RBM8A

Summary

Gene Symbol: RBM8A
Description: RNA binding motif protein 8A
Alias: BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA-binding protein 8A, BOV-1, RNA binding motif protein 8B, RNA-binding protein Y14, binder of OVCA1-1, ribonucleoprotein RBM8, ribonucleoprotein RBM8A
Species: human
Products:     RBM8A

Top Publications

  1. Andersen C, Ballut L, Johansen J, Chamieh H, Nielsen K, Oliveira C, et al. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science. 2006;313:1968-72 pubmed
    ..adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic...
  2. Zhao X, Nowak N, Shows T, Aplan P. MAGOH interacts with a novel RNA-binding protein. Genomics. 2000;63:145-8 pubmed
    ..This gene, designated RBM8, encodes a 173-aa protein that was shown to have an apparent molecular mass of 26 kDa, as demonstrated by in vitro ..
  3. Ballut L, Marchadier B, Baguet A, Tomasetto C, Seraphin B, Le Hir H. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol. 2005;12:861-9 pubmed
    ..Here we show that recombinant EJC subunits MLN51, MAGOH and Y14, together with the DEAD-box protein eIF4AIII bound to ATP, are necessary and sufficient to form a highly stable ..
  4. Kataoka N, Diem M, Kim V, Yong J, Dreyfuss G. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J. 2001;20:6424-33 pubmed
    The RNA-binding protein Y14 binds preferentially to mRNAs produced by splicing and is a component of a multiprotein complex that assembles approximately 20 nucleotides upstream of exon-exon junctions...
  5. Hsu I, Hsu M, Li C, Chuang T, Lin R, Tarn W. Phosphorylation of Y14 modulates its interaction with proteins involved in mRNA metabolism and influences its methylation. J Biol Chem. 2005;280:34507-12 pubmed
    ..This report is the first to identify potential post-translational modifications of the EJC core component Y14. We demonstrate that Y14 is phosphorylated at its repeated arginine/serine (RS) dipeptides, likely by SR protein-..
  6. Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, et al. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev. 2006;20:355-67 pubmed
    ..Here we show that SMG-1 binds to the mRNA-associated components of the EJC, Upf2, Upf3b, eIF4A3, Magoh, and Y14. Further, we describe a novel complex that contains the NMD factors SMG-1 and Upf1, and the translation termination ..
  7. Chuang T, Peng P, Tarn W. The exon junction complex component Y14 modulates the activity of the methylosome in biogenesis of spliceosomal small nuclear ribonucleoproteins. J Biol Chem. 2011;286:8722-8 pubmed publisher
    The RNA-binding protein Y14 heterodimerizes with Mago as the core of the exon junction complex during precursor mRNA splicing and plays a role in mRNA surveillance in the cytoplasm...
  8. Gehring N, Neu Yilik G, Schell T, Hentze M, Kulozik A. Y14 and hUpf3b form an NMD-activating complex. Mol Cell. 2003;11:939-49 pubmed
    ..Here, we identify a conserved domain of hUpf3b that mediates an interaction with the EJC protein Y14. Tethered function analysis shows that the Y14/hUpf3b interaction is essential for NMD, while surprisingly the ..
  9. Lykke Andersen J, Shu M, Steitz J. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 2001;293:1836-9 pubmed
    ..Significantly, RNPS1 triggers NMD when tethered to the 3' untranslated region of beta-globin mRNA, demonstrating its role as a subunit of the postsplicing complex directly involved in mRNA surveillance...

More Information

Publications96

  1. Salicioni A, Xi M, Vanderveer L, Balsara B, Testa J, Dunbrack R, et al. Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. Genomics. 2000;69:54-62 pubmed
    ..8-kb transcript resides at chromosome 5q13-q14 (HGMW-approved gene symbol RBM8B)...
  2. Fribourg S, Gatfield D, Izaurralde E, Conti E. A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol. 2003;10:433-9 pubmed
    b>Y14 and Mago are conserved eukaryotic proteins that associate with spliced mRNAs in the nucleus and remain associated at exon junctions during and after nuclear export...
