REG1A

Summary

Gene Symbol: REG1A
Description: regenerating family member 1 alpha
Alias: ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, lithostathine-1-alpha, REG-1-alpha, islet cells regeneration factor, islet of langerhans regenerating protein, pancreatic stone protein, secretory, pancreatic thread protein, protein-X, regenerating islet-derived protein 1-alpha, regenerating protein I alpha
Species: human
Products:     REG1A

Top Publications

  1. Banchuin N, Boonyasrisawat W, Pulsawat P, Vannasaeng S, Deerochanawong C, Sriussadaporn S, et al. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. Diabetes Res Clin Pract. 2002;55:105-11 pubmed
    ..In conclusion, using PCR-SSCP and nucleotide sequence analyses, we did not find any association between abnormalities of either reg1 alpha or reg1 beta gene with any type of diabetes studied. ..
  2. Fukui H, Fujii S, Takeda J, Kayahara T, Sekikawa A, Nanakin A, et al. Expression of reg I alpha protein in human gastric cancers. Digestion. 2004;69:177-84 pubmed
    Although regenerating gene(Reg) I alpha protein has a trophic effect on gastric epithelial cells, it is unclear whether Reg I alpha protein and its receptor are involved in gastric carcinogenesis...
  3. Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, et al. REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer. Gastroenterology. 2005;128:642-53 pubmed
    Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear...
  4. Kiji T, Dohi Y, Takasawa S, Okamoto H, Nonomura A, Taniguchi S. Activation of regenerating gene Reg in rat and human hearts in response to acute stress. Am J Physiol Heart Circ Physiol. 2005;289:H277-84 pubmed
    Recently, the regenerating gene (Reg) has been documented to play an important role in various regenerating tissues, but it is unknown whether the Reg gene could be activated in the heart...
  5. Usami S, Motoyama S, Koyota S, Wang J, Hayashi Shibuya K, Maruyama K, et al. Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells. Biochem Biophys Res Commun. 2010;392:4-8 pubmed publisher
    Regenerating gene (REG) I plays important roles in cancer cell biology. The purpose of this study was to determine whether REG I affects cytokine production in cancer cells...
  6. Yoshimoto K, Fujimoto T, Itaya Hironaka A, Miyaoka T, Sakuramoto Tsuchida S, Yamauchi A, et al. Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome. Clin Exp Immunol. 2013;174:1-9 pubmed publisher
    The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regenerating pancreatic islets and constitute a growth factor family...
  7. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 1990;265:7432-9 pubmed
    ..1989) Biochim. Biophys. Acta 994, 281-284) and the partially determined 45-amino acid sequence of pancreatic thread protein (Gross, J., Carlson, R. I., Brauer, A. W., Margolies, M. N., Warshaw, A. L., and Wands, J. R. (1985) J...
  8. Astrosini C, Roeefzaad C, Dai Y, Dieckgraefe B, Jöns T, Kemmner W. REG1A expression is a prognostic marker in colorectal cancer and associated with peritoneal carcinomatosis. Int J Cancer. 2008;123:409-413 pubmed publisher
    By expression profiling of early staged colon carcinomas, we found regenerating islet-derived 1 alpha (REG1A) to be upregulated in patients with an unfavorable clinical outcome...
  9. Yamagishi H, Fukui H, Sekikawa A, Kono T, Fujii S, Ichikawa K, et al. Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers. Mod Pathol. 2009;22:906-13 pubmed publisher
    Regenerating gene family members 1 (REG Ialpha) and 4 (REG IV) are overexpressed in a subset of gastric cancers. However, comparative characterization of the expression of these family proteins has remained unclear...

More Information

Publications111 found, 100 shown here

  1. Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, et al. Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 2010;127:1795-803 pubmed publisher
    ..Regenerating gene (REG) Ialpha is a growth factor affecting pancreatic islet beta cells, and it has been shown to be involved in the ..
  2. Sasaki Y, Minamiya Y, Takahashi N, Nakagawa T, Katayose Y, Ito A, et al. REG1A expression is an independent factor predictive of poor prognosis in patients with breast cancer. Ann Surg Oncol. 2008;15:3244-51 pubmed publisher
    Regenerating gene I alpha (REG1A) is a growth factor known to affect pancreatic islet beta cells...
  3. Hayashi K, Motoyama S, Koyota S, Koizumi Y, Wang J, Takasawa S, et al. REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. Cancer Sci. 2008;99:2491-5 pubmed publisher
    ..To test whether regenerating gene (REG) I expression enhances chemo- and radiosensitivity in esophageal squamous cell carcinoma cells, we used MTT (3-[4,5-..
