RECQL

Summary

Gene Symbol: RECQL
Description: RecQ like helicase
Alias: RECQL1, RecQ1, ATP-dependent DNA helicase Q1, DNA helicase, RecQ-like type 1, DNA-dependent ATPase Q1, RecQ helicase-like, RecQ protein-like (DNA helicase Q1-like), recQ protein-like 1
Species: human
Products:     RECQL

Top Publications

  1. Futami K, Kumagai E, Makino H, Goto H, Takagi M, Shimamoto A, et al. Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase. Cancer Sci. 2008;99:71-80 pubmed
    b>RecQL1 DNA helicase of the human RecQ helicase family participates in DNA repair and recombination pathways during cell-cycle replication...
  2. Seki M, Yanagisawa J, Kohda T, Sonoyama T, Ui M, Enomoto T. Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes. J Biochem. 1994;115:523-31 pubmed
    ..The DNA helicase activity of Q2 was about 150-fold higher than that of Q1, when compared with units of ATPase activity.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  3. Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, et al. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol. 2013;20:347-54 pubmed publisher
    ..combined biochemical and EM approaches with single-molecule DNA fiber analysis to identify a key role for human RECQ1 helicase in replication fork restart after TOP1 inhibition that is not shared by other human RecQ proteins...
  4. Popuri V, Croteau D, Brosh R, Bohr V. RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle. 2012;11:4252-65 pubmed publisher
    b>RECQ1 is the most abundant of the five human RecQ helicases, but little is known about its biological significance...
  5. Mendoza Maldonado R, Faoro V, Bajpai S, Berti M, Odreman F, Vindigni M, et al. The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation. Mol Cancer. 2011;10:83 pubmed publisher
    ..Current data show that the specific depletion of the human RECQ1 helicase leads to mitotic catastrophe in cancer cells and inhibition of tumor growth in mice...
  6. Li D, Liu H, Jiao L, Chang D, Beinart G, Wolff R, et al. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res. 2006;66:3323-30 pubmed
    ..We investigated the effect of six single nucleotide polymorphisms of the RecQ1, RAD54L, XRCC2, and XRCC3 genes on overall survival of 378 patients with pancreatic adenocarcinoma who were ..
  7. Mazina O, Rossi M, Deakyne J, Huang F, Mazin A. Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins. J Biol Chem. 2012;287:11820-32 pubmed publisher
    ..that the polarity of the displaced ssDNA strand of the joint molecules defines the polarity of BM of RAD54, BLM, RECQ1, and RuvAB...
  8. Futami K, Ogasawara S, Goto H, Yano H, Furuichi Y. RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma. Int J Mol Med. 2010;25:537-45 pubmed
    b>RecQL1 in the human RecQ DNA helicase family participates in DNA repair and recombination pathways in cell cycle replication...
  9. Popuri V, Bachrati C, Muzzolini L, Mosedale G, Costantini S, Giacomini E, et al. The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J Biol Chem. 2008;283:17766-76 pubmed publisher
    ..new substrates and have compared the substrate specificity of BLM with that of another human RecQ helicase, RECQ1. Our findings show that RECQ1 has a distinct substrate specificity compared with BLM...

More Information

Publications85

  1. Sharma S, Brosh R. Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS ONE. 2007;2:e1297 pubmed
    ..b>RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been ..
  2. Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, Niccolini B, et al. Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol. 2007;5:e20 pubmed
    ..Here, we describe two quaternary forms of the human RECQ1 helicase, higher-order oligomers consistent with pentamers or hexamers, and smaller oligomers consistent with ..
  3. Puranam K, Kennington E, Sait S, Shows T, Rochelle J, Seldin M, et al. Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue. Genomics. 1995;26:595-8 pubmed
    We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ...
  4. Thangavel S, Mendoza Maldonado R, Tissino E, Sidorova J, Yin J, Wang W, et al. Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. Mol Cell Biol. 2010;30:1382-96 pubmed publisher
    ..We show that only RECQ1 (also called RECQL or RECQL1) and RECQ4 (also called RECQL4) associate with replication origins in a cell cycle-regulated fashion in ..
  5. Sharma S, Sommers J, Choudhary S, Faulkner J, Cui S, Andreoli L, et al. Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem. 2005;280:28072-84 pubmed
    ..We have focused our attention on human RECQ1, a DNA helicase whose cellular functions remain largely uncharacterized...