  3. Kataoka N, Yong J, Kim V, Velazquez F, Perkinson R, Wang F, et al. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell. 2000;6:673-82 pubmed
    We describe a novel RNA binding protein, Y14, a predominantly nuclear nucleocytoplasmic shuttling protein...
  4. Lau C, Diem M, Dreyfuss G, Van Duyne G. Structure of the Y14-Magoh core of the exon junction complex. Curr Biol. 2003;13:933-41 pubmed
    ..The proteins of the EJC, Y14, Magoh, Aly/REF, RNPS1, Srm160, and Upf3, play critical roles in postsplicing processing, including nuclear export ..
  5. Hachet O, Ephrussi A. Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Curr Biol. 2001;11:1666-74 pubmed
    ..It was recently shown that human Y14, a nuclear protein that associates with mRNAs upon splicing and shuttles to the cytoplasm, interacts with MAGOH, ..
  6. Franks T, Singh G, Lykke Andersen J. Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell. 2010;143:938-50 pubmed publisher
    ..This uncovers a previously unappreciated and potentially regulated step in mRNA decay and raises the question of how other mRNA decay pathways release protein components of substrate mRNPs...
  7. Mingot J, Kostka S, Kraft R, Hartmann E, Gorlich D. Importin 13: a novel mediator of nuclear import and export. EMBO J. 2001;20:3685-94 pubmed
    ..It accounts for nuclear accumulation of the SUMO-1/sentrin-conjugating enzyme hUBC9 and mediates import of the RBM8 (Y14) protein, and is therefore referred to as importin 13 (Imp13)...
  8. Le Hir H, Izaurralde E, Maquat L, Moore M. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 2000;19:6860-9 pubmed
    ..of the complex are the splicing-associated factors SRm160, DEK and RNPS1, the mRNA-associated shuttling protein Y14 and the mRNA export factor REF...
  9. Gehring N, Kunz J, Neu Yilik G, Breit S, Viegas M, Hentze M, et al. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell. 2005;20:65-75 pubmed
    ..Specifically, Y14, MAGOH, and eIF4A3 can activate NMD in an UPF2-independent manner, whereas RNPS1-induced NMD requires UPF2...
  10. Kataoka N, Dreyfuss G. A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. J Biol Chem. 2004;279:7009-13 pubmed
    ..In contrast, Y14 and magoh, which remain stably associated with mRNA after export to the cytoplasm, join the EJC during or after ..
  11. Kim V, Kataoka N, Dreyfuss G. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science. 2001;293:1832-6 pubmed
    ..We found that hUpf3 interacts with Y14, a component of post-splicing mRNA-protein (mRNP) complexes, and that hUpf3 is enriched in Y14-containing mRNP ..
  12. Fink H, Langsetmo L, Vo T, Orwoll E, Schousboe J, Ensrud K. Association of High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) bone microarchitectural parameters with previous clinical fracture in older men: The Osteoporotic Fractures in Men (MrOS) study. Bone. 2018;113:49-56 pubmed publisher
    ..of distal radius, proximal (diaphyseal) tibia and distal tibia HR-pQCT parameters measured at the Year 14 (Y14) study visit with prior clinical fracture...
  13. Ma Q, Tatsuno T, Nakamura Y, Ishigaki Y. The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization. Biochem Biophys Res Commun. 2019;: pubmed publisher
    Reduced expression of the Y14 gene is a cause of Thrombocytopenia-absent radius (TAR) syndrome...
  14. Chuang T, Lee K, Tarn W. Function and pathological implications of exon junction complex factor Y14. Biomolecules. 2015;5:343-55 pubmed publisher
    ..The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement...
  15. Ramage H, Kumar G, Verschueren E, Johnson J, Von Dollen J, Johnson T, et al. A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell. 2015;57:329-340 pubmed publisher
    ..Expression of core prevents WIBG from binding its regular interaction partners Y14 and Magoh, two known mediators of the nonsense-mediated mRNA decay pathway...
