regulator of Fas induced apoptosis

Summary

Gene Symbol: regulator of Fas induced apoptosis
Description: Fc fragment of IgM receptor
Alias: FAIM3, TOSO, fas apoptotic inhibitory molecule 3, Fc mu receptor, IgM Fc fragment receptor, IgM Fc receptor, immunoglobulin mu Fc receptor, regulator of Fas-induced apoptosis Toso
Species: human

Top Publications

  1. Yi S, Yu Z, Zhou K, Wang Y, An G, Li Z, et al. TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2011;52:72-8 pubmed publisher
    Recently, a gene named TOSO was identified as being overexpressed and associated with the anti-apoptotic characteristic of chronic lymphocytic leukemia (CLL)...
  2. Hitoshi Y, Lorens J, Kitada S, Fisher J, LaBarge M, Ring H, et al. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity. 1998;8:461-71 pubmed
    ..Using retroviral cDNA library-based functional cloning we identified a gene, toso, that blocks Fas-mediated apoptosis...
  3. Proto Siqueira R, Panepucci R, Careta F, Lee A, Clear A, Morris K, et al. SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Blood. 2008;112:394-7 pubmed publisher
    ..A gene ontology analysis revealed that TOSO, which plays a functional role upstream of Fas extrinsic apoptosis pathway, was over-expressed in CLL cells...
  4. Pallasch C, Schulz A, Kutsch N, Schwamb J, Hagist S, Kashkar H, et al. Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease. Blood. 2008;112:4213-9 pubmed publisher
    ..b>TOSO was identified as overexpressed candidate gene in CLL, applying unit-transformation assays of publicly available ..
  5. Świontek M, Fraczyk J, Wasko J, Chaberska A, Pietrzak L, Kaminski Z, et al. Search for New Aggregable Fragments of Human Insulin. Molecules. 2019;24: pubmed publisher
    ..solid-phase synthesis using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TosO-) as a coupling reagent...
  6. Rackow A, Ehmen C, von Possel R, Medialdea Carrera R, Brown D, Bispo de Filippis A, et al. Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies. Clin Chem. 2019;65:451-461 pubmed publisher
    The cellular surface molecule HsTOSO/FAIM3/HsFcμR has been identified as an IgM-specific Fc receptor expressed on lymphocytes...
  7. Kolesińska B, Chaberska A, Fraczyk J, Wasko J, Rosiak P, Kaminski Z, et al. Study on the Materials Formed by Self-Assembling Hydrophobic, Aromatic Peptides Dedicated to Be Use for Regenerative Medicine. Chem Biodivers. 2018;: pubmed publisher
    ..All tested hydrophobic peptides were prepared on solid phase by using DMT/NMM/TosO- as a coupling reagent. The aggregation was studied by set of independent tests...
  8. Dkhil M, Metwaly M, Al Quraishy S, Sherif N, Delic D, Al Omar S, et al. Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata. Parasitol Res. 2015;114:1581-93 pubmed publisher
    ..Berberine downregulates the genes Xaf1, Itgb3bp, and Faim3 involved in apoptotic processes and upregulates genes involved in innate immune responses, as e.g...
  9. Maslove D, Shapira T, Tyryshkin K, Veldhoen R, Marshall J, Muscedere J. Validation of diagnostic gene sets to identify critically ill patients with sepsis. J Crit Care. 2019;49:92-98 pubmed publisher
    ..of 3 expression-based sepsis scores including 1) the Sepsis MetaScore (SMS); 2) the SeptiCyte™ Lab; and 3) the FAIM3:PLAC8 ratio...

