Gene Symbol: renin
Description: renin
Alias: HNFJ2, renin, angiotensin-forming enzyme, angiotensinogenase, renin precursor, renal
Species: human
Products:     renin

Top Publications

  1. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-27 pubmed
    b>Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors...
  2. Fuchs S, Philippe J, Germain S, Mathieu F, Jeunemaitre X, Corvol P, et al. Functionality of two new polymorphisms in the human renin gene enhancer region. J Hypertens. 2002;20:2391-8 pubmed
    The production of renin, which catalyses the rate-limiting step of the renin-angiotensin system, is strongly stimulated by a 225 bp enhancer element in the distal region of the promoter of the human gene (-5777 to -5552)...
  3. Mansego M, Redon J, Marin R, Gonzalez Albert V, Martin Escudero J, Fabia M, et al. Renin polymorphisms and haplotypes are associated with blood pressure levels and hypertension risk in postmenopausal women. J Hypertens. 2008;26:230-7 pubmed publisher
    b>Renin is a key protein of the renin-angiotensin system involved in the physiological control of blood pressure; the renin gene is therefore a candidate for essential hypertension in humans...
  4. Sun B, Williams J, Pojoga L, Chamarthi B, Lasky Su J, Raby B, et al. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011;12:564-71 pubmed publisher
    The renin gene has been previously reported to be associated with essential hypertension in a variety of ethnic groups...
  5. Zhu X, Chang Y, Yan D, Weder A, Cooper R, Luke A, et al. Associations between hypertension and genes in the renin-angiotensin system. Hypertension. 2003;41:1027-34 pubmed
    The genes of the renin-angiotensin system have been subjected to intense molecular scrutiny in cardiovascular disease studies, but their contribution to risk is still uncertain...
  6. Moore N, Dicker P, O Brien J, Stojanovic M, Conroy R, Treumann A, et al. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. Hypertension. 2007;50:340-7 pubmed
    b>Renin catalyzes the rate-limiting step of the renin-angiotensin system. A T allele variant at position -5312 within a distal enhancer region has been reported to increase in vitro renin gene transcription...
  7. Niu W, Qi Y, Guo S, Gao P, Zhu D. Association of renin BglI polymphism with essential hypertension: a meta-analysis involving 1811 cases and 1626 controls. Clin Exp Hypertens. 2010;32:431-8 pubmed publisher
    In an effort to clarify association of an intronic polymorphism BglI in a renin gene with essential hypertension, we performed a meta-analysis of the case-control association studies...
  8. Fu Y, Katsuya T, Asai T, Fukuda M, Inamoto N, Iwashima Y, et al. Lack of correlation between Mbo I restriction fragment length polymorphism of renin gene and essential hypertension in Japanese. Hypertens Res. 2001;24:295-8 pubmed
    Predisposition to essential hypertension is associated with gene polymorphisms of the renin angiotensin system (RAS)...
  9. Adams D, Beveridge D, van der Weyden L, Mangs H, Leedman P, Morris B. HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. J Biol Chem. 2003;278:44894-903 pubmed
    Production of renin is critically dependent on modulation of REN mRNA stability. Here we sought to elucidate the molecular mechanisms involved...

More Information

Publications123 found, 100 shown here

  1. Itani H, Liu X, Pratt J, Sigmund C. Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology. 2007;148:1424-30 pubmed
    The renin gene is regulated by an enhancer located 2.6 kb upstream of the transcription start site in the mouse and 11 kb upstream in humans...
  2. Konoshita T, Fuchs S, Makino Y, Wakahara S, Miyamori I. A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene. J Cell Biochem. 2007;102:1043-50 pubmed
    The regulation of renin gene expression is thought to be fundamental to regulation of the total renin-angiotensin system...
  3. Qi Y, Niu W, Cen W, Cui C, Zhuoma C, Zhuang L, et al. Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations. J Hum Hypertens. 2007;21:907-10 pubmed
  4. Ying C, Wang Y, Wu Z, Fang M, Wang J, Li Y, et al. Association of the renin gene polymorphism, three angiotensinogen gene polymorphisms and the haplotypes with essential hypertension in the Mongolian population. Clin Exp Hypertens. 2010;32:293-300 pubmed publisher
    b>Renin is a rate-limiting enzyme of the renin-angiotensin system and plays a crucial role in the regulation of blood pressure (BP)...
