RDC1

Summary

Gene Symbol: RDC1
Description: atypical chemokine receptor 3
Alias: CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1, atypical chemokine receptor 3, C-X-C chemokine receptor type 7, G protein-coupled receptor, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, chemokine (C-X-C motif) receptor 7, chemokine orphan receptor 1
Species: human
Products:     RDC1

Top Publications

  1. Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta K, et al. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 2008;283:4283-94 pubmed
    Several reports have recently documented that CXCR7/RDC1 functions as a chemokine receptor for SDF-1/CXCL12, which regulates a spectrum of normal and pathological processes...
  2. Hattermann K, Mentlein R. An infernal trio: the chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology. Ann Anat. 2013;195:103-10 pubmed publisher
    ..focus on the signaling and effects of the widespread chemokine CXCL12 and its long known G protein-coupled receptor CXCR4 and the recently discovered non-G protein-coupled receptor CXCR7 with a detailed reflection on glioma biology.
  3. Libert F, Passage E, Parmentier M, Simons M, Vassart G, Mattei M. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Genomics. 1991;11:225-7 pubmed
    ..G-protein-coupled receptor family were obtained by selective amplification and cloning from thyroid cDNA and termed RDC1, RDC4, RDC7, and RDC8. RDC7 and RDC8 have recently been identified as A1 and A2 adenosine receptors, respectively...
  4. Torossian F, Anginot A, Chabanon A, Clay D, Guerton B, Desterke C, et al. CXCR7 participates in CXCL12-induced CD34+ cell cycling through ?-arrestin-dependent Akt activation. Blood. 2014;123:191-202 pubmed publisher
    ..to be responsible for CXCL12-induced biological effects until the recent discovery of its second receptor, CXCR7. Until now, the participation of CXCR7 in CXCL12-induced HSPC cycling and survival is unknown...
  5. Luker K, Gupta M, Steele J, Foerster B, Luker G. Imaging ligand-dependent activation of CXCR7. Neoplasia. 2009;11:1022-35 pubmed
    ..Functions of CXCL12 previously were believed to be controlled only by receptor CXCR4, but CXCR7 was recently identified as a second receptor for this chemokine...
  6. Infantino S, Moepps B, Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol. 2006;176:2197-207 pubmed
    Based on phylogenetic analysis and chromosomal mapping, the orphan receptor RDC1 was proposed to be a chemokine receptor...
  7. Hernandez L, Magalhaes M, Coniglio S, Condeelis J, Segall J. Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res. 2011;13:R128 pubmed publisher
    ..However, CXCR7 also binds to CXCL12 and has been recently found to enhance lung and breast primary tumor growth, as well as ..
  8. Ray P, Mihalko L, Coggins N, Moudgil P, Ehrlich A, Luker K, et al. Carboxy-terminus of CXCR7 regulates receptor localization and function. Int J Biochem Cell Biol. 2012;44:669-78 pubmed publisher
    Chemokine receptor CXCR7 is essential for normal development, and this receptor promotes initiation and progression of diseases including cancer and autoimmunity...
  9. Tripathi V, Verma R, Dinda A, Malhotra N, Kaur J, Luthra K. Differential expression of RDC1/CXCR7 in the human placenta. J Clin Immunol. 2009;29:379-86 pubmed publisher
    ..CXCR7, now a deorphanized G protein coupled receptor that has been recently shown to bind to the ligands ITAC and CXCL12 has been proposed to act as a co-..

More Information

Publications66

  1. Burns J, Summers B, Wang Y, Melikian A, Berahovich R, Miao Z, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. 2006;203:2201-13 pubmed
    ..This paper characterizes an alternate receptor, CXCR7, which binds with high affinity to SDF-1 and to a second chemokine, interferon-inducible T cell alpha ..
  2. Hattermann K, Held Feindt J, Lucius R, Müerköster S, Penfold M, Schall T, et al. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res. 2010;70:3299-308 pubmed publisher
    ..Recently, CXCR7 was identified as a novel, alternate receptor for CXCL12 and CXCL11/I-TAC...
  3. Hoffmann F, Müller W, Schütz D, Penfold M, Wong Y, Schulz S, et al. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012;287:28362-77 pubmed publisher
    ..The second CXCL12-receptor CXCR7 modulates the CXCL12/CXCR4 pathway by acting as a CXCL12 scavenger and exerts G protein-independent functions...
  4. Totonchy J, Osborn J, Botto S, Clepper L, Moses A. Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. PLoS ONE. 2013;8:e69828 pubmed publisher
    ..The alternative SDF-1/CXCL12 receptor, CXCR7, is frequently and specifically expressed in tumor-associated vessels...
