RECK

Summary

Gene Symbol: RECK
Description: reversion inducing cysteine rich protein with kazal motifs
Alias: ST15, reversion-inducing cysteine-rich protein with Kazal motifs, membrane-anchored glycoprotein (metastasis and invasion), suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs), suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs), suppressor of tumorigenicity 15 protein
Species: human
Products:     RECK

Top Publications

  1. Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, et al. RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin. J Biol Chem. 2009;284:3461-9 pubmed publisher
    The membrane-anchored protease regulator RECK plays important roles in mammalian development and tumor suppression. The biochemical bases of these bioactivities, however, remain poorly understood...
  2. Takeuchi T, Hisanaga M, Nagao M, Ikeda N, Fujii H, Koyama F, et al. The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clin Cancer Res. 2004;10:5572-9 pubmed
    b>RECK, a membrane-anchored regulator of matrix metalloproteinases (MMPs), is widely expressed in healthy tissue, whereas it is expressed at lower levels in many tumor-derived cell lines...
  3. Nagini S. RECKing MMP: relevance of reversion-inducing cysteine-rich protein with kazal motifs as a prognostic marker and therapeutic target for cancer (a review). Anticancer Agents Med Chem. 2012;12:718-25 pubmed
    Reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is a membrane-anchored glycoprotein that negatively regulates the activities of matrix metalloproteinases (MMPs) and inhibits tumor invasion, metastasis, and angiogenesis...
  4. Eisenberg I, Hochner H, Sadeh M, Argov Z, Mitrani Rosenbaum S. Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene. Cytogenet Genome Res. 2002;97:58-61 pubmed
    The human RECK gene, mapped at 9p13-->p12, is known as a tumor suppressor gene and as a key regulator of extracellular matrix integrity and angiogenesis...
  5. Takemoto N, Tada M, Hida Y, Asano T, Cheng S, Kuramae T, et al. Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung. Lung Cancer. 2007;58:376-83 pubmed
    ..an endogenous matrix metalloproteinase (MMP) inhibitor, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), is able to inhibit tumour angiogenesis, invasion, and metastasis through inhibition of MMP-2, MMP-9, and membrane ..
  6. Miki T, Takegami Y, Okawa K, Muraguchi T, Noda M, Takahashi C. The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. J Biol Chem. 2007;282:12341-52 pubmed
    The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is anchored to the cell surface via glycosylphosphatidylinositol...
  7. Qi M, Li J, Li Y. [Clinicopathological significance of expressions of RECK and MMP-2 in esophageal squamous carcinoma]. Zhonghua Zhong Liu Za Zhi. 2010;32:283-5 pubmed
    To investigate the role and clinicopathological significance of RECK and MMP-2 expressions in esophageal squamous cell carcinoma (ESCC)...
  8. Rabien A, Ergün B, Erbersdobler A, Jung K, Stephan C. RECK overexpression decreases invasive potential in prostate cancer cells. Prostate. 2012;72:948-54 pubmed publisher
    b>RECK is a tumor suppressor which inhibits metastasis and angiogenesis. Based on RECK expression in prostate cancer tissue and cell lines, our aim was to investigate functional relevance of RECK for prostate carcinoma...
  9. Lei H, Hemminki K, Altieri A, Johansson R, Enquist K, Hallmans G, et al. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. Breast Cancer Res Treat. 2007;103:61-9 pubmed
    ..In this, so far largest case-control study, we genotyped eight SNPs in the MMP1, MMP2, MMP3, MMP9, MMP13, RECK and TIMP3 genes in a well-characterized breast cancer series of 959 cases and 952 controls from Sweden...

More Information

Publications84

  1. Chang H, Cho C, Hung W. Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. Cancer Sci. 2007;98:169-73 pubmed
    ..the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lung cancer ..
  2. Loayza Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H, Noda M. Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs. Oncogene. 2010;29:2638-48 pubmed publisher
    ..The membrane-anchored protease regulator RECK is downregulated in many cancers, and forced expression of RECK in tumor cells results in decreased malignancy in ..
  3. Li Y, Zhang Y, Zheng Q. Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci. 2005;25:552-4 pubmed
    In order to study the expression of transformation suppressor gene RECK and MMP-9 in hilar cholangiocarcinomas and its clinical significance, and explore the roles of RECK gene in metastasis and invasion of hilar cholangiocarcinoma, the ..
