RBP4

Summary

Gene Symbol: RBP4
Description: retinol binding protein 4, plasma
Alias: RDCCAS, PRBP, RBP, plasma retinol-binding protein, retinol-binding protein 4, retinol-binding protein 4, interstitial
Species: human

Top Publications

  1. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
  2. ncbi Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 436:356-62. 2005
  3. ncbi Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis
    M W Seeliger
    University Eye Hospital, Department II, Tubingen, Germany
    Invest Ophthalmol Vis Sci 40:3-11. 1999
  4. doi High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus
    Sung Hee Choi
    Division of Endocrinology and Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang Ku, Sungnam City, Gyeonggi do 463 707, South Korea
    J Clin Endocrinol Metab 93:3142-8. 2008
  5. doi Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 206:239-44. 2009
  6. doi Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children
    D Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Pediatr Obes 6:e345-52. 2011
  7. doi Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: a potential biomarker identified by proteomics
    Lucie Lorkova
    Institute of Pathological Physiology, Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Oncol Rep 27:318-24. 2012
  8. doi Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Hepatology 48:28-37. 2008
  9. doi Human RBP4 adipose tissue expression is gender specific and influenced by leptin
    Katarina Kos
    Department of Diabetes and Vascular Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Clin Endocrinol (Oxf) 74:197-205. 2011
  10. pmc An RBP4 promoter polymorphism increases risk of type 2 diabetes
    M van Hoek
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:1423-8. 2008

Research Grants

  1. RETINOL BINDING PROTEIN-4 AND INSULIN RESISTANCE
    Timothy Graham; Fiscal Year: 2007
  2. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2010
  3. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2007
  4. RISK FACTORS FOR CVD IN WOMEN
    JoAnn Manson; Fiscal Year: 2009
  5. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2010
  6. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
  7. Dietary Polyphenols, Urinary Biomarkers & Risk of Type 2 Diabetes
    Qi Sun; Fiscal Year: 2010
  8. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
  9. Role of PTP1B in Body Mass Regulation
    Barbara B Kahn; Fiscal Year: 2010
  10. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 1993

Detail Information

Publications170 found, 100 shown here

  1. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
    ..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed...
  2. ncbi Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 436:356-62. 2005
    ..Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice...
  3. ncbi Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis
    M W Seeliger
    University Eye Hospital, Department II, Tubingen, Germany
    Invest Ophthalmol Vis Sci 40:3-11. 1999
    To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP).
  4. doi High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus
    Sung Hee Choi
    Division of Endocrinology and Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang Ku, Sungnam City, Gyeonggi do 463 707, South Korea
    J Clin Endocrinol Metab 93:3142-8. 2008
    ..Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established...
  5. doi Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 206:239-44. 2009
    Our aim was to examine relations of serum retinol-binding protein 4 (RBP4) to cardiovascular risk factors, and prevalent metabolic syndrome (MetS) and cardiovascular disease (CVD) in a large community-based sample of elderly.
  6. doi Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children
    D Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Pediatr Obes 6:e345-52. 2011
    b>Retinol binding protein 4 (RBP4) is a novel adipocytokine that may link obesity and insulin resistance. We aimed to discriminate between primary and secondary associations of RBP4 with obesity and related disease.
  7. doi Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: a potential biomarker identified by proteomics
    Lucie Lorkova
    Institute of Pathological Physiology, Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Oncol Rep 27:318-24. 2012
    ..A-IV confirms previous studies but the identification of significantly decreased levels of RBP4 in ovarian cancer patients represents a novel observation...
  8. doi Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Hepatology 48:28-37. 2008
    Retinol-binding protein 4 (RBP4) is an adipocytokine associated with insulin resistance (IR)...
  9. doi Human RBP4 adipose tissue expression is gender specific and influenced by leptin
    Katarina Kos
    Department of Diabetes and Vascular Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Clin Endocrinol (Oxf) 74:197-205. 2011
    The role of retinol-binding protein-4 (RBP4) in human insulin resistance remains controversial, which may in part be explained by a gender-specific secretion of RBP4 in adipose tissue (AT)...
