rhodopsin

Summary

Gene Symbol: rhodopsin
Description: rhodopsin
Alias: CSNBAD1, OPN2, RP4, opsin 2, rod pigment, opsin-2
Species: human

Top Publications

  1. ncbi Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy
    Hugo F Mendes
    Division of Pathology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Trends Mol Med 11:177-85. 2005
  2. pmc A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa
    C F Inglehearn
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Am J Hum Genet 48:26-30. 1991
  3. pmc IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA
    Sarah E Mortimer
    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Biol Chem 283:36354-60. 2008
  4. ncbi Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment site
    T J Keen
    Molecular Genetics Unit, Department of Human Genetics, Newcastle upon Tyne, United Kingdom
    Genomics 11:199-205. 1991
  5. pmc A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa
    Maleeha Azam
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 15:2526-34. 2009
  6. ncbi Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa
    C Reig
    Secció de Genética del Hospital Sant Joan de Déu, Barcelona, Spain
    Hum Genet 94:283-6. 1994
  7. doi Novel PRPF31 and PRPH2 mutations and co-occurrence of PRPF31 and RHO mutations in Chinese patients with retinitis pigmentosa
    King Poo Lim
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Arch Ophthalmol 127:784-90. 2009
  8. pmc Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patients
    Isabelle Audo
    INSERM, U968, Paris, France
    Invest Ophthalmol Vis Sci 51:3687-700. 2010
  9. ncbi A point mutation of the rhodopsin gene in one form of retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    Nature 343:364-6. 1990
  10. pmc Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190N
    Irena Tsui
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Curr Eye Res 33:1014-22. 2008

Detail Information

Publications222 found, 100 shown here

  1. ncbi Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy
    Hugo F Mendes
    Division of Pathology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Trends Mol Med 11:177-85. 2005
    ..Mutations in rhodopsin are the most common cause of autosomal-dominant RP (ADRP)...
  2. pmc A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa
    C F Inglehearn
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Am J Hum Genet 48:26-30. 1991
    ..The gene encoding rhodopsin, the rod photoreceptor pigment, is closely linked to locus D3S47 on chromosome 3q...
  3. pmc IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA
    Sarah E Mortimer
    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Biol Chem 283:36354-60. 2008
    ..Finally, we find that IMPDH1 is associated with polyribosomes containing rhodopsin mRNA...
  4. ncbi Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment site
    T J Keen
    Molecular Genetics Unit, Department of Human Genetics, Newcastle upon Tyne, United Kingdom
    Genomics 11:199-205. 1991
    Several mutations in the rhodopsin gene in patients affected by autosomal dominant retinitis pigmentosa (ADRP) have recently been described...
  5. pmc A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa
    Maleeha Azam
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 15:2526-34. 2009
    ..To identify the gene mutations responsible for autosomal recessive retinitis pigmentosa (arRP) in Pakistani families...
  6. ncbi Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa
    C Reig
    Secció de Genética del Hospital Sant Joan de Déu, Barcelona, Spain
    Hum Genet 94:283-6. 1994
    ..Approximately 30% of ADRP patients show point mutations or small deletions in the rhodopsin gene. However, over 50% of the RP patients are simplex cases (sporadic)...
  7. doi Novel PRPF31 and PRPH2 mutations and co-occurrence of PRPF31 and RHO mutations in Chinese patients with retinitis pigmentosa
    King Poo Lim
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Arch Ophthalmol 127:784-90. 2009
    ..To screen mutations in the PRPF31, RHO, and PRPH2 genes in Chinese patients with retinitis pigmentosa (RP)...
  8. pmc Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patients
    Isabelle Audo
    INSERM, U968, Paris, France
    Invest Ophthalmol Vis Sci 51:3687-700. 2010
    PURPOSE. To identify the prevalence of rhodopsin (RHO) mutations in French patients with autosomal dominant rod-cone dystrophies (adRPs). Methods...
  9. ncbi A point mutation of the rhodopsin gene in one form of retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    Nature 343:364-6. 1990
    ..As the gene coding for rhodopsin is also assigned to the long arm of chromosome 3 and is expressed in rod photoreceptors that are affected early ..
  10. pmc Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190N
    Irena Tsui
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Curr Eye Res 33:1014-22. 2008
    ..To phenotype a family with RHO (Asp190Asn or D190N) dominantly inherited retinitis pigmentosa (RP) and to describe an approach to surveying affected families...
  11. ncbi Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family
    G J Farrar
    Department of Genetics, Trinity College Dublin, Ireland
    Hum Mol Genet 1:769-71. 1992
  12. pmc Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosa
    Kwang Joong Kim
    Center for Genome Science, National Institute of Health, Chungcheongbuk Do, Korea
    Mol Vis 17:844-53. 2011
    To determine the spectrum and frequency of rhodopsin gene (RHO) mutations in Korean patients with retinitis pigmentosa (RP) and to characterize genotype-phenotype correlations in patients with mutations.
