RBBP8

Summary

Gene Symbol: RBBP8
Description: RB binding protein 8, endonuclease
Alias: COM1, CTIP, JWDS, RIM, SAE2, SCKL2, DNA endonuclease RBBP8, CTBP-interacting protein, RBBP-8, retinoblastoma binding protein 8, sporulation in the absence of SPO11 protein 2 homolog
Species: human
Products:     RBBP8

Top Publications

  1. Eid W, Steger M, El Shemerly M, Ferretti L, Pena Diaz J, König C, et al. DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep. 2010;11:962-8 pubmed publisher
    ..breaks (DSBs) by homologous recombination-relies first on the partnership between MRE11-RAD50-NBS1 (MRN) and CtIP, followed by a processive step involving helicases and exonucleases such as exonuclease 1 (EXO1)...
  2. Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol. 2004;24:9478-86 pubmed
    ..We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a phosphorylation-dependent manner...
  3. Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cell Physiol Biochem. 2012;30:596-608 pubmed publisher
    ..Finally, the co-regulator of transcription CtIP increases ATM transcription. CtIP increases ATM transcription...
  4. Schaeper U, Subramanian T, Lim L, Boyd J, Chinnadurai G. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J Biol Chem. 1998;273:8549-52 pubmed
    ..Here, we report the cloning and characterization of a 125-kDa protein, CtIP, that binds with CtBP through the PLDLS motif...
  5. Yu X, Wu L, Bowcock A, Aronheim A, Baer R. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem. 1998;273:25388-92 pubmed
    ..Our results show that the BRCT domains interact in vivo with CtIP, a protein originally identified on the basis of its association with the CtBP transcriptional co-repressor...
  6. Sartori A, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, et al. Human CtIP promotes DNA end resection. Nature. 2007;450:509-14 pubmed
    ..Previous work has implicated the MRE11 complex in such DSB-processing events. Here, we show that the human CtIP (RBBP8) protein confers resistance to DSB-inducing agents and is recruited to DSBs exclusively in the S and G2 cell-cycle ..
  7. Meloni A, Smith E, Nevins J. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A. 1999;96:9574-9 pubmed
    ..with the Rb-related p130 protein, we demonstrate that p130, as well as Rb, interacts with a protein known as CtIP. This interaction depends on the p130 pocket domain, which is important for repression activity, as well as an ..
  8. Tischkowitz M, Hamel N, Carvalho M, Birrane G, Soni A, van Beers E, et al. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur J Hum Genet. 2008;16:820-32 pubmed publisher
    ..pocket of the BRCA1 BRCT domains, thereby inhibiting the BRCA1 interaction with the proteins BRIP1 and CtIP, which are involved in DNA damage-induced checkpoint control...
  9. Li S, Ting N, Zheng L, Chen P, Ziv Y, Shiloh Y, et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. 2000;406:210-5 pubmed
    ..Here we show that the BRCA1-associated protein CtIP becomes hyperphosphorylated and dissociated from BRCA1 upon ionizing radiation...

More Information

Publications78

  1. Gorringe K, Choong D, Lindeman G, Visvader J, Campbell I. Breast cancer risk and the BRCA1 interacting protein CTIP. Breast Cancer Res Treat. 2008;112:351-2 pubmed
    Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk...
  2. Koipally J, Georgopoulos K. Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. J Biol Chem. 2002;277:23143-9 pubmed
    ..Consistent with this expectation, we show that Ikaros can interact with a CtBP-interacting protein (CtIP), which has also been linked to a deacetylase-independent strategy of repression...
  3. Greenberg R, Sobhian B, Pathania S, Cantor S, Nakatani Y, Livingston D. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 2006;20:34-46 pubmed
    ..The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions. ..
  4. Sutherland K, Visvader J, Choong D, Sum E, Lindeman G, Campbell I. Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. Int J Cancer. 2003;107:155-8 pubmed
    ..This mutant protein could still bind Ldb1 but no longer associated with CtIP or BRCA1...
  5. Liu F, Lee W. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol. 2006;26:3124-34 pubmed
    ..Previously we showed that the presence of CtIP is essential for G(1)/S transition in primary mouse blastocysts, as well as in NIH 3T3 cells...
  6. Huertas P, Jackson S. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem. 2009;284:9558-65 pubmed publisher
    ..The human CtIP protein controls double strand break (DSB) resection, an event that occurs effectively only in S/G(2) and that ..
