resistin

Summary

Gene Symbol: resistin
Description: resistin
Alias: ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin, C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1, adipose tissue-specific secretory factor, c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, cysteine-rich secreted protein A12-alpha-like 2, cysteine-rich secreted protein FIZZ3, found in inflammatory zone 3, resistin delta2
Species: human
Products:     resistin

Top Publications

  1. McTernan P, McTernan C, Chetty R, Jenner K, Fisher F, Lauer M, et al. Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab. 2002;87:2407 pubmed
    b>Resistin, a novel signalling molecule isolated in mice has been suggested to be the putative hormone thought to link obesity with type 2 diabetes...
  2. Osawa H, Onuma H, Ochi M, Murakami A, Yamauchi J, Takasuka T, et al. Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. Biochem Biophys Res Commun. 2005;335:596-602 pubmed
    b>Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source in humans remain unknown...
  3. Olszanecka Glinianowicz M, Kuglin D, Dąbkowska Huć A, Skałba P. Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011;154:51-6 pubmed publisher
    ..The aim of the study was to assess the relationship between plasma adiponectin and resistin levels and insulin resistance and markers of hyperandrogenism in lean and obese PCOS women...
  4. Li F, Wang F, Nie F, Li Z, Huang Y, Zhang J, et al. [The effects of glucose fluctuation on resistin]. Zhonghua Nei Ke Za Zhi. 2010;49:484-7 pubmed
    To explore the effect of glucose fluctuation on resistin. The phorbol-12-myristate-13-acetate(PMA)-activated and differentiated U937 cells were exposed to experimental condition for 3 days, three groups of cells were formed, each one ..
  5. Choi H, Kim S, Yang S, Yoo H, Seo J, Kim S, et al. Association of adiponectin, resistin, and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography. Arterioscler Thromb Vasc Biol. 2011;31:944-9 pubmed publisher
    Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis...
  6. Hartman H, Hu X, Tyler K, Dalal C, Lazar M. Mechanisms regulating adipocyte expression of resistin. J Biol Chem. 2002;277:19754-61 pubmed
    Resistin, also known as Adipocyte Secreted Factor (ADSF) and Found in Inflammatory Zone 3 (FIZZ3), is a mouse protein with potential roles in insulin resistance and adipocyte differentiation...
  7. Fujinami A, Obayashi H, Ohta K, Ichimura T, Nishimura M, Matsui H, et al. Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes. Clin Chim Acta. 2004;339:57-63 pubmed
    b>Resistin is a recently identified adipocyte-secreted hormone in rodents, and has been proposed to serve as a link between obesity and insulin resistance...
  8. Jones T, Basilio J, Brophy P, McCammon M, Hickner R. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity (Silver Spring). 2009;17:1189-95 pubmed publisher
    ..lipoprotein (LDL) cholesterol, triglycerides, leptin, active ghrelin, total peptide YY (PYY), adiponectin, and resistin concentrations were measured...
  9. Kemmotsu Y, Saji T, Kusunoki N, Tanaka N, Nishimura C, Ishiguro A, et al. Serum adipokine profiles in Kawasaki disease. Mod Rheumatol. 2012;22:66-72 pubmed publisher
    ..Serum resistin, high-molecular-weight (HMW) adiponectin, leptin, and visfatin levels were measured by enzyme-linked ..

More Information

Publications132 found, 100 shown here

  1. Tsiotra P, Tsigos C, Anastasiou E, Yfanti E, Boutati E, Souvatzoglou E, et al. Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women. Mediators Inflamm. 2008;2008:892864 pubmed publisher
    b>Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive...
  2. McTernan P, Fisher F, Valsamakis G, Chetty R, Harte A, McTernan C, et al. Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin Endocrinol Metab. 2003;88:6098-106 pubmed
    b>Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes in rodent models, but its relevance to human diabetes remains uncertain...
  3. Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, et al. Systematic search for single nucleotide polymorphisms in the resistin gene: the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes. Diabetes. 2002;51:863-6 pubmed
    b>Resistin is a novel polypeptide specifically secreted from adipocytes, and its serum levels are increased in obese diabetic mice. Resistin antagonizes insulin and could account for insulin resistance...
