RBP4

Summary

Gene Symbol: RBP4
Description: retinol binding protein 4
Alias: MCOPCB10, RDCCAS, PRBP, RBP, plasma retinol-binding protein, retinol binding protein 4, plasma, retinol-binding protein 4, interstitial
Species: human

Top Publications

  1. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
  2. ncbi Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes
    Anita Ost
    Department of Cell Biology and Diabetes Research Centre, Linkoping University, SE58185 Linköping, Sweden
    FASEB J 21:3696-704. 2007
  3. doi Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women
    Ziad Mallat
    Institut National de la Santé et de la Recherche Médicale Unit 689, Hopital Lariboisiere, 75010 Paris, France
    J Clin Endocrinol Metab 94:255-60. 2009
  4. doi The metabolic role of retinol binding protein 4: an update
    G A Christou
    Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece
    Horm Metab Res 44:6-14. 2012
  5. doi Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 206:239-44. 2009
  6. ncbi Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
  7. doi Effects of retinol binding protein-4 on vascular endothelial cells
    Kohzo Takebayashi
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Biochem Biophys Res Commun 408:58-64. 2011
  8. ncbi Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
    M von Eynatten
    Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675, Munich, Germany
    Diabetologia 50:1930-7. 2007
  9. ncbi Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes
    Shai Gavi
    Department of Medicine, Division of General Medicine and Geriatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8154, USA
    J Clin Endocrinol Metab 92:1886-90. 2007
  10. pmc An RBP4 promoter polymorphism increases risk of type 2 diabetes
    M van Hoek
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:1423-8. 2008

Research Grants

Detail Information

Publications193 found, 100 shown here

  1. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
    ..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed...
  2. ncbi Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes
    Anita Ost
    Department of Cell Biology and Diabetes Research Centre, Linkoping University, SE58185 Linköping, Sweden
    FASEB J 21:3696-704. 2007
    ..Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-binding protein (RBP4), and RBP4 can induce insulin resistance in mice. However, little is known about how RBP4 affects insulin signaling...
  3. doi Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women
    Ziad Mallat
    Institut National de la Santé et de la Recherche Médicale Unit 689, Hopital Lariboisiere, 75010 Paris, France
    J Clin Endocrinol Metab 94:255-60. 2009
    Recent studies reported that retinol-binding protein 4 (RBP4) has a causal role in insulin resistance and suggested that its circulating levels may predict cardiovascular disease. However, the latter assumption has not yet been tested.
  4. doi The metabolic role of retinol binding protein 4: an update
    G A Christou
    Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece
    Horm Metab Res 44:6-14. 2012
    Retinol binding protein 4 (RBP(4)) is regarded as a novel cardiometabolic risk factor, which is secreted mainly by the hepatocytes and also by the adipose tissue...
  5. doi Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 206:239-44. 2009
    Our aim was to examine relations of serum retinol-binding protein 4 (RBP4) to cardiovascular risk factors, and prevalent metabolic syndrome (MetS) and cardiovascular disease (CVD) in a large community-based sample of elderly.
  6. ncbi Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans...
  7. doi Effects of retinol binding protein-4 on vascular endothelial cells
    Kohzo Takebayashi
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Biochem Biophys Res Commun 408:58-64. 2011
    ..The effects of RBP4 on nitric oxide (NO) and insulin-stimulated endothelin-1 (ET-1) secretion and on phosphorylation (p) of Akt, ..
  8. ncbi Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
    M von Eynatten
    Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675, Munich, Germany
    Diabetologia 50:1930-7. 2007
    Retinol-binding protein 4 (RBP4) has recently been reported to be associated with insulin resistance and the metabolic syndrome...
  9. ncbi Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes
    Shai Gavi
    Department of Medicine, Division of General Medicine and Geriatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8154, USA
    J Clin Endocrinol Metab 92:1886-90. 2007
    ..Adipose tissue is responsible for releasing various adipokines that have been related to insulin resistance. Understanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes...
  10. pmc An RBP4 promoter polymorphism increases risk of type 2 diabetes
    M van Hoek
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:1423-8. 2008
    Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance...
