RbAp48

Summary

Gene Symbol: RbAp48
Description: retinoblastoma binding protein 4
Alias: NURF55, RBAP48, CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, MSI1 protein homolog, RBBP-4, chromatin assembly factor 1 subunit C, chromatin assembly factor I p48 subunit, chromatin assembly factor/CAF-1 p48 subunit, histone-binding protein RBBP4, nucleosome-remodeling factor subunit RBAP48, retinoblastoma-binding protein 4, retinoblastoma-binding protein p48
Species: human

Top Publications

  1. ncbi Cloning and molecular characterization of the Schistosoma mansoni genes RbAp48 and histone H4
    Patricia P Souza
    Laboratorio de Genetica Bioquimica, Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Mem Inst Oswaldo Cruz 97:77-84. 2002
  2. doi Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
    Mutat Res 642:57-67. 2008
  3. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
  4. pmc The program for processing newly synthesized histones H3.1 and H4
    Eric I Campos
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 17:1343-51. 2010
  5. doi CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex
    Cornelia G Spruijt
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Biosyst 6:1700-6. 2010
  6. ncbi Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase
    A Verreault
    Cold Spring Harbor Laboratory, P O Box 100, Cold Spring Harbor, New York 11724, USA
    Curr Biol 8:96-108. 1998
  7. ncbi NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
    Y Xue
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
    Mol Cell 2:851-61. 1998
  8. pmc Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex
    Sara Lejon
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 286:1196-203. 2011
  9. pmc Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    Andrei Kuzmichev
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 16:2893-905. 2002
  10. pmc Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
    Joanna Wysocka
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Genes Dev 17:896-911. 2003

