Gene Symbol: RHAMM
Description: hyaluronan mediated motility receptor
Alias: CD168, IHABP, RHAMM, hyaluronan mediated motility receptor, intracellular hyaluronic acid-binding protein, receptor for hyaluronan-mediated motility
Species: human
Products:     RHAMM

Top Publications

  1. Assmann V, Marshall J, Fieber C, Hofmann M, Hart I. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. J Cell Sci. 1998;111 ( Pt 12):1685-94 pubmed
    ..findings lead us to conclude that RHAMM does not function as a conventional motility receptor for HA in human breast cancer cells and we suggest the term RHAMM be substituted by 'intracellular hyaluronic acid binding protein' (IHABP).
  2. Maxwell C, Keats J, Belch A, Pilarski L, Reiman T. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Cancer Res. 2005;65:850-60 pubmed
    Elevated expression of receptor for hyaluronan-mediated motility (RHAMM) within ex vivo diagnostic multiple myeloma plasma cells predicts for aggressive disease and patient survival...
  3. Maxwell C, McCarthy J, Turley E. Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?. J Cell Sci. 2008;121:925-32 pubmed publisher
    ..of unconventional cytoplasmic-protein export by focusing on the mitotic-spindle/hyaluronan-binding protein RHAMM, which is hyper-expressed in many human tumors...
  4. Yamano Y, Uzawa K, Shinozuka K, Fushimi K, Ishigami T, Nomura H, et al. Hyaluronan-mediated motility: a target in oral squamous cell carcinoma. Int J Oncol. 2008;32:1001-9 pubmed
    ..mapped to the cancer-related network with the highest significance, the receptor for hyaluronan-mediated motility (RHAMM) was evaluated further for mRNA and protein expression in the OSCC cell lines, primary OSCCs...
  5. Zlobec I, Baker K, Terracciano L, Lugli A. RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis. Clin Cancer Res. 2008;14:3798-806 pubmed publisher
    ..Seven clinicopathologic features and all tumor markers were evaluated in univariate and multivariable analyses. RHAMM overexpression [P < 0.001; hazard ratio [HR; 95% confidence interval (95% CI)], 3.86 (2.19-6...
  6. Kalmyrzaev B, Pharoah P, Easton D, Ponder B, Dunning A. Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:3618-20 pubmed publisher
    ..87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6]. ..
  7. Nagel S, Hirschmann P, Dirnhofer S, Gunthert U, Tzankov A. Coexpression of CD44 variant isoforms and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) is an International Prognostic Index and C-MYC gene status-independent predictor of poor outcome in diffuse large B-cell lymphomas. Exp Hematol. 2010;38:38-45 pubmed publisher
    ..We showed that coexpression of any of the CD44v with the receptor for hyaluronic acid-mediated motility (RHAMM, CD168) identifies a subgroup of DLBCL patients with a very poor prognosis, independent of the International Prognostic ..
  8. Assmann V, Jenkinson D, Marshall J, Hart I. The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments. J Cell Sci. 1999;112 ( Pt 22):3943-54 pubmed
    We reported recently on the intracellular localisation of the hyaluronan receptor RHAMM/IHABP in human cancer cells...
  9. Maxwell C, Keats J, Crainie M, Sun X, Yen T, Shibuya E, et al. RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell. 2003;14:2262-76 pubmed
    The receptor for hyaluronan-mediated motility (RHAMM), an acidic coiled coil protein, has previously been characterized as a cell surface receptor for hyaluronan, and a microtubule-associated intracellular hyaluronan binding protein...

More Information

Publications146 found, 100 shown here

  1. Sohr S, Engeland K. RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. Cell Cycle. 2008;7:3448-60 pubmed
    The receptor for hyaluronan-mediated motility RHAMM exerts different functions in the cell as well as on the cell membrane...
  2. Gust K, Hofer M, Perner S, Kim R, Chinnaiyan A, Varambally S, et al. RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease. Neoplasia. 2009;11:956-63 pubmed
    ..The RHAMM (CD168) gene, earlier identified by our group as an immunogenic antigen in acute and chronic leukemia, also showed ..
  3. Huang T, Cheng P, Chan Y, Yeh T, Young Y, Young T. Regulation of ciliary differentiation of human respiratory epithelial cells by the receptor for hyaluronan-mediated motility on hyaluronan-based biomaterials. Biomaterials. 2010;31:6701-9 pubmed publisher
    ..that on collagen with/without RA, this study elucidates the role of the receptor for hyaluronan-mediated motility (RHAMM) in promoting ciliary differentiation of RECs...