  11. pmc Liver retinol transporter and receptor for serum retinol-binding protein (RBP4)
    Philomena Alapatt
    Molecular Medicine Program and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 288:1250-65. 2013
    ..in the small intestine, stored in liver, and secreted into circulation bound to serum retinol-binding protein (RBP4)...
  12. pmc Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study
    Qi Sun
    Departments of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Circulation 127:1938-47. 2013
    Retinol-binding protein 4 (RBP4) may play an important role in the origin of insulin resistance and metabolic syndrome. Few prospective data are available on the relationship between RBP4 and coronary heart disease (CHD)...
  13. doi Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue
    Antonio Salgado-Somoza
    Cardiovascular Division, Sanitary Research Institute, Santiago de Compostela, Spain
    Clin Endocrinol (Oxf) 76:51-8. 2012
    Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD)...
  14. doi Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Hepatology 48:28-37. 2008
    Retinol-binding protein 4 (RBP4) is an adipocytokine associated with insulin resistance (IR)...
  15. ncbi Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 436:356-62. 2005
    ..Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice...
  16. pmc Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism
    Krysten M Farjo
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Mol Cell Biol 32:5103-15. 2012
    Serum retinol-binding protein 4 (RBP4) is the sole specific vitamin A (retinol) transporter in blood. Elevation of serum RBP4 in patients has been linked to cardiovascular disease and diabetic retinopathy...
  17. ncbi High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    Retinol-binding protein 4 (RBP4) is an adipokine that induced insulin resistance in mice, and high plasma RBP4 levels were associated with insulin-resistant states in humans...
  18. doi Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: a potential biomarker identified by proteomics
    Lucie Lorkova
    Institute of Pathological Physiology, Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Oncol Rep 27:318-24. 2012
    ..A-IV confirms previous studies but the identification of significantly decreased levels of RBP4 in ovarian cancer patients represents a novel observation...
  19. doi Retinol-binding protein 4 levels and susceptibility to ischaemic events in men
    Judit Cubedo
    Cardiovascular Research Center CSIC ICCC, Barcelona, Spain Biomedical Research Institute Sant Pau IIB Sant Pau, Barcelona, Spain
    Eur J Clin Invest 44:266-75. 2014
    ..By applying proteomic approaches, we have detected changes in retinol-binding protein 4 (RBP4) in acute new-onset myocardial infarction patients (AMI) and in high-risk patients with heterozygous familial ..
  20. ncbi Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes.
  21. pmc Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits
    Rebekah L Craig
    Division of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences College of Medicine, 4701 West, Markham Street, Little Rock, AR 72205 7199, USA
    Mol Genet Metab 90:338-44. 2007
    Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine that reduced peripheral and hepatic insulin sensitivity and increased hepatic gluconeogenesis...
  22. ncbi Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 92:2764-72. 2007
    ..Recent studies have shown that serum retinol-binding protein 4 (RBP4) levels increase with obesity...
  23. pmc RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
    Pedro M Moraes-Vieira
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 19:512-26. 2014
    ..b>RBP4, a retinol transporter, is elevated in insulin resistance and contributes to increased diabetes risk...
  24. doi Circulating Nampt and RBP4 levels in patients with carotid stenosis undergoing carotid endarterectomy (CEA)
    Gabriela Aust
    Department of Surgery, Research Laboratories and Clinic of Visceral, Transplantation, Thoracic, and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Clin Chim Acta 412:1195-200. 2011
    ..Altered adipokine secretion, including increased production of nicotinamide phosphoribosyltransferase (Nampt) and retinol binding protein 4 (RBP4) may link adipose tissue dysfunction to cardiovascular complications.
  25. pmc Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes
    Yang Xiao
    Diabetes Center, The Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    PLoS ONE 8:e66607. 2013
    The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders...
  26. ncbi Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass
    J Gomez-Ambrosi
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Clin Endocrinol (Oxf) 69:208-15. 2008
    Controversy exists regarding the elevation of serum retinol-binding protein 4 (RBP4) in human obesity and type 2 diabetes mellitus (T2DM)...