  4. Patel L, Buckels A, Kinghorn I, Murdock P, Holbrook J, Plumpton C, et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun. 2003;300:472-6 pubmed
    b>Resistin is a cysteine-rich protein postulated to be a molecular link between obesity and type 2 diabetes...
  5. Thommesen L, Stunes A, Monjo M, Grøsvik K, Tamburstuen M, Kjøbli E, et al. Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism. J Cell Biochem. 2006;99:824-34 pubmed
    ..secretion of a range of biologically active proteins, called adipokines, for example, leptin, adiponectin, and resistin. Leptin has previously been shown to be expressed in osteoblasts and to promote bone mineralization, whereas ..
  6. Rae C, Graham A. Human resistin promotes macrophage lipid accumulation. Diabetologia. 2006;49:1112-4 pubmed
  7. Ochi M, Osawa H, Hirota Y, Hara K, Tabara Y, Tokuyama Y, et al. Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes. Diabetes. 2007;56:2834-8 pubmed
    b>Resistin is an adipocyte-secreted cytokine associated with insulin resistance in mice...
  8. Wågsäter D, Mumtaz M, Lofgren S, Hugander A, Dimberg J. Resistin in human colorectal cancer: increased expression independently of resistin promoter -420C > G genotype. Cancer Invest. 2008;26:1008-14 pubmed publisher
    A single nucleotide polymorphism (SNP) -420C > G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found...
  9. Holcomb I, Kabakoff R, Chan B, Baker T, Gurney A, Henzel W, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000;19:4046-55 pubmed
    ..In vivo, FIZZ1 may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonary inflammation. ..
  10. Kumor A, Daniel P, Pietruczuk M, Małecka Panas E. Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis. 2009;24:275-81 pubmed publisher
    Leptin, adiponectin, and resistin are the proteins secreted by adipocytes, which affects the metabolism. While the role of leptin in colon carcinogenesis is documented, the effect of adiponectin and resistin remains unclear...
  11. Zhang J, Zhou L, Tang L, Xu L. The plasma level and gene expression of resistin in polycystic ovary syndrome. Gynecol Endocrinol. 2011;27:982-7 pubmed publisher
    To investigate the relationship between plasma resistin, polycystic ovary syndrome (PCOS), and insulin resistance (IR)...
  12. Gonullu G, Kahraman H, Bedir A, Bektas A, Yucel I. Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis. 2010;25:205-12 pubmed publisher
    In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance...
  13. Dalamaga M, Sotiropoulos G, Karmaniolas K, Pelekanos N, Papadavid E, Lekka A. Serum resistin: a biomarker of breast cancer in postmenopausal women? Association with clinicopathological characteristics, tumor markers, inflammatory and metabolic parameters. Clin Biochem. 2013;46:584-90 pubmed publisher
    Previous few studies have shown that resistin is significantly elevated in breast cancer (BC) patients...
  14. Xu J, Sham P, Xu A, Tso A, Wat N, Cheng K, et al. Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study. Clin Endocrinol (Oxf). 2007;66:211-7 pubmed
    Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity...
  15. Zhang M, Na B, Schiller N, Whooley M. Association of resistin with heart failure and mortality in patients with stable coronary heart disease: data from the heart and soul study. J Card Fail. 2011;17:24-30 pubmed publisher
    b>Resistin is a pro-inflammatory signaling molecule that is thought to contribute to atherosclerosis...
  16. Smith S, Bai F, Charbonneau C, Janderová L, Argyropoulos G. A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes. 2003;52:1611-8 pubmed
    ..The adipocyte secreted hormone resistin has been proposed as a link between the adipocyte and insulin resistance by inhibition of insulin-stimulated ..
  17. Calabro P, Samudio I, Willerson J, Yeh E. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation. 2004;110:3335-40 pubmed
    b>Resistin, a novel adipokine, is elevated in patients with type 2 diabetes and may play a role in the vascular complications of this disorder. One recent study has shown that resistin has a proinflammatory effect on endothelial cells...
  18. Migita K, Maeda Y, Miyashita T, Kimura H, Nakamura M, Ishibashi H, et al. The serum levels of resistin in rheumatoid arthritis patients. Clin Exp Rheumatol. 2006;24:698-701 pubmed
    Adipocyte-derived resistin is a circulating protein implicated in insulin resistance, but the role of human resistin is uncertain because it is produced largely by macrophages...