  4. Hsu M, Chang H, Hung W. HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. J Biol Chem. 2006;281:4718-25 pubmed
    ..In this study, we demonstrate that the HER-2/neu oncogene inhibits the expression of the MMP inhibitor RECK to promote cell invasion...
  5. Masui T, Doi R, Koshiba T, Fujimoto K, Tsuji S, Nakajima S, et al. RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. Clin Cancer Res. 2003;9:1779-84 pubmed
    The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene was initially isolated as a transformation suppressor gene. The RECK gene is expressed widely in normal organs but is undetectable in many tumor-derived cell lines...
  6. Li N, Tang B, Zhu E, Li B, Zhuang Y, Yu S, et al. Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK. FEBS Lett. 2012;586:722-8 pubmed publisher
    ..Mechanistically, we identified RECK as a novel target of miR-222, and also confirmed their relationship by the inverse correlation of mRNA expression ..
  7. Wittschieber D, Stenzinger A, Klauschen F, Stephan C, Jung K, Erbersdobler A, et al. Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness. Pathobiology. 2011;78:123-31 pubmed publisher
    ..The MMP repressor RECK and the MMP activator EMMPRIN regulate the invasive potential by metalloproteinase-induced stromal degradation...
  8. Chung T, Pan M, Kuo C, Wong R, Lin C, Chen M, et al. Impact of RECK gene polymorphisms and environmental factors on oral cancer susceptibility and clinicopathologic characteristics in Taiwan. Carcinogenesis. 2011;32:1063-8 pubmed publisher
    ..The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) has a significant effect on tumorigenesis by limiting angiogenesis and invasion of tumors through the ..
  9. Gabriely G, Wurdinger T, Kesari S, Esau C, Burchard J, Linsley P, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28:5369-80 pubmed publisher
    ..miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs)...
  10. Hirata H, Ueno K, Shahryari V, Tanaka Y, Tabatabai Z, Hinoda Y, et al. Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer. PLoS ONE. 2012;7:e51056 pubmed publisher
    ..However cell apoptosis was inhibited by miR-182-5p. We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms...
  11. Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara R, et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001;107:789-800 pubmed
    ..We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis...
  12. Stenzinger A, von Winterfeld M, Rabien A, Warth A, Kamphues C, Dietel M, et al. Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer. Hum Pathol. 2012;43:1314-21 pubmed publisher
    ..An important inhibitor of matrix metalloproteinases is reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein...
  13. Jung H, Phillips B, Patel R, Cohen D, Jakymiw A, Kong W, et al. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 2012;287:29261-72 pubmed publisher
    ..the regulation of the tumor suppressor gene reversion-inducing cysteine-rich protein with kazal motifs (RECK) by two keratinization-associated miRNAs, miR-7 and miR-21...
  14. Kang H, Kim H, Kim K, Oh J, Lee M, Seol S, et al. RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. J Orthop Res. 2007;25:696-702 pubmed
    ..A novel MMPs inhibitor, reversion inducing cysteine rich protein with Kazal motifs (RECK), is known to down-regulate MMPs and suppress the invasive and metastatic ..
  15. Cho C, Wang J, Chang H, Chang C, Hung W. Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. J Cell Physiol. 2007;213:65-9 pubmed
    Down-regulation of RECK, an important metastasis suppressor gene, has been found in human colon cancer. However, the molecular mechanism for this down- regulation and its biological significance are still unclear...
  16. Chang H, Cho C, Hung W. Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. Cancer Res. 2006;66:8413-20 pubmed
    b>RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase activity to suppress tumor invasion and metastasis...
  17. Namwat N, Puetkasichonpasutha J, Loilome W, Yongvanit P, Techasen A, Puapairoj A, et al. Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. J Gastroenterol. 2011;46:664-75 pubmed publisher
    Reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) has been implicated in the attenuation of tumor metastasis by negatively regulating metalloproteinase (MMP) levels...
  18. Takahashi C, Sheng Z, Horan T, Kitayama H, Maki M, Hitomi K, et al. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A. 1998;95:13221-6 pubmed
    ..One such gene, RECK, encodes a membrane-anchored glycoprotein of about 110 kDa with multiple epidermal growth factor-like repeats and ..