  5. Konoshita T, Makino Y, Wakahara S, Ido K, Yoshida M, Kawai Y, et al. Candidate cis-elements for human renin gene expression in the promoter region. J Cell Biochem. 2004;93:327-36 pubmed
    The regulation of renin gene expression, the rate-limiting enzyme of the system, is thought to be fundamental to the total system...
  6. Tanimoto K, Sugiura A, Kanafusa S, Saito T, Masui N, Yanai K, et al. A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation. J Clin Invest. 2008;118:1006-16 pubmed publisher
    b>Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in regulating blood pressure and electrolyte homeostasis and is predominantly expressed in the kidney...
  7. Mohana Vamsi U, Swapna N, Usha G, Vishnupriya S, Padma T. Contribution of REN gene MBbo I polymorphism in conferring risk for essential hypertension: a case control study from South India. J Renin Angiotensin Aldosterone Syst. 2013;14:242-7 pubmed publisher
    b>Renin is a rate-limiting enzyme of the renin-angiotensin-aldosterone system (RAAS) that plays a crucial role in the regulation of blood pressure...
  8. Biswas N, Maihofer A, Mir S, Rao F, Zhang K, Khandrika S, et al. Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system. BMC Med Genet. 2016;17:21 pubmed publisher KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte ..
  9. Milsted A, Underwood A, Dunmire J, DelPuerto H, Martins A, Ely D, et al. Regulation of multiple renin-angiotensin system genes by Sry. J Hypertens. 2010;28:59-64 pubmed publisher
    ..The objective of this study was to determine whether renin-angiotensin system genes participate in Sry-mediated effects...
  10. Araújo F, Milsted A, Watanabe I, Del Puerto H, Santos R, Lazar J, et al. Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. Physiol Genomics. 2015;47:177-86 pubmed publisher
    The renin-angiotensin system (RAS) is subject to sex-specific modulation by hormones and gene products...
  11. Angelidis G, Samara M, Papathanassiou M, Satra M, Valotassiou V, Tsougos I, et al. Impact of renin-angiotensin-aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters. J Nucl Cardiol. 2018;: pubmed publisher
    b>Renin-angiotensin-aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion...
  12. Zhu H, Wang Z, Dong Z, Wang C, Cao Q, Fan F, et al. Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. Biochim Biophys Acta Mol Basis Dis. 2018;: pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic regulation of aging and longevity edited by Jun Ren & Megan Yingmei Zhang. ..
  13. Fang Y, Zhong R, Sun X, Zhou D. High salt diet decreases reproductive performance in rams and down-regulates gene expression of some components of the renin-angiotensin system in the testis. Theriogenology. 2018;107:127-133 pubmed publisher
    ..concentrations of metabolic (leptin and insulin) and sex (T, FSH and LH) hormones, but did not affect the plasma renin-angiotensin system (RAS) component (REN, Ang II, ACE and ALD)...
  14. Farooqi Z, Tareen S, Ahmed J, Zaidi N. Logical Analysis of Regulation of Interleukin-12 Expression Pathway Regulation During HCV Infection. Protein Pept Lett. 2016;23:581-9 pubmed
    ..It also implicated that human immune system tries to clear HCV but core is capable of inducing system oscillations to evade the immunity. ..
  15. Alshudukhi A, Zhu J, Huang D, Jama A, Smith J, Wang Q, et al. Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. FASEB J. 2018;:fj201800374 pubmed publisher
    ..Alshudukhi, A. A., Zhu, J., Huang, D., Jama, A., Smith, J. D., Wang, Q. J., Esser, K. A., Ren, H. Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. ..
  16. Vaneckova I, Hojna S, Kadlecová M, Vernerova Z, Kopkan L, Cervenka L, et al. Renoprotective effects of ET(A) receptor antagonists therapy in experimental non-diabetic chronic kidney disease: Is there still hope for the future?. Physiol Res. 2018;67:S55-S67 pubmed
    ..demonstrated in adult subtotally nephrectomized Ren-2 transgenic rats that the addition of a diuretic on top of renin-angiotensin and ET(A) blockade led to a further decrease of proteinuria...