  10. pmc An RBP4 promoter polymorphism increases risk of type 2 diabetes
    M van Hoek
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:1423-8. 2008
    Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance...
  11. doi Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy
    Sang Hoon Han
    Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Metabolism 58:1523-9. 2009
    ..Recent studies reported that retinol-binding protein 4 (RBP4) is associated with IR, dyslipidemia, and obesity in non-HIV-infected populations...
  12. doi Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects
    Jia Wu
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 45:619-22. 2012
    To investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects.
  13. ncbi A new method for purification of human plasma retinol-binding protein and transthyretin
    Pullakhandam Raghu
    Department of Biophysics, National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania, Hyderabad 500 007, India
    Biotechnol Appl Biochem 38:19-24. 2003
    Retinol is transported in the blood bound to a specific carrier protein called retinol-binding protein (RBP), which in turn binds to another protein, transthyretin (TTR), a homotetrameric, thyroid-hormone-transporting protein...
  14. ncbi Macrophages are novel sites of expression and regulation of retinol binding protein-4 (RBP4)
    M Broch
    CIBER CB06 03 Fisiopatologia de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
    Physiol Res 59:299-303. 2010
    ..Retinol-binding protein 4 (RBP4) is an adipokine associated with parameters of obesity including insulin resistance indices, body mass index, waist ..
  15. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    ..b>Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and ..
  16. pmc Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study
    Kyung M Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Am J Clin Nutr 93:19-26. 2011
    Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults.
  17. ncbi Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    Nora Kloting
    Department of Internal Medicine III, University of Leipzig, D 04103 Leipzig, Germany
    Cell Metab 6:79-87. 2007
    ..Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D)...
  18. pmc Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, Datteln, Germany
    J Clin Endocrinol Metab 93:2287-93. 2008
    There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children.
  19. doi Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population
    M Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Diabetologia 52:1511-9. 2009
    Increased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes...
  20. ncbi Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity
    Michaela Vitkova
    Institut National de la Santé et de la Recherche Médicale Université Paul Sabatier U858, IFR31, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 92:2330-5. 2007
    Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance.
  21. ncbi Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, 52074 Aachen, Germany
    Diabetes Care 30:1168-72. 2007
    Retinol-binding protein 4 (RBP4) has been identified as a novel adipokine mediating systemic insulin resistance, and elevated serum RBP4 indicates overt or impending insulin resistance in lean, obese, and type 2 diabetic subjects...
  22. pmc Clinical implications of serum retinol-binding protein 4 in asthmatic children
    Yeo Hoon Park
    Department of Pediatrics and Institute of Allergy, BK 21 Project for Medical Sciences, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:1010-4. 2009
    ..Total eosinophil count, serum total IgE, serum eosinophil cationic protein, and serum RBP4 were measured in all subjects...
  23. pmc Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels
    Andrea Henze
    Department of Physiology and Pathophysiology of Nutrition, Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    Diabetes 57:3323-6. 2008
    It has been suggested that retinol-binding protein 4 (RBP4) links adiposity, insulin resistance, and type 2 diabetes. However, circulating RBP4 levels are also affected by kidney function...
  24. ncbi Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
    H K Biesalski
    Department of Biological Chemistry and Nutrition, University Hohenheim, Stuttgart, Germany
    Am J Clin Nutr 69:931-6. 1999
    ..In both siblings, plasma retinol binding protein (RBP) concentrations were below the limit of detection (<0...
  25. ncbi Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure
    S Jaconi
    Clinique de Dermatologie, Hopital Cantonal Universitaire, Geneve, Switzerland
    J Lipid Res 36:1247-53. 1995
    Retinol-binding protein (RBP) is the specific blood carrier for the transport of retinol (vitamin A) to target tissues...
  26. doi Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Alberto O Chavez
    Diabetes Division, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 296:E758-64. 2009
    Retinol-binding protein-4 (RBP4), a novel protein secreted mainly by adipose tissue, has been associated with insulin resistance in obese subjects and in individuals with type 2 diabetes mellitus (T2DM)...
  27. pmc Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 32:733-5. 2009
    We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD).
  28. pmc Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action
    Rasmus Ribel-Madsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:54-60. 2009
    ..The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the ..
