RBMX

Summary

Gene Symbol: RBMX
Description: RNA binding motif protein X-linked
Alias: HNRNPG, HNRPG, MRXS11, RBMXP1, RBMXRT, RNMX, hnRNP-G, RNA-binding motif protein, X chromosome, glycoprotein p43, heterogeneous nuclear ribonucleoprotein G, hnRNP G
Species: human
Products:     RBMX

Top Publications

  1. Lingenfelter P, Delbridge M, Thomas S, Hoekstra H, Mitchell M, Graves J, et al. Expression and conservation of processed copies of the RBMX gene. Mamm Genome. 2001;12:538-45 pubmed
    b>RBMX and RBMY are members of an ancient pair of genes located on the sex chromosomes that encode RNA-binding proteins involved in splicing. These genes have differentiated and evolved separately on the X and Y Chromosomes...
  2. Mazeyrat S, Saut N, Mattei M, Mitchell M. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nat Genet. 1999;22:224-6 pubmed
  3. Heinrich B, Zhang Z, Raitskin O, Hiller M, Benderska N, Hartmann A, et al. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. J Biol Chem. 2009;284:14303-15 pubmed publisher
    ..Here we characterize hnRNP G, a member of the hnRNP class of proteins...
  4. Shin K, Kim R, Kang M, Kim R, Kim S, Lim P, et al. p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G. DNA Repair (Amst). 2007;6:830-40 pubmed
    ..The DNA end-protection assay revealed the association of a protein complex including heterogeneous nuclear ribonucleoprotein G (hnRNP G) with the DNA ends in RKO cells containing wt p53, but not with the DNA ends in RKO ..
  5. Renieri A, Mencarelli M, Cetta F, Baldassarri M, Mari F, Furini S, et al. Oligogenic germline mutations identified in early non-smokers lung adenocarcinoma patients. Lung Cancer. 2014;85:168-74 pubmed publisher
    ..identified in other human cancers (JAK2, TCEB3C, NELFE, TAF1B, EBLN2), in mouse models (GON4L, NOP58, and RBMX) or in genome-wide association studies (KIAA2018, ZNF311)...
  6. Elliott D, Dalgliesh C, Hysenaj G, Ehrmann I. RBMX family proteins connect the fields of nuclear RNA processing, disease and sex chromosome biology. Int J Biochem Cell Biol. 2018;108:1-6 pubmed publisher
    b>RBMX is a ubiquitously expressed nuclear RNA binding protein that is encoded by a gene on the X chromosome...
  7. Munschauer M, Nguyen C, Sirokman K, Hartigan C, Hogstrom L, Engreitz J, et al. The NORAD lncRNA assembles a topoisomerase complex critical for genome stability. Nature. 2018;561:132-136 pubmed publisher
    ..In particular, NORAD interacts with RBMX, a component of the DNA-damage response, and contains the strongest RBMX-binding site in the transcriptome...
  8. Dai M, Liu Y, Nie X, Zhang J, Wang Y, Ben J, et al. Expression of RBMX in the light-induced damage of rat retina in vivo. Cell Mol Neurobiol. 2015;35:463-71 pubmed publisher
    RNA-binding motif protein, X-linked (RBMX) is a 43 kDa nuclear protein in the RBM family and functions on alternative splicing of RNA. The gene encoding RBMX is located on chromosome Xq26...
  9. Leng L, Tan Y, Gong F, Hu L, Ouyang Q, Zhao Y, et al. Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency. Hum Reprod. 2015;30:737-48 pubmed publisher
    ..of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), and RNA binding motif protein, X-linked (RBMX), genes located in the deleted region of the X chromosome and that are highly expressed in differentiated germ ..