  17. Sato K, Tsuji A, Usumoto Y, Kudo K, Yokoyama T, Ikeda N. Expression of mRNA in the frontal cortex and hypothalamus in a rat model of acute carbon dioxide poisoning. Leg Med (Tokyo). 2016;19:101-6 pubmed publisher
    ..Th), heat shock protein beta 2 (Hspb2), and opioid receptor delta 1 (Oprd1) expressed in the frontal cortex and renin (Ren), pancreatic polypeptide (Ppy), corticotropin releasing hormone receptor 2 (Crhr2), carbonic anhydrase 1 (..
  18. Haznedaroglu I, Malkan U. Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies. Eur Rev Med Pharmacol Sci. 2016;20:4089-4111 pubmed
    The existence of a local renin-angiotensin system (RAS) specific to the hematopoietic bone marrow (BM) microenvironment had been proposed two decades ago...
  19. Tang A, Ji M, Zhang Y, Zou J, Li M, Yang L, et al. Dietary Behaviors and Caregiver Perceptions of Overweight and Obesity among Chinese Preschool Children. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..Interventions to improve awareness of child overweight should be coupled with efforts that teach caregivers about healthy weight management strategies. ..
  20. Li Y, Tan Y, Cai H, Zhang J. Metabonomic study of the fruits of Alpinia oxyphylla as an effective treatment for chronic renal injury in rats. J Pharm Biomed Anal. 2016;124:236-245 pubmed publisher
    ..05 or 0.01), These findings may be promising to yield a valuable insight into the pathophysiology of CKD and serve as characteristics to explain the mechanisms of AOE. ..
  21. Zhang Y, Wang C, Zhou J, Sun A, Hueckstaedt L, Ge J, et al. Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1919-1932 pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang. ..
  22. Chen X, Ling Y, Wei Y, Tang J, Ren Y, Zhang B, et al. Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice. FASEB J. 2018;: pubmed publisher
    ..Wei, Y., Tang, J., Ren, Y., Zhang, B., Jiang, F., Li, H., Wang, R., Wen, W., Lv, G., Wu, M., Chen, L., Li, L., Wang, H. Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice. ..
  23. Li T, Yu Y, Tsai F, Cheng C, Wu Y, Ho T, et al. Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. J Ethnopharmacol. 2018;213:92-100 pubmed publisher
  24. Tomaszewski M, Eales J, Denniff M, Myers S, Chew G, Nelson C, et al. Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure. J Am Soc Nephrol. 2015;26:3151-60 pubmed publisher
    ..genetic control and that renal expression of several FGF1 partner genes involved in the natriuretic peptide catabolism pathway, renin-angiotensin cascade, and sodium handling network may explain the association between FGF1 and BP.
  25. Hsu C, Lin Y, Lu P, Tain Y. Early Supplementation of d-Cysteine or l-Cysteine Prevents Hypertension and Kidney Damage in Spontaneously Hypertensive Rats Exposed to High-Salt Intake. Mol Nutr Food Res. 2018;62: pubmed publisher
    ..hypertension becomes evident and may protect against hypertension and kidney damage in adult SHRs exposed to high salt consumption via regulation of oxidative stress, renin-angiotensin system, and H2 S-generating pathways.
  26. Jia G, Jia Y, Sowers J. Role of mineralocorticoid receptor activation in cardiac diastolic dysfunction. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2012-2018 pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure edited by Dr. Jun Ren & Yingmei Zhang. ..
  27. Song H, Yan C, Tian X, Zhu N, Li Y, Liu D, et al. CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1893-1903 pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren and Megan Yingmei Zhang. ..
  28. Chen H, Lin Y, Chen Y. Identifying Chinese herbal medicine network for treating acne: Implications from a nationwide database. J Ethnopharmacol. 2016;179:1-8 pubmed publisher
    ..These results may be beneficial for further bench or clinical studies when choosing target CHM. ..