  4. Okamoto H. The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. J Hepatobiliary Pancreat Surg. 1999;6:254-62 pubmed
    ..In screening the regenerating islet-derived cDNA library, we found a novel gene and named it Reg (i.e., regenerating gene)...
  5. Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, et al. REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Carcinogenesis. 2008;29:76-83 pubmed
    ..Regenerating gene (REG) Ialpha protein, an interleukin (IL)-6-inducible gene, is suggested to be involved in the gastritis-gastric cancer ..
  6. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, et al. A novel gene activated in regenerating islets. J Biol Chem. 1988;263:2111-4 pubmed
    ..We also found that a human pancreas-derived cDNA library contained a homologue to the gene. ..
  7. Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, et al. Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1994;1217:199-202 pubmed
    ..a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human reg protein, regI alpha...
  8. Sanchez D, Figarella C, Marchand Pinatel S, Bruneau N, Guy Crotte O. Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun. 2001;284:729-37 pubmed
    In human pancreas two genes, reg I alpha and reg I beta, have been characterized but only the reg I alpha protein has been isolated from human pancreatic secretion...
  9. Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, et al. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer. 2003;98:1394-400 pubmed
    The Reg gene is known to be involved in the growth of not only pancreatic B-cells, but also epithelial cells of the gastrointestinal tract and carcinoma of its lineage...
  10. Hayashi K, Motoyama S, Sugiyama T, Izumi J, Anbai A, Nanjo H, et al. REG Ialpha is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients. Ann Surg Oncol. 2008;15:1224-31 pubmed publisher
    ..We investigated whether regenerating gene (REG) Ialpha is such a marker...
  11. Higham A, Bishop L, Dimaline R, Blackmore C, Dobbins A, Varro A, et al. Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology. 1999;116:1310-8 pubmed
    The RegIalpha gene (Reg) encodes a secretory protein proposed to regulate islet beta-cell and gastric mucous cell growth. Reg is expressed in rat gastric enterochromaffin-like (ECL) cells...
  12. Dhar D, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, et al. Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer. 2004;100:1130-6 pubmed
    Regenerating gene I (REG) was identified as a growth factor for pancreatic islet beta cells. Enhanced REG expression was observed during the healing of gastric mucosa...
  13. Sekikawa A, Fukui H, Suzuki K, Karibe T, Fujii S, Ichikawa K, et al. Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. Lab Invest. 2010;90:496-505 pubmed publisher
    The Regenerating gene (REG) Ialpha protein, a trophic and/or anti-apoptotic factor, is important in the pathophysiology of gastrointestinal inflammation...
  14. Ota H, Itaya Hironaka A, Yamauchi A, Sakuramoto Tsuchida S, Miyaoka T, Fujimura T, et al. Pancreatic ? cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Life Sci. 2013;93:664-72 pubmed publisher
    ..The expression of regenerating gene (Reg) family, interleukin (IL)-6, and hepatocyte growth factor (HGF) was determined by real-time RT-PCR...
  15. Ndisang J. The heme oxygenase system selectively modulates proteins implicated in metabolism, oxidative stress and inflammation in spontaneously hypertensive rats. Curr Pharm Des. 2014;20:1318-27 pubmed
    ..In addition, the effects of hemin on endothelin-1 (ET-1), protein-tyrosine-phosphatase-1B (PTP-1B), atrial-natriuretic-peptide (ANP) and its surrogate-marker urinary cGMP, and inflammatory cytokines including ..
  16. Heneberg P. Finding the smoking gun: protein tyrosine phosphatases as tools and targets of unicellular microorganisms and viruses. Curr Med Chem. 2012;19:1530-66 pubmed
    ..Interfering with tyrosine phosphorylation represents a powerful pharmacologic approach, and even though the PTP inhibitors are difficult to develop, lifting the fog of phosphatase inhibition is of the great market potential and ..
  17. McLachlan D, Bergeron C, Alexandrov P, Walsh W, Pogue A, Percy M, et al. Aluminum in Neurological and Neurodegenerative Disease. Mol Neurobiol. 2019;56:1531-1538 pubmed publisher
    ..syndrome (GSS), progressive multifocal leukoencephalopathy (PML; N = 11), progressive supranuclear palsy (PSP; N = 24), schizophrenia (SCZ; N = 21), a young control group (YCG; N = 22; mean age, 10.2 ± 6...
  18. Schmechel D, Edwards C. Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology. 2012;33:1454-1472 pubmed publisher
    ..Toxic environmental exposures are common (23%) and associated with diagnoses of PSP, PPA, FTD, FTD-PD, PD and ADVD. A1AT carriers were increased in cases of toxic exposure and PSP, PPA and FTD-PD...