  16. Boisramé A, Devillers H, Onesime D, Brunel F, Pouch J, Piot M, et al. Exon junction complex components Y14 and Mago still play a role in budding yeast. Sci Rep. 2019;9:849 pubmed publisher
    ..We report the identification of the core EJC components, Mago, Y14, and eIF4A3, in at least seven Saccharomycotina species, including Yarrowia lipolytica...
  17. Ishigaki Y, Nakamura Y, Tatsuno T, Ma S, Tomosugi N. Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh. Exp Biol Med (Maywood). 2015;240:438-45 pubmed publisher
    The RNA-binding protein 8A (RBM8A)-mago-nashi homolog, proliferation-associated (Magoh) complex is a component of the exon junction complex (EJC) required for mRNA metabolism involving nonsense-mediated mRNA decay (NMD)...
  18. Cougot N, Daguenet E, Baguet A, Cavalier A, Thomas D, Bellaud P, et al. Overexpression of MLN51 triggers P-body disassembly and formation of a new type of RNA granules. J Cell Sci. 2014;127:4692-701 pubmed publisher
    ..Unlike the three other EJC core components [eIF4AIII, Magoh and Y14 (also known as RBM8A)], MLN51 is mainly located in the cytoplasm, where it plays a key role in the assembly of stress granules...
  19. Park R, Miller G. Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA. J Virol. 2018;92: pubmed publisher
    ..splicing factors, SC35 and SON, were dispersed from interchromatin granule clusters, and three mRNA export factors, Y14, ALY, and NXF1, were depleted from the nucleus...
  20. Swindell W, Sarkar M, Stuart P, Voorhees J, Elder J, Johnston A, et al. Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites. Clin Transl Med. 2015;4:13 pubmed publisher
    ..of DEGs that encode proteins interacting with PRE motifs, including TFs (GATA3, EHF, FOXM1, SOX5) and uDBPs (AVEN, RBM8A, GPAM, WISP2)...
  21. Zeng Y, Zheng H, Shen Y, Xu J, Tan M, Liu F, et al. Identification and analysis of binding residues in the CBM68 of pullulanase PulA from Anoxybacillus sp. LM18-11. J Biosci Bioeng. 2019;127:8-15 pubmed publisher
    ..Then, four key substrate binding amino acid residues (Y14, V91, G92, and R96) were obtained by alanine substitutions in this work...
  22. Gauvin T, Han B, Sun M, Griffin E. PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo. G3 (Bethesda). 2018;8:3791-3801 pubmed publisher
    ..Through an RNAi screen, we identified Y14 and MAG-1 (Drosophila tsunagi and mago nashi) as regulators of embryonic PIE-1::GFP levels...
  23. Contreras J, Begley V, Marsella L, Villalobo E. The splicing of tiny introns of Paramecium is controlled by MAGO. Gene. 2018;663:101-109 pubmed publisher
    ..The exon junction complex (EJC) is a key element of the splicing machinery. The EJC core is composed of eIF4A3, MAGO, Y14 and MLN51. Few accessory proteins, such as CWC22 or UPF3, bind transiently to the EJC...
  24. Jung W, Sierecki E, Bastiani M, O Carroll A, Alexandrov K, Rae J, et al. Cell-free formation and interactome analysis of caveolae. J Cell Biol. 2018;217:2141-2165 pubmed publisher
    ..negligible, but a small number of proteins, including TRAF2, interacted with CAV1 in a phosphorylation-(CAV1Y14)-stimulated manner...
  25. Van Krieken R, Krepinsky J. Caveolin-1 in the Pathogenesis of Diabetic Nephropathy: Potential Therapeutic Target?. Curr Diab Rep. 2017;17:19 pubmed publisher
    ..Phosphorylation of cav-1 on Y14 is an important regulator of these responses...
  26. Zhong R, Xiao J, Yu Z, Zhou J, Dai C. [Research on the effect of protection against ventilator-induced lung injury via regulation of caveolin-1/heme oxygenase-1 signaling]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:568-73 pubmed publisher
    To determine whether the inhibition of caveolin-1 tyrosine residues 14 (Cav-1-Y14) phosphorylation with protein tyrosine kinase inhibitors (PP2) will upregulate heme oxygenase-1 (HO-1) activity to protect against ventilation induced lung ..
  27. Tatsuno T, Ishigaki Y. C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization. Sci Rep. 2018;8:612 pubmed publisher
    Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC)...
  28. Zhang Y, Sachs M. Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3'UTR Introns. Genetics. 2015;200:1133-48 pubmed publisher
    ..The transcripts for EJC components eIF4A3 and Y14, and translation termination factor eRF1, contain spliced 3'-UTR introns and each was stabilized in NMD, EJC, and ..
  29. Narcís J, Tapia O, Tarabal O, Piedrafita L, Caldero J, Berciano M, et al. Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMN?7 mouse model of SMA. Sci Rep. 2018;8:9646 pubmed publisher
    ..However, these granules lacked other RNA-binding proteins, such as TDP43, PABPN1, hnRNPA12B, REF and Y14, which are essential for mRNA processing and nuclear export...
  30. Fukumura K, Wakabayashi S, Kataoka N, Sakamoto H, Suzuki Y, Nakai K, et al. The Exon Junction Complex Controls the Efficient and Faithful Splicing of a Subset of Transcripts Involved in Mitotic Cell-Cycle Progression. Int J Mol Sci. 2016;17: pubmed publisher
    ..Using HeLa cells, we depleted one of the EJC core components, Y14, and the resulting transcriptome was analyzed by deep sequencing (RNA-Seq) and confirmed by RT-PCR...
  31. Viswanathan S, Nogueira M, Buss C, Krill Burger J, Wawer M, Malolepsza E, et al. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018;50:937-943 pubmed publisher
    ..Dependency on IPO13, an importin-β receptor that mediates nuclear import of the MAGOH/B-Y14 heterodimer9, is highly correlated with dependency on both MAGOH and MAGOHB...
  32. Lu C, Lee C, Tseng C, Tarn W. Y14 governs p53 expression and modulates DNA damage sensitivity. Sci Rep. 2017;7:45558 pubmed publisher
    b>Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and apoptosis...
  33. Rey Barroso J, Alvarez Barrientos A, Rico Leo E, Contador Troca M, Carvajal Gonzalez J, Echarri A, et al. The Dioxin receptor modulates Caveolin-1 mobilization during directional migration: role of cholesterol. Cell Commun Signal. 2014;12:57 pubmed publisher
    ..since its upregulation reduced Cav-1 in DRMs in both AhR+/+ and AhR-/-cells, despite the lower basal levels of Y14-Cav-1 in the null cells...
  34. Mao H, Brown H, Silver D. Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. RNA. 2017;23:23-31 pubmed
    ..Biochemistry and genetic studies have concluded that the EJC is composed of four core proteins, MAGOH, EIF4A3, RBM8A, and CASC3...
  35. Zhang Y, Shen B, Zhang D, Wang Y, Tang Z, Ni N, et al. miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a. Oncotarget. 2017;8:31993-32008 pubmed publisher
    ..study demonstrated that microRNA (miR)-29a modulated the proliferation and differentiation of RPCs by suppressing RBM8A (one of the factors in the exon junction complex)...
  36. Sofos N, Winkler M, Brodersen D. RRM domain of human RBM7: purification, crystallization and structure determination. Acta Crystallogr F Struct Biol Commun. 2016;72:397-402 pubmed publisher
    ..Molecular replacement using a previously determined solution structure of RBM7 was unsuccessful. Instead, RBM8 and CBP20 RRM-domain crystal structures were used to successfully determine the RBM7 structure by molecular ..
  37. Marayati B, Hoskins V, Boger R, Tucker J, Fishman E, Bray A, et al. The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis. RNA. 2016;22:1349-59 pubmed publisher
    ..factor eIF4aIII in the fission yeast Schizosaccharomyces pombe In mammals, together with MAGO (Mnh1), Rnps1, and Y14, elF4AIII (pFal1) forms the core of the exon junction complex (EJC), which is essential for transcriptional ..
