodopsin mutations in autosomal dominant retinitis pigmentosaC H Sung
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 88:6481-5. 1991..161 unrelated patients with autosomal dominant retinitis pigmentosa were screened for point mutations in the rhodopsin gene by using the polymerase chain reaction and denaturing gradient gel electrophoresis...
- Mutation screening and haplotype analysis of the rhodopsin gene locus in Japanese patients with retinitis pigmentosaYuichiro Ando
Department of Rehabilitation Engineering, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan
Mol Vis 13:1038-44. 2007To identify nucleotide sequence variations in the rhodopsin (RHO) gene of Japanese patients with retinitis pigmentosa (RP) in order to search for mutations or haplotypes responsible for RP.
- Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston
Proc Natl Acad Sci U S A 88:9370-4. 1991We searched for point mutations in every exon of the rhodopsin gene in 150 patients from separate families with autosomal dominant retinitis pigmentosa...
- A complete screen for mutations of the rhodopsin gene in a panel of Chinese patients with autosomal dominant retinitis pigmentosaXiao Li Zhang
Clinical Laboratory Center, Affiliated South West Hospital, Third Military Medical University, Chongqing 400038
Chin Med Sci J 20:30-4. 2005To evaluate the prevalence of rhodopsin (RHO) mutations and the genotype-phenotype relationships in Chinese patients with autosomal dominant retinitis pigmentosa (ADRP) by conformation sensitive gel electrophoresis (CSGE) and direct DNA ..
- Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approachM S Gorbatyuk
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
Mol Vis 11:648-56. 2005To develop a hammerhead ribozymes (Rz) that might be exploited in a "digest and replace" gene therapy strategy for autosomal dominant retinitis pigmentosa (ADRP) caused by mutations in the gene for rhodopsin (RHO).
- Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibitionR Dechend
, , Humboldt University of Berlin, Germany
Am J Hypertens 14:55S-61S. 2001..These data may in part explain cholesterol-independent, HMG-CoA reductase-related, protective effects...
- Vaginal topography does not correlate well with visceral position in women with pelvic organ prolapseK Kenton
Rush Medical College, Chicago, IL 60612-3873, USA
Int Urogynecol J Pelvic Floor Dysfunct 8:336-9. 1997..67 and rho = 0.55, respectively). It was concluded that vaginal topography does not reliably predict the position of the associated viscera on PFF in women with primary or recurrent pelvic organ prolapse...
- Cloning and analysis of YMR26, the nuclear gene for a mitochondrial ribosomal protein in Saccharomyces cerevisiaeW Kang
Graduate School of Science and Technology, Faculty of Science, Kobe University, Japan
Mol Gen Genet 225:474-82. 1991..However, in rho o cells, its transcription appeared not to be repressed even by high concentrations of glucose. The amount of the YMR26 mRNA was increased 10-fold when cells carried the YMR26 gene on a high-copy number plasmid...
- Caffeine consumption in hospitalized psychiatric patientsM Rihs
Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Lausanne, Switzerland
Eur Arch Psychiatry Clin Neurosci 246:83-92. 1996..Our data suggest that inquiry into caffeine consumption should be included routinely for psychiatric patients, e.g. at admission, because patients with a psychotic disorder undergo a higher risk for an excessive caffeine consumption...
- Cocaine elicits action potential bursts in a central snail neuron: the role of delayed rectifying K+ currentY H Chen
Department of Nursing, Yuan Pei University of Science and Technology, No 306, Yuan Pei Road, Hsinchu, Taiwan
Neuroscience 138:257-80. 2006The effects of cocaine were studied in an identifiable RP4 neuron of the African snail, Achatina fulica Ferussac, using the two-electrode voltage-clamp method...
- Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-contN Graudal
Department of Pulmonary Medicine P/Chest Clinic, Bispebjerg Hospital, Copenhagen, Denmark
Horm Metab Res 24:130-3. 1992..Plasma ANP increases during exercise. The calcium antagonist, isradipine, does not alter resting levels or exercise induced levels of plasma ANP...
- Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cellsE Ashihara
Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
J Cell Physiol 171:343-56. 1997..Therefore, activation of the expression of the Epo receptor gene and activation of the erythroid differentiation program are two independent events in normal hematopoiesis...
- Lovastatin reduces renal vascular reactivity in spontaneously hypertensive ratsJ Jiang
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Hypertens 11:1222-31. 1998....
- Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cellsT Kusama
Molecular Neurobiology, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224
Br J Pharmacol 109:200-6. 1993..Thus,the rho l receptor displayed higher cooperativity.8. Unlike typical GABAA receptors, the rho l receptor was insensitive to the competitive antagonists bicuculline, SR95531, securinine, and (+)-tubocurarine...
- Depressive disorder as possible risk factor of osteoporosisM Vrkljan
Division of Endocrinology, Diabetes and Metabolic Diseases, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Coll Antropol 25:485-92. 2001..01 level (2-tailed). Patients under long-term history of depression could develop a very stronger type of osteoporosis i.e. it is before known that the patients with untreated Cushing syndrome developed hard osteoporosis...
- The mcGill-Melzack Pain Questionnaire in the diagnosis of headacheR A Allen
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
Headache 22:20-9. 1982..05) suggesting that the MMPQ is of value in headache diagnosis. Differences between electromyographic studies and headache pain report are discussed as well as suggestions concerning modification of the MMPQ for headache assessment...
- Measurement of thoracic and lumbar fracture kyphosis: evaluation of intraobserver, interobserver, and technique variabilityT R Kuklo
Orthopaedic Surgery Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
Spine (Phila Pa 1976) 26:61-5; discussion 66. 2001....
- Differentiation between renovascular and essential hypertension by means of changes in single kidney 99mTc-DTPA clearance induced by angiotensin-converting enzyme inhibitionE B Pedersen
Department of Medicine C, Aarhus Kommunehospital, Denmark
Am J Hypertens 2:323-34. 1989....
- Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632P V Rao
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina7710, USA
Invest Ophthalmol Vis Sci 42:1029-37. 2001..Rho kinase, a critical downstream effector of Rho GTPase is recognized to control the formation of actin stress fibers, focal adhesions, and cellular contraction...
- [Effects of fasudil on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma.]Feng Qin Wu
Department of Respiratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
Zhonghua Jie He He Hu Xi Za Zhi 32:847-9. 2009..To explore the role of Rho kinase-1 (ROCK-1) in airway inflammation of asthma by observing the effects of fasudil, a specific inhibitor of ROCK-1, on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma...
- Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosisToshinori Ito
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Spine (Phila Pa 1976) 32:2070-5. 2007..Immunohistochemical and behavioral study using a rat cauda equina compression model...
- Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 functionJ M Crawford
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710 7599, USA
Dev Biol 204:151-64. 1998..These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning...
- Risk factors for asthma in adult twinsSimon Francis Thomsen
Department of Respiratory Medicine Bispebjerg University Hospital Copenhagen, Denmark
Clin Respir J 1:128-9. 2007..Finally, asthma and posSPT, and rhinitis and posSPT show similar environmental architectures. These results provide new insights into the aetiology of asthma and may be used to guide the choice of traits for genetic linkage analysis...
- Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxinJ T Barbieri
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee 53226, USA
Int J Med Microbiol 290:381-7. 2000..aeruginosa by macrophages. Other studies indicate that Ras plays a role in T cell activation (Cantrell, 1994). Thus, ExoS may inhibit acquired immunity by inhibiting T-cell activation...
- Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding proteinJ A Glaven
Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 271:27374-81. 1996..These findings raise the possibility that in addition to acting directly as a GEF for Rho, Lfc may play other roles that influence the signaling activities of Rac and/or coordinate the activities of the Rac and Rho proteins...
