RELN

Summary

Gene Symbol: RELN
Description: reelin
Alias: ETL7, LIS2, PRO1598, reelin
Species: human
Products:     RELN

Top Publications

  1. Liu Y, Chen P, McGrath J, Wolyniec P, Fallin D, Nestadt G, et al. Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women. Psychiatr Genet. 2010;20:184-6 pubmed publisher
    A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case--control study specifically in women by Shifman et al...
  2. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry. 2008;63:530-3 pubmed
    Hypermethylation of the reelin (RELN) promoter region and the reduced levels of its messenger RNA and protein have been implicated in the pathophysiology of schizophrenia...
  3. Kramer P, Xu H, Woltjer R, Westaway S, Clark D, Erten Lyons D, et al. Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging. 2011;32:2113-22 pubmed publisher
    ..Immunohistochemical data for reelin expression in AD-related brain regions added support for these findings...
  4. Stein T, Cosimo E, Yu X, Smith P, Simon R, Cottrell L, et al. Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis. Am J Pathol. 2010;177:2323-33 pubmed publisher
    b>Reelin is a secreted, signaling protein associated with neuronal cell positioning and migration...
  5. Krstic D, Pfister S, Notter T, Knuesel I. Decisive role of Reelin signaling during early stages of Alzheimer's disease. Neuroscience. 2013;246:108-16 pubmed publisher
    ..In this review we present and discuss novel evidence that the extracellular signaling protein Reelin, expressed along the olfactory and limbic pathways in the adult brain, might hold a key to understand the earliest ..
  6. Chen Y, Sharma R, Costa R, Costa E, Grayson D. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res. 2002;30:2930-9 pubmed
    ..To study mechanisms responsible for this down-regulation, we have analyzed the promoter of the human reelin gene...
  7. Kubo K, Mikoshiba K, Nakajima K. Secreted Reelin molecules form homodimers. Neurosci Res. 2002;43:381-8 pubmed
    ..These precise patterns of neuronal alignment are regulated by an extracellular matrix protein Reelin, and binding of Reelin to its receptors induces tyrosine phosphorylation of the intracellular adaptor protein ..
  8. Weeber E, Beffert U, Jones C, Christian J, Forster E, Sweatt J, et al. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem. 2002;277:39944-52 pubmed
    ..receptors, the very low density lipoprotein (VLDL) receptor and apoE receptor 2 (apoER2), are also receptors for Reelin, a signaling protein that regulates neuronal migration during brain development...
  9. Yasui N, Kitago Y, Beppu A, Kohno T, Morishita S, Gomi H, et al. Functional importance of covalent homodimer of reelin protein linked via its central region. J Biol Chem. 2011;286:35247-56 pubmed publisher
    b>Reelin is a 3461-residue secreted glycoprotein that plays a critical role in brain development through its action on target neurons...

More Information

Publications74

  1. Shifman S, Johannesson M, Bronstein M, Chen S, Collier D, Craddock N, et al. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet. 2008;4:e28 pubmed publisher
    ..We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p = 2.9 x 10(-5) in women), with a significant gene-sex effect (p = 1.8 x 10(-4))...
  2. HOE H, Tran T, Matsuoka Y, Howell B, Rebeck G. DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. J Biol Chem. 2006;281:35176-85 pubmed
    ..A ligand for apoEr2, the extracellular matrix protein Reelin, significantly increased the interaction of apoEr2 with Dab1...
  3. Lipska B, Peters T, Hyde T, Halim N, Horowitz C, Mitkus S, et al. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet. 2006;15:1245-58 pubmed
    ..We examined the expression of DISC1 and these selected binding partners as well as reelin, a protein in a related signaling pathway, in the hippocampus and dorsolateral prefrontal cortex of postmortem ..
  4. Sato N, Fukushima N, Chang R, Matsubayashi H, Goggins M. Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers. Gastroenterology. 2006;130:548-65 pubmed
    ..One of the genes identified, RELN (Reelin), a key regulator of neuronal migration, is frequently silenced in pancreatic cancers, as are several of its ..
  5. Deguchi K, Inoue K, Avila W, Lopez Terrada D, Antalffy B, Quattrocchi C, et al. Reelin and disabled-1 expression in developing and mature human cortical neurons. J Neuropathol Exp Neurol. 2003;62:676-84 pubmed
    In developing mammalian (mouse) brain, Reelin (Reln) is secreted by the Cajal-Retzius (CR) neurons in the marginal zone, binds apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (Vldlr), and induces the ..
