RFC1

Summary

Gene Symbol: RFC1
Description: replication factor C subunit 1
Alias: MHCBFB, PO-GA, RECC1, RFC, RFC140, replication factor C subunit 1, A1 140 kDa subunit, DNA-binding protein PO-GA, MHC binding factor, beta, RF-C 140 kDa subunit, activator 1 140 kDa subunit, activator 1 large subunit, activator 1 subunit 1, replication factor C (activator 1) 1, 145kDa, replication factor C 140 kDa subunit, replication factor C large subunit, replication factor C1
Species: human
Products:     RFC1

Top Publications

  1. Shaw G, Zhu H, Lammer E, Yang W, Finnell R. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects. Am J Epidemiol. 2003;158:747-52 pubmed
    ..The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1)...
  2. Pei L, Zhu H, Ren A, Li Z, Hao L, Finnell R, et al. Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population. Birth Defects Res A Clin Mol Teratol. 2005;73:430-3 pubmed
    ..Folate transporter genes, including the reduced folate carrier gene (RFC1), have been proposed as NTD risk factors...
  3. Coppede F, Marini G, Bargagna S, Stuppia L, Minichilli F, Fontana I, et al. Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women. Am J Med Genet A. 2006;140:1083-91 pubmed
    ..The 80G>A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the ..
  4. Scala I, Granese B, Sellitto M, Salomè S, Sammartino A, Pepe A, et al. Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring. Genet Med. 2006;8:409-16 pubmed
    ..46; 95% CI 1.02-2.10), the MTHFR 1298CC genotype (OR 2.29; 95% CI 1.06-4.96), the reduced-folate-carrier1 (RFC1) 80G allele (1.48; 95% CI 1.05-2.10) and the RFC1 80 GG genotype (OR 2.05; 95% CI 1.03-4.07)...
  5. Biselli J, Goloni Bertollo E, Zampieri B, Haddad R, Eberlin M, Pavarino Bertelli E. Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil. Genet Mol Res. 2008;7:33-42 pubmed
    ..reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS)...
  6. Shaw G, Lammer E, Zhu H, Baker M, Neri E, Finnell R. Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. Am J Med Genet. 2002;108:1-6 pubmed
    ..We focused our studies on a candidate gene that is involved in folate transport, the reduced folate carrier 1 (RFC1)...
  7. De Marco P, Calevo M, Moroni A, Merello E, Raso A, Finnell R, et al. Reduced folate carrier polymorphism (80A-->G) and neural tube defects. Eur J Hum Genet. 2003;11:245-52 pubmed
    Transport of folates in mammalian cells occurs by a carrier-mediated mechanism. The human folate carrier (RFC-1) gene has been isolated and characterized...
  8. Pei L, Zhu H, Zhu J, Ren A, Finnell R, Li Z. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China. Ann Epidemiol. 2006;16:352-6 pubmed
    ..risks of congenital heart defects (CHD) and orofacial defects were influenced by a polymorphism of the offspring's RFC1 or by an interaction between the RFC1 gene and maternal periconceptional use of folic acid...
  9. Chango A, Fillon Emery N, Mircher C, Blehaut H, Lambert D, Herbeth B, et al. No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers. Br J Nutr. 2005;94:166-9 pubmed
    ..synthase (MTR) 2756A > G, the cystathionine beta-synthase (CBS) 844Ins68 and the reduced folate carrier (RFC-1) 80G > A polymorphisms, contribute to the risk of trisomy 21...

More Information

Publications123 found, 100 shown here

  1. Biselli J, Brumati D, Frigeri V, Zampieri B, Goloni Bertollo E, Pavarino Bertelli E. A80G polymorphism of reduced folate carrier 1 (RFC1) and C776G polymorphism of transcobalamin 2 (TC2) genes in Down's syndrome etiology. Sao Paulo Med J. 2008;126:329-32 pubmed
    ..This study therefore had the objective of investigating the A80G polymorphism of the reduced folate carrier 1 (RFC1) gene and the C776G polymorphism of the transcobalamin 2 (TC2) gene as maternal risk factors for DS among Brazilian ..
  2. Fintelman Rodrigues N, Correa J, Santos J, Pimentel M, Santos Rebouças C. Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome. Dis Markers. 2009;26:155-61 pubmed publisher
    ..We compared the frequency of CBS 844ins68, MTR 2756A>G, RFC-1 80G&gt A and TC 776C>G polymorphisms among 114 case mothers and 110 matched controls, in order to observe ..
