RECQL5

Summary

Gene Symbol: RECQL5
Description: RecQ like helicase 5
Alias: RECQ5, ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RecQ helicase-like 5, RecQ protein-like 5
Species: human
Products:     RECQL5

Top Publications

  1. Blundred R, Myers K, Helleday T, Goldman A, Bryant H. Human RECQL5 overcomes thymidine-induced replication stress. DNA Repair (Amst). 2010;9:964-75 pubmed publisher
    ..Here, we have studied the role of RECQL5, which is the least characterised of the five human RecQ helicases...
  2. Shimamoto A, Nishikawa K, Kitao S, Furuichi Y. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res. 2000;28:1647-55 pubmed
    ..At least five human RecQ-related genes exist: RecQ1, BLM, WRN, RecQ4 and RecQ5. Mutations in BLM, WRN and RecQ4 are associated with Bloom, Werner and Rothmund-Thomson syndromes, respectively, ..
  3. Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, et al. Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell. 2012;23:4273-85 pubmed publisher
    Human RECQL5 is a member of the RecQ helicase family, which maintains genome stability via participation in many DNA metabolic processes, including DNA repair. Human cells lacking RECQL5 display chromosomal instability...
  4. Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, et al. Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem. 2010;285:15739-45 pubmed publisher
    ..In mammalian cells, several DNA helicases have been implicated in the regulation of this process. RECQ5, a member of the RecQ family of DNA helicases, interacts physically with the RAD51 recombinase and disrupts RAD51 ..
  5. Ramamoorthy M, Tadokoro T, Rybanska I, Ghosh A, Wersto R, May A, et al. RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression. Nucleic Acids Res. 2012;40:1621-35 pubmed publisher
    ..Here, we report a physical and functional interaction of Topoisomerase II? with RECQL5, one of five mammalian RecQ helicases, during DNA replication...
  6. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. Genomics. 1998;54:443-52 pubmed
    Two new human DNA helicase genes, RecQ4 and RecQ5, that belong to the RecQ helicase family were cloned and characterized...
  7. Hu Y, Raynard S, Sehorn M, Lu X, Bussen W, Zheng L, et al. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 2007;21:3073-84 pubmed
    ..RECQL and RECQL5 have not been associated with a human disease...
  8. Popuri V, Ramamoorthy M, Tadokoro T, Singh D, Karmakar P, Croteau D, et al. Recruitment and retention dynamics of RECQL5 at DNA double strand break sites. DNA Repair (Amst). 2012;11:624-35 pubmed publisher
    b>RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and Bloom syndrome proteins (BLM), little is known about RECQL5...
  9. Islam M, Paquet N, Fox D, Dray E, Zheng X, Klein H, et al. A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization. J Biol Chem. 2012;287:23808-18 pubmed publisher
    ..Here, we identified a BRC repeat variant, named BRCv, in the RECQL5 helicase, which possesses anti-recombinase activity in vitro and suppresses HR and promotes cellular resistance to ..

More Information

Publications73

  1. Sekelsky J, Brodsky M, Rubin G, Hawley R. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. Nucleic Acids Res. 1999;27:3762-9 pubmed
    ..only a single member of this family, there are at least five human RecQ-related genes: RecQL, BLM, WRN, RecQ4 and RecQ5. Mutations in at least three of these are associated with diseases involving a predisposition to malignancies and ..
  2. Li M, Xu X, Liu Y. The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 2011;31:2090-9 pubmed publisher
    The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells...
  3. Izumikawa K, Yanagida M, Hayano T, Tachikawa H, Komatsu W, Shimamoto A, et al. Association of human DNA helicase RecQ5beta with RNA polymerase II and its possible role in transcription. Biochem J. 2008;413:505-16 pubmed publisher
    ..Knockdown of the RecQ5beta transcript increased the transcription of those genes. The results of the present study suggest that RecQ5beta has suppressive roles in events associated with RNAP II-dependent transcription. ..