  19. Mironova G, Avdonin P, Goncharov N, Jenkins R, Avdonin P. Inhibition of protein tyrosine phosphatases unmasks vasoconstriction and potentiates calcium signaling in rat aorta smooth muscle cells in response to an agonist of 5-HT2B receptors BW723C86. Biochem Biophys Res Commun. 2017;483:700-705 pubmed publisher
    ..in smooth muscle cells (SMC) due to oxidative stress induced inhibition of protein tyrosine phosphatases (PTP)...
  20. Kim D, Yu J, Mui R, Niibori R, Taufique H, Aslam R, et al. The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation. Dis Model Mech. 2017;10:581-595 pubmed publisher
    ..the anx mutation, and its mRNA localization appeared abnormal in anx/anx brains by postnatal day 19 (P19)...
  21. Chang B, Cui B, Ullah H, Li S, Hao K, Tu X, et al. Role of PTP/PTK trans activated insulin-like signalling pathway in regulation of grasshopper (Oedaleus asiaticus) development. Environ Sci Pollut Res Int. 2019;26:8312-8324 pubmed publisher
    ..This showed that in the ILP of O. asiaticus, PTK5 was detrimental to growth, body mass and overall performance, which ultimately benefited insect detoxification with high-energy cost. ..
  22. Chen J, Li H, Yang J, Zhan R, Chen A, Yan Y. Prevalence and Characterization of Integrons in Multidrug Resistant Acinetobacter baumannii in Eastern China: A Multiple-Hospital Study. Int J Environ Res Public Health. 2015;12:10093-105 pubmed publisher
    ..05). PFGE assay revealed 27 PFGE genotypes and 4 predominant genotypes, P1, P4, P7 and P19. The PFGE genotype P1 contained 13 extensive-drug resistant and 89 non-extensive-drug resistant A...
  23. Senathilake K, Karunanayake E, Samarakoon S, Tennekoon K, de Silva E. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Exp Parasitol. 2016;167:50-60 pubmed publisher
    ..in caspase 3/CED 3 and a decrease in total protein content, cyclooxygenase (COX) and protein tyrosine phosphatase (PTP) activities were observed in adult parasites treated with hexane or chloroform extract...
  24. Matsumoto A, Suzuki H, Fukatsu R, Shimizu H, Suzuki Y, Hisanaga K. An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome. Neuropathology. 2016;36:77-87 pubmed publisher
    ..Common background pathologies for CBS include corticobasal degeneration, Alzheimer's disease, PSP, FTLD with phosphorylated TDP-43 inclusions (FTLD-TDP), Pick's disease, Lewy body disease and CJD...
  25. Deodhar A, Gottlieb A, Boehncke W, Dong B, Wang Y, Zhuang Y, et al. Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2018;391:2213-2224 pubmed publisher
    Guselkumab, a human monoclonal antibody that binds to the p19 subunit of interleukin 23, has been approved for the treatment of moderate-to-severe psoriasis...
  26. Rojas A, Dvir E, Farkas R, Sarma K, Borthakur S, Jabbar A, et al. Phylogenetic analysis of Spirocerca lupi and Spirocerca vulpis reveal high genetic diversity and intra-individual variation. Parasit Vectors. 2018;11:639 pubmed publisher
    ..42-6.74%). This genetic diversity led to the identification of two S. lupi genotypes circulating among dogs (PTP support > 0.829), including genotype 1 found in S...
  27. Leyk J, Goldbaum O, Noack M, Richter Landsberg C. Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol Neurosci. 2015;55:1031-46 pubmed publisher
    ..of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)...
  28. Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, et al. DPF2 regulates OCT4 protein level and nuclear distribution. Biochim Biophys Acta. 2015;1853:3279-93 pubmed publisher
    ..Endogenous interaction between DPF2 and OCT4 in P19 cells was revealed by an immunoprecipitation assay...
  29. Antony A, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, et al. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016;7:10955 pubmed publisher
    ..Ca(2+) overload-induced mitochondrial permeability transition pore (PTP) opening is accelerated in MICU1-deficient hepatocytes. PTP inhibition prevents necrosis and rescues regeneration...
  30. Thein K, Myint Z, Tun A, Oo T. Cancer Associated Thrombosis: Focus on Prevention and Treatment of Venous Thromboembolism. Cardiovasc Hematol Agents Med Chem. 2016;: pubmed
    ..While the role of pharmacologic thromboprophylaxis (PTP) is established in the hospitalized cancer patients, ambulatory PTP is not, except in patients with multiple ..