  3. Liao Y, Bao M, Liu C, Liu H, Zhang D. [Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]. Yi Chuan. 2010;32:461-6 pubmed
    ..in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), reduced folate carrier1 (RFC-1), methionine synthase (MTR) involved in folate metabolism and the risk of offsprings of young Chinese women with ..
  4. Brandalize A, Bandinelli E, dos Santos P, Schuler Faccini L. Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil. Dis Markers. 2010;29:95-101 pubmed publisher
    ..of maternal polymorphisms, as well as their risk genotypes combinations of MTR A2756G, MTRR A66G, CBS 844ins68, and RFC A80G, involved in folate/homocysteine metabolism, as possible risk factors for Down syndrome (DS) in Southern ..
  5. Rahman I, Ijaz F, Iqbal Z, Afzal A, Ali N, Afzal M, et al. A novel survey of the ethno medicinal knowledge of dental problems in Manoor Valley (Northern Himalaya), Pakistan. J Ethnopharmacol. 2016;194:877-894 pubmed publisher
    ..94), Rumex dentatus (0.89) and Indigofera heterantha (0.88). Based on the RFC values, the most valuable and cited medicinal plant species used by the traditional drivers are Juglans regia ..
  6. Rashid S, Ahmad M, Zafar M, Sultana S, Ayub M, Khan M, et al. Ethnobotanical survey of medicinally important shrubs and trees of Himalayan region of Azad Jammu and Kashmir, Pakistan. J Ethnopharmacol. 2015;166:340-51 pubmed publisher
    ..indices of informant consensus factor (ICF), fidelity level (FL), use value (UV) and relative frequency citation (RFC)...
  7. Rahman I, Ijaz F, Afzal A, Iqbal Z, Ali N, Khan S. Contributions to the phytotherapies of digestive disorders: Traditional knowledge and cultural drivers of Manoor Valley, Northern Pakistan. J Ethnopharmacol. 2016;192:30-52 pubmed publisher
    ..90) and Trifolium repens (UVi=0.84). Based on the RFC values, the most cited medicinal plant species by the traditional drivers were Ficus carica (0...
  8. Mirgal D, Ghosh K, Mahanta J, Dutta P, Shetty S. Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India. Trans R Soc Trop Med Hyg. 2016;110:294-8 pubmed publisher
    ..MTRR A2756G, SHMT C1420T, GCPII C1561T, MTRR A2756G and GNMT C1289T and RFC1 G80A polymorphisms showed significantly different prevalence between different groups analyzed...
  9. Izci Ay O, Ay M, Erdal M, Cayan F, Tekin S, Soylemez F, et al. Folate metabolism gene polymorphisms and risk for down syndrome offspring in Turkish women. Genet Test Mol Biomarkers. 2015;19:191-7 pubmed publisher
    ..A66G (rs1801394), methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A (rs2236225), reduced folate carrier (RFC1) A80G (rs1051266), and cystathionine β-synthase (CBS) 844ins68...
  10. Luo L, Chen Y, Wang L, Zhuo G, Qiu C, Tu Q, et al. Polymorphisms of Genes Involved in the Folate Metabolic Pathway Impact the Occurrence of Unexplained Recurrent Pregnancy Loss. Reprod Sci. 2015;22:845-51 pubmed publisher
    ..methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL...
  11. Semmler A, Heese P, Stoffel Wagner B, Muschler M, Heberlein A, Bigler L, et al. Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). Alcohol. 2015;49:97-101 pubmed publisher
    ..1298A > C, methyltetrahydrofolate-transferase (MTR) c.2756A > G, reduced folate carrier 1 (RFC1) c.80G > A, and transcobalamin 2 c.776C > G...
  12. Panda D, Fernandez D, Lal M, Buehler E, Moss B. Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants. Proc Natl Acad Sci U S A. 2017;114:3720-3725 pubmed publisher
    ..The siRNAs to RFC1, RFC2, RFC4, and RFC5 mRNAs also enhanced spread of the mutant virus, strengthening the biological significance of ..
  13. Meredith M, MacNeil A, Trasler J, Baltz J. Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size. Biol Reprod. 2016;94:125 pubmed publisher
    ..The folate receptors FOLR1 and FOLR2 as well as reduced folate carrier 1 (RFC1, SLC19A1 protein) each appeared to be present in follicular cells including granulosa cells...
  14. Iyamah P, Idu M. Ethnomedicinal survey of plants used in the treatment of malaria in Southern Nigeria. J Ethnopharmacol. 2015;173:287-302 pubmed publisher
    ..plants identified during the survey, Azadirachta indica was the species of highest relative frequency of citation (RFC - 1.0). The dominant plant parts used in the preparation of remedies were leaves (50...