  4. Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau D, Bohr V. RECQL5 plays co-operative and complementary roles with WRN syndrome helicase. Nucleic Acids Res. 2013;41:881-99 pubmed publisher
    ..Here we show that RECQL5 associates longer at laser-induced DNA double-strand breaks in the absence of Werner syndrome (WRN) protein, and ..
  5. Aygün O, Svejstrup J, Liu Y. A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Proc Natl Acad Sci U S A. 2008;105:8580-4 pubmed publisher
    ..Our data establish RECQ5 helicase as a bona fide RNAPII-associated protein...
  6. Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al. MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 2009;37:2645-57 pubmed publisher
    b>RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments...
  7. Aygün O, Xu X, Liu Y, Takahashi H, Kong S, Conaway R, et al. Direct inhibition of RNA polymerase II transcription by RECQL5. J Biol Chem. 2009;284:23197-203 pubmed publisher
    ..Although progress has been made in understanding the biochemical role of some human RECQ helicases, that of RECQL5 remains elusive...
  8. Speina E, Dawut L, Hedayati M, Wang Z, May A, Schwendener S, et al. Human RECQL5beta stimulates flap endonuclease 1. Nucleic Acids Res. 2010;38:2904-16 pubmed publisher
    Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk...
  9. Islam M, Fox D, Guo R, Enomoto T, Wang W. RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol. 2010;30:2460-72 pubmed publisher
    The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. To elucidate its mechanism of action, we purified a RecQL5-associated complex and identified its major component as RNA polymerase II (Pol II)...
  10. Kanagaraj R, Saydam N, Garcia P, Zheng L, Janscak P. Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res. 2006;34:5217-31 pubmed
    ..Loss of such activity could explain the elevated level of mitotic crossovers observed in RECQ5beta-deficient cells. ..
  11. Garcia P, Liu Y, Jiricny J, West S, Janscak P. Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J. 2004;23:2882-91 pubmed
    ..This is the first demonstration of a DNA helicase with an intrinsic DNA strand-annealing function residing in a separate domain. ..
  12. Ren H, Dou S, Zhang X, Wang P, Kanagaraj R, Liu J, et al. The zinc-binding motif of human RECQ5beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme. Biochem J. 2008;412:425-33 pubmed publisher
    ..The novel intramolecular modulation of RECQ5beta catalytic activity mediated by the zinc-binding motif may represent a universal regulation mode for all RecQ family helicases. ..
  13. Rebehmed J, Revy P, Faure G, de Villartay J, Callebaut I. Expanding the SRI domain family: a common scaffold for binding the phosphorylated C-terminal domain of RNA polymerase II. FEBS Lett. 2014;588:4431-7 pubmed publisher
    ..three-helix domain originally discovered near the C-terminus of both histone methyltransferase SETD2 and helicase RECQL5. The SRI domain binds to the C-terminal repeat domain of the largest subunit of RNA polymerase II, allowing SETD2 ..
  14. Das R, Kundu S, Laskar S, Choudhury Y, Ghosh S. Assessment of DNA repair susceptibility genes identified by whole exome sequencing in head and neck cancer. DNA Repair (Amst). 2018;66-67:50-63 pubmed publisher
    ..05) with the risk (OR?>?5), while intronic variants in PARP4, RECQL5, EXO1 and PER1 genes and exonic variant in TDP2 gene showed protection (OR?<?1) for HNC...
  15. Zhu X, Chen H, Yang Y, Xu C, Zhou J, Zhou J, et al. Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer. Cancer Manag Res. 2018;10:6649-6668 pubmed publisher
    ..Increased expression of RECQL5 mRNA was associated with improved RFS in all patients, and with improved OS in patients with lymph-node-..
  16. Mirabello L, Yu K, Kraft P, De Vivo I, Hunter D, Prescott J, et al. The association of telomere length and genetic variation in telomere biology genes. Hum Mutat. 2010;31:1050-8 pubmed publisher
    ..Thirteen SNPs from four genes (MEN1, MRE11A, RECQL5, and TNKS) were significantly associated with telomere length. The strongest findings were in MEN1 (gene-based P=0...