  31. Huppertz H, Möller L, Südmeyer M, Hilker R, Hattingen E, Egger K, et al. Differentiation of neurodegenerative parkinsonian syndromes by volumetric magnetic resonance imaging analysis and support vector machine classification. Mov Disord. 2016;31:1506-1517 pubmed publisher
    ..volumetry was performed on MRI data of healthy controls (n = 73) and patients with PD (204), PSP with Richardson's syndrome phenotype (106), MSA of the cerebellar type (21), and MSA of the Parkinsonian type (60), ..
  32. Burson A, Matthijs H, de Bruijne W, Talens R, Hoogenboom R, Gerssen A, et al. Termination of a toxic Alexandrium bloom with hydrogen peroxide. Harmful Algae. 2014;31:125-135 pubmed publisher
    ..ostenfeldii is a well-known harmful algal species that can potentially cause paralytic shellfish poisoning (PSP). Usually A...
  33. Comelli I, Bologna A, Ticinesi A, Magnacavallo A, Comelli D, Meschi T, et al. Incidence of primary spontaneous pneumothorax is not associated with microclimatic variations. Results of a seven-year survey in a temperate climate area. Monaldi Arch Chest Dis. 2017;87:793 pubmed publisher
    ..In particular, despite a correlation has been reported between incidence of primary spontaneous pneumothorax (PSP) and meteorological variations, the evidence remains poor and conflictual...
  34. Marras C, Cunningham C, Hou J, Proudfoot J, Standaert D, Juncos J, et al. Anti-inflammatory drug use and progressive supranuclear palsy. Parkinsonism Relat Disord. 2018;48:89-92 pubmed publisher
    ..We examined the association between NSAID use and risk of PSP, disease severity and age at onset...
  35. Kim J, McCann C. Communication impairments in people with progressive supranuclear palsy: A tutorial. J Commun Disord. 2015;56:76-87 pubmed publisher
    Progressive supranuclear palsy (PSP) is a progressive neurological condition, whose main features include supranuclear gaze palsy, frequent falls, bradykinesia, axial rigidity, cognitive decline and communication impairments...
  36. Roy R, Niccolini F, Pagano G, Politis M. Cholinergic imaging in dementia spectrum disorders. Eur J Nucl Med Mol Imaging. 2016;43:1376-86 pubmed publisher
    ..Thalamic AChE is significantly reduced in progressive supranuclear palsy (PSP) and multiple system atrophy, whilst it is not affected in PD...
  37. Tarn W, Kuo H, Yu H, Liu S, Tseng C, Dhananjaya D, et al. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Mol Biol Cell. 2016;27:1676-83 pubmed publisher
    ..RBM4 also has been implicated in neurogenesis in the mouse embryonic brain. Using mouse embryonal carcinoma P19 cells as a neural differentiation model, we observed a temporal correlation between RBM4 expression and a change in ..
  38. Watson H, Wehenkel S, Matthews J, Ager A. SHP-1: the next checkpoint target for cancer immunotherapy?. Biochem Soc Trans. 2016;44:356-62 pubmed publisher
    ..protein tyrosine phosphatase 1 (SHP-1) is a widely expressed inhibitory protein tyrosine phosphatase (PTP). In T-cells, it is a negative regulator of antigen-dependent activation and proliferation...
  39. Xiao X, He Q, Yu L, Wang S, Li Y, Yang H, et al. Structure-based optimization of salt-bridge network across the complex interface of PTPN4 PDZ domain with its peptide ligands in neuroglioma. Comput Biol Chem. 2017;66:63-68 pubmed publisher
    The PTP non-receptor type 4 (PTPN4) is an important regulator protein in learning, spatial memory and cerebellar synaptic plasticity; targeting the PDZ domain of PTPN4 has become as attractive therapeutic strategy for human neuroglioma...
  40. Baev A, Elustondo P, Negoda A, Pavlov E. Osmotic regulation of the mitochondrial permeability transition pore investigated by light scattering, fluorescence and electron microscopy techniques. Anal Biochem. 2018;552:38-44 pubmed publisher
    ..b>PTP is caused by the opening of the large weakly selective channel...
  41. van Beelen Granlund A, Østvik A, Brenna Ø, Torp S, Gustafsson B, Sandvik A. REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. Cell Tissue Res. 2013;352:639-46 pubmed publisher
    ..All human family members, namely REG1A, REG1B, REG3A and REG4, are closely related in genomic sequence and all are part of the c-type lectin superfamily...
  42. Pillas M, Selai C, Quinn N, Lees A, Litvan I, Lang A, et al. Development and validation of a carers quality-of-life questionnaire for parkinsonism (PQoL Carers). Qual Life Res. 2016;25:81-8 pubmed publisher
    ..a survey in 282 carers of multiple system atrophy (MSA) patients and 226 carers of progressive supranuclear palsy (PSP) patients...
