RBM4

Summary

Gene Symbol: RBM4
Description: RNA binding motif protein 4
Alias: LARK, RBM4A, ZCCHC21, ZCRB3A, RNA-binding protein 4, RNA-binding motif protein 4a, lark homolog, transcriptional coactivator CoAZ, zinc finger CCHC-type and RNA binding motif 3A
Species: human
Products:     RBM4

Top Publications

  1. Lai M, Kuo H, Chang W, Tarn W. A novel splicing regulator shares a nuclear import pathway with SR proteins. EMBO J. 2003;22:1359-69 pubmed
    ..Here we identify and characterize a non-SR protein, RNA-binding motif protein 4 (RBM4), as a novel substrate of TRN-SR2. TRN-SR2 interacts specifically with RBM4 in a Ran-sensitive manner...
  2. Lin J, Hsu M, Tarn W. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Proc Natl Acad Sci U S A. 2007;104:2235-40 pubmed
    RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA...
  3. Lu C, Chen T, Wu J, Chen H, Yu H, Tarn W. Phylogenetic and molecular characterization of the splicing factor RBM4. PLoS ONE. 2013;8:e59092 pubmed publisher
    The mammalian multi-functional RNA-binding motif 4 (RBM4) protein regulates alterative splicing of precursor mRNAs and thereby affects pancreas and muscle cell differentiation. RBM4 homologs exist in all metazoan lineages...
  4. Lin J, Tarn W. RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. J Cell Biol. 2011;193:509-20 pubmed publisher
    ..We previously reported that the RNA-binding protein RBM4 antagonizes the activity of splicing factor PTB to modulate muscle cell-specific exon selection of ?-tropomyosin...
  5. Kar A, Havlioglu N, Tarn W, Wu J. RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion. J Biol Chem. 2006;281:24479-88 pubmed
    ..Using this expression cloning approach, we have identified a previously unknown tau exon 10 splicing regulator, RBM4 (RNA binding motif protein 4)...
  6. Markus M, Morris B. Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties. DNA Cell Biol. 2006;25:457-64 pubmed
    ..function of human Lark we uncovered a frame-shift error in the published sequence to reveal that Lark is, in fact, RBM4, a recently described splicing regulator...
  7. Brooks Y, Wang G, Yang Z, Smith K, Bieberich E, Ko L. Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation. J Biol Chem. 2009;284:18033-46 pubmed publisher
    ..analysis showed that mammalian CoAA and RBM4 genes share common ancestry with the Drosophila melanogaster gene Lark, which is known to regulate early development and circadian rhythms...
  8. El Gazzar M, Church A, Liu T, McCall C. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-? during TLR4-induced gene reprogramming. J Leukoc Biol. 2011;90:509-19 pubmed publisher
    ..translation repressor complex of TNF-? by preventing the interaction of the RNA-binding protein effector Ago2 and RBM4. We also determined that once endotoxin tolerance is established, and specific genes have been reprogrammed, ..
  9. Lin J, Tarn W. Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol Cell Biol. 2005;25:10111-21 pubmed
    RNA-binding motif protein 4 (RBM4) has been implicated in the regulation of precursor mRNA splicing. Using differential display analysis, we identified mRNAs that associate with RBM4-containing messenger RNPs in vivo...

More Information

Publications71

  1. Lin J, Tarn W. RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation. J Biol Chem. 2009;284:34658-65 pubmed publisher
    The RNA-binding motif protein 4 (RBM4) plays multiple roles in mRNA metabolism, including translation control. RBM4 suppresses cap-dependent translation but activates internal ribosome entry site-mediated translation...
  2. Markus M, Morris B. RBM4: a multifunctional RNA-binding protein. Int J Biochem Cell Biol. 2009;41:740-3 pubmed publisher
    RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells...
  3. Kemp R, McKechnie A. Thermal physiology of a range-restricted desert lark. J Comp Physiol B. 2019;189:131-141 pubmed publisher
    ..We tested the prediction that the threatened red lark (Calendulauda burra), a species restricted to very arid parts of South Africa and which is not known to drink, ..