  6. Bugreev D, Brosh R, Mazin A. RECQ1 possesses DNA branch migration activity. J Biol Chem. 2008;283:20231-42 pubmed publisher
    ..Five members of the RecQ family have been found in humans, including RECQ1, RECQ5, BLM, WRN, and RECQ4; the last three are associated with human diseases...
  7. Lucic B, Zhang Y, King O, Mendoza Maldonado R, Berti M, Niesen F, et al. A prominent ?-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Res. 2011;39:1703-17 pubmed publisher
    ..The crystal structure of a truncated catalytic core of the human RECQ1 helicase (RECQ1(49-616)) shows a prominent ?-hairpin, with an aromatic residue (Y564) at the tip, located in the C-..
  8. Li D, Frazier M, Evans D, Hess K, Crane C, Jiao L, et al. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol. 2006;24:1720-8 pubmed
    ..The RecQ1 A159C, RAD54L C157T, XRCC1 R194W, and ATM T77C genotypes had a significant effect on the overall survival with log-..
  9. LeRoy G, Carroll R, Kyin S, Seki M, Cole M. Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines. Nucleic Acids Res. 2005;33:6251-7 pubmed
    ..Much less is known about the processing of Holliday junctions in eukaryotes. Here, we identify RecQL1 as a predominant ATP-dependent, HJ branch migrator present in human nuclear extracts...
  10. Seki M, Miyazawa H, Tada S, Yanagisawa J, Yamaoka T, Hoshino S, et al. Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12. Nucleic Acids Res. 1994;22:4566-73 pubmed
    ..Analysis of the genomic DNA indicated the presence of a homologous gene in mouse cells. The DNA helicase Q1 gene was localized on the short arm of human chromosome 12 at 12p12. ..
  11. Cui S, Arosio D, Doherty K, Brosh R, Falaschi A, Vindigni A. Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res. 2004;32:2158-70 pubmed
    ..developed an efficient baculovirus expression system that allows us to obtain milligram quantities of recombinant RECQ1. Our gel filtration and dynamic light scattering experiments show that RECQ1 has an apparent molecular mass of 158 ..
  12. Doherty K, Sharma S, Uzdilla L, Wilson T, Cui S, Vindigni A, et al. RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem. 2005;280:28085-94 pubmed
    ..Although a human disease has not yet been genetically linked to a mutation in RECQ1, the prominent roles of RecQ helicases in the maintenance of genome stability suggest that RECQ1 helicase is ..
  13. Lu X, Parvathaneni S, Hara T, Lal A, Sharma S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer. 2013;12:29 pubmed publisher
    ..Among the five known RecQ homologs in humans, functions of RECQ1, the most abundant of all, are poorly understood...
  14. Puranam K, Blackshear P. Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ. J Biol Chem. 1994;269:29838-45 pubmed
    A potential human DNA helicase, RECQL, was partially purified from HeLa cells, and a cDNA encoding this protein was subsequently cloned from a HeLa library...
  15. Pike A, Shrestha B, Popuri V, Burgess Brown N, Muzzolini L, Costantini S, et al. Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A. 2009;106:1039-44 pubmed publisher
    ..We present a crystal structure of a truncated form of the human RECQ1 protein with Mg-ADP...
  16. Sharma S, Phatak P, Stortchevoi A, Jasin M, Larocque J. RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst). 2012;11:537-49 pubmed publisher
    b>RECQ1 is the most abundant RecQ homolog in humans but its functions have remained mostly elusive...
  17. Suntornthiticharoen P, Srila W, Chavalitshewinkoon Petmitr P, Limudomporn P, Yamabhai M. Characterization of recombinant malarial RecQ DNA helicase. Mol Biochem Parasitol. 2014;196:41-4 pubmed publisher
    ..The purified enzyme could efficiently unwind partial duplex DNA substrate in a 3' to 5' direction. The malarial RecQ1 could not unwind substrates with both 5' and 3' overhangs, those with a 5' overhang, or blunt-ended DNA duplexes...
  18. Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, et al. RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma. Cancer Res. 2011;71:4598-607 pubmed publisher
    b>RECQL1 and WRN proteins are RecQ DNA helicases that participate in suppression of DNA hyper-recombination and repair. In this study, we report evidence supporting their candidacy as cancer therapeutic targets...
  19. Kim H, Suga K, Kim B, Rhee J, Lee J, Hagiwara A. Light-dependent transcriptional events during resting egg hatching of the rotifer Brachionus manjavacas. Mar Genomics. 2015;20:25-31 pubmed publisher
    ..The data presented in this study indicate that DDRT-PCR-aided gene screening can be helpful to isolate candidate genes involved in the hatching process. ..