  7. Rebbeck T, Mitra N, Domchek S, Wan F, Chuai S, Friebel T, et al. Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Cancer Res. 2009;69:5801-10 pubmed publisher
    ..A cohort of 1,575 BRCA1 and 856 BRCA2 mutation carriers was used to evaluate haplotypes at ATM, BARD1, BRIP1, CTIP, MRE11, NBS1, RAD50, RAD51, and TOPBP1 in ovarian cancer risk...
  8. Germani A, Prabel A, Mourah S, Podgorniak M, Di Carlo A, Ehrlich R, et al. SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene. 2003;22:8845-51 pubmed
    ..Using a two-hybrid screening, we identified here the transcriptional corepressor CtBP-interacting protein (CtIP) as a SIAH-1-interacting protein...
  9. Wu M, Soler D, Abba M, Nunez M, Baer R, Hatzis C, et al. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol Cancer Res. 2007;5:1285-95 pubmed publisher
    ..Using serial analysis of gene expression, we identified CtIP, a BRCA1- and CtBP-interacting protein, as one of the most significantly down-regulated transcripts in estrogen ..
  10. Huertas P, Cortes Ledesma F, Sartori A, Aguilera A, Jackson S. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature. 2008;455:689-92 pubmed publisher
    ..in Saccharomyces cerevisiae results from the phosphorylation by CDK of an evolutionarily conserved motif in the Sae2 protein...
  11. Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev. 2006;20:1721-6 pubmed
    ..Here, we demonstrate that BRCA1 Ring domain catalyzes CtIP ubiquitination in a manner that depends on a phosphorylation-mediated interaction between CtIP and BRCA1 BRCT ..
  12. Chen L, Nievera C, Lee A, Wu X. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem. 2008;283:7713-20 pubmed publisher
    ..Here we describe that BRCA1 forms a complex with CtIP and MRN (Mre11/Rad50/Nbs1) in a cell cycle-dependent manner...
  13. Fusco C, Reymond A, Zervos A. Molecular cloning and characterization of a novel retinoblastoma-binding protein. Genomics. 1998;51:351-8 pubmed
    ..Rim mRNA is expressed ubiquitously at low levels in all human adult tissues tested and at much higher levels in several tumor cell lines. The Rim gene (HGMW-approved symbol RBBP8) is localized on human chromosome 18q11.2.
  14. Qvist P, Huertas P, Jimeno S, Nyegaard M, Hassan M, Jackson S, et al. CtIP Mutations Cause Seckel and Jawad Syndromes. PLoS Genet. 2011;7:e1002310 pubmed publisher
    ..We previously mapped a Seckel syndrome locus to chromosome 18p11.31-q11.2 (SCKL2)...
  15. Sum E, Peng B, Yu X, Chen J, Byrne J, Lindeman G, et al. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem. 2002;277:7849-56 pubmed
    ..Using LMO4 in a yeast two-hybrid screen, we have identified the cofactor CtIP as an LMO4-binding protein...
  16. Wang H, Shi L, Wong C, Han X, Hwang P, Truong L, et al. The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet. 2013;9:e1003277 pubmed publisher
    b>CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively...
  17. Bruton R, Rasti M, Mapp K, Young N, Carter R, Abramowicz I, et al. C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3. Oncogene. 2007;26:7467-79 pubmed
    C-terminal-binding protein interacting protein (CtIP) was first isolated as a binding partner of C-terminal-binding protein (CtBP)...
  18. You Z, Shi L, Zhu Q, Wu P, Zhang Y, Basilio A, et al. CtIP links DNA double-strand break sensing to resection. Mol Cell. 2009;36:954-69 pubmed publisher
    ..Using Xenopus egg extracts and human cells, we show that the tumor suppressor protein CtIP plays a critical role in this transition...
  19. Li S, Chen P, Subramanian T, Chinnadurai G, Tomlinson G, Osborne C, et al. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J Biol Chem. 1999;274:11334-8 pubmed
    ..A known protein, CtIP, a co-repressor with CtBP, was found...
  20. Ahmed K, Tsai C, Lee W. Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis. J Biol Chem. 2010;285:4464-71 pubmed publisher
    ..microarray analysis, we found that HMGA2, along with a dozen of other genes, was co-repressed by ZBRK1, BRCA1, and CtIP. BRCA1 exerts its transcriptional repression activity through interaction with the transcriptional repressor ZBRK1 ..
