RGS7

Summary

Gene Symbol: RGS7
Description: regulator of G-protein signaling 7
Alias: regulator of G-protein signaling RGS7, regulator of G-protein signalling 7
Species: human

Top Publications

  1. doi RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11
    Yasar Saleem
    Center for Neural Science, Korea Institute of Science and Technology KIST, P O BOX 131, Cheongryang, Seoul 130 650, Republic of Korea
    Biochem Biophys Res Commun 386:65-70. 2009
  2. ncbi Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter
    Javier Garzón
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, E 28002 Madrid, Spain
    Neuropharmacology 48:853-68. 2005
  3. pmc Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family
    Ryan M Drenan
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 169:623-33. 2005
  4. ncbi New dimensions in G protein signalling: G beta 5 and the RGS proteins
    W F Simonds
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pharm Acta Helv 74:333-6. 2000
  5. ncbi Enhancement of pheromone response by RGS9 and Gbeta5 in yeast
    Seena K Ajit
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543, USA
    Biochem Biophys Res Commun 324:686-91. 2004
  6. pmc Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907
    Rakesh K Singh
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    Int J Neuropsychopharmacol 12:651-65. 2009
  7. pmc Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release
    R K Singh
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    J Psychopharmacol 24:1079-88. 2010
  8. ncbi Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain
    Tatsuya Ingi
    Department of Neurophysiology, Brain Research Institute, Niigata University, 1 Asahi machi, Niigata 951 8585, Japan
    Eur J Neurosci 15:929-36. 2002
  9. pmc RGS7 and -11 complexes accelerate the ON-bipolar cell light response
    Jianmei Zhang
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington, USA
    Invest Ophthalmol Vis Sci 51:1121-9. 2010
  10. ncbi Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)
    S Harder
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Endocrinology 142:1188-94. 2001

Research Grants

  1. INTERACTION OF RGS PROTEINS WITH G BETA SUBUNIT G BETA 5
    Vladlen Slepak; Fiscal Year: 2003
  2. Interaction of RGS Protein with G beta subunit G beta 5
    Vladlen Slepak; Fiscal Year: 2007
  3. Interaction of RGS Protein with G beta subunit G beta 5
    Vladlen Slepak; Fiscal Year: 2007
  4. REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR RESPONSES
    Julie Saugstad; Fiscal Year: 2002
  5. RGS DOMAIN FUNCTION IN MAMMALIAN RETINA
    Theodore Wensel; Fiscal Year: 2005
  6. RGS Protein Function in Mammalian Retina
    Theodore G Wensel; Fiscal Year: 2010
  7. RGS Protein Function in Mammalian Retina
    Theodore Wensel; Fiscal Year: 2007
  8. RGS Domain Function in Mammalian Brain
    Theodore Wensel; Fiscal Year: 2006
  9. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2010
  10. Signaling mechanisms of retinal bipolar cells
    CATHERINE MORGANS; Fiscal Year: 2009

Scientific Experts

  • Javier Garzón
  • O Saitoh
  • Stephen J Gold
  • Brahim Aissani
  • Philip B Wedegaertner
  • CATHERINE MORGANS
  • NANCY MUMA
  • Hank P Jedema
  • Brett G Jeffrey
  • Christa Hohoff
  • D J Pepperl
  • T Ingi
  • SHELLY B HOOKS
  • William F Simonds
  • Seena K Ajit
  • Lisa M Guay-Woodford
  • H Austin
  • N A Alam
  • Vladlen Slepak
  • Theodore Wensel
  • Julie Saugstad
  • Lisa Guay Woodford
  • Kirill A Martemyanov
  • Ching Kang Chen
  • Kendall J Blumer
  • Ching Kang Jason Chen
  • Vladlen Z Slepak
  • Theodore G Wensel
  • Yan Cao
  • Garret R Anderson
  • KENDALL BLUMER
  • Richard Neubig
  • Simone L Sandiford
  • Rebecca A Roof
  • Rakesh K Singh
  • D Scott Witherow
  • Richard R Neubig
  • Dimitra Terzi
  • Ikuo Masuho
  • Hoon Shim
  • Kevin Wickman
  • Qiang Wang
  • Ryan M Drenan
  • Ekaterina Posokhova
  • V Z Slepak
  • Muralidharan Jayaraman
  • Anjali Rao
  • David L Roman
  • Konstantin Levay
  • Ana Fajardo-Serrano
  • Cesare Orlandi
  • Venetia Zachariou
  • Jeffrey L Waugh
  • Rafael Lujan
  • Mark J Thomas
  • Ada M C Ho
  • Jeffery N Talbot
  • Alapakkam P Sampath
  • Keqiang Xie
  • Jianmei Zhang
  • Leelamma M Panicker
  • Frank S Chen
  • R K Singh
  • Deb Kumar Mojumder
  • J L McCauley
  • Alyson C Howlett
  • Yasar Saleem
  • Rebecca Dallman
  • D Grabowska
  • Yuren Wang
  • Khyobeni Mozhui
  • Anuradha Dhingra
  • Maxim Sokolov
  • J L Cabrera
  • Hongman Song
  • Vijaya Narayanan
  • Evan A Yost
  • Yael Chertkow
  • B E Snow
  • Henry I Mosberg
  • Joseph H Song
  • Phullara B Shelat
  • C Thomas G Appleton
  • James E Huettner
  • D S Witherow
  • Kathleen H Young
  • Maurine E Linder
  • Craig A Doupnik
  • Yolande van Bever
  • Almudena López-Fando

Detail Information

Publications97

  1. doi RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11
    Yasar Saleem
    Center for Neural Science, Korea Institute of Science and Technology KIST, P O BOX 131, Cheongryang, Seoul 130 650, Republic of Korea
    Biochem Biophys Res Commun 386:65-70. 2009
    ..However, presence of Gbeta5 reduced the affinity of R7-RGS7 for Galpha subunits, also only RGS7 bound to Muscarinic M3-Receptor, but the Gbeta5-RGS7 dimer did not, making it ..