  27. ncbi Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia
    Lkhagvasuren Munkhtulga
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hum Genet 120:879-88. 2007
    Increased levels of retinol binding protein 4 (RBP4) in serum is associated with insulin resistance...
  28. doi The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability
    Nikolaos P E Kadoglou
    Department of Vascular Surgery, Medical School, Attikon University General Hospital, Athens, Greece Electronic address
    Atherosclerosis 235:606-12. 2014
    We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and ..
  29. doi Retinol-binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss
    Alexander Tschoner
    Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Obesity (Silver Spring) 16:2439-44. 2008
    Retinol-binding protein 4 (RBP-4) has been reported to be associated with visceral-fat accumulation and parameters of the metabolic syndrome (MetS)...
  30. pmc Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes
    Beverly J Tepper
    Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Clin Biochem 43:320-3. 2010
    To evaluate whether serum RBP4 correlates with gestational diabetes mellitus (GDM) in a cohort of borderline obese (BMI>30) pregnant women.
  31. doi Serum retinol binding protein-4 and neutrophil gelatinase-associated lipocalin are interrelated in pancreatic cancer patients
    Hala O El-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Scand J Clin Lab Invest 72:602-7. 2012
    ..We aimed to determine serum retinol binding protein-4 (RBP-4) and neutophil gelatinase-associated lipocalin (NGAL) levels in pancreatic cancer patients...
  32. pmc Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action
    Rasmus Ribel-Madsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:54-60. 2009
    ..The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the ..
  33. pmc A polymorphism in the retinol binding protein 4 gene is not associated with gestational diabetes mellitus in several different ethnic groups
    Mark Hiraoka
    University of Hawai i, Department of Obstetrics, Gynecology and Women s Health, Honolulu, USA
    Hawaii Med J 70:164-7. 2011
    ....
  34. doi Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children
    D Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Pediatr Obes 6:e345-52. 2011
    Retinol binding protein 4 (RBP4) is a novel adipocytokine that may link obesity and insulin resistance. We aimed to discriminate between primary and secondary associations of RBP4 with obesity and related disease.
  35. pmc Cloning and sequencing of a full length cDNA coding for human retinol-binding protein
    V Colantuoni
    Nucleic Acids Res 11:7769-76. 1983
    ..Southern and Northern blot analysis suggest that the gene is present in one or few copies per haploid genome and is transcribed in a single mRNA species...
  36. doi Retinol-binding protein 4 is an independent factor associated with triglycerides and a determinant of very low-density lipoprotein-apolipoprotein B100 catabolism in type 2 diabetes mellitus
    Bruno Verges
    Department of Endocrinology Diabetology, University Hospital, Dijon, France
    Arterioscler Thromb Vasc Biol 32:3050-7. 2012
    Retinol-binding protein 4 (rbp4) is an adipokine secreted by adipocytes and liver, whose levels are elevated in type 2 diabetes mellitus (T2DM). Plasma levels of rbp4 and triglycerides are strongly correlated in T2DM...
  37. pmc Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children
    Rushika Conroy
    Division of Pediatrics Endocrinology, Children s Hospita of New York, Presbyterian Hospital Columbia University Medical Center, New York, NY 10032, USA
    J Pediatr Endocrinol Metab 24:913-9. 2011
    In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity...
  38. doi Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects
    Jia Wu
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 45:619-22. 2012
    To investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects.
  39. ncbi Macrophages are novel sites of expression and regulation of retinol binding protein-4 (RBP4)
    M Broch
    CIBER CB06 03 Fisiopatologia de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    Physiol Res 59:299-303. 2010
    ..Retinol-binding protein 4 (RBP4) is an adipokine associated with parameters of obesity including insulin resistance indices, body mass index, waist ..
  40. doi Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy
    Sang Hoon Han
    Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Metabolism 58:1523-9. 2009
    ..Recent studies reported that retinol-binding protein 4 (RBP4) is associated with IR, dyslipidemia, and obesity in non-HIV-infected populations...