  6. Benhayon D, Magdaleno S, Curran T. Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res. 2003;112:33-45 pubmed
    b>Reelin, Disabled-1 (Dab1), apolipoprotein E receptor 2 (ApoER2), and very low density lipoprotein receptor (VLDLR) participate in a signaling pathway required for layer formation during mammalian brain development...
  7. Saez Valero J, Costell M, Sjogren M, Andreasen N, Blennow K, Luque J. Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease. J Neurosci Res. 2003;72:132-6 pubmed
    b>Reelin is an essential glycoprotein for correct cytoarchitectonic organization during CNS development...
  8. Senzaki K, Ogawa M, Yagi T. Proteins of the CNR family are multiple receptors for Reelin. Cell. 1999;99:635-47 pubmed
    Layering and positioning of neurons require Reelin- and Src family-associated mammalian Disabled (mDab1)...
  9. Chen M, Chen S, Huang C, Chen C. Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia. Mol Psychiatry. 2002;7:447-8 pubmed
  10. Quattrocchi C, Wannenes F, Persico A, Ciafrè S, D ARCANGELO G, Farace M, et al. Reelin is a serine protease of the extracellular matrix. J Biol Chem. 2002;277:303-9 pubmed
    b>Reelin is an extracellular matrix protein that plays a pivotal role in development of the central nervous system...
  11. Goes F, Willour V, Zandi P, Belmonte P, MacKinnon D, Mondimore F, et al. Sex-specific association of the Reelin gene with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:549-553 pubmed publisher
    The Reelin gene (RELN) encodes a secretory glycoprotein critical for brain development and synaptic plasticity...
  12. Hiesberger T, Trommsdorff M, Howell B, Goffinet A, Mumby M, Cooper J, et al. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 1999;24:481-9 pubmed
    The large extracellular matrix protein Reelin is produced by Cajal-Retzius neurons in specific regions of the developing brain, where it controls neuronal migration and positioning...
  13. Lambert de Rouvroit C, Bernier B, Royaux I, de Bergeyck V, Goffinet A. Evolutionarily conserved, alternative splicing of reelin during brain development. Exp Neurol. 1999;156:229-38 pubmed
    b>Reelin is the protein defective in reeler mutant mice and plays a pivotal role in brain development. However, some uncertainties remain about the relationship between reelin and the reeler phenotype...
  14. Beffert U, Morfini G, Bock H, Reyna H, Brady S, Herz J. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem. 2002;277:49958-64 pubmed
    b>Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 ..
  15. D ARCANGELO G, Miao G, Chen S, Soares H, Morgan J, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995;374:719-23 pubmed
    ..Here we use a previously characterized reeler allele (rl(tg)) to close a gene, reelin, deleted in two reeler alleles...
  16. Goldberger C, Gourion D, Leroy S, Schurhoff F, Bourdel M, Leboyer M, et al. Population-based and family-based association study of 5'UTR polymorphism of the reelin gene and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2005;137B:51-5 pubmed
    b>Reelin is a glycoprotein involved in the migration and positioning of proliferating neurons and synaptic connectivity during neurodevelopment. It may also modulate neuronal plasticity throughout life...
  17. Schrauwen I, Ealy M, Fransen E, Vanderstraeten K, Thys M, Meyer N, et al. Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations. Hum Genet. 2010;127:155-62 pubmed publisher
    ..In a previous study, we identified a region on chr7q22.1 located in the RELN gene that is associated with otosclerosis in Belgian-Dutch and French populations...
  18. Botella Lopez A, Cuchillo Ibanez I, Cotrufo T, Mok S, Li Q, Barquero M, et al. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiol Dis. 2010;37:682-91 pubmed publisher
    b>Reelin is a glycoprotein that modulates synaptic function and plasticity in the mature brain, thereby favouring memory formation. We recently reported altered cerebral Reelin expression in Alzheimer's disease (AD)...
  19. Wang Q, Lu J, Yang C, Wang X, Cheng L, Hu G, et al. CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma. Cancer Lett. 2002;179:71-7 pubmed
    ..The upregulation of CASK gene and its target gene Reelin in human esophageal carcinoma tissues versus corresponding normal tissues was revealed by reverse transcription ..
  20. Akahane A, Kunugi H, Tanaka H, Nanko S. Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia. Schizophr Res. 2002;58:37-41 pubmed
    Several lines of evidence suggest a possible role for reelin in the pathogenesis of neurodevelopmental diseases, particularly schizophrenia...
  21. Impagnatiello F, Guidotti A, Pesold C, Dwivedi Y, Caruncho H, Pisu M, et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci U S A. 1998;95:15718-23 pubmed
    ..nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content...