  13. doi Linkage analysis and mutation screening of the rhodopsin gene in a Chinese Bai family with autosomal dominant retinitis pigmentosa
    Haike Guo
    Department of Ophthalmology, Guangdong Eye Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong, PR China
    J Hum Genet 55:571-6. 2010
    Autosomal dominant retinitis pigmentosa (adRP) is a common form of RP worldwide. Although rhodopsin (RHO) is the most frequently reported adRP gene in many populations, it has not been detected in patients from the Bai nationality, one ..
  14. doi Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB
    Christina Zeitz
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 49:4105-14. 2008
    ..The study was conducted to identify the genetic defect in a large Swiss family affected with adCSNB and to investigate the pathogenic mechanism of the mutation...
  15. pmc Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation
    P A Sieving
    Department of Ophthalmology, University of Michigan, Ann Arbor 48105
    Proc Natl Acad Sci U S A 92:880-4. 1995
    A human rhodopsin mutation, Gly-90-->Asp (Gly90Asp), cosegregated with an unusual trait of congenital nightblindness in 22 at-risk members of a large autosomal dominant kindred...
  16. ncbi The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation
    J Paul Chapple
    Division of Pathology, Institute of Ophthalmology, University College of London, London EC1V 9EL, United Kingdom
    J Biol Chem 278:19087-94. 2003
    ..Because of their enrichment at the site of rhodopsin production, we investigated the effect of HSJ1 isoforms on the cellular processing of wild-type and mutant ..
  17. pmc Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin
    J P Macke
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Am J Hum Genet 53:80-9. 1993
    Ten rhodopsin mutations have been found in a screen of 282 subjects with retinitis pigmentosa (RP), 76 subjects with Leber congenital amaurosis, and 3 subjects with congenital stationary night blindness...
  18. pmc Mutation screening and haplotype analysis of the rhodopsin gene locus in Japanese patients with retinitis pigmentosa
    Yuichiro Ando
    Department of Rehabilitation Engineering, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan
    Mol Vis 13:1038-44. 2007
    To identify nucleotide sequence variations in the rhodopsin (RHO) gene of Japanese patients with retinitis pigmentosa (RP) in order to search for mutations or haplotypes responsible for RP.
  19. ncbi Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain
    C H Sung
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 268:26645-9. 1993
    Over 40 mutations in the rhodopsin gene have been identified in patients with autosomal dominant retinitis pigmentosa...
  20. ncbi Mutational analysis of the rhodopsin gene in Chinese ADRP families by conformation sensitive gel electrophoresis
    Xiao L Zhang
    Center for Molecular Diagnosis and Gene Therapy, Affiliated South West Hospital, Third Military Medical University, Chongqing, PR China
    Life Sci 78:1494-8. 2006
    ..For autosomal dominant retinitis pigmentosa (ADRP), the most common gene is the rhodopsin (RHO) gene, mutations in which contribute to about 25% of ADRP in Caucasian population...
  21. ncbi Rhodopsin mutations in autosomal dominant retinitis pigmentosa
    M Al-Maghtheh
    Department of Molecular Genetics, University of London, England
    Hum Mutat 2:249-55. 1993
    ..cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade...
  22. pmc Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston
    Proc Natl Acad Sci U S A 88:9370-4. 1991
    We searched for point mutations in every exon of the rhodopsin gene in 150 patients from separate families with autosomal dominant retinitis pigmentosa...
  23. pmc A dual role for EDEM1 in the processing of rod opsin
    Maria Kosmaoglou
    UCL Institute of Ophthalmology, London, UK
    J Cell Sci 122:4465-72. 2009
    ....
  24. pmc Rhodopsin mutations in autosomal dominant retinitis pigmentosa
    C H Sung
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 88:6481-5. 1991
    ..161 unrelated patients with autosomal dominant retinitis pigmentosa were screened for point mutations in the rhodopsin gene by using the polymerase chain reaction and denaturing gradient gel electrophoresis...
  25. ncbi Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness
    T P Dryja
    Berman Gund Laboratory, Harvard Medical School, Boston, Massachusetts 02114
    Nat Genet 4:280-3. 1993
    A number of mutations in the rhodopsin gene have been shown to cause both dominant and recessive retinitis pigmentosa. Here we describe another phenotype associated with a defect in this gene...
  26. doi Mutation spectrum and frequency of the RHO gene in 248 Chinese families with retinitis pigmentosa
    Shiqiang Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Biochem Biophys Res Commun 401:42-7. 2010
    Mutations in the rhodopsin gene (RHO) are suggested to be the most common cause of autosomal dominant retinitis pigmentosa (RP)...