  29. Soubrier F, Panthier J, Corvol P, Rougeon F. Molecular cloning and nucleotide sequence of a human renin cDNA fragment. Nucleic Acids Res. 1983;11:7181-90 pubmed
    We have studied human renin messenger RNA by hybridization with the mouse submaxillary gland (SMG) renin cDNA probe. The human kidney messenger RNA is about 1.6 kilobase (kb) long, similarly to the mouse SMG renin mRNA...
  30. Radi Z, Murad Y. Cellular expression of renal, cardiac and pulmonary inducible nitric oxide synthase in double-transgenic mice expressing human renin and angiotensinogen genes. Clin Exp Pharmacol Physiol. 2009;36:571-5 pubmed publisher
    1. Hypertensive mice expressing the human renin (REN) and angiotensinogen (AGT) genes are used as a model for human hypertension. 2...
  31. Gao J, Shih C, Kopeć K, Krzemiński W, Ren D. New species and revisions of Pediciidae (Diptera) from the Middle Jurassic of northeastern China and Russia. Zootaxa. 2015;3963:240-9 pubmed publisher
    ..We also suggest treating Praearchitipula lata Kalugina, 1985 as a junior synonym of Praearchitipula notabilis Kalugina, 1985. An emended generic diagnosis of Praearchitipula is provided. ..
  32. Hudson R, Dawson J, Chong P, Yang Z, Millen L, Thomas P, et al. Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface. Mol Pharmacol. 2017;92:124-135 pubmed publisher
    ..2012; Ren et al., 2013), this additional mode of VX-809 binding provides insight into conformational dynamics and allostery within CFTR. ..
  33. Li S, Dong Y, Wang K, Wang Z, Zhang X. Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways. J Orthop Surg Res. 2017;12:168 pubmed publisher
    ..KEGG enrichment analysis indicated upregulated DEGs were involved in Renin-angiotensin system (e.g., Agt, angiotensinogen) and Wnt signaling pathway (e.g...
  34. Evin G, Galen F, Carlson W, Handschumacher M, Novotny J, Bouhnik J, et al. Characterization of five epitopes of human renin from a computer model. Biochemistry. 1988;27:156-64 pubmed
    ..To predict epitopes of human renin, a computer algorithm was used to calculate the accessibility of a model of the three-dimensional structure of ..
  35. Kosachunhanun N, Hunt S, Hopkins P, Williams R, Jeunemaitre X, Corvol P, et al. Genetic determinants of nonmodulating hypertension. Hypertension. 2003;42:901-8 pubmed
    We sought to determine whether genes of the renin-angiotensin-aldosterone system can predict the nonmodulating intermediate phenotype in essential hypertension...
  36. Zivná M, Hulkova H, Matignon M, Hodanova K, Vylet al P, Kalbacova M, et al. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet. 2009;85:204-13 pubmed publisher
    ..Leu16del) or the amino acid exchange (p.Leu16Arg) of a single leucine residue in the signal sequence of renin. Both mutations decrease signal sequence hydrophobicity and are predicted by bioinformatic analyses to damage ..
  37. Ljungberg L, Ostgren C, Nystrom F, Länne T. Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients. J Renin Angiotensin Aldosterone Syst. 2014;15:61-8 pubmed publisher
    ..The renin-angiotensin system (RAS) plays a central role in regulation of blood pressure (BP)...
  38. Christophe V, Duprez C, Congard A, Antoine P, Lesur A, Fournier E, et al. The subjective experience of young women with non-metastatic breast cancer: the Young Women with Breast Cancer Inventory. Health Qual Life Outcomes. 2015;13:73 pubmed publisher
    ..This scale may improve the medical, psychological and social care of breast cancer patients. ..
  39. Makino Y, Konoshita T, Omori A, Maegawa N, Nakaya T, Ichikawa M, et al. A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression. PLoS ONE. 2015;10:e0137469 pubmed publisher
    The high heritability of plasma renin activity was confirmed in recent investigations...
