Gene Symbol: RBM25
Description: RNA binding motif protein 25
Alias: NET52, RED120, RNPC7, S164, Snu71, fSAP94, RNA-binding protein 25, Arg/Glu/Asp-rich protein, 120 kDa, RNA-binding region (RNP1, RRM) containing 7, RNA-binding region-containing protein 7, U1 small nuclear ribonucleoprotein 1SNRP homolog, arg/Glu/Asp-rich protein of 120 kDa, functional spliceosome-associated protein 94
Species: human
Products:     RBM25

Top Publications

  1. Zhou A, Ou A, Cho A, Benz E, Huang S. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Mol Cell Biol. 2008;28:5924-36 pubmed publisher
    b>RBM25 has been shown to associate with splicing cofactors SRm160/300 and assembled splicing complexes, but little is known about its splicing regulation. Here, we characterize the functional role of RBM25 in alternative pre-mRNA splicing...
  2. Gao G, Xie A, Huang S, Zhou A, Zhang J, Herman A, et al. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. Circulation. 2011;124:1124-31 pubmed publisher
    ..Two of these splicing factors, RBM25 and LUC7L3, were elevated in human heart failure tissue and mediated truncation of SCN5A mRNA in both Jurkat cells ..
  3. Ge Y, Schuster M, Pundhir S, Rapin N, Bagger F, Sidiropoulos N, et al. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Nat Commun. 2019;10:172 pubmed publisher
    ..This has led to the identification of the splicing regulator RBM25 as a novel tumor suppressor...
  4. Yang Z, Qu C, Zhang Y, Zhang W, Wang D, Gao C, et al. Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway. Oncogene. 2018;: pubmed publisher
    ..Further, we show that RBM25 binds directly to circAMOTL1L and induces its biogenesis, whereas p53 regulates EMT via direct activation of RBM25 ..
  5. Kim H, Guo F, Brahma S, Xing Y, Burkard M. Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis. Cell Cycle. 2014;13:2952-61 pubmed publisher
    ..Phosphorylation of an additional residue on MgcRacGAP at S164 is also required to elicit efficient binding...
  6. Bishof I, Dammer E, Duong D, Kundinger S, Gearing M, Lah J, et al. RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. J Biol Chem. 2018;293:11047-11066 pubmed publisher
    ..Two members of this class, LUC7L3 and RBM25, required their respective BAD domains for reciprocal interactions with U1-70K and nuclear granule localization...
  7. Stefanelli G, Gandaglia A, Costa M, Cheema M, Di Marino D, Barbiero I, et al. Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association. Sci Rep. 2016;6:28295 pubmed publisher
    ..The evolutionarily conserved serine 164 (S164) was found phosphorylated in rodent brain but its functional role has remained uncharacterized...
  8. Tse A, Li J, Chan T, Wu R, Lai K. Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma. Aquat Toxicol. 2015;165:189-96 pubmed publisher
    ..kinase (SLK), tumor necrosis factor receptor superfamily member 10b (TNFRSF10B), RNA binding motif protein 25 (RBM25), and Ubiquitin-specific-processing protease 7 (USP7), were identified...
  9. Miyamoto T, Takahashi N, Sekine M, Ogawa T, Hidaka M, Homma H, et al. Transition of serine residues to the D-form during the conversion of ovalbumin into heat stable S-ovalbumin. J Pharm Biomed Anal. 2015;116:145-9 pubmed publisher
    ..Our previous X-ray crystallographic study indicated that S-ovalbumin contains three D-Ser residues (S164, S236, and S320), which may account for its thermostability...