  29. ncbi Serum retinol-binding protein 4 is elevated and positively associated with insulin resistance in postmenopausal women
    Chiying An
    Department of Endocrinology, First Clinical Hospital of Harbin Medical University, Harbin, PR China, 150001
    Endocr J 56:987-96. 2009
    Retinol-binding protein 4 (RBP4) is a newly discovered adipokine, which is reported to be correlated with insulin resistance (IR) and type 2 diabetes (T2DM)...
  30. ncbi The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP
    H M Naylor
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 38:2647-53. 1999
    ..or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP)...
  31. doi Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population
    C Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabet Med 25:11-8. 2008
    b>Retinol binding protein 4 (RBP4) is a newly discovered adipokine, which plays a role in insulin resistance and obesity...
  32. pmc Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload
    Jose Manuel Fernandez-Real
    Diabetes, Endocrinology, and Nutrition Unit, Dr Josep Trueta Hospital, Girona Institute for Biomedical Research, Girona, Spain
    Diabetes 57:1918-25. 2008
    The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood. An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized...
  33. ncbi Variations of retinol binding protein 4 levels are not associated with changes in insulin resistance during puberty
    N Santoro
    Department of Pediatrics F Fede Second University of Naples, Naples, Italy
    J Endocrinol Invest 32:411-4. 2009
    b>Retinol binding protein 4 (RBP4) is an adipokine involved in the pathogenesis of insulin resistance in obese adults and children...
  34. ncbi Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes
    Weiping Jia
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    J Clin Endocrinol Metab 92:3224-9. 2007
    Previous studies have shown that adipose-derived serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant mouse models and in subjects with insulin resistance or type 2 diabetes...
  35. ncbi Microalbuminuria is a major determinant of elevated plasma retinol-binding protein 4 in type 2 diabetic patients
    J Raila
    Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    Kidney Int 72:505-11. 2007
    Plasma retinol-binding protein 4 (RBP4) may be a new adipokine linked to obesity-induced insulin resistance and type 2 diabetes. The impact of diabetic nephropathy on plasma RBP4 levels, however, is not known...
  36. ncbi Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes
    Anita Ost
    Department of Cell Biology and Diabetes Research Centre, Linkoping University, SE58185 Linköping, Sweden
    FASEB J 21:3696-704. 2007
    ..Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-binding protein (RBP4), and RBP4 can induce insulin resistance in mice. However, little is known about how RBP4 affects insulin signaling...
  37. ncbi Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes
    Shai Gavi
    Department of Medicine, Division of General Medicine and Geriatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8154, USA
    J Clin Endocrinol Metab 92:1886-90. 2007
    ..Adipose tissue is responsible for releasing various adipokines that have been related to insulin resistance. Understanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes...
  38. ncbi Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women
    Ji Won Lee
    Department of Family Medicine, Yonsei University, College of Medicine, Yong Dong Severance Hospital, Kangnam P O Box 1217, Seoul, Korea
    Obesity (Silver Spring) 15:2225-32. 2007
    Retinol binding protein-4 (RBP4) has been reported to impair insulin sensitivity throughout the body. We investigated the relationship between serum RBP4 levels and adiposity indices as well as metabolic risk variables.
  39. doi Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women
    Ziad Mallat
    Institut National de la Santé et de la Recherche Médicale Unit 689, Hopital Lariboisiere, 75010 Paris, France
    J Clin Endocrinol Metab 94:255-60. 2009
    Recent studies reported that retinol-binding protein 4 (RBP4) has a causal role in insulin resistance and suggested that its circulating levels may predict cardiovascular disease. However, the latter assumption has not yet been tested.
  40. pmc Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
    Lies Langouche
    Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 13:R112. 2009
    ..Recently, several hormones secreted by adipose tissue have been identified to be involved in overall insulin sensitivity in metabolic syndrome-related conditions. However, little is known about these adipokines in critical illness...
  41. doi Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis
    Matthias J Bahr
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Clin Endocrinol (Oxf) 70:60-5. 2009
    ..This study was designed to determine circulating levels and hepatic production of retinol-binding protein 4 (RBP4) in relation to parameters of hepatic and systemic metabolism in patients with liver cirrhosis.