  19. Liu L, Chang H, Chiang L, Hung W. Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. Cancer Res. 2003;63:3069-72 pubmed
    ..b>RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor ..
  20. Simizu S, Takagi S, Tamura Y, Osada H. RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. Cancer Res. 2005;65:7455-61 pubmed
    b>RECK, a glycosylphosphatidylinositol (GPI)-anchored glycoprotein, negatively regulates matrix metalloproteinases (MMP), such as MMP-9, and inhibits tumor invasion and metastasis...
  21. Xu J, Wu S, Shi X. Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma. J Orthop Res. 2010;28:1621-5 pubmed publisher
    Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a novel membrane-anchored matrix metalloproteinase inhibitor, have been shown to be associated with prognosis and suppress tumor progression through angiogenesis ..
  22. Yoshida Y, Ninomiya K, Hamada H, Noda M. Involvement of the SKP2-p27(KIP1) pathway in suppression of cancer cell proliferation by RECK. Oncogene. 2012;31:4128-38 pubmed publisher
    The membrane-anchored matrix metalloproteinase-regulator RECK is often downregulated in cancers; in some cases, a significant correlation between the level of residual RECK in resected tumors and patient survival has been noted...
  23. Mori T, Moriuchi R, Okazaki E, Yamada K, Katamine S. Tgat oncoprotein functions as a inhibitor of RECK by association of the unique C-terminal region. Biochem Biophys Res Commun. 2007;355:937-43 pubmed
    We identified RECK, a membrane-anchored glycoprotein negatively regulating the activities of MMPs, as a molecule interacting with Tgat oncoprotein consisting of RhoGEF domain and the unique C-terminal 15 amino acids...
  24. Takagi S, Simizu S, Osada H. RECK negatively regulates matrix metalloproteinase-9 transcription. Cancer Res. 2009;69:1502-8 pubmed publisher
    b>RECK, a glycosylphosphatidylinositol-anchored glycoprotein, inhibits the enzymatic activities of some matrix metalloproteinases (MMP), thereby suppressing tumor cell metastasis; however, the detailed mechanism is still obscure...
  25. Zhang L, Xie Q, Shan S, Tabor M, Junkins Hopkins J. Reduced Expression of RECK Protein May Help Differentiate Cutaneous Malignant Melanoma from Melanocytic Nevus. Anticancer Res. 2015;35:3185-91 pubmed
    ..Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is an endogenous inhibitor of many proteins that promote tumor invasion and progression...
  26. Zhang H, Cong J, Cui M, Feng Y, Chen C. [Expression and significance of RECK, metalloproteinase-9 and vascular endothelial growth factor-C in colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2010;13:695-8 pubmed
    To investigate the expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor-C (VEGF-C) in colorectal cancer...
  27. Chiang C, Hou M, Hung W. Up-regulation of miR-182 by ?-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK. Biochim Biophys Acta. 2013;1830:3067-76 pubmed publisher
    ..The correlation between miR-182 and RECK was analyzed by Western blotting, real-time RT-PCR and 3(')-untranslated region reporter assay...
  28. Chen X, Shi C, Wang C, Liu W, Chu Y, Xiang Z, et al. The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Sci Rep. 2017;7:40958 pubmed publisher
    ..by luciferase assays and Western blot analysis, reversion-inducing cysteine-rich protein with kazal motifs (Reck) was identified to be one of the target genes of miR-497-5p, and Reck could suppress the expression of matrix ..
  29. Zhang J, Kong X, Li J, Luo Q, Li X, Shen L, et al. miR-96 promotes tumor proliferation and invasion by targeting RECK in breast cancer. Oncol Rep. 2014;31:1357-63 pubmed publisher
    ..Luciferase assays revealed that miR-96 directly bound to the 3'-untranslated region (3'-UTR) of RECK. qRT-PCR and western blot analysis confirmed that miR-96 regulated the expression of RECK both at the mRNA and ..
  30. Markovska R, Stoeva T, Boyanova L, Stankova P, Pencheva D, Keuleyan E, et al. Dissemination of successful international clone ST15 and clonal complex 17 among Bulgarian CTX-M-15 producing K. pneumoniae isolates. Diagn Microbiol Infect Dis. 2017;89:310-313 pubmed publisher
    ..The CTX-M-15 producers belonged to ST15 (34.1%) and to a lesser extent to CC17 (ST16, ST17, ST336)...