More Information


  1. Wang Z, Ji H, Yuan B, Wang S, Su C, Yao B, et al. ABA signalling is fine-tuned by antagonistic HAB1 variants. Nat Commun. 2015;6:8138 pubmed publisher
    ..We also identified an RNA-recognition motif-containing protein, RBM25, as a potential regulator of HAB1 alternative splicing and molecular diversity...
  2. Mohammad D, Ali R, Turunen J, Nore B, Smith C. B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing. PLoS ONE. 2016;11:e0160255 pubmed publisher
    ..Immunoblotting of two identified RNA regulatory proteins, RBM25 and MEF-2D, confirmed the proteomics data...
  3. Cheng C, Wang Z, Yuan B, Li X. RBM25 Mediates Abiotic Responses in Plants. Front Plant Sci. 2017;8:292 pubmed publisher
    ..Recently, we have shown that an Arabidopsis thaliana RNA recognition motif-containing protein RBM25 is a novel splicing factor to modulate plant response to ABA during seed germination and post-germination through ..
  4. Choi S, Kwon S, Seok S, Xiao Z, Lee K, Kang Y, et al. Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol. 2017;37: pubmed publisher
    ..Remarkably, phosphorylated S164-SIRT1 and CK2 levels were also highly elevated in liver samples of NAFLD patients and correlated with disease ..
  5. Zhan X, Qian B, Cao F, Wu W, Yang L, Guan Q, et al. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nat Commun. 2015;6:8139 pubmed publisher
    ..Here we use a forward-genetic screen to identify rbm25-1 and rbm25-2, two Arabidopsis mutants with increased sensitivity to growth inhibition by ABA...
  6. Carlson S, Soulette C, Yang Z, Elias J, Brooks A, Gozani O. RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. J Biol Chem. 2017;292:13381-13390 pubmed publisher
    ..RNA binding motif protein 25 (RBM25) is a putative splicing factor strongly conserved across eukaryotic lineages...
  7. Elisei R, Weightman D, Kendall Taylor P, Vassart G, Ludgate M. Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics. J Endocrinol Invest. 1993;16:533-40 pubmed
    ..The possible relevance of these clones to the pathogenesis of TAO is discussed as well as the limitations of this type of approach in the identification of unknown autoantigens. ..
  8. Lopes A, Domingues P, Zell R, Hale B. Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans. J Virol. 2017;91: pubmed publisher
    ..amino acid variants at the p85β interface that either enhanced (I95) or weakened (N135, T145, L161, Y161, S164) p85β binding...
  9. Noyes A, Zhou A, Gao G, Gu L, Day S, Andrew Wasserstrom J, et al. Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy. Int J Cardiol. 2017;249:282-286 pubmed publisher
    ..The changes in relative abundances of SCN5A, its variants, splicing factors RBM25 and LUC7A, and PERK, a major effector of the UPR, were analyzed by real time RT-PCR and the expression changes ..
  10. Kalabova D, Smidova A, Petrvalska O, Alblova M, Kosek D, Man P, et al. Human procaspase-2 phosphorylation at both S139 and S164 is required for 14-3-3 binding. Biochem Biophys Res Commun. 2017;493:940-945 pubmed publisher
    ..This process involves procaspase-2 phosphorylation at S164 and its binding to the scaffolding protein 14-3-3...
  11. Gocke C, Yu H, Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem. 2005;280:5004-12 pubmed
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms. ..
  12. Gong D, Yang F, Li F, Qian D, Wu M, Shao Z, et al. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. Biochem J. 2013;450:85-94 pubmed publisher
    Human RBM25 (RNA-binding motif protein 25) is a novel splicing factor that contains a PWI domain, a newly identified RNA/DNA-binding domain, and regulates Bcl-x pre-mRNA alternative splicing...
  13. Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995;375:754-60 pubmed
    ..Because these changes occurred in conserved domains of this gene, and are not present in normal controls, they are likely to be causative of AD3. ..
  14. Kanno T, Lin W, Fu J, Chang C, Matzke A, Matzke M. A Genetic Screen for Pre-mRNA Splicing Mutants of Arabidopsis thaliana Identifies Putative U1 snRNP Components RBM25 and PRP39a. Genetics. 2017;207:1347-1359 pubmed publisher
    ..we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger RNA (pre-mRNA) splicing in plants...
  15. Cheng A, Fan C, Lo Y, Kuo C, Wang H, Lien I, et al. Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Sci Rep. 2017;7:17024 pubmed publisher
    ..Using a phosphoproteome approach, we identified HSP90-S164 as a target of Cdc7-Dbf4 in vitro and in vivo...
  16. Fortes P, Longman D, McCracken S, Ip J, Poot R, Mattaj I, et al. Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. FEBS Lett. 2007;581:3087-97 pubmed
    ..These results suggest that RED120 may function to couple splicing with mRNA 3'-end formation.