  15. Kim Y, Moon J, Oh D, Chon J, Song B, Lim J, et al. Genotypic characterization of ESBL-producing E. coli from imported meat in South Korea. Food Res Int. 2018;107:158-164 pubmed publisher
    ..coli ST117 isolates, from an avian pathogenic lineage producing CTX-M-94, harbored fimH, fyuA, iutA, papC, rfc, and traT virulence genes and were not susceptible to quinolones...
  16. Hansen M, Greibe E, Skovbjerg S, Rohde S, Kristensen A, Jensen T, et al. Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha. Cell Signal. 2015;27:1356-68 pubmed publisher
    ..Folates are B vitamins that, when taken up by cells through the Reduced Folate Carrier (RFC), are essential for normal cell growth and replication...
  17. Vijayakumar S, Morvin Yabesh J, Prabhu S, Manikandan R, Muralidharan B. Quantitative ethnomedicinal study of plants used in the Nelliyampathy hills of Kerala, India. J Ethnopharmacol. 2015;161:238-54 pubmed publisher
    ..Ethnomedicinal data was analyzed using frequency citation (FC), relative frequency of citation (RFC) and use value (UV) along with a Pearson correlation coefficient (PCC)...
  18. Suh M, Thompson C, Brorby G, Mittal L, Proctor D. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharmacol. 2016;79:74-82 pubmed publisher
    ..25 mg/m(3)) preclude derivation of a reference concentration (RfC) protective of cancer. Several analyses resulted in an IUR of 0...
  19. Thakur S, Rahat B, Hamid A, Najar R, Kaur J. Identification of regulatory mechanisms of intestinal folate transport in condition of folate deficiency. J Nutr Biochem. 2015;26:1084-94 pubmed publisher
    ..proton coupled folate transporter (PCFT) and reduced folate carrier (RFC), which express at the membrane surfaces...
  20. Nunes C, Silva C, Correia Branco A, Martel F. Lack of effect of the procarcinogenic 17β-estradiol on nutrient uptake by the MCF-7 breast cancer cell line. Biomed Pharmacother. 2017;90:287-294 pubmed publisher
    ..Finally, 3H-folic acid uptake was also not affected by E2, both in the absence and presence of the RFC1 inhibitor, methotrexate...
  21. Yoshida T, Okamoto T, Yano T, Takada K, Kohno M, Suda K, et al. Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer. Anticancer Res. 2016;36:6319-6326 pubmed
    ..glutamyl hydrase (GGH) and folylpolyglutamate synthase] and an Alimta® transporter [reduce folate carrier (RFC)] were measured and examined for potential correlations to chemosensitivity...
  22. Zhang Y, Xu H, Chen H, Wang F, Huai H. Diversity of wetland plants used traditionally in China: a literature review. J Ethnobiol Ethnomed. 2014;10:72 pubmed publisher
    ..Three different ways of assigning an importance value to species (Relative Frequency of Citation RFC; Cultural Importance CI; Cultural Value Index CV) all gave similar results...
  23. Zahoor M, Yousaf Z, Aqsa T, Haroon M, Saleh N, Aftab A, et al. An ethnopharmacological evaluation of Navapind and Shahpur Virkanin district Sheikupura, Pakistan for their herbal medicines. J Ethnobiol Ethnomed. 2017;13:27 pubmed publisher
    ..quantitative indices such as Informant Consent Factor (ICF), Use value (UV), Relative Frequency of Citation (RFC), the Fidelity level (FL) and Jaccard Index (JI). Almost 96 plants belonging to 34 families were reported...
  24. Sargın S, Selvi S, Büyükcengiz M. Ethnomedicinal plants of Aydıncık District of Mersin, Turkey. J Ethnopharmacol. 2015;174:200-16 pubmed publisher
    ..In addition, the relative frequency citation (RFC), use values (UV), informant consensus factor (ICF) and fidelity level (FL) were computed...
  25. Shkedy D, Singh N, Shemesh K, Amir A, Geiger T, Liefshitz B, et al. Regulation of Elg1 activity by phosphorylation. Cell Cycle. 2015;14:3689-97 pubmed publisher
    ..Elg1 encodes a protein that forms an RFC-like complex that unloads the replicative clamp, PCNA, from DNA, mainly in its SUMOylated form...
  26. Fodinger M, Dierkes J, Skoupy S, Röhrer C, Hagen W, Puttinger H, et al. Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients. J Am Soc Nephrol. 2003;14:1314-9 pubmed
    ..This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and ..
  27. Pei L, Ren A, Zhu H, Hao L, Zhao W, Li Z, et al. [Study on reduced folate carrier gene (RFC1) polymorphism in the southern and northern Chinese population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25:499-502 pubmed
    To describe the distribution of reduced folate carrier gene (RFC1)genotype and allele frequency between southern and northern, female and male Chinese population...
