Gene Symbol: RDH10
Description: retinol dehydrogenase 10
Alias: SDR16C4, retinol dehydrogenase 10, retinol dehydrogenase 10 (all-trans), short chain dehydrogenase/reductase family 16C member 4
Species: human
Products:     RDH10

Top Publications

  1. Kalitin N, Chernykh Y, Buravtsova I. [Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RARα and PPARβ/δ genes and some clinical characteristics in multiple myeloma. Vopr Onkol. 2016;62:626-631 pubmed
    The significance of quantitative changes of ALDH1A1 and RDH10 gene expression in 22 non-treated multiple myeloma patients were studied. We found a direct correlation between the expression of ALDH1A1 and RDH10 genes...
  2. Serio R, Laursen K, Urvalek A, Gross S, Gudas L. Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ. J Biol Chem. 2019;294:5536-5548 pubmed publisher
    ..As shown with CRISPR/Cas9 knockout lines, the retinol dehydrogenase gene Rdh10 and a functional RARE in the ROL transporter stimulated by retinoic acid 6 (Stra6) gene are required ..
  3. Smith J, Walker H, Thompson H, Collinson J, Vargesson N, Erskine L. Lens-regulated retinoic acid signalling controls expansion of the developing eye. Development. 2018;145: pubmed publisher
    ..We identified RDH10, a gene crucial for retinoic acid synthesis during embryogenesis, as a key factor downregulated in the ..
  4. Zhang M, Liu C, Hu M, Zhang J, Xu P, Li F, et al. High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats. J Pharmacol Sci. 2015;127:430-8 pubmed publisher
    ..HFD rats exhibited significantly downregulated hepatic ADHs/RDHs activity and Adh1, Rdh10 and Dhrs9 expression. Oppositely, hepatic RALDHs activity and Raldh1 expression were upregulated in HFD rats...
  5. Lee S, Jiang H, Trent C, Yuen J, Narayanasamy S, Curley R, et al. Cardiac dysfunction in β-carotene-15,15'-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism. Am J Physiol Heart Circ Physiol. 2014;307:H1675-84 pubmed publisher
    ..changes were accompanied by elevations in levels of genes important to retinoid metabolism, specifically retinol dehydrogenase 10 and retinol-binding protein 4, as well as genes involved in lipid metabolism, including peroxisome ..
  6. Al Hussaini H, Kilarkaje N. Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats. Eur J Pharmacol. 2018;834:142-151 pubmed publisher
    ..Diabetes inhibited the expression of retinoic acid metabolism pathway genes- Lpl, Lrat, RPE65, Rdh5, Rdh10, Rdh12, Rlbp1 and Rbp1 and increased Crabp1...
  7. Siegenthaler J, Ashique A, Zarbalis K, Patterson K, Hecht J, KANE M, et al. Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009;139:597-609 pubmed publisher
    ..In addition, Rdh10- and Raldh2-expressing cells in the dorsal meninges were either reduced or absent in the Foxc1 mutants, and Rdh10 ..
  8. Mason M, Hockman D, Curry L, Cunningham T, Duester G, Logan M, et al. Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb. Evodevo. 2015;6:6 pubmed publisher
    ..is not activated by retinoic acid (RA) signalling as it is present in the retained interdigital tissue of Rdh10 (trex/trex) mice, which lack RA...
  9. Belyaeva O, Chang C, Berlett M, Kedishvili N. Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family. Chem Biol Interact. 2015;234:135-43 pubmed publisher
    ..chordate species are found in three clades of SDR16C family containing retinoid active enzymes, which are retinol dehydrogenase 10 (RDH10), retinol dehydrogenases E2 (RDHE2) and RDHE2-similar, and dehydrogenase reductase (SDR family) ..

More Information


  1. Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
    ..signaling activity at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme...
  2. D Aniello E, Ravisankar P, Waxman J. Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS ONE. 2015;10:e0138588 pubmed publisher
    ..Recent studies have demonstrated that RDH10 is a critical core component of the machinery that produces RA in mouse and Xenopus embryos...
  3. Yang D, Vuckovic M, Smullin C, Kim M, Lo C, Devericks E, et al. Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism. Diabetes. 2018;67:662-673 pubmed publisher
    ..This study examined postnatal contributions of Rdh10 to atRA biosynthesis and physiological functions of endogenous atRA...
  4. Bonney S, Siegenthaler J. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. Eneuro. 2017;4: pubmed publisher
    ..junctional protein expression was unaffected in mouse mutants that have a reduced capacity to synthesize RA (Rdh10 mutants). Furthermore, embryos exposed to a RA-enriched diet did not enhance BBB protein expression...
  5. Martí Solans J, Belyaeva O, Torres Aguila N, Kedishvili N, Albalat R, Canestro C. Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate. Mol Biol Evol. 2016;33:2401-16 pubmed publisher
    ..This work illustrates how the identification of patterns of gene coelimination-in our case five losses (Rdh10, Rdh16, Bco1, Aldh1a, and Cyp26)-is a useful strategy to recognize gene network modules associated to distinct ..