  22. Rice D, Curran T. Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci. 2001;24:1005-39 pubmed
    ..Indeed, the identification of reelin has challenged many of our previous notions and has led to a new vision of the events involved in the migration of ..
  23. Tost H, Lipska B, Vakkalanka R, Lemaitre H, Callicott J, Mattay V, et al. No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression. Biol Psychiatry. 2010;68:105-7 pubmed publisher
    A recent genome-wide association study linked a common variant in RELN (rs7341475G) with risk for schizophrenia in women...
  24. Schrauwen I, Ealy M, Huentelman M, Thys M, Homer N, Vanderstraeten K, et al. A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. Am J Hum Genet. 2009;84:328-38 pubmed publisher
    ..23 x 10(-10), is on chromosome 7q22.1 and spans intron 1 to intron 4 of reelin (RELN), a gene known for its role in neuronal migration...
  25. Dohi O, Takada H, Wakabayashi N, Yasui K, Sakakura C, Mitsufuji S, et al. Epigenetic silencing of RELN in gastric cancer. Int J Oncol. 2010;36:85-92 pubmed
    RELN (Reelin) is an extracellular glycoprotein that plays a critical role in neuronal migration. Here we show that the RELN gene is frequently silenced in gastric cancers (GCs) by aberrant promoter hypermethylation...
  26. Khalfallah A, Schrauwen I, Mnaja M, Fransen E, Lahmar I, Ealy M, et al. Genetic variants in RELN are associated with otosclerosis in a non-European population from Tunisia. Ann Hum Genet. 2010;74:399-405 pubmed publisher
    ..1, located in the RELN gene, and one on chr11q13.1...
  27. Hong S, Shugart Y, Huang D, Shahwan S, Grant P, Hourihane J, et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat Genet. 2000;26:93-6 pubmed
    ..and brainstem maps to chromosome 7q22, and is associated with two independent mutations in the human gene encoding reelin (RELN). The mutations disrupt splicing of RELN cDNA, resulting in low or undetectable amounts of reelin protein...
  28. Priyadarshi S, Panda K, Panda A, Ramchander P. Lack of association between SNP rs3914132 of the RELN gene and otosclerosis in India. Genet Mol Res. 2010;9:1914-20 pubmed publisher
    ..Recently, a reelin gene, SNP rs3914132, located in intron 2, was shown to be associated with otosclerosis in a European population...
  29. Fatemi S, Kroll J, Stary J. Altered levels of Reelin and its isoforms in schizophrenia and mood disorders. Neuroreport. 2001;12:3209-15 pubmed
    b>Reelin is a secreted extracellular matrix protein approximately 410 kDa mol. wt that is reduced in brains of patients with schizophrenia, autism, bipolar disorder and major depression...
  30. Grayson D, Jia X, Chen Y, Sharma R, Mitchell C, Guidotti A, et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A. 2005;102:9341-6 pubmed
    b>Reelin mRNA and protein levels are reduced by approximately 50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis...
  31. Csomor P, Sziklai I, Karosi T. Controversies in RELN/reelin expression in otosclerosis. Eur Arch Otorhinolaryngol. 2012;269:431-40 pubmed publisher
    ..4), hearing ossicles (n = 2) and human brain tissue specimens (n = 4) were processed to RELN-specific RT-PCR and reelin-specific immunofluorescent assay (IFA)...
  32. Ignatova N, Sindic C, Goffinet A. Characterization of the various forms of the Reelin protein in the cerebrospinal fluid of normal subjects and in neurological diseases. Neurobiol Dis. 2004;15:326-30 pubmed
    b>Reelin is a large extracellular glycoprotein that is defective in reeler mutant mice and plays a well-established role during brain development in human as well as rodents...
  33. Herring A, Donath A, Steiner K, Widera M, Hamzehian S, Kanakis D, et al. Reelin depletion is an early phenomenon of Alzheimer's pathology. J Alzheimers Dis. 2012;30:963-79 pubmed publisher
    Alterations in the expression of Reelin (RELN) have been implicated in the pathology of Alzheimer's disease (AD). However, whether these changes are cause or consequence of AD remains to be resolved...
  34. Krstic D, Rodríguez M, Knuesel I. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE. 2012;7:e47793 pubmed publisher
    The extracellular signaling protein Reelin, indispensable for proper neuronal migration and cortical layering during development, is also expressed in the adult brain where it modulates synaptic functions...
  35. Ben David E, Shifman S. Further investigation of the association between rs7341475 and rs17746501 and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1244-7 pubmed publisher
  36. Seripa D, Matera M, Franceschi M, Daniele A, Bizzarro A, Rinaldi M, et al. The RELN locus in Alzheimer's disease. J Alzheimers Dis. 2008;14:335-44 pubmed
    b>Reelin, a serine protease encoded by the RELN gene, is part of the apolipoprotein E (apoE) biochemical pathway that is involved in the pathogenesis of Alzheimer's disease (AD)...