  19. On Y, Park H, Hyon M, Jeon E. Serum resistin as a biological marker for coronary artery disease and restenosis in type 2 diabetic patients. Circ J. 2007;71:868-73 pubmed
    b>Resistin is an adipocyte-secreted hormone. The relationship between circulating resistin concentrations and atherosclerotic coronary artery disease (CAD) in type 2 diabetic patients, if any, remains poorly understood...
  20. Dimitriadis K, Tsioufis C, Selima M, Tsiachris D, Miliou A, Kasiakogias A, et al. Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension. J Hum Hypertens. 2009;23:668-73 pubmed publisher
    b>Resistin, a newly discovered protein, promotes endothelial dysfunction and proinflammatory activation, contributing to subclinical atherosclerosis in different clinical settings...
  21. Tang N, Wang L, Yang L, Zhou B, Gu H, Sun Q, et al. A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population. Clin Endocrinol (Oxf). 2008;68:82-7 pubmed
    b>Resistin, a novel adipocyte-derived peptide, has been linked to the pathogenesis of atherosclerosis. Recently, -420C>G, a variant located in the promoter region of the resistin gene (RETN) was identified...
  22. Melone M, Wilsie L, Palyha O, Strack A, Rashid S. Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9. J Am Coll Cardiol. 2012;59:1697-705 pubmed publisher
    In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes...
  23. Engert J, Vohl M, Williams S, Lepage P, Loredo Osti J, Faith J, et al. 5' flanking variants of resistin are associated with obesity. Diabetes. 2002;51:1629-34 pubmed
    Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice...
  24. Vozarova de Courten B, Degawa Yamauchi M, Considine R, Tataranni P, Volarova de Courten B. High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes. 2004;53:1279-84 pubmed
    b>Resistin is an adipokine with putative prodiabetogenic properties. Like other hormones secreted by adipose tissue, resistin is being investigated as a possible etiologic link between excessive adiposity and insulin resistance...
  25. Lau C, Muniandy S. Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study. Cardiovasc Diabetol. 2011;10:8 pubmed publisher
    Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis...
  26. Yoshino T, Kusunoki N, Tanaka N, Kaneko K, Kusunoki Y, Endo H, et al. Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis. Intern Med. 2011;50:269-75 pubmed
    ..Serum levels of resistin, leptin, and adiponectin were measured by enzyme-linked immunosorbent assay in 141 patients (110 women) who ..
  27. Menzaghi C, Salvemini L, Fini G, Thompson R, Mangiacotti D, Di Paola R, et al. Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals. PLoS ONE. 2012;7:e38414 pubmed publisher
    High serum resistin levels have been associated with kidney dysfunction. Most of these studies have been carried out in individuals with severe kidney impairment, diabetes, cardiovascular disease and related treatments...
  28. Tsiotra P, Boutati E, Dimitriadis G, Raptis S. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int. 2013;2013:487081 pubmed publisher
    b>Resistin and the proinflammatory cytokines, such as TNF- ? , IL-6, and IL-1 ? , produced by adipocytes, and macrophages, are considered to be important modulators of chronic inflammation contributing to the development of obesity and ..
  29. Ochi M, Osawa H, Onuma H, Murakami A, Nishimiya T, Shimada F, et al. The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. Diabetes Res Clin Pract. 2003;61:191-8 pubmed
    b>Resistin, specifically secreted from adipocytes, antagonizes insulin and represents a promising candidate gene for type 2 diabetes...
  30. Lu H, Wang H, Wen Y, Zhang M, Lin H. Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes. World J Gastroenterol. 2006;12:1747-51 pubmed
    To detect plasma levels of new adipocyte derived hormone adiponectin and resistin in type 2 diabetes patients and to explore their potential roles in insulin resistance in type 2 diabetes...
  31. Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, et al. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia. 2010;53:234-46 pubmed publisher
    b>Resistin is a cytokine derived from adipose tissue and is implicated in obesity-related insulin resistance and type 2 diabetes mellitus. Polymorphisms of the resistin gene (RETN) have been shown to affect the plasma resistin concentration...
  32. Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H, et al. The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet. 2004;75:678-86 pubmed
    Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). Resistin, an adipocyte-secreted hormone, antagonizes insulin...
  33. Menzaghi C, Coco A, Salvemini L, Thompson R, De Cosmo S, Doria A, et al. Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. J Clin Endocrinol Metab. 2006;91:2792-5 pubmed
    Serum levels of resistin are believed to modulate insulin resistance in humans...
  34. Malyszko J, Malyszko J, Pawlak K, Mysliwiec M. Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients. Transplant Proc. 2006;38:3434-6 pubmed
    Among patients without chronic kidney disease, resistin, an adipocytokine, has been related to inflammatory markers, coronary artery disease, and cardiovascular disease in the metabolic syndrome...
  35. Sheng C, Di J, Jin Y, Zhang Y, Wu M, Sun Y, et al. Resistin is expressed in human hepatocytes and induces insulin resistance. Endocrine. 2008;33:135-43 pubmed publisher
    b>Resistin, known as an adipocyte-specific secretory factor (ADSF), is implicated to modulate insulin resistance in rodents. However, the precise role of this factor for human insulin resistance has remained elusive...
  36. Pizzuti A, Argiolas A, Di Paola R, Baratta R, Rauseo A, Bozzali M, et al. An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. J Clin Endocrinol Metab. 2002;87:4403-6 pubmed
    b>Resistin is overexpressed in human adipose tissue of obese individuals and is likely to modulate insulin sensitivity. Resistin is, therefore, a candidate gene for insulin resistance...
  37. Bouchard L, Weisnagel S, Engert J, Hudson T, Bouchard C, Vohl M, et al. Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Québec Family Study. J Endocrinol Invest. 2004;27:1003-9 pubmed
    Obesity and insulin resistance are common features of Type 2 Diabetes. A new protein called resistin has been shown to be secreted by adipocytes in mice and to influence insulin sensitivity...
  38. Chen C, Jiang J, Lu J, Chai H, Wang X, Lin P, et al. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2010;299:H193-201 pubmed publisher
    b>Resistin is a newly discovered adipocyte-derived cytokine that may play an important role in insulin resistance, diabetes, adipogenesis, inflammation, and cardiovascular disease...
  39. Heilbronn L, Rood J, Janderova L, Albu J, Kelley D, Ravussin E, et al. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab. 2004;89:1844-8 pubmed
    Early reports suggested that resistin is associated with obesity and insulin resistance in rodents. However, subsequent studies have not supported these findings...
  40. Kunnari A, Ukkola O, Kesaniemi Y. Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients. Diabet Med. 2005;22:583-9 pubmed
    b>Resistin is a hormone secreted by adipocytes and it is also expressed in monocytes. Resistin has been found to increase insulin resistance, a key feature in Type 2 diabetes...
  41. Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, et al. Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care. 2007;30:1501-6 pubmed
    b>Resistin, secreted from adipocytes, causes insulin resistance in rodents...
  42. Tejero M, Voruganti V, Proffitt J, Curran J, Göring H, Johnson M, et al. Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon. Heredity (Edinb). 2008;101:60-6 pubmed publisher
    b>Resistin has been associated with inflammation and risk for cardiovascular disease...
  43. Ma X, Warram J, Trischitta V, Doria A. Genetic variants at the resistin locus and risk of type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002;87:4407-10 pubmed
    b>Resistin is a newly identified hormone secreted by adipocytes that inhibits insulin action on peripheral tissues...
  44. Krassas G, Pontikides N, Loustis K, Koliakos G, Constantinidis T, Panidis D. Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition. Eur J Endocrinol. 2005;153:217-21 pubmed
    b>Resistin is a recently discovered peptide hormone that belongs to a family of tissue-specific resistin-like molecules...
  45. Nagaev I, Bokarewa M, Tarkowski A, Smith U. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS ONE. 2006;1:e31 pubmed
    The characteristics of human resistin (RETN) are unclear and controversial despite intensive adipose-focused research...
  46. Koskinen A, Vuolteenaho K, Moilanen T, Moilanen E. Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3. Scand J Rheumatol. 2014;43:249-53 pubmed publisher
    b>Resistin is an adipocytokine that has been related to inflammation and insulin resistance...