  38. Huang C, Zhang Z, Chen L, Lee H, Ayrapetov M, Zhao T, et al. Acetylation within the N- and C-Terminal Domains of Src Regulates Distinct Roles of STAT3-Mediated Tumorigenesis. Cancer Res. 2018;78:2825-2838 pubmed publisher
    ..N-terminal domain phosphorylation (Y14, Y45, and Y68) of STAT3 by c-Src activates transcriptionally active dimers of STAT3...
  39. Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y. Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep. 2016;14:655-60 pubmed publisher
    ..The immunopurified fractions containing nuclear and cytoplasmic Upf2 also contained one of the EJC core factors, RBM8A. These results implied the existence of Upf2 in the nucleoplasm and the cytoplasm, and it appeared to be involved ..
  40. Mao H, McMahon J, Tsai Y, Wang Z, Silver D. Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016;12:e1006282 pubmed publisher
    The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies...
  41. Huang C, Sie Y, Chen Y, Huang T, Lu C. Two highly similar DEAD box proteins, OsRH2 and OsRH34, homologous to eukaryotic initiation factor 4AIII, play roles of the exon junction complex in regulating growth and development in rice. BMC Plant Biol. 2016;16:84 pubmed publisher
    ..EJC), which contains four core components, eukaryotic initiation factor 4AIII (eIF4AIII), MAGO/NASHI (MAGO), Y14/Tsunagi/RNA-binding protein 8A, and Barentsz/Metastatic lymph node 51, is formed in both nucleus and cytoplasm, and ..
  42. Ensrud K, Vo T, Burghardt A, Schousboe J, Cauley J, Taylor B, et al. Weight loss in men in late life and bone strength and microarchitecture: a prospective study. Osteoporos Int. 2018;29:1549-1558 pubmed publisher
    ..Weight change from Y7 to Y14 exams (mean 7...
  43. Ortiz R, Diaz J, Diaz N, Lobos González L, Cárdenas A, Contreras P, et al. Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Oncotarget. 2016;7:40571-40593 pubmed publisher
    ..We recently implicated CAV1 phosphorylation on tyrosine 14 (Y14) in CAV1-enhanced cell migration...
  44. Cilano K, Mazanek Z, Khan M, Metcalfe S, Zhang X. A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana. PLoS ONE. 2016;11:e0148200 pubmed publisher
    ..Four proteins, MAGO, Y14, eIF4AIII and BTZ, function as core components of the EJC...
  45. Varela Chavez C, Haustant G, Baron B, England P, Chenal A, Pauillac S, et al. The Tip of the Four N-Terminal ?-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation. Toxins (Basel). 2016;8:90 pubmed publisher
    ..Residues Y14, V15, F17, and R18 on loop 1, between helices 1 and 2, in coordination with R68 from loop 3, between helices 3 and ..
  46. Brès V, Tagami H, Peloponese J, Loret E, Jeang K, Nakatani Y, et al. Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. EMBO J. 2002;21:6811-9 pubmed
    ..is an atypical transcriptional activator that functions through binding, not to DNA, but to a short leader RNA, TAR. Although details of its functional mechanism are still unknown, emerging findings suggest that Tat serves ..
  47. Tewes A, Rall K, Römer T, Hucke J, Kapczuk K, Brucker S, et al. Variations in RBM8A and TBX6 are associated with disorders of the müllerian ducts. Fertil Steril. 2015;103:1313-8 pubmed publisher
    ..The control group was composed of 94 fertile women with at least one child. Sequential analysis of RBM8A and TBX6 in a group of 167 clinically well-defined patients with disorders of the müllerian ducts...
  48. Hu J, Li Y, Li P. MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. PLoS ONE. 2013;8:e68291 pubmed publisher
    ..translation, and we identify MARVELD1 as an important component of the molecular machinery containing UPF1 and Y14. Furthermore, we determined the specific regions of MARVELD1 and UPF1 responsible for their interaction...
  49. Diem M, Chan C, Younis I, Dreyfuss G. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Nat Struct Mol Biol. 2007;14:1173-9 pubmed
    ..The EJC proteins Y14 and magoh remain bound to spliced mRNAs after their export from the nucleus to the cytoplasm and are removed only ..
  50. Muromoto R, Taira N, Ikeda O, Shiga K, Kamitani S, Togi S, et al. The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation. Biochem Biophys Res Commun. 2009;382:63-8 pubmed publisher
    ..In a previous study, we found that Y14, a core component of the exon-junction complex (EJC) bound to STAT3 and upregulated the transcriptional activity of ..
  51. Zou D, McSweeney C, Sebastian A, Reynolds D, Dong F, Zhou Y, et al. A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors. Neural Dev. 2015;10:18 pubmed publisher
    ..This mechanism depends on several core factors in the exon junction complex (EJC), eIF4A3, RBM8a, Magoh, and BTZ, as well as peripheral factors to distinguish premature stop codons (PTCs) from normal stop codons ..
  52. Lejeune F, Ishigaki Y, Li X, Maquat L. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 2002;21:3536-45 pubmed
    ..Consistent with this evidence, we demonstrate that RNPS1, Y14, SRm160, REF/Aly, TAP, Upf3X and Upf2 are detected in the nuclear fraction on CBP80-bound but not eIF4E-bound mRNA...
  53. Togi S, Shiga K, Muromoto R, Kato M, Souma Y, Sekine Y, et al. Y14 positively regulates TNF-?-induced NF-?B transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein. J Immunol. 2013;191:1436-44 pubmed publisher
    Although Y14 is known to be a component of the exon junction complex, we previously reported that Y14 regulates IL-6-induced STAT3 activation...
  54. Liang R, Lin Y, Ye J, Yan X, Liu Z, Li Y, et al. High expression of RBM8A predicts poor patient prognosis and promotes tumor progression in hepatocellular carcinoma. Oncol Rep. 2017;37:2167-2176 pubmed publisher
    ..motif (RBM) proteins are closely related to various cancers, the clinical importance and underlying mechanisms of RBM8A in HCC remain elusive...
  55. Wilson K, Fortes P, Singh U, Ohno M, Mattaj I, Cerione R. The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. J Biol Chem. 1999;274:4166-73 pubmed
    ..Taken together, these data identify the CBC as a nuclear target for growth factor-coupled signal transduction and suggest novel mechanisms by which growth factors can influence gene expression and cell growth. ..
  56. Conklin D, Rixon M, Kuestner R, Maurer M, Whitmore T, Millar R. Cloning and gene expression of a novel human ribonucleoprotein. Biochim Biophys Acta. 2000;1492:465-9 pubmed
    This paper reports on the cloning and characterization of a novel human ribonucleoprotein, RBM8, containing a single RNA binding domain comprising the two RNP-CS and RNP-2 consensus motifs. The protein has 55% identity to a segment of a C...
  57. Shinde M, Sidoli S, Kulej K, Mallory M, Radens C, Reicherter A, et al. Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing. J Biol Chem. 2017;292:18240-18255 pubmed publisher
    ..i>Gsk3 DKO reduced phosphorylation of the splicing factors RBM8A, SRSF9, and PSF as well as the nucleolar proteins NPM1 and PHF6, and recombinant GSK-3β phosphorylated these ..
  58. McCracken S, Longman D, Johnstone I, Caceres J, Blencowe B. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. J Biol Chem. 2003;278:44153-60 pubmed
    ..The EJC components RNPS1, REF, UAP56, and Y14 interact with SRm160...
  59. Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009;23:1091-105 pubmed publisher
  60. Ohbayashi N, Taira N, Kawakami S, Togi S, Sato N, Ikeda O, et al. An RNA biding protein, Y14 interacts with and modulates STAT3 activation. Biochem Biophys Res Commun. 2008;372:475-9 pubmed publisher
    ..We identified Y14, an RNA-binding protein, as a novel STAT3 binding partner...