  40. Tang Y, Zhang Z, Chen S, Chen S, Li C, Chen J, et al. Effect of topical propranolol gel on plasma renin, angiotensin II and vascular endothelial growth factor in superficial infantile hemangiomas. J Huazhong Univ Sci Technolog Med Sci. 2015;35:759-762 pubmed publisher
    The effect of topical propranolol gel on the levels of plasma renin, angiotensin II (ATII) and vascular endothelial growth factor (VEGF) in superficial infantile hemangiomas (IHs) was investigated...
  41. Li M, Ren H, Sheth K, Shi F, Liu Q. A TSPO ligand attenuates brain injury after intracerebral hemorrhage. FASEB J. 2017;31:3278-3287 pubmed publisher
    ..TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K. N., Shi, F.-D., Liu, Q. A TSPO ligand attenuates brain injury after intracerebral hemorrhage. ..
  42. Thompson J, Sebire S, Kesten J, Zahra J, Edwards M, Solomon Moore E, et al. How parents perceive screen viewing in their 5-6 year old child within the context of their own screen viewing time: a mixed-methods study. BMC Public Health. 2017;17:471 pubmed publisher
    ..Designing interventions aimed to create environments that are less supportive of SV, with more structured approaches to SV parenting strategies are warranted. ..
  43. Sunder Plassmann G, Kittler H, Eberle C, Hirschl M, Woisetschläger C, Derhaschnig U, et al. Angiotensin converting enzyme DD genotype is associated with hypertensive crisis. Crit Care Med. 2002;30:2236-41 pubmed
    ..We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis. Population-based case-control study...
  44. Fuchs S, Philippe J, Corvol P, Pinet F. Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium. J Hypertens. 2003;21:327-35 pubmed
    The production of renin, which catalyzes the rate-limiting step of the renin-angiotensin system, is tightly regulated by intracellular second messengers. Among them, an increase of intracellular calcium represses renin gene expression...
  45. Lamounier Zepter V, Rotthoff T, Ansurudeen I, Kopprasch S, Scherbaum W, Ehrhart Bornstein M, et al. Increased aldosterone/renin quotient in obese hypertensive women: a novel role for low-density lipoproteins?. Horm Metab Res. 2006;38:471-5 pubmed
    ..Involvement of renin-independent mechanisms has been suggested in adrenal stimulation of aldosterone secretion in obese patients...
  46. Zhou X, Davis D, Sigmund C. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. J Biol Chem. 2006;281:35296-304 pubmed
    b>Renin is the rate-limiting enzyme in the renin-angiotensin system and thus dictates the level of the pressor hormone angiotensin-II...
  47. Zhou A, Carrell R, Murphy M, Wei Z, Yan Y, Stanley P, et al. A redox switch in angiotensinogen modulates angiotensin release. Nature. 2010;468:108-11 pubmed publisher critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors...
  48. Lumbers E, Pringle K, Wang Y, Gibson K. The renin-angiotensin system from conception to old age: the good, the bad and the ugly. Clin Exp Pharmacol Physiol. 2013;40:743-52 pubmed publisher
    The renin-angiotensin system (RAS) plays a critical role in placentation and nephrogenesis...
  49. Iwata Y. Assessment of clasp design and flexural properties of acrylic denture base materials for use in non-metal clasp dentures. J Prosthodont Res. 2016;60:114-22 pubmed publisher
  50. Ren R, Zhang Y, Nadappuram B, Akpinar B, Klenerman D, Ivanov A, et al. Nanopore extended field-effect transistor for selective single-molecule biosensing. Nat Commun. 2017;8:586 pubmed publisher
    ..Ren et al. combine a nanopore sensor and a field-effect transistor, whereby gate voltage mediates DNA and protein transport through the nanopore. ..
  51. Benjannet S, Reudelhuber T, Mercure C, Rondeau N, Chretien M, Seidah N. Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1. J Biol Chem. 1992;267:11417-23 pubmed
    ..Using human prorenin as a model, we show that PC1 can process it to active renin in cells containing secretory granules, such as the somatomammotroph cell line GH4, but not in cells which lack ..
