Gene Symbol: RCN2
Description: reticulocalbin 2
Alias: E6BP, ERC-55, ERC55, TCBP49, reticulocalbin-2, E6-binding protein, calcium-binding protein ERC-55, reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD)
Species: human
Products:     RCN2

Top Publications

  1. Nakakido M, Tamura K, Chung S, Ueda K, Fujii R, Kiyotani K, et al. Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. Int J Oncol. 2016;49:868-76 pubmed publisher
    ..Knockdown of PIGX as well as reticulocalbin 1 (RCN1) and reticulocalbin 2 (RCN2), which we found to interact with PIGX and was indicated to regulate calcium-dependent activities, ..
  2. von Deimling M, Häsler R, Steinbach V, Holterhus P, von Spiczak S, Stephani U, et al. Gene expression analysis in untreated absence epilepsy demonstrates an inconsistent pattern. Epilepsy Res. 2017;132:84-90 pubmed publisher
    ..Previously known genes including GABRA1, GABRB3, GABRG2, and RCN2 showed evidence for up- or down-regulation in individual experiments, but were not reliable across groups either...
  3. Alonso Rodríguez E, Fernández Piñar P, Sacristán Reviriego A, Molina M, Martín H. An Analog-sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway. J Biol Chem. 2016;291:5461-72 pubmed publisher
    ..Moreover, we identified the calcineurin regulator Rcn2, the 4E-BP (translation initiation factor eIF4E-binding protein) translation repressor protein Caf20, and the Golgi-..
  4. Davis Anderson K, Wesseling H, Siebert L, Lunde Young E, Naik V, Steen H, et al. Fetal regional brain protein signature in FASD rat model. Reprod Toxicol. 2018;76:84-92 pubmed publisher
    ..05) affected by alcohol. Thus, neurodevelopmental protein changes may directly relate to FASD neuropathology. ..
  5. Ludvigsen M, Jacobsen C, Maunsbach A, Honoré B. Identification and characterization of novel ERC-55 interacting proteins: evidence for the existence of several ERC-55 splicing variants; including the cytosolic ERC-55-C. Proteomics. 2009;9:5267-87 pubmed publisher
    ERC-55, encoded from RCN2, is localized in the ER and belongs to the CREC protein family...
  6. Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11:1161-78 pubmed publisher
  7. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  8. Kirkpatrick L, Matzuk M, Dodds D, Perin M. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem. 2000;275:17786-92 pubmed
    ..multimers (probably pentamers), and interact with taipoxin and taipoxin-associated calcium-binding protein 49 (TCBP49)...
  9. Wang J, Zhen D, Bianchi D, Androphy E, Chen J. Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization. Cytogenet Cell Genet. 1997;79:60-1 pubmed

More Information


  1. Dodds D, Omeis I, Cushman S, Helms J, Perin M. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. J Biol Chem. 1997;272:21488-94 pubmed
    ..neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-binding protein 49 (TCBP49)...
  2. Helbig I, Matigian N, Vadlamudi L, Lawrence K, Bayly M, Bain S, et al. Gene expression analysis in absence epilepsy using a monozygotic twin design. Epilepsia. 2008;49:1546-54 pubmed publisher
    ..Differential expression for EGR1 (an immediate early gene) and RCN2 (coding for the calcium-binding protein Reticulocalbin 2) were reconfirmed by qRT-PCR in the independent sample...
  3. Ding D, Jiang W, Yu W, Zhu H, Liu J, Saiyin H, et al. Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. Oncogene. 2017;36:6691-6700 pubmed publisher
    Hepatocellular carcinoma (HCC) is a major health threat worldwide. Although the involvement of reticulocalbin-2 (RCN2) in cell differentiation has been reported, its function in oncogenesis is poorly understood...
  4. Weis K, Griffiths G, Lamond A. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. J Biol Chem. 1994;269:19142-50 pubmed
  5. Matsuda S, Nagasawa H, Yamashiro N, Yasuno N, Watanabe T, Kitazawa H, et al. Rice RCN1/OsABCG5 mutation alters accumulation of essential and nonessential minerals and causes a high Na/K ratio, resulting in a salt-sensitive phenotype. Plant Sci. 2014;224:103-11 pubmed publisher
    ..in field-grown plants were evident in rcn1 compared to original line 'Shiokari' and four independent rcn mutants, rcn2, rcn4, rcn5 and rcn6...
  6. Chen J, Reid C, Band V, Androphy E. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science. 1995;269:529-31 pubmed
    ..One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6...
  7. Ding D, Jiang W, Yu W, Zhu H, Liu J, Saiyin H, et al. Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. Oncogene. 2017;36:6747-6748 pubmed publisher
    ..This corrects the article DOI: 10.1038/onc.2017.230...
  8. Wang G, Wang Q, Fan Y, He X. Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer. Am J Cancer Res. 2017;7:2169-2179 pubmed
    ..However, the expression pattern and potential function of Reticulocalbin 2 (RCN2) in colorectal cancer has not been addressed yet...