  42. ncbi Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Diabetes Care 29:2457-61. 2006
    ..Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance...
  43. ncbi Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects
    Dominik G Haider
    Medical University of Vienna, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Allgemeines Krankenhaus Wien, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Clin Endocrinol Metab 92:1168-71. 2007
    Administration of retinol-binding protein 4 (RBP-4) impairs insulin sensitivity in animals, and elevated serum concentrations have been associated with insulin resistance in humans.
  44. ncbi Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay
    Urban A Kiernan
    Intrinsic Bioprobes, Inc, Tempe, AZ 85282, USA
    Biochem Biophys Res Commun 297:401-5. 2002
    ..In this work, MSIA is used in the comparative analyses of retinol binding protein (RBP) from the plasma and urine of a small study population...
  45. ncbi High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    Retinol-binding protein 4 (RBP4) is an adipokine that induced insulin resistance in mice, and high plasma RBP4 levels were associated with insulin-resistant states in humans...
  46. pmc Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits
    Rebekah L Craig
    Division of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences College of Medicine, 4701 West, Markham Street, Little Rock, AR 72205 7199, USA
    Mol Genet Metab 90:338-44. 2007
    Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine that reduced peripheral and hepatic insulin sensitivity and increased hepatic gluconeogenesis...
  47. ncbi Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 92:2764-72. 2007
    ..Recent studies have shown that serum retinol-binding protein 4 (RBP4) levels increase with obesity...
  48. ncbi Serum retinol-binding protein 4 levels in patients with diabetic retinopathy
    Z Z Li
    Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, China
    J Int Med Res 38:95-9. 2010
    Retinol-binding protein 4 (RBP4) has been reported to be involved in the development of insulin resistance and diabetes...
  49. ncbi Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans...
  50. ncbi Regulation of retinol binding protein 4 production in primary human adipocytes by adiponectin, troglitazone and TNF-alpha
    H Sell
    Diabetologia 50:2221-3. 2007
  51. ncbi Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
    M von Eynatten
    Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675, Munich, Germany
    Diabetologia 50:1930-7. 2007
    Retinol-binding protein 4 (RBP4) has recently been reported to be associated with insulin resistance and the metabolic syndrome...
  52. pmc Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone
    Aiwei Yao-Borengasser
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:2590-7. 2007
    b>Retinol binding protein 4 (RBP4) was recently found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance.
  53. doi Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI
    Lkhagvasuren Munkhtulga
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University, Tochigi, Japan
    Obesity (Silver Spring) 18:1006-14. 2010
    Retinol-binding protein 4 (RBP4) is a recently identified adipokine that was involved in insulin resistance...
  54. ncbi Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia
    Lkhagvasuren Munkhtulga
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hum Genet 120:879-88. 2007
    Increased levels of retinol binding protein 4 (RBP4) in serum is associated with insulin resistance...
  55. ncbi Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes.
  56. pmc Retinaldehyde represses adipogenesis and diet-induced obesity
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:695-702. 2007
    ..Here we show that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-gamma and RXR responses...
  57. doi Expression of genes associated with retinoid metabolism in the trout ovarian follicle
    Liraz Levi
    Department of Marine Biology and Biotechnology, Israel Oceanographic and Limnological Research, Haifa, Israel
    Biol Reprod 79:570-7. 2008
    ..Therefore, we investigated the expression of six genes (bcmo1, bcdo2, rbp1, lrat, rbp4, and stra6) associated with retinoids and carotenoids in juvenile and adult trout ovaries...
  58. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    The authors hypothesized that serum retinol-binding protein 4 (RBP4) concentrations will be higher in gestational diabetes mellitus (GDM) subjects...
  59. pmc Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis
    Anna K Coussens
    Cooperative Research Centre for Diagnostics, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, Australia
    BMC Genomics 8:458. 2007
    ..Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis...
  60. doi Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease
    Kerry Lee Milner
    Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia
    Hepatology 49:1926-34. 2009
    ..in inflammation, namely adipocyte fatty acid-binding protein (AFABP), lipocalin-2, and retinol-binding protein 4 (RBP4)...