  21. Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez B. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol. 2009;16:819-24 pubmed publisher
    ..Silencing of Rad50 or CtIP decreases end-joining efficiency in the same pathway as Mre11...
  22. Wang H, Shao Z, Shi L, Hwang P, Truong L, Berns M, et al. CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem. 2012;287:21471-80 pubmed publisher
    b>CtIP (CtBP-interacting protein) associates with BRCA1 and the Mre11-Rad50-Nbs1 (MRN) complex and plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair...
  23. Escribano D az C, Orthwein A, Fradet Turcotte A, Xing M, Young J, Tk J, et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell. 2013;49:872-83 pubmed publisher
    ..Remarkably, RIF1 accumulation at DSB sites is strongly antagonized by BRCA1 and its interacting partner CtIP. Lastly, we show that depletion of RIF1 is able to restore end resection and RAD51 loading in BRCA1-depleted cells...
  24. Sevcik J, Falk M, Macurek L, Kleiblova P, Lhota F, Hojny J, et al. Expression of human BRCA1?17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response. Cell Signal. 2013;25:1186-93 pubmed publisher
    ..Mechanistically, BRCA1?17-19 cannot interact with the partner proteins Abraxas and CtIP, thus preventing interactions known to be critical for processing of DNA lesions...
  25. Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem. 2009;284:31746-52 pubmed publisher
    ..CtIP (also known as RBBP8) acts together with the MRN (MRE11-RAD50-NBS1) complex to promote DNA end resection and the generation of single-..
  26. Coleman K, Greenberg R. The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection. J Biol Chem. 2011;286:13669-80 pubmed publisher
    ..RAP80 or BRCC36 deficiency resulted in elevated Mre11-CtIP-dependent 5' end resection with a concomitant increase in HDR mechanisms that rely on 3' single-stranded overhangs...
  27. Gu B, Chen P. Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle. 2009;8:1409-20 pubmed
    b>CtIP, CtBP-interacting protein, is a nuclear protein that was identified as a cofactor for the transcriptional repressor CtBP...
  28. Uanschou C, Siwiec T, Pedrosa Harand A, Kerzendorfer C, Sanchez Moran E, Novatchkova M, et al. A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene. EMBO J. 2007;26:5061-70 pubmed
    ..In Saccharomyces cerevisiae, Rad50, Mre11 and Com1/Sae2 are essential to process an intermediate of the cleavage reaction consisting of Spo11 covalently linked to the ..
  29. Xu J, Lv S, Qin Y, Shu F, Xu Y, Chen J, et al. TRB3 interacts with CtIP and is overexpressed in certain cancers. Biochim Biophys Acta. 2007;1770:273-8 pubmed
    ..Here we found that TRB3 interacted with an important cell cycle regulator CtIP (CtBP-interacting protein) and the interaction involved the C-terminus of both proteins...
  30. Børglum A, Balslev T, Haagerup A, Birkebaek N, Binderup H, Kruse T, et al. A new locus for Seckel syndrome on chromosome 18p11.31-q11.2. Eur J Hum Genet. 2001;9:753-7 pubmed
    ..31-q11.2. This second locus for Seckel syndrome demonstrates genetic heterogeneity and brings us a step further towards molecular genetic delineation of this heterogeneous condition. ..
  31. Yu X, Baer R. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J Biol Chem. 2000;275:18541-9 pubmed
    ..b>CtIP was recently identified as a protein that associates with BRCA1 and two other nuclear factors, CtBP1 and Rb1...
  32. Wong A, Ormonde P, Pero R, Chen Y, Lian L, Salada G, et al. Characterization of a carboxy-terminal BRCA1 interacting protein. Oncogene. 1998;17:2279-85 pubmed
    ..Using the yeast two-hybrid and in vitro biochemical assays, we show that a protein, CtIP, interacts specifically with the carboxy-terminal segment of human BRCA1 from residues 1602-1863...
  33. Wang B, Matsuoka S, Ballif B, Zhang D, Smogorzewska A, Gygi S, et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007;316:1194-8 pubmed
    ..Abraxas binds BRCA1 to the mutual exclusion of BACH1 (BRCA1-associated C-terminal helicase) and CtIP (CtBP-interacting protein), forming a third type of BRCA1 complex...