  4. Laiolo P, Obeso J, Roggia Y. Mimicry as a novel pathway linking biodiversity functions and individual behavioural performances. Proc Biol Sci. 2011;278:1072-81 pubmed publisher
    ..We studied the songs of two lark species (genus Galerida) that increase the complexity of their song displays by mimicking other birds, and analysed ..
  5. Ranjbar Jafarabadi A, Riyahi Bakhtiari A, Spanò N, Cappello T. First report of geochemical fractionation distribution, bioavailability and risk assessment of potentially toxic inorganic elements in sediments of coral reef Islands of the Persian Gulf, Iran. Mar Pollut Bull. 2018;137:185-197 pubmed publisher
    ..Based on modified risk assessment analysis, the sediments from Kharg, Lavan, Siri and Lark Islands showed medium adverse effects...
  6. Chi Y, Lin J. RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism. Biochim Biophys Acta Mol Cell Res. 2018;1865:1515-1525 pubmed publisher
    ..Moreover, discriminative splicing patterns of PRDM16 transcripts were noted in embryonic and postnatal RBM4a-/- BATs...
  7. Facer Childs E, Boiling S, Balanos G. The effects of time of day and chronotype on cognitive and physical performance in healthy volunteers. Sports Med Open. 2018;4:47 pubmed publisher
    Whether you are a morning lark or a night owl has proven to be a key contributor in the timing of peak athletic performance...
  8. Huang Y, McNeil G, Jackson F. Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation. PLoS Genet. 2014;10:e1004536 pubmed publisher
    ..we show that translation of dbt transcripts are directly regulated by a rhythmic RNA-binding protein (RBP) called LARK (known as RBM4 in mammals)...
  9. Ranjbar Jafarabadi A, Riyahi Bakhtiari A, Maisano M, Pereira P, Cappello T. First record of bioaccumulation and bioconcentration of metals in Scleractinian corals and their algal symbionts from Kharg and Lark coral reefs (Persian Gulf, Iran). Sci Total Environ. 2018;640-641:1500-1511 pubmed publisher
    ..seawater samples, Scleractinian corals (tissue and skeleton) and their algal symbionts collected from Kharg and Lark coral reefs in the Persian Gulf, Iran...
  10. Peng H, Liang Y, Tan T, Chuang H, Lin Y, Lin J. RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. Int J Mol Sci. 2018;19: pubmed publisher
    ..of MAP4K4 or SRSF3 were noted as well in brown adipocytes (BAs) with RNA-binding motif protein 4-knockout (RBM4-/-) compared to the wild-type counterparts...
  11. Horrocks N, Hegemann A, Ostrowski S, Ndithia H, Shobrak M, Williams J, et al. Environmental proxies of antigen exposure explain variation in immune investment better than indices of pace of life. Oecologia. 2015;177:281-90 pubmed publisher
    ..we investigated how variation in pace of life and antigen exposure influence immune investment in related lark species (Alaudidae) with differing life histories and predicted risks of exposure to environmental microbes and ..
  12. Ranjbar Jafarabadi A, Riyahi Bakhtiari A, Hédouin L, Shadmehri Toosi A, Cappello T. Spatio-temporal variability, distribution and sources of n-alkanes and polycyclic aromatic hydrocarbons in reef surface sediments of Kharg and Lark coral reefs, Persian Gulf, Iran. Ecotoxicol Environ Saf. 2018;163:307-322 pubmed publisher
    ..to assess the pollution status in the Persian Gulf, Iran, herein surface sediments were collected from Kharg and Lark coral reefs, in summer (dry season) and winter (wet season), to evaluate the spatio-temporal variations of n-..
  13. Lin J. RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes. RNA Biol. 2015;12:208-20 pubmed publisher
    ..During the differentiation of brown adipocytes, upregulated RBM4 enhanced skipping of the MEF2Cγ region which functions as a transcriptional repressor...
  14. Graham M. The voices of Iris: Cinematic representations of the aged woman and Alzheimer's disease in Iris (2001). Dementia (London). 2016;15:1171-83 pubmed publisher
    ..Further, Iris' recurrent unaccompanied song, "The Lark in the Clear Air," compels audiences to "see" Iris with their ears more than with their eyes, exemplifying the ..