  27. ncbi Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations
    S G Jacobson
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, FL 33101
    Am J Ophthalmol 112:256-71. 1991
    ..autosomal dominant retinitis pigmentosa, who represented five different point mutations in the gene encoding rhodopsin. In a family with a stop codon mutation at the carboxyl end of the molecule (glutamine-344), young members with ..
  28. ncbi A two-stage approach identifies a Q344X mutation in the rhodopsin gene of a Chinese Singaporean family with autosomal dominant retinitis pigmentosa
    R Y Y Yong
    Centre for Biomedical Sciences, Defence Medical and Enviromental Research Institute, DSO National Laboratories, Singapore
    Ann Acad Med Singapore 34:94-9. 2005
    ..Using a two-stage approach by combining linkage analysis with mutation detection, we have rapidly identified the gene locus and the mutation site of a Chinese Singaporean family with autosomal dominant RP...
  29. ncbi Missense rhodopsin mutation in a family with recessive RP
    G Kumaramanickavel
    Nat Genet 8:10-1. 1994
  30. ncbi Ocular findings associated with a rhodopsin gene codon 106 mutation. Glycine-to-arginine change in autosomal dominant retinitis pigmentosa
    G A Fishman
    Department of Ophthalmology, University of Illinois, Chicago 60612
    Arch Ophthalmol 110:646-53. 1992
    ..family were found to have a guanine-to-adenine transition mutation in the first nucleotide of codon 106 in the rhodopsin gene that results in a glycine-to-arginine change...
  31. pmc Retinitis pigmentosa: mutation analysis of RHO, PRPF31, RP1, and IMPDH1 genes in patients from India
    Mamatha Gandra
    Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya Chennai, India
    Mol Vis 14:1105-13. 2008
    To screen for possible disease-causing mutations in rhodopsin (RHO), pre-mRNA processing factor 31 (PRPF31), retinitis pigmentosa 1 (RP1), and inosine monophosphate dehydrogenase 1 (IMPDH1) genes in Indian patients with isolated and ..
  32. ncbi A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system
    Michelle E Illing
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Biol Chem 277:34150-60. 2002
    ..30-40% of human autosomal dominant (AD) RP is caused by dominantly inherited missense mutations in the rhodopsin gene...
  33. pmc Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis
    V C Sheffield
    Department of Pediatrics, University of Iowa, Iowa City
    Am J Hum Genet 49:699-706. 1991
    ..of RP has been the recognition that some cases of autosomal dominant RP (ADRP) are caused by mutations in the rhodopsin gene...
  34. ncbi Description of a new mutation in rhodopsin, Pro23Ala, and comparison with electroretinographic and clinical characteristics of the Pro23His mutation
    K T Oh
    Department of Opthamology and Visual Science, University of Iowa Hospitals and Clinics, Iowa City, USA
    Arch Ophthalmol 118:1269-76. 2000
    ..autosomal dominant retinitis pigmentosa caused by a proline-to-alanine mutation at codon 23 (Pro23Ala) of the rhodopsin gene and to compare this phenotype with that associated with the more common proline-to-histidine mutation at ..
  35. ncbi Mutation analysis of codons 345 and 347 of rhodopsin gene in Indian retinitis pigmentosa patients
    M Dikshit
    Division of Biochemistry, Department of Chemistry, University of Pune, Pune 411 007, India
    J Genet 80:111-6. 2001
    More than 100 mutations have been reported till date in the rhodopsin gene in patients with retinitis pigmentosa...
  36. ncbi A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness
    N al-Jandal
    Wellcome Ocular Genetics Unit, Trinity College, Dublin, Ireland
    Hum Mutat 13:75-81. 1999
    More than 100 mutations within the rhodopsin gene have been found to be responsible for some forms of retinitis pigmentosa, a progressive retinal degeneration characterized by night blindness and subsequent disturbance of day vision that ..
  37. ncbi Different amino acid substitutions at the same position in rhodopsin lead to distinct phenotypes
    John Neidhardt
    University of Zurich, Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, Schwerzenbach, Switzerland
    Invest Ophthalmol Vis Sci 47:1630-5. 2006
    Identification of a novel rhodopsin mutation in a family with retinitis pigmentosa and comparison of the clinical phenotype to a known mutation at the same amino acid position.
  38. ncbi Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    N Engl J Med 323:1302-7. 1990
    Night blindness is an early symptom of retinitis pigmentosa. The rod photoreceptors are responsible for night vision and use rhodopsin as the photosensitive pigment.
  39. ncbi Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)
    K Fujiki
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Jpn J Hum Genet 37:125-32. 1992
    The mutations of codon 17, 23, 58, and 347 of rhodopsin gene were investigated in 24 unrelated Japanese families including 33 patients with autosomal dominant retinitis pigmentosa (ADRP)...