  31. Sekizuka T, Nai E, Yoshida T, Endo S, Hamajima E, Akiyama S, et al. Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. BMC Infect Dis. 2017;17:774 pubmed publisher
    ..Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain...
  32. Rabien A, Jung M, Fritzsche F, Loening S, Kristiansen G, Jung K. [Tumor suppressor RECK in prostate carcinoma. Decreased RECK expression as indicator of proteolytic imbalance]. Urologe A. 2007;46:1081-2 pubmed
  33. Cheong Y, Kim Y, Kang H, Choi S, Lee H. Rapid label-free identification of Klebsiella pneumoniae antibiotic resistant strains by the drop-coating deposition surface-enhanced Raman scattering method. Spectrochim Acta A Mol Biomol Spectrosc. 2017;183:53-59 pubmed publisher
    ..We also applied the method to identify three strains from colony samples, ATCC70063 (control), ST11 and ST15; these are the prevalent quinolone-resistant K. pneumoniae strains in East Asia...
  34. Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, et al. MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. J Clin Invest. 2009;119:492-503 pubmed publisher
    ..and lower expression of the MT1-MMP inhibitor, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), on isolated circulating human CD34+ progenitor cells compared with immature BM cells...
  35. Gutiérrez J, Droppelmann C, Salsoso R, Westermeier F, Toledo F, Salomon C, et al. A Hypothesis for the Role of RECK in Angiogenesis. Curr Vasc Pharmacol. 2016;14:106-15 pubmed
    ..Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a membrane-anchored inhibitor of different matrix metalloproteinases and a-disintegrin and metalloproteinases, ..
  36. Goudarzi M, Bahramian M, Satarzadeh Tabrizi M, Udo E, Figueiredo A, Fazeli M, et al. Genetic diversity of methicillin resistant Staphylococcus aureus strains isolated from burn patients in Iran: ST239-SCCmec III/t037 emerges as the major clone. Microb Pathog. 2017;105:1-7 pubmed publisher
    ..7%). ST239-SCCmec III/t037 (34%) was the most common genotype followed by ST239-SCCmec III/t030 (24.5%), ST15-SCCmec IV/t084 (15.1%), ST22-SCCmec IV/t790 (13.2%), and ST239-SCCmec III/t631 (13.2%)...
  37. Chiang C, Chu P, Hou M, Hung W. MiR-182 promotes proliferation and invasion and elevates the HIF-1?-VEGF-A axis in breast cancer cells by targeting FBXW7. Am J Cancer Res. 2016;6:1785-98 pubmed
    ..tumor tissues and its up-regulation increased tumorigenicity and invasiveness by repressing a tumor suppressor RECK. In this study, we showed that overexpression miR-182 regulated actin distribution and filopodia formation to ..
  38. Pan Y, Liang H, Chen W, Zhang H, Wang N, Wang F, et al. microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. RNA Biol. 2015;12:276-89 pubmed publisher
    ..colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs (RECK). Firstly, bioinformatics analysis predicted RECK as a conserved target of miR-200b/c...
  39. Rimoldi S, Pagani C, Longhi E, Cristo V, Gregorio A, Mancon A, et al. Remitting infections due to community-acquired Panton-Valentine leukocidin-producing Staphylococcus aureus in the Milan area. J Infect Public Health. 2018;11:255-259 pubmed publisher
    ..clone of community-acquired (CA)-MRSA, PVL positive ST8, and SCCmec IV in families A and B and CA-MSSA PVL positive ST15 in family C. S...
  40. Cardoso J, Cayô R, Girardello R, Gales A. Diversity of mechanisms conferring resistance to β-lactams among OXA-23-producing Acinetobacter baumannii clones. Diagn Microbiol Infect Dis. 2016;85:90-7 pubmed publisher
    ..It was also verified that ompW was down-regulated in all isolates belonging to the ST15 (CC15). On the other hand, carO and omp33-36 genes were overexpressed in 48.4% and 58...
  41. Chen Z, Pan W, Xian W, Cheng H, Zheng J, Hu Q, et al. Identification of Infantile Diarrhea Caused by Breast Milk-Transmitted Staphylococcus aureus Infection. Curr Microbiol. 2016;73:498-502 pubmed publisher
    ..Four Sequence types (STs) were found among all the isolates; they are ST15, ST188, and ST59, respectively...