  43. Wang Y, Wu L, Wong T, Bauch M, Zhang Q, Zhang J, et al. Directional fluorescence emission co-enhanced by localized and propagating surface plasmons for biosensing. Nanoscale. 2016;8:8008-16 pubmed publisher
    We investigated the simultaneous excitation of localized surface plasmons (LSPs) and propagating surface plasmons (PSPs) on a thin metallic film with an array of nanoholes for the enhancement of fluorescence intensity in heterogeneous ..
  44. Chen G, Le Y, Zhou L, Gong L, Li X, Li Y, et al. Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23. PLoS ONE. 2016;11:e0153288 pubmed publisher
    ..the protein levels of IL-12 and IL-23 in the culture medium and the mRNA levels of IL-12 p35, IL-12 p40 and IL-23 p19 in the DCs all decreased in dexmedetomidine group (P<0.05)...
  45. El Khlousy M, Rahman E, Mostafa S, Bassam A, Elgawad H, Elnasr M, et al. Study of the clinical relevance of Helicobacter pylori virulence genes to gastric diseases among Egyptian patients. Arab J Gastroenterol. 2016;17:90-4 pubmed publisher
    ..pylori (cagA, vacA, P25, and P19) IgG antibodies by immunoblot assay were done. H. pylori infection was detected in 23 (62...
  46. Chiu C, Yeh T, Lai S, Weng Y, Huang Y, Cheng Y, et al. Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease. Oncotarget. 2016;7:54215-54227 pubmed publisher
    ..patients compared with matched control subjects and other parkinsonian disorders, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA)...
  47. Qu M, Fang F, Zou X, Zeng Q, Fan Z, Chen L, et al. miR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19INK4D. Cell Death Dis. 2016;7:e2430 pubmed publisher
    ..Real-time PCR, western blot and luciferase reporter assay reveal that p19INK4D is a direct target of miR-125b...
  48. García Saldivia M, Ilarraza Lomelí H, Myers J, Lara J, Bueno L. Effect of physical training on the recovery of acute exercise, among patients with cardiovascular disease. Arch Cardiol Mex. 2017;87:199-204 pubmed publisher
    Physical training programs (PTP) have shown several beneficial effects for patients with cardiovascular disease (CVD), particularly by increasing survival and quality of life...
  49. Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, et al. Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. J Neurosci. 2017;37:7125-7139 pubmed publisher
    ..We here show that PTP-3, a LAR homolog in Caenorhabditis elegans, is involved in axon guidance regulated by Semaphorin-2A-..
  50. Schaar K, Geisler A, Kraus M, Pinkert S, Pryshliak M, Spencer J, et al. Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters. Mol Ther Nucleic Acids. 2017;8:300-316 pubmed publisher
    ..In vitro evaluation of amiRs targeting the E1A, pTP, IVa2, and hexon genes of hAd5 revealed that two scAAV vectors containing three copies of amiR-pTP and three copies ..
  51. Lazo J, McQueeney K, Burnett J, Wipf P, Sharlow E. Small molecule targeting of PTPs in cancer. Int J Biochem Cell Biol. 2018;96:171-181 pubmed publisher
    ..viewed as privileged drug targets, and progress on identifying potent, selective, and cell-active small molecule PTP inhibitors has suffered accordingly...
  52. Zhu J. Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer. J Thorac Dis. 2017;9:2974-2981 pubmed publisher
    Pulmonary sclerosing pneumocytoma (PSP) is a rare benign lung tumor. This study investigated the diagnostic experience of PSP and lung cancer.
  53. Chen S, Lau P, Lei M, Peng J, Tang T, Wang X, et al. Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model. J Tissue Eng Regen Med. 2017;11:34-43 pubmed publisher
    ..We subsequently tested combined scaffolds of PLGA-TCP-P-S-P-chitosan (P/T/PSP-chitosan) made of P/T/P-chitosan and P/T/S-chitosan to assess their integral effect, on enhancement of bone ..
  54. Kikuchi M, Nishizaki Y, Tsuruya K, Hamada I, Higashi T, Sakuma K, et al. Acute portal vein thrombosis due to chronic relapsing pancreatitis: a fistula between a pancreatic pseudocyst and the splenic vein. Clin J Gastroenterol. 2014;7:52-7 pubmed publisher
    ..Although we were able to successfully catheterize the percutaneous transhepatic portal vein (PTP), we could not achieve recanalization of the portal vein...
  55. Park I, Chung Jung D, Suk Hyun Hwang S, Yeon Jung H, Yoon J, Kim C, et al. Longitudinal relationship between Personal and Social Performance (PSP) and anxiety symptoms in schizophrenia. J Affect Disord. 2016;190:12-18 pubmed publisher
    ..anxiety subscale in the SCL-90-R, we applied latent growth model to determine the causal relationship between the PSP and the anxiety symptoms...