  47. Yaturu S, Reddy R, Rains J, Jain S. Plasma and urine levels of resistin and adiponectin in chronic kidney disease. Cytokine. 2007;37:1-5 pubmed
    ..Adipocyte hormones, resistin and adiponectin are implicated in insulin resistance and atherosclerosis...
  48. Norata G, Ongari M, Garlaschelli K, Tibolla G, Grigore L, Raselli S, et al. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. J Intern Med. 2007;262:104-12 pubmed
    b>Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans...
  49. Tarkowski A, Bjersing J, Shestakov A, Bokarewa M. Resistin competes with lipopolysaccharide for binding to toll-like receptor 4. J Cell Mol Med. 2010;14:1419-31 pubmed publisher
    ..Lipopolysaccharide (LPS) is the main ligand for TLR4. Here we show that resistin, a cystein-rich protein believed to regulate carbohydrate metabolism, competes with LPS for binding to TLR4...
  50. Nogueiras R, Novelle M, Vazquez M, Lopez M, Dieguez C. Resistin: regulation of food intake, glucose homeostasis and lipid metabolism. Endocr Dev. 2010;17:175-84 pubmed publisher
    b>Resistin has been identified as a hormone secreted by adipocytes that is under hormonal and nutritional control. This hormone has been suggested to be the link between obesity and type 2 diabetes...
  51. Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, et al. A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population. PLoS ONE. 2010;5:e9718 pubmed publisher
    Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice...
  52. Pirvulescu M, Manduteanu I, Gan A, Stan D, Simion V, Butoi E, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Commun. 2012;422:321-6 pubmed publisher
    b>Resistin is a significant local and systemic regulatory cytokine involved in inflammation...
  53. Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, et al. PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. Clin Endocrinol (Oxf). 2009;71:341-5 pubmed publisher
    ..b>Resistin, secreted from adipocytes, causes insulin resistance in rodents...
  54. Fargnoli J, Sun Q, Olenczuk D, Qi L, Zhu Y, Hu F, et al. Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function. Eur J Endocrinol. 2010;162:281-8 pubmed publisher
    Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance...
  55. Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12 pubmed
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  56. Burnett M, Lee C, Kinnaird T, Stabile E, Durrani S, Dullum M, et al. The potential role of resistin in atherogenesis. Atherosclerosis. 2005;182:241-8 pubmed
    b>Resistin, an adipocyte-derived cytokine linked to insulin resistance and obesity, has recently been shown to activate endothelial cells (ECs)...
  57. Luo Z, Zhang Y, Li F, He J, Ding H, Yan L, et al. Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells. Endocrine. 2009;36:60-9 pubmed publisher
    b>Resistin is a 12.5-KDa cysteine-rich peptide that has been implicated in the impairment of glucose homeostasis via the AMP-activated protein kinase (AMPK) pathway in a rodent model...
  58. Adeghate E. An update on the biology and physiology of resistin. Cell Mol Life Sci. 2004;61:2485-96 pubmed
    b>Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function...
  59. Ellington A, Malik A, Klee G, Turner S, Rule A, Mosley T, et al. Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. Hypertension. 2007;50:708-14 pubmed
    b>Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction...
  60. Hsu W, Chao Y, Tsai Y, Lien C, Chang C, Deng M, et al. Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol. 2011;226:2181-8 pubmed publisher
    b>Resistin, firstly reported as an adipocyte-specific hormone, is suggested to be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes...
  61. Menzaghi C, Bacci S, Salvemini L, Mendonca C, Palladino G, Fontana A, et al. Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes. PLoS ONE. 2014;8:e64729 pubmed publisher
    High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes...
  62. Lewandowski K, Szosland K, O Callaghan C, Tan B, Randeva H, Lewinski A. Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices. Mol Genet Metab. 2005;85:61-9 pubmed
    ..b>Resistin, an adipocytokine, may represent a link between obesity, and these metabolic disorders...
  63. Hivert M, Manning A, McAteer J, Dupuis J, Fox C, Cupples L, et al. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. Diabetes. 2009;58:750-6 pubmed publisher
    The RETN gene encodes the adipokine resistin. Associations of RETN with plasma resistin levels, type 2 diabetes, and related metabolic traits have been inconsistent...