  15. Qi Y, Yu J, Han W, Fan X, Qian H, Wei H, et al. A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation. Nat Commun. 2016;7:ncomms11840 pubmed publisher
    ..factor that mediates Hippo-YAP signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4, producing a truncated isoform, TEAD4-S, which lacks an N-terminal DNA-binding domain, but maintains YAP ..
  16. McClure C, Brudecki L, Yao Z, McCall C, El Gazzar M. Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages. J Innate Immun. 2015;7:572-83 pubmed publisher
    ..chromatin modifications, a translational repressor complex of Argonaute 2 (Ago2) and RNA-binding motif protein 4 (RBM4), which bind the 3'-UTR of TNFα and IL-6 mRNA, limits protein synthesis...
  17. Gowen B, Chim B, Marceau C, Greene T, Burr P, Gonzalez J, et al. A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. elife. 2015;4: pubmed publisher
    ..that the transcription factor ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA...
  18. Galewski T, Devictor V. When Common Birds Became Rare: Historical Records Shed Light on Long-Term Responses of Bird Communities to Global Change in the Largest Wetland of France. PLoS ONE. 2016;11:e0165542 pubmed publisher
    ..g. Southern Grey Shrike, Greater Short-toed Lark)...
  19. Lin J, Lu Y, Liu Y, Lin Y. RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Sci Rep. 2016;6:20665 pubmed publisher
    RNA-binding motif protein 4a (RBM4a) reportedly reprograms splicing profiles of the insulin receptor (IR) and myocyte enhancer factor 2C (MEF2C) genes, facilitating the differentiation of brown adipocytes...
  20. Thacher P, Onyper S. Longitudinal Outcomes of Start Time Delay on Sleep, Behavior, and Achievement in High School. Sleep. 2016;39:271-81 pubmed publisher
    ..academic years (AY) 2011-2012 and 2012-2013 completed the Pittsburgh Sleep Quality Index; the DASS-21; the "Owl-Lark" Scale; the Daytime Sleepiness Index; and a brief self-report of health...
  21. Naanyu V, Vedanthan R, Kamano J, Rotich J, Lagat K, Kiptoo P, et al. Barriers Influencing Linkage to Hypertension Care in Kenya: Qualitative Analysis from the LARK Hypertension Study. J Gen Intern Med. 2016;31:304-14 pubmed publisher
    ..Individual and environmental factors are barriers to linkage to hypertension care in rural western Kenya. Our analysis provides new insights and methodological approaches that may be relevant to other low-resource settings worldwide. ..
  22. Dargas J, Chaves S, Fischer E. Pollination of lark daisy on roadsides declines as traffic speed increases along an Amazonian highway. Plant Biol (Stuttg). 2016;18:542-4 pubmed publisher
    ..Overall, results support that traffic velocity negatively affects foraging of flower visitors and the pollination of C. punctatum on roadsides. ..
  23. Lin J. Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:503-514 pubmed publisher
    ..Elevated RBM4a constituted the regulatory mechanism that led to skipping of SRPK1 exon 10...
  24. van Veelen H, Salles J, Tieleman B. Microbiome assembly of avian eggshells and their potential as transgenerational carriers of maternal microbiota. ISME J. 2018;12:1375-1388 pubmed publisher
    ..Using 16S rRNA gene sequencing, we demonstrated in both lark species, at the population and within-nest levels, that bacterial communities of freshly laid eggs were distinct ..
  25. D D, Hung K, Tarn W. RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018;38: pubmed publisher
    ..i>Rbm4a knockout brain exhibited delayed migration of late-born neurons...
  26. Ranjbar Jafarabadi A, Riyahi Bakhtiari A, Aliabadian M, Laetitia H, Shadmehri Toosi A, Yap C. First report of bioaccumulation and bioconcentration of aliphatic hydrocarbons (AHs) and persistent organic pollutants (PAHs, PCBs and PCNs) and their effects on alcyonacea and scleractinian corals and their endosymbiotic algae from the Persian Gulf,. Sci Total Environ. 2018;627:141-157 pubmed publisher
    ..PCBs and PCNs) in coral tissues, symbiotic algae (zooxanthellae), reef sediments and seawaters in coral reefs of Lark and Kharg in the Persian Gulf, Iran...