- Sleepiness in different situations measured by the Epworth Sleepiness ScaleM W Johns
Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
Sleep 17:703-10. 1994..The SP in one test situation, including the MSLT, may not be a reliable indicator of a subject's average SP in daily life. Perhaps we should reexamine the current concept of daytime sleepiness and its measurement...
- [Differences in glycemic balance (but not weight) correlate positively with changes in absolute cardiovascular risk in diabetic patients]S Hadjadj
, Centre Hospitalier Universitaire d'Angers
Arch Mal Coeur Vaiss 93:1033-6. 2000..008 and Rho = 0.019; NS, respectively). These results suggest that, in diabetic patients, changes in glycaemic control affect their CRP by an effect on total cholesterol, but the changes in body weight do not affect their CRP...
- Isolation and sequencing of the rho gene from Streptomyces lividans ZX7 and characterization of the RNA-dependent NTPase activity of the overexpressed proteinC J Ingham
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12, United Kingdom
J Biol Chem 271:21803-7. 1996....
- Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized ratAdeleke M Badejo
Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008....
- Ongoing ultradian activity rhythms in the common vole, Microtus arvalis, during deprivations of food, water and restM P Gerkema
Zoological Laboratory, Groningen University, The Netherlands
J Comp Physiol A 168:591-7. 1991..The onset of the subsequent rest episodes occurred independent of the duration of the preceding alpha'. The duration of rho' was dependent on the preceding, experimental alpha' in a periodic fashion.(ABSTRACT TRUNCATED AT 250 WORDS)..
- The insensitivity to uncouplers of testis mitochondrial ATPaseM E Vazquez-Memije
Sección de Regulación Metabólica, Unidad de Investigación Biomédica del Centro Médico Nacional, Mexico
Arch Biochem Biophys 260:67-74. 1988..Since testis ATPase is known to be loosely bound to the membrane, an effect of albumin, improving tightness in the interaction of the F1 and the F0 sectors of the ATPase, is suggested...
- Disc degeneration: a human cadaveric study correlating magnetic resonance imaging and quantitative discomanometryE P Southern
Memorial Orthopaedic Surgical Group, Long Beach, California, USA
Spine (Phila Pa 1976) 25:2171-5. 2000..Quantitative discomanometry may be an important technique for evaluating early disc degeneration, especially tears of the anular fibers, which may be missed on magnetic resonance imaging...
- Schwan equation and transmembrane potential induced by alternating electric fieldP Marszalek
Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
Biophys J 58:1053-8. 1990..The good fit of these data to the curves calculated using the Schwan Equation indicates that the equation may be used to describe the transmembrane potential of a living cell generated by an oscillating electric field...
- Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouseMatthew Campbell
Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Ireland
Exp Eye Res 85:714-20. 2007....
- The Rhodobacter sphaeroides 2.4.1 rho gene: expression and genetic analysis of structure and functionM Gomelsky
Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, Texas 77030, USA
J Bacteriol 178:1946-54. 1996..The gene downstream of rho is homologous to thdF, whose product is involved in thiophene and furan oxidation...
- An assessment of the reliability of the ScoliometerG A Murrell
Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina
Spine (Phila Pa 1976) 18:709-12. 1993..998 for the thoracic and lumbar regions, respectively). These results indicate that the Scoliometer can be a reliable noninvasive method for repetitively assessing spinal axial rotation when used by a single trained observer...
- Theoretical study of hydrogen bonding interaction in nitroxyl (HNO) dimer: interrelationship of the two N-H...O blue-shifting hydrogen bondsYing Liu
Key Laboratory of Environmental Optical and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, P R China
J Phys Chem A 110:11760-4. 2006..Ranging from 2.55 to 2.85 A, the cooperative ascending tendencies of the electron densities in two sigma*(N-H) with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H)...
- Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibitionDai Yamanouchi
Department of Vascular Surgery, Nagoya University Graduate School of Medical Sciences, Nagoya University, Japan
J Vasc Surg 42:757-64. 2005..We therefore examined the effects of a hydrophilic statin on vein graft intimal hyperplasia in vivo and Rho-kinase activity in vitro...