  20. Rossi M, Ghosh A, Kulikowicz T, Croteau D, Bohr V. Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst). 2010;9:796-804 pubmed publisher
    Humans have five members of the well conserved RecQ helicase family: RecQ1, Bloom syndrome protein (BLM), Werner syndrome protein (WRN), RecQ4, and RecQ5, which are all known for their roles in maintaining genome stability...
  21. Rossi M, Ghosh A, Bohr V. Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst). 2010;9:331-44 pubmed publisher
    ..The conserved RecQ family also includes RecQ1, Bloom syndrome protein (BLM), RecQ4, and RecQ5 in humans, as well as Sgs1 in Saccharomyces cerevisiae, Rqh1 in ..
  22. Tervasmäki A, Mantere T, Hartikainen J, Kauppila S, Lee H, Koivuluoma S, et al. Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer. Int J Cancer. 2018;142:2286-2292 pubmed publisher
    ..As a result, two missense variants in genes involved in DNA replication, RECQL p.I156M and POLG p...
  23. Croteau D, Singh D, Hoh Ferrarelli L, Lu H, Bohr V. RECQL4 in genomic instability and aging. Trends Genet. 2012;28:624-31 pubmed publisher
    ..Humans have five members of this family: WRN, BLM, RECQL4, RECQL1, and RECQL5...
  24. Rahman F, Tarique M, Ahmad M, Tuteja R. Plasmodium falciparum Werner homologue is a nuclear protein and its biochemical activities reside in the N-terminal region. Protoplasma. 2016;253:45-60 pubmed publisher
    ..all the helicase motifs along with all the functional domains and the predicted structure resembles with the human RecQ1 protein, whereas the C-terminal fragment (PfWrnC) contains no significant domain...
  25. Dong Y, Huang Y, Lu T. Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population. Genet Mol Res. 2015;14:1899-902 pubmed publisher
    In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population...
  26. Sami F, Lu X, Parvathaneni S, Roy R, Gary R, Sharma S. RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin. Biochem J. 2015;468:227-44 pubmed publisher
    ..Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ..
  27. Rump A, Benet Pages A, Schubert S, Kuhlmann J, Janavicius R, Machackova E, et al. Identification and Functional Testing of ERCC2 Mutations in a Multi-national Cohort of Patients with Familial Breast- and Ovarian Cancer. PLoS Genet. 2016;12:e1006248 pubmed publisher
    ..However, unlike the recently published RECQL example, none of our recurrent ERCC2 mutations showed convincing co-segregation with BC/OC or significant ..
  28. Fu W, Ligabue A, Rogers K, Akey J, Monnat R. Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases. Hum Mutat. 2017;38:193-203 pubmed publisher
    ..data, together with computational prediction, identified over 300 potentially pathogenic population variants in RECQL and RECQL5, the two RECQ helicases that are not yet linked to a heritable deficiency syndrome...
  29. Kim H, Yun J. Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage. Acta Biochim Biophys Sin (Shanghai). 2017;49:496-502 pubmed publisher
    ..of important regulators of cell cycle control and DNA repair, including p21, Gadd45, Rad50, DnaJ, and RecQL, was impaired upon Med1 knockdown...
  30. Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015;208:545-62 pubmed publisher
    ..EXO1, MRE11, and CtIP are not involved in the same mechanism of reversed fork processing, whereas human RECQ1 limits DNA2 activity by preventing extensive nascent strand degradation...
  31. Mazina O, Mazin A. Reconstituting the 4-Strand DNA Strand Exchange. Methods Enzymol. 2018;600:285-305 pubmed publisher
    ..g., rad54, blm, or recq1.
  32. Budhathoki J, Maleki P, Roy W, Janscak P, Yodh J, Balci H. A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase. Biophys J. 2016;110:2585-2596 pubmed publisher
    RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (BLM), Werner (WRN), RECQ4, and RECQ5. Both WRN and BLM have been shown to resolve G-quadruplex (GQ) structures...
  33. Wu J, Zhi L, Dai X, Cai Q, Ma W. Decreased RECQL5 correlated with disease progression of osteosarcoma. Biochem Biophys Res Commun. 2015;467:617-22 pubmed publisher
    Human RecQ helicase family, consisting of RECQL, RECQL4, RECQL5, BLM and WRN, has critical roles in genetic stability and tumorigenesis...