  61. ncbi Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin
    C D Blowe
    Department of Animal Science, North Carolina State University, Raleigh, NC 27695 7621, USA
    J Anim Breed Genet 123:389-95. 2006
    ..1 marker loci coding for genes known to affect litter size: oestrogen receptor (ESR), retinol-binding protein 4 (RBP4) and follistatin (FS)...
  62. ncbi Candidate gene markers for litter size in different German pig lines
    C Drogemuller
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Germany
    J Anim Sci 79:2565-70. 2001
    ..size, the estrogen receptor (ESR) gene, the prolactin receptor (PRLR) gene, and the retinol-binding protein 4 (RBP4) gene, were evaluated for their association with the number of piglets born alive in different German pig lines...
  63. doi Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4
    Orzala Sharif
    Genomics Institute of the Novartis Research Foundation GNF, San Diego, CA 92121, USA
    Anal Biochem 392:162-8. 2009
    Retinol-binding protein-4 (RBP4) is an emerging candidate drug target for type 2 diabetes and lipofuscin-mediated macular degeneration...
  64. ncbi Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people
    Qibin Qi
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 92:4827-34. 2007
    High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce.
  65. pmc Retinol binding protein 4--a novel association with early-onset preeclampsia
    Edi Vaisbuch
    Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    J Perinat Med 38:129-39. 2010
    ..b>Retinol binding protein 4 (RBP4), a novel adipokine, plays a role in obesity-related disorders, as well as in the regulation of ..
  66. doi Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea
    Kun Der Lin
    Graduate Institute of Medicine, Kaohsiung Medical University Hospital, Taiwan
    Transl Res 151:309-14. 2008
    Retinol-binding protein 4 (RBP4) has been found to induce insulin resistance and to be increased in type 2 diabetes...
  67. doi Structural modifications of serum transthyretin in rats during protein-energy malnutrition
    Andrea Henze
    University of Potsdam, Institute of Nutritional Science, Department of Physiology and Pathophysiology, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Rapid Commun Mass Spectrom 22:3270-4. 2008
    ..as well as other markers of nutritional status as body weight, food consumption, total serum protein and serum RBP4 levels as well as antioxidative capacity were determined...
  68. doi Current status of liver disease in Korea: nonalcoholic fatty liver disease
    Sang Hoon Park
    Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea
    Korean J Hepatol 15:S34-9. 2009
    ..the regulation of adipokines, such as downregulation of adiponectin and upregulation of retinol-binding protein 4 (RBP4) and ghrelin...
  69. doi Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance
    D Yeste
    Pediatric Endocrinology Unit, Hospital Maternoinfantil Vall d Hebron, Autonomous University, and CIBER Rare Diseases CIBER ER, Barcelona, Spain
    Horm Res Paediatr 73:335-40. 2010
    Retinol-binding protein 4 (RBP4) is known to be involved in obesity-associated insulin resistance...
  70. ncbi Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease
    Ann B Goodman
    The Massachusetts Mental Health Center Academic Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Cell Physiol 209:598-603. 2006
    ..This is the first report to suggest that RBP4 is an amenable treatment target in LOAD...
  71. pmc Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
    Ming Fu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 137:631-40. 2010
    ..and that vitamin A depletion causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4(-/-)) mice...
  72. pmc Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids
    Jan Grünewald
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:4337-42. 2009
    ..Immunization of mice with a pNO(2)Phe(43) mutant of murine retinol-binding protein (RBP4) also elicited a high titer IgG antibody response, which was cross-reactive with wild-type mRBP4...
  73. pmc Retinoic acid enhances osteogenesis in cranial suture-derived mesenchymal cells: potential mechanisms of retinoid-induced craniosynostosis
    Aaron W James
    Hagey Pediatric Regenerative Research Laboratory, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Plast Reconstr Surg 125:1352-61. 2010
    ..The authors used the culture of mouse cranial suture-derived mesenchymal cells to probe the potential cellular mechanisms of this teratogen to better elucidate mechanisms of retinoid-induced suture fusion...