  17. Kim T, Son M, Dodds S, Hu L, Luo G, Hasty P. RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. Nucleic Acids Res. 2015;43:893-903 pubmed publisher
    ..Two RecQ helicases, RECQL5 and Bloom syndrome mutated (BLM) suppress HR through nonredundant mechanisms...
  18. Rossi M, Ghosh A, Kulikowicz T, Croteau D, Bohr V. Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst). 2010;9:796-804 pubmed publisher
    ..conserved RecQ helicase family: RecQ1, Bloom syndrome protein (BLM), Werner syndrome protein (WRN), RecQ4, and RecQ5, which are all known for their roles in maintaining genome stability...
  19. Karantanos T, Moliterno A. The roles of JAK2 in DNA damage and repair in the myeloproliferative neoplasms: Opportunities for targeted therapy. Blood Rev. 2018;32:426-432 pubmed publisher
    ..the other hand, JAK2 signaling normally induces DDR through activation of repair mediators such as Chk1, RAD51 and RECQL5. These opposing effects on DNA integrity in the setting of JAK2V617F have significant clinical implications and ..
  20. Wu Y, Brosh R. Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst). 2010;9:315-24 pubmed publisher
    Five human RecQ helicases (WRN, BLM, RECQ4, RECQ5, RECQ1) exist in humans. Of these, three are genetically linked to diseases of premature aging and/or cancer. Neither RECQ1 nor RECQ5 has yet been implicated in a human disease...
  21. Budhathoki J, Ray S, Urban V, Janscak P, Yodh J, Balci H. RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Res. 2014;42:11528-45 pubmed publisher
    ..Finally, we show that while WRN has similar activity as BLM, RecQ and RECQ5 helicases do not unfold GQ in the absence of ATP at physiological ionic strength...
  22. Hu Y, Lu X, Zhou G, Barnes E, Luo G. Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment. Mol Biol Cell. 2009;20:114-23 pubmed publisher
    ..Here, we report that the deletion of RecQ helicase Recql5 in mouse ES cells and embryonic fibroblast (MEF) cells resulted in a significant increase in CPT sensitivity and a ..
  23. Sakurai H, Takai S, Kawamura K, Ogura Y, Yoshioka Y, Kawasaki K. Drosophila RecQ5 is involved in proper progression of early spermatogenesis. Biochem Biophys Res Commun. 2014;452:1071-7 pubmed publisher
    ..The human RECQL5 gene is expressed ubiquitously in almost all tissues, with strong expression in the testes (Shimamoto et al...
  24. Zhang R, Jia T, Lian F, Liu J, Zhou M. [Preparation, characterization and application of monoclonal antibody against RecQ helicase]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:169-174 pubmed
    ..Immunofluorescence was used to detect the interactions of mAb with BLM, RecQ4 and RecQ5 helicases in human breast cancer MDA-MB-231 cells...
  25. Li M, Xu X, Chang C, Zheng L, Shen B, Liu Y. SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts. Nat Commun. 2018;9:2706 pubmed publisher
    ..SUMO3, to the essential replication factor PCNA is induced on transcribed chromatin by the RNAPII-bound helicase RECQ5. Proteomic analysis reveals that SUMO2-PCNA enriches histone chaperones CAF1 and FACT in the replication complex ..
  26. Croteau D, Singh D, Hoh Ferrarelli L, Lu H, Bohr V. RECQL4 in genomic instability and aging. Trends Genet. 2012;28:624-31 pubmed publisher
    ..Humans have five members of this family: WRN, BLM, RECQL4, RECQL1, and RECQL5. The first three of are associated with premature aging and cancer prone syndromes, but the latter two proteins ..