  2. ncbi Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter
    Javier Garzón
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, E 28002 Madrid, Spain
    Neuropharmacology 48:853-68. 2005
    ..No RGS2, RGS7, RGS10 and RGS11 proteins were associated with the mu receptors in these PAG membranes...
  3. pmc Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family
    Ryan M Drenan
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 169:623-33. 2005
    The RGS7 (R7) family of RGS proteins bound to the divergent Gbeta subunit Gbeta5 is a crucial regulator of G protein-coupled receptor (GPCR) signaling in the visual and nervous systems...
  4. ncbi New dimensions in G protein signalling: G beta 5 and the RGS proteins
    W F Simonds
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pharm Acta Helv 74:333-6. 2000
    ..Recently specific native complexes between G beta 5 and the regulator of G protein signaling (RGS) protein-7 (RGS7) and between G beta 5L (a splice variant with a 42 amino acid N-terminal extension) and RGS9 have been isolated ..
  5. ncbi Enhancement of pheromone response by RGS9 and Gbeta5 in yeast
    Seena K Ajit
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543, USA
    Biochem Biophys Res Commun 324:686-91. 2004
    ..We evaluated GGL containing RGS9 and RGS7 for functional complementation in a RGS (sst2Delta) knockout yeast strain...
  6. pmc Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907
    Rakesh K Singh
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    Int J Neuropsychopharmacol 12:651-65. 2009
    ..desensitization of 5-HT2A receptor-stimulated phospholipase C (PLC) activity is associated with increases in RGS7 protein levels both in vivo and in cells in culture, and the increase in RGS7 is dependent on activation of the JAK-..
  7. pmc Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release
    R K Singh
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    J Psychopharmacol 24:1079-88. 2010
    ..Olanzapine treatment for 7 days significantly increased the levels of the regulator of G protein signaling (RGS7) protein, RGS7 mRNA levels, and activation of JAK2 in rat frontal cortex...
  8. ncbi Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain
    Tatsuya Ingi
    Department of Neurophysiology, Brain Research Institute, Niigata University, 1 Asahi machi, Niigata 951 8585, Japan
    Eur J Neurosci 15:929-36. 2002
    ..we performed a systematic survey of the localization of mRNAs encoding three subtypes of the RGSs (RGS2, RGS4 and RGS7) in developing rat brains by in situ hybridization through postnatal day 2 (P2), P10 and P18 to adult...
  9. pmc RGS7 and -11 complexes accelerate the ON-bipolar cell light response
    Jianmei Zhang
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington, USA
    Invest Ophthalmol Vis Sci 51:1121-9. 2010
    ..The goal of this study was to determine whether RGS7 and/or -11 serve this function in retinal ON-BPCs.
  10. ncbi Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)
    S Harder
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Endocrinology 142:1188-94. 2001
    ..In contrast, other RGS proteins including RGS7, RGS9, and GAIP had no effect on signaling by mTRH-R1 or mTRH-R2 demonstrating the specificity of RGS4 action...
  11. pmc Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling
    Deb Kumar Mojumder
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:7753-65. 2009
    b>RGS7, RGS11, and their binding partner Gbeta5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), where mGluR6 responds to glutamate released from photoreceptor terminals by activation of the RGS7/RGS11 substrate, ..
  12. ncbi Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5
    T Keren-Raifman
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    FEBS Lett 492:20-8. 2001
    Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K(+) channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic effects of RGSs on GIRK regulation...
  13. ncbi Identification of the Gbeta5-RGS7 protein complex in the retina
    J L Cabrera
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Florida 33136, USA
    Biochem Biophys Res Commun 249:898-902. 1998
    ..Analysis of the isolated complex revealed that G beta 5 is tightly associated with RGS7, a member of the superfamily of negative regulators of G protein signaling...
  14. pmc Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Comp Neurol 510:484-96. 2008
    ..transcripts for G(o) interactors: regulators of G-protein signaling (RGS), Ret-RGS1 (a variant of RGS20), RGS16, RGS7, purkinje cell protein 2 (PCP2, also called L7 or GPSM4), synembryn (RIC-8), LGN (GPSM2), RAP1GAP, and Gbeta5; cGMP ..
  15. pmc Novel peptide ligands of RGS4 from a focused one-bead, one-compound library
    Rebecca A Roof
    Department of Pharmacology, University of Michigan, 1301 MSRB III SPC5632, Ann Arbor, MI 48103, USA
    Chem Biol Drug Des 72:111-9. 2008
    ..They selectively inhibit RGS4 but not RGS7, RGS16, and RGS19...