  41. doi Human RBP4 adipose tissue expression is gender specific and influenced by leptin
    Katarina Kos
    Department of Diabetes and Vascular Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Clin Endocrinol (Oxf) 74:197-205. 2011
    The role of retinol-binding protein-4 (RBP4) in human insulin resistance remains controversial, which may in part be explained by a gender-specific secretion of RBP4 in adipose tissue (AT)...
  42. pmc Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study
    Kyung M Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Am J Clin Nutr 93:19-26. 2011
    Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults.
  43. ncbi A new method for purification of human plasma retinol-binding protein and transthyretin
    Pullakhandam Raghu
    Department of Biophysics, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania, Hyderabad 500 007, India
    Biotechnol Appl Biochem 38:19-24. 2003
    Retinol is transported in the blood bound to a specific carrier protein called retinol-binding protein (RBP), which in turn binds to another protein, transthyretin (TTR), a homotetrameric, thyroid-hormone-transporting protein...
  44. ncbi Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Diabetes Care 29:2457-61. 2006
    ..Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance...
  45. doi RBP4: a controversial adipokine
    Primoz Kotnik
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
    Eur J Endocrinol 165:703-11. 2011
    ..Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance,..
  46. pmc Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone
    Aiwei Yao-Borengasser
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:2590-7. 2007
    Retinol binding protein 4 (RBP4) was recently found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance.
  47. ncbi Plasma retinol binding protein: structure and function of the prototypic lipocalin
    M E Newcomer
    Biochemistry Department, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochim Biophys Acta 1482:57-64. 2000
    In terms of both structure and biological function, retinol binding protein (RBP) is one of the best characterized members of the lipocalin superfamily. The molecular interactions in which RBP participates are described herein.
  48. doi High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus
    Sung Hee Choi
    Division of Endocrinology and Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang Ku, Sungnam City, Gyeonggi do 463 707, South Korea
    J Clin Endocrinol Metab 93:3142-8. 2008
    ..Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established...
  49. doi Elevated serum retinol-binding protein 4 is associated with insulin resistance in older women
    Jun Bin Suh
    Department of Family Medicine, School of Medicine, Korea University Guro Hospital, Seoul, 152 703 Korea
    Metabolism 59:118-22. 2010
    Retinol-binding protein 4 (RBP4), a molecule secreted from adipocytes and hepatocytes, may contribute to insulin resistance and is a potential predictor for type 2 diabetes mellitus...
  50. pmc Retinol-binding protein 4 is associated with prediabetes in adults from the general population: the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study
    Christa Meisinger
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    Diabetes Care 34:1648-50. 2011
    We examined the association between retinol-binding protein 4 (RBP4), a novel adipokine, and prediabetes (isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT], and combined IFG and IGT) in men and women ..
  51. doi Retinol-binding protein-4 in women with untreated essential hypertension
    Anna Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:1001-6. 2009
    Retinol-binding protein-4 (RBP4) is a novel adipokine able to modulate the action of insulin in several tissues. A variable degree of insulin resistance characterizes the vast majority of hypertensive (HYP) patients...
  52. doi Factors that influence retinol-binding protein 4-transthyretin interaction are not altered in overweight subjects and overweight subjects with type 2 diabetes mellitus
    Simone K Frey
    Institute of Nutritional Science, University of Potsdam, D 14558 Nuthetal Potsdam Rehbrücke, Germany
    Metabolism 58:1386-92. 2009
    Retinol-binding protein 4 (RBP4) is an adipokine bound in plasma to transthyretin (TTR), which prevents its glomerular filtration and subsequent catabolism in the kidney...
  53. doi Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI
    Lkhagvasuren Munkhtulga
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University, Tochigi, Japan
    Obesity (Silver Spring) 18:1006-14. 2010
    Retinol-binding protein 4 (RBP4) is a recently identified adipokine that was involved in insulin resistance...
  54. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    ..Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes...
  55. ncbi Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    Nora Kloting
    Department of Internal Medicine III, University of Leipzig, D 04103 Leipzig, Germany
    Cell Metab 6:79-87. 2007
    ..Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D)...
  56. ncbi Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis
    M W Seeliger
    University Eye Hospital, Department II, Tubingen, Germany
    Invest Ophthalmol Vis Sci 40:3-11. 1999
    To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP).