  5. Goldmann T, Drömann D, Radtke J, Marwitz S, Lang D, Schultz H, et al. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy. Virchows Arch. 2008;452:347-8 pubmed publisher
  6. Odemis V, Lipfert J, Kraft R, Hajek P, Abraham G, Hattermann K, et al. The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. Glia. 2012;60:372-81 pubmed publisher
    SDF-1/CXCL12 binds to the chemokine receptors, CXCR4 and CXCR7, and controls cell proliferation and migration during development, tumorigenesis, and inflammatory processes...
  7. Nagata S, Ishihara T, Robberecht P, Libert F, Parmentier M, Christophe J, et al. RDC1 may not be VIP receptor. Trends Pharmacol Sci. 1992;13:102-3 pubmed
  8. Singh R, Lokeshwar B. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Cancer Res. 2011;71:3268-77 pubmed publisher
    The proinflammatory chemokine receptor CXCR7 that binds the ligands CXCL11 and CXCL12 (SDF-1a) is elevated in a variety of human cancers, but its functions are not understood as it does not elicit classical chemokine receptor signaling...
  9. Watanabe K, Penfold M, Matsuda A, Ohyanagi N, Kaneko K, Miyabe Y, et al. Pathogenic role of CXCR7 in rheumatoid arthritis. Arthritis Rheum. 2010;62:3211-20 pubmed publisher
    ..b>CXCR7 was recently identified as an alternative receptor for CXCL12...
  10. Heinrich E, Lee W, Lu J, Lowy A, Kim J. Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. J Transl Med. 2012;10:68 pubmed publisher
    ..to be a select ligand for chemokine receptor CXCR4, chemokine CXCL12 is now known to activate both CXCR4 and CXCR7. However, very little is known about the co-expression of these receptors in cancer cells...
  11. Schrevel M, Karim R, Ter Haar N, van der Burg S, Trimbos J, Fleuren G, et al. CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients. Br J Cancer. 2012;106:1520-5 pubmed publisher
    ..The aim of the present study was to determine protein expression of CXCR7, its putative co-receptors epidermal growth factor receptor (EGFR) and CXCR4, its predominant ligand CXCL12, their ..
  12. Boudot A, Kerdivel G, Habauzit D, Eeckhoute J, Le Dily F, Flouriot G, et al. Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells. PLoS ONE. 2011;6:e20898 pubmed publisher
    CXCR4 and CXCR7 are the two receptors for the chemokine CXCL12, a key mediator of the growth effect of estrogens (E2) in estrogen receptor (ER)-positive breast cancers...
  13. Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes H, et al. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS ONE. 2010;5:e9175 pubmed publisher
    b>CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses...
  14. Shimizu N, Soda Y, Kanbe K, Liu H, Mukai R, Kitamura T, et al. A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. J Virol. 2000;74:619-26 pubmed
    ..mRNA expression of an orphan GPCR, RDC1, was detected in the brain-derived cells, the C8166 T-cell line, and peripheral blood lymphocytes, all of which are ..
  15. Tarnowski M, Grymula K, Reca R, Jankowski K, Maksym R, Tarnowska J, et al. Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas. Mol Cancer Res. 2010;8:1-14 pubmed publisher
    Rhabdomyosarcomas (RMS) express CXCR4 and CXCR7 receptors that bind prometastatic alpha-chemokine stromal-derived factor-1 (SDF-1)...
  16. Yao X, Zhou L, Han S, Chen Y. High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancer. J Int Med Res. 2011;39:1253-64 pubmed
    ..This study investigated whether the expression of CXC chemokine receptor types 4 and 7 (CXCR4 and CXCR7, respectively), determined immunohistochemically, was associated with clinicopathological characteristics and ..
  17. Monnier J, Boissan M, L Helgoualc h A, Lacombe M, Turlin B, Zucman Rossi J, et al. CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells. Eur J Cancer. 2012;48:138-48 pubmed publisher
    ..Here we investigated the novel chemokine receptor CXCR7/RDC1 in HCC progression, its two known ligands CXCL12 and CXCL11, as well as the other CXCL12 receptor, CXCR4...
  18. Yan X, Cai S, Xiong X, Sun W, Dai X, Chen S, et al. Chemokine receptor CXCR7 mediates human endothelial progenitor cells survival, angiogenesis, but not proliferation. J Cell Biochem. 2012;113:1437-46 pubmed publisher
    ..It was considered to act via its unique receptor CXCR4 for a long time. CXCR7 is a second, recently identified receptor for SDF-1, and its role in human EPCs is unclear...