  42. Kumari R, Silic M, Jones Hall Y, Nin Velez A, Yang J, Mittal S, et al. Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget. 2018;9:23494-23504 pubmed publisher
    ..Previously, we identified RECK as a tumor suppressor gene candidate on chromosome 9p using zebrafish-human comparative oncogenomics...
  43. Barbosa J, Reis S, Nunes M, Ferreira Y, Leite K, Nahas W, et al. The Obstructed Bladder: Expression of Collagen, Matrix Metalloproteinases, Muscarinic Receptors, and Angiogenic and Neurotrophic Factors in Patients With Benign Prostatic Hyperplasia. Urology. 2017;106:167-172 pubmed publisher
    ..of metalloproteinases (TIMPs) TIMP-1, TIMP-2, and reversion-inducing cysteine-rich protein with kazal motifs (RECK); CHRM2 and CHRM3; VEGF and CD105; and NGF and nerve growth factor receptor (NGFr)...
  44. Chmielarczyk A, Pobiega M, Romaniszyn D, Wójkowska Mach J. Multi-locus sequence typing (MLST) of non-fermentative Gram-negative bacilli isolated from bloodstream infections in southern Poland. Folia Microbiol (Praha). 2018;63:191-196 pubmed publisher
    ..Four S. maltophilia isolates matched STs present in the database (ST4, ST15, ST116, ST142), seven isolates showing novel sequence types. Among P. aeruginosa and S...
  45. Xia H, Chen S, Chen K, Huang H, Ma H. MiR-96 promotes proliferation and chemo- or radioresistance by down-regulating RECK in esophageal cancer. Biomed Pharmacother. 2014;68:951-8 pubmed publisher
    ..MiR-96 up-regulation was demonstrated in 145 EC samples and RECK down-regulation was validated in EC cell lines...
  46. Qin J, Luo M. MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK. FEBS Lett. 2014;588:99-104 pubmed publisher
    ..We identify RECK as a direct target of miR-221, reveal its expression to be inversely correlated with miR-221 in CRC samples and ..
  47. Sato T, Harada K, Usui M, Tsuyuki Y, Shiraishi T, Tamura Y, et al. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages. Microb Drug Resist. 2017;: pubmed publisher
    ..were reported to be found in strains isolated from human; isolates considered high-risk clones in human (ST11, ST15, and ST147) were also identified. In conclusion, the isolation of tigecycline-nonsusceptible K...
  48. Rabien A, Stephan C, Kilic E, Weichert W, Kristiansen G, Miller K, et al. Renal cell neoplasias: reversion-inducing cysteine-rich protein with Kazal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis. J Transl Med. 2013;11:258 pubmed publisher
    ..Knowing the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) as an inhibitor of matrix metalloproteinases and the extracellular matrix metalloproteinase inducer (EMMPRIN) ..
  49. Chang C, Hung W, Chang H. The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo. J Cell Mol Med. 2008;12:2781-9 pubmed publisher
    b>RECK is a membrane-anchored glycoprotein which may negatively regulate matrix metalloproteinase (MMP) activity to suppress tumor invasion and metastasis...
  50. Chen X, Jiang F, Shi N, Zhou H, Zhang L, Chen Y, et al. RECK gene polymorphisms influence NSCLC susceptibility, but not the chemotherapy response status in Chinese cohort. Cell Biochem Biophys. 2014;69:567-71 pubmed publisher
    To test the possible association between reversion-inducing cysteine-rich protein with Kazal motifs (RECK) genetic variants and susceptibility as well as the chemotherapy response status to in patients with advanced non-small cell lung ..
  51. Mahl C, Egea V, Megens R, Pitsch T, Santovito D, Weber C, et al. RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells. Cell Mol Life Sci. 2016;73:1489-501 pubmed publisher
    The membrane-anchored glycoprotein RECK (reversion-inducing cysteine-rich protein with Kazal motifs) inhibits expression and activity of certain matrix metalloproteinases (MMPs), thereby suppressing tumor cell metastasis...
  52. Li Y, Xu D, Bao C, Zhang Y, Chen D, Zhao F, et al. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget. 2015;6:2421-33 pubmed
    ..The reversion-inducing-cysteine-rich protein with kazal motifs (RECK) and ecotropic viral integration site 5 (EVI5) were identified as the direct and functional targets of miR-135b in ..