  6. Cunningham T, Brade T, Sandell L, Lewandoski M, Trainor P, Colas A, et al. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS ONE. 2015;10:e0137894 pubmed publisher
    ..The Raldh2-/- small somite defect was rescued by treatment with an FGF receptor antagonist. Rdh10 mutants, with a less severe RA synthesis defect, were found to exhibit a small somite defect and anterior ..
  7. Bonney S, Harrison Uy S, Mishra S, MacPherson A, Choe Y, Li D, et al. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016;36:7786-801 pubmed publisher
    ..Our analysis of globally RA-deficient embryos (Rdh10 mutants) points to an important, non-cell-autonomous function for RA in the development of the vasculature in the ..
  8. Sahu B, Sun W, Perusek L, Parmar V, Le Y, Griswold M, et al. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015;290:27239-47 pubmed publisher
    ..Here we describe a third retinol dehydrogenase in the RPE, RDH10, which can produce 11-cis-retinal...
  9. Chen F, Jiang Z, Jiang S, Li L, Lin X, Gou Z, et al. Dietary vitamin A supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders. Poult Sci. 2016;95:30-40 pubmed publisher
    ..05). The relative expression of retinol dehydrogenase 10 (RDH10) transcripts in the walls of white follicles increased with 5,400 IU/kg VA supplementation (P < ..
  10. Lenti E, Farinello D, Yokoyama K, Penkov D, Castagnaro L, Lavorgna G, et al. Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development. J Clin Invest. 2016;126:2452-64 pubmed publisher
    ..growth was impaired in mice lacking either cytochrome P450 26B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA deficiency...
  11. Nakajima T, Iguchi T, Sato T. Retinoic acid signaling determines the fate of uterine stroma in the mouse Müllerian duct. Proc Natl Acad Sci U S A. 2016;113:14354-14359 pubmed
    ..b>Retinol dehydrogenase 10 (RDH10) and aldehyde dehydrogenase family 1 subfamily A2 (ALDH1A2) mRNAs and proteins and transactivation ..
  12. Xue Y, Sato S, Razafsky D, Sahu B, Shen S, Potter C, et al. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017;7:2390 pubmed publisher
    ..Here, we sought to determine whether retinol dehydrogenase 10 (RDH10), upregulated in rod/cone hybrid retinas and expressed abundantly in Müller cells, is the enzyme ..
  13. Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L, et al. Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017;23:60-89 pubmed
    ..RPE-expressed genes, including RPE65, RDH5, and RDH10, as well as miR-204/211, were greatly increased in the ARPE-19 cells maintained at confluence for 4 months...
  14. Kole C, Berdugo N, Da Silva C, Aït Ali N, Millet Puel G, Pagan D, et al. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. PLoS ONE. 2016;11:e0150758 pubmed publisher
    ..We find that OTX2S is able to bind to the chromatin at the promoter of the retinal dehydrogenase 10 (RDH10) gene.
  15. Metzler M, Sandell L. Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos. Nutrients. 2016;8: pubmed
    ..reversible first step in conversion of the precursor vitamin A to the active retinoid RA is mediated by retinol dehydrogenase 10 (RDH10) and dehydrogenase/reductase (SDR family) member 3 (DHRS3), two related membrane-bound proteins ..
  16. Szatmari I, Pap A, Rühl R, Ma J, Illarionov P, Besra G, et al. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006;203:2351-62 pubmed
    ..on retinoic acid synthesis by inducing the expression of retinol and retinal metabolizing enzymes such as retinol dehydrogenase 10 and retinaldehyde dehydrogenase type 2 (RALDH2)...
  17. Nash D, Arrington C, Kennedy B, Yandell M, Wu W, Zhang W, et al. Shared Segment Analysis and Next-Generation Sequencing Implicates the Retinoic Acid Signaling Pathway in Total Anomalous Pulmonary Venous Return (TAPVR). PLoS ONE. 2015;10:e0131514 pubmed publisher
    ..also uncovered deleterious variants in genes associated with retinoic acid signaling, including NODAL and retinol dehydrogenase 10. These data indicate that genetic variation in the retinoic acid signaling pathway confers, in part, ..
  18. Wright D, Buenger D, Abashev T, Lindeman R, Ding J, Sandell L. Retinoic acid regulates embryonic development of mammalian submandibular salivary glands. Dev Biol. 2015;407:57-67 pubmed publisher
    ..By examining late stage RA deficient embryos of Rdh10 mutant mice we show that SMG development requires RA in a dose-dependent manner...
  19. Farjo K, Moiseyev G, Takahashi Y, Crouch R, Ma J. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009;50:5089-97 pubmed publisher
    ..This study was conducted to characterize the 11-cis-RDH activity of RDH10 in vitro and specifically to determine whether RDH10 can functionally and physically interact with visual cycle ..
  20. Takahashi Y, Moiseyev G, Farjo K, Ma J. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009;419:113-22, 1 p following 122 pubmed publisher
    RDH10 (retinol dehydrogenase 10) was originally identified from the retinal pigment epithelium and retinal Müller cells. It has retinoid oxidoreductase activity and is thought to play a role in the retinoid visual cycle...