  74. pmc Retinol-binding protein levels are increased in association with gonadotropin levels in healthy women
    Hideo Makimura
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Metabolism 58:479-87. 2009
    Recent studies have demonstrated an association between retinol-binding protein (RBP4) and insulin resistance. Retinol-binding protein is decreased in women and elevated in polycystic ovary syndrome...
  75. ncbi Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation
    Prabhakaran Balagopal
    Mayo Clinic College of Medicine, and Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    J Clin Endocrinol Metab 92:1971-4. 2007
    Retinol binding protein (RBP4), secreted primarily from the liver and adipose tissues, was recently proposed as a link between obesity and insulin resistance...
  76. ncbi Elevated level of serum retinol-binding protein 4 in pregnancy-induced hypertension
    Seiji Inoue
    Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    J Obstet Gynaecol Res 35:293-300. 2009
    ..Retinol-binding protein 4 (RBP4), a protein expressed and secreted by adipocytes, has been identified as a novel regulator of insulin resistance...
  77. pmc Retinol binding protein 4: an adipokine associated with intra-amniotic infection/inflammation
    Edi Vaisbuch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:111-9. 2010
    b>Retinol binding protein 4 (RBP4), a specific carrier for retinol in the blood, is a novel adipokine that has been implicated in the pathophysiology of insulin resistance, and its gene expression has been associated with adipose tissue ..
  78. ncbi Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus
    Wei Zhang
    Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
    Chin Med J (Engl) 121:2124-8. 2008
    b>Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship ..
  79. doi Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction
    Masami Sasaki
    Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 357 0111, Japan Hannou Municipal Naguri Clinic, Saitama, Japan
    Metabolism 59:527-32. 2010
    The present study was undertaken to determine plasma retinol-binding protein 4 (RBP4) and adiponectin levels in subjects with cerebral infarction...
  80. doi Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands
    Peter Coward
    Department of Metabolic Disorders, Amgen, South San Francisco, CA 94080, USA
    Anal Biochem 384:312-20. 2009
    b>Retinol binding protein 4 (RBP4) is a serum protein that serves as the major transport protein for retinol (vitamin A)...
  81. doi Role of (-)-epigallocatechin-3-gallate in cell viability, lipogenesis, and retinol-binding protein 4 expression in adipocytes
    Hye Young Sung
    Department of Physiology, Keimyung University School of Medicine, Dalseo Gu, Daegu, South Korea
    Naunyn Schmiedebergs Arch Pharmacol 382:303-10. 2010
    ..and adiponectin in 3T3-L1 adipocytes, as well as the protein level and secretion of plasma retinol-binding protein (RBP4) in human adipocytes, were measured by western blot...
  82. doi Elevated serum gamma-glutamyltransferase levels are independently associated with insulin resistance in non-diabetic subjects
    Jang Yel Shin
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
    Diabetes Res Clin Pract 84:152-7. 2009
    ..We investigated the associations of gamma-glutamyltransferase (GGT) with visceral obesity, adiponectin and retinol binding protein 4 (RBP4), and insulin resistance (IR) and compared these associations with other liver enzymes in non-..
  83. doi Retinol-binding protein 4 is associated with insulin resistance, but appears unsuited for metabolic screening in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
    Eur J Endocrinol 158:517-23. 2008
    ..Retinol-binding protein 4 (RBP4) secreted from adipose and liver tissues has been linked to IR...
  84. pmc Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease
    J A Seo
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Clin Endocrinol (Oxf) 68:555-60. 2008
    Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states...
  85. ncbi [Relationship of genetic polymorphism of PRLR and RBP4 genes with litter size traits in pig]
    Yan Xiao Sun
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an 271018, China
    Yi Chuan 31:63-8. 2009
    The polymorphism of prolactin receptor (PRLR) and retinol-binding protein 4 (RBP4) genes was detected by PCR-RFLP method, and the effects of PRLR and RBP4 genes on litter size traits in pig were analyzed by the least square analysis...
  86. pmc Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis
    Frederic Preitner
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 297:E1420-9. 2009
    ..Retinol-binding protein-4 (RBP4) knockout mice were also fed the HFD with or without FEN in a preventive study...