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. ncbi Cloning and molecular characterization of the Schistosoma mansoni genes RbAp48 and histone H4
    Patricia P Souza
    Laboratorio de Genetica Bioquimica, Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Mem Inst Oswaldo Cruz 97:77-84. 2002
    The human nuclear protein RbAp48 is a member of the tryptophan/aspartate (WD) repeat family, which binds to the retinoblastoma (Rb) protein...
  2. doi Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
    Mutat Res 642:57-67. 2008
    ....
  3. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
    ..This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication...
  4. pmc The program for processing newly synthesized histones H3.1 and H4
    Eric I Campos
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 17:1343-51. 2010
    ..We further demonstrate the high degree of conservation for this pathway between higher and lower eukaryotes...
  5. doi CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex
    Cornelia G Spruijt
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Biosyst 6:1700-6. 2010
    ..Finally, immunofluorescence experiments reveal co-localization between MBD2 and DOC-1 in mouse NIH-3T3 nuclei. Collectively, these results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex...
  6. ncbi Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase
    A Verreault
    Cold Spring Harbor Laboratory, P O Box 100, Cold Spring Harbor, New York 11724, USA
    Curr Biol 8:96-108. 1998
    ..The identification of enzymes mediating site-specific acetylation of H4 at Lys5 and Lys12 may help explain the function of the acetylation of newly synthesized histones...
  7. ncbi NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
    Y Xue
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
    Mol Cell 2:851-61. 1998
    ..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin...
  8. pmc Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex
    Sara Lejon
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 286:1196-203. 2011
    ..Here, we present the 1.9 Å resolution crystal structure of the NuRD subunit RbAp48 bound to the 15 N-terminal amino acids of the GATA-1 cofactor FOG-1...
  9. pmc Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    Andrei Kuzmichev
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 16:2893-905. 2002
    ..complex that contains extra sex combs, suppressor of zeste-12 [Su(z)12], and the histone binding proteins RbAp46/RbAp48. This complex, which we termed Polycomb repressive complex (PRC) 2, possesses HMT activity with specificity for ..
  10. pmc Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
    Joanna Wysocka
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Genes Dev 17:896-911. 2003
    ..These results suggest that HCF-1 can broadly regulate transcription, both positively and negatively, through selective modulation of chromatin structure...
  11. pmc Ageing-related chromatin defects through loss of the NURD complex
    Gianluca Pegoraro
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Cell Biol 11:1261-7. 2009
    ..These results outline a molecular mechanism for chromatin defects during ageing...
  12. ncbi The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
    Y Zhang
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA
    Cell 95:279-89. 1998
    ..The finding that Mi2beta exists in a complex containing histone deacetylase and nucleosome remodeling activities suggests a role for chromatin reorganization in cancer metastasis...
  13. ncbi Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle
    K Marheineke
    Wellcome Cancer Research Campaign Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom and the Department of Zoology, University of Cambridge, United Kingdom
    J Biol Chem 273:15279-86. 1998
    ..In mitosis, the p60 subunit of inactive CAF-1 is hyperphosphorylated, whereas active CAF-1 in interphase contains hypophosphorylated and/or phosphorylated forms of p60...
  14. doi Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress
    Jill A Opsahl
    Proteomic Unit PROBE, Department of Biomedicine, University of Bergen, Bergen, Norway
    Proteomics 10:1494-504. 2010
    ..The observed interaction between DJ-1 and the NuRD complex may give new clues to how DJ-1 can protect cells from p53-dependent cell death...
  15. ncbi Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
    J K Tong
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 395:917-21. 1998
    ..Our results establish a physical and functional link between the distinct chromatin-modifying activities of histone deacetylases and nucleosome remodelling proteins...
  16. ncbi The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    Mark S Lechner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 331:929-37. 2005
    ..Thus, this spectrum of direct binding partners suggests an expanded role for HP1 as factor participating in promoter-enhancer communication, chromatin remodeling/assembly, and sub-nuclear compartmentalization...
  17. ncbi Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1
    J Taplick
    Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, Austria
    J Mol Biol 308:27-38. 2001
    ..Furthermore, the same HDAC1 domain is also necessary for in vitro binding of HDAC2 and HDAC3, association with RbAp48 and for catalytic activity of the enzyme...
  18. ncbi Histone deacetylase 1 phosphorylation at S421 and S423 is constitutive in vivo, but dispensable in vitro
    Paulina Karwowska-Desaulniers
    Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA
    Biochem Biophys Res Commun 361:349-55. 2007
    ..of HDAC1 demonstrated that binding to Sin3A is promoted by S421 and S423 phosphorylation, while interaction with RbAp48 is not...
  19. ncbi Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation
    M K Pflum
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    J Biol Chem 276:47733-41. 2001
    ..Our results reinforce the importance of protein associations in modulating HDAC1 function and provide the first step toward characterizing the role of post-translational modifications in regulating HDAC activity in vivo...
  20. ncbi ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
    Tatsuya Nakamura
    Kimmel Cancer Center and Department of Microbiology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Mol Cell 10:1119-28. 2002
    ..In parallel, H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter...
  21. ncbi A retinoblastoma-binding protein related to a negative regulator of Ras in yeast
    Y W Qian
    Center for Molecular Medicine, University of Texas, Health Science Center, San Antonio 78245 3207
    Nature 364:648-52. 1993
    ..Here we report the isolation of a full-length complementary DNA (RbAp48) encoding p48...
  22. pmc Isolation of human NURF: a regulator of Engrailed gene expression
    Orr Barak
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    EMBO J 22:6089-100. 2003
    ..Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth...
  23. pmc The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex
    Andrea E Roche
    The Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA
    J Mol Cell Cardiol 44:352-60. 2008
    ..we demonstrate that Metastasis-Associated proteins (MTA)-1, 2 and 3 and Retinoblastoma binding proteins RbAp46 and RbAp48 interact with FOG-2, but not with a mutant form of FOG-2 that is unable to repress transcription...
  24. pmc A CAF-1 dependent pool of HP1 during heterochromatin duplication
    Jean Pierre Quivy
    Institut Curie, Section de Recherche, UMR218 du CNRS, 26, Paris, France
    EMBO J 23:3516-26. 2004
    ....
  25. ncbi A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
    C Underhill
    Departments of Pharmacology and Toxicology, Oncology, and Biochemistry, Cancer Research Laboratories, London Regional Cancer Centre, The University of Western Ontario, London, Ontario, Canada