  28. Chandran V, Siannis F, Rahman P, Pellett F, Farewell V, Gladman D. Folate pathway enzyme gene polymorphisms and the efficacy and toxicity of methotrexate in psoriatic arthritis. J Rheumatol. 2010;37:1508-12 pubmed publisher
    ..677C>T (rs1801133), MTHFR 1298A>C (rs1801131), DHFR -473T>C (rs1650697), DHFR 35289A>G (rs1232027), and RFC 80G>A (rs1051266)...
  29. García Rodríguez L, De Piccoli G, Marchesi V, Jones R, Edmondson R, Labib K. A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1. Nucleic Acids Res. 2015;43:8830-8 pubmed publisher
    ..Work with budding yeast showed that the 'alternative clamp loader' known as Ctf18-RFC acts by an unknown mechanism to activate the checkpoint kinase Rad53, which then mediates much of the checkpoint ..
  30. Wilson M, Hou Z, Yang S, Polin L, Kushner J, White K, et al. Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Mol Pharmacol. 2016;89:425-34 pubmed publisher
    ..PMX is transported by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT)...
  31. Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, et al. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Res. 2017;45:3189-3203 pubmed publisher
    ..The loading of the clamp onto DNA is performed by the Replication Factor C (RFC) complex, whereas its unloading can be carried out by an RFC-like complex containing Elg1...
  32. Farkas S, Befekadu R, Hahn Strömberg V, Nilsson T. DNA methylation and expression of the folate transporter genes in colorectal cancer. Tumour Biol. 2015;36:5581-90 pubmed publisher
    ..This study aims to explore the DNA methylation pattern of the folate transporter genes FOLR1, PCFT, and RFC1 as well as the corresponding protein expressions in colorectal cancer (CRC) tissue and adjacent non-cancerous ..
  33. Yaseen G, Ahmad M, Zafar M, Sultana S, Kayani S, Cetto A, et al. Traditional management of diabetes in Pakistan: Ethnobotanical investigation from Traditional Health Practitioners. J Ethnopharmacol. 2015;174:91-117 pubmed publisher
    ..Quantitative indices, including Relative Frequency of Citation percentage (RFC %) and Disease Consensus Index (DCI) were calculated...
  34. Shen H, Xu J, Zhao S, Shi H, Yao S, Jiang N. ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation. Int J Clin Exp Pathol. 2015;8:8968-75 pubmed
    Ovarian carcinoma is one of the most common and lethal malignancies in the world. Replication factor C (RFC) plays an important role in DNA replication, DNA damage repair, and checkpoint control during cell cycle progression in all ..
  35. Ouelbani R, Bensari S, Mouas T, Khelifi D. Ethnobotanical investigations on plants used in folk medicine in the regions of Constantine and Mila (North-East of Algeria). J Ethnopharmacol. 2016;194:196-218 pubmed publisher
    ..indices, namely, informant consensus factor, fidelity level (FL), use value (UV), and relative frequency citation (RFC), to evaluate the reliability and richness of herbal knowledge in the region...
  36. Kupiec M. Alternative clamp loaders/unloaders. FEMS Yeast Res. 2016;16: pubmed
    ..Replication factor C (RFC) is the canonical complex in charge of loading PCNA, the replication clamp, during S-phase...
  37. Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, et al. LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line. Mol Pharm. 2017;14:605-613 pubmed publisher
    ..MPR7, OAT2 and RFC1 were detected in the hfRPE cells, but their expression levels were below the limit of quantification in ARPE19 ..
  38. Wade B, Liu H, Samora C, Uhlmann F, Singleton M. Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1. EMBO Rep. 2017;18:558-568 pubmed publisher
    ..The RFCCtf18 variant complex is required for activation of the intra-S-phase checkpoint at stalled ..
  39. Winkelmayer W, Eberle C, Sunder Plassmann G, Fodinger M. Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int. 2003;63:2280-5 pubmed
    The effect of the glutamate carboxypeptidase II GCP2 1561C>T and the reduced folate carrier 1 RFC1 80G>A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown...
  40. Shang Y, Zhao H, Niu B, Li W, Zhou R, Zhang T, et al. Correlation of polymorphism of MTHFRs and RFC-1 genes with neural tube defects in China. Birth Defects Res A Clin Mol Teratol. 2008;82:3-7 pubmed
    ..The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs...
  41. Mejía Ramírez E, Limbo O, Langerak P, Russell P. Critical Function of γH2A in S-Phase. PLoS Genet. 2015;11:e1005517 pubmed publisher
    ..genetic screen in fission yeast reveals that γH2A is critical when there are defects in Replication Factor C (RFC), which loads proliferating cell nuclear antigen (PCNA) clamp onto duplex DNA...
  42. Wu M, Lin Z, Li X, Xin X, An J, Zheng Q, et al. HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2. Sci Rep. 2016;6:36045 pubmed publisher
    ..Ultimately, the interaction between RFC and PCNA or between CDK2 and CyclinE, the telomerase activity and the microsatellite instability (MSI) are ..
  43. Sansanelli S, Ferri M, Salinitro M, Tassoni A. Ethnobotanical survey of wild food plants traditionally collected and consumed in the Middle Agri Valley (Basilicata region, southern Italy). J Ethnobiol Ethnomed. 2017;13:50 pubmed publisher
    ..preparation and, when present, the medicinal use, were recorded and the relative frequency of citation index (RFC) was determined...
  44. Shah K, Raghavan S, Hou Z, Matherly L, Gangjee A. Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores). J Mol Graph Model. 2018;81:125-133 pubmed publisher
    ..cells via the proton-coupled folate transporter (PCFT) over the ubiquitously expressed reduced folate carrier (RFC)...
  45. Smith R, Nasheuer H. Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. FEBS Lett. 2002;527:143-6 pubmed
    ..Furthermore, we demonstrate that exchanging these residues to those of mouse origin can only partially rescue the SV40 DNA replication activity of DNA polymerase alpha-primase. ..
  46. Peng Z, Liao Z, Dziegielewska B, Matsumoto Y, Thomas S, Wan Y, et al. Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair. J Biol Chem. 2012;287:36711-9 pubmed publisher
    ..and completes excision repair via interactions with proliferating cell nuclear antigen and replication factor C (RFC). Unlike proliferating cell nuclear antigen, the interaction with RFC is regulated by hLigI phosphorylation...
  47. Ahmad Najar R, Rahat B, Hussain A, Thakur S, Kaur J, Kaur J, et al. Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. Mol Nutr Food Res. 2016;60:1501-13 pubmed publisher
    ..with decreased uptake of folate, further associated with decreased expression levels of reduced folate carrier (RFC) and increased expression levels of folate exporter (ABCG2) at both mRNA and protein levels, which in turn ..
  48. Shiomi Y, Nishitani H. Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication. Genes (Basel). 2017;8: pubmed publisher
    ..PCNA is loaded onto chromatin by PCNA-loading replication factor C (RFC) complexes. Both RFC1-RFC and Ctf18-RFC fundamentally function as PCNA loaders...
  49. Kwon Y, Daley J, Sung P. Reconstituted System for the Examination of Repair DNA Synthesis in Homologous Recombination. Methods Enzymol. 2017;591:307-325 pubmed publisher
    ..synthesis reactions using purified Saccharomyces cerevisiae HR (Rad51, RPA, and Rad54) and DNA replication (PCNA, RFC, and DNA polymerase δ) proteins and document the role of the Pif1 helicase in DNA synthesis via a migrating DNA ..
  50. Peterson L, Rusticus S, Eva K, Wilson D, Pittini R, Schreiber M, et al. Using the Readiness for Clerkship and Residency Surveys to Evaluate the Effectiveness of Four MD Programs: A Cross-Institutional Generalizability Study. Acad Med. 2017;92:S100-S109 pubmed publisher
    ..The "Readiness for Clerkship" (RfC) and "Readiness for Residency" (RfR) surveys have been shown to provide reliable ratings of the relative ..
  51. Montalvão de Azevedo R, Vasconcelos G, Vargas F, Thuler L, Pombo de Oliveira M, de Camargo B. RFC-1 80G>A polymorphism in case-mother/control-mother dyads is associated with risk of nephroblastoma and neuroblastoma. Genet Test Mol Biomarkers. 2015;19:75-81 pubmed publisher
    ..The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma...
  52. Dean J, Wong K, Welsh L, Jones A, Schick U, Newbold K, et al. Normal tissue complication probability (NTCP) modelling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting from head and neck radiotherapy. Radiother Oncol. 2016;120:21-7 pubmed publisher
    ..Penalised logistic regression, support vector classification and random forest classification (RFC) models were generated and compared...
  53. Krychman M, Rowan C, Allan B, Derogatis L, Durbin S, Yacoubian A, et al. Effect of Single-Treatment, Surface-Cooled Radiofrequency Therapy on Vaginal Laxity and Female Sexual Function: The VIVEVE I Randomized Controlled Trial. J Sex Med. 2017;14:215-225 pubmed publisher
    ..To evaluate the efficacy and safety of surface-cooled, monopolar radiofrequency (RFc) therapy for the treatment of vaginal laxity in the VIVEVE I trial...
  54. Fujisawa R, Ohashi E, Hirota K, Tsurimoto T. Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ? efficiently loads the PCNA sliding clamp. Nucleic Acids Res. 2017;45:4550-4563 pubmed publisher
    The alternative proliferating-cell nuclear antigen (PCNA)-loader CTF18-RFC forms a stable complex with DNA polymerase ? (Pol?)...
  55. Grabarczyk D, Silkenat S, Kisker C. Structural Basis for the Recruitment of Ctf18-RFC to the Replisome. Structure. 2018;26:137-144.e3 pubmed publisher
    Ctf18-RFC is an alternative PCNA loader which plays important but poorly understood roles in multiple DNA replication-associated processes...
  56. Pellegrini L. Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase. Structure. 2018;26:1-2 pubmed publisher
    Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al...
  57. Skibola C, Forrest M, Coppede F, Agana L, Hubbard A, Smith M, et al. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood. 2004;104:2155-62 pubmed
    ..reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the largest and most comprehensive to date to ..
  58. Lenz B, Soehngen C, Linnebank M, Heberlein A, Frieling H, Kornhuber J, et al. Genetic polymorphisms relevant for one-carbon metabolism show no effect on homocysteine plasma levels and DNA methylation in alcoholism. Psychiatr Genet. 2009;19:215-6 pubmed publisher
  59. Sargın S, Selvi S, López V. Ethnomedicinal plants of Sarigöl district (Manisa), Turkey. J Ethnopharmacol. 2015;171:64-84 pubmed publisher
    ..The relative frequency citation (RFC), use value (UV), informant consensus factor (ICF) and fidelity level (FL) were computed for the plants included in ..
  60. Matur E, Eraslan E, Akyazi I, Ergul Ekiz E, Eseceli H, Keten M, et al. The effect of furnished cages on the immune response of laying hens under social stress. Poult Sci. 2015;94:2853-62 pubmed publisher
    ..The chickens were divided into 2 groups; one of the groups was reared in furnished cages (RFC) and the other was reared in conventional cages (RCC). In wk 17, social stress was applied...
  61. Dai H, Jing S, Wang H, Ma Y, Li L, Song W, et al. VOC characteristics and inhalation health risks in newly renovated residences in Shanghai, China. Sci Total Environ. 2017;577:73-83 pubmed publisher
    ..exposure of 17 health-related VOCs were estimated by the Inhalation Unit Risk (IUR) and Reference Concentration (RfC) proposed by US EPA...
  62. Saha T, Chatterjee M, Verma D, Ray A, Sinha S, Rajamma U, et al. Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems. Prog Neuropsychopharmacol Biol Psychiatry. 2018;84:1-10 pubmed publisher
    ..Stratified analysis showed significantly higher frequency of RFC1 rs1051266 and BHMT rs3733890 "AG" genotypes in full term and prematurely delivered ADHD probands respectively...
  63. Liu T, Singh R, Rios Z, Bhushan A, Li M, Sheridan P, et al. Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells. Cancer Lett. 2015;357:231-41 pubmed publisher
    ..MTX resistance in L1210 cells, we first showed that HSC70 colocalizes and interacts with reduced folate carrier (RFC) in L1210 cells by confocal laser scanning microscopy and Duolink in situ proximity ligation assay...
  64. Bowen N, Kolodner R. Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins. Proc Natl Acad Sci U S A. 2017;114:3607-3612 pubmed publisher
    ..cerevisiae proteins. A mixture of Msh2-Msh6 (or Msh2-Msh3), Exo1, RPA, RFC-Δ1N, PCNA, and Pol ε was found to catalyze both short-patch and long-patch 5' nick-directed MMR of a ..
  65. Reissmann B, Budelmann T, Wissner E, Schlüter M, Heeger C, Mathew S, et al. Five-year clinical outcomes of visually guided laser balloon pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation. Clin Res Cardiol. 2018;107:405-412 pubmed publisher
    ..Short- and midterm clinical outcomes are in accordance with results of radiofrequency current (RFC) ablation for the treatment of paroxysmal atrial fibrillation (PAF)...
  66. Anderson L, Perkins N. Regulation of RelA (p65) function by the large subunit of replication factor C. Mol Cell Biol. 2003;23:721-32 pubmed
    ..We have discovered that the large subunit, p140, of replication factor C (RFC) can function as a regulator of RelA...