  40. pmc Isolation and nucleotide sequence of the gene encoding human rhodopsin
    J Nathans
    Proc Natl Acad Sci U S A 81:4851-5. 1984
    We have isolated and completely sequenced the gene encoding human rhodopsin. The coding region of the human rhodopsin gene is interrupted by four introns, which are located at positions analogous to those found in the previously ..
  41. ncbi A complete screen for mutations of the rhodopsin gene in a panel of Chinese patients with autosomal dominant retinitis pigmentosa
    Xiao Li Zhang
    Clinical Laboratory Center, Affiliated South West Hospital, Third Military Medical University, Chongqing 400038
    Chin Med Sci J 20:30-4. 2005
    To evaluate the prevalence of rhodopsin (RHO) mutations and the genotype-phenotype relationships in Chinese patients with autosomal dominant retinitis pigmentosa (ADRP) by conformation sensitive gel electrophoresis (CSGE) and direct DNA ..
  42. ncbi Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach
    M S Gorbatyuk
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
    Mol Vis 11:648-56. 2005
    To develop a hammerhead ribozymes (Rz) that might be exploited in a "digest and replace" gene therapy strategy for autosomal dominant retinitis pigmentosa (ADRP) caused by mutations in the gene for rhodopsin (RHO).
  43. ncbi Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition
    R Dechend
    , , Humboldt University of Berlin, Germany
    Am J Hypertens 14:55S-61S. 2001
    ..These data may in part explain cholesterol-independent, HMG-CoA reductase-related, protective effects...
  44. ncbi Vaginal topography does not correlate well with visceral position in women with pelvic organ prolapse
    K Kenton
    Rush Medical College, Chicago, IL 60612-3873, USA
    Int Urogynecol J Pelvic Floor Dysfunct 8:336-9. 1997
    ..67 and rho = 0.55, respectively). It was concluded that vaginal topography does not reliably predict the position of the associated viscera on PFF in women with primary or recurrent pelvic organ prolapse...
  45. ncbi Cloning and analysis of YMR26, the nuclear gene for a mitochondrial ribosomal protein in Saccharomyces cerevisiae
    W Kang
    Graduate School of Science and Technology, Faculty of Science, Kobe University, Japan
    Mol Gen Genet 225:474-82. 1991
    ..However, in rho o cells, its transcription appeared not to be repressed even by high concentrations of glucose. The amount of the YMR26 mRNA was increased 10-fold when cells carried the YMR26 gene on a high-copy number plasmid...
  46. ncbi Caffeine consumption in hospitalized psychiatric patients
    M Rihs
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Lausanne, Switzerland
    Eur Arch Psychiatry Clin Neurosci 246:83-92. 1996
    ..Our data suggest that inquiry into caffeine consumption should be included routinely for psychiatric patients, e.g. at admission, because patients with a psychotic disorder undergo a higher risk for an excessive caffeine consumption...
  47. ncbi Cocaine elicits action potential bursts in a central snail neuron: the role of delayed rectifying K+ current
    Y H Chen
    Department of Nursing, Yuan Pei University of Science and Technology, No 306, Yuan Pei Road, Hsinchu, Taiwan
    Neuroscience 138:257-80. 2006
    The effects of cocaine were studied in an identifiable RP4 neuron of the African snail, Achatina fulica Ferussac, using the two-electrode voltage-clamp method...
  48. ncbi Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-cont
    N Graudal
    Department of Pulmonary Medicine P/Chest Clinic, Bispebjerg Hospital, Copenhagen, Denmark
    Horm Metab Res 24:130-3. 1992
    ..Plasma ANP increases during exercise. The calcium antagonist, isradipine, does not alter resting levels or exercise induced levels of plasma ANP...
  49. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..Therefore, activation of the expression of the Epo receptor gene and activation of the erythroid differentiation program are two independent events in normal hematopoiesis...
  50. ncbi Lovastatin reduces renal vascular reactivity in spontaneously hypertensive rats
    J Jiang
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Hypertens 11:1222-31. 1998
    ....
  51. pmc Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells
    T Kusama
    Molecular Neurobiology, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224
    Br J Pharmacol 109:200-6. 1993
    ..Thus,the rho l receptor displayed higher cooperativity.8. Unlike typical GABAA receptors, the rho l receptor was insensitive to the competitive antagonists bicuculline, SR95531, securinine, and (+)-tubocurarine...
  52. ncbi The mcGill-Melzack Pain Questionnaire in the diagnosis of headache
    R A Allen
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Headache 22:20-9. 1982
    ..05) suggesting that the MMPQ is of value in headache diagnosis. Differences between electromyographic studies and headache pain report are discussed as well as suggestions concerning modification of the MMPQ for headache assessment...