  56. Khataee A, Gholami P, Vahid B. Heterogeneous sono-Fenton-like process using nanostructured pyrite prepared by Ar glow discharge plasma for treatment of a textile dye. Ultrason Sonochem. 2016;29:213-25 pubmed publisher
    The plasma-treated pyrite (PTP) nanostructures were prepared from natural pyrite (NP) utilizing argon plasma due to its sputtering and cleaning effects resulting in more active surface area...
  57. Santangeli P, Hutchinson M, Supple G, Callans D, Marchlinski F, Garcia F. Right Atrial Approach for Ablation of Ventricular Arrhythmias Arising From the Left Posterior-Superior Process of the Left Ventricle. Circ Arrhythm Electrophysiol. 2016;9: pubmed publisher
    The posterior-superior process of the left ventricle (PSP-LV) is the most inferior and posterior aspect of the basal LV that extends posteriorly to the plane of the tricuspid valve...
  58. Eusebio A, Koric L, Felician O, Guedj E, Ceccaldi M, Azulay J. Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations. Rev Neurol (Paris). 2016;172:488-502 pubmed publisher
    Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are two atypical parkinsonian syndromes first described half a century ago...
  59. Giorgio V, Guo L, Bassot C, Petronilli V, Bernardi P. Calcium and regulation of the mitochondrial permeability transition. Cell Calcium. 2018;70:56-63 pubmed publisher
    ..In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca2+ can reversibly switch this ..
  60. Boxer A, Yu J, Golbe L, Litvan I, Lang A, Höglinger G. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. Lancet Neurol. 2017;16:552-563 pubmed publisher
    Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau ..
  61. Fukui Y, Hishikawa N, Sato K, Yunoki T, Kono S, Matsuzono K, et al. Differentiating progressive supranuclear palsy from Parkinson's disease by MRI-based dynamic cerebrospinal fluid flow. J Neurol Sci. 2015;357:178-82 pubmed publisher
    The purpose of this study was to clarify the difference between PSP and PD from the viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct. Thirty-three PD patients (mean age 69.2±7...
  62. Krishnan B, Scott M, Pollandt S, SCHROEDER B, Kurosky A, Shinnick Gallagher P. Fear potentiated startle increases phospholipase D (PLD) expression/activity and PLD-linked metabotropic glutamate receptor mediated post-tetanic potentiation in rat amygdala. Neurobiol Learn Mem. 2016;128:65-79 pubmed publisher
    ..FPS Post-tetanic potentiation (PTP) immediately following long-term potentiation (LTP) induction was significantly increased...
  63. Torii S, Kubota C, Saito N, Kawano A, Hou N, Kobayashi M, et al. The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells. J Biol Chem. 2018;293:5920-5933 pubmed publisher
    ..The receptor-type PTP phogrin primarily localizes on insulin secretory granules in pancreatic β cells...
  64. Jang S, Javadov S. Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria. Arch Biochem Biophys. 2017;630:1-8 pubmed publisher
    ..Thus, PTP-dependent swelling of mitochondria solely depends on Ca2+ but not ROS...
  65. Grant G. Regulatory Mechanism of Mycobacterium tuberculosis Phosphoserine Phosphatase SerB2. Biochemistry. 2017;56:6481-6490 pubmed publisher
    ..The last enzyme in the pathway, phosphoserine phosphatase (PSP), has also been reported to be inhibited by l-serine...
  66. Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn J, Berge Lefranc J. A gene homologous to the reg gene is expressed in the human pancreas. FEBS Lett. 1993;327:289-93 pubmed
    We have determined the nucleotide sequence of regl a human genomic DNA fragment homologous to the reg gene which is expressed in the exocrine pancreas and regenerating islets...
  67. Nojehdehian H, Moztarzadeh F, Baharvand H, Mehrjerdi N, Nazarian H, Tahriri M. Effect of poly-L-lysine coating on retinoic acid-loaded PLGA microspheres in the differentiation of carcinoma stem cells into neural cells. Int J Artif Organs. 2010;33:721-30 pubmed
    ..Some microspheres were coated with poly-L-lysine (an extracellular matrix (ECM) component), and then pluripotent P19 embryonic carcinoma cells were seeded on them...
  68. Penafuerte C, Pérez Quintero L, Vinette V, Hatzihristidis T, Tremblay M. Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity. Curr Top Microbiol Immunol. 2017;410:191-214 pubmed publisher
    ..Several PTPs, including TC-PTP (PTPN2) and SHP-1 (PTPN6), have been recognized as being crucial for maintaining proper immune response and self-..