  52. Hori H, Yoshino T, Ishizuka Y, Yamauchi T, Shiratori Y, Nakagawa S, et al. Characterization of N-linked oligosaccharides attached to human renin expressed in COS cells. Clin Exp Hypertens A. 1988;10:1147-55 pubmed
    To study the role of N-linked oligosaccharides attached to human renin, we generated three kinds of glycosylation-deficient renins in which one or both of two putative N-glycosylation sites was eliminated by amino acid replacement using ..
  53. Haas E, Goldblatt H. Kinetic constants of the human renin and human angiotensinogen reaction. Circ Res. 1967;20:45-55 pubmed
  54. Valdez Velazquez L, Quintero Ramos A, Perez S, Mendoza Carrera F, Montoya Fuentes H, Olivares N, et al. Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes. J Renin Angiotensin Aldosterone Syst. 2007;8:160-8 pubmed publisher
    ..Although several markers related to the renin-angiotensin system (RAS) have been evaluated in certain pregnancy complications, only the angiotensin-converting ..
  55. Ichihara A, Sakoda M, Mito Kurauchi A, Itoh H. Activated prorenin as a therapeutic target for diabetic nephropathy. Diabetes Res Clin Pract. 2008;82 Suppl 1:S63-6 pubmed publisher
    ..Pro)renin receptors were recently found in the human kidney, and their distribution in the kidneys include the mesangium and ..
  56. Arias L, Bruneval P, Blanco J. Renin expression in adult renal epithelial tumors with granular cells. Pathol Res Pract. 2010;206:731-4 pubmed publisher
    Renal cell tumors have been shown to be associated with secretory products, including renin, but the frequency of renin expression is not known...
  57. Mital S, Chung W, Colan S, Sleeper L, Manlhiot C, Arrington C, et al. Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation. 2011;123:2353-62 pubmed publisher
    We investigated the effect of polymorphisms in the renin-angiotensin-aldosterone system (RAAS) genes on ventricular remodeling, growth, renal function, and response to enalapril in infants with single ventricle...
  58. Deng Y, Aluko R, Jin Q, Zhang Y, Yuan L. Inhibitory activities of baicalin against renin and angiotensin-converting enzyme. Pharm Biol. 2012;50:401-6 pubmed publisher
    ..To investigate the inhibitory activities of baicalin against renin and angiotensin-I converting enzyme (ACE) and their molecule mechanism of interactions...
  59. Ren X, Feng Y, Guo J, Wang H, Li Q, Yang J, et al. Correction: Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications. Chem Soc Rev. 2015;44:5745 pubmed publisher
    ..Correction for 'Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications' by Xiangkui Ren et al., Chem. Soc. Rev., 2015, DOI: . ..
  60. Li J, Ren B, Li A. Study of the genus Gomphocerippus (Orthoptera, Acridoidea, Acrididae, Gomphocerinae) with a new species from northeast China. Zootaxa. 2016;4072:585-8 pubmed publisher
    ..2 times cubital area in width. The type specimens are deposited in the Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, Northeast Normal University, Changchun, Jilin, China. ..
  61. Qu Y, Zou Z. Non-sky polarization-based dehazing algorithm for non-specular objects using polarization difference and global scene feature. Opt Express. 2017;25:25004-25022 pubmed publisher
  62. Fabris B, Bortoletto M, Candido R, Barbone F, Cattin M, Calci M, et al. Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension. J Hypertens. 2005;23:309-16 pubmed
    The renin-angiotensin-aldosterone system (RAAS) plays an important role in the control of renal function both in physiological and pathological conditions...
  63. Chikhladze N, Samedova K, Sudomoina M, Thant M, Htut Z, Litonova G, et al. [Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. Kardiologiia. 2008;48:37-42 pubmed
    We carried out comparison of distribution of alleles and genotypes of polymorphic loci of renin-angiotensin-aldosterone system genes: CYP11B2 (C-344T), AGT (Thr174Met) and REN (C-5434T, C-5312T, and A BglI G) and their combinations in ..
  64. Vefring H, Wee L, Jugessur A, Gjessing H, Nilsen S, Lie R. Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data. BMC Med Genet. 2010;11:90 pubmed publisher
    ..Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in hypertension...