  53. ncbi Depressive disorder as possible risk factor of osteoporosis
    M Vrkljan
    Division of Endocrinology, Diabetes and Metabolic Diseases, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Coll Antropol 25:485-92. 2001
    ..01 level (2-tailed). Patients under long-term history of depression could develop a very stronger type of osteoporosis i.e. it is before known that the patients with untreated Cushing syndrome developed hard osteoporosis...
  54. ncbi Measurement of thoracic and lumbar fracture kyphosis: evaluation of intraobserver, interobserver, and technique variability
    T R Kuklo
    Orthopaedic Surgery Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Spine (Phila Pa 1976) 26:61-5; discussion 66. 2001
    ....
  55. ncbi Differentiation between renovascular and essential hypertension by means of changes in single kidney 99mTc-DTPA clearance induced by angiotensin-converting enzyme inhibition
    E B Pedersen
    Department of Medicine C, Aarhus Kommunehospital, Denmark
    Am J Hypertens 2:323-34. 1989
    ....
  56. ncbi Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632
    P V Rao
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina7710, USA
    Invest Ophthalmol Vis Sci 42:1029-37. 2001
    ..Rho kinase, a critical downstream effector of Rho GTPase is recognized to control the formation of actin stress fibers, focal adhesions, and cellular contraction...
  57. ncbi Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis
    Toshinori Ito
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 32:2070-5. 2007
    ..Immunohistochemical and behavioral study using a rat cauda equina compression model...
  58. ncbi [Effects of fasudil on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma.]
    Feng Qin Wu
    Department of Respiratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:847-9. 2009
    ..To explore the role of Rho kinase-1 (ROCK-1) in airway inflammation of asthma by observing the effects of fasudil, a specific inhibitor of ROCK-1, on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma...
  59. ncbi Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function
    J M Crawford
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710 7599, USA
    Dev Biol 204:151-64. 1998
    ..These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning...
  60. ncbi Risk factors for asthma in adult twins
    Simon Francis Thomsen
    Department of Respiratory Medicine Bispebjerg University Hospital Copenhagen, Denmark
    Clin Respir J 1:128-9. 2007
    ..Finally, asthma and posSPT, and rhinitis and posSPT show similar environmental architectures. These results provide new insights into the aetiology of asthma and may be used to guide the choice of traits for genetic linkage analysis...
  61. ncbi Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin
    J T Barbieri
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee 53226, USA
    Int J Med Microbiol 290:381-7. 2000
    ..aeruginosa by macrophages. Other studies indicate that Ras plays a role in T cell activation (Cantrell, 1994). Thus, ExoS may inhibit acquired immunity by inhibiting T-cell activation...
  62. ncbi Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein
    J A Glaven
    Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:27374-81. 1996
    ..These findings raise the possibility that in addition to acting directly as a GEF for Rho, Lfc may play other roles that influence the signaling activities of Rac and/or coordinate the activities of the Rac and Rho proteins...
  63. ncbi Sleepiness in different situations measured by the Epworth Sleepiness Scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 17:703-10. 1994
    ..The SP in one test situation, including the MSLT, may not be a reliable indicator of a subject's average SP in daily life. Perhaps we should reexamine the current concept of daytime sleepiness and its measurement...
  64. ncbi [Differences in glycemic balance (but not weight) correlate positively with changes in absolute cardiovascular risk in diabetic patients]
    S Hadjadj
    , Centre Hospitalier Universitaire d'Angers
    Arch Mal Coeur Vaiss 93:1033-6. 2000
    ..008 and Rho = 0.019; NS, respectively). These results suggest that, in diabetic patients, changes in glycaemic control affect their CRP by an effect on total cholesterol, but the changes in body weight do not affect their CRP...
  65. ncbi Isolation and sequencing of the rho gene from Streptomyces lividans ZX7 and characterization of the RNA-dependent NTPase activity of the overexpressed protein
    C J Ingham
    Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12, United Kingdom
    J Biol Chem 271:21803-7. 1996
    ....
  66. doi Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat
    Adeleke M Badejo
    Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008
    ....
  67. ncbi The insensitivity to uncouplers of testis mitochondrial ATPase
    M E Vazquez-Memije
    Sección de Regulación Metabólica, Unidad de Investigación Biomédica del Centro Médico Nacional, Mexico
    Arch Biochem Biophys 260:67-74. 1988
    ..Since testis ATPase is known to be loosely bound to the membrane, an effect of albumin, improving tightness in the interaction of the F1 and the F0 sectors of the ATPase, is suggested...