  34. Yun M, Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature. 2009;459:460-3 pubmed publisher
    ..Here we identify a role for CtIP (also known as RBBP8) in this process in the avian B-cell line DT40...
  35. Furuta S, Wang J, Wei S, Jeng Y, Jiang X, Gu B, et al. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006;10:13-24 pubmed
    BRCA1 exerts transcriptional repression through interaction with CtIP in the C-terminal BRCT domain and ZBRK1 in the central domain...
  36. Singh G, Yadav V, Singh P, Bhowmik K. Radiation-Induced Malignancies Making Radiotherapy a "Two-Edged Sword": A Review of Literature. World J Oncol. 2017;8:1-6 pubmed publisher
    ..Mutagenesis of normal tissues is the basis for RIMs. The aim of this review of literature was to discuss epidemiology, factors affecting and different settings in which RIM occur.
  37. Yu Y, Xiao Y, Cheng J, Chiu B. Breast lesion classification based on supersonic shear-wave elastography and automated lesion segmentation from B-mode ultrasound images. Comput Biol Med. 2018;93:31-46 pubmed publisher
    ..In addition, rich diagnostic features were available along the rim surrounding the lesion...
  38. Amini N, Daneshvar R, Sharifipour F, Romero P, Henry S, Caprioli J, et al. Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters. Invest Ophthalmol Vis Sci. 2017;58:4623-4631 pubmed publisher
    ..1) structure-function (SF) relationships between visual fields (VF) and Bruch's membrane opening-based minimum rim width (BMO-MRW) measurements are superior to those for peripapillary retinal nerve fiber layer (pRNFL) in ..
  39. Suzuki K, Yamada K, Nakada K, Suzuki Y, Watanabe M, Kwee I, et al. MRI characteristics of the glia limitans externa: A 7T study. Magn Reson Imaging. 2017;44:140-145 pubmed publisher
    To perform a systematic analysis of the intrinsic contrast parameters of the FLAIR hyperintense rim (FHR), a thin layer of high intensity covering the entire surface of the cerebral cortex detected on fluid-attenuated inversion recovery (..
  40. Padmaja R, Halami P. Taming C-terminal peptides of Staphylococcus aureus leukotoxin M for B-cell response: Implication in improved subclinical bovine mastitis diagnosis and protective efficacy in vitro. Toxicon. 2016;119:99-105 pubmed publisher
    ..produced by bovine mastitis causing Staphylococcus aureus structurally comprises three domains, the ?-sandwich, rim and stem domain...
  41. Wu Q, Paul A, Su D, Mehmood S, Foo T, Ochi T, et al. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol Cell. 2016;61:434-448 pubmed publisher
    ..containing the phosphorylated serine-proline-x-phenylalanine (pSPxF) motif including Abraxas, Bach1/FancJ, and CtIP. In this study, we demonstrate that ionizing radiation (IR)-induces ATM-dependent phosphorylation of serine 404 (..
  42. Kim G, Jung H, Kim J, Lee Y. Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor. PLoS ONE. 2015;10:e0132680 pubmed publisher
    ..presentation of the SRID mutations on the HDAC4c structure revealed that most of the mutations were mapped to the rim surface of the catalytic entry site, strongly suggesting this mutational hot-spot region as the major binding ..
  43. Liu Y, Perez L, Mettry M, Gill A, Byers S, Easley C, et al. Site selective reading of epigenetic markers by a dual-mode synthetic receptor array. Chem Sci. 2017;8:3960-3970 pubmed publisher
    ..The hosts bind trimethyllysine (KMe3) groups, and use secondary upper rim interactions to provide more sensitive discrimination between targets with identical KMe3 binding ..
  44. Islam M, Sobhan M, Rahman A, Rahman M, Hossain M, Fatema N. Management of Infected Sebaceous Cyst by Suture Closure: A New Approach. Mymensingh Med J. 2017;26:828-830 pubmed
    ..Under local or general anesthesia the infected tissue is excised along with a rim of healthy tissue and then closed by Prolene in the same sitting...
  45. Wang Z, Fang C. Spatial-temporal characteristics and determinants of PM2.5 in the Bohai Rim Urban Agglomeration. Chemosphere. 2016;148:148-62 pubmed publisher
    ..This paper adopts the PM2.5 concentration data obtained from 241 newly located observation points in the Bohai Rim Urban Agglomeration (BRUA), as well as economic, urban and industrial working population data in the study area, ..