  27. Ranjbar Jafarabadi A, Riyahi Bakhtiari A, Aliabadian M, Shadmehri Toosi A. Spatial distribution and composition of aliphatic hydrocarbons, polycyclic aromatic hydrocarbons and hopanes in superficial sediments of the coral reefs of the Persian Gulf, Iran. Environ Pollut. 2017;224:195-223 pubmed publisher
    ..Some sampling sites especially Kharg, Lavan, Siri and Lark indicated higher concentration of n-alkanes due to the higher maintenance of organic matter by high clay content in ..
  28. Lin J, Chi Y, Peng H, Lu Y. RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes. Biochim Biophys Acta. 2016;1859:1368-1379 pubmed publisher
    ..In this study, we identified the discriminative splicing profiles of RNA-binding motif protein 4a-knockout (RBM4a-/-) brown adipocytes (BAs) and compared them with those of their wild-type counterparts through deep ..
  29. van Veelen H, Falcão Salles J, Tieleman B. Multi-level comparisons of cloacal, skin, feather and nest-associated microbiota suggest considerable influence of horizontal acquisition on the microbiota assembly of sympatric woodlarks and skylarks. Microbiome. 2017;5:156 pubmed publisher
    ..We propose that lark microbiota may be primarily, but not exclusively, shaped by horizontal acquisition from the regional bacterial pool ..
  30. Laiolo P, Obeso J. Multilevel selection and neighbourhood effects from individual to metapopulation in a wild passerine. PLoS ONE. 2012;7:e38526 pubmed publisher
    ..By studying a Dupont's lark Chersophilus duponti metapopulation, we analyze neighbourhood effects mediated by song repertoires on fitness ..
  31. Cunningham S, Thompson M, McKechnie A. It's cool to be dominant: social status alters short-term risks of heat stress. J Exp Biol. 2017;220:1558-1562 pubmed publisher
    ..investigated interactions between social rank and thermoregulation in three arid-zone bird species: fawn-coloured lark (Mirafra africanoides, territorial); African red-eyed bulbul (Pycnonotus nigricans, loosely social) ..
  32. Swain A, Misulovin Z, Pherson M, Gause M, Mihindukulasuriya K, Rickels R, et al. Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. PLoS Genet. 2016;12:e1006331 pubmed publisher
    ..It is unknown why some active genes bind high levels of cohesin and some do not. Here we show that the TBPH and Lark RNA-binding proteins influence association of Nipped-B and cohesin with genes and gene regulatory sequences...
  33. Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X, et al. RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site. Mol Cell Biol. 2011;31:1812-21 pubmed publisher
    ..The activity of p68 in stimulating tau exon 10 inclusion is dependent on RBM4, an intronic splicing activator...
  34. Su C, Hung K, Hung S, Tarn W. RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Mol Cell Biol. 2017;37: pubmed publisher
    b>RBM4 promotes differentiation of neuronal progenitor cells and neurite outgrowth of cultured neurons via its role in splicing regulation. In this study, we further explored the role of RBM4 in neuronal differentiation...
  35. Knopf J, Tholen S, Koczorowska M, De Wever O, Biniossek M, Schilling O. The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia. Biochim Biophys Acta. 2015;1853:2515-25 pubmed publisher
    ..In essence, we provide one of the first interactome analyses of a cell surface protease and translate these results into novel biological aspects of a marker protein for cancer-associated fibroblasts. ..
  36. Melroy Greif W, Gizer I, Wilhelmsen K, Ehlers C. Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians. Twin Res Hum Genet. 2017;20:499-510 pubmed publisher
    Diurnal preference (e.g., being an owl or lark) has been associated with several psychiatric disorders including bipolar disorder (BP), major depressive disorder, and substance use disorders...
  37. Adams E, Champagne A, Williams J, Allen H. Interfacial properties of avian stratum corneum monolayers investigated by Brewster angle microscopy and vibrational sum frequency generation. Chem Phys Lipids. 2017;208:1-9 pubmed publisher
    ..arid and semi-arid adapted larks, known to have a low CWL, were compared with lipids extracted from the SC of mesic lark species with higher CWL to gain insight into how structure impacts CWL...