  68. ncbi Ongoing ultradian activity rhythms in the common vole, Microtus arvalis, during deprivations of food, water and rest
    M P Gerkema
    Zoological Laboratory, Groningen University, The Netherlands
    J Comp Physiol A 168:591-7. 1991
    ..The onset of the subsequent rest episodes occurred independent of the duration of the preceding alpha'. The duration of rho' was dependent on the preceding, experimental alpha' in a periodic fashion.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. pmc Schwan equation and transmembrane potential induced by alternating electric field
    P Marszalek
    Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
    Biophys J 58:1053-8. 1990
    ..The good fit of these data to the curves calculated using the Schwan Equation indicates that the equation may be used to describe the transmembrane potential of a living cell generated by an oscillating electric field...
  70. ncbi Disc degeneration: a human cadaveric study correlating magnetic resonance imaging and quantitative discomanometry
    E P Southern
    Memorial Orthopaedic Surgical Group, Long Beach, California, USA
    Spine (Phila Pa 1976) 25:2171-5. 2000
    ..Quantitative discomanometry may be an important technique for evaluating early disc degeneration, especially tears of the anular fibers, which may be missed on magnetic resonance imaging...
  71. ncbi Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse
    Matthew Campbell
    Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Ireland
    Exp Eye Res 85:714-20. 2007
    ....
  72. pmc The Rhodobacter sphaeroides 2.4.1 rho gene: expression and genetic analysis of structure and function
    M Gomelsky
    Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, Texas 77030, USA
    J Bacteriol 178:1946-54. 1996
    ..The gene downstream of rho is homologous to thdF, whose product is involved in thiophene and furan oxidation...
  73. ncbi An assessment of the reliability of the Scoliometer
    G A Murrell
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina
    Spine (Phila Pa 1976) 18:709-12. 1993
    ..998 for the thoracic and lumbar regions, respectively). These results indicate that the Scoliometer can be a reliable noninvasive method for repetitively assessing spinal axial rotation when used by a single trained observer...
  74. ncbi Theoretical study of hydrogen bonding interaction in nitroxyl (HNO) dimer: interrelationship of the two N-H...O blue-shifting hydrogen bonds
    Ying Liu
    Key Laboratory of Environmental Optical and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, P R China
    J Phys Chem A 110:11760-4. 2006
    ..Ranging from 2.55 to 2.85 A, the cooperative ascending tendencies of the electron densities in two sigma*(N-H) with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H)...
  75. ncbi The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway
    Yasuharu Sasaki
    Department of Pharmacology, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, 108 8641, Tokyo, Japan
    Pharmacol Ther 93:225-32. 2002
    ..In this review, we address the possible role of Rho-kinase in neuronal functions, using the Rho-kinase specific inhibitor H-1152P...
  76. ncbi Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition
    Dai Yamanouchi
    Department of Vascular Surgery, Nagoya University Graduate School of Medical Sciences, Nagoya University, Japan
    J Vasc Surg 42:757-64. 2005
    ..We therefore examined the effects of a hydrophilic statin on vein graft intimal hyperplasia in vivo and Rho-kinase activity in vitro...
  77. pmc Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy
    Heba E Abdelmaksoud
    Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Exp Eye Res 88:859-79. 2009
    ..Lead hhRz 266 CUC [see in text downward arrow] proved more efficacious than Rz525/hhRz485 which infers viability for rescue of retinal degeneration in appropriate preclinical models of disease...
  78. pmc Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling
    Carlos Torre
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94121, USA
    Arch Otolaryngol Head Neck Surg 136:493-501. 2010
    ....
  79. ncbi Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis
    Kumi Kitamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 22:2022-33. 2007
    ..In this study, the involvement of the Rho/Rho kinase pathway on angiotensin II signaling in liver fibrogenesis and generation of steatosis was investigated...
  80. ncbi Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction
    Hidemi Kajimoto
    Vascular Biology Group, Alberta Cardiovascular and Stroke Research Centre ABACUS, University of Alberta, Edmonton, Canada
    Circulation 115:1777-88. 2007
    ..Subsequent membrane depolarization and calcium influx through L-type calcium channels initiates functional closure. We hypothesize that Rho-kinase activation is an additional mechanism that sustains DA constriction...
  81. ncbi [Abnormal erythrocyte sodium transport in patients with adult polycystic kidney and hypertension]
    C Guarena
    , Italie
    Arch Mal Coeur Vaiss 86:1241-3. 1993
    ....
  82. ncbi Observer variation in assessing spinal curvature and skeletal development in adolescent idiopathic scoliosis
    M S Goldberg
    Department of Epidemiology and Biostatistics, McGill University, , Canada
    Spine (Phila Pa 1976) 13:1371-7. 1988
    ..Differences in agreement between surgeons and technicians were relatively minor. These results indicate that personnel trained at this clinic are able to assess these spinal parameters reliably...
  83. pmc DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA
    J A Stuart
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Nucleic Acids Res 32:2181-92. 2004
    ....
  84. ncbi Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?