  57. doi The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swed
    V Wallenius
    Department of Gastrosurgical Research, Sahlgrenska Academy at Sahlgrenska University Hospital, Gothenburg, Sweden
    Exp Clin Endocrinol Diabetes 119:75-80. 2011
    The lipocalins retinol-binding protein (RBP)-4, lipocalin-2 and lipocalin-type prostaglandin D-synthase (L-PGDS) have been suggested to mediate obesity-associated insulin resistance and other metabolic co-morbidities...
  58. doi The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes
    Fusun Toruner
    Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Besevler, 06500 Ankara, Turkey
    Diabetes Res Clin Pract 91:203-7. 2011
    Adipocyte fatty acid binding protein-4 (A-FABP4) and retinol binding protein-4 (RBP4) have recently been linked to type 2 diabetes mellitus (DM)...
  59. pmc Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 32:733-5. 2009
    We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD).
  60. doi Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population
    M Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Diabetologia 52:1511-9. 2009
    Increased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes...
  61. pmc Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, Datteln, Germany
    J Clin Endocrinol Metab 93:2287-93. 2008
    There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children.
  62. ncbi Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity
    Michaela Vitkova
    Institut National de la Santé et de la Recherche Médicale Université Paul Sabatier U858, IFR31, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 92:2330-5. 2007
    Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance.
  63. pmc Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels
    Andrea Henze
    Department of Physiology and Pathophysiology of Nutrition, Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    Diabetes 57:3323-6. 2008
    It has been suggested that retinol-binding protein 4 (RBP4) links adiposity, insulin resistance, and type 2 diabetes. However, circulating RBP4 levels are also affected by kidney function...
  64. doi Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Alberto O Chavez
    Diabetes Division, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 296:E758-64. 2009
    Retinol-binding protein-4 (RBP4), a novel protein secreted mainly by adipose tissue, has been associated with insulin resistance in obese subjects and in individuals with type 2 diabetes mellitus (T2DM)...
  65. ncbi Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure
    S Jaconi
    Clinique de Dermatologie, Hopital Cantonal Universitaire, Geneve, Switzerland
    J Lipid Res 36:1247-53. 1995
    Retinol-binding protein (RBP) is the specific blood carrier for the transport of retinol (vitamin A) to target tissues...
  66. ncbi Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
    H K Biesalski
    Department of Biological Chemistry and Nutrition, University Hohenheim, Stuttgart, Germany
    Am J Clin Nutr 69:931-6. 1999
    ..In both siblings, plasma retinol binding protein (RBP) concentrations were below the limit of detection (<0...
  67. pmc Clinical implications of serum retinol-binding protein 4 in asthmatic children
    Yeo Hoon Park
    Department of Pediatrics and Institute of Allergy, BK 21 Project for Medical Sciences, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:1010-4. 2009
    ..Total eosinophil count, serum total IgE, serum eosinophil cationic protein, and serum RBP4 were measured in all subjects...
  68. ncbi Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, 52074 Aachen, Germany
    Diabetes Care 30:1168-72. 2007
    Retinol-binding protein 4 (RBP4) has been identified as a novel adipokine mediating systemic insulin resistance, and elevated serum RBP4 indicates overt or impending insulin resistance in lean, obese, and type 2 diabetic subjects...
  69. ncbi Serum retinol-binding protein 4 is elevated and positively associated with insulin resistance in postmenopausal women
    Chiying An
    Department of Endocrinology, First Clinical Hospital of Harbin Medical University, Harbin, PR China, 150001
    Endocr J 56:987-96. 2009
    Retinol-binding protein 4 (RBP4) is a newly discovered adipokine, which is reported to be correlated with insulin resistance (IR) and type 2 diabetes (T2DM)...
  70. ncbi The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP
    H M Naylor
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 38:2647-53. 1999
    ..or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP)...
  71. doi Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population
    C Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabet Med 25:11-8. 2008
    Retinol binding protein 4 (RBP4) is a newly discovered adipokine, which plays a role in insulin resistance and obesity...
  72. ncbi Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes
    Weiping Jia
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    J Clin Endocrinol Metab 92:3224-9. 2007
    Previous studies have shown that adipose-derived serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant mouse models and in subjects with insulin resistance or type 2 diabetes...
  73. doi Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis
    Matthias J Bahr
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Clin Endocrinol (Oxf) 70:60-5. 2009
    ..This study was designed to determine circulating levels and hepatic production of retinol-binding protein 4 (RBP4) in relation to parameters of hepatic and systemic metabolism in patients with liver cirrhosis.
  74. ncbi Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women
    Ji Won Lee
    Department of Family Medicine, Yonsei University, College of Medicine, Yong Dong Severance Hospital, Kangnam P O Box 1217, Seoul, Korea
    Obesity (Silver Spring) 15:2225-32. 2007
    Retinol binding protein-4 (RBP4) has been reported to impair insulin sensitivity throughout the body. We investigated the relationship between serum RBP4 levels and adiposity indices as well as metabolic risk variables.
  75. pmc Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Dr Josep Trueta Hospital, Girona Institute for Biomedical Research, Girona, Spain
    Diabetes 57:1918-25. 2008
    The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood. An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized...
  76. ncbi Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay
    Urban A Kiernan
    Intrinsic Bioprobes, Inc, Tempe, AZ 85282, USA
    Biochem Biophys Res Commun 297:401-5. 2002
    ..In this work, MSIA is used in the comparative analyses of retinol binding protein (RBP) from the plasma and urine of a small study population...
  77. ncbi Variations of retinol binding protein 4 levels are not associated with changes in insulin resistance during puberty
    N Santoro
    Department of Pediatrics F Fede Second University of Naples, Naples, Italy
    J Endocrinol Invest 32:411-4. 2009
    Retinol binding protein 4 (RBP4) is an adipokine involved in the pathogenesis of insulin resistance in obese adults and children...
  78. ncbi Microalbuminuria is a major determinant of elevated plasma retinol-binding protein 4 in type 2 diabetic patients
    J Raila
    Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    Kidney Int 72:505-11. 2007
    Plasma retinol-binding protein 4 (RBP4) may be a new adipokine linked to obesity-induced insulin resistance and type 2 diabetes. The impact of diabetic nephropathy on plasma RBP4 levels, however, is not known...
  79. pmc Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 13:R112. 2009
    ..Recently, several hormones secreted by adipose tissue have been identified to be involved in overall insulin sensitivity in metabolic syndrome-related conditions. However, little is known about these adipokines in critical illness...
  80. ncbi Serum retinol-binding protein 4 levels in patients with diabetic retinopathy
    Z Z Li
    Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, China
    J Int Med Res 38:95-9. 2010
    Retinol-binding protein 4 (RBP4) has been reported to be involved in the development of insulin resistance and diabetes...
  81. ncbi Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects
    Dominik G Haider
    Medical University of Vienna, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Allgemeines Krankenhaus Wien, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Clin Endocrinol Metab 92:1168-71. 2007
    Administration of retinol-binding protein 4 (RBP-4) impairs insulin sensitivity in animals, and elevated serum concentrations have been associated with insulin resistance in humans.
  82. ncbi Regulation of retinol binding protein 4 production in primary human adipocytes by adiponectin, troglitazone and TNF-alpha
    H Sell
    Diabetologia 50:2221-3. 2007
  83. pmc Retinaldehyde represses adipogenesis and diet-induced obesity
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:695-702. 2007
    ..Here we show that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-gamma and RXR responses...
  84. doi Expression of genes associated with retinoid metabolism in the trout ovarian follicle
    Liraz Levi
    Department of Marine Biology and Biotechnology, Israel Oceanographic and Limnological Research, Haifa, Israel
    Biol Reprod 79:570-7. 2008
    ..Therefore, we investigated the expression of six genes (bcmo1, bcdo2, rbp1, lrat, rbp4, and stra6) associated with retinoids and carotenoids in juvenile and adult trout ovaries...
  85. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    The authors hypothesized that serum retinol-binding protein 4 (RBP4) concentrations will be higher in gestational diabetes mellitus (GDM) subjects...
  86. doi Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease
    Kerry Lee Milner
    Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia
    Hepatology 49:1926-34. 2009
    ..in inflammation, namely adipocyte fatty acid-binding protein (AFABP), lipocalin-2, and retinol-binding protein 4 (RBP4)...
  87. pmc Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis
    Anna K Coussens
    Cooperative Research Centre for Diagnostics, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, Australia
    BMC Genomics 8:458. 2007
    ..Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis...
  88. doi Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4
    Orzala Sharif
    Genomics Institute of the Novartis Research Foundation GNF, San Diego, CA 92121, USA
    Anal Biochem 392:162-8. 2009
    Retinol-binding protein-4 (RBP4) is an emerging candidate drug target for type 2 diabetes and lipofuscin-mediated macular degeneration...
  89. ncbi Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin
    C D Blowe
    Department of Animal Science, North Carolina State University, Raleigh, NC 27695 7621, USA
    J Anim Breed Genet 123:389-95. 2006
    ..1 marker loci coding for genes known to affect litter size: oestrogen receptor (ESR), retinol-binding protein 4 (RBP4) and follistatin (FS)...
  90. ncbi Candidate gene markers for litter size in different German pig lines
    C Drogemuller
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Germany
    J Anim Sci 79:2565-70. 2001
    ..size, the estrogen receptor (ESR) gene, the prolactin receptor (PRLR) gene, and the retinol-binding protein 4 (RBP4) gene, were evaluated for their association with the number of piglets born alive in different German pig lines...
  91. pmc Retinol binding protein 4--a novel association with early-onset preeclampsia
    Edi Vaisbuch
    Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    J Perinat Med 38:129-39. 2010
    ..Retinol binding protein 4 (RBP4), a novel adipokine, plays a role in obesity-related disorders, as well as in the regulation of the immune response...
  92. ncbi Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people
    Qibin Qi
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 92:4827-34. 2007
    High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce.
  93. doi Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance
    D Yeste
    Pediatric Endocrinology Unit, Hospital Maternoinfantil Vall d Hebron, Autonomous University, and CIBER Rare Diseases CIBER ER, Barcelona, Spain
    Horm Res Paediatr 73:335-40. 2010
    Retinol-binding protein 4 (RBP4) is known to be involved in obesity-associated insulin resistance.
  94. doi Current status of liver disease in Korea: nonalcoholic fatty liver disease
    Sang Hoon Park
    Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea
    Korean J Hepatol 15:S34-9. 2009
    ..the regulation of adipokines, such as downregulation of adiponectin and upregulation of retinol-binding protein 4 (RBP4) and ghrelin...
  95. doi Structural modifications of serum transthyretin in rats during protein-energy malnutrition
    Andrea Henze
    University of Potsdam, Institute of Nutritional Science, Department of Physiology and Pathophysiology, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Rapid Commun Mass Spectrom 22:3270-4. 2008
    ..as well as other markers of nutritional status as body weight, food consumption, total serum protein and serum RBP4 levels as well as antioxidative capacity were determined...
  96. doi Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea
    Kun Der Lin
    Graduate Institute of Medicine, Kaohsiung Medical University Hospital, Taiwan
    Transl Res 151:309-14. 2008
    Retinol-binding protein 4 (RBP4) has been found to induce insulin resistance and to be increased in type 2 diabetes...
  97. ncbi Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease
    Ann B Goodman
    The Massachusetts Mental Health Center Academic Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Cell Physiol 209:598-603. 2006
    ..This is the first report to suggest that RBP4 is an amenable treatment target in LOAD...
  98. pmc Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids
    Jan Grünewald
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:4337-42. 2009
    ..Immunization of mice with a pNO(2)Phe(43) mutant of murine retinol-binding protein (RBP4) also elicited a high titer IgG antibody response, which was cross-reactive with wild-type mRBP4...
  99. pmc Retinoic acid enhances osteogenesis in cranial suture-derived mesenchymal cells: potential mechanisms of retinoid-induced craniosynostosis
    Aaron W James
    Hagey Pediatric Regenerative Research Laboratory, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Plast Reconstr Surg 125:1352-61. 2010
    ..The authors used the culture of mouse cranial suture-derived mesenchymal cells to probe the potential cellular mechanisms of this teratogen to better elucidate mechanisms of retinoid-induced suture fusion...