  19. Tarnowski M, Grymula K, Liu R, Tarnowska J, Drukala J, Ratajczak J, et al. Macrophage migration inhibitory factor is secreted by rhabdomyosarcoma cells, modulates tumor metastasis by binding to CXCR4 and CXCR7 receptors and inhibits recruitment of cancer-associated fibroblasts. Mol Cancer Res. 2010;8:1328-43 pubmed publisher
    ..with CXCR4, and as we report here for the first time, MIF may also engage another SDF-1-binding receptor (CXCR7) as well...
  20. Hao M, Zheng J, Hou K, Wang J, Chen X, Lu X, et al. Role of chemokine receptor CXCR7 in bladder cancer progression. Biochem Pharmacol. 2012;84:204-14 pubmed publisher
    ..Here, role of the CXCR7 receptor in bladder cancer was further explored...
  21. Rajagopal S, Kim J, Ahn S, Craig S, Lam C, Gerard N, et al. Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A. 2010;107:628-32 pubmed publisher
    ..Here we demonstrate that ligand binding to the decoy receptor CXCR7 does not result in activation of signaling pathways typical of G proteins but does activate MAP kinases through ..
  22. Gravel S, Malouf C, Boulais P, Berchiche Y, Oishi S, Fujii N, et al. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem. 2010;285:37939-43 pubmed publisher
    b>CXCR7 is an atypical chemokine receptor that signals through ?-arrestin in response to agonists without detectable activation of heterotrimeric G-proteins...
  23. Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, et al. CXCR7: a novel tumor endothelial marker in renal cell carcinoma. Pathol Int. 2012;62:309-17 pubmed publisher
    ..Expression of the chemokine receptor CXCR7 mRNA was higher in TECs than in NECs...
  24. Balabanian K, Lagane B, Infantino S, Chow K, Harriague J, Moepps B, et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem. 2005;280:35760-6 pubmed
    ..In CXCR4-negative cells expressing RDC1, CXCL12 promotes internalization of the receptor and chemotactic signals through RDC1. Collectively, our data indicate that RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12.
  25. Zabel B, Wang Y, Lewén S, Berahovich R, Penfold M, Zhang P, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009;183:3204-11 pubmed publisher
    b>CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act as a classical chemoattractant receptor...
  26. Luker K, Lewin S, Mihalko L, Schmidt B, Winkler J, Coggins N, et al. Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene. 2012;31:4750-8 pubmed publisher
    ..We used dual luciferase imaging to investigate CXCR7-dependent scavenging of CXCL12 in breast tumors in vivo and quantify effects of CXCR7 on tumor growth and ..
  27. Costello C, McCullagh B, Howell K, Sands M, Belperio J, Keane M, et al. A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease. Eur Respir J. 2012;39:1415-24 pubmed publisher
    ..cell dysfunction plays in the pathogenesis of pulmonary hypertensive diseases, we set out to establish if CXCR7, a receptor for the pro-angiogenic ligand CXCL12, is expressed in the vasculature of human lung diseases and ..
  28. Van Rechem C, Rood B, Touka M, Pinte S, Jenal M, Guerardel C, et al. Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). J Biol Chem. 2009;284:20927-35 pubmed publisher
    ..These studies identified several putative direct target genes, including CXCR7, a G-protein-coupled receptor recently identified as a scavenger receptor for the chemokine SDF-1/CXCL12...
  29. Xu H, Wu Q, Dang S, Jin M, Xu J, Cheng Y, et al. Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. PLoS ONE. 2011;6:e27399 pubmed publisher
    ..The present study shows that exposure to LPS elevated CXC chemokine receptor 7 (CXCR7) expression in colorectal carcinoma SW480 and Colo 205 cell lines expressing TLR4/myeloid differential protein (MD-..
  30. Hartmann T, Grabovsky V, Pasvolsky R, Shulman Z, Buss E, Spiegel A, et al. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J Leukoc Biol. 2008;84:1130-40 pubmed publisher
    ..b>CXCR7 is a second, recently identified receptor for CXCL12, but its role as an intrinsic G-protein-coupled receptor (..
  31. Miekus K, Jarocha D, Trzyna E, Majka M. Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation, activation of intracellular signaling pathways and migration of various tumor cell lines. Folia Histochem Cytobiol. 2010;48:104-11 pubmed publisher
    ..In this study we evaluated the expression and function of CXCR3 and CXCR7 receptors in cervical carcinoma, rhabdomyosarcoma and glioblastoma cell lines...
  32. Zheng K, Li H, Su X, Wang X, Tian T, Li F, et al. Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2010;29:31 pubmed publisher
    ..More recent studies have revealed that chemokine receptor CXCR7 plays an important role in cancer development...