    James Bellingham
    Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, United Kingdom
    J Exp Zool B Mol Dev Evol 297:1-10. 2003
    ..of rho (which is expressed uniquely in the retina) and the closely related extraretinal rod-like opsin (exo-rhodopsin) gene, errlo (which is expressed uniquely in the pineal), in the puffer-fish, Fugu rubripes (Takifugu rubripes)...
  85. ncbi Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton
    D R Haudenschild
    Division of Arthritis Research MEM161, The Scripps Research Institute, La Jolla, CA, USA
    Biorheology 45:219-28. 2008
    ..Furthermore, we show that Rho kinase activity is required for this actin reorganization and gene expression induced by dynamic compression...
  86. ncbi Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo
    Kenichi Tokuyama
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan
    Pharmacology 64:189-95. 2002
    ..These results suggest that Y-27632 is not a useful agent in attenuating airway microvascular leakage which is seen in asthma, although it is potent in inhibiting airflow obstruction...
  87. doi Complete physicochemical characterization of DNA/chitosan complexes by multiple detection using asymmetrical flow field-flow fractionation
    Pei Lian Ma
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Anal Chem 82:9636-43. 2010
    ..This study demonstrates the ability of AF4/UV-vis/MALS+DLS to provide a complete physicochemical characterization of DNA/polycation complexes used in nonviral gene delivery...
  88. ncbi The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:25731-4. 1996
    ....
  89. doi Expression of Rho GTPases Rho-A and Rac1 in the adult and developing gerbil cerebellum
    Vaea Richard
    INSERM U 929, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000 Clermont Ferrand, France
    Int J Dev Neurosci 26:723-32. 2008
    ..In addition Rho-A is highly expressed in granule cell progenitor cells present in the external granular layer and therefore may play an important role in granule cell progenitor migration...
  90. doi Rho kinase-mediated vasoconstriction in pulmonary hypertension
    Ivan F McMurtry
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA
    Adv Exp Med Biol 661:299-308. 2010
    ..We suspect the same will be true in at least some forms of human pulmonary arterial hypertension...
  91. pmc Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors
    Stephanie J Turner
    Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, CA 92093 0652, USA
    Biochem Pharmacol 75:405-13. 2008
    ..In conclusion, we quantified effects of lovastatin on RhoA, B, and C isoforms, and provide a molecular mechanism whereby statins cause accumulation of unprenylated Rho-GTP...
  92. ncbi Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy
    Keisuke Mori
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Invest Ophthalmol Vis Sci 43:2001-6. 2002
    ..Traction retinal detachment is a central feature of both types of disease. Hemizygous rhodopsin promoter/PDGF-B (rho/PDGF-B) transgenic mice exhibit proliferation of vascular cells, glia, and retinal ..
  93. ncbi Dietary protein restriction stress in the domestic turkey (Meleagris gallopavo) induces hypofunction and remodeling of adrenal steroidogenic tissue
    R V Carsia
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford 08084, USA
    Gen Comp Endocrinol 109:140-53. 1998
    ..In addition, the present study suggests that this nutritional stressor induces marked remodeling of the steroidogenic tissue in the turkey adrenal gland...
  94. pmc Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization
    L M Machesky
    Department of Molecular Medicine, Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
    J Cell Biol 138:913-26. 1997
    ..It appears, therefore, that the assembly of large integrin complexes is not required for most of the actin reorganization or cell morphology changes induced by Rac or Rho activation in Swiss 3T3 fibroblasts...
  95. ncbi Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow
    Ponugoti Vasantha Rao
    Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Mol Vis 11:288-97. 2005
    ..This study employed a molecular approach to specifically address the role of Rho-kinase in the modulation of aqueous humor outflow...
  96. ncbi Regulation of rho-dependent transcription termination by NusG is specific to the Escherichia coli elongation complex
    Z Pasman
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, Oregon 97403, USA
    Biochemistry 39:5573-85. 2000
    ..Thus, we conclude that NusG modulates Rho-dependent termination by interacting specifically with the RNAP of the E. coli elongation complex to render the complex more susceptible to the termination activity of Rho...
  97. ncbi Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase
    Hiroki Chikumi
    Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 277:12463-73. 2002
    ....
  98. ncbi Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasion
    Yuji Nakata
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Exp Hematol 36:37-50. 2008
    ....
  99. ncbi A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    S Fukuhara
    Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 274:5868-79. 1999
    ....
  100. doi Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil
    Zen Kong Dai
    Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pediatr Pulmonol 46:45-59. 2011
    ..Further translational study in human is needed to substantiate the findings...
  101. pmc The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries
    J Eduardo da Silva-Santos
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    Crit Care Med 37:1716-23. 2009
    ..We investigated whether a reduced activity in the Rho-A/Rho-kinase pathway could be involved in the impaired vascular reactivity observed in septic shock...