  27. Garige M, Sharma S. Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure. Int J Toxicol. 2014;33:373-81 pubmed publisher
    The 5 known RecQ helicases in humans (RECQ1, BLM, WRN, RECQL4, and RECQ5) have demonstrated roles in diverse genome maintenance mechanisms but their functions in safeguarding the genome from environmental toxicants are poorly understood...
  28. Rossi M, Ghosh A, Bohr V. Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst). 2010;9:331-44 pubmed publisher
    ..The conserved RecQ family also includes RecQ1, Bloom syndrome protein (BLM), RecQ4, and RecQ5 in humans, as well as Sgs1 in Saccharomyces cerevisiae, Rqh1 in Schizosaccharomyces pombe, and homologs in ..
  29. Veith S, Mangerich A. RecQ helicases and PARP1 team up in maintaining genome integrity. Ageing Res Rev. 2015;23:12-28 pubmed publisher
    ..RecQL helicases (i.e., RECQL1, WRN, BLM, RECQL4, RECQL5) as well as poly(ADP-ribose) polymerases (PARPs, in particular PARP1) represent two central quality control ..
  30. Kim H, Suga K, Kim B, Rhee J, Lee J, Hagiwara A. Light-dependent transcriptional events during resting egg hatching of the rotifer Brachionus manjavacas. Mar Genomics. 2015;20:25-31 pubmed publisher
    ..In the 4h illuminated group, the RecQ protein-like 5 (RECQL5) gene was enriched...
  31. Fu W, Ligabue A, Rogers K, Akey J, Monnat R. Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases. Hum Mutat. 2017;38:193-203 pubmed publisher
    ..with computational prediction, identified over 300 potentially pathogenic population variants in RECQL and RECQL5, the two RECQ helicases that are not yet linked to a heritable deficiency syndrome...
  32. Mojumdar A, De March M, Marino F, Onesti S. The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity. J Biol Chem. 2017;292:4176-4184 pubmed publisher
    ..Five paralogues (RecQ1, Bloom, Werner, RecQ4, and RecQ5) are found in human cells, with distinct but overlapping roles...
  33. Ali R, Rakha E, Madhusudan S, Bryant H. DNA damage repair in breast cancer and its therapeutic implications. Pathology. 2017;49:156-165 pubmed publisher
    ..specific DNA damage response defects in breast cancer and to present the current stage of development of various DDR inhibitors (namely PARP, ATM/ATR, DNA-PK, PARG, RECQL5, FEN1 and APE1) for breast cancer mono- and combination therapy.
  34. Kantidakis T, Saponaro M, Mitter R, Horswell S, Kranz A, Boeing S, et al. Mutation of cancer driver MLL2 results in transcription stress and genome instability. Genes Dev. 2016;30:408-20 pubmed publisher
    ..Interestingly, MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate ..
  35. Green A, Aleskandarany M, Ali R, Hodgson E, Atabani S, De Souza K, et al. Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers. Cancer Immunol Res. 2017;5:292-299 pubmed publisher
    ..of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO2A, DNA-PKcs, Ku70/Ku80), nucleotide excision repair (ERCC1), base excision repair (XRCC1, pol ?, FEN1, PARP1)..
  36. Liao W, Qi Y, Wang L, Dong X, Xu T, Ding C, et al. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. World J Gastroenterol. 2015;21:10375-84 pubmed publisher
    To investigate the effects of Recql5 deficiency on liver injury induced by lipopolysaccharide/D-galactosamine (LPS/D-Gal)...
  37. Alsubhi N, Middleton F, Abdel Fatah T, Stephens P, Doherty R, Arora A, et al. Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer. Mol Oncol. 2016;10:213-23 pubmed publisher
    ..non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence...
  38. Urban V, Dobrovolna J, Hühn D, Fryzelkova J, Bartek J, Janscak P. RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. J Cell Biol. 2016;214:401-15 pubmed publisher
    Collisions between replication and transcription machineries represent a significant source of genomic instability. RECQ5 DNA helicase binds to RNA-polymerase (RNAP) II during transcription elongation and suppresses transcription-..