  21. Lee S, Belyaeva O, Wu L, Kedishvili N. Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture. J Biol Chem. 2011;286:13550-60 pubmed publisher
    ..The results of this study demonstrate that ectopic expression of retinol dehydrogenase 10 (RDH10, SDR16C4) in skin rafts dramatically increases proliferation and inhibits differentiation of ..
  22. Rossi E, Picozzi P, Bodega B, Lavazza C, Carlo Stella C, Marozzi A, et al. Forced expression of RDH10 gene retards growth of HepG2 cells. Cancer Biol Ther. 2007;6:238-44 pubmed
    The constitutive over-expression of the retinol dehydrogenase 10 (RDH10) gene, involved in retinoic acid (RA) biosynthesis, produced in HepG2 cells a significant antiproliferative response, but not signs of apoptosis...
  23. Gyöngyösi A, Szatmari I, Pap A, Dezso B, Pos Z, Szeles L, et al. RDH10, RALDH2, and CRABP2 are required components of PPAR?-directed ATRA synthesis and signaling in human dendritic cells. J Lipid Res. 2013;54:2458-74 pubmed publisher
    ..Here we present that only a subset of murine and human DCs express the necessary enzymes, including RDH10, RALDH2, and transporter cellular retinoic acid binding protein (CRABP)2, to produce ATRA and efficient signaling...
  24. Adams M, Lee S, Belyaeva O, Wu L, Kedishvili N. Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10. Chem Biol Interact. 2017;276:88-94 pubmed publisher
    ..It is well established that retinol dehydrogenase 10 (RDH10, SDR16C4), which belongs to the 16C family of the short chain dehydrogenase/reductase (SDR) ..
  25. Kurosaka H, Wang Q, SANDELL L, Yamashiro T, Trainor P. Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet. 2017;26:1268-1279 pubmed publisher
    ..In this study, we discovered that mice with mutations in retinol dehydrogenase 10 (Rdh10), which perturbs Vitamin A metabolism and retinoid signaling, exhibit fully penetrant CA...
  26. Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, et al. Identification of genes associated with non-small-cell lung cancer promotion and progression. Lung Cancer. 2010;67:151-9 pubmed publisher
    ..were submitted to homology search in GenBank database which revealed the following genes: TSPAN14, CDH12, RDH10, CYP4Z1, KIR, E2F4, PHACTR3, PHF20, PRAME family member and SLC2A13...
  27. Belyaeva O, Johnson M, Kedishvili N. Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. J Biol Chem. 2008;283:20299-308 pubmed publisher
    Human retinol dehydrogenase 10 (RDH10) was implicated in the oxidation of all-trans-retinol for biosynthesis of all-trans-retinoic acid, however, initial assays suggested that RDH10 prefers NADP(+) as a cofactor, undermining its role as ..
  28. Picozzi P, Marozzi A, Fornasari D, Benfante R, Barisani D, Meneveri R, et al. Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene. FEBS Lett. 2003;554:59-66 pubmed
    A cDNA clone up-regulated in hydraulic lung edema in rabbit showed high similarity with human RDH10 mRNA, which encodes a protein involved in retinoic acid metabolism...
  29. Belyaeva O, Adams M, Wu L, Kedishvili N. The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis. J Biol Chem. 2017;292:5884-5897 pubmed publisher
    ..We show that ROC is composed of at least two subunits of NAD+-dependent retinol dehydrogenase 10 (RDH10), which catalyzes the oxidation of retinol to retinaldehyde, and two subunits of NADPH-dependent ..
  30. Haushalter C, Asselin L, Fraulob V, Dolle P, Rhinn M. Retinoic acid controls early neurogenesis in the developing mouse cerebral cortex. Dev Biol. 2017;430:129-141 pubmed publisher
    ..We analysed corticogenesis in Rdh10 null mutants, in which an RA deficiency is generated as the intracellular retinol to retinaldehyde conversion is ..
  31. Shannon S, Moise A, Trainor P. New insights and changing paradigms in the regulation of vitamin A metabolism in development. Wiley Interdiscip Rev Dev Biol. 2017;6: pubmed publisher
    ..recently been established as a critical nodal point in the synthesis of retinoic acid, and over the past decade, RDH10 and DHRS3 have emerged as the predominant enzymes that regulate this reversible reaction...
  32. Wu B, Chen Y, Chen Y, Fan J, Rohrer B, Crouch R, et al. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest Ophthalmol Vis Sci. 2002;43:3365-72 pubmed
    ..The full-length cDNA encoding a novel atRDH, RDH10, was cloned by PCR based on an expressed sequence tag (EST)...
  33. Adams M, Belyaeva O, Wu L, Kedishvili N. The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014;289:14868-80 pubmed publisher
    ..This study demonstrates that DHRS3 requires the presence of retinol dehydrogenase 10 (RDH10) to display its full catalytic activity...
  34. Obrochta K, Krois C, Campos B, Napoli J. Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1. J Biol Chem. 2015;290:7259-68 pubmed publisher
    ..Six h after re-feeding, Rdh1 expression decreased 80-90% in liver and brown adipose tissue and Rdh10 expression was decreased 45-63% in liver, pancreas, and kidney, all relative to mice fasted 16 h...