Research Grants68

  1. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2010
    ..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
  2. A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis Pigmentosa
    John M Sullivan; Fiscal Year: 2010
    ..Expected results are knowledge of the minimum amount of WT human rhodopsin that is needed to keep a mammalian rod photoreceptor alive and vital. Aim 3...
  3. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip Wedegaertner; Fiscal Year: 2007
    ..abstract_text> ..
  4. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2010
    ..Results from our studies will provide insight into prevention and development of potential therapeutic strategies. ..
  5. In the Penis, RhoA Activation is Enhanced by Guanine Nucleotide Exchange Factors
    R Clinton Webb; Fiscal Year: 2010
    ..Our research has identified novel cellular events regulating constrictor responses, and an understanding of how these events can be inhibited will provide an alternative therapeutic approach to treating erectile dysfunction. ..
  6. In the Penis, RhoA Activation is Enhanced by Guanine Nucleotide Exchange Factors
    R Webb; Fiscal Year: 2009
    ..Our research has identified novel cellular events regulating constrictor responses, and an understanding of how these events can be inhibited will provide an alternative therapeutic approach to treating erectile dysfunction. ..
  7. SIGNAL TRANSDUCTION PATHWAY MEDIATING CDK5 FUNCTION
    Li Huei Tsai; Fiscal Year: 2000
    ..Rachel Neve. The second specific aim proposes to carry out studies similar to those described above, but using transfection of each of the three proteins the applicant has found to interact with cdk5 in the two hybrid screen assay. ..
  8. Myosin Phosphatase Regulation in Vascular Smooth Muscle
    HOWARD SURKS; Fiscal Year: 2007
    ..Elucidating the molecular pathways that regulate blood vessel tone is of utmost importance for understanding both normal vascular function and the major vascular diseases in our society. ..
  9. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2010
    ..The studies proposed in this application will provide this missing information. If we can learn how normal bladder is controlled, we can then design experiments to study and hopefully repair abnormal bladder ..
  10. Nitric Oxide Inhibits RhoA/Rho-kinase in Penile Erection
    R Clinton Webb; Fiscal Year: 2006
    ..These studies will define the molecular basis for NO-mediated cavernosal vasodilation in the normal state and how long-term changes in the Ca 2+ sensitizing mechanism contribute to erectile dysfunction. ..
  11. Mechanisms Driving Cortical Cytoskeleton Dynamics in Cancer Cell Invasion
    Kathryn M Eisenmann; Fiscal Year: 2010
    ..We anticipate that our experiments will shed light on basic and conserved mechanisms of cytoskeletal remodeling during various behaviors in diverse cell types. ..
  12. ROCK II-mediated regulation of centrosome duplication / centrosome amplification
    Kenji Fukasawa; Fiscal Year: 2010
    ....
  13. Sphingolipid Signaling in Endothelial Responses to Injury
    TERESA SANCHEZ GARCIA VAO; Fiscal Year: 2010
    ..Answering these questions will help us to design new drugs that inhibit or activate S1P2R, which could be used as new therapies to alleviate the symptoms of atherosclerosis, diabetes or sepsis. ..
  14. Rho-Dependent COX-2 Expression in Intestinal Cells
    Lee Slice; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  15. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2010
    ....
  16. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ....
  17. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Rao; Fiscal Year: 2009
    ....
  18. Role of Rho Kinase in Aqueous Humor Outflow Pathway
    P Rao; Fiscal Year: 2004
    ..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
  19. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2010
    ..We plan to use the Kalirin-7 knockout mouse that we generated to elucidate the pathway(s) controlling spine formation and structure. ..
  20. Mechanism and role of DLC-1 tumor suppressor loss in lung cancer
    Channing J Der; Fiscal Year: 2010
    ..Hence, we believe that our elucidation of the mechanism by which DLC-1 loss may deregulate Rho GTPases and promote NSCLC growth may define novel directions for targeted therapies for lung cancer treatment. ..
  21. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah Glover; Fiscal Year: 2009
    ....
  22. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah C Glover; Fiscal Year: 2010
    ....
  23. G Proteins and Endothelial Barrier Regulation
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2004
    ..abstract_text> ..
  24. Statins and VEGF-induced cytoskeletal remodeling
    FARHAD DANESH; Fiscal Year: 2009
    ..abstract_text> ..
  25. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 2009
    ..The overall goal of our proposal is to illustrate the mechanisms to provide a deeper understanding regarding the pathogenesis of glaucomas. ..
  26. STRUCTURE/FUNCTION OF FOCAL ADHESIONS
    Keith Burridge; Fiscal Year: 2000
    ..The effect of vinculin on PIP2 hydrolysis will be studied. We will determine which domain of vinculin restores anchorage-dependent growth when transfected into cells with reduced vinculin expression. ..
  27. Rho- and GPCR-mediated signaling through novel cellular effectors
    Joan Heller Brown; Fiscal Year: 2010
    ....