  69. Ghoncheh Z, Kheirandish Y, Kaviani H, Kharazi Fard M, Sadeghi K. Diagnosis of Approximal Caries after Delayed Scanning of Photostimulable Phosphor Plates. J Dent (Shiraz). 2017;18:201-206 pubmed
    Considering the high diagnostic accuracy and wide dynamic range of photostimulable phosphor plates (PSPs), they can be a good alternative for radiographic films.
  70. Fazal S, Gomez Sanchez J, Wagstaff L, Musner N, Otto G, Janz M, et al. Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination. J Neurosci. 2017;37:12297-12313 pubmed publisher
    ..The tumor suppressor P19ARF is strongly activated in the nerves of these mice and, even in aged c-Jun OE/OE mice, there is no ..
  71. He H, Wang Y, Song K, Wang J, Wei S, Zhao P, et al. [Cloning, expression, purification and structure analysis of protein tyrosine phosphatase of Bombyx mori]. Sheng Wu Gong Cheng Xue Bao. 2017;33:1827-1839 pubmed publisher
    Protein tyrosine phosphatase (PTP, EC 3.1.3...
  72. Lai Fook S, Hyatt R. Effects of age on elastic moduli of human lungs. J Appl Physiol (1985). 2000;89:163-8 pubmed
    ..the bulk modulus and shear modulus of human lungs obtained at autopsy at several fixed transpulmonary pressures (Ptp)...
  73. Sadovskaya I, Vinogradov E, Courtin P, Armalyte J, Meyrand M, Giaouris E, et al. Another Brick in the Wall: a Rhamnan Polysaccharide Trapped inside Peptidoglycan of Lactococcus lactis. MBio. 2017;8: pubmed publisher
    ..In Lactococcus lactis, a polysaccharide pellicle (PSP) forms a layer at the cell surface. The PSP structure varies among lactococcal strains; in L...
  74. Pellicano C, Assogna F, Cellupica N, Piras F, Pierantozzi M, Stefani A, et al. Neuropsychiatric and cognitive profile of early Richardson's syndrome, Progressive Supranuclear Palsy-parkinsonism and Parkinson's disease. Parkinsonism Relat Disord. 2017;45:50-56 pubmed publisher
    The two main variants of Progressive Supranuclear Palsy (PSP), Richardson's syndrome (PSP-RS) and PSP-parkinsonism (PSP-P), share motor and non-motor features with Parkinson's disease (PD) particularly in the early stages...
  75. Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De caro A. Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein. Biochem J. 1986;238:227-32 pubmed
    Pancreatic stone protein (PSP) is the major organic component of human pancreatic stones...
  76. De Caro A, Bonicel J, Rouimi P, De Caro J, Sarles H, Rovery M. Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. Eur J Biochem. 1987;168:201-7 pubmed
    ..The protein studied was the lowest-Mr form prepared from human pancreatic juice (PSP S1). The N-terminal sequence up to residue 65 had already been determined...
  77. Quinn M, Spinosa E, Roberts D. Miniaturisation of Pressure-Sensitive Paint Measurement Systems Using Low-Cost, Miniaturised Machine Vision Cameras. Sensors (Basel). 2017;17: pubmed publisher
    Measurements of pressure-sensitive paint (PSP) have been performed using new or non-scientific imaging technology based on machine vision tools...
  78. Kjær J, Belsham G. Selection of functional 2A sequences within foot-and-mouth disease virus; requirements for the NPGP motif with a distinct codon bias. RNA. 2018;24:12-17 pubmed publisher
    ..Indeed, the codons selected to code for P17 and P19 within this motif were distinct; thus the synonymous codons are not equivalent. ..
  79. Rouimi P, De Caro J, Bonicel J, Rovery M, De caro A. The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice. FEBS Lett. 1988;229:171-4 pubmed
    Following the complete sequence elucidation of human pancreatic stone protein (immunoreactive form PSP S1 isolated from pancreatic juice) [(1987) Eur. J. Biochem...
  80. Möck M, Schwarz C, Thier P. Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons. J Neurophysiol. 2002;88:549-64 pubmed
    ..In addition, application of 5 microM 5-HT also modulated postsynaptic potentials (PSPs) evoked by electric stimulations within the cerebral peduncle...
  81. Ochiai K, Kaneko K, Kitagawa M, Ando H, Hayakawa T. Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts. Dig Dis Sci. 2004;49:1953-6 pubmed
    ..However, the mechanism of protein plug formation remains unknown. Pancreatic stone protein (PSP) is reported to be a key protein to form protein plugs in chronic pancreatitis...