More Information

Publications32

  1. Lang P, Meryk A, Pandyra A, Brenner D, Brüstle A, Xu H, et al. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015;22:164-73 pubmed publisher
    ..We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro...
  2. Kubagawa H, Kubagawa Y, Jones D, Nasti T, Walter M, Honjo K. The old but new IgM Fc receptor (FcμR). Curr Top Microbiol Immunol. 2014;382:3-28 pubmed publisher
    ..Since the FcμR we cloned was identical to Toso or Fas inhibitory molecule 3 (FAIM3), there have been spirited debates regarding the real function of FcμR/Toso/FAIM3 and we will also comment on ..
  3. Gaublomme J, Yosef N, Lee Y, Gertner R, Yang L, Wu C, et al. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell. 2015;163:1400-12 pubmed publisher
    ..Using knockout mice, we validate four new genes: Gpr65, Plzp, Toso, and Cd5l (in a companion paper)...
  4. Lapke N, Tartz S, Lee K, Jacobs T. The application of anti-Toso antibody enhances CD8(+) T cell responses in experimental malaria vaccination and disease. Vaccine. 2015;33:6763-70 pubmed publisher
    b>Toso is a molecule highly expressed on B cells. It influences their survival and was identified as an IgM binding molecule. B cells and natural antibodies play a role in vaccination-induced CD8(+) T cell responses...
  5. Dkhil M, Khalil M, Al Quraishy S. Profiling of jejunum inflammatory gene expression during murine eimeriosis. Microb Pathog. 2017;104:196-201 pubmed publisher
    ..papillata. The expression profiles of the Fas apoptotic inhibitory molecule 3(FAIM3), chemokine (C-X-C motif) receptor 5 (Cxcr5), succinate receptor 1 (SUCNR1), hydroxy-delta-5-..
  6. Faitschuk E, Hombach A, Frenzel L, Wendtner C, Abken H. Chimeric antigen receptor T cells targeting Fc ? receptor selectively eliminate CLL cells while sparing healthy B cells. Blood. 2016;128:1711-22 pubmed publisher
    ..We identified the immunoglobulin M Fc receptor (Fc?R), also known as the Fas apoptotic inhibitory molecule-3 or TOSO, as a target for a more selective treatment of CLL by CAR T cells...
  7. Świontek M, Rożniakowski K, Fraczyk J, Lipiński W, Galecki K, Wysocki S, et al. The quest for the shortest fragments of A (13-19) and B (12-17) responsible for the aggregation of human insulin. Nanomedicine (Lond). 2016;11:2083-101 pubmed publisher
    ..Fragments A13-A19 and B12-B17 of insulin and all shortened analogues were obtained by using DMT/NMM/TosO(-) as a coupling reagent. The aggregation was studied by three independent tests...
  8. Nevalainen T, Kananen L, Marttila S, Jylhä M, Hervonen A, Hurme M, et al. Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study. Age (Dordr). 2015;37:9814 pubmed publisher
    ..Among these genes were IL1RN, CREB5, and FAIM3, which mapped to a network of inflammatory response genes...
  9. Murakami Y, Narayanan S, Su S, Childs R, Krzewski K, Borrego F, et al. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. J Immunol. 2012;189:587-97 pubmed publisher
    We find that the cell surface receptor Toso is dramatically downregulated by in vitro stimulation of human T and NK cells with IL-2 in a STAT5-dependent manner...
  10. Yu Z, Zhou K, Li Z, Yi S, Hao M, Li C, et al. [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients]. Zhonghua Yi Xue Za Zhi. 2011;91:1371-4 pubmed
    To investigate the expression and its prognostic significance of TOSO in CD19(+) B cells from Chinese chronic lymphocytic leukemia (CLL) patients...
  11. Kubagawa H, Carroll M, Jacob C, Lang K, Lee K, Mak T, et al. Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. J Immunol. 2015;194:4055-7 pubmed publisher
    ..the cell surface glycoprotein presently designated by different names: Toso, Fas apoptosis inhibitory molecule 3 (FAIM3), and IgM FcR (FcμR)...
  12. Li F, Kubagawa Y, McCollum M, Wilson L, Motohashi T, Bertoli L, et al. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. Blood. 2011;118:4902-9 pubmed publisher
    ..These findings indicate enhanced levels of both membrane-bound and soluble forms of Fc?R in CLL patients. ..
  13. Hancer V, Diz Kucukkaya R, Aktan M. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. Med Oncol. 2012;29:1068-72 pubmed publisher
    ..Intracellular upregulation of Fc mu receptor (FCMR, FAIM3/TOSO) gene in the leukemic lymphocytes of the patients with CLL may be an important parameter in ..
  14. Planells Ferrer L, Urresti J, Coccia E, Galenkamp K, Calleja Yagüe I, Lopez Soriano J, et al. Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system. J Neurochem. 2016;139:11-21 pubmed publisher
    ..Although FAIM1, FAIM2, and FAIM3 inhibit Fas-induced cell death, they are not structurally related, nor do they share expression patterns...
  15. Czajkowsky D, Salanti A, Ditlev S, Shao Z, Ghumra A, Rowe J, et al. IgM, Fc mu Rs, and malarial immune evasion. J Immunol. 2010;184:4597-603 pubmed publisher
  16. Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, et al. Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int Immunol. 2010;22:149-56 pubmed publisher
    ..As a result, we identified TOSO/Fas apoptotic inhibitory molecule 3 (FAIM3) as a possible Fc receptor for IgM...
  17. Sigruener A, Buechler C, Bared S, Grandl M, Aslanidis C, Ugocsai P, et al. E-LDL upregulates TOSO expression and enhances the survival of human macrophages. Biochem Biophys Res Commun. 2007;359:723-8 pubmed
    ..treated with enzymatically modified LDL (E-LDL) were subjected to GeneChip analysis and the antiapoptotic gene TOSO was found induced...
  18. Pallasch C, Wendtner C. Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia. Leuk Lymphoma. 2009;50:498-501 pubmed publisher
    ..In this context, TOSO, also known as Fas-inhibitory molecule 3, was identified as a candidate gene over-expressed in CLL...
  19. Ma Y, Liu W, Zhang L, Jia G. Effects of Histone Deacetylase Inhibitor Panobinostat (LBH589) on Bone Marrow Mononuclear Cells of Relapsed or Refractory Multiple Myeloma Patients and Its Mechanisms. Med Sci Monit. 2017;23:5150-5157 pubmed
    ..05). The mRNA level of Caspase3 and APAF1 were up-regulated gradually, while TOSO gene expression in RRMM-BMMNC was down-regulated gradually in a dose- and time-dependent manner...
  20. Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang D, et al. Identity of the elusive IgM Fc receptor (FcmuR) in humans. J Exp Med. 2009;206:2779-93 pubmed publisher
    ..Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated ..
  21. Vire B, David A, Wiestner A. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. J Immunol. 2011;187:4040-50 pubmed publisher
    TOSO/FAIM3 recently has been identified as the long-sought-after FcR for IgM (FcμR)...
  22. Nguyen X, Lang P, Lang K, Adam D, Fattakhova G, Föger N, et al. Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 2011;118:598-608 pubmed publisher
    ..Here, we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor ..
  23. Rainsford K, James C, Hunt R, Stetsko P, Rischke J, Karim A, et al. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. Clin Pharmacol Ther. 1992;51:415-21 pubmed
    ..Thus misoprostol does not interfere with the absorption of indomethacin despite the known inhibitory effects of this protaglandin analog on acid secretion. ..