  4. Maxwell C, Benitez J, Gómez Baldó L, Osorio A, Bonifaci N, Fernández Ramires R, et al. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011;9:e1001199 pubmed publisher
    ..Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer...
  5. Hamilton S, Fard S, Paiwand F, Tolg C, Veiseh M, Wang C, et al. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem. 2007;282:16667-80 pubmed
    CD44 is an integral hyaluronan receptor that can promote or inhibit motogenic signaling in tumor cells. Rhamm is a nonintegral cell surface hyaluronan receptor (CD168) and intracellular protein that promotes cell motility in culture...
  6. Pujana M, Han J, Starita L, Stevens K, Tewari M, Ahn J, et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007;39:1338-49 pubmed
    ..Our network modeling strategy should be useful for the discovery of additional cancer-associated genes. ..
  7. Lin S, Chang D, Chiang A, Ying S. Androgen receptor regulates CD168 expression and signaling in prostate cancer. Carcinogenesis. 2008;29:282-90 pubmed publisher
    ..Previous studies have shown that activation of the receptor for hyaluronan-mediated motility, CD168, was correlated with the Gleason's score, cancer stage, transformation and metastasis in >90% of HRPC patients...
  8. Fiscon G, Conte F, Paci P. SWIM tool application to expression data of glioblastoma stem-like cell lines, corresponding primary tumors and conventional glioma cell lines. BMC Bioinformatics. 2018;19:436 pubmed publisher
    ..We suggest FOSL1 as novel putative therapeutic and prognostic biomarker, worthy of further investigation. ..
  9. Rezvani K, de Lavallade H. Vaccination strategies in lymphomas and leukaemias: recent progress. Drugs. 2011;71:1659-74 pubmed publisher
    ..clinical trials of vaccination with peptides derived from a number of leukaemia antigens, including WT1, PR1, RHAMM and BCR-ABL, have shown evidence of immunogenicity, but limited data are available on the clinical efficacy of ..
  10. Wu J, Qu Y, Zhang Y, Deng J, Yu Q. RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes. BMC Musculoskelet Disord. 2018;19:455 pubmed publisher
    ..b>Receptor for hyaluronan mediated motility (RHAMM), is known to be one of the important receptors for hyaluronic acid...
  11. Price Z, Lokman N, Ricciardelli C. Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance. Cancers (Basel). 2018;10: pubmed publisher
    ..HA interacts with multiple cell surface receptors, including CD44, receptor for hyaluronan mediated motility (RHAMM) and intracellular signaling pathways, including receptor tyrosine kinase pathways, to ..
  12. Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher
    ..This study provides rationale for investigation of HMMR, HOXC6, IGF1, MAP4K4, SIAH2, and SMAD4 as biomarkers of PCa aggressiveness in larger cohorts. ..
  13. Tolg C, Yuan H, Flynn S, Basu K, Ma J, Tse K, et al. Hyaluronan modulates growth factor induced mammary gland branching in a size dependent manner. Matrix Biol. 2017;63:117-132 pubmed publisher
    ..HA accumulation and expression of the HA receptors CD44 and RHAMM are highest during gestation when gland remodeling, lateral branch infilling and lobulo-alveoli formation is ..
  14. Markasz L, Savani R, Sedin G, Sindelar R. The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content. Early Hum Dev. 2018;127:58-68 pubmed publisher
    Hyaluronan (HA) and the receptor for hyaluronan-mediated motility (RHAMM) may play an important role in lung development...
  15. Leng Y, Abdullah A, Wendt M, Calve S. Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis. Matrix Biol. 2018;: pubmed publisher
    ..which HA mediates embryonic myogenesis, we first determined the spatial distribution and gene expression of CD44, RHAMM and other HA related proteins in embryonic day (E)10.5 to E12.5 murine forelimbs...
  16. Al Alawneh M, Nuaimi N, Basheti I. Pharmacists in humanitarian crisis settings: Assessing the impact of pharmacist-delivered home medication management review service to Syrian refugees in Jordan. Res Social Adm Pharm. 2019;15:164-172 pubmed publisher
    ..Identified TRPs are high amongst Syrian refugees living in Jordan. The HMMR service significantly reduced the number of TRPs, and was highly accepted by the physicians. Refugees reported high satisfaction with this service. ..