  33. Kerdivel G, Boudot A, Pakdel F. Estrogen represses CXCR7 gene expression by inhibiting the recruitment of NF?B transcription factor at the CXCR7 promoter in breast cancer cells. Biochem Biophys Res Commun. 2013;431:729-33 pubmed publisher
    ..In this study, we explored the molecular mechanisms by which E2 regulates CXCR7 expression in breast cancer cells...
  34. Berahovich R, Zabel B, Lewén S, Walters M, Ebsworth K, Wang Y, et al. Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels. Immunology. 2014;141:111-22 pubmed publisher
    ..Here we show that both genetic deletion and pharmacological inhibition of CXCR7, a high-affinity CXCL12 receptor, caused pronounced increases in plasma CXCL12 levels...
  35. D Alterio C, Consales C, Polimeno M, Franco R, Cindolo L, Portella L, et al. Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer. Curr Cancer Drug Targets. 2010;10:772-81 pubmed
    ..The CXCR4 ligand, CXCL12, was shown to bind also the CXCR7 receptor, a recently deorphanized chemokine receptor whose signalling pathway and function are still controversial...
  36. Sreedharan S, Robichon A, Peterson K, Goetzl E. Cloning and expression of the human vasoactive intestinal peptide receptor. Proc Natl Acad Sci U S A. 1991;88:4986-90 pubmed
    ..The VIP receptor cloned exhibits less than or equal to 24% homology with other receptors in the same superfamily and thus represents a subset of G protein-coupled receptors for peptide ligands. ..
  37. Bennani Baiti I, Cooper A, Lawlor E, Kauer M, Ban J, Aryee D, et al. Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma. Clin Cancer Res. 2010;16:3769-78 pubmed publisher
    ..After filtering out the intercohort variability, CXCR4 and CXCR7 were found to be consistently associated with specific ES subsets...
  38. Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, et al. Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer. Cancer. 2009;115:2580-93 pubmed publisher
    ..CCR1-11, CXCR1-7, XCR1, and CX3CR1) in 11 cell lines of lung cancer, and gene expression of CXCR3, CXCR4, and CXCR7 (CXCR3/4/7) in surgical specimens of 127 patients who underwent complete resection for their NSCLC between May ..
  39. Duda D, Kozin S, Kirkpatrick N, Xu L, Fukumura D, Jain R. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?. Clin Cancer Res. 2011;17:2074-80 pubmed publisher
    ..g., AMD3100, NOX-A12, or CCX2066) as sensitizers to currently available therapies by targeting the CXCL12/CXCR4 and CXCL12/CXCR7 pathways.
  40. Canals M, Scholten D, de Munnik S, Han M, Smit M, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE. 2012;7:e34192 pubmed publisher
    The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively...
  41. Tarnowski M, Liu R, Wysoczynski M, Ratajczak J, Kucia M, Ratajczak M. CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells. Eur J Haematol. 2010;85:472-83 pubmed publisher
    b>CXCR7 was identified as another stromal-derived factor-1 (SDF-1)-binding receptor that also binds the interferon-inducible T-cell chemoattractant (I-TAC), and we became interested in its potential role in migration/adhesion of normal ..
  42. Berahovich R, Zabel B, Penfold M, Lewén S, Wang Y, Miao Z, et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010;185:5130-9 pubmed publisher
    Since the discovery that CXCR7 binds to CXCL12/SDF-1?, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny...
  43. Shimizu S, Brown M, Sengupta R, Penfold M, Meucci O. CXCR7 protein expression in human adult brain and differentiated neurons. PLoS ONE. 2011;6:e20680 pubmed publisher
    b>CXCR7 and CXCR4 are receptors for the chemokine CXCL12, which is involved in essential functions of the immune and nervous systems...
  44. Kumar R, Tripathi V, Ahmad M, Nath N, Mir R, Chauhan S, et al. CXCR7 mediated Gi? independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. Cell Immunol. 2012;272:230-41 pubmed publisher
    Chemokine receptors CXCR7 and CXCR4 bind to the same ligand stromal cell derived factor-1alpha (SDF-1?/CXCL12). We assessed the downstream signaling pathways mediated by CXCL12-CXCR7 interaction in Jurkat T cells...
  45. Décaillot F, Kazmi M, Lin Y, Ray Saha S, Sakmar T, Sachdev P. CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration. J Biol Chem. 2011;286:32188-97 pubmed publisher
    ..this study, we have attempted to identify the functional significance of the heteromeric complex between CXCR4 and CXCR7 chemokine receptors...