  65. Yokota H, Nagaoka T, Tani T, Takahashi A, Sato E, Kato Y, et al. Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes. J Renin Angiotensin Aldosterone Syst. 2011;12:290-4 pubmed publisher
    ..However, there was no difference in the development of DR between high and low groups in females (p = 0.58). Serum prorenin levels in males with type 2 diabetes could be a new prognostic indicator of the development of DR. ..
  66. Wang H, Cai J. The role of microRNAs in heart failure. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2019-2030 pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang. ..
  67. Zheng F, Shi J, Dang Y. A new species of the genus <i>Mongolotettix</i> Rehn, 1928 from Hubei, China (Acrididae, Acridoidea, Orthoptera). Zootaxa. 2017;4250:198-200 pubmed publisher
    ..In the present paper, we describe a new species of the genus from Hubei, China. Type specimens are deposited in the College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China. ..
  68. Kobayashi Y, Sugioka Y, Ito T. ERP Responses to Violations in the Hierarchical Structure of Functional Categories in Japanese Verb Conjugation. J Psycholinguist Res. 2018;47:215-240 pubmed publisher
  69. Uehara S, Tsuchida M, Kanno T, Sasaki M, Nishikibe M, Fukamizu A. Late-onset obesity in mice transgenic for the human renin gene. Int J Mol Med. 2003;11:723-7 pubmed
    We previously generated a strain of transgenic mice carrying the human renin gene, hRN8-12, in the background of C57BL/6j...
  70. Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, et al. Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes. Stroke. 2009;40:597-603 pubmed publisher
    We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes...
  71. Min H, Maruyama H, Jang B, Shimada M, Mirshahi F, Ren S, et al. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. FASEB J. 2016;30:4071-4082 pubmed
    ..Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. ..
  72. Hobart P, Fogliano M, O Connor B, Schaefer I, Chirgwin J. Human renin gene: structure and sequence analysis. Proc Natl Acad Sci U S A. 1984;81:5026-30 pubmed
    The complete protein precursor of human kidney renin has been determined from the sequence of cloned genomic DNA. The gene spans 12 kilobases of DNA and is interrupted by eight intervening sequences...
  73. Lee Kirsch M, Gaudet F, Cardoso M, Lindpaintner K. Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res. 1999;84:240-6 pubmed
    The aspartyl protease renin catalyzes the initial and rate-limiting step in the formation of the biologically active peptide angiotensin II...
  74. El Migdadi F. A comparative study of plasma renin activity, aldosterone and atrial natriuretic hormone between normotensive and hypertensive people living at below sea level altitude (Jordan Valley) and those residing at moderate altitude above. Neuro Endocrinol Lett. 2007;28:386-94 pubmed
    A cross-sectional study was designed to investigate the association of the levels of plasma renin activity (PRA) and aldosterone (ALDO) and atrial natriuretic hormone (ANH) with the rates of hypertension prevalence in people living at ..
  75. Gruson D, Maisin D, Lison P, Maiter D, Persu A. Two-site automated chemiluminescent assay for measurement of immunoreactive renin. Biomarkers. 2011;16:605-9 pubmed publisher
    Measurement of renin is important for the clinical assessment of hypertensive patients and for the screening for primary aldosteronism...
  76. Yoshida S, Ishizawa K, Ayuzawa N, Ueda K, Takeuchi M, Kawarazaki W, et al. Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. Clin Exp Nephrol. 2014;18:593-9 pubmed publisher
    The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression...
  77. Do Y, Shinagawa T, Tam H, Inagami T, Hsueh W. Characterization of pure human renal renin. Evidence for a subunit structure. J Biol Chem. 1987;262:1037-43 pubmed
    b>Renin was completely purified from human kidney cortex employing a rapid three-step procedure which included homogenization and ammonium sulfate precipitation, aminohexyl-pepstatin affinity chromatography, and affinity chromatography ..
  78. Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, et al. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet. 2005;37:964-8 pubmed nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1...
  79. Tu W, Eckert G, Pratt J, Jan Danser A. Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentration. Am J Hypertens. 2012;25:1030-4 pubmed publisher
    All renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin-angiotensin-aldosterone activity...