  53. Guan Y, Guo L, Zukerberg L, Rueda B, Styer A. MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma. Reprod Biol Endocrinol. 2016;14:45 pubmed publisher
    ..Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression...
  54. Zhou D, Deng Y, Li R, Yin P, Ye C. Concurrent alterations of RAGE, RECK, and MMP9 protein expression are relevant to Epstein-Barr virus infection, metastasis, and survival in nasopharyngeal carcinoma. Int J Clin Exp Pathol. 2014;7:3245-54 pubmed
    ..of receptor for advanced glycation end products (RAGE), reversion inducing cysteine-rich protein with Kazal motifs (RECK) and matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and their correlations with ..
  55. Wang L, Wang Q, Li H, Han L. Expression of MiR200a, miR93, metastasis-related gene RECK and MMP2/MMP9 in human cervical carcinoma--relationship with prognosis. Asian Pac J Cancer Prev. 2013;14:2113-8 pubmed
    ..The present study was conducted to assess expression of miR93, miR200a, RECK, MMP2, MMP9 in invasive cervical carcinoma, and analyze their clinical significance...
  56. Turton J, Payne Z, Coward A, Hopkins K, Turton J, Doumith M, et al. Virulence genes in isolates of Klebsiella pneumoniae from the UK during 2016, including among carbapenemase gene-positive hypervirulent K1-ST23 and 'non-hypervirulent' types ST147, ST15 and ST383. J Med Microbiol. 2017;: pubmed publisher
    ..Hypervirulent types carry an array of virulence genes including rmpA/rmpA2, coding for capsule up-regulation. We sought to identify isolates carrying these elements among submissions to the UK national reference laboratory during 2016...
  57. Xie J, Tan Z, Tang X, Mo M, Liu Y, Gan R, et al. MiR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis. World J Gastroenterol. 2014;20:17439-47 pubmed publisher
    ..predicted that the 3' untranslated region (UTR) of reversion-inducing cysteine-rich protein with Kazal motif (RECK) contains three miR-374b-5p target sequences...
  58. Liu N, Cao Y, Zhu G. Expression of matrix metalloproteinases-2, -9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease. Arch Oral Biol. 2017;75:62-67 pubmed publisher
    ..b>RECK (reversion-inducing-cysteine-rich protein with kazal motifs), a novel membrane-anchored inhibitor of MMPs, could ..
  59. Discacciati M, Gimenes F, Pennacchi P, Faião Flores F, Zeferino L, Derchain S, et al. MMP-9/RECK Imbalance: A Mechanism Associated with High-Grade Cervical Lesions and Genital Infection by Human Papillomavirus and Chlamydia trachomatis. Cancer Epidemiol Biomarkers Prev. 2015;24:1539-47 pubmed publisher
    ..In the present study, we analyzed the state of the MMP-9-RECK axis in cervical carcinogenesis...
  60. Rahmah N, Sakai K, Li Y, Sano K, Hongo K. Comparison of manual and digital microvascular density counting of RECK expression in glioma. Neuropathology. 2012;32:245-51 pubmed publisher
    A microvascular density (MVD) counting method for reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression, using a digital image analysis tool, has advantages over manual counting by microscope...
  61. Bai T, Dong D, Pei L. Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncol Rep. 2014;31:2293-7 pubmed publisher
    ..Finally, we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK, followed by activation of the JNK signaling pathway and ER stress...
  62. Liu N, Zhou B, Zhu G. Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases. Med Sci Monit. 2016;22:1936-8 pubmed
    ..However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-inducing cysteine-rich protein with Kazal motifs), a novel membrane-anchored inhibitor of MMPs, could ..
  63. Lin H, Chiang C, Hung W. STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. Br J Cancer. 2013;109:731-8 pubmed publisher
    ..Enforced expression of STAT3 decreases the endogenous MMP inhibitor RECK protein but not mRNA level in H460 cells...
  64. Obasi A, Nwachukwu S, Ugoji E, Kohler C, Göhler A, Balau V, et al. Extended-Spectrum ?-Lactamase-Producing Klebsiella pneumoniae from Pharmaceutical Wastewaters in South-Western Nigeria. Microb Drug Resist. 2017;23:1013-1018 pubmed publisher
    ..PFGE and MLST analysis revealed five clones belonging to four sequence types (ST11, ST15, ST37, ST101), and clone K...