  61. Mao H, Pilaz L, McMahon J, Golzio C, Wu D, Shi L, et al. Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. J Neurosci. 2015;35:7003-18 pubmed publisher
    ..1 genes in neurogenesis has remained elusive. Here, we show that haploinsufficiency for Rbm8a, an exon junction complex (EJC) component within 1q21...
  62. Chan C, Dostie J, Diem M, Feng W, Mann M, Rappsilber J, et al. eIF4A3 is a novel component of the exon junction complex. RNA. 2004;10:200-9 pubmed
    ..We show that eIF4A3 associates preferentially with nuclear complexes containing the EJC proteins magoh and Y14. Furthermore, eIF4A3, but not the highly related eIF4A1 or eIF4A2, preferentially associates with spliced mRNA...
  63. Chuang T, Chang W, Lee K, Tarn W. The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation. Mol Biol Cell. 2013;24:1-13 pubmed publisher
    ..Here we show that an EJC core heterodimer, Y14/Magoh, specifically associates with mRNA-degradation factors, including the mRNA-decapping complex and ..
  64. Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas A, et al. SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev. 2010;24:2440-50 pubmed publisher
  65. Kiselev A, Stepanova I, Adonin L, Batalova F, Parfenov V, Bogolyubov D, et al. The exon junction complex factor Y14 is dynamic in the nucleus of the beetle Tribolium castaneum during late oogenesis. Mol Cytogenet. 2017;10:41 pubmed publisher
    ..factors, including the components of the exon junction complex with its core component, the splicing factor Y14. We employed a gene engineering approach with injection of mRNA derived from the Myc-tagged Y14 plasmid-based ..
  66. Faurholm B, Millar R, Katz A. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. Genomics. 2001;78:15-8 pubmed
    ..loci encoding the human type II gonadotropin-releasing hormone (GnRH) receptor and RNA-binding motif protein-8 (RBM8A). In both loci the genes overlap and are in antisense orientation to each other...
  67. Kunz J, Neu Yilik G, Hentze M, Kulozik A, Gehring N. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA. 2006;12:1015-22 pubmed
    ..We show that induction of NMD by hUpf3 proteins requires interaction with Y14, Magoh, BTZ, and eIF4AIII...
  68. Meng F, Saxena S, Liu Y, Joshi B, Wong T, Shankar J, et al. The phospho-caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration. Mol Biol Cell. 2017;28:2190-2201 pubmed publisher
    Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82-101)...
  69. Chuang T, Lee K, Lou Y, Lu C, Tarn W. A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement. J Biol Chem. 2016;291:8565-74 pubmed publisher
    ..The exon junction complex core protein Y14 is required for nonsense-mediated mRNA decay (NMD) and promotes translation...
  70. Sato H, Hosoda N, Maquat L. Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell. 2008;29:255-62 pubmed publisher
    ..Increased TAP binding correlates with increased SF2/ASF binding, but not increased REF/Aly or Y14 binding...
  71. Gong P, Zhao M, He C. Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode. PLoS ONE. 2014;9:e84842 pubmed publisher
    ..MAGO (short form of MAGO NASHI) and Y14 (also Tsunagi or RBM8) are the EJC core components...
  72. Gehring N, Lamprinaki S, Kulozik A, Hentze M. Disassembly of exon junction complexes by PYM. Cell. 2009;137:536-48 pubmed publisher
    ..This disassembly involves PYM binding to the EJC proteins MAGOH-Y14. PYM overexpression in cells disrupts EJC association with spliced mRNA and inhibits nonsense-mediated mRNA decay...
  73. Gandhi T, Zhong J, Mathivanan S, Karthick L, Chandrika K, Mohan S, et al. Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet. 2006;38:285-93 pubmed
    ..The human interaction map constructed from our analysis should facilitate an integrative systems biology approach to elucidating the cellular networks that contribute to health and disease states. ..