- The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathwayYasuharu Sasaki
Department of Pharmacology, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, 108 8641, Tokyo, Japan
Pharmacol Ther 93:225-32. 2002..In this review, we address the possible role of Rho-kinase in neuronal functions, using the Rho-kinase specific inhibitor H-1152P...
- Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapyHeba E Abdelmaksoud
Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Exp Eye Res 88:859-79. 2009..Lead hhRz 266 CUC [see in text downward arrow] proved more efficacious than Rz525/hhRz485 which infers viability for rescue of retinal degeneration in appropriate preclinical models of disease...
- Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constrictionHidemi Kajimoto
Vascular Biology Group, Alberta Cardiovascular and Stroke Research Centre ABACUS, University of Alberta, Edmonton, Canada
Circulation 115:1777-88. 2007..Subsequent membrane depolarization and calcium influx through L-type calcium channels initiates functional closure. We hypothesize that Rho-kinase activation is an additional mechanism that sustains DA constriction...
- Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosisKumi Kitamura
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Gastroenterol Hepatol 22:2022-33. 2007..In this study, the involvement of the Rho/Rho kinase pathway on angiotensin II signaling in liver fibrogenesis and generation of steatosis was investigated...
- Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signalingCarlos Torre
Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94121, USA
Arch Otolaryngol Head Neck Surg 136:493-501. 2010....
- [Abnormal erythrocyte sodium transport in patients with adult polycystic kidney and hypertension]C Guarena
Arch Mal Coeur Vaiss 86:1241-3. 1993....
- Observer variation in assessing spinal curvature and skeletal development in adolescent idiopathic scoliosisM S Goldberg
Department of Epidemiology and Biostatistics, McGill University, , Canada
Spine (Phila Pa 1976) 13:1371-7. 1988..Differences in agreement between surgeons and technicians were relatively minor. These results indicate that personnel trained at this clinic are able to assess these spinal parameters reliably...
- Expression of Rho GTPases Rho-A and Rac1 in the adult and developing gerbil cerebellumVaea Richard
INSERM U 929, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000 Clermont Ferrand, France
Int J Dev Neurosci 26:723-32. 2008..In addition Rho-A is highly expressed in granule cell progenitor cells present in the external granular layer and therefore may play an important role in granule cell progenitor migration...
- DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNAJ A Stuart
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Nucleic Acids Res 32:2181-92. 2004....
- Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivoKenichi Tokuyama
Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan
Pharmacology 64:189-95. 2002..These results suggest that Y-27632 is not a useful agent in attenuating airway microvascular leakage which is seen in asthma, although it is potent in inhibiting airflow obstruction...
- Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeletonD R Haudenschild
Division of Arthritis Research MEM161, The Scripps Research Institute, La Jolla, CA, USA
Biorheology 45:219-28. 2008..Furthermore, we show that Rho kinase activity is required for this actin reorganization and gene expression induced by dynamic compression...
- Complete physicochemical characterization of DNA/chitosan complexes by multiple detection using asymmetrical flow field-flow fractionationPei Lian Ma
Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3A7
Anal Chem 82:9636-43. 2010..This study demonstrates the ability of AF4/UV-vis/MALS+DLS to provide a complete physicochemical characterization of DNA/polycation complexes used in nonviral gene delivery...
- Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?James Bellingham
Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, United Kingdom
J Exp Zool B Mol Dev Evol 297:1-10. 2003..of rho (which is expressed uniquely in the retina) and the closely related extraretinal rod-like opsin (exo-rhodopsin) gene, errlo (which is expressed uniquely in the pineal), in the puffer-fish, Fugu rubripes (Takifugu rubripes)...
- The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathwayH Teramoto
Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
J Biol Chem 271:25731-4. 1996....