  65. Dong Q, Yu D, Yang C, Jiang B, Zhang H. Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis. Int J Exp Pathol. 2010;91:368-73 pubmed publisher
    ..the most common malignant tumour in infancy; the reversion-inducing cysteine-rich protein with Kazal motifs gene (RECK) is a tumour suppressor gene...
  66. Jaidane N, Bonnin R, Mansour W, Girlich D, Creton E, Cotellon G, et al. Genomic Insights into Colistin-Resistant Klebsiella pneumoniae from a Tunisian Teaching Hospital. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..pneumoniae These isolates belonged to the 5 different sequence types (ST11, ST15, ST101, ST147, and ST392), and their resistome was composed of acquired β-lactamases, including extended-spectrum ..
  67. Son D, Jung Y, Seo Y, Park H, Lee D, Kim S, et al. Interleukin-32α Inhibits Endothelial Inflammation, Vascular Smooth Muscle Cell Activation, and Atherosclerosis by Upregulating Timp3 and Reck through suppressing microRNA-205 Biogenesis. Theranostics. 2017;7:2186-2203 pubmed publisher
    ..Collectively, our studies demonstrated that IL-32α upregulates the atheroprotective genes Timp3 and Reck by downregulating microRNA-205 through regulation of the Rprd2-Dgcr8/Ddx5-Dicer1 biogenesis pathway...
  68. Yeh H, Tseng Y, Hsu Y, Lan S, Wu S, Raghavaraju G, et al. Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity. BMC Cancer. 2015;15:172 pubmed publisher
    ..Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a metastasis inhibitor gene, suppresses matrix metalloproteinase (MMP) activity in the metastatic cascade...
  69. Liu J, Chi D, Lu H, Zhang T, Yamakawa T. Reversion-inducing-cysteine-rich protein with Kazal motif is involved in intimal hyperplasia in carotid arteries: a new insight in the prevention of restenosis after vascular angioplasty. Ann Vasc Surg. 2015;29:1293-9 pubmed publisher
    ..Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a membrane-anchored glycoprotein that negatively regulates the activity of MMPs, such as MMP-9 and MMP-2, which ..
  70. Deng Y, Zhou D, Zeng L. [Expression and significance of MTA1 and RECK gene in nasopharyngeal carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;25:534-8 pubmed
    To determine the expression of MTA1 and RECK gene in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathological features...
  71. Shukla C, Edwards D, Sethia K. Re: Anja Rabien, Mick Burkhardt, Monika Jung, Florian Fritzsche, Martin Ringsdorf, Hanka Schicktanz, Stefan A. Loening, Glen Kristiansen and Klaus Jung. Decreased RECK expression indicating proteolytic imbalance in prostate cancer is associated with . Eur Urol. 2007;52:1533-4; author reply 1534-5 pubmed
  72. Zhang C, Ling Y, Zhang C, Xu Y, Gao L, Li R, et al. The silencing of RECK gene is associated with promoter hypermethylation and poor survival in hepatocellular carcinoma. Int J Biol Sci. 2012;8:451-8 pubmed publisher
    To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC). We analyzed RECK methylation by MSP, and RECK mRNA by real-time PCR in 74 HCC...
  73. Abd Elfatah G, Gad Allah A. RASSF1A, RECK genotypes and haplotypes in Egyptian population with Hepatocellular carcinoma. Immunol Lett. 2016;173:36-41 pubmed publisher
    ..This study aimed to investigate the role of tumor suppressor genes RASSF1A Ala133Ser and RECK rs11788747polymorphisms and their haplotypes in HCC...
  74. Walsh L, Roy D, Reyngold M, Giri D, Snyder A, Turcan S, et al. RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch. Oncogene. 2015;34:2189-203 pubmed publisher
    ..Here we show that the membrane protein RECK (Reversion-inducing cysteine-rich protein with kazal motifs) controls breast cancer metastasis by modulating a ..
  75. Jeon H, Lee K, Lee S, Kim W, Lee Y. Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways. Arch Pharm Res. 2011;34:137-45 pubmed publisher
    Downregulation of the tumor suppressor, reversion-inducing cysteine-rich protein with Kazal motifs (RECK) has been reported under hypoxic conditions (Lee et al...