  67. Hiraoka M, Kato K, Saito Y, Yasuda K, Kagawa Y. Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women. Biochem Biophys Res Commun. 2004;316:1210-6 pubmed
    ..3%, 1.3%, 18.6%, and 5.3% for methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC-1) A80G, and methionine synthase (MS) A2756G, respectively. The tHcy value was significantly lower (p < 0...
  68. Kobayashi M, Siegal G. 1H, 15N and 13C resonance assignments of the BRCT region of the large subunit of human Replication Factor C. J Biomol NMR. 2005;31:183-4 pubmed
  69. Mostowska A, Hozyasz K, Jagodzinski P. Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population. Clin Genet. 2006;69:512-7 pubmed
    ..cyclohydrolase and 10-formyltetrahydrofolate synthetase (MTHFD1) and reduced folate carrier 1 (RFC1). We observed that there were no statistical differences in allele and genotype frequencies of MTHFR c...
  70. de Lau L, van Meurs J, Uitterlinden A, Smith A, Refsum H, Johnston C, et al. Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiol Aging. 2010;31:2020-2 pubmed publisher
    ..association of seven polymorphisms of genes involved in homocysteine metabolism (MTHFR 677C>T, MTHFR 1298A>C, RFC 80G>A, TC 776C>G, MTR 2756A>G, MTRR 66A>G, and CBS 844ins68) with plasma total homocysteine, cognitive ..
  71. Relton C, Wilding C, Pearce M, Laffling A, Jonas P, Lynch S, et al. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. J Med Genet. 2004;41:256-60 pubmed
    ..MTHFR 677C-->T, MTHFR 1298A-->C, MTRR 66A-->G, SHMT 1420C-->T, CbetaS 844ins68, GCPII 1561C-->T, RFC-1 80G-->A)...
  72. Pei L, Zhu H, Li Z, Zhang W, Ren A, Zhu J, et al. Interaction between maternal periconceptional supplementation of folic acid and reduced folate carrier gene polymorphism of neural tube defects. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:284-7 pubmed
    To search the interaction between reduced folate carrier gene (RFC1 A80G) polymorphism of children with neural tube defects (NTDs) and maternal periconceptional no supplementation of folic acid...
  73. Curtin K, Slattery M, Ulrich C, Bigler J, Levin T, Wolff R, et al. Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis. 2007;28:1672-9 pubmed
    ..MTHFR), thymidylate synthase (TS), transcobalamin II (TCNII), methionine synthase (MTR), reduced folate carrier (RFC), methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), dihydrofolate reductase (DHFR) and alcohol dehydrogenase 3 (..
  74. Dervieux T, Furst D, Lein D, Capps R, Smith K, Caldwell J, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis. 2005;64:1180-5 pubmed
    ..A composite pharmacogenetic index comprising low penetrance genetic polymorphisms in reduced folate carrier (RFC-1 G80A), AICAR transformylase (ATIC C347G), and thymidylate synthase (TSER*2/*3) was calculated...
  75. Vijayakrishnan J, Houlston R. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Haematologica. 2010;95:1405-14 pubmed publisher
    ..16; 95%ci: 1.04-1.30), mtrr a66g (or=0.73, 95%ci:0.59-0.91), shmt1 c1420t (or=0.79, 95%ci: 0.65-0.98), rfc1 g80a (or=1.37, 95%ci: 1.11-1.69), cyp1a1*2a (or=1.36, 95%ci:1.11-1.66), cyp2e1*5b (or=1.99, 95%ci:1.32-3...
  76. Ubeda M, Habener J. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. J Biol Chem. 1997;272:19562-8 pubmed
    ..Recent in vitro mutagenesis support this proposal (Uhlmann, F., Cai, J., Gibbs, E., O'Donnel, M., and Hurwitz, J. (1997) J. Biol. Chem. 272, 10058-10064). ..
  77. Neish A, Anderson S, Schlegel B, Wei W, Parvin J. Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res. 1998;26:847-53 pubmed
    ..of the holoenzyme complex, most notably the proteins which function in repair of damaged DNA, such as PCNA, RFC and RPA...
  78. Rajgopal A, Sierra E, Zhao R, Goldman I. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Am J Physiol Cell Physiol. 2001;281:C1579-86 pubmed
    ..with intestinal epithelial cells have suggested that this activity is mediated by the reduced folate carrier (RFC1)...
  79. Götze T, Rocken C, Röhl F, Wex T, Hoffmann J, Westphal S, et al. Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett. 2007;251:228-36 pubmed
    ..we analyzed this polymorphism, the glutamate carboxypeptidase (GCP) II C1561T and the reduced folate carrier (RFC) G80A in a case-control study involving 106 patients with histologically confirmed and characterized gastric cancer ..