More Information

Publications40

  1. Correia L, Gamble T, Landell M, Mott T. Indels ascertain the phylogenetic position of Coleodactylus elizae Gonçalves, Torquato, Skuk & Sena, 2012 (Gekkota: Sphaerodactylidae). Zootaxa. 2016;4084:147-50 pubmed publisher
    ..2008a; Geurgas et al. 2008), while Chatogekko has a unique three bp deletion in the RBMX gene and a three bp deletion in the protein tyrosine phosphatase nonreceptor type 12 gene (PTPN12) (Gamble et al...
  2. Becker J, McCarthy R, Sidoli S, Donahue G, Kaeding K, He Z, et al. Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Mol Cell. 2017;68:1023-1037.e15 pubmed publisher
    ..Our proteomics of H3K9me3-marked srHC and functional screens revealed diverse proteins, including RBMX and RBMXL1, that impede gene induction during cellular reprogramming...
  3. Fan W, Chang S, Shan X, Gao D, Zhang S, Zhang J, et al. Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16. Mol Med Rep. 2016;14:4099-4108 pubmed publisher
    ..Several genes, including CXCL12, BAI1, ZIC2, RBMX, RASSF6, MAGE?A6 and HOX, were identified as significant DEGs...
  4. Kanhoush R, Beenders B, Perrin C, Moreau J, Bellini M, Penrad Mobayed M. Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Nucleus. 2010;1:109-22 pubmed publisher
    The heterogenous nuclear ribonucleoprotein G (hnRNP G) controls the alternative splicing of several pre-mRNas...
  5. Matsunaga S, Takata H, Morimoto A, Hayashihara K, Higashi T, Akatsuchi K, et al. RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion. Cell Rep. 2012;1:299-308 pubmed publisher
    ..Here, we have demonstrated that an RNA-binding motif protein encoded on the X chromosome (RBMX) plays an essential role in chromosome morphogenesis through its association with chromatin, but not with RNA...
  6. Delbridge M, Lingenfelter P, Disteche C, Graves J. The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome. Nat Genet. 1999;22:223-4 pubmed
  7. Nasim M, Chernova T, Chowdhury H, Yue B, Eperon I. HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding. Hum Mol Genet. 2003;12:1337-48 pubmed
    The hnRNP G family comprises three closely related proteins, hnRNP G, RBMY and hnRNP G-T...
  8. Soulard M, Della Valle V, Siomi M, Pinol Roma S, Codogno P, Bauvy C, et al. hnRNP G: sequence and characterization of a glycosylated RNA-binding protein. Nucleic Acids Res. 1993;21:4210-7 pubmed
    ..Here we show that p43 is an RNA-binding protein, and identify it as hnRNP G, a previously described component of heterogeneous nuclear ribonucleoprotein complexes...
  9. Tsujimura A, Fujita K, Komori K, Tanjapatkul P, Miyagawa Y, Takada S, et al. Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. Asian J Androl. 2006;8:213-8 pubmed
    ..The DNA were analyzed for RBMX by expressed sequence tag (EST) deletion and for the like sequence on chromosome 9 (RBMXL9) by microsatellite ..
  10. Shin K, Kim R, Yu B, Kang M, Elashoff D, Christensen R, et al. Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. Oral Oncol. 2011;47:1011-6 pubmed publisher
    We previously reported that wild type (wt) hnRNP G exhibited tumor suppressive activity in human oral squamous cell carcinoma (HOSCC) cell lines lacking hnRNP G...
  11. Le Coniat M, Soulard M, Della Valle V, Larsen C, Berger R. Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12. Hum Genet. 1992;88:593-5 pubmed
  12. Adamson B, Smogorzewska A, Sigoillot F, King R, Elledge S. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012;14:318-28 pubmed publisher
    ..Three candidate proteins localized to DNA lesions, including RBMX, a heterogeneous nuclear ribonucleoprotein that has a role in alternative splicing...
  13. Liu N, Zhou K, Parisien M, Dai Q, Diatchenko L, Pan T. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 2017;45:6051-6063 pubmed publisher
    ..Here, we show that m6A increases the accessibility of its surrounding RNA sequence to bind heterogeneous nuclear ribonucleoprotein G (HNRNPG)...
  14. Stoss O, Olbrich M, Hartmann A, Konig H, Memmott J, Andreadis A, et al. The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. J Biol Chem. 2001;276:8665-73 pubmed
    ..Because the related protein of rSLM-2, Sam68, is believed to play a role as an adapter protein during signal transduction, we postulate that rSLM-2 is a link between signal transduction pathways and pre-mRNA processing. ..
  15. Hirai Y, Honda T, Makino A, Watanabe Y, Tomonaga K. X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. J Gen Virol. 2015;96:3198-203 pubmed publisher
    ..In this study, we identified X-linked RNA-binding motif protein (RBMX) as a nuclear factor interacting with BDV nucleoprotein...
  16. Hofmann Y, Wirth B. hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1. Hum Mol Genet. 2002;11:2037-49 pubmed
    ..Finally, we suggest a model of how the exon 7 mRNA processing is regulated by the splicing factors identified so far. ..