- Rho kinase-mediated vasoconstriction in pulmonary hypertensionIvan F McMurtry
Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA
Adv Exp Med Biol 661:299-308. 2010..We suspect the same will be true in at least some forms of human pulmonary arterial hypertension...
- Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathyKeisuke Mori
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
Invest Ophthalmol Vis Sci 43:2001-6. 2002..Traction retinal detachment is a central feature of both types of disease. Hemizygous rhodopsin promoter/PDGF-B (rho/PDGF-B) transgenic mice exhibit proliferation of vascular cells, glia, and retinal ..
- Dietary protein restriction stress in the domestic turkey (Meleagris gallopavo) induces hypofunction and remodeling of adrenal steroidogenic tissueR V Carsia
Department of Cell Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford 08084, USA
Gen Comp Endocrinol 109:140-53. 1998..In addition, the present study suggests that this nutritional stressor induces marked remodeling of the steroidogenic tissue in the turkey adrenal gland...
- Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitorsStephanie J Turner
Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, CA 92093 0652, USA
Biochem Pharmacol 75:405-13. 2008..In conclusion, we quantified effects of lovastatin on RhoA, B, and C isoforms, and provide a molecular mechanism whereby statins cause accumulation of unprenylated Rho-GTP...
- Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganizationL M Machesky
Department of Molecular Medicine, Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
J Cell Biol 138:913-26. 1997..It appears, therefore, that the assembly of large integrin complexes is not required for most of the actin reorganization or cell morphology changes induced by Rac or Rho activation in Swiss 3T3 fibroblasts...
- Regulation of rho-dependent transcription termination by NusG is specific to the Escherichia coli elongation complexZ Pasman
Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, Oregon 97403, USA
Biochemistry 39:5573-85. 2000..Thus, we conclude that NusG modulates Rho-dependent termination by interacting specifically with the RNAP of the E. coli elongation complex to render the complex more susceptible to the termination activity of Rho...
- Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseHiroki Chikumi
Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
J Biol Chem 277:12463-73. 2002....
- Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflowPonugoti Vasantha Rao
Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
Mol Vis 11:288-97. 2005..This study employed a molecular approach to specifically address the role of Rho-kinase in the modulation of aqueous humor outflow...
- Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudilZen Kong Dai
Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Pediatr Pulmonol 46:45-59. 2011..Further translational study in human is needed to substantiate the findings...
- Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasionYuji Nakata
Department of Pathology, Keio University School of Medicine, Tokyo, Japan
Exp Hematol 36:37-50. 2008....
- The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteriesJ Eduardo da Silva-Santos
Department of Physiology, Medical College of Georgia, Augusta, GA, USA
Crit Care Med 37:1716-23. 2009..We investigated whether a reduced activity in the Rho-A/Rho-kinase pathway could be involved in the impaired vascular reactivity observed in septic shock...
- Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiaeO Zelenaya-Troitskaya
Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
Genetics 148:1763-76. 1998..These findings are discussed in the context of a model relating mtDNA copy number control and stability to mtDNA recombination...
- A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoS Fukuhara
Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
J Biol Chem 274:5868-79. 1999....
- Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in ratsFu Hai Li
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan 250012, China
Chin Med J (Engl) 120:22-9. 2007..This study tested whether RhoA/Rho kinase pathway is involved in the pathogenesis of high flow induced pulmonary hypertension in rats...
- Bone oedema predicts erosive progression on wrist MRI in early RA--a 2-yr observational MRI and NC scintigraphy studyKari Palosaari
Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 50, FIN 90029, Box 50, Oulu, Finland
Rheumatology (Oxford) 45:1542-8. 2006..To investigate if disease assessment by contrast-enhanced dynamic and static magnetic resonance imaging (MRI) and quantitative nanocolloid (NC) scintigraphy gives useful additional information in early rheumatoid arthritis (RA)...
- A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cellsLei Wang
Division of Experimental Hematology and Molecular Developmental Biology Program, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Biol Chem 278:44617-25. 2003....