  80. Wolf B, Diop F, Ferraris P, Wichit S, Busso C, Missé D, et al. Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning. Open Biol. 2017;7: pubmed publisher
    ..We conclude that infection with Flaviviridae can increase centrosome numbers and impair spindle positioning, thus potentially contributing to microcephaly in the case of Zika. ..
  81. Iñigo S, Casares M, Jorge C, Leiza S, Santana G, Bravo de Laguna S, et al. Relevance of renin expression by real-time PCR in acute myeloid leukemia. Leuk Lymphoma. 2006;47:409-16 pubmed
    ..Previous research showed that, while normal bone marrow cells lack expression of renin, myeloid blasts have been reported to do so...
  82. Todorov V, Desch M, Schubert T, Kurtz A. The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by peroxisome proliferator-activated receptor-gamma. Endocrinology. 2008;149:4647-57 pubmed publisher
    We recently reported that human renin gene transcription is stimulated by the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma in the renin-producing cell line Calu-6...
  83. Brugts J, De Maat M, Boersma E, Witteman J, van Duijn C, Uitterlinden A, et al. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2009;23:171-81 pubmed publisher
    ..Candidate genes were selected in the renin-angiotensin-system and bradykinin pathways...
  84. Ragia G, Nikolaidis E, Tavridou A, Arvanitidis K, Kanoni S, Dedoussis G, et al. Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients. J Renin Angiotensin Aldosterone Syst. 2010;11:136-45 pubmed publisher
    ..Genetic polymorphisms of renin-angiotensin-aldosterone system (RAAS) components have been associated with CAD...
  85. Manfredi M, Martinotti S, Gosetti F, Ranzato E, Marengo E. The secretome signature of malignant mesothelioma cell lines. J Proteomics. 2016;145:3-10 pubmed publisher
    ..The overall aim was to identify novel tumor-derived protein biomarkers with the potential to be applied for early diagnosis, prognosis, therapy prediction and/or disease monitoring of MMe. ..
  86. Marcisz C, Kucharz E, Marcisz Orzel M, Poreba R, Orzel A, Sioma Markowska U. Changes of poststimulatory plasma renin activity in women with hyperthyroidism or hypothyroidism in relation to therapy. Neuro Endocrinol Lett. 2011;32:301-7 pubmed
    The influence of thyroid hormones upon renin-angiotensin-aldosterone system is poorly understood. Under basal conditions, individuals belong to normal, low or high plasma renin activity (PRA) subjects...
  87. Maeda Y, Hirose H, Inadome Y. Renin production site in the end-stage kidney. Clin Exp Nephrol. 2013;17:439-40 pubmed publisher
  88. Arefi S, Mottaghi S, Sharifi A. Studying the correlation of renin-angiotensin-system (RAS) components and insulin resistance in polycystic ovary syndrome (PCOs). Gynecol Endocrinol. 2013;29:470-3 pubmed publisher
    ..diabetes and obesity are all strongly correlated with PCOS; moreover, the possibility of direct androgen mediated renin-angiotensin system (RAS) stimulation in women with PCOS is also reported...
  89. Lissek S, Glaubitz B, Klass A, Tegenthoff M. The effects of dopaminergic D2-like receptor stimulation upon behavioral and neural correlates of renewal depend on individual context processing propensities. Neuroimage. 2018;169:69-79 pubmed publisher
    ..The findings demonstrate that hippocampal dopamine is important for encoding and providing of context information, and thus crucially involved in the renewal effect. ..
  90. Imai T, Miyazaki H, Hirose S, Hori H, Hayashi T, Kageyama R, et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci U S A. 1983;80:7405-9 pubmed
    The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed from human kidney poly(A)+ RNA by applying the vector/primer method of Okayama and Berg...
  91. Tamura K, Umemura S, Fukamizu A, Ishii M, Murakami K. Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body. Hypertens Res. 1995;18:7-18 pubmed
    The renin-angiotensin system (RAS) plays a key role in the regulation of the circulation and is critically involved in the pathogenesis of several diseases, including hypertension...
  92. Crawford D, Carlson C, Rieder M, Carrington D, Yi Q, Smith J, et al. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet. 2004;74:610-22 pubmed