  46. Yates T, Knapp J, Gosalbez M, Lokeshwar S, Gomez C, Benitez A, et al. C-X-C chemokine receptor 7: a functionally associated molecular marker for bladder cancer. Cancer. 2013;119:61-71 pubmed publisher
    C-X-C chemokine receptor 4 (CXCR4) and CXCR7 are 7-transmembrane chemokine receptors of the stroma-derived factor (SDF-1). CXCR4, but not CXCR7, has been examined in bladder cancer (BCa)...
  47. Würth R, Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Porcile C, et al. Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature. J Neuroimmunol. 2011;234:115-23 pubmed publisher
    CXCR4 and CXCR7 chemokine receptors, and their ligands CXCL11 and CXCL12, have been often involved in tumor cell proliferation and survival. We report the expression pattern of these ligand/receptor pairs in 22 human meningiomas...
  48. Lee E, Han J, Kim K, Choi H, Cho E, Lee T. CXCR7 mediates SDF1-induced melanocyte migration. Pigment Cell Melanoma Res. 2013;26:58-66 pubmed publisher
    ..we demonstrate that a chemokine, stromal-derived factor-1 (SDF1, also known as CXCL12), and one of its receptor CXCR7 regulate normal human epidermal melanocyte (NHEM) migration...
  49. Miao Z, Luker K, Summers B, Berahovich R, Bhojani M, Rehemtulla A, et al. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci U S A. 2007;104:15735-40 pubmed
    ..Here, we demonstrate that CXCR7 (RDC1, CCX-CKR2), recently deorphanized as a chemokine receptor that binds chemokines CXCL11 and CXCL12, can ..
  50. Traynham C, Cannavo A, Zhou Y, Vouga A, Woodall B, Hullmann J, et al. Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circ Res. 2015;117:1001-12 pubmed publisher
    ..These data suggest that although nuclear-localized GRK5 is a pathological mediator after stress, this noncanonical nuclear activity of GRK5 is not induced during physiological hypertrophy. ..
  51. Dal Maso E, Just R, Hick C, Christopoulos A, Sexton P, Wootten D, et al. Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochem Pharmacol. 2018;148:111-129 pubmed publisher
    ..In addition, we report that the CTR exhibits constitutive internalization, independent of splice variant and polymorphism and this profile is unaltered by peptide binding. ..
  52. Alavi M, Hosseinzadeh H, Shamsizadeh A, Roohbakhsh A. The effect of O-1602, an atypical cannabinoid, on morphine-induced conditioned place preference and physical dependence. Pharmacol Rep. 2016;68:592-7 pubmed publisher
    Previous studies show that some non-CB1/non-CB2 effects of cannabinoids are mediated through G protein coupled receptor 55 (GPR55)...
  53. Elliott S, Parchim N, Kellems R, Xia Y, Soffici A, Daugherty P. A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50. Clin Immunol. 2016;168:64-71 pubmed publisher
    ..These results reveal the existence of molecular mimicry between EBNA-1 and placental GPR50, supporting a mechanism for IgG1 deposition in the pre-eclamptic placenta. ..
  54. Ribas R, Ghazoui Z, Gao Q, Pancholi S, Rani A, Dunbier A, et al. Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers. Breast Cancer Res. 2014;16:447 pubmed publisher
    ..In a panel of LTED cell lines, C-X-C chemokine receptor type 7 (CXCR7) and CXCR4 were upregulated compared to their wild types (wt), and CXCR7, but not CXCR4, was associated with ..
  55. Leśniak D, Jastrzębski S, Podlewska S, Czarnecki W, Bojarski A. Quo vadis G protein-coupled receptor ligands? A tool for analysis of the emergence of new groups of compounds over time. Bioorg Med Chem Lett. 2017;27:626-631 pubmed publisher
    ..gmum.net/vischem, which enables the investigation of chemical structures while referring to particular data points depicted in the figures and changes in compounds datasets over time. ..
  56. Shkurin A, Vellido A. Using random forests for assistance in the curation of G-protein coupled receptor databases. Biomed Eng Online. 2017;16:75 pubmed publisher
    ..The individual identification of consistently misclassified sequences should provide a tool for quality control to GPCR database curators. ..
  57. Wan J, Yin Y, Zhao M, Shen F, Chen M, Chen Q. The positivity of G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor is not different between type 1 and type 2 endometrial cancer. Oncotarget. 2017;8:90897-90904 pubmed publisher
    ..689). Our data further confirm that type 2 endometrial cancer may not be completely estrogen independent, and suggest that type 1 and type 2 endometrial cancer may have similar pathogenesis...