  16. ncbi Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells
    D S Witherow
    Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 275:24872-80. 2000
    ..Here, we examined the behavior of Gbeta(5), RGS7, RGS9, and Galpha in tissue extracts using immunoprecipitation and conventional chromatography...
  17. ncbi Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats
    Oliver N Hausmann
    The Miami Project to Cure Paralysis, Miami, Florida, USA
    Eur J Neurosci 15:602-12. 2002
    ..Thus far, these complexes were found only in neurons, with RGS7 being the most widely distributed in the brain...
  18. ncbi Differentially regulated expression of endogenous RGS4 and RGS7
    Andrejs M Krumins
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 279:2593-9. 2004
    ..Expression of both RGS4 and RGS7 was detected in rat brain tissue and cultured PC12 and AtT-20 cells...
  19. ncbi Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
    ..Here we extend these studies to additional Rgs genes. We demonstrate that the Rgs4, Rgs5, Rgs7, and Rgs10 genes are differentially regulated during chondrogenic differentiation in vitro and in vivo...
  20. ncbi Biochemical purification and functional analysis of complexes between the G-protein subunit Gbeta5 and RGS proteins
    D Scott Witherow
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Methods Enzymol 390:149-62. 2004
    ..According to pulse-chase analysis, Gbeta5 and RGS7 monomers undergo rapid proteolytic degradation in cells, whereas the dimer is stable...
  21. ncbi Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins
    Rebecca A Roof
    Department of Pharmacology, 1150 W Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA
    Chem Biol Drug Des 67:266-74. 2006
    ..for binding with the switch 1 region of Galphai and that peptide 1 shows selectivity for RGS4 and RGS8 versus RGS7. Structure-activity relationships of analogs related to 1 are described that illustrate key features for RGS ..
  22. pmc Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons
    Yan Cao
    Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 109:7905-10. 2012
    ..Here we identify RGS7 and RGS11 as the key GAPs in the mGluR6 pathway of retinal rod ON bipolar cells that set the sensitivity and time ..
  23. ncbi Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine
    Almudena López-Fando
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, CSIC, Madrid, Spain
    Neuropsychopharmacology 30:99-110. 2005
    The R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11), and its binding protein Gbeta5, are found in neural structures of mouse brain...
  24. pmc Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice
    Hoon Shim
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 287:14873-9. 2012
    Two members of the R7 subfamily of regulators of G protein signaling, RGS7 and RGS11, are present at dendritic tips of retinal depolarizing bipolar cells (DBCs)...
  25. doi Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons
    Ana Fajardo-Serrano
    Instituto de Investigación en Discapacidades Neurológicas IDINE, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla La Mancha, Campus Biosanitario, C Almansa 14, 02006, Albacete, Spain
    Hippocampus 23:1231-45. 2013
    ..microscopy techniques to investigate the formation of macromolecular complexes and spatial relationship of Rgs7/Gβ5 complexes and its prototypical signaling partners, the GABAB receptor and Girk channel...
  26. ncbi Clinical report of a pure subtelomeric 1qter deletion in a boy with mental retardation and multiple anomalies adds further evidence for a specific phenotype
    Yolande van Bever
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Med Genet A 135:91-5. 2005
    ..In addition, the breakpoint region was mapped to a 26 kb region within the RGS7 gene. Among the 17 known genes in the candidate region, are zinc-finger genes...
  27. pmc GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
    Cesare Orlandi
    Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA
    J Cell Biol 197:711-9. 2012
    ..We propose that the interaction of RGS proteins with orphan GPCRs promotes signaling selectivity in G protein pathways...
  28. ncbi A key serine for the GTPase-activating protein function of regulator of G protein signaling proteins is not a general target for 14-3-3 interactions
    Richard J Ward
    Molecular Pharmacolofy Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    Mol Pharmacol 68:1821-30. 2005
    ..that are universal, a serine residue at the C terminus of this domain has been described as the binding site in RGS7 for 14-3-3 proteins...
  29. ncbi Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus
    Phullara B Shelat
    Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri Columbia, 65212, USA
    Neurosci Lett 403:157-61. 2006
    ..In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia...
  30. pmc R7BP modulates opiate analgesia and tolerance but not withdrawal
    Dimitra Terzi
    Department of Basic Sciences, University of Crete, Faculty of Medicine, Laboratory of Pharmacology, Heraklion, Crete, Greece
    Neuropsychopharmacology 37:1005-12. 2012
    ..appears to modulate the membrane localization and stability of three proteins that belong to R7 RGS family: RGS6, RGS7, and RGS9-2...
  31. ncbi Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine
    Yael Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC, and Technion Faculty of Medicine, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:1356-62. 2007
    ..The mRNA expression of chemokine receptors, IL8RA and CCR1, and of RGS7 was significantly down-regulated following fluvoxamine augmentation...
  32. pmc Chronic olanzapine activates the Stat3 signal transduction pathway and alters expression of components of the 5-HT2A receptor signaling system in rat frontal cortex
    N A Muma
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Neuropharmacology 53:552-62. 2007
    ..b>RGS7 protein levels increase in both the membrane and cytosolic fractions in rats treated daily with 10mg/kg olanzapine...