  87. doi Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    Br J Nutr 101:1145-9. 2009
    Elevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus...
  88. pmc Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness
    Aiwei Yao-Borengasser
    Research, 598 151, Central Arkansas Veterans Healthcare System, Department of Medicine, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4431-9. 2008
    ..SCD-deficient mice are protected from obesity, and the ob/ob mouse has high levels of SCD. This study was designed to better characterize SCD1 gene and protein expression in humans with varying insulin sensitivity...
  89. doi Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 71:351-7. 2009
    ..We explored whether low-dose pioglitazone (Pio) and flutamide (Flu) has readily detectable add-on effects...
  90. doi Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2
    Samreen Riaz
    School of Biological Sciences, University of the Punjab, Lahore, Pakistan
    J Pharm Biomed Anal 54:817-25. 2011
    ..levels of transthyretin, AMBP, haptoglobin precursor were found to decrease while albumin, zinc α 2 glycoprotein, RBP4 and E cadherin were found to increase in the diabetic patients as compared to the controls...
  91. pmc Retinol-binding protein 4: a novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus
    Shali Mazaki-Tovi
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Perinat Med 38:147-55. 2010
    ..Retinol-binding protein 4 (RBP4), only recently recognized as an adipokine, has been proposed to modulate systemic insulin sensitivity...
  92. ncbi [Effects of multi-genes for reproductive traits in Tibet pig]
    Xuan Liu
    College of Animal Science and Technology, China Agricultural University, Bejing 100193, China
    Yi Chuan 32:480-5. 2010
    ..of estrogen receptor (ESR), follicle-stimulating hormone (FSHb), prolactin receptor (PRLR), and retinol binding protein 4 (RBP4) in Tibet pig and to analyze the effects of these variants and their combination genotypes on ..
  93. doi Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice
    Xing Xian Yu
    Department of Antisense Drug Discovery, Isis Pharmaceuticals, 1896 Rutherford Rd, Carlsbad, CA 92008, USA
    Am J Physiol Endocrinol Metab 295:E436-45. 2008
    ..levels of AR-beta(3) and UCP1 by >60% in BAT, 2) reduced mRNA levels of ACC1, ACC2, FAS, SCD1, DGAT1, DGAT2, and RBP4 by 30-60% in WAT, and 3) reduced mRNA levels of ACC1, FAS, G-6-Pase, and PKCepsilon by 40-70% and increased levels ..
  94. doi Vitamin A deficiency in an infant with PAGOD syndrome
    Ralitza Gavrilova
    Department of Medical Genetics, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Med Genet A 149:2241-7. 2009
    ..During pregnancy maternal vitamin A is taken up by retinol binding protein 4 (RBP4) which is expressed in the embryonic visceral endoderm from pregastrulational stages...
  95. ncbi Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes
    J Berndt
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103, Leipzig, Germany
    Diabetologia 50:1472-80. 2007
    ..In the present study we tested the hypothesis that increased FASN expression links metabolic alterations of excess energy intake, including hyperinsulinaemia, dyslipidaemia and altered adipokine profile to increased body fat mass...
  96. pmc Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz
    Julie Hull-Thompson
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Genet 5:e1000460. 2009
    ..Lipocalin family member Neural Lazarillo (NLaz), a homologue of vertebrate Apolipoprotein D (ApoD) and Retinol Binding Protein 4 (RBP4)...
  97. doi Effects of rosuvastatin and colestimide on metabolic parameters and urinary monocyte chemoattractant protein-1 in type 2 diabetic patients with hyperlipidemia
    Kohzo Takebayashi
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    South Med J 102:361-8. 2009
    ....
  98. doi Genetic structure of candidate genes for litter size in Italian Large White pigs
    S Dall'Olio
    Dipartimento di Protezione e Valorizzazione Agroalimentare, Universita degli Studi di Bologna, Sezione di Allevamenti Zootecnici, Reggio Emilia, Italy
    Vet Res Commun 34:S203-6. 2010
    ..The remaining seven markers were polymorphic with minor allele frequencies ranging from 0.10 (AFP) to 0.48 (RBP4)...