- The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cellsWilliam B Slayton
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
Blood 100:3975-82. 2002..This study supports a major role for the spleen in thrombopoiesis following engraftment of transplanted stem cells in irradiated mice...
- Characterisation of the enzymatic and RNA-binding properties of the Rhodobacter sphaeroides 2.4.1. Rho homologueC J Ingham
School of Biological Sciences, University Park, Nottingham University, Nottingham, NG7 2RD, UK
Biochim Biophys Acta 1446:115-25. 1999..The main differences between Rho factors from different bacteria is in the specificity of RNA binding although this does not appear to be necessarily dependent on the GC bias of target RNA as has been previously suggested...
- A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenasesOhgew Kweon
Microbiology Division, National Center for Toxicological Research US FDA, Jefferson, AR 72079, USA
BMC Biochem 9:11. 2008..Here, we present a scheme for classification of RHOs reflecting new sequence information and interactions between RHO enzyme components...
- Direct activation of phospholipase C-epsilon by RhoMichele R Wing
Department of Pharmacology, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:41253-8. 2003....
- Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patientsAndrew L Masica
Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
Am J Geriatr Pharmacother 5:218-31. 2007..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days...
- Simulation study of methods to detect periodontal associations when they are inconsistent among subjectsM E Cohen
Naval Dental Research Institute, Great Lakes, Illinois 60088-5259
Community Dent Oral Epidemiol 21:19-23. 1993....
- Noninvasive detection of an increased vascular mass in untreated hypertensive patientsX Girerd
Department of Internal Medicine, Broussais Hospital, Paris, France
Am J Hypertens 7:1076-84. 1994..Circumferential wall stress, calculated from diastolic internal diameter, wall thickness, and diastolic blood pressure, was not different in the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Mutations in an RNP1 consensus sequence of Rho protein reduce RNA binding affinity but facilitate helicase turnoverC A Brennan
Department of Biochemistry, University of Rochester, New York 14642
J Biol Chem 266:17296-305. 1991..Our results indicate that several different components of RNA interaction are required for rho activity and support a role for the RNP1 consensus region of rho in at least one specific aspect of RNA binding...
- Continuous monitoring of change in hemodilution during water immersion in humans: effect of water temperatureF Yamazaki
Department of Clinical Pathophysiology, School of Health Sciences, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Aviat Space Environ Med 71:632-9. 2000..The present study was designed to examine whether water temperature during head-out immersion (HOI) modifies hemodilution dynamics...
- Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in ratsFuhai Li
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan, China
Pharmacol Res 55:64-71. 2007..These results indicated that RhoA/Rho-kinase mediated pathway participated in the process of high flow induced pulmonary artery remodeling; inhibition of Rho kinase with fasudil could attenuate pulmonary artery remodeling...
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip B Wedegaertner; Fiscal Year: 2010..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip Wedegaertner; Fiscal Year: 2007..abstract_text> ..
- A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis PigmentosaJohn M Sullivan; Fiscal Year: 2010..Expected results are knowledge of the minimum amount of WT human rhodopsin that is needed to keep a mammalian rod photoreceptor alive and vital. Aim 3...
- Regulation of Rho Signaling by S-NitrosothiolsA Richard Whorton; Fiscal Year: 2010..Results from our studies will provide insight into prevention and development of potential therapeutic strategies. ..
- In the Penis, RhoA Activation is Enhanced by Guanine Nucleotide Exchange FactorsR Webb; Fiscal Year: 2009..Our research has identified novel cellular events regulating constrictor responses, and an understanding of how these events can be inhibited will provide an alternative therapeutic approach to treating erectile dysfunction. ..
- In the Penis, RhoA Activation is Enhanced by Guanine Nucleotide Exchange FactorsR Clinton Webb; Fiscal Year: 2010..Our research has identified novel cellular events regulating constrictor responses, and an understanding of how these events can be inhibited will provide an alternative therapeutic approach to treating erectile dysfunction. ..