  82. Dale M, Horak F, Wright W, Schoneburg B, Nutt J, Mancini M. Impaired perception of surface tilt in progressive supranuclear palsy. PLoS ONE. 2017;12:e0173351 pubmed publisher
    Progressive supranuclear palsy (PSP) is characterized by early postural instability and backward falls. The mechanisms underlying backward postural instability in PSP are not understood...
  83. Shin H, Li Z, Kim E, Park J, Lim W. Which species, Alexandrium catenella (Group I) or A. pacificum (Group IV), is really responsible for past paralytic shellfish poisoning outbreaks in Jinhae-Masan Bay, Korea?. Harmful Algae. 2017;68:31-39 pubmed publisher
    Paralytic shellfish poisoning (PSP) caused the deaths of four people in coastal area of Korea, mainly Jinhae-Masan Bay and adjacent areas, in April 1986 and in 1996...
  84. Cho S, Jheon S, Kim D, Kim H, Huh D, Lee S, et al. Results of repeated video-assisted thoracic surgery for recurrent pneumothorax after primary spontaneous pneumothorax. Eur J Cardiothorac Surg. 2017;: pubmed publisher
    ..study aimed to identify the causes of recurrent pneumothorax and to evaluate the results of repeated video-assisted thoracic surgery (VATS) for recurrent pneumothorax after VATS wedge resection for primary spontaneous pneumothorax (PSP).
  85. Yu J, Zhu L, Xia S, Li H, Tang Y, Liang X, et al. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnol Bioeng. 2016;113:1531-41 pubmed publisher
    ..Co-expression of sbtA, bicA, and ppc with weak promoter P4 and pck with strong promoter P19 (AFP111/pT-P4 -bicA-P4 -sbtA + pACYC-P19 -pck-P4 -ppc) provided the best succinate production among ..
  86. Constantinides V, Paraskevas G, Emmanouilidou E, Petropoulou O, Bougea A, Vekrellis K, et al. CSF biomarkers ?-amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes. J Neurol Sci. 2017;382:91-95 pubmed publisher
    Differential diagnosis of Parkinson-plus patients (PSP, CBD, MSA) and Parkinson's disease (PD) patients is often not straightforward, particularly in atypical cases or at the initial stages of the diseases...
  87. Constantinides V, Paraskevas G, Stamboulis E, Kapaki E. Simple linear brainstem MRI measurements in the differential diagnosis of progressive supranuclear palsy from the parkinsonian variant of multiple system atrophy. Neurol Sci. 2018;39:359-364 pubmed publisher
    Differential diagnosis of progressive supranuclear palsy (PSP) and the parkinsonian variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) can be difficult, particularly in atypical cases or early in the disease course...
  88. Klein H, Csordas A, Falk V, Slankamenac K, Rudiger A, Schönrath F, et al. Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique. PLoS ONE. 2015;10:e0120276 pubmed publisher
    We investigated the role of pancreatic stone protein (PSP) in predicting the occurrence of infection in the postoperative course of cardiac surgery patients...
  89. Ou S, Weitz M, Jalas J, Kelly D, Wong V, Azada M, et al. Alectinib induced CNS radiation necrosis in an ALK+NSCLC patient with a remote (7 years) history of brain radiation. Lung Cancer. 2016;96:15-8 pubmed publisher
    ..Pseudoprogression (PsP) due to radiation necrosis during alecitnib treatment of central nervous system (CNS) metastases from ALK-..
  90. Douanla Meli C, Unger J, Langer E. Multi-approach analysis of the diversity in Colletotrichum cliviae sensu lato. Antonie Van Leeuwenhoek. 2018;111:423-435 pubmed publisher
    ..by using the coalescent method of the generalized mixed Yule-coalescent (GMYC) and Poisson Tree Processes (PTP). Single and multilocus gene trees strongly supported a C. cliviae s. lat. clade including the four species...
  91. Wang D, Liu C, Wang Y, Wang W, Wang K, Wu X, et al. Impact of miR-26b on cardiomyocyte differentiation in P19 cells through regulating canonical/non-canonical Wnt signalling. Cell Prolif. 2017;50: pubmed publisher
    ..Here, we evaluated the impact of miR-26b during the progression of cardiomyocyte differentiation from the P19 cell line. The overexpression of miR-26b in P19 cells was performed by transduction with lentivirus vector...
  92. Sui Y, Fu X, Wang Y, Hu W, Zhang T, Liu W, et al. Expression, purification and characterization of a catalytic domain of human protein tyrosine phosphatase non-receptor 12 (PTPN12) in Escherichia coli with FKBP-type PPIase as a chaperon. Protein Expr Purif. 2018;142:45-52 pubmed publisher
    Protein tyrosine phosphatase non-receptor type 12 (PTPN12), also known as PTP-PEST, was broadly expressed in hemopoietic cells...