  99. doi Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle
    Camilla Alexanderson
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Endocrinol 201:49-58. 2009
    ..increased the expression of genes encoding complement component 3 (C3), Mcp-1, retinol binding protein-4 (Rbp4) and transforming growth factor beta1 (Tgfbeta1)...
  100. ncbi Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease
    Josef V Silha
    Department of Internal Medicine, University of Manitoba, 715 McDermot Avenue, Winnipeg, R3E 3P4 Canada
    Diabetes Care 30:286-91. 2007
    ..We sought to compare the relationship between body composition, insulin resistance, and inflammatory adipokines in Aboriginal Canadian women, who are at high risk of vascular disease, with white women...
  101. ncbi A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24
    I C Gray
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, England
    Genomics 28:328-32. 1995
    ..The map also includes an adjacent gene, the serum retinol binding protein gene (RBP4)...

Research Grants57

  1. RETINOL BINDING PROTEIN-4 AND INSULIN RESISTANCE
    Timothy Graham; Fiscal Year: 2007
    ..We used Affymetrix global gene analysis to identify retinol binding protein-4 (RBP4) as a candidate molecule for mediating systemic insulin resistance in this model...
  2. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2010
    ..We also will generate compound knockouts lacking both STRA6 and the serum retinol binding protein 4 (RBP4) to test for the hypothesis that RBP4 triggers the pathological alterations seen in STRA6-..
  3. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2007
    ..mice, we identified such a protein that is elevated in serum of insulin-resistant rodents and humans, retinol binding protein 4 (RBP4). We demonstrated that RBP4 causes insulin resistance in normal mice...
  4. RISK FACTORS FOR CVD IN WOMEN
    JoAnn Manson; Fiscal Year: 2009
    ..Adipose tissue may play a key role in vascular disease, through secretion of adipocytokines, including retinol binding protein 4 (RBP4), adiponectin, and resistin, which are involved in inflammation and insulin resistance...
  5. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2010
    ..Adipose tissue may play a key role in vascular disease, through secretion of adipocytokines, including retinol binding protein 4 (RBP4), adiponectin, and resistin, which are involved in inflammation and insulin resistance...
  6. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..Our aim is to identify the best supplement that can prevent hypoglycemia and its unwanted consequences in these young women-an under-studied patient population. ..
  7. Dietary Polyphenols, Urinary Biomarkers & Risk of Type 2 Diabetes
    Qi Sun; Fiscal Year: 2010
    ..Findings of the proposed application can be used to develop more effective dietary advice and to make changes in food composition to contribute to the prevention of type 2 diabetes. ..
  8. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ....
  9. Role of PTP1B in Body Mass Regulation
    Barbara B Kahn; Fiscal Year: 2010
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  10. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 1993
    ..These studies will increase our understanding of the cellular and molecular mechanisms underlying the insulin resistance of obesity and diabetes and the link between obesity and Type II diabetes...
  11. Role of PTP1B in Body Mass Regulation
    Barbara Kahn; Fiscal Year: 2009
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  12. Role of PTP1B in Body Mass Regulation
    Barbara Kahn; Fiscal Year: 2007
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  13. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2000
    ....
  14. FASEB Research Conf: Glucose Transporter Biology
    Barbara Kahn; Fiscal Year: 2003
    ..abstract_text> ..
  15. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  16. INTEGRATED ENDOCRINE AND METABOLIC RESEARCH TRAINING
    Barbara Kahn; Fiscal Year: 2007
    ..The program has further formalized its curriculum in the responsible and ethical conduct of research. The success of the trainees reflects the outstanding quality of this Endocrine Training Program ..
  17. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  18. Discovery of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry
    URBAN KIERNAN; Fiscal Year: 2006
    ..The ultimate result of this research will be a validated protein biomarker assay(s) that can be used to screen for alcohol exposure. ..
  19. MS based approaches for diabetes biomarker discovery
    URBAN KIERNAN; Fiscal Year: 2007
    ..The ultimate result of this research will be validated protein biomarkers for pre-and type 2 diabetes and technology that are ready for clinical screening and diagnosis of the disease. ..