  17. Venables J, Vernet C, Chew S, Elliott D, Cowmeadow R, Wu J, et al. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Hum Mol Genet. 1999;8:959-69 pubmed
    ..RBM and other hnRNP G family members are candidate downstream targets for regulation by T-STAR/ETOILE and SAM68.
  18. Lin T, Chan L, Fan Y, Lin C, Chow K, Lin S, et al. Use of a recombinant protein containing major epitopes of hnRNP G to detect anti-hnRNP G antibodies in dogs with systemic lupus erythematosus. Res Vet Sci. 2006;81:335-9 pubmed
    The objective of this study was to express major epitopes of heterogeneous nuclear ribonucleoprotein G (hnRNP G) for detecting anti-hnRNP G antibodies in dogs with systemic lupus erythematosus (SLE)...
  19. Pérez Oliva A, Lachaud C, Szyniarowski P, Muñoz I, MacArtney T, Hickson I, et al. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. EMBO J. 2015;34:326-43 pubmed publisher
    ..Together, these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair. ..
  20. Peneder P, Wallner B, Vogl C. Exchange of genetic information between therian X and Y chromosome gametologs in old evolutionary strata. Ecol Evol. 2017;7:8478-8487 pubmed publisher
    ..alignments of the coding sequences of genes from cattle, mice, and humans identified four genes, DDX3X/Y,RBMX/Y,USP9X/Y, and UTX/Y, exhibiting a preradiation topology...
  21. Angenstein F, Evans A, Settlage R, Moran S, Ling S, Klintsova A, et al. A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci. 2002;22:8827-37 pubmed
  22. Sandrock K, Bielek H, Schradi K, Schmidt G, Klugbauer N. The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. Traffic. 2010;11:198-209 pubmed publisher
    ..Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis revealed that nuclear Rac1 coimmunoprecipitates with numerous proteins. In the nucleus, Rac1 may participate in a variety of so far uncharacterized processes. ..
  23. Zhang D, Qu L, Zhou B, Wang G, Zhou G. Genomic variations in the counterpart normal controls of lung squamous cell carcinomas. Front Med. 2018;12:280-288 pubmed publisher
    ..Twenty five genes in CNCs had a variation rate that exceeded 2%, including ARSD (18.62%), MUC4 (8.79%), and RBMX (7.11%). CNC variations in CTAGE5 and USP17L7 were associated with the poor prognosis of patients with LUSC...
  24. Adamik B, Islam A, Rouhani F, Hawari F, Zhang J, Levine S. An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release. Biochem Biophys Res Commun. 2008;371:505-9 pubmed publisher
    ..Co-immunoprecipitation identified an association between ARTS-1 and RBMX (RNA-binding motif gene, X chromosome), a 43-kDa heterogeneous nuclear ribonucleoprotein...
  25. Martínez Arribas F, Agudo D, Pollan M, Gómez Esquer F, Díaz Gil G, Lucas R, et al. Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer. J Cell Biochem. 2006;97:1275-82 pubmed
    ..We measured the expression of the X-chromosome RBM genes (RBMX, RBM3, and RBM10) in 122 breast cancers by means of differential RT-PCR...
  26. Hirschfeld M, Ouyang Y, Jaeger M, Erbes T, Orlowska Volk M, zur Hausen A, et al. HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer. BMC Cancer. 2015;15:86 pubmed publisher
    ..Exon7 contains potential binding sites for the two functional splicing regulatory opponents, HNRNPG and HTRA2-BETA1 known to trigger opposite effects on EC outcome...
  27. Shashi V, Xie P, Schoch K, Goldstein D, Howard T, Berry M, et al. The RBMX gene as a candidate for the Shashi X-linked intellectual disability syndrome. Clin Genet. 2015;88:386-90 pubmed publisher
    ..with this disorder, we identified a 23 bp frameshift deletion in the RNA binding motif protein X-linked (RBMX) gene at Xq26 in the affected males (n = 7), one carrier female, absent in unaffected males (n ..
  28. Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, et al. Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005;129:1225-36 pubmed
    ..Certain mRNA splicing abbreviations seen in human cancers may be induced by the activation of the Wnt signaling pathway. ..
  29. Lu J, Xu D, Jiang Y, Kong S, Shen Z, Xia S, et al. Integrated analysis of mRNA and viral miRNAs in the kidney of Carassius auratus gibelio response to cyprinid herpesvirus 2. Sci Rep. 2017;7:13787 pubmed publisher
    ..Finally, we presented four genes involved in RIG-I-like pathways, including host gene IRF3, RBMX, PIN1, viral gene ORF4, which are negatively regulated by CyHV-2 encoded miRNA miR-C4...
  30. Venables J, Elliott D, Makarova O, Makarov E, Cooke H, Eperon I. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Hum Mol Genet. 2000;9:685-94 pubmed
    ..RBMY expresses RBM only in the nuclei of germ cells, whereas its X chromosome homologue, RBMX, expresses hnRNP G ubiquitously...
  31. Shin K, Kim R, Kim R, Kang M, Park N. hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. Biochem Biophys Res Commun. 2008;372:880-5 pubmed publisher
    ..Previously, we showed that hnRNP G has tumor-suppressive activity in human oral squamous cell carcinoma cells...