  33. pmc Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells
    Catherine W Morgans
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Eur J Neurosci 26:2899-905. 2007
    ..immunofluorescence and co-immunoprecipitation, we have identified complexes of the Galphao-selective RGS proteins RGS7 and RGS11, with their obligate binding partner, Gbeta5, that are localized to the dendritic tips of murine rod and ..
  34. ncbi Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells
    Anjali Rao
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 27:14199-204. 2007
    ..Gbeta5-L, which interact with and stabilize the R7 members of the regulators of G-protein signaling (RGSs): RGS6, RGS7, RGS9, and RGS11...
  35. pmc Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain
    D Grabowska
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuroscience 151:969-82. 2008
    Members of the regulator of G protein signaling 7 (RGS7) (R7) family and Gbeta5 form obligate heterodimers that are expressed predominantly in the nervous system...
  36. doi Identification of peptides that inhibit regulator of G protein signaling 4 function
    Yuren Wang
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543 8000, USA
    Pharmacology 82:97-104. 2008
    ..inhibition of RGS4 and Galpha-interacting protein (GAIP) GAP activities, yet showed no substantial effect on RGS7. Electrophysiological studies in Xenopus oocytes demonstrated that P17 attenuates RGS4 modulation of M(2) ..
  37. pmc Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons
    Hank P Jedema
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Neurosci 27:2433-43. 2008
    ..We observed that the alpha(2)-autoreceptor-evoked inhibition of LC neurons was reduced and that the expression of RGS7 was increased following chronic stress exposure...
  38. pmc The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7
    Simone L Sandiford
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami School of Medicine, 1600 NW 10 Avenue, R 189, Miami, Florida 33136, USA
    Biochemistry 48:2282-9. 2009
    ..Here we show that the Gbeta5-RGS7 complex can inhibit Ca2+ mobilization elicited by muscarinic acetylcholine receptor type 3 (M3R), but not by other ..
  39. pmc The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
    Garret R Anderson
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Cell Biochem Biophys 54:33-46. 2009
    ..Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL ..
  40. doi Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
    ..positional and functional candidate from the functionally interwoven Rgs (regulator of G-protein signaling) family, Rgs7, in the pathogenesis of PD...
  41. pmc Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7
    Simone L Sandiford
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Biochemistry 49:4998-5006. 2010
    The complex of the regulator of G protein signaling (RGS), Gbeta(5)-RGS7, can inhibit signal transduction via the M3 muscarinic acetylcholine receptor (M3R)...
  42. pmc Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics
    Ada M C Ho
    School of Medical Sciences, Griffith University, Gold Coast Campus, Southport, Australia
    Brain Res 1340:1-9. 2010
    ..We used Real Time PCR to measure the expression of two members of the RGS family, RGS4 and RGS7, in the superior frontal gyrus and primary motor cortex from alcoholic and non-alcoholic cases...
  43. doi New gene variants associated with venous thrombosis: a replication study in White and Black Americans
    H Austin
    Emory University, Rollins School of Public Health, Atlanta, GA, USA
    J Thromb Haemost 9:489-95. 2011
    ..We evaluated 10 single-nucleotide polymorphisms (SNPs) identified in three European case-control studies as risk factors for venous thrombosis...
  44. pmc R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells
    Brett G Jeffrey
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Vis Neurosci 27:9-17. 2010
    ..Similar complexes, including RGS7, RGS11, and Gbeta5, are found in retinal ON-bipolar cell dendrites...
  45. pmc Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein
    Leelamma M Panicker
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1752, USA
    J Neurochem 113:1101-12. 2010
    ..We show here mutant RGS7 lacking the N-terminal Disheveled, EGL-10, Pleckstrin homology domain is expressed in transfected cells but, unlike ..
  46. pmc R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine
    Garret R Anderson
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropsychopharmacology 35:1040-50. 2010
    ..knockdown approach, we show that the sensitivity of motor stimulation to cocaine is instead dependent on RGS7, whose complex formation with R7BP is dictated by RGS9-2 expression...
  47. pmc Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent
    Jeffery N Talbot
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    J Neurochem 112:1026-34. 2010
    ..In contrast, the RGS domain of RGS7 had no effect and inhibited the action of RGS8 as a result of weak physical association with Galphai2 and minimal ..
  48. pmc Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors
    Ikuo Masuho
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:21806-13. 2011
    The R7 family of regulators of G protein signaling (RGS) proteins, comprising RGS6, RGS7, RGS9, and RGS11, regulate neuronal G protein signaling pathways...
  49. pmc Association between regulator of G protein signaling 9-2 and body weight
    Jeffrey L Waugh
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 6:e27984. 2011
    ..the weights of rats after virally transduced overexpression of RGS9-2 or the structurally related RGS proteins, RGS7, or RGS11, in the nucleus accumbens (NAc) and observed a reduction in body weight after overexpression of RGS9-2 ..
  50. pmc Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites
    Frank S Chen
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Invest Ophthalmol Vis Sci 51:686-93. 2010
    ..Mutant mouse strains deficient in RGS7 or -11 were characterized, and the SG711 strain which is deficient in both proteins was examined, to learn whether ..
  51. pmc Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis
    J L McCauley
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232 0700, USA
    Genes Immun 10:624-30. 2009
    ..We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility.