  17. Song Y, Tan J, Gao X, Wang L. Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma. Cancer Manag Res. 2018;10:6097-6108 pubmed publisher
    ..DEGs, including AURKB, BUB1B, KIF2C, HMMR, CENPF, and CENPU, might be potential biomarkers for the prognosis and treatment of lung adenocarcinoma. ..
  18. Chu Z, Dai J, Jia L, Li J, Zhang Y, Zhang Z, et al. Increased expression of long noncoding RNA HMMR-AS1 in epithelial ovarian cancer: an independent prognostic factor. Eur Rev Med Pharmacol Sci. 2018;22:8145-8150 pubmed publisher
    ..Our data suggested that HMMR-AS1 may be considered a novel prognostic factor in EOC and a specific diagnostic indicator for patients with EOC. ..
  19. Alam M, Han H, Sung S, Kang J, Sa K, Al Faruque H, et al. Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis. J Control Release. 2017;252:62-72 pubmed publisher
    ..in macrophages which involved molecular redundancy among major hyaladherins, including CD44, stabilin-2, and RHAMM. Following endocytosis, MP-HANPs loaded with doxorubicin revealed pH-dependent demineralization followed by ..
  20. Scrofani J, Sardon T, Meunier S, Vernos I. Microtubule nucleation in mitosis by a RanGTP-dependent protein complex. Curr Biol. 2015;25:131-40 pubmed publisher
    ..The resulting TPX2-RHAMM-γTuRC supracomplex fulfills the two essential requirements for the activation of MT nucleation by RanGTP: NEDD1 ..
  21. Kolliopoulos C, Lin C, Heldin C, Moustakas A, Heldin P. Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGF?-induced EMT in breast cancer. Matrix Biol. 2018;: pubmed publisher
    ..Our findings show that Has2as has a key role in TGF?- and HAS2-induced breast cancer EMT, migration and acquisition of stemness. ..
  22. Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, et al. Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol. 2008;15:1246-54 pubmed publisher
    ..Because Bach1 is regulated by oxidative stress and heme, our data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53. ..
  23. Stafford J, Dyson G, Levin N, Chaudhry S, Rosati R, Kalpage H, et al. Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability. PLoS ONE. 2017;12:e0178450 pubmed publisher
    ..In summary, our study implicates novel risk loci as well as highlights the clinical utility for retesting BRCA1/2 negative OVCA patients by genomic sequencing and analysis of genes in relevant pathways. ..
  24. Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, et al. Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. Int J Oncol. 2009;34:1565-71 pubmed
    Receptor for hyaluronan-mediated motility (RHAMM) has previously been characterized as a cell surface receptor for hyaluronan and a microtubule-associated intracellular hyaluronan binding protein...
  25. Li H, Frappart L, Moll J, Winkler A, Kroll T, Hamann J, et al. Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma. Cancer Res. 2016;76:6382-6395 pubmed
    ..Oriented divisions of germ cells, which determine their fate, were regulated by spindle-associated RHAMM-a function we found to be abolished in 96% of human seminomas...
  26. Hare A, Harris E. Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen. Biochem Biophys Res Commun. 2015;456:257-61 pubmed publisher
    ..between alternative splice variants and cancer progression has been shown in other HA receptors such as RHAMM and CD42. In this study, two methods were utilized in identifying and/or isolating the HARE splice variants...
  27. Choudhary M, Zhang X, Stojkovic P, Hyslop L, Anyfantis G, Herbert M, et al. Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. Stem Cells. 2007;25:3045-57 pubmed
    ..HA and its binding protein RHAMM regulate various cellular and hydrodynamic processes from cell migration, proliferation, and signaling to ..
  28. Villegas Ruiz V, Salcedo M, Zentella Dehesa A, de Oca E, Román Basaure E, Mantilla Morales A, et al. A case of cervical cancer expressed three mRNA variant of Hyaluronan-mediated motility receptor. Int J Clin Exp Pathol. 2014;7:2256-64 pubmed
    ..Hyaluronan-mediated motility receptor (HMMR, RHAMM, CD168) is a family member of proteins, hyaluronan acid dependent, and has been associated with different malignant ..
  29. Karbownik M, Nowak J. Hyaluronan: towards novel anti-cancer therapeutics. Pharmacol Rep. 2013;65:1056-74 pubmed
    ..data on hyaluronan biosynthesis, metabolism, and interactions with its binding proteins called hyaladherins (CD44, RHAMM), providing themolecular background underlying its differentiated biological activity...