  34. Nguyen Dumont T, Myszka A, Karpinski P, Sasiadek M, Akopyan H, Hammet F, et al. FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine. BMC Med Genet. 2018;19:12 pubmed publisher
    FANCM and RECQL have recently been reported as breast cancer susceptibility genes and it has been suggested that they should be included on gene panel tests for breast cancer predisposition...
  35. Shamanna R, Lu H, Croteau D, Arora A, Agarwal D, Ball G, et al. Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer. Oncotarget. 2016;7:13269-84 pubmed publisher
    ..The five human RecQ helicases, RECQL1, Bloom, WRN, RECQL4 and RECQL5 play critical roles in DNA repair and cell survival after treatment with the ..
  36. Lu X, Parvathaneni S, Li X, Lal A, Sharma S. Transcriptome guided identification of novel functions of RECQ1 helicase. Methods. 2016;108:111-7 pubmed publisher
    ..Here we describe detailed experimental strategy for identification of RECQ1-regulated transcriptome that led us to uncover a novel association of RECQ1 in regulation of cancer cell migration ..
  37. Margalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton S. Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe. Cell. 2018;172:439-453.e14 pubmed publisher
    ..inhibits telomere replication, which can be mimicked by preventing replication fork restart through depletion of RECQ1 or PARG...
  38. Mojumdar A, De March M, Marino F, Onesti S. The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity. J Biol Chem. 2017;292:4176-4184 pubmed publisher
    RecQ helicases are essential in the maintenance of genome stability. Five paralogues (RecQ1, Bloom, Werner, RecQ4, and RecQ5) are found in human cells, with distinct but overlapping roles...
  39. de Voer R, Hahn M, Mensenkamp A, Hoischen A, Gilissen C, Henkes A, et al. Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer. Sci Rep. 2015;5:14060 pubmed publisher
    ..disorder characterized by chromosomal instability and increased cancer risk, caused by biallelic mutations in the RECQL-helicase gene BLM...
  40. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  41. Li D, Moughan J, Crane C, Hoffman J, Regine W, Abrams R, et al. RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704. Int J Radiat Oncol Biol Phys. 2016;94:554-60 pubmed publisher
    To confirm whether a previously observed association between RECQ1 A159C variant and clinical outcome of resectable pancreatic cancer patients treated with preoperative chemoradiation is reproducible in another patient population ..
  42. Li X, Lu X, Parvathaneni S, Bilke S, ZHANG H, Thangavel S, et al. Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion. Cell Cycle. 2014;13:2431-45 pubmed publisher
    ..linked with cancer susceptibility syndromes, but the association of the most abundant human RecQ homolog, RECQ1, with cellular transformation is yet unclear...
  43. Banerjee T, Brosh R. RECQL: a new breast cancer susceptibility gene. Cell Cycle. 2015;14:3540-3 pubmed publisher
    ..2 groups have led to the discovery in distinct populations of multiple breast cancer susceptibility mutations in RECQL, a gene that encodes a DNA helicase involved in homologous recombination repair and response to replication stress...
  44. Li L, Gao M, Song B, Zhang H, Wang Y. Effects of RECQ1 helicase silencing on non-small cell lung cancer cells. Biomed Pharmacother. 2016;83:1227-1232 pubmed publisher
    b>RECQ1, the most abundant one of the human RecQ helicases family, has been identified as a prometastasis gene in breast and cervical cancers...
  45. Sami F, Gary R, Fang Y, Sharma S. Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain. Mutat Res. 2016;790:8-18 pubmed publisher
    ..The RECQ1 gene encodes the most abundant RecQ homolog in humans...
  46. Parvathaneni S, Stortchevoi A, Sommers J, Brosh R, Sharma S. Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS ONE. 2013;8:e62481 pubmed publisher
    ..Human RecQ homologs include RECQ1, BLM, WRN, RECQ4, and RECQ5?, three of which have been linked to diseases with elevated risk of cancer and growth ..
  47. Cybulski C, Carrot Zhang J, Kluźniak W, Rivera B, Kashyap A, Wokołorczyk D, et al. Germline RECQL mutations are associated with breast cancer susceptibility. Nat Genet. 2015;47:643-6 pubmed publisher
    ..We identified rare recurrent RECQL mutations in each population...
  48. Vittori M, Breznik B, Hrovat K, Kenig S, Lah T. RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos. Genes (Basel). 2017;8: pubmed publisher
    b>RECQ1 helicase has multiple roles in DNA replication, including restoration of the replication fork and DNA repair, and plays an important role in tumour progression...