  64. Qatanani M, Szwergold N, Greaves D, Ahima R, Lazar M. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest. 2009;119:531-9 pubmed publisher
    b>Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting...
  65. Kubota T, Kawano S, Chih D, Hisatake Y, Chumakov A, Taguchi H, et al. Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice. Blood. 2000;96:3953-7 pubmed
    ..Several novel genes were identified that were differentially expressed in normal myelomonocytic cells. Taken together, we have found several genes whose expression might be enhanced by C/EBP epsilon. (Blood. 2000;96:3953-3957) ..
  66. Conneely K, Silander K, Scott L, Mohlke K, Lazaridis K, Valle T, et al. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia. 2004;47:1782-8 pubmed
    b>Resistin is a peptide hormone produced by adipocytes that is present at high levels in sera of obese mice and may be involved in glucose homeostasis through regulation of insulin sensitivity...
  67. Tokuyama Y, Osawa H, Ishizuka T, Onuma H, Matsui K, Egashira T, et al. Serum resistin level is associated with insulin sensitivity in Japanese patients with type 2 diabetes mellitus. Metabolism. 2007;56:693-8 pubmed
    ..To examine which variables influence insulin sensitivity, we compared metabolic parameters, serum resistin, leptin, and adiponectin concentrations to the insulin sensitivity, obtained by frequently sampled intravenous ..
  68. Tang N, Wang L, Yang L, Zhou B, Gu H, Sun Q, et al. A polymorphism in the resistin gene promoter is related to increased C-reactive protein levels in patients with coronary artery disease. Clin Chem Lab Med. 2007;45:1471-5 pubmed
    b>Resistin, a novel adipocyte-derived peptide, has been linked to inflammatory process and coronary artery disease (CAD)...
  69. Wang H, Chen D, Cao J, He Z, Zhu B, Long M. High serum resistin level may be an indicator of the severity of coronary disease in acute coronary syndrome. Chin Med Sci J. 2009;24:161-6 pubmed
    To investigate the correlation between serum resistin level, cardiovascular risk factors and severity of coronary disease in acute coronary syndrome (ACS)...
  70. Hussain S, Asghar M, Javed Q. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Transl Res. 2010;155:142-7 pubmed publisher
    b>Resistin, a novel cytokine, is associated with an inflammatory process and is suggested to induce hypertrophy in rat cardiomyocytes. Resistin gene expression has not been investigated in patients with hypertrophic cardiomyopathy (HCM)...
  71. Devanoorkar A, Dwarakanath C, Gundanavar G, Kathariya R, Patil S. Evaluation of serum resistin levels in periodontal health and disease and effects of non surgical periodontal therapy on its levels. Dis Markers. 2012;32:289-94 pubmed
    b>Resistin and adiponectin are the adipokines secreted by adipocytes and various inflammatory cells. These adipokines are known to play an important role in insulin resistance...
  72. McTernan C, McTernan P, Harte A, Levick P, Barnett A, Kumar S. Resistin, central obesity, and type 2 diabetes. Lancet. 2002;359:46-7 pubmed
    b>Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots...
  73. Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, et al. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun. 2004;314:415-9 pubmed
    b>Resistin is an adipocytokine which plays a role in the development of insulin resistance. In this study, we investigated the direct effect of resistin on vascular endothelial cells...
  74. Chumakov A, Kubota T, Walter S, Koeffler H. Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family. Oncogene. 2004;23:3414-25 pubmed
    ..mXCP1 belongs to a family of XCP/FIZZ/Resistin genes, which includes four murine genes and two human genes, hXCP1 and hXCP2...
  75. Azuma K, Oguchi S, Matsubara Y, Mamizuka T, Murata M, Kikuchi H, et al. Novel resistin promoter polymorphisms: association with serum resistin level in Japanese obese individuals. Horm Metab Res. 2004;36:564-70 pubmed
    b>Resistin, an adipocyte-secreted cytokine recently discovered in mice, has been proposed as a link between obesity and diabetes...
  76. Gerber M, Boettner A, Seidel B, Lammert A, Bar J, Schuster E, et al. Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. J Clin Endocrinol Metab. 2005;90:4503-9 pubmed
    It was hypothesized that resistin links obesity with diabetes, but this has not been studied in children and adolescents to date. We determined serum resistin levels of 135 obese (body mass index, 32.0 +/- 6.2 kg/m2; age, 12.6 +/- 3...
  77. Silswal N, Singh A, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham N. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun. 2005;334:1092-101 pubmed
    b>Resistin, a recently discovered 92 amino acid protein involved in the development of insulin resistance, has been associated with obesity and type 2 diabetes...
  78. Tsukahara T, Nakashima E, Watarai A, Hamada Y, Naruse K, Kamiya H, et al. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2009;84:179-86 pubmed publisher
    b>Resistin, which appears to be related to insulin resistance, is secreted mainly from macrophages in human and some of its polymorphisms have been reported...
  79. Silha J, Krsek M, Skrha J, Sucharda P, Nyomba B, Murphy L. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003;149:331-5 pubmed
    Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin...
  80. Norata G, Ongari M, Garlaschelli K, Raselli S, Grigore L, Catapano A. Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur J Endocrinol. 2007;156:279-84 pubmed
    The role of resistin in insulin sensitivity and obesity is controversial...
  81. Osawa H, Doi Y, Makino H, Ninomiya T, Yonemoto K, Kawamura R, et al. Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study. Cardiovasc Diabetol. 2009;8:60 pubmed publisher
    b>Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic stroke is limited...
  82. Wang H, Chu W, Hemphill C, Elbein S. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002;87:2520-4 pubmed
    ..Recently, a new adipocyte hormone, resistin, was identified, shown to reduce insulin-mediated glucose uptake, and shown to be increased in obese mice...
  83. Urbanek M, Du Y, Silander K, Collins F, Steppan C, Strauss J, et al. Variation in resistin gene promoter not associated with polycystic ovary syndrome. Diabetes. 2003;52:214-7 pubmed
    ..A promising candidate gene for PCOS, resistin, maps to exactly this region...
  84. Mattevi V, Zembrzuski V, Hutz M. A resistin gene polymorphism is associated with body mass index in women. Hum Genet. 2004;115:208-12 pubmed
    The potential association of resistin (RETN) gene variability with obesity-related phenotypes was investigated in 585 non-diabetic individuals of European descent...
  85. Curat C, Wegner V, Sengenes C, Miranville A, Tonus C, Busse R, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744-7 pubmed
    ..of chemokines (monocyte chemotactic protein 1, macrophage inflammatory protein 1alpha, IL-8) and the adipokines resistin and visfatin than did mature adipocytes, as assessed by real-time PCR analysis...
  86. Langheim S, Dreas L, Veschini L, Maisano F, Foglieni C, Ferrarello S, et al. Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome. Am J Physiol Heart Circ Physiol. 2010;298:H746-53 pubmed publisher
    ..EAT of ACS patients showed significantly higher gene expression and protein secretion of resistin than patients with stable CAD...
  87. Windham B, Griswold M, Farasat S, Ling S, Carlson O, Egan J, et al. Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens. 2010;23:501-7 pubmed publisher
    ..the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness...
  88. Tsioufis C, Dimitriadis K, Selima M, Miliou A, Toutouzas K, Roussos D, et al. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Am J Hypertens. 2010;23:681-6 pubmed publisher
    Evidence suggests that resistin, a recently described protein, is associated with subclinical atherosclerosis in different clinical settings...
  89. Nozue H, Imai H, Saitoh H, Aoki T, Ichikawa K, Kamoda T. Serum resistin concentrations in children with Kawasaki disease. Inflamm Res. 2010;59:915-20 pubmed publisher
    Human resistin is expressed strongly in monocytes or macrophages rather than in adipocytes and may play a pivotal role in inflammation...
  90. Steppan C, Brown E, Wright C, Bhat S, Banerjee R, Dai C, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A. 2001;98:502-6 pubmed
    We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells...
  91. Seo J, Noh M, Yoo E, Park S, Park J, Lee I, et al. Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Mol Endocrinol. 2003;17:1522-33 pubmed
    Recent studies with murine models propose that resistin would be a possible mediator to link between obesity and insulin resistance...
  92. Chen B, Song Y, Ding E, Roberts C, Manson J, Rifai N, et al. Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts. Diabetes Care. 2009;32:329-34 pubmed publisher
    The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women...