  30. He Z, Kannan N, Nemirovsky O, Chen H, Connell M, Taylor B, et al. BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells. Oncotarget. 2017;8:32461-32475 pubmed publisher
  31. Chang C, Nashchekin D, Wheatley L, Irion U, Dahlgaard K, Montague T, et al. Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors. Genetics. 2011;188:883-96 pubmed publisher
    ..This has an almost identical sequence to the N terminus of vertebrate RHAMM, which is also a large coiled-coil protein, suggesting that it may be a divergent Miranda ortholog...
  32. Sullivan W, Mullen P, Schmid E, Flores A, Momcilovic M, Sharpley M, et al. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018;175:117-132.e21 pubmed publisher
    ..This interconnection between ECM remodeling and metabolism is exhibited in dynamic tissue states, including tumorigenesis and embryogenesis. ..
  33. Akent eva N, Shushanov S, Kotel nikov A. Effects of RHAMM/HMMR-Selective Peptides on Survival of Breast Cancer Cells. Bull Exp Biol Med. 2015;159:658-61 pubmed publisher
    b>RHAMM-selective peptides in a concentration of 10 μg/ml (2×10(-7) M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h...
  34. Connell M, Chen H, Jiang J, Kuan C, Fotovati A, Chu T, et al. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. elife. 2017;6: pubmed publisher
    ..These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development. ..
  35. Virga J, Bognar L, Hortobagyi T, Zahuczky G, Csosz E, Kalló G, et al. Tumor Grade versus Expression of Invasion-Related Molecules in Astrocytoma. Pathol Oncol Res. 2018;24:35-43 pubmed publisher
    ..ErbB2, fibronectin, integrin-?1 and versican discriminates low-grade from high-grade gliomas, of proteins RHAMM, integrin-?1 and MMP2 seems important...
  36. Torabi F, Bogle O, Estanyol J, Oliva R, Miller D. Zona pellucida-binding protein 2 (ZPBP2) and several proteins containing BX7B motifs in human sperm may have hyaluronic acid binding or recognition properties. Mol Hum Reprod. 2017;23:803-816 pubmed publisher
    ..The presence of BX7B sequence motifs found in several well-described hyaladherins including RHAMM was used to assess efficacy of potential hyaladherin partitioning by the HA substrate...
  37. Meier C, Spitschak A, Abshagen K, Gupta S, Mor J, Wolkenhauer O, et al. Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin. J Pathol. 2014;234:351-64 pubmed publisher
    ..circulating tumour cells (CTCs) relies on a novel function of the hyaluronan-mediated motility receptor RHAMM. E2F1 directly up-regulates RHAMM, which in turn acts as a co-activator of E2F1 to stimulate expression of the ..
  38. Soulié P, Chassot A, Ernandez T, Montesano R, Féraille E. Spatially restricted hyaluronan production by Has2 drives epithelial tubulogenesis in vitro. Am J Physiol Cell Physiol. 2014;307:C745-59 pubmed publisher
    ..However, silencing of either CD44 or RHAMM (receptor for HA-mediated motility), the major HA receptors, by RNA interference, did not alter tubulogenesis, ..
  39. Dunsch A, Hammond D, Lloyd J, Schermelleh L, Gruneberg U, Barr F. Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. J Cell Biol. 2012;198:1039-54 pubmed publisher
    ..These findings support a model where DYNLL1 and CHICA-HMMR form part of the regulatory system feeding back spindle position to dynein at the cell cortex. ..
  40. Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A. 2014;111:E89-98 pubmed publisher
    Expression of receptor for hyaluronan-mediated motility (RHAMM), a breast cancer susceptibility gene, is tightly controlled in normal tissues but elevated in many tumors, contributing to tumorigenesis and metastases...
  41. Li H, Moll J, Winkler A, Frappart L, Brunet S, Hamann J, et al. RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biol Open. 2015;4:562-71 pubmed publisher
    ..of the oocyte-granulosa cell complex, we deleted the relevant domain of the Receptor for HA Mediated Motility (RHAMM) gene in the mouse...
  42. Chen H, Connell M, Mei L, Reid G, Maxwell C. The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation. Mol Biol Cell. 2018;: pubmed publisher
    ..Together, our findings indicate that HMMR balances Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation. ..
  43. Huan J, Gao X, Xing L, Qin X, Qian H, Zhou Q, et al. Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis. Genet Mol Res. 2014;13:7919-25 pubmed publisher
    ..More importantly, some key genes were revealed via gene coexpression network analysis, which could be potential biomarkers for IDC of the breast. ..
  44. Pradhan R, Ramasamy T, Choi J, Kim J, Poudel B, Tak J, et al. Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin. Carbohydr Polym. 2015;123:313-23 pubmed publisher
    ..Furthermore, synergistic antitumor activity was demonstrated in vivo in a CD44 and RHAMM (CD168) - overexpressing squamous cell carcinoma (SCC-7) xenograft in nude mice...
  45. Willemen Y, Van den Bergh J, Bonte S, Anguille S, Heirman C, Stein B, et al. The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells. Oncotarget. 2016;7:73960-73970 pubmed publisher
    ..Here, we investigated whether we could introduce the receptor for hyaluronic acid-mediated motility (RHAMM/HMMR/CD168), another clinically relevant tumor-associated antigen, into these mo-DCs through mRNA electroporation and elicit ..
  46. Zhang H, Huang S, Yang X, Zhai G. Current research on hyaluronic acid-drug bioconjugates. Eur J Med Chem. 2014;86:310-7 pubmed publisher
    ..In addition, multifarious receptors of HA like CD44, RHAMM and TSG6 are over-expressed on the surface of malignant cells, which play important roles in targeting ability...
  47. Yeh M, Tzeng Y, Fu T, You J, Chang H, Ger L, et al. Extracellular Matrix-receptor Interaction Signaling Genes Associated with Inferior Breast Cancer Survival. Anticancer Res. 2018;38:4593-4605 pubmed publisher
    ..29, 95%CI=1.52-7.12, p=0.003). These findings suggest that HMMR and SDC1 involved in the ECM-receptor interaction signaling pathway could act as effective independent prognostic biomarkers for breast ductal carcinoma. ..
  48. Aziz K. CD44 mediates polymorphonuclear leukocyte motility on hyaluronan. Saudi Med J. 2003;24:827-31 pubmed
    ..with blocking and non-blocking antibodies against cluster of differentiation 44 (CD44) and Receptor for Hyaluronan Mediated Motility (RHAMM) prior to addition to HA-coated surfaces...
  49. Symonette C, Kaur Mann A, Tan X, Tolg C, Ma J, Perera F, et al. Hyaluronan-phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation. Biomed Res Int. 2014;2014:727459 pubmed publisher
    ..HA-PE) polymers that form pericellular coats around cultured dermal fibroblasts independently of CD44 or RHAMM display...
  50. Pilarski L, Pruski E, Wizniak J, Paine D, Seeberger K, Mant M, et al. Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. Blood. 1999;93:2918-27 pubmed
    ..were compared with steady-state BM for their ability to bind hyaluronan (HA), their expression of the HA receptors RHAMM and CD44, and their motogenic behavior...
  51. Niedworok C, Panitz M, Szarvas T, Reis H, Reis A, Szendroi A, et al. Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis. J Urol. 2016;195:1690-6 pubmed publisher
    ..and prognostic relevance of 6 select protein markers of urachal carcinoma of the bladder, including p53, Ki67, RHAMM, BGN, IMP3 and MMP-7, which were formerly shown to be prognostic in urothelial carcinoma and colorectal ..
  52. Mele V, Sokol L, Kölzer V, Pfaff D, Muraro M, Keller I, et al. The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer. Oncotarget. 2017;8:70617-70629 pubmed publisher
    In colorectal cancer (CRC), RHAMM is an independent adverse prognostic factor...
  53. Nikitovic D, Berdiaki A, Banos A, Tsatsakis A, Karamanos N, Tzanakakis G. Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma?. Curr Med Chem. 2013;20:2868-80 pubmed
    ..matrix macromolecules, such as secreted and cell-associated proteoglycans, hyaluronan and its receptors CD44 and RHAMM, as well as the expression and activity of matrix- degrading metalloproteinases, which are of critical importance ..
  54. Zhou W, Yin M, Cui H, Wang N, Zhao L, Yuan L, et al. Identification of potential therapeutic target genes and mechanisms in non-small-cell lung carcinoma in non-smoking women based on bioinformatics analysis. Eur Rev Med Pharmacol Sci. 2015;19:3375-84 pubmed
    ..Genes such as HMMR, COL1A2, CCNA2, MAD2L1, IL6 and IL1B may be potential therapeutic target genes for NSCLC. ..