  52. pmc Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity
    Alyson C Howlett
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    J Biol Chem 284:16386-99. 2009
    ..The results also show that Gbeta5-RGS7 assembly is dependent on CCT and PhLP1, but the apparent mechanism is different from that of Gbetagamma...
  53. pmc Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits
    Garret R Anderson
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell Biol 29:3033-44. 2009
    ..We found that under normal conditions two equally abundant striatal R7 RGS proteins, RGS9-2 and RGS7, are unequally coupled to the R7BP subunit, which is present in complex predominantly with RGS9-2 rather than with ..
  54. pmc R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling
    Muralidharan Jayaraman
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Pharmacol Sci 30:17-24. 2009
    ..Particularly intriguing are members of the RGS7 (R7) family (RGS6, RGS7, RGS9 and RGS11), which heterodimerize with Gbeta5...
  55. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008
    ..Qrr1d contains a tRNA cluster, and this is a functionally pertinent candidate for the tRNA synthetases. Rgs7 and Fmn2 are other strong candidates in Qrr1d...
  56. pmc Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP
    Yan Cao
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 28:10443-9. 2008
    ..In this study, we establish that another trimeric complex consisting of RGS7, Gbeta5, and R7BP subunits is specifically targeted to the dendritic tips of retinal bipolar cells...
  57. pmc Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
    Keqiang Xie
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Neurosci 13:661-3. 2010
    ..The type 5 G protein beta subunit (Gbeta5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear...
  58. ncbi Live cell analysis of G protein beta5 complex formation, function, and targeting
    Evan A Yost
    Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822 2623, USA
    Mol Pharmacol 72:812-25. 2007
    ..fluorescence complementation in human embryonic kidney 293 cells to compare the abilities of 7 gamma subunits and RGS7 to compete for interaction with beta(5)...
  59. ncbi Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit
    Vijaya Narayanan
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami, Miami, Florida 33136, USA
    Biochemistry 46:6859-70. 2007
    ..GST fusion of the RGS7 DEP domain (GST-R7DEP) binds to both native and recombinant Gbeta5-RGS7, recombinant Gbetagamma complexes, and ..
  60. ncbi Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures
    Stephen J Gold
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurochem 82:828-38. 2002
    ..At 24 h following chronic ECS, RGS7, -8 and -10 mRNA levels were decreased in the granule cell layer, and RGS7 and -8 mRNA levels were decreased in the ..
  61. ncbi Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha
    Thomas Benzing
    Renal Division and Center for Clinical Research, University Hospital Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    J Biol Chem 277:32954-62. 2002
    ..The inhibitory interaction between 14-3-3 and RGS7 requires phosphorylation of serine 434 of RGS7...
  62. ncbi Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells
    Qin Wang
    Department of Pharmacology, The University of Michigan, Ann Arbor 48109 0632, USA
    J Biol Chem 277:24949-58. 2002
    ..In this study, we used synthetic ribozymes targeted to RGS2, RGS3, RGS5, and RGS7 to assess their function...
  63. ncbi EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
    M R Koelle
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 84:115-25. 1996
    ..Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways...
  64. ncbi Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation
    C S Shi
    BCell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:24293-300. 2001
    ..Although RGS6, RGS7, and RGS11 bind Gbeta(5) in the absence of a Ggamma subunit, RGS proteins are not known to directly influence ..
  65. ncbi Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain
    J H Zhang
    Metabolic Diseases Branch and the Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:10284-9. 2001
    ..The subcellular localization of Gbeta(5) and RGS7 was examined in rat PC12 pheochromocytoma cells and mouse brain...
  66. ncbi RGS7 is palmitoylated and exists as biochemically distinct forms
    J J Rose
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Neurochem 75:2103-12. 2000
    ..b>RGS7 and its binding partners Galpha and Gbeta5 are enriched in brain, but biochemical mechanisms governing RGS7/Galpha/..
  67. ncbi Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model
    L M Guay-Woodford
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Am Soc Nephrol 11:1253-60. 2000
    ..Interestingly, the gene encoding RGS7, a regulator of G protein signaling that binds to polycystin-1, was mapped to the same Chr 1 interval...
  68. ncbi 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity
    T Benzing
    Department of Medicine, University Hospital of Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Biol Chem 275:28167-72. 2000
    ..Here we show that 14-3-3 proteins associate with RGS7 and RGS3...
  69. ncbi Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways
    B A Posner
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 274:31087-93. 1999
    ..and GGL (G protein gamma subunit-like) domains form a subfamily that includes the mammalian RGS proteins RGS6, RGS7, RGS9, and RGS11...
  70. pmc Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11
    B E Snow
    Amgen Institute, Toronto, ON, Canada M5G2C1
    Proc Natl Acad Sci U S A 96:6489-94. 1999
    ....
  71. ncbi dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7
    T Elmore
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas 75235 9111, USA
    DNA Cell Biol 17:983-9. 1998
    ..to encode a 428-amino acid protein with >55% overall amino acid sequence identity with the vertebrate protein RGS7 and the C. elegans EGL-10...
  72. pmc A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits
    B E Snow
    Quantitative Biology Laboratory, Amgen Institute, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 95:13307-12. 1998
    ..GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10...