  80. Galbiatti A, Ruiz M, Rezende Pinto D, Raposo L, Maniglia J, Pavarino Bertelli E, et al. A80G polymorphism of reduced folate carrier 1 (RFC1) gene and head and neck squamous cell carcinoma etiology in Brazilian population. Mol Biol Rep. 2011;38:1071-8 pubmed publisher
    ..We observed association between the RFC1 A80G polymorphism and the risk of this disease...
  81. Girardi A, Martinelli M, Cura F, Palmieri A, Carinci F, Sesenna E, et al. RFC1 and non-syndromic cleft lip with or without cleft palate: an association based study in Italy. J Craniomaxillofac Surg. 2014;42:1503-5 pubmed publisher
    ..We performed a family based association study in order to assess if a genetic variant of RFC1 could be involved in NSCL/P onset...
  82. Haney J, McCant D, Honeycutt M, Lange S. Development of an inhalation reference concentration for diethanolamine. Regul Toxicol Pharmacol. 2018;92:55-66 pubmed publisher
    An inhalation reference concentration (RfC) was developed for diethanolamine (DEA), based principally on evaluation of three animal studies (Gamer et al., 1993, 1996, 2008)...
  83. James S, Melnyk S, Jernigan S, Pavliv O, Trusty T, Lehman S, et al. A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1209-20 pubmed publisher
    ..In case-control analysis, a significant increase in the reduced folate carrier (RFC1) G allele frequency was found among case mothers, but not among fathers or affected children...
  84. Han J, Liu T, Huen M, Hu L, Chen Z, Huang J. SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 2014;205:811-27 pubmed publisher
    ..Collectively, our results provide evidence that the RAD18 E3 ligase requires an accessory protein for binding to its substrate PCNA. ..
  85. Shi M, Caprau D, Romitti P, Christensen K, Murray J. Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2. Birth Defects Res A Clin Mol Teratol. 2003;67:545-9 pubmed
    ..Six polymorphisms in five folate metabolism-related genes (MTHFR, MTHFD, MTRR, GCP2, and RFC1) were genotyped on a collection of 1064 DNA samples from populations around the world, which were made available by ..
  86. Bi X, Zhao H, Zhang Z, Zhang J. Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease. Neurobiol Aging. 2009;30:1601-7 pubmed publisher
    We examined polymorphisms in reduced folate carrier gene (RFC1) and methylenetetrahydrofolate reductase gene (MTHFR) for association with sporadic AD (SAD) in Chinese population...
  87. Morin I, Devlin A, Leclerc D, Sabbaghian N, Halsted C, Finnell R, et al. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab. 2003;79:197-200 pubmed
    ..mutation in glutamate carboxypeptidase II (GCPII) and the 80A-->G (H27R) change in the reduced folate carrier RFC-1...
  88. Pei L, Li Z, Ren A, Zhang W, Zhu H, Zhu J, et al. [A parental case control study on the association between reduced folate carrier gene polymorphism and neural tube defects]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:665-8 pubmed
    To study the association between reduced folate carrier gene (RFC1 A80G) polymorphism and the risk for child with neural tube defects (NTDs), and to provide epidemiological evidence for the existence of NTDs genetic marker...
  89. Kotsopoulos J, Zhang W, Zhang S, McCready D, Trudeau M, Zhang P, et al. Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res Treat. 2008;112:585-93 pubmed publisher
    ..We observed no association between the MTHFR, RFC, MS and MTRR genotypes and the risk of breast cancer...
  90. Shimasaki N, Mori T, Torii C, Sato R, Shimada H, Tanigawara Y, et al. Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma. J Pediatr Hematol Oncol. 2008;30:347-52 pubmed publisher
    ..We investigated preliminarily whether methylenetetrahydrofolate reductase (MTHFR) 677C/T or reduced folate carrier 1 (RFC1) 80G/A polymorphisms were associated with toxicities during maintenance chemotherapy with mercaptopurine (6MP) and ..
  91. Sisakova A, Altmannova V, Sebesta M, Krejci L. Role of PCNA and RFC in promoting Mus81-complex activity. BMC Biol. 2017;15:90 pubmed publisher
    ..Moreover, this stimulation is not specific to Rfc1, the largest of subunit of this complex, thus indicating that alternative clamp loaders may also play a role in the ..
  92. Bunz F, Kobayashi R, Stillman B. cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A. 1993;90:11014-8 pubmed
    Replication factor C (RFC) is a multisubunit, DNA polymerase accessory protein required for the coordinated synthesis of both DNA strands during simian virus 40 DNA replication in vitro...