- SIGNAL TRANSDUCTION PATHWAY MEDIATING CDK5 FUNCTIONLi Huei Tsai; Fiscal Year: 2000..Rachel Neve. The second specific aim proposes to carry out studies similar to those described above, but using transfection of each of the three proteins the applicant has found to interact with cdk5 in the two hybrid screen assay. ..
- Myosin Phosphatase Regulation in Vascular Smooth MuscleHOWARD SURKS; Fiscal Year: 2007..Elucidating the molecular pathways that regulate blood vessel tone is of utmost importance for understanding both normal vascular function and the major vascular diseases in our society. ..
- Excitation contraction coupling in bladder smooth muscleRobert S Moreland; Fiscal Year: 2010..The studies proposed in this application will provide this missing information. If we can learn how normal bladder is controlled, we can then design experiments to study and hopefully repair abnormal bladder ..
- Nitric Oxide Inhibits RhoA/Rho-kinase in Penile ErectionR Clinton Webb; Fiscal Year: 2006..These studies will define the molecular basis for NO-mediated cavernosal vasodilation in the normal state and how long-term changes in the Ca 2+ sensitizing mechanism contribute to erectile dysfunction. ..
- Mechanisms Driving Cortical Cytoskeleton Dynamics in Cancer Cell InvasionKathryn M Eisenmann; Fiscal Year: 2010..We anticipate that our experiments will shed light on basic and conserved mechanisms of cytoskeletal remodeling during various behaviors in diverse cell types. ..
- ROCK II-mediated regulation of centrosome duplication / centrosome amplificationKenji Fukasawa; Fiscal Year: 2010....
- Sphingolipid Signaling in Endothelial Responses to InjuryTERESA SANCHEZ GARCIA VAO; Fiscal Year: 2010..Answering these questions will help us to design new drugs that inhibit or activate S1P2R, which could be used as new therapies to alleviate the symptoms of atherosclerosis, diabetes or sepsis. ..
- Rho-Dependent COX-2 Expression in Intestinal CellsLee Slice; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
- Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor OutflowP Vasantha Rao; Fiscal Year: 2010....
- Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor OutflowP Rao; Fiscal Year: 2009....
- Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor OutflowP Rao; Fiscal Year: 2009....
- Role of Rho Kinase in Aqueous Humor Outflow PathwayP Rao; Fiscal Year: 2004..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
- Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouseRichard E Mains; Fiscal Year: 2010..We plan to use the Kalirin-7 knockout mouse that we generated to elucidate the pathway(s) controlling spine formation and structure. ..
- Mechanism and role of DLC-1 tumor suppressor loss in lung cancerChanning J Der; Fiscal Year: 2010..Hence, we believe that our elucidation of the mechanism by which DLC-1 loss may deregulate Rho GTPases and promote NSCLC growth may define novel directions for targeted therapies for lung cancer treatment. ..
- Role of Surface Roughness in Regulating Tumor Cell BehaviorSarah Glover; Fiscal Year: 2009....
- Role of Surface Roughness in Regulating Tumor Cell BehaviorSarah C Glover; Fiscal Year: 2010....
- G Proteins and Endothelial Barrier RegulationTatyana Voyno Yasenetskaya; Fiscal Year: 2004..abstract_text> ..
- Statins and VEGF-induced cytoskeletal remodelingFARHAD DANESH; Fiscal Year: 2009..abstract_text> ..
- BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASEBEATRICE YUE; Fiscal Year: 2009..The overall goal of our proposal is to illustrate the mechanisms to provide a deeper understanding regarding the pathogenesis of glaucomas. ..
- STRUCTURE/FUNCTION OF FOCAL ADHESIONSKeith Burridge; Fiscal Year: 2000..The effect of vinculin on PIP2 hydrolysis will be studied. We will determine which domain of vinculin restores anchorage-dependent growth when transfected into cells with reduced vinculin expression. ..
- Rho- and GPCR-mediated signaling through novel cellular effectorsJoan Heller Brown; Fiscal Year: 2010....