  73. ncbi RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 52:118-24. 1998
    ..Outside of the homology domain, RGS9 shows more extended similarity to human RGS6 and RGS7, rat RGS12, and the C. elegans protein EGL-10...
  74. ncbi Regulation of RGS mRNAs by cAMP in PC12 cells
    D J Pepperl
    Parke Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA
    Biochem Biophys Res Commun 243:52-5. 1998
    ..Using antisense riboprobes selective for rat RGS4, RGS7, and RGS2, we examined the regulation of these RGS mRNAs in PC12 cells in response to agents which elevate ..
  75. ncbi RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity
    Shelley B Hooks
    Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 278:10087-93. 2003
    ..Gbeta(5)/RGS11 were more potent GAPs of Galpha(i1), Galpha(i2), and Galpha(i3) than were Gbeta(5)/RGS6 and Gbeta(5)/RGS7. The maximal GAP activity exhibited by Gbeta(5)/RGS11 was 2- to 4-fold higher than that of Gbeta(5)/RGS7 and Gbeta(..
  76. ncbi Regulation of RGS proteins by chronic morphine in rat locus coeruleus
    Stephen J Gold
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390, USA
    Eur J Neurosci 17:971-80. 2003
    ..In contrast, levels of RGS7 and -11 proteins, the only other subtypes for which antibodies are available, were not altered by these treatments...
  77. ncbi Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain
    S J Gold
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 17:8024-37. 1997
    ..Striking region-specific patterns of expression were observed. Five subtypes, RGS4, RGS7, RGS8, RGS9, and RGS10 mRNAs, are densely expressed in brain, whereas the other subtypes (RGS3, RGS5, RGS6, and ..
  78. ncbi Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina
    Joseph H Song
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E Minneapolis, MN 55455, USA
    Mol Cell Neurosci 35:311-9. 2007
    ..Here we demonstrate that the four R7 RGS proteins: RGS6, RGS7, RGS9 and RGS11 differentially associate with two membrane anchors...
  79. ncbi Olanzapine increases RGS7 protein expression via stimulation of the Janus tyrosine kinase-signal transducer and activator of transcription signaling cascade
    Rakesh K Singh
    Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA
    J Pharmacol Exp Ther 322:133-40. 2007
    ..receptors in both cytosol (234 +/- 34% of control level) and membrane fractions (206 +/- 14% of control levels) and RGS7 proteins in both cytosol (193 +/- 32% of control levels) and membrane fractions (160 +/- 18% of control levels) as ..
  80. ncbi RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling
    Seena K Ajit
    Neuroscience Discovery, Wyeth Research CN 8000, Princeton NJ 08543, USA
    Cell Signal 19:723-30. 2007
    ..the observed interaction because PKCI-1 interacted with N-terminus of RGS17 and GAIP, but not with that of RGS2 or RGS7 where cysteine string motif is absent...
  81. ncbi R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism
    Ryan M Drenan
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:28222-31. 2006
    The RGS7 (R7) family of G protein regulators, Gbeta5, and R7BP form heterotrimeric complexes that potently regulate the kinetics of G protein-coupled receptor signaling...
  82. pmc Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity
    Y M Hajdu-Cronin
    Howard Hughes Medical Institute HHMI and Division of Biology, California Institute of Technology, Pasadena, California 91125 USA
    Genes Dev 13:1780-93. 1999
    ..eat-16 encodes a regulator of G protein signaling (RGS) most similar to the mammalian RGS7 and RGS9 proteins and can inhibit endogenous mammalian G(q)/G(11) in COS-7 cells...
  83. ncbi Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics
    Amy Benians
    BHF Laboratories and Department of Medicine, University College London, Room 420, 4th Floor, 5 University Street, London WC1E 6JJ, United Kingdom
    J Biol Chem 280:13383-94. 2005
    ..transfer microscopy showed a stable physical interaction between the G-protein alpha subunit and RGS (RGS8 and RGS7) that is independent of the functional state of the G-protein...
  84. ncbi Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization
    Javier Garzón
    Department of Neuropharmacology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, E 28002 Madrid, Spain
    J Biol Chem 280:8951-60. 2005
    ..b>RGS7 and RGS11 present in this neural structure showed no association with MOR...
  85. pmc Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o
    Satoshi Takida
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 839 BLSB, Philadelphia, PA 19107, USA
    Mol Pharmacol 67:132-9. 2005
    ..b>RGS7 belongs to a subfamily of RGS proteins that exist as dimers with the G protein beta(5)-subunit...
  86. ncbi Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system
    Christopher Larminie
    Department of Bioinformatics, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, CM19 5AW, UK
    Brain Res Mol Brain Res 122:24-34. 2004
    ..Five RGS members were identified with enriched expression in brain. RGS4, RGS7, RGS8, RGS11 and RGS17 were all significantly expressed in striatal regions including the nucleus accumbens and ..
  87. ncbi G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction
    D Scott Witherow
    Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 278:21307-13. 2003
    ..However, initial studies with purified Gbeta5.RGS6 or Gbeta5.RGS7 showed that they only serve as GTPase activating proteins for Galphao...
  88. pmc Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5
    Ching Kang Chen
    Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City 84112, USA
    Proc Natl Acad Sci U S A 100:6604-9. 2003
    RGS (regulator of G protein signaling) proteins containing the G protein gamma-like (GGL) domain (RGS6, RGS7, RGS9, and RGS11) interact with the fifth member of the G protein beta-subunit family, Gbeta5...
  89. ncbi The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors
    Javier Garzón
    1Neurofarmacología, Instituto de Neurobiologia Santiago Ramon y Cajal, CSIC, Madrid, Spain
    Neuropsychopharmacology 28:1983-90. 2003
    Members of the R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11) are found in the mouse CNS...
  90. ncbi RGS8 expression in developing cerebellar Purkinje cells
    Osamu Saitoh
    Department of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu shi, Tokyo 183 8526, Japan
    Biochem Biophys Res Commun 309:836-42. 2003
    ..We also studied the expression of RGS7, which is expressed in Golgi cells in the granule cell layer of adult cerebellum...
  91. ncbi A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal
    Gonzalo A Carrasco
    Department of Pharmacology, Loyola University of Chicago, Stritch School of Medicine, 2160 South First Ave, Maywood, IL 60153, USA
    J Pharmacol Exp Ther 307:1012-9. 2003
    ..membrane and cytosol-associated 5-HT2A receptors, Galphaq, Galpha11, regulators of G protein signaling (RGS)4, and RGS7 proteins were assayed in the hypothalamic paraventricular nucleus, amygdala, and frontal cortex using Western blot ..
  92. ncbi Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
    N A Alam
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Cancer Genet Cytogenet 147:121-7. 2003
    ..Also of interest is the absence of phenotypic abnormality apart from multiple leiomyomatosis in any deletion carrier even though the adjacent genes RGS7, KMO, CHML, and OPN3 were also deleted.
  93. pmc Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins
    K Levay
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 96:2503-7. 1999
    ..and identified the protein tightly associated with Gbeta5 as the regulator of G protein signaling (RGS) protein, RGS7. Here we show that complexes of Gbeta5 with RGS proteins can be formed in vitro from the recombinant proteins...
  94. ncbi RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents
    O Saitoh
    Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu shi, Tokyo 183 8526, Japan
    J Biol Chem 274:9899-904. 1999
    ..1997) Nature 390, 525-529). Here we report the isolation of a full-length rat cDNA of another brain-specific RGS, RGS7. In situ hybridization study revealed that RGS7 mRNA is predominantly expressed in Golgi cells within granule cell ..
  95. pmc Interaction between RGS7 and polycystin
    E Kim
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:6371-6. 1999
    ..We identified a short-lived RGS protein, RGS7, that is rapidly degraded through the proteasome pathway...
  96. ncbi RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells
    D J Shuey
    Department of CNS Disorders, Wyeth Ayerst Research, Princeton, New Jersey 08543 8000, USA
    J Neurochem 70:1964-72. 1998
    ..Here, we demonstrate that RGS7 is a potent GAP in vitro on G(alpha i1), and G(alpha o) heterotrimeric proteins and that RGS7 acts to down-regulate ..
  97. ncbi Snapin interacts with the N-terminus of regulator of G protein signaling 7
    Rachel A Hunt
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543 8000, USA
    Biochem Biophys Res Commun 303:594-9. 2003
    The N-terminus of regulator of G protein signaling 7 (RGS7) contains a dishevelled/egl-10/pleckstrin (DEP) domain of unknown function...

Research Grants75

  1. INTERACTION OF RGS PROTEINS WITH G BETA SUBUNIT G BETA 5
    Vladlen Slepak; Fiscal Year: 2003
    ..This Ggamma-like domain is present in RGS6, RGS7, RGS9 and EGL-10, an RGS from C. elegans...
  2. Interaction of RGS Protein with G beta subunit G beta 5
    Vladlen Slepak; Fiscal Year: 2007
    ..of RGS proteins, those containing a Gy-like (GGL) domain, interacts with GP5, and this project is focused on GP5-RGS7 complex, which is widely expressed in the brain...
  3. Interaction of RGS Protein with G beta subunit G beta 5
    Vladlen Slepak; Fiscal Year: 2007
    ..of RGS proteins, those containing a Gy-like (GGL) domain, interacts with GB5, and this project is focused on GB5-RGS7 complex, which is widely expressed in the brain...
  4. REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR RESPONSES
    Julie Saugstad; Fiscal Year: 2002
    ..The specific aims are to: (1) determine the effects of RGS7 protein on mGluR responses in heterologous expression systems, (2) determine the effects of RGS proteins on mGluR ..
  5. RGS DOMAIN FUNCTION IN MAMMALIAN RETINA
    Theodore Wensel; Fiscal Year: 2005
    ..4. To determine the roles of RGS11 and RGS7 in vision by characterizing their multiple splice variants, identifying the retinal cells in which they are ..
  6. RGS Protein Function in Mammalian Retina
    Theodore G Wensel; Fiscal Year: 2010
    ..2. The role of RGS7 and its complexes in responses of ON bipolar to mGluR6 activation will be determined using biochemical and ..
  7. RGS Protein Function in Mammalian Retina
    Theodore Wensel; Fiscal Year: 2007
    ..2. The role of RGS7 and its complexes in responses of ON bipolar to mGluR6 activation will be determined using biochemical and ..