  38. Jackson F, Banfi S, Guffanti A, Rossi E. A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans. Genomics. 1997;41:444-52 pubmed
    The Drosophila lark gene encodes an essential RNA-binding protein of the RNA recognition motif (RRM) class that is required during embryonic development...
  39. Tarn W, Kuo H, Yu H, Liu S, Tseng C, Dhananjaya D, et al. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Mol Biol Cell. 2016;27:1676-83 pubmed publisher
    b>RBM4 participates in cell differentiation by regulating tissue-specific alternative pre-mRNA splicing. RBM4 also has been implicated in neurogenesis in the mouse embryonic brain...
  40. Erdmann R, Blobel G. Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J Cell Biol. 1995;128:509-23 pubmed
    ..Its primary structure is 32% identical to PMP31 and PMP32 of the yeast Candida biodinii (Moreno, M., R. Lark, K. L. Campbell, and M. J. Goodman. 1994. Yeast. 10:1447-1457)...
  41. Diederichs S, Baumer N, Ji P, Metzelder S, Idos G, Cauvet T, et al. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J Biol Chem. 2004;279:33727-41 pubmed
    ..Thereby, we establish a new basis for future functional analyses of cyclin A1. We provide evidence that the cyclin A1-CDK2 complex plays a role in several signaling pathways important for cell cycle control and meiosis. ..
  42. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, et al. E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal. 2008;20:942-8 pubmed publisher
    ..Cotransfection of SIAH1 could withdraw up-regulation of TGF-beta signaling by TRB3, suggesting SIAH1-induced degradation of TRB3 represents a potential regulatory mechanism for TGF-beta signaling. ..
  43. Pfuhl T, Mamiani A, Dürr M, Welter S, Stieber J, Ankara J, et al. The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum. Neurosci Lett. 2008;444:11-5 pubmed publisher
    The RNA binding motif protein 4 genes RBM4a and RBM4b are located on human chromosome 11q13.2 and encode highly similar proteins of 363 and 359 amino acids, respectively...
  44. Markus M, Yang Y, Morris B. Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer. Genomics. 2016;107:138-44 pubmed publisher
    This study determined transcriptome-wide targets of the splicing factor RBM4 using Affymetrix GeneChip(®) Human Exon 1.0 ST Arrays and HeLa cells treated with RBM4-specific siRNA...
  45. Lin J, Tarn W, Hsieh W. Emerging role for RNA binding motif protein 4 in the development of brown adipocytes. Biochim Biophys Acta. 2014;1843:769-79 pubmed publisher
    ..Herein, we report that Rbm4a(-/-) mice exhibited hyperlipidemia accompanied with reduced mass of interscapular brown adipose tissue (iBAT)...
  46. Yong H, Zhu H, Zhang S, Zhao W, Wang W, Chen C, et al. Prognostic value of decreased expression of RBM4 in human gastric cancer. Sci Rep. 2016;6:28222 pubmed publisher
    RNA-binding motif 4 (RBM4) is a multifunctional protein that participates in regulating alternative splicing and mRNA translation...
  47. Bernert G, Fountoulakis M, Lubec G. Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain. Proteomics. 2002;2:1752-7 pubmed
    ..Some of the described proteins were only predicted and we here show the existence of the corresponding proteins in fetal human brain. ..
  48. Liang Y, Lin W, Lin Y, Lin J. The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. Oncotarget. 2015;6:38046-60 pubmed publisher
    ..Herein, we report that the upregulated miR-92a reduced the RNA-binding motif 4 (RBM4) protein expression, leading to the imbalanced expression of the neuronal polypyrimidine tract-binding (nPTB) ..
  49. Wang Y, Chen D, Qian H, Tsai Y, Shao S, Liu Q, et al. The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression. Cancer Cell. 2014;26:374-389 pubmed publisher
    ..However, the underlying molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing...
  50. Lin J, Lee Y, Tan T, Liang Y, Chuang H, Fann Y, et al. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell. Biochim Biophys Acta Mol Cell Res. 2018;1865:259-272 pubmed publisher
    ..In addition to SRSF3-mediated autoregulation, RNA-binding motif protein 4 (RBM4) constituted another mechanism in reprogramming the splicing profile of SRSF3...
  51. Zhang S, Xu X, Wang W, Yang W, Liang W. Clock gene is associated with individual variation in the activation of reproductive endocrine and behavior of Asian short toed lark. Sci Rep. 2017;7:15002 pubmed publisher
    ..of the HPG endocrine axis, and the timing of breeding behavior, in a wild population of the Asian short-toed lark (Calandrella cheleensis) in Inner Mongolia, China...
  52. Ni Y, Wang L, Liu X, Zhang H, Lin C, Fan Y. Micro-mechanical properties of different sites on woodpecker's skull. Comput Methods Biomech Biomed Engin. 2017;:1-11 pubmed publisher
    ..were selected on forehead, tempus and occiput, which were also compared with those of Eurasian Hoopoe (EH) and Lark birds (LB)...
  53. Chang S, Chang W, Lu C, Tarn W. Alanine repeats influence protein localization in splicing speckles and paraspeckles. Nucleic Acids Res. 2014;42:13788-98 pubmed publisher
    Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities...
  54. Lobo M, Lamurias A, Couto F. Identifying Human Phenotype Terms by Combining Machine Learning and Validation Rules. Biomed Res Int. 2017;2017:8565739 pubmed publisher
    ..of IHP was evaluated using the recently published HPO Gold Standardized Corpora (GSC), where the system Bio-LarK CR obtained the best F-measure of 0.56. IHP achieved an F-measure of 0.65 on the GSC...
  55. Brudecki L, Ferguson D, McCall C, El Gazzar M. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunol Cell Biol. 2013;91:532-40 pubmed publisher
    ..microRNA-146 promotes a feed-forward loop that modifies the subcellular localization of the RNA-binding protein RBM4 (RNA-binding motif protein 4) and promotes its interaction with Ago2...
  56. Markus M, Heinrich B, Raitskin O, Adams D, Mangs H, Goy C, et al. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Exp Cell Res. 2006;312:3379-88 pubmed
    ..Here we show that WT1 interacts with the novel splicing regulator RBM4. Each protein was found to colocalize in nuclear speckles and to cosediment with supraspliceosomes in glycerol ..
  57. Lin J, Lin C, Tarn W, Li F. Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events. RNA. 2014;20:1621-31 pubmed publisher
    ..In this study, we observed a correlation between the cytoplasmic accumulation of RNA-binding motif protein 4 (RBM4) and up-regulated SRPK1 in breast cancer cells...
  58. Zhang S, Xu X, Wang W, Zhao L, Gao L, Yang W. Annual variation in the reproductive hormone and behavior rhythm in a population of the Asian short-toed lark: Can spring temperature influence activation of the HPG axis of wild birds?. Horm Behav. 2017;95:76-84 pubmed publisher
    ..between spring temperature, reproductive hormones, and behavior, in a population of the Asian short-toed lark (Calandrella cheleensis) on the Inner Mongolian Grasslands in 2014, 2015 and 2016...
  59. Golding J, Dreitz V. Songbird response to rest-rotation and season-long cattle grazing in a grassland sagebrush ecosystem. J Environ Manage. 2017;204:605-612 pubmed publisher
    ..cowbird (Molothrus ater); grassland obligate species, chestnut-collared longspur (Calcarius ornatus), horned lark (Eremophila alpestris), lark bunting (Calamospiza melanocorys), McCown's longspur (Rhynchophanes mccownii), and ..
  60. Ray D, Kazan H, Chan E, Pena Castillo L, Chaudhry S, Talukder S, et al. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol. 2009;27:667-70 pubmed publisher
    ..We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1). RNAcompete identified expected and previously unknown RNA binding preferences...
  61. Huang G, Zhang Y, Liao L, Li E, Xu L. Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4. Int J Biochem Cell Biol. 2017;90:59-67 pubmed publisher
    ..assays demonstrated that TPM1-AS was located in the nucleus and interacted with RNA-binding motif protein 4 (RBM4) in human esophageal cancer cells...
  62. Petersen H, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek A, et al. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci. 2003;116:453-61 pubmed
    ..These finding suggest a model whereby megalin directly participates in transcriptional regulation through controlled sequestration or release of transcription factors via MegBP. ..