  39. Shamanna R, Lu H, Croteau D, Arora A, Agarwal D, Ball G, et al. Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer. Oncotarget. 2016;7:13269-84 pubmed publisher
    ..The five human RecQ helicases, RECQL1, Bloom, WRN, RECQL4 and RECQL5 play critical roles in DNA repair and cell survival after treatment with the anticancer drug camptothecin (CPT)...
  40. Khadka P, Croteau D, Bohr V. RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. DNA Repair (Amst). 2016;37:53-66 pubmed publisher
    ..b>RECQL5 possesses relatively strong annealing activity on long or small duplexed substrates compared to the other RecQs...
  41. Wang X, Lu X, Zhou G, Lou H, Luo G. RECQL5 is an important determinant for camptothecin tolerance in human colorectal cancer cells. Biosci Rep. 2011;31:363-9 pubmed publisher
    ..In the present study, we examined whether RECQL5 constitutes an important determinant of CPT resistance in colon cancer cells...
  42. Budhathoki J, Maleki P, Roy W, Janscak P, Yodh J, Balci H. A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase. Biophys J. 2016;110:2585-2596 pubmed publisher
    b>RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (BLM), Werner (WRN), RECQ4, and RECQ5. Both WRN and BLM have been shown to resolve G-quadruplex (GQ) structures...
  43. Arora A, Abdel Fatah T, Agarwal D, Doherty R, Croteau D, Moseley P, et al. Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers. Carcinogenesis. 2016;37:63-71 pubmed publisher
    b>RECQL5 is a member of the RecQ family of DNA helicases and has key roles in homologous recombination, base excision repair, replication and transcription...
  44. Li M, Pokharel S, Wang J, Xu X, Liu Y. RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat Commun. 2015;6:6720 pubmed publisher
    ..b>RECQ5 helicase promotes TOP1 SUMOylation by facilitating the interaction between PIAS1, SRSF1 and TOP1...
  45. PATTERSON K, Arya L, Bottomley S, Morgan S, Cox A, Catto J, et al. Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy. Oncotarget. 2016;7:76140-76150 pubmed publisher
    ..human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5...
  46. Yadav A, Thakur J, Yadav G. KIXBASE: A comprehensive web resource for identification and exploration of KIX domains. Sci Rep. 2017;7:14924 pubmed publisher
    ..the p300/CBP (a histone acetyl transferase), MED15 (a subunit of the mediator complex of RNA polymerase II), and RECQL5 helicases...
  47. Zhi L, Ma W, Zhang H, Zeng S, Chen B. Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population. Tumour Biol. 2014;35:3255-9 pubmed publisher
    ..We selected three polymorphisms of the RECQL5 gene (rs820196, rs820200, and rs4789223) in the present study...
  48. Popuri V, Tadokoro T, Croteau D, Bohr V. Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability. Crit Rev Biochem Mol Biol. 2013;48:289-99 pubmed publisher
    ..The biological role of human RECQL5 is only partially understood and RECQL5 has not yet been associated with any human disease...
  49. Mo D, Zhao Y, Balajee A. Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. Cancer Lett. 2018;413:1-10 pubmed publisher
    ..Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes characterized by accelerated aging symptoms and cancer incidence...
  50. Hosono Y, Abe T, Ishiai M, Islam M, Arakawa H, Wang W, et al. Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents. Biochim Biophys Acta. 2014;1843:1002-12 pubmed publisher
    RecQ family DNA helicases function in the maintenance of genome stability. Mice deficient in RecQL5, one of five RecQ helicases, show a cancer predisposition phenotype, suggesting that RecQL5 plays a tumor suppressor role...
  51. Leparc G, Mitra R. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Nucleic Acids Res. 2007;35:3192-202 pubmed
    ..Overall, PASE was able to uncover 59 novel alternative cassette exons in C. elegans and humans through a genome-wide ab initio prediction method that enriches for exons involved in signaling. ..