  8. RGS Domain Function in Mammalian Brain
    Theodore Wensel; Fiscal Year: 2006
    ..Localization within the striatum of another neuronal RGS protein with similar domain structure to RGS9-1, RGS7, will also be examined...
  9. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2010
    ..of type 3 muscarinic receptor (M3R) by a neurospecific regulator of G protein signaling (RGS), the Gbeta5-RGS7 complex...
  10. Signaling mechanisms of retinal bipolar cells
    CATHERINE MORGANS; Fiscal Year: 2009
    ..We have identified two similar complexes, G5-RGS7 and G5-RGS11, in ON-BPC dendrites suggesting a similar mechanism of deactivation of the ON-BPC signal transduction ..
  11. REGULATION OF G PROTEIN GTPASE IN PHOTORECEPTORS
    Vladlen Slepak; Fiscal Year: 2003
    ..Preliminary data with non-photoreceptor isoforms, RGS7 and Gbeta5, suggest that Gbeta5L can attenuate RGS9 activity...
  12. RECOVERY OF PHOTOTRANSDUCTION
    Ching Kang Chen; Fiscal Year: 2009
    ..2) the deactivation of cone transducin, rather than cone pigments, rate-limits normal cone recovery and 3) Gbeta5/RGS7 and Gbeta5/RGS11 protein complex are functionally redundant at the tips of the ON-type bipolar cell dendrites as ..
  13. RECOVERY OF PHOTOTRANSDUCTION
    Ching Kang Jason Chen; Fiscal Year: 2010
    ..the deactivation of cone transducin, rather than cone pigments, rate-limits normal cone recovery and 3) Gbeta5/RGS7 and Gbeta5/RGS11 protein complex are functionally redundant at the tips of the ON-type bipolar cell dendrites as ..
  14. RECOVERY OF PHOTOTRANSDUCTION
    Ching Kang Chen; Fiscal Year: 2007
    ..2) the deactivation of cone transducin, rather than cone pigments, rate-limits normal cone recovery and 3) Gbeta5/RGS7 and Gbeta5/RGS11 protein complex are functionally redundant at the dendritic tips of the ON-type bipolar cells...
  15. MECHANISM AND REGULATION OF RECEPTOR-G PROTEIN SIGNALING
    Kendall J Blumer; Fiscal Year: 2010
    ..of G25, the most diverged and least understood G2 family member, bound to the G3-like domain of any member of the RGS7 (R7) family of G protein regulators. R7-G25 heterodimers bind R7BP, a novel palmitoylated SNARE-like protein...
  16. MECHANISM AND REGULATION OF RECEPTOR-G PROTEIN SIGNALING
    KENDALL BLUMER; Fiscal Year: 2009
    ..of G25, the most diverged and least understood G2 family member, bound to the G3-like domain of any member of the RGS7 (R7) family of G protein regulators. R7-G25 heterodimers bind R7BP, a novel palmitoylated SNARE-like protein...
  17. MECHANISM AND REGULATION OF RECEPTOR-G PROTEIN SIGNALING
    Kendall J Blumer; Fiscal Year: 2010
    ..of G25, the most diverged and least understood G2 family member, bound to the G3-like domain of any member of the RGS7 (R7) family of G protein regulators. R7-G25 heterodimers bind R7BP, a novel palmitoylated SNARE-like protein...
  18. Mechanisms of 5HT2A Receptor Desensitization
    Nancy A Muma; Fiscal Year: 2010
    ..post- translational modifications to G proteins while chronic treatment with a 5-HT2A receptor antagonist increases RGS7 protein expression via increases in JAK/STAT signaling (STAT being a transcription factor)...
  19. Signaling mechanisms of retinal bipolar cells
    Catherine W Morgans; Fiscal Year: 2010
    ..We have identified two similar complexes, G5-RGS7 and G5-RGS11, in ON-BPC dendrites suggesting a similar mechanism of deactivation of the ON-BPC signal transduction ..
  20. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2010
    ..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
  21. BIOLOGY OF EARLY RENAL CYSTOGENESIS IN THE CPK MOUSE
    Lisa Guay Woodford; Fiscal Year: 2003
    ..As already mentioned a more detailed experimental protocol is required to confirm or refute the speculations. Thus, it would be better to concentrate on the cloning of cpk gene. ..
  22. The role of nyctalopin in the mammalian retina
    CATHERINE MORGANS; Fiscal Year: 2006
    ..These results will provide insight into the role of nyctalopin in synaptic transmission between photoreceptors and ON-BPCs in the retina, and may lead to the identification of other components of the ON-BPC pathway. ..
  23. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip Wedegaertner; Fiscal Year: 2007
    ..abstract_text> ..
  24. SYNERGY BETWEEN SSRIS AND OVARIAN HORMONES
    NANCY MUMA; Fiscal Year: 2003
    ..abstract_text> ..
  25. Membrane Targeting of G Proteins
    Philip Wedegaertner; Fiscal Year: 2009
    ..Thus, it is clear that understanding the mechanisms that regulate GRK localization could lead to novel ways to therapeutically target individual GRKs. ..
  26. Membrane Targeting of G Proteins
    Philip Wedegaertner; Fiscal Year: 2009
    ....
  27. Membrane Targeting of G Proteins
    Philip B Wedegaertner; Fiscal Year: 2010
    ....