  55. Stangeland B, Mughal A, Grieg Z, Sandberg C, Joel M, Nygård S, et al. Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells. Oncotarget. 2015;6:26192-215 pubmed publisher
    ..filtering identified 20 genes (PBK/TOPK, CENPA, KIF15, DEPDC1, CDC6, DLG7/DLGAP5/HURP, KIF18A, EZH2, HMMR/RHAMM/CD168, NOL4, MPP6, MDM1, RAPGEF4, RHBDD1, FNDC3B, FILIP1L, MCC, ATXN7L4/ATXN7L1, P2RY5/LPAR6 and FAM118A) that were ..
  56. Wartenberg M, Cibin S, Zlobec I, Vassella E, Eppenberger Castori S, Terracciano L, et al. Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. Clin Cancer Res. 2018;24:4444-4454 pubmed publisher
    ..tissue microarrays were immunostained for CD3, CD4, CD8, CD20, PD-L1, p63, hyaluronan-mediated motility receptor (RHAMM), and DNA mismatch repair proteins. Previous data on FOXP3 were integrated...
  57. Luczynski W, Kowalczuk O, Stasiak Barmuta A, Ilendo E, Krawczuk Rybak M, Chyczewski L. Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1. Neoplasma. 2009;56:428-34 pubmed
    ..The results of the study showed maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells...
  58. Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, et al. RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia. Haematologica. 2012;97:1539-47 pubmed publisher
    ..It was shown in vaccination trials that Receptor for Hyaluronic Acid Mediated Motility (RHAMM/HMMR) generates cellular immune responses in patients with acute myeloid leukemia and that these responses ..
  59. Stevens L, Cheung W, Adua S, Arnal Estapé A, Zhao M, Liu Z, et al. Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases. Cancer Res. 2017;77:1905-1917 pubmed publisher
    ..Our findings reveal an important mechanism by which disseminated cancer cells can coopt the inflammatory ECM to persist, leading to brain metastatic outgrowths. Cancer Res; 77(8); 1905-17. ©2017 AACR. ..
  60. Chu T, Connell M, Zhou L, He Z, Won J, Chen H, et al. Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Mol Cancer Res. 2018;16:16-31 pubmed publisher
    ..i>Mol Cancer Res; 16(1); 16-31. ©2017 AACR. ..
  61. Mohan P, Castellsagué J, Jiang J, ALLEN K, Chen H, Nemirovsky O, et al. Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Oncotarget. 2013;4:80-93 pubmed
    ..the activity of the kinase, which correlates with the expression of the regulatory gene products TPX2 and HMMR/RHAMM. Silencing of HMMR/RHAMM, but not TPX2, augments AURKA activity and sensitizes MPNST cells to AKI...
  62. Li P, Xiang T, Li H, Li Q, Yang B, Huang J, et al. Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer. Int J Clin Exp Pathol. 2015;8:12101-14 pubmed
    ..cell adhesion, migration and proliferation by interacting with specific cell surface receptors such as CD44 and RHAMM. HA synthase 2 (HAS2) catalyzes the synthesis of HA, but its role in breast tumorigenesis remains unclear...
  63. Niedworok C, Kretschmer I, Röck K, vom Dorp F, Szarvas T, Heß J, et al. The impact of the receptor of hyaluronan-mediated motility (RHAMM) on human urothelial transitional cell cancer of the bladder. PLoS ONE. 2013;8:e75681 pubmed publisher
    ..mRNA-expression levels of HA synthases (HAS1-3) and HA-receptors (RHAMM and CD44) were evaluated by real time RT-PCR in comparison to healthy bladder tissue as control...
  64. Liu W, Ma J, Cheng Y, Zhang H, Luo W, Zhang H. HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells. Breast Cancer (Dove Med Press). 2016;8:223-229 pubmed
    ..1) influenced the progression of BLBCs through regulating HMMR, suggesting that HMMR-AS1 (RP11-80G.1) could be regarded as a novel biomarker and therapeutic target in the treatment of BLBCs in future. ..
  65. Lee Y, Chang Y, Wu C, Huang C. Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain. Mol Neurobiol. 2018;55:7743-7757 pubmed publisher
    ..Thus, cell therapy by using hypoxic HUVECs that enhance migration and neurovascular protection may provide an effective therapeutic strategy for treating neonatal asphyxia. ..
  66. Tzankov A, Leu N, Muenst S, Juskevicius D, Klingbiel D, Mamot C, et al. Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study. J Hematol Oncol. 2015;8:70 pubmed publisher
    ..Immunohistochemical (bcl2, bcl6, CD5, CD10, CD20, CD95, CD168, cyclin E, FOXP1, GCET, Ki-67, LMO2, MUM1p, pSTAT3) and in situ hybridization analyses (BCL2 break apart probe, C-..
  67. Katona E, Juhasz T, Somogyi C, Hajdú T, Szász C, Rácz K, et al. PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines. Int J Oncol. 2016;48:983-97 pubmed publisher
    ..As the expression of the HA receptor RHAMM was also significantly enhanced by PD098059, the MAPK pathway exerted a complex attenuating effect on HA ..
  68. Krishnamurthy V, Stout A, Sapp M, Matuska B, Lauer M, Grande Allen K. Dysregulation of hyaluronan homeostasis during aortic valve disease. Matrix Biol. 2017;62:40-57 pubmed publisher
    ..with increased collagen and HYAL to HAS ratio, and site-specific abnormalities in the expression of CD44 and RHAMM receptors...
  69. Wang C, Entwistle J, Hou G, Li Q, Turley E. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. Gene. 1996;174:299-306 pubmed
    A full-length human RHAMM cDNA clone was isolated by a combination of screening a human breast cDNA expression library with the murine RHAMM 2 cDNA as well as 5' RACE and RT-PCR using messenger RNA from human breast cell line (MCF-10A)...
  70. Lynn B, Li X, Cattini P, Nagy J. Sequence, protein expression and extracellular-regulated kinase association of the hyaladherin RHAMM (receptor for hyaluronan mediated motility) in PC12 cells. Neurosci Lett. 2001;306:49-52 pubmed
    ..We investigated the involvement of receptor for hyaluronan mediated motility (RHAMM) in this signaling pathway. A single RHAMM 3.2 kb transcript was detected in PC12 RNA...
  71. Brayer J, Pinilla Ibarz J. Developing strategies in the immunotherapy of leukemias. Cancer Control. 2013;20:49-59 pubmed
    ..such as the Wilms' tumor gene 1 (WT1), proteinase 3 (PR3), and receptor for hyaluronan acid-mediated motility (RHAMM) is provided. Cell-based vaccination strategies are also briefly explored...
  72. Valori M, Jansson L, Kiviharju A, Ellonen P, Rajala H, Awad S, et al. A novel class of somatic mutations in blood detected preferentially in CD8+ cells. Clin Immunol. 2017;175:75-81 pubmed publisher
    ..Whether some of this class of mutations plays a role in disease is currently unclear, but these results define an interesting hitherto unknown research target for future studies. ..
  73. Eibes S, Gallisà Suñé N, Rosas Salvans M, Martínez Delgado P, Vernos I, Roig J. Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown. Curr Biol. 2018;28:121-129.e4 pubmed publisher
    ..This localization involves RHAMM/HMMR [19] and the kinase Nek9 [20], which phosphorylates TPX2 nuclear localization signal (NLS) preventing its ..
  74. Greiner J, Ringhoffer M, Taniguchi M, Schmitt A, Kirchner D, Krähn G, et al. Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia. Exp Hematol. 2002;30:1029-35 pubmed
    ..The receptor for hyaluronan acid-mediated motility (RHAMM) involved in cell growth and metastasis was identified as a new LAA...
  75. Manzanares D, Monzon M, Savani R, Salathe M. Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON. Am J Respir Cell Mol Biol. 2007;37:160-8 pubmed
    ..A functionally blocking antibody to the receptor for hyaluronic acid-mediated motility (RHAMM) reduced the CBF response to X/XO...
  76. García Posadas L, Contreras Ruiz L, Arranz Valsero I, López García A, Calonge M, Diebold Y. CD44 and RHAMM hyaluronan receptors in human ocular surface inflammation. Graefes Arch Clin Exp Ophthalmol. 2014;252:1289-95 pubmed publisher
    CD44 and RHAMM hyaluronan (HA) receptors have been studied in several systemic diseases such as osteoarthritis and cancer. However, not too much is known about their role in ocular surface disorders...
  77. Missinato M, Tobita K, Romano N, Carroll J, Tsang M. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovasc Res. 2015;107:487-98 pubmed publisher
    ..HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration. ..
  78. Mascaró M, Pibuel M, Lompardía S, Díaz M, Zotta E, Bianconi M, et al. Low molecular weight hyaluronan induces migration of human choriocarcinoma JEG-3 cells mediated by RHAMM as well as by PI3K and MAPK pathways. Histochem Cell Biol. 2017;148:173-187 pubmed publisher
    ..the role of HA in the pathogenesis of GTD by defining the expression pattern of HA and its receptors CD44 and RHAMM, as well as to determine if HA can modulate proliferation, differentiation and migration of CC cells...
  79. Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, et al. Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR. Biochem J. 2018;475:981-1002 pubmed publisher
  80. Tilghman J, Wu H, Sang Y, Shi X, Guerrero Cazares H, Quinones Hinojosa A, et al. HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res. 2014;74:3168-79 pubmed publisher
    ..In human GBM tumor specimens, HMMR expression is correlated positively with the expression of stemness-associated markers and regulators. Our findings identify HMMR as a candidate therapeutic target to GSCs as a GBM treatment strategy. ..
  81. Koelzer V, Huber B, Mele V, Iezzi G, Trippel M, Karamitopoulou E, et al. Expression of the hyaluronan-mediated motility receptor RHAMM in tumor budding cells identifies aggressive colorectal cancers. Hum Pathol. 2015;46:1573-81 pubmed publisher
    Expression of the hyaluronan-mediated motility receptor (RHAMM, CD168) predicts adverse clinicopathological features and decreased survival for colorectal cancer (CRC) patients...
  82. Nikitovic D, Kouvidi K, Kavasi R, Berdiaki A, Tzanakakis G. Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer. Curr Drug Deliv. 2016;13:500-11 pubmed
    ..proteins, called hyaladherins, including CD44 receptor as well as receptor for hyaluronan-mediated motility (RHAMM). HA binding can be followed by receptor-mediated endocytosis...
  83. Oldenburg D, Ru Y, Weinhaus B, Cash S, Theodorescu D, Guin S. CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL). BMC Cancer. 2016;16:713 pubmed publisher
    ..However the role of HA receptors CD44 and Hyaluronan Mediated Motility Receptor (RHAMM) in regulating the growth of bladder cancer cells driven by loss of AGL has not been ..
  84. Savani R, Cao G, Pooler P, Zaman A, Zhou Z, DeLisser H. Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J Biol Chem. 2001;276:36770-8 pubmed
    ..through binding interactions with at least two cell surface receptors: CD44 and receptor for HA-mediated motility (RHAMM)...
  85. Cruijsen M, Hobo W, van der Velden W, Bremmers M, Woestenenk R, Bär B, et al. Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses. Biol Blood Marrow Transplant. 2016;22:1000-1008 pubmed publisher
    ..silenced tumor-associated antigens (TAAs), including cancer-testis antigens (MAGE-A1/A2/A3 and PRAME) and RHAMM, occurred more frequently in patients who had received Dec/Flu/TBI conditioning (8 of 11 patients) compared with a ..
  86. Barzilay R, Ventorp F, Segal Gavish H, Aharony I, Bieber A, Dar S, et al. CD44 Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like Behavior in Mice. J Mol Neurosci. 2016;60:548-558 pubmed
    ..The hippocampal expression of the receptor for HA-mediated motility (RHAMM) was reduced in the non- stressed CD44KO mice compared with WT mice, in a value similar to that observed in WT ..
  87. Li J, Ji X, Wang H. Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma. Neoplasia. 2018;20:456-466 pubmed publisher
    ..Our data demonstrate a mechanism of sense-antisense interference between HMMR and HMMR-AS1 in GBM and suggest that targeting HMMR-AS1 is a potential strategy for GBM treatment. ..
  88. Lokeshwar V, Selzer M. Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells. J Biol Chem. 2000;275:27641-9 pubmed
    ..All three ECs expressed CD44 ( approximately 110 kDa). The expression of receptor for HA-mediated motility (RHAMM) (approximately 80 kDa) was the highest in HMVEC-L, followed by HPAEC and human umbilical vein ECs...
  89. Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T, et al. Prognostic impact of CD168 expression in gastric cancer. BMC Cancer. 2011;11:106 pubmed publisher
    Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and ..
  90. Gurski L, Xu X, Labrada L, Nguyen N, Xiao L, van Golen K, et al. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. PLoS ONE. 2012;7:e50075 pubmed publisher
    ..culture in the HA hydrogel triggers invasive PCa cells to differentially express and localize receptor for hyaluronan mediated motility (RHAMM)/CD168 which, in the absence of CD44, appears to contribute to PCa motility and invasion ..
  91. Yamasaki C, Tashiro S, Nishito Y, Sueda T, Igarashi K. Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP. J Biochem. 2005;137:287-96 pubmed
    ..By means of a yeast two hybrid screening using Bach1 as bait, we identified the intracellular hyaluronic acid binding protein (IHABP) as a potential regulator of Bach1...