  52. Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, et al. Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities. Mol Cell Biol. 2015;35:3974-89 pubmed publisher
    ..Furthermore, we define the effects that PARP1, PARylated PARP1, and PAR have on RECQL5 and WRN, using both in vitro and in vivo assays...
  53. Dong Y, Huang Y, Lu T. Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population. Genet Mol Res. 2015;14:1899-902 pubmed publisher
    ..We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls...
  54. Chen E, Ahn J, Sykes D, Breyfogle L, Godfrey A, Nangalia J, et al. RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability. Cell Rep. 2015;13:2345-2352 pubmed publisher
    ..In this study, we address this paradox by identifying the DNA helicase RECQL5 as a suppressor of genomic instability in MPNs...
  55. He Y, Qiao Z, Gao B, Zhang X, Wen Y. Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer. Tumour Biol. 2014;35:12201-4 pubmed publisher
    Previous studies indicated that the RECQL5 gene polymorphism was associated with human cancers. However, the association of RECQL5 gene polymorphism with breast cancer remains unclear...
  56. Xie X, Zheng Y, Adi D, Yang Y, Ma Y, Li X, et al. Exome Sequencing in a Family Identifies RECQL5 Mutation Resulting in Early Myocardial Infarction. Medicine (Baltimore). 2016;95:e2737 pubmed publisher
    ..We identified a mutation in the RECQL5 gene, 1 of the 5 members of the RECQ family which are involved in the maintenance of genomic stability...
  57. Wu J, Zhi L, Dai X, Cai Q, Ma W. Decreased RECQL5 correlated with disease progression of osteosarcoma. Biochem Biophys Res Commun. 2015;467:617-22 pubmed publisher
    Human RecQ helicase family, consisting of RECQL, RECQL4, RECQL5, BLM and WRN, has critical roles in genetic stability and tumorigenesis...
  58. Qi Y, Zhou X. Haplotype analysis of RECQL5 gene and laryngeal cancer. Tumour Biol. 2014;35:2669-73 pubmed publisher
    ..Four polymorphisms of the RECQL5 gene (rs820186, rs820196, rs820200, and rs4789223) were genotyped by the TaqMan method in 275 patients with larynx ..
  59. Ni Z, Olsen J, Guo X, Zhong G, Ruan E, Marcon E, et al. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription. 2011;2:237-42 pubmed publisher
    ..RPRD1B and RPRD2, which co-purify with RNAP II and three other RNAP II-associated proteins, RPAP2, GRINL1A and RECQL5, but not with the Mediator complex...
  60. Newman J, Aitkenhead H, Savitsky P, Gileadi O. Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5. Nucleic Acids Res. 2017;45:4231-4243 pubmed publisher
    ..b>RECQL5 is one of five human RecQ proteins and is particularly versatile in this regard, forming protein complexes with a ..
  61. Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell. 2017;66:658-671.e8 pubmed publisher
    ..Here, we show that these DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phosphorylation by CDK1...
  62. Kassube S, Jinek M, Fang J, Tsutakawa S, Nogales E. Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5. Nat Struct Mol Biol. 2013;20:892-9 pubmed publisher
    b>RECQL5 is a member of the highly conserved RecQ family of DNA helicases involved in DNA repair. RECQL5 interacts with RNA polymerase II (Pol II) and inhibits transcription of protein-encoding genes by an unknown mechanism...
  63. Paliwal S, Kanagaraj R, Sturzenegger A, Burdova K, Janscak P. Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Res. 2014;42:2380-90 pubmed publisher
    ..The molecular mechanisms controlling HR sub-pathway choice are poorly understood. Here, we show that human RECQ5, a DNA helicase that can disrupt RAD51 nucleoprotein filaments, promotes formation of non-crossover products ..
  64. Saponaro M, Kantidakis T, Mitter R, Kelly G, Heron M, Williams H, et al. RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress. Cell. 2014;157:1037-49 pubmed publisher
    b>RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription...