REV3L

Summary

Gene Symbol: REV3L
Description: REV3 like, DNA directed polymerase zeta catalytic subunit
Alias: POLZ, REV3, DNA polymerase zeta catalytic subunit, REV3-like, polymerase (DNA directed), zeta, catalytic subunit, Rev-3, yeast, homolog-like (polymerase, DNA, zeta)
Species: human
Products:     REV3L

Top Publications

  1. Hara K, Hashimoto H, Murakumo Y, Kobayashi S, Kogame T, Unzai S, et al. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem. 2010;285:12299-307 pubmed publisher
    ..Polzeta consists of two subunits: the catalytic REV3, which belongs to B family DNA polymerase, and the noncatalytic REV7...
  2. Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H. Structural basis of recruitment of DNA polymerase ? by interaction between REV1 and REV7 proteins. J Biol Chem. 2012;287:33847-52 pubmed
    REV1, REV3, and REV7 are pivotal proteins in translesion DNA synthesis, which allows DNA synthesis even in the presence of DNA damage...
  3. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce C, et al. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem. 2000;275:4391-7 pubmed
    ..cerevisiae Rev3 (hREV3)...
  4. Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce C, et al. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem. 2001;276:35644-51 pubmed
    ..Recently, the human REV1 (hREV1) and REV3 (hREV3) genes were identified, and their products were revealed to be involved in UV-induced mutagenesis, as ..
  5. Gibbs P, McGregor W, Maher V, Nisson P, Lawrence C. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. Proc Natl Acad Sci U S A. 1998;95:6876-80 pubmed
    ..of mutagenic mechanisms in humans, we have cloned and sequenced the human homolog of the Saccharomyces cerevisiae REV3 gene...
  6. Shi T, Yang L, Yang G, Tu X, Wu X, Cheng X, et al. DNA polymerase ? as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer. Med Oncol. 2013;30:500 pubmed publisher
    ..Taken together, Pol? expression can be used as the predictor for poor prognosis, which might be caused by the potential chemoradiation resistance of the cervical cancer patients. The mechanism deserves further exploration. ..
  7. Sharma S, Hicks J, Chute C, Brennan J, Ahn J, Glover T, et al. REV1 and polymerase ? facilitate homologous recombination repair. Nucleic Acids Res. 2012;40:682-91 pubmed publisher
    REV1 and DNA Polymerase ? (REV3 and REV7) play important roles in translesion DNA synthesis (TLS) in which DNA replication bypasses blocking lesions...
  8. Wang H, Zhang S, Wang S, Lu J, Wu W, Weng L, et al. REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro Oncol. 2009;11:790-802 pubmed publisher
    The REV3L gene, encoding the catalytic subunit of human polymerase zeta, plays a significant role in the cytotoxicity, mutagenicity, and chemoresistance of certain tumors...
  9. Hicks J, Chute C, Paulsen M, Ragland R, Howlett N, Gueranger Q, et al. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 2010;30:1217-30 pubmed publisher

More Information

Publications97

  1. Bhat A, Andersen P, Qin Z, Xiao W. Rev3, the catalytic subunit of Pol?, is required for maintaining fragile site stability in human cells. Nucleic Acids Res. 2013;41:2328-39 pubmed publisher
    It has been long speculated that mammalian Rev3 plays an important, yet unknown role(s) during mammalian development, as deletion of Rev3 causes embryonic lethality in mice, whereas no other translesion DNA synthesis polymerases studied ..
  2. Knobel P, Kotov I, Felley Bosco E, Stahel R, Marti T. Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells. Neoplasia. 2011;13:961-70 pubmed
    b>REV3 is the catalytic subunit of DNA translesion synthesis polymerase ?. Inhibition of REV3 expression increases the sensitivity of human cells to a variety of DNA-damaging agents and reduces the formation of resistant cells...
  3. Varadi V, Bevier M, Grzybowska E, Johansson R, Enquist K, Henriksson R, et al. Genetic variation in genes encoding for polymerase ? subunits associates with breast cancer risk, tumour characteristics and survival. Breast Cancer Res Treat. 2011;129:235-45 pubmed publisher
    ..We selected four genes encoding for the catalytic subunits of the polymerases ?, ?, ? and ? (POLB, POLD1, POLQ and REV3L, respectively) and two associated proteins (MAD2L2 and REV1) because of their previously reported association with ..
  4. Kawamura K, O Wang J, Bahar R, Koshikawa N, Shishikura T, Nakagawara A, et al. The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues. Int J Oncol. 2001;18:97-103 pubmed
    Mutagenesis induced by UV light and chemical agents in yeast is largely dependent on the function of Rev3, the catalytic subunit of DNA polymerase zeta that carries out translesion DNA synthesis...
  5. Li Z, Zhang H, McManus T, McCormick J, Lawrence C, Maher V. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts. Mutat Res. 2002;510:71-80 pubmed
    In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-..
  6. Brondello J, Pillaire M, Rodriguez C, Gourraud P, Selves J, Cazaux C, et al. Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta. Oncogene. 2008;27:6093-101 pubmed publisher
    ..Here we focused on Rev3, the catalytic subunit of the low-fidelity DNA repair polymerase zeta...
  7. Zhang S, Chen H, Zhao X, Cao J, Tong J, Lu J, et al. REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. Oncogene. 2013;32:242-50 pubmed publisher
    ..Recent evidence suggests that REV3L has an important role in the maintenance of genome stability despite its mutagenic characteristics...
  8. Díaz Gay M, Franch Expósito S, Arnau Collell C, Park S, Supek F, Muñoz J, et al. Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer. Cancers (Basel). 2019;11: pubmed publisher
    ..i>BRCA2, BLM, ERCC2, RECQL, REV3L and RIF1 were among the most promising candidate genes for germline CRC predisposition...
  9. Jiraskova K, Hughes D, Brezina S, Gumpenberger T, Veskrnova V, Buchler T, et al. Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome. Int J Mol Sci. 2018;20: pubmed publisher
    ..However, only some of the genes (REV3L, POLQ, and NEIL3) were prominently defined as prediction factors in the classification and ..
  10. Kuo I, Huang Y, Lin C, Lin C, Chang W, Lai W, et al. SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes. J Biomed Sci. 2019;26:20 pubmed publisher
    ..DNA repair and damage response-related genes including BRCA1, BRCA2, RAD51, KU80 DNAPK, p21, SIRT1, NFAT5 and REV3L in KYSE510 radio-resistant cells to achieve the sensitization effect to anti-cancer treatment...
  11. Arbel Eden A, Joseph Strauss D, Masika H, Printzental O, Rachi E, Simchen G. Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis. G3 (Bethesda). 2013;3:633-644 pubmed publisher
    ..We find that the three TLSPs of budding yeast Saccharomyces cerevisiae Rev1, PolZeta (Rev3 and Rev7), and Rad30 are induced during meiosis at a time when DNA double-strand breaks (DSBs) are formed and ..
  12. Saha L, Kim S, Kang H, Akter S, Choi K, Sakuma T, et al. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Environ Mol Mutagen. 2018;59:529-538 pubmed publisher
    ..were disrupted in the TK6 B cell line, a human cell line widely used for the MN test: FANCD2, DNA polymerase ζ (REV3), XRCC1, RAD54, and/or LIG4...
  13. Rizzo A, Vassel F, Chatterjee N, D Souza S, Li Y, Hao B, et al. Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex. Proc Natl Acad Sci U S A. 2018;115:E8191-E8200 pubmed publisher
    ..and cell-cycle control, facilitates assembly of this complex by binding Rev1 and the catalytic subunit of Polζ, Rev3. Rev7 interacts with Rev3 by a mechanism conserved among HORMA proteins, whereby an open-to-closed transition locks ..
  14. Shivange G, Kodipelli N, Monisha M, Anindya R. A role for Saccharomyces cerevisiae Tpa1 protein in direct alkylation repair. J Biol Chem. 2014;289:35939-52 pubmed publisher
    ..We further demonstrate that the trans-lesion synthesis DNA polymerase Polζ (REV3) plays a key role in tolerating DNA methyl-base lesions and that tpa1Δmag1revΔ3 triple mutant is extremely ..
  15. Chan K, Resnick M, Gordenin D. The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis. DNA Repair (Amst). 2013;12:878-89 pubmed publisher
    ..We recapitulated previous findings on the roles of REV1 and REV3. Further, we found that sequence context can strongly influence the relative frequency of A or C insertion...
  16. Ræder S, Nepal A, Bjørås K, Seelinger M, Kolve R, Nedal A, et al. APIM-Mediated REV3L⁻PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells. Int J Mol Sci. 2018;20: pubmed publisher
    ..Here we show that the catalytic subunit of the essential mammalian TLS polymerase POLζ, REV3L, contains a functional AlkB homolog 2 PCNA interacting motif, APIM...
  17. Erzurumluoglu A, Liu M, Jackson V, Barnes D, Datta G, Melbourne C, et al. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry. 2019;: pubmed publisher
    ..Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a ..
  18. Jansen J, Tsaalbi Shtylik A, de Wind N. Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease. DNA Repair (Amst). 2015;29:56-64 pubmed publisher
    ..depend on translesion synthesis polymerases Rev1 and Pol ζ, the latter consisting of the catalytic subunit Rev3 and the accessory protein Rev7...
  19. Wojtaszek J, Lee C, D Souza S, Minesinger B, Kim H, D Andrea A, et al. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. J Biol Chem. 2012;287:33836-46 pubmed
    ..a nucleotide opposite the lesion and with the heterodimeric B-family polymerase ζ, consisting of the catalytic Rev3 subunit and the accessory Rev7 subunit, replacing the insertion polymerase to carry out primer extension past the ..
  20. Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
    ..These activities of MAD2L2 depend on ATM kinase activity, RNF8, RNF168, 53BP1 and RIF1, but not on PTIP, REV1 and REV3, the latter two acting with MAD2L2 in translesion synthesis...
  21. Wang F, Yang W. Structural insight into translesion synthesis by DNA Pol II. Cell. 2009;139:1279-89 pubmed publisher
    E. coli DNA Pol II and eukaryotic Rev3 are B-family polymerases that can extend primers past a damaged or mismatched site when the high-fidelity replicative polymerases in the same family are ineffective...
  22. Edwards L, Gupta R, FILIPP F. Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression. Mol Cancer Res. 2016;14:196-206 pubmed publisher
    ..other important pyrimidine-related genes: DPYS, AK9, CAD, CANT1, ENTPD1, NME6, NT5C1A, POLE, POLQ, POLR3B, PRIM2, REV3L, and UPP2 are significantly enriched in somatic mutations relative to the background mutation rate...
  23. Dai C, Chen P, Li J, Lan T, Chen Y, Qian H, et al. Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival. Oncotarget. 2016;7:65157-65170 pubmed publisher
    ..by co-depleting BRCA2 and POLQ was stronger than those by co-depleting BRCA2 and other TLS factors including POLH, REV3, or REV1...
  24. Hoopes J, Hughes A, Hobson L, Cortez L, Brown A, Roberts S. Avoidance of APOBEC3B-induced mutation by error-free lesion bypass. Nucleic Acids Res. 2017;45:5243-5254 pubmed publisher
    ..Strains lacking Apn1, Apn2, Ntg1, Ntg2 or Rev3 displayed wild-type frequencies of APOBEC3B-induced canavanine resistance (CanR)...
  25. Tomida J, Takata K, Lange S, Schibler A, Yousefzadeh M, Bhetawal S, et al. REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ?. Nucleic Acids Res. 2015;43:1000-11 pubmed publisher
    DNA polymerase zeta (pol ?) is exceptionally important for controlling mutagenesis and genetic instability. REV3L comprises the catalytic subunit, while REV7 (MAD2L2) is considered an accessory subunit...
  26. Stone J, Lujan S, Kunkel T. DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae. Environ Mol Mutagen. 2012;53:777-86 pubmed publisher
    ..mutations generated in Saccharomyces cerevisiae when either wild-type Pol ζ or a mutator Pol ζ variant (rev3-L979F) bypasses endogenous lesions...
  27. Jin S, Fu H, Sun S, Jiang S, Xiong Y, Gong Y, et al. iTRAQ-based quantitative proteomic analysis of the androgenic glands of the oriental river prawn, Macrobrachium nipponense, during nonreproductive and reproductive seasons. Comp Biochem Physiol Part D Genomics Proteomics. 2018;26:50-57 pubmed publisher
    ..Additional qPCR analysis of the 10 DEPs in testes, ovaries, and androgenic glands showed that Gem, Ferritin, and Rev3 were highly expressed in the androgenic gland, implying importance in male sexual development, given the important ..
  28. Hashimoto K, Takeda S, Swenberg J, Nakamura J. Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells. Mutagenesis. 2015;30:821-8 pubmed publisher
    ..DT40 cells and mutant cells were exposed to the preactivated CP, CP caused increased cytotoxicity in FANC-, RAD9-, REV3- and RAD18-mutant cells compared to isogenic wild-type cells...
  29. Makarova A, Burgers P. Eukaryotic DNA polymerase ζ. DNA Repair (Amst). 2015;29:47-55 pubmed publisher
    ..The lagging strand DNA polymerase δ shares the small Pol31 and Pol32 subunits with the Rev3-Rev7 core assembly giving a four subunit Pol ζ complex that is the active form in mutagenesis...
  30. Luo H, Chen Z, Wang S, Zhang R, Qiu W, Zhao L, et al. c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma. Brain. 2015;138:3654-72 pubmed publisher
    ..we report that loss of miR-29c via c-Myc drives the acquisition of temozolomide resistance through enhancement of REV3L-mediated DNA repair and mutagenesis in glioblastoma...
  31. Nishihara K, Huang R, Zhao J, Shahane S, Witt K, Smith Roe S, et al. Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform. Mutagenesis. 2016;31:69-81 pubmed publisher
    ..Tox21 10K compound library against two isogenic DNA repair-deficient DT40 cell lines (KU70 (-/-) /RAD54 (-/-) and REV3 (-/-) ) and the wild-type cell line using a cell viability assay that measures intracellular adenosine triphosphate ..
  32. Pustovalova Y, Magalhães M, D Souza S, Rizzo A, Korza G, Walker G, et al. Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis. Biochemistry. 2016;55:2043-53 pubmed publisher
    ..In the second step, a four-subunit B-family DNA polymerase Polζ (Rev3/Rev7/PolD2/PolD3 complex) extends the distorted DNA primer-template...
  33. Uchiyama M, Terunuma J, Hanaoka F. The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage. PLoS ONE. 2015;10:e0130000 pubmed publisher
    ..In fission yeast, Eso1 (polη), Kpa1/DinB (polκ), Rev1, and Polζ (a complex of Rev3 and Rev7) have been identified as translesion synthesis polymerases...
  34. Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed publisher
    ..also functions in DNA repair, as well as the translesion synthesis polymerase Pol ?, whose catalytic subunit is REV3L. In cells depleted of POLD1 or POLD3 we found a differential but general increase in genome instability as ..
  35. Segovia R, Shen Y, Lujan S, Jones S, Stirling P. Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast. Proc Natl Acad Sci U S A. 2017;114:2663-2668 pubmed publisher
  36. Lange S, Tomida J, Boulware K, Bhetawal S, Wood R. The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability. PLoS Genet. 2016;12:e1005759 pubmed publisher
    DNA polymerase ζ (pol ζ) is exceptionally important for maintaining genome stability. Inactivation of the Rev3l gene encoding the polymerase catalytic subunit causes a high frequency of chromosomal breaks, followed by lethality in ..
  37. Kobbe S, Trapp O, Knoll A, Manuss A, Puchta H. The Translesion Polymerase ζ Has Roles Dependent on and Independent of the Nuclease MUS81 and the Helicase RECQ4A in DNA Damage Repair in Arabidopsis. Plant Physiol. 2015;169:2718-29 pubmed publisher
    b>DNA polymerase zeta catalytic subunit REV3 is known to play an important role in the repair of DNA damage induced by cross-linking and methylating agents...
  38. Armitage A, Barbara D, Harrison R, Lane C, Sreenivasaprasad S, Woodhall J, et al. Discrete lineages within Alternaria alternata species group: Identification using new highly variable loci and support from morphological characters. Fungal Biol. 2015;119:994-1006 pubmed publisher
    ..alternata species group. These loci included three new phylogenetic loci (TMA22, PGS1, and REV3) identified as highly variable based on publically available genome sequence data for Dothideomycete species...
  39. Vaccari C, Tassano E, Torre M, Gimelli S, Divizia M, Romanini M, et al. Assessment of copy number variations in 120 patients with Poland syndrome. BMC Med Genet. 2016;17:89 pubmed
    ..a number of candidate genes possibly causing the developmental defects observed in PS patients, among others REV3L, a gene coding for an error-prone DNA polymerase previously associated with Möbius Syndrome with variable ..
  40. Liu Y, Wu X, Hu X, Chen Z, Liu H, Takeda S, et al. Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage. Toxicol In Vitro. 2017;42:130-138 pubmed publisher
    ..HR) mutants of Brca1-/- and Brca2-/- and translesion DNA synthesis (TLS) mutants of Rev3-/- and Rad18-/- were more sensitive to RSV...
  41. Ooka M, Takazawa H, Takeda S, Hirota K. Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation. Chemosphere. 2016;144:1901-7 pubmed publisher
    ..The REV3(-/-) mutant cell line exhibited the highest sensitivity, in terms of increased cytotoxicity, to the both compounds ..
  42. Bhat A, Qin Z, Wang G, Chen W, Xiao W. Rev7, the regulatory subunit of Polζ, undergoes UV-induced and Cul4-dependent degradation. FEBS J. 2017;284:1790-1803 pubmed publisher
    In eukaryotic cells, Rev7 interacts with Rev3 and functions as a regulatory subunit of Polζ, a translesion DNA synthesis (TLS) polymerase...
  43. Mumbrekar K, Bola Sadashiva S, Kabekkodu S, Fernandes D, Vadhiraja B, Suga T, et al. Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017;97:118-127 pubmed publisher
    ..We tested 22 genetic variants reported in 18 genes (ie, NFE2L2, OGG1, NEIL3, RAD17, PTTG1, REV3L, ALAD, CD44, RAD9A, TGF?R3, MAD2L2, MAP3K7, MAT1A, RPS6KB2, ZNF830, SH3GL1, BAX, and XRCC1) using TaqMan assay-..
  44. Esteban Jurado C, Franch Expósito S, Muñoz J, Ocaña T, Carballal S, Lopez Ceron M, et al. The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. Eur J Hum Genet. 2016;24:1501-5 pubmed publisher
    ..carried heterozygous, rare, potentially pathogenic variants located in BRCA2/FANCD1, BRIP1/FANCJ, FANCC, FANCE and REV3L/POLZ...
  45. Singh B, Li X, Owens K, Vanniarajan A, Liang P, Singh K. Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome. PLoS ONE. 2015;10:e0140409 pubmed publisher
    ..Here we demonstrate localization of REV3 DNA polymerase in the mammalian mitochondria...
  46. Yang L, Shi T, Liu F, Ren C, Wang Z, Li Y, et al. REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells. PLoS ONE. 2015;10:e0120334 pubmed publisher
    b>REV3L, the catalytic subunit of DNA Polymerase ζ (Polζ), plays a significant role in the DNA damage tolerance mechanism of translesion synthesis (TLS). The role of REV3L in chemosensitivity of cervical cancer needs exploration...
  47. Jongsma G, Barej M, Barratt C, Burger M, Conradie W, Ernst R, et al. Diversity and biogeography of frogs in the genus Amnirana (Anura: Ranidae) across sub-Saharan Africa. Mol Phylogenet Evol. 2018;120:274-285 pubmed publisher
    ..Using multiple loci from the mitochondrial (16S) and nuclear genomes (DISP2, FICD, KIAA2013, REV3L), we generated a strongly supported species-level phylogeny that provides insights into the continental ..
  48. Lee Y, Gregory M, Yang W. Human Pol ? purified with accessory subunits is active in translesion DNA synthesis and complements Pol ? in cisplatin bypass. Proc Natl Acad Sci U S A. 2014;111:2954-9 pubmed publisher
    ..At a minimum, Pol ? consists of a catalytic subunit Rev3 and an accessory subunit Rev7...
  49. Wood C, Kohli S, Malcolm E, Allison C, Shoaib M. Subtype-selective nicotinic acetylcholine receptor agonists can improve cognitive flexibility in an attentional set shifting task. Neuropharmacology. 2016;105:106-113 pubmed publisher
    ..extra-dimensional (ED) shift performance, nicotine, 5IA-85380 and SSR180711 further enhanced the final reversal (REV3) stage of the task...
  50. Hashimoto K, Cho Y, Yang I, Akagi J, Ohashi E, Tateishi S, et al. The vital role of polymerase ? and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ? by REV1 to replication-stalled site. J Biol Chem. 2012;287:9613-22 pubmed publisher
    ..Knockout of the Rev1 gene decreased both the TLS efficiency and the miscoding frequency. Knockout of the Rev3L gene, coding for the catalytic subunit of pol ?, caused even greater decreases in these two TLS parameters; almost ..
  51. Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, et al. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J Biol Chem. 2017;292:17658-17667 pubmed publisher
    ..Structures of MAD2L2 in complex with binding regions of the TLS proteins REV3 and REV1 have revealed that MAD2L2 has two faces for protein-protein interactions that are regulated by its C-..
  52. Govind N, Choudhury A, Hodkinson B, Ickinger C, Frost J, Lee A, et al. Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans. Mol Med. 2014;20:341-9 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) in the intergenic regions LOC389203|RBPJ, LOC100131131|IL1R1, KIAA1919|REV3L, LOC643749|TRAF3IP2, and SNPs in the intron and untranslated regions (UTR) of IRF1 and the intronic region of ICOS ..
  53. Lin Y, Owen N, Minko I, Lange S, Tomida J, Li L, et al. DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci U S A. 2016;113:13774-13779 pubmed
    ..Following challenge with AFB1, survival of mouse cells deficient in pol ζ (Rev3L-/-) was significantly reduced relative to Rev3L+/- cells or Rev3L-/- cells ..
  54. Wang J, Liu Q, Yuan S, Xie W, Liu Y, Xiang Y, et al. Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies. Sci Rep. 2017;7:8371 pubmed publisher
    ..ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer ..
  55. Wang W, Sheng W, Yu C, Cao J, Zhou J, Wu J, et al. REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells. Oncol Rep. 2015;34:1460-8 pubmed publisher
    ..b>REV3L is the catalytic subunit of Pol ζ...
  56. Suzuki T, Gruz P, Honma M, Adachi N, Nohmi T. Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ? to genotoxic stresses. DNA Repair (Amst). 2016;45:34-43 pubmed publisher
    ..Similarities and differences in in vivo roles of yeast and human Pol ? in genome integrity are discussed. ..
  57. Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H. Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:962-4 pubmed publisher
    REV1, REV3 and REV7 are pivotal proteins in translesion DNA synthesis that allows DNA synthesis to continue even in the presence of DNA damage...
  58. Hara K, Shimizu T, Unzai S, Akashi S, Sato M, Hashimoto H. Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1302-5 pubmed publisher
    ..In DNA replication, REV7 interacts with REV3 and forms DNA polymerase zeta, which plays a central role in error-prone DNA synthesis...
  59. Quinet A, Martins D, Vessoni A, Biard D, Sarasin A, Stary A, et al. Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells. Nucleic Acids Res. 2016;44:5717-31 pubmed publisher
    ..Here, we investigated the involvement of Pol?, Rev1 and Rev3L (Pol? catalytic subunit) in the specific bypass of 6-4PP and CPD in repair-deficient XP-C human cells...
  60. Sui Y, Li Y, Jin C, Xu F. [Roles of REV3 in proliferation and genomic stability of colon carcinoma cells]. Yi Chuan. 2010;32:467-72 pubmed
    To investigate the roles of human REV3 gene in proliferation and genomic stability, we experimentally suppressed the REV3 expression in human colon cancer cells (SW480) by the interference RNA technology (RNAi) as monitored by real-time ..
  61. Morelli C, Mungall A, Negrini M, Barbanti Brodano G, Croce C. Alternative splicing, genomic structure, and fine chromosome localization of REV3L. Cytogenet Cell Genet. 1998;83:18-20 pubmed
    We have localized a human homolog, REV3L, of the Saccharomyces cerevisiae REV3 gene on chromosome region 6q21...
  62. Masutani C, Kusumoto R, Iwai S, Hanaoka F. Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J. 2000;19:3100-9 pubmed
  63. Raykov V, Marvin M, Louis E, Maringele L. Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms. Genetics. 2016;203:1659-68 pubmed publisher
    ..This study also uncovered an important role for Rev3 and Rev7 (but not for Pol32) subunits of polymerase ? in the survival of cells undergoing telomere losses and ..
  64. Strange A, Capon F, Spencer C, Knight J, Weale M, Allen M, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 2010;42:985-90 pubmed publisher
    ..Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis. ..
  65. Jäger S, Wahl S, Kröger J, Sharma S, Hoffmann P, Floegel A, et al. Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes. Sci Rep. 2017;7:6037 pubmed publisher
    ..genetic variants consistently associated with diabetes-related metabolites, two (rs174550 (FADS1), rs3204953 (REV3L)) were significantly associated with type 2 diabetes in large-scale meta-analysis for type 2 diabetes...
  66. Goričar K, Kovac V, Dolzan V. Polymorphisms in translesion polymerase genes influence treatment outcome in malignant mesothelioma. Pharmacogenomics. 2014;15:941-50 pubmed publisher
    We evaluated the influence of genetic variability in translesion polymerases REV1 and REV3L on the outcome of cisplatin treatment in malignant mesothelioma patients...
  67. Young M. Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance. Front Mol Biosci. 2017;4:74 pubmed publisher
    ..review examines: (1) mtDNA maintenance in human health and disease, (2) reports of DNA polymerases theta and zeta (Rev3) localizing to mitochondria, and (3) additional drugs with off-target effects on mitochondrial function...
  68. Zhu X, Zou S, Zhou J, Zhu H, Zhang S, Shang Z, et al. REV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma. Oncol Rep. 2016;35:1664-70 pubmed publisher
    Protein reversionless 3-like (REV3L), the catalytic subunit of DNA polymerase (pol) ζ, is well known to participate in error-prone translesion synthesis (TLS) with less stringent and lower processivity...
  69. Zhu F, Jin C, Song T, Yang J, Guo L, Yu Y. Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis. World J Gastroenterol. 2003;9:888-93 pubmed
    To understand the response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and its role in human mutagenesis...
  70. Jiang H, Chen P, Su J, Wu M, Qian H, Wang Y, et al. Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells. J Cell Physiol. 2017;232:3433-3443 pubmed publisher
    It has been demonstrated that REV3, the catalytic subunit of the translesion synthesis (TLS) polymerase ?, play an important role in DNA damage response (DDR) induced by cisplatin, and Ataxia-telangietasia mutated and Rad-3-related (ATR) ..
  71. Patel R, Liu D, Gonzaga Jauregui C, Jhangiani S, Lu J, Sutton V, et al. An exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and a TUBB3 mutation. Cold Spring Harb Mol Case Stud. 2017;3:a000984 pubmed publisher
    ..Although no such gene was identified and we did not find mutations in PLXND1 and REV3L, we found a de novo heterozygous mutation, p...
  72. Hashimoto K, Bonala R, Johnson F, Grollman A, Moriya M. Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells. DNA Repair (Amst). 2016;46:55-60 pubmed publisher
    ..Similarly, knockout of the Rev1 gene did not significantly affect TLS. However, knockout of the Rev3l gene, coding for the catalytic subunit of pol?, drastically suppressed TLS and abolished dA-AL-I to T ..
  73. Pustovalova Y, Bezsonova I, Korzhnev D. The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase ? and Rev7 subunit of polymerase ?. FEBS Lett. 2012;586:3051-6 pubmed publisher
  74. Fritzen R, Delbos F, De Smet A, Palancade B, Canman C, Aoufouchi S, et al. A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro. DNA Repair (Amst). 2016;46:37-46 pubmed publisher
    ..of yeast DNA polymerase ?, is required for UV resistance and UV-induced mutagenesis, while its mammalian ortholog, REV3L, plays further vital roles in cell proliferation and embryonic development...
  75. Lin W, Wu X, Wang Z. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans. Mutat Res. 1999;433:89-98 pubmed
    ..In the yeast Saccharomyces cerevisiae, DNA damage-induced mutagenesis pathway requires the REV3 gene...
  76. Kotov I, Siebring van Olst E, Knobel P, van der Meulen Muileman I, Felley Bosco E, van Beusechem V, et al. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Mol Oncol. 2014;8:1747-59 pubmed publisher
    b>REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair...
  77. Li F, Ball L, Fan L, Hanna M, Xiao W. Sgs1 helicase is required for efficient PCNA monoubiquitination and translesion DNA synthesis in Saccharomyces cerevisiae. Curr Genet. 2018;64:459-468 pubmed publisher
    ..Surprisingly, a synthetic genetic array (SGA) screen using rev1 and rev3 as baits did not reveal an anticipated synthetic effect with sgs1, indicating a possible involvement of Sgs1 in TLS...
  78. Tomas Roca L, Tsaalbi Shtylik A, Jansen J, Singh M, Epstein J, Altunoglu U, et al. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nat Commun. 2015;6:7199 pubmed publisher
    ..Here, we report de novo mutations affecting two genes, PLXND1 and REV3L in MBS patients...
  79. Actis M, Ambaye N, Evison B, Shao Y, Vanarotti M, Inoue A, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016;24:4339-4346 pubmed publisher
    ..The mammalian DNA polymerase ?, which comprises the catalytic subunit REV3L and the non-catalytic subunit REV7, is essential for ICLR...
  80. Huang K, Jang K, Kim S, Kim H, Kim S, Kwon H, et al. Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. Sci Rep. 2016;6:19552 pubmed publisher
    ..Somatic mutations in REV3L, the gene encoding the catalytic subunit of DNA polymerase ζ involved in translesional synthesis, are ..
  81. Xu F, Li Y. [Role of hREV3 in cell cycle and proliferation]. Yi Chuan. 2008;30:1003-7 pubmed
    Using a stable human kidney embryonic cell line HEK-293-M-REV3- in which the REV3 gene expression is suppressed by antisense RNA, we measured cell cycle progression and proliferation in an attempt to valuate the roles of REV3 in ..
  82. Wang A, Gregoire S, Zika E, Xiao L, Li C, Li H, et al. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. J Biol Chem. 2005;280:29117-27 pubmed
    ..These results identify ANKRA, RFXANK, and CIITA as novel targets of class IIa HDACs and suggest that these deacetylases play a role in regulating MHCII expression. ..
  83. Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, et al. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells. 2004;9:523-31 pubmed
    ..Thus, our results suggest that hREV1 plays a pivotal role in the multi-enzyme, multi-step process of translesion DNA synthesis. ..
  84. Karayianni E, Magnanini C, Orphanos V, Negrini M, Maniatis G, Spathas D, et al. Transcriptional map of chromosome region 6q16-->q21. Cytogenet Cell Genet. 1999;86:263-6 pubmed
    ..From this transcription map it is possible to derive a large region of synteny with mouse chromosome 10. ..
  85. Xiao W, Lechler T, Chow B, Fontanie T, Agustus M, Carter K, et al. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta. Carcinogenesis. 1998;19:945-9 pubmed
    The Saccharomyces cerevisiae REV3 gene encodes the catalytic subunit of a non-essential DNA polymerase zeta, which is required for mutagenesis. The rev3 mutants significantly reduce both spontaneous and DNA damage-induced mutation rates...
  86. Kong L, Murata M, Digman M. Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells. Biochem Biophys Res Commun. 2018;496:199-204 pubmed publisher
    ..However, there is much debate over the roles of the reversionless 3-like (REV3L) protein responsible for TLS and p53 in regulating cancer cell metabolism...
  87. Daly J, Bebenek K, Watt D, Richter K, Jiang C, Zhao M, et al. Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity. J Immunol. 2012;188:5528-37 pubmed publisher
    ..Combined, these data are best explained by a direct role for DNA polymerase ζ in Ig hypermutation. ..
  88. Ziv O, Geacintov N, Nakajima S, Yasui A, Livneh Z. DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci U S A. 2009;106:11552-7 pubmed publisher
    ..This presents an extreme example of benefit-risk balance in the activity of TLS polymerases, which provide protection against UV cytotoxicity at the cost of increased mutagenic load. ..