  49. Kume T, Jiang H, Topczewska J, Hogan B. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001;15:2470-82 pubmed
    ..We propose that the two genes interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. ..
  50. Woodrick J, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, et al. A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J. 2017;36:1605-1622 pubmed publisher
    ..This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1-XPF endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase and RPA The novel ..
  51. Arora A, Parvathaneni S, Aleskandarany M, Agarwal D, Ali R, Abdel Fatah T, et al. Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. Mol Cancer Ther. 2017;16:239-250 pubmed publisher
    b>RECQL1, a key member of the RecQ family of DNA helicases, is required for DNA replication and DNA repair. Two recent studies have shown that germline RECQL1 mutations are associated with increased breast cancer susceptibility...
  52. Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Oncotarget. 2017;8:75924-75942 pubmed publisher
    ..Here, we report that RECQ1, a breast cancer susceptibility gene that encodes the most abundant RecQ helicase in humans, is a p53-regulated ..
  53. Wang P, Rennekamp A, Yuan Y, Lieberman P. Topoisomerase I and RecQL1 function in Epstein-Barr virus lytic reactivation. J Virol. 2009;83:8090-8 pubmed publisher
    ..We also found that the RecQL1 helicase, which is known to associate with Kaposi's sarcoma-associated herpesvirus (KSHV) OriLyt, interacts with ..
  54. Akbari M, Cybulski C. RECQL: a DNA helicase in breast cancer. Oncotarget. 2015;6:26558-9 pubmed publisher
  55. Sanada S, Futami K, Terada A, Yonemoto K, Ogasawara S, Akiba J, et al. RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer. PLoS ONE. 2013;8:e72820 pubmed publisher
    This study analyzed the clinicopathological correlation between ovarian cancer (OC) and RECQL1 DNA helicase to assess its therapeutic potential...
  56. Banerjee T, Sommers J, Huang J, Seidman M, Brosh R. Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress. Curr Biol. 2015;25:2830-2838 pubmed publisher
    ..b>RECQ1, the first human RecQ helicase discovered [2-4] and the most abundant [5], was recently implicated in breast ..
  57. Pike A, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, et al. Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures. Proc Natl Acad Sci U S A. 2015;112:4286-91 pubmed publisher
    ..Here, we solved crystal structures of the human RECQ1 helicase in complexes with tailed-duplex DNA and ssDNA...
  58. Garige M, Sharma S. Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure. Int J Toxicol. 2014;33:373-81 pubmed publisher
    The 5 known RecQ helicases in humans (RECQ1, BLM, WRN, RECQL4, and RECQ5) have demonstrated roles in diverse genome maintenance mechanisms but their functions in safeguarding the genome from environmental toxicants are poorly understood...
  59. Contreras Levicoy J, Moreira Ramos S, Rojas D, Urbina F, Maldonado E. Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery. Gene. 2012;505:318-23 pubmed publisher
    ..through different ion exchange columns and affinity chromatography, we purified two proteins: DDB1 and RECQL (DNA damage-binding protein 1 and ATP-dependent DNA helicase Q1 respectively)...
  60. Bogdanova N, Pfeifer K, Schürmann P, Antonenkova N, Siggelkow W, Christiansen H, et al. Analysis of a RECQL splicing mutation, c.1667_1667+3delAGTA, in breast cancer patients and controls from Central Europe. Fam Cancer. 2017;16:181-186 pubmed publisher
    b>RECQL is a DNA helicase required for genomic stability. Two studies have recently identified RECQL as a novel breast cancer susceptibility gene. The most common RECQL mutation, the 4 bp-deletion c...
  61. Mo D, Zhao Y, Balajee A. Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. Cancer Lett. 2018;413:1-10 pubmed publisher
    ..Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes characterized by accelerated aging symptoms ..
  62. Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau D, et al. Human RECQL1 participates in telomere maintenance. Nucleic Acids Res. 2014;42:5671-88 pubmed publisher
    ..Here, we report a novel role for RECQL1, the most abundant human RecQ helicase but functionally least studied, in telomere maintenance...
  63. Seki T, Tada S, Katada T, Enomoto T. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochem Biophys Res Commun. 1997;234:48-53 pubmed
    We isolated two cDNA clones encoding human proteins which interact with DNA helicase Q1/RecQL, a human homologue of Eschelichia coli RecQ protein, by two-hybrid screening...