  100. pmc Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
    Ming Fu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 137:631-40. 2010
    ..and that vitamin A depletion causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4(-/-)) mice...
  101. ncbi Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation
    Prabhakaran Balagopal
    Mayo Clinic College of Medicine, and Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    J Clin Endocrinol Metab 92:1971-4. 2007
    Retinol binding protein (RBP4), secreted primarily from the liver and adipose tissues, was recently proposed as a link between obesity and insulin resistance...

Research Grants18

  1. Tissue specific production of RBP4 and mechanism of insulin resistance
    Timothy E Graham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background: Serum retinol binding protein (RBP4) concentrations are elevated in insulin resistant states such as obesity, the metabolic syndrome, and type 2 diabetes, and RBP4 plays a causal role in ..
  2. RBP4-Transthyretin Interactions in Insulin Resistant States
    TIMOTHY EUGENE GRAHAM; Fiscal Year: 2009
    ..We recently discovered that serum retinol binding protein (RBP4) concentrations are elevated in insulin resistant mice and humans...
  3. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..may play a key role in vascular disease, through secretion of adipocytokines, including retinol binding protein 4 (RBP4), adiponectin, and resistin, which are involved in inflammation and insulin resistance...
  4. RBP4, Inflammation, and Insulin Resistance
    JULIE ELIZABETH NORSEEN; Fiscal Year: 2012
    ..Retinol binding protein 4 (RBP4) is elevated in rodents and humans with obesity and insulin resistance...
  5. Stimulated by Retinoic Acid (STra6) in Energy Homeostasis
    LAURA H ZEMANY; Fiscal Year: 2013
    ..Retinol binding protein 4 (RBP4) is elevated in rodents and humans with obesity and insulin resistance...
  6. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara B Kahn; Fiscal Year: 2013
    ..We discovered that adipose expression and serum levels of retinol binding protein 4 (RBP4) are increased in insulin resistant states in humans and rodents In the next cycle, the overall goals will continue ..
  7. DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASE
    Frank B Hu; Fiscal Year: 2013
    ..the brain-adipose axis (leptin, soluble leptin receptor (sOB-R), insulin, adiponectin, retinol binding protein 4 [RBP4], tumor necrosis factor receptor 2 [TNF-R2], and interleukin 6 [IL-6]) among 1,000 healthy NHS II participants who ..
  8. Obesity Genes, Energy Regulation in Response to Weight-Loss Diets
    Lu Qi; Fiscal Year: 2013
    ..biochemical markers of brain-gut- adipose axis, including leptin, insulin, glucose, ghrelin, GLP-1, adiponectin and RBP4;and 4) adipose gene expression profile...
  9. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ..We also will generate compound knockouts lacking both STRA6 and the serum retinol binding protein 4 (RBP4) to test for the hypothesis that RBP4 triggers the pathological alterations seen in STRA6- deficiency...
  10. Small molecule drugs for treatment of dry age-related macular degeneration
    Konstantin Petrukhin; Fiscal Year: 2013
    ..Formation of the tertiary retinol-binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex in serum is required for retinol uptake from circulation to the RPE...
  11. 6th International Symposium on FAP Disorders and 5th...
    Joel Buxbaum; Fiscal Year: 2006
    ..abstract_text> ..
  12. TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICE
    Joel Buxbaum; Fiscal Year: 2004
    ..Investigation of the model may allow us to identify and study such mechanisms which, in turn, may provide insight into aging and offer potential therapeutic targets in more than one form of human amyloidosis. ..
  13. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  15. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  16. FASEB Research Conf: Glucose Transporter Biology
    Barbara Kahn; Fiscal Year: 2003
    ..abstract_text> ..
  17. Discovery of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry
    URBAN KIERNAN; Fiscal Year: 2006
    ..The ultimate result of this research will be a validated protein biomarker assay(s) that can be used to screen for alcohol exposure. [unreadable] [unreadable] [unreadable]..