  74. Manukjan G, Bösing H, Schmugge M, Strauß G, Schulze H. Impact of genetic variants on haematopoiesis in patients with thrombocytopenia absent radii (TAR) syndrome. Br J Haematol. 2017;179:606-617 pubmed publisher
    ..genetics of TAR syndrome has recently been resolved and comprises a microdeletion on Chromosome 1 including the RBM8A gene and a single nucleotide polymorphism (SNP) either at the 5' untranslated region (5'UTR) or within the first ..
  75. Mei H, Mack D, Galan A, Halim N, Heldsinger A, Loo J, et al. Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription. Bioorg Med Chem. 1997;5:1173-84 pubmed
    ..program begins with a search for small organic molecules that would interfere with the binding of Tat protein to TAR RNA...
  76. Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, et al. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Mol Cell Biol. 2012;32:954-67 pubmed publisher
    ..Depleting proteins known as core (Y14 and eIF4A3) or auxiliary (RNPS1, Acinus, and SAP18) components of the exon junction complex (EJC) improved the ..
  77. Chamieh H, Ballut L, Bonneau F, Le Hir H. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol. 2008;15:85-93 pubmed
    ..The EJC proteins MAGOH, Y14 and eIF4AIII provide a composite binding site for UPF3b that serves as a bridge to UPF2 and UPF1...
  78. Albers C, Paul D, Schulze H, Freson K, Stephens J, Smethurst P, et al. Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet. 2012;44:435-9, S1-2 pubmed publisher
    ..Compound inheritance of a rare null allele and one of two low-frequency SNPs in the regulatory regions of RBM8A, encoding the Y14 subunit of EJC, causes TAR...
  79. Okubo K, Mitani H, Naruse K, Kondo M, Shima A, Tanaka M, et al. Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes. Biochem Biophys Res Commun. 2002;293:327-31 pubmed
    ..To elucidate the mechanism through which such multiple human GnRH-RII/RBM8 loci arose, here we have defined an RBM8 locus in a comparative model species, the medaka Oryzias latipes...
  80. You K, Li L, Kim N, Kang H, Koh K, Chwae Y, et al. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 2007;5:e109 pubmed
    ..Our findings suggest a novel mechanism of gene expression regulation for PTC-containing mRNAs in which the deleterious transcripts are regulated either by NMD or translational repression. ..
  81. Choudhury S, Singh A, McLeod T, Blanchette M, Jang B, Badenhorst P, et al. Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster. elife. 2016;5: pubmed publisher
    ..its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophila ..
  82. Garcia Garcia E, Little J, Kalderon D. The Exon Junction Complex and Srp54 Contribute to Hedgehog Signaling via ci RNA Splicing in Drosophila melanogaster. Genetics. 2017;206:2053-2068 pubmed publisher
    ..Here, we identified Mago Nashi (Mago) and Y14 core Exon Junction Complex (EJC) proteins, as well as the Srp54 splicing factor, as modifiers of Hh pathway ..
  83. Kataoka N, Diem M, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, et al. Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Sci Rep. 2011;1:92 pubmed publisher
    ..The core of EJC consists of four proteins, eIF4AIII, MLN51, Y14 and Magoh...
  84. Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, et al. Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells. Exp Biol Med (Maywood). 2013;238:889-97 pubmed publisher
    b>RBM8A (Y14) contains an RNA-binding motif and forms a tight heterodimer with Magoh...
  85. Barbosa I, Haque N, Fiorini F, Barrandon C, Tomasetto C, Blanchette M, et al. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Nat Struct Mol Biol. 2012;19:983-90 pubmed publisher
    ..We elucidated the initial step of EJC assembly and the duality of CWC22 function that hinders eIF4AIII from nonspecifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. ..
  86. McMahon J, Miller E, Silver D. The exon junction complex in neural development and neurodevelopmental disease. Int J Dev Neurosci. 2016;55:117-123 pubmed publisher
    ..The EJC is an RNA binding complex composed of 3 core proteins, EIF4A3 (DDX48), RBM8A (Y14), and MAGOH, and is a major hub of post-transcriptional regulation...