  64. Zhang A, Xi X. Molecular cloning of a splicing variant of human RECQL helicase. Biochem Biophys Res Commun. 2002;298:789-92 pubmed
    ..This cDNA variant was produced by the deletion of 176 bases at the 5(') end of human RecQL gene, presumably by an alternative mRNA splicing...
  65. Li D, Suzuki H, Liu B, Morris J, Liu J, Okazaki T, et al. DNA repair gene polymorphisms and risk of pancreatic cancer. Clin Cancer Res. 2009;15:740-6 pubmed publisher
    ..We analyzed 9 single nucleotide polymorphisms of 7 DNA repair genes (LIG3, LIG4, OGG1, ATM, POLB, RAD54L, and RECQL) in 734 patients with pancreatic adenocarcinoma and 780 healthy controls using the Taqman method...
  66. Sommers J, Banerjee T, Hinds T, Wan B, Wold M, Lei M, et al. Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner. J Biol Chem. 2014;289:19928-41 pubmed publisher
    ..The stimulation of helicase-catalyzed protein displacement is also observed with the DNA helicase RECQ1, suggesting a conserved functional interaction of RPA-interacting helicases...
  67. Shinozuka K, Tang H, Jones R, Li D, Nieto Y. Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies. Biol Blood Marrow Transplant. 2016;22:843-9 pubmed publisher
    ..21 germline SNPs of the gemcitabine metabolism genes CDA, deoxycytidine kinase, and hCNT3; DNA damage repair genes RECQL, X-ray repair complementing 1, RAD54L, ATM, ATR, MLH1, MSH2, MSH3, TREX1, EXO1, and TP73; and multidrug-resistance ..
  68. Matsushita Y, Yokoyama Y, Yoshida H, Osawa Y, Mizunuma M, Shigeto T, et al. The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer. J Ovarian Res. 2014;7:107 pubmed publisher
    ..Although previous studies have reported that the level of RECQL1 expression is correlated with the prognosis of some of malignancies, the function of RECQL1 is not yet clarified...
  69. Cui S, Klima R, Ochem A, Arosio D, Falaschi A, Vindigni A. Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A. J Biol Chem. 2003;278:1424-32 pubmed
    ..In this work, we describe the enzymatic characterization of RECQ1. The helicase has 3' to 5' polarity, cannot start the unwinding from a blunt-ended terminus, and needs a 3'-single-..
  70. Viziteu E, Klein B, Basbous J, Lin Y, Hirtz C, Gourzones C, et al. RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma. Leukemia. 2017;31:2104-2113 pubmed publisher
    ..genome-wide screen for genes responding to DNA methyltransferases (DNMT) inhibition in MM cells, we identified RECQ1 among the most downregulated genes...
  71. Xie J, Bessling S, Cooper T, Dietz H, McCallion A, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007;176:1339-42 pubmed
    ..We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination. ..
  72. Kwong A, Shin V, Cheuk I, Chen J, Au C, Ho D, et al. Germline RECQL mutations in high risk Chinese breast cancer patients. Breast Cancer Res Treat. 2016;157:211-215 pubmed publisher
    Recently, RECQL was reported as a new breast cancer susceptibility gene...
  73. Choi J, Xu M, Makowski M, Zhang T, Law M, Kovacs M, et al. A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. Nat Genet. 2017;49:1326-1335 pubmed publisher
    ..947 with rs3219090), as displaying allele-specific transcriptional activity. A proteomic screen identified RECQL as binding to rs144361550 in an allele-preferential manner...
  74. Sun J, Wang Y, Xia Y, Xu Y, Ouyang T, Li J, et al. Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer. PLoS Genet. 2015;11:e1005228 pubmed publisher
    ..cancer at or before the age of 35) we found that two index cases carried a potentially deleterious mutation in the RECQL gene (RecQ helicase-like; chr12p12)...
  75. Xu X, Liu Y. Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. EMBO J. 2009;28:568-77 pubmed publisher
    ..Taken together, our data provide the first biochemical clues underlying the molecular function of RECQ4 in DNA replication and genome maintenance. ..
  76. Tao J, Tao S, Han J, Zhou Z, Zhang X, Wang H, et al. RECQL1 plays an important role in the development of tongue squamous cell carcinoma. Cell Physiol Biochem. 2014;33:1579-90 pubmed publisher
    b>RECQL1, a member of the human RECQ helicase family, participates in DNA repair. Recent reports showed that RECQL1 silencing in cancer cells resulted in mitotic catastrophe, which prevented tumor growth in murine models...