  37. Chin J, Massaro C, Palop J, Thwin M, Yu G, Bien Ly N, et al. Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. J Neurosci. 2007;27:2727-33 pubmed
    b>Reelin regulates nervous system development and modulates synaptic plasticity in the adult brain...
  38. Huang C, Chen C. Absence of association of a polymorphic GGC repeat at the 5' untranslated region of the reelin gene with schizophrenia. Psychiatry Res. 2006;142:89-92 pubmed
    b>Reelin is an extracellular matrix glycoprotein that plays an important role in guiding neuronal migration, lamination and connection during embryonic brain development...
  39. Eastwood S, Harrison P. Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Mol Psychiatry. 2003;8:769, 821-31 pubmed
    ..Secondly, decreased expression of reelin, a key developmental signalling molecule...
  40. Klein K, Pendziwiat M, Cohen R, Appenzeller S, de Kovel C, Rosenow F, et al. Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. J Neurol. 2016;263:11-6 pubmed publisher
    ..We performed linkage analysis and exome sequencing. LGI1, KANK1 and RELN were Sanger sequenced. Seizure semiology of 11 individuals was consistent with ADEAF...
  41. Miyoshi G, Young A, PETROS T, Karayannis T, McKenzie Chang M, Lavado A, et al. Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons. J Neurosci. 2015;35:12869-89 pubmed publisher
    Neurogliaform (RELN+) and bipolar (VIP+) GABAergic interneurons of the mammalian cerebral cortex provide critical inhibition locally within the superficial layers...
  42. Roberts R, Xu L, Roche J, Kirkpatrick B. Ultrastructural localization of reelin in the cortex in post-mortem human brain. J Comp Neurol. 2005;482:294-308 pubmed
    b>Reelin is a glycoprotein that plays a critical role in brain development, including proper cortical lamination. In adult animals, reelin continues to be expressed in different neuronal populations in many brain regions...
  43. Nabil Fikri R, Norlelawati A, Nour El Huda A, Hanisah M, Kartini A, Norsidah K, et al. Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia. J Psychiatr Res. 2017;88:28-37 pubmed publisher
    The epigenetic changes of RELN that are involved in the development of dopaminergic neurons may fit the developmental theory of schizophrenia...
  44. Wang Z, Hong Y, Zou L, Zhong R, Zhu B, Shen N, et al. Reelin gene variants and risk of autism spectrum disorders: an integrated meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2014;165B:192-200 pubmed publisher
    Autism spectrum disorder (ASD) is a severe neurological disorder with a high degree of heritability. Reelin gene (RELN), which plays a crucial role in the migration and positioning of neurons during brain development, has been strongly ..
  45. Zhang H, Liu X, Zhang C, Mundo E, Macciardi F, Grayson D, et al. Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry. 2002;7:1012-7 pubmed
    A polymorphic trinucleotide repeat (CGG/GCC) within the human Reelin gene (RELN) was examined as a candidate gene for autism spectrum disorders (ASDs)...
  46. Khialeeva E, Carpenter E. Nonneuronal roles for the reelin signaling pathway. Dev Dyn. 2017;246:217-226 pubmed publisher
    The reelin signaling pathway has been established as an important regulator of cell migration during development of the central nervous system, and disruptions in reelin signaling alter the positioning of many types of neurons...
  47. Tian P. RELN gene polymorphisms and susceptibility to autism in Chinese Han population. Neurol India. 2012;60:581-4 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the Reelin gene (RELN) are likely candidates to confer risk for autism. The objective of the present study is to investigate the association of RELN gene SNPs with autism...
  48. Evangelisti C, Florian M, Massimi I, Dominici C, Giannini G, Galardi S, et al. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J. 2009;23:4276-87 pubmed publisher
    ..cells, where it down-modulates the expression of two proteins involved in the migratory potential of neural cells: Reelin and DCX...
  49. Atucha E, Vukojevic V, Fornari R, Ronzoni G, Demougin P, Peter F, et al. Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory. Proc Natl Acad Sci U S A. 2017;114:9176-9181 pubmed publisher
    ..was paralleled by time-regulated DNA methylation and transcriptional changes of memory-related genes, namely Reln and Pkm?, in the hippocampus and neocortex...