  46. Yen T, Lee G, Chai J, Liao J, Lau J, Hu L, et al. Characterization of a murine xenograft model for contrast agent development in breast lesion malignancy assessment. J Biomed Sci. 2016;23:46 pubmed publisher
    ..wide (axis parallel to skin) with angular/ill-defined margin under sonogram observations, revealed more evident rim enhancement, angular margin and washout pattern in the time-density curve from dynamic contrast enhance multi-..
  47. Wuerges J, Caputi L, Cianci M, Boivin S, Meijers R, Benini S. The crystal structure of Erwinia amylovora levansucrase provides a snapshot of the products of sucrose hydrolysis trapped into the active site. J Struct Biol. 2015;191:290-8 pubmed publisher
    ..propose the structural features, determining the different reaction products, to reside in just a few loops at the rim of the active site funnel...
  48. Pogorzelski J, Braun S, Imhoff A, Beitzel K. [Open-wedge osteotomy of the glenoid for treatment of posterior shoulder instability with increased glenoid retroversion]. Oper Orthop Traumatol. 2016;28:438-448 pubmed
    ..The osteotomy is performed intracapsulary medial to the genoid rim. The wedge bone graft, harvested from spina scapulae or iliac spine, is placed "press fit" in position...
  49. Davies O, Forment J, Sun M, Belotserkovskaya R, Coates J, Galanty Y, et al. CtIP tetramer assembly is required for DNA-end resection and repair. Nat Struct Mol Biol. 2015;22:150-157 pubmed publisher
    Mammalian CtIP protein has major roles in DNA double-strand break (DSB) repair...
  50. Liu J, Zhou L, Liang J, Lu M, Wang W. Contrast-enhanced ultrasound findings in a case of primary chest chondrosarcoma mimicking a porta hepatis mass. J Med Ultrason (2001). 2015;42:267-70 pubmed publisher
    ..contrast depicted a huge well-demarcated heterogeneous mass at the porta hepatis with irregular peripheral rim enhancement...
  51. Paquet C, Choroomi S, Frankel A. An Analysis of Lateral Crural Repositioning and Its Effect on Alar Rim Position. JAMA Facial Plast Surg. 2016;18:89-94 pubmed publisher
    Cephalically malpositioned lateral crura are a frequent cause of alar rim retraction during both primary and revision rhinoplasty...
  52. Rich L, Sexton S, Curtin L, Seshadri M. Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer. Transl Oncol. 2017;10:839-845 pubmed publisher
    ..PAI revealed considerable intratumoral spatial heterogeneity with the tumor rim showing two- to three-fold higher %sO2 values compared to the core...
  53. Xuan Z, Manning L, Nelson J, Richmond J, COLON RAMOS D, Shen K, et al. Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release. elife. 2017;6: pubmed publisher
    ..containing common C-terminal PDZ and C2 domains with homology to vertebrate active zone proteins Piccolo and RIM. The C-termini of all isoforms localize to the active zone...
  54. Sagami R, Nishikiori H, Ikuyama S, Murakami K. Rupture of small cystic pancreatic neuroendocrine tumor with many microtumors. World J Gastroenterol. 2017;23:6911-6919 pubmed publisher
    ..Two microtumors about 7 mm in diameter in the pancreatic body detected only by EUS, cystic rim and nodules all showed similar enhancement on contrast-harmonic EUS...
  55. Reznicek L, Burzer S, Laubichler A, Nasseri A, Lohmann C, Feucht N, et al. Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma. Int J Ophthalmol. 2017;10:1534-1538 pubmed publisher
    ..compare structural optical coherence tomography (OCT)-based parameters, such as Bruch's membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects,..
  56. Volcic M, Karl S, Baumann B, Salles D, Daniel P, Fulda S, et al. NF-?B regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes. Nucleic Acids Res. 2012;40:181-95 pubmed publisher
    ..Additionally, we provide evidence that NF-?B interacts with CtIP-BRCA1 complexes and promotes BRCA1 stabilization, and thereby contributes to HR induction...
  57. Ye Q, Hu Y, Zhong H, Nye A, Belmont A, Li R. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol. 2001;155:911-21 pubmed
    ..These results indicate that reorganization of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions. ..
  58. Stpiczyńska M, Płachno B, Davies K. Nectar and oleiferous trichomes as floral attractants in Bulbophyllum saltatorium Lindl. (Orchidaceae). Protoplasma. 2018;255:565-574 pubmed publisher
    ..types of unicellular trichomes: the longest trichomes are borne distally and abaxially; the marginal ones form a rim around the entire labellum, and finally, massive, capitate trichomes occur proximally and adaxially...
  59. Chao C, Zhangm Z, Weissenberger G, Chen H, Ching W. Lateral Flow Rapid Test for Accurate and Early Diagnosis of Scrub Typhus: A Febrile Illness of Historically Military Importance in the Pacific Rim. Mil Med. 2017;182:369-375 pubmed publisher
    ..This product will provide a user friendly, rapid, and accurate diagnosis of ST for clinicians to provide timely and accurate treatments of deployed personnel...
  60. Wang T, Jones R, Whippen J, Davis G. ?2?-3 Is Required for Rapid Transsynaptic Homeostatic Signaling. Cell Rep. 2016;16:2875-2888 pubmed publisher
    ..rapid induction and sustained expression of PHP due to a failure to potentiate presynaptic calcium influx and the RIM-dependent readily releasable vesicle pool...
  61. Yeo J, Lee E, Hendrickson E, Sobeck A. CtIP mediates replication fork recovery in a FANCD2-regulated manner. Hum Mol Genet. 2014;23:3695-705 pubmed publisher
    ..One such candidate is CtIP (CtBP-interacting protein), a key HR repair factor that functions in complex with BRCA1 and MRE11, but has not been ..
  62. San Millan Ruiz D, Burkhardt K, Jean B, Muster M, Martin J, Bouvier J, et al. Pathology findings with acrylic implants. Bone. 1999;25:85S-90S pubmed
    ..PMMA exhibited a macroscopic and microscopic rim of tumor necrosis, 6 months after implantation...
  63. ZHu B, Su C, He Y, Chai X, Li Z, Hou Z, et al. Combined anteversion technique in total hip arthroplasty for Crowe IV developmental dysplasia of the hip. Hip Int. 2017;27:589-594 pubmed publisher
    ..If the cup is fixed with normal anteversion, the anterior rim will be excessively exposed, which reduces the contact areas of the cup and bone, affects prosthesis stability, and ..
  64. Gan L, Zhou Z, Xin N. Synthesis of Metal Complexes with an Open-cage Fullerene as the Ligand. Chemistry. 2017;: pubmed publisher
    An open-cage C60 derivative 9 with anilino, hemiketal and lactone moieties on the rim of the orifice was prepared through a fullerene-mixed peroxide procedure...
  65. Beutler B, Cohen P. Angiokeratoma of the Glans Penis. Skinmed. 2017;15:343-347 pubmed
    ..5 to 5 mm and present as red, purple, blue, or black lesions along the penile coronal rim. Histopathologic examination of the lesions reveals dilated, thin-walled vascular structures in the upper portion ..
  66. Kuan M, O Dowd J, Fortunato E. The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress. Virology. 2016;497:262-278 pubmed publisher
    ..Re-introduction of p53 into p53KOs largely recovered UL53 positivity and UL50 nuclear re-localization. Nuclear rim located UL50/53 puncta, which co-localized with the major capsid protein, were largely absent in p53KOs...
  67. Makharashvili N, Paull T. CtIP: A DNA damage response protein at the intersection of DNA metabolism. DNA Repair (Amst). 2015;32:75-81 pubmed publisher
    The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination...
  68. Buteikienė D, Kybartaitė Žilienė A, Kriauciuniene L, Barzdziukas V, Januleviciene I, Paunksnis A. Morphometric parameters of the optic disc in normal and glaucomatous eyes based on time-domain optical coherence tomography image analysis. Medicina (Kaunas). 2017;53:242-252 pubmed publisher
    ..Areas and shapes of the disc, cup, and neuroretinal rim were analyzed. The shape of the optic disc did not differ between the study groups, i.e...
  69. Hölscher T, Weber T, Lazarev I, Englert C, Dendorfer S. Influence of rotator cuff tears on glenohumeral stability during abduction tasks. J Orthop Res. 2016;34:1628-35 pubmed publisher
    ..cuff muscles (supraspinatus; infraspinatus) leads to a deviation of the joint reaction force to the cranial dorsal rim of the glenoid...