  50. Antoniades D, Katopodi T, Pappa S, Lampropoulos A, Konsta V, Frydas E, et al. The role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease in a Greek population. J Biol Regul Homeost Agents. 2011;25:351-8 pubmed
    b>Reelin is an extracellular signaling glycoprotein, which plays a significant role in cytoarchitectonic pattern formation of different brain areas during development. Reelin gene is located on chromosome 7q22...
  51. Kelemenova S, Schmidtova E, Ficek A, Celec P, Kubranska A, Ostatnikova D. Polymorphisms of candidate genes in Slovak autistic patients. Psychiatr Genet. 2010;20:137-9 pubmed publisher
    ..have focused on oxytocin (OT), oxytocin receptor (OXTR), GABA receptor gamma 3 (GABRG3), neuroligin (NLGN4X), and reelin (RELN). After signed consent, 90 autistic boys and 85 healthy controls were enrolled in the study...
  52. Yang X, Kang C, Liu H, Yang J. Association study of the reelin (RELN) gene with Chinese Va schizophrenia. Psychiatr Genet. 2013;23:138 pubmed publisher
  53. Persico A, D Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, et al. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol Psychiatry. 2001;6:150-9 pubmed
    Autistic disorder (MIM 209850) is currently viewed as a neurodevelopmental disease. Reelin plays a pivotal role in the development of laminar structures including the cerebral cortex, hippocampus, cerebellum and of several brainstem ..
  54. Li W, Guo X, Xiao S. Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: A meta-analysis. Neurosci Lett. 2015;609:42-7 pubmed publisher
    Studies have suggested that reelin (RELN) polymorphism was associated with the susceptibility of schizophrenia (SZ), but the results remained controversial...
  55. Bučić M, Pregelj P, Zupanc T, Videtič Paska A. Completed suicide, depression, and RELN polymorphisms. Psychiatr Genet. 2016;26:218-22 pubmed publisher
    ..In the present study, we looked for a potential association between suicide and the reelin gene as reelin has been associated previously with several psychiatric disorders, including depression...
  56. Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed
    Apolipoprotein E receptor 2 (apoER2) is an important participant in the Reelin signaling pathway that directs cell positioning during embryogenesis...
  57. Yuan Y, Chen H, Ma G, Cao X, Liu Z. Reelin is involved in transforming growth factor-?1-induced cell migration in esophageal carcinoma cells. PLoS ONE. 2012;7:e31802 pubmed publisher
    b>Reelin (RELN), which is a glycoprotein secreted by Cajal-Retzius cells of the developing cerebral cortex, plays an important role in neuronal migration, but its role in cell migration and cancer metastasis is largely unclear...
  58. Dazzo E, Fanciulli M, Serioli E, Minervini G, Pulitano P, Binelli S, et al. Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy. Am J Hum Genet. 2015;96:992-1000 pubmed publisher
    ..Here, we report the identification of causal mutations in reelin (RELN) in seven ADLTE-affected families without LGI1 mutations...
  59. Tamura Y, Kunugi H, Ohashi J, Hohjoh H. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry. 2007;12:519, 593-600 pubmed
    ..that the levels of DNA methylation at the BssHII methylation-sensitive restriction enzyme sites in the human REELIN (RELN) gene in the forebrain vary among individuals...
  60. Castellano E, Molina Arcas M, Krygowska A, East P, Warne P, Nicol A, et al. RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. Nat Commun. 2016;7:11245 pubmed publisher
    ..in cells lacking RAS interaction with p110? reveals increased levels of the extracellular matrix glycoprotein Reelin and activation of its downstream pathway resulting in upregulation of E-cadherin expression...
  61. Ohkubo N, Vitek M, Morishima A, Suzuki Y, Miki T, Maeda N, et al. Reelin signals survival through Src-family kinases that inactivate BAD activity. J Neurochem. 2007;103:820-30 pubmed
    b>Reelin plays an important role in the migration of embryonic neurons, but its continuing presence suggests additional functions in the brain...
  62. Panteri R, Paiardini A, Keller F. A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Brain Res. 2006;1116:222-30 pubmed
    b>Reelin is a large molecule of the extracellular matrix (ECM) which regulates neuronal positioning during the early stages of cortical development in vertebrate species...
  63. Protsenko E, Vasilyeva M, Peretyatko L. [Specific features of reelin expression in the brain of fetuses and newborns with internal hydrocephalus]. Arkh Patol. 2016;78:3-7 pubmed publisher
    to study reelin expression in the neocortex of fetuses and newborns with internal hydrocephalus (HC) and to reveal its features in relation to the etiology of HC...
  64. Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher
    ..Moreover, the targeted resequencing screening detected heterozygous variants in RELN in two cases, of uncertain pathogenicity, and WES analysis suggested that concurrent mutations of both DYNC1H1 and ..