    J Biol Chem 275:40463-70. 2000
    ..These results suggest that N-CoR is found in distinct multiprotein complexes, which are involved in multiple pathways of transcriptional repression...
  26. ncbi TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    Pooja Pungaliya
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
    J Proteome Res 6:3918-23. 2007
    ..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification...
  27. ncbi ATP-Dependent histone octamer mobilization and histone deacetylation mediated by the Mi-2 chromatin remodeling complex
    D Guschin
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Building 18T, Room 106, Bethesda, Maryland 20892 5431, USA
    Biochemistry 39:5238-45. 2000
    ..Here, we use a purified Mi-2 complex containing six components, Mi-2, Mta 1-like, p66, RbAp48, RPD3, and MBD3, to investigate the capacity of this complex to destabilize histone-DNA interactions and ..
  28. ncbi RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein
    E Nicolas
    Laboratoire de Biologie Moleculaire Eucaryote, UPR 9006 CNRS, 118 route de Narbonne, 31 062 Toulouse Cedex, France
    J Biol Chem 275:9797-804. 2000
    ..The Rb-associated protein RbAp48 belongs to many histone deacetylase complexes...
  29. ncbi Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4
    A Verreault
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 87:95-104. 1996
    ..Our data suggest that CAC is a key intermediate of the de novo nucleosome assembly pathway and that the p48 subunit participates in other aspects of histone metabolism...
  30. pmc The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein
    E Nicolas
    Laboratoire de Biologie Moleculaire Eucaryote, UMR 5099 CNRS, 118 route de Narbonne, F 31062 Toulouse Cedex, France and Institut André Lwoff, UPR 9079 CNRS, Villejuif, France
    Nucleic Acids Res 29:3131-6. 2001
    ..Recently, we have shown that the Rb-associated histone deacetylase complex contains RbAp48 protein, which interacts with HDAC1 and HDAC2...
  31. pmc Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
    Y Zhang
    Howard Hughes Medical Institute HHMI, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 13:1924-35. 1999
    ..The histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3-histone deacetylase complexes...
  32. ncbi Histone deacetylase activity is required for full transcriptional repression by mSin3A
    C A Hassig
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 89:341-7. 1997
    ..mSin3A-targeted repression of a reporter gene is reduced by trapoxin treatment, suggesting that histone deacetylation mediates transcriptional repression through Mad-Max-mSin3A multimeric complexes...
  33. ncbi Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
    Y Zhang
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA
    Cell 89:357-64. 1997
    ..Moreover, we demonstrate a direct interaction between SAP18 and mSin3. SAP18 represses transcription in vivo when tethered to the promoter, consistent with the ability of SAP18 to interact with mSin3...
  34. ncbi The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity
    Ya Li Yao
    Institute of Zoology, Academia Sinica, Taipei 115, Taiwan, Republic of China
    J Biol Chem 278:42560-8. 2003
    ..However, MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA proteins...
  35. ncbi Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma
    Hai Song
    P O Box 35, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    World J Gastroenterol 10:509-13. 2004
    ..To reveal new tumor markers and target genes from differentially expressed genes of primary tumor samples using cDNA microarray...
  36. ncbi MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    Naoyuki Fujita
    Emory University School of Medicine, Department of Pathology, Whitehead Biomedical Research Building, Room 142, 615 Michael Street, Atlanta, GA 30322, USA
    Cell 113:207-19. 2003
    ..These results establish a mechanistic link between estrogen receptor status and invasive growth of breast cancers...
  37. ncbi Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1
    G W Humphrey
    Laboratory of Molecular Growth Regulation, NICHD, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    J Biol Chem 276:6817-24. 2001
    ..Complex cII (15 S) contained >/=15 proteins, including CHD3/4 (Mi-2), Mta-L1, RbAp48/46, and MBD3, characteristic of vertebrate nucleosome-remodeling complexes...
  38. pmc Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte
    D Vermaak
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
    Mol Cell Biol 19:5847-60. 1999
    ..Endogenous Xenopus RPD3 is present in nuclear and cytoplasmic pools, whereas RbAp48 and SIN3 are predominantly nuclear...
  39. ncbi Multiple N-CoR complexes contain distinct histone deacetylases
    P L Jones
    Unit of Molecular Morphogenesis, Laboratory of Molecular Embryology, NICHD, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
    J Biol Chem 276:8807-11. 2001
    ..One complex contains Sin3, Rpd3, and RbAp48; the second complex contains a Sin3-independent histone deacetylase; and the third complex lacks histone ..
  40. pmc Nucleosome binding and histone methyltransferase activity of Drosophila PRC2
    Maxim Nekrasov
    Gene Expression Programme, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 6:348-53. 2005
    ..exists in a multiprotein complex called Polycomb repressive complex 2 (PRC2) that also contains Su(z)12, Esc and Nurf55. Reconstituted recombinant PRC2 methylates nucleosomes in vitro, but recombinant E(z) on its own shows only poor ..
  41. pmc Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners
    Rocio Montes De Oca
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS ONE 4:e7050. 2009
    ..from HeLa cells for seven candidates including Requiem, poly(ADP-ribose) polymerase 1 (PARP1), retinoblastoma binding protein 4 (RBBP4), damage-specific DNA binding protein 1 (DDB1) and DDB2...
  42. ncbi Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation
    Ilmo Leivo
    Department of Pathology, Haartman Institute and Helsinki University Central Hospital, P O Box 21 Haartmaninkatu 3, FIN 00014 University of Helsinki, Helsinki, Finland
    Cancer Genet Cytogenet 156:104-13. 2005
    ..The array results were validated by RT-PCR and immunohistochemistry...
  43. pmc Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft
    B K Kennedy
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 98:8720-5. 2001
    ..In addition to RPD3, repression by pRB in yeast requires MSI1, an ortholog of RbAp48, but not SIN3 or SAP30...
  44. pmc Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis
    Pauline E Jullien
    Chromatin and Reproduction Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Republic of Singapore
    PLoS Biol 6:e194. 2008
    ..we show that in addition to DME, the plant homologs of the human Retinoblastoma (Rb) and its binding partner RbAp48 are required for the activation of the imprinted genes FIS2 and FWA...
  45. pmc Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex
    D A Gdula
    Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255 USA
    Genes Dev 12:3206-16. 1998
    ..Another subunit, NURF-55, is a 55-kD WD repeat protein homologous to the human retinoblastoma-associated protein RbAp48. Here, we report the cloning and characterization of the smallest (38 kD) component of NURF...
  46. pmc Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands
    Naozumi Ishimaru
    Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 Kuramotocho, Tokushima 770 8504, Japan
    Mol Cell Biol 26:2924-35. 2006
    ..Here we show that RbAp48 overexpression induces p53-mediated apoptosis in the exocrine glands caused by estrogen deficiency...
  47. doi An RbAp48-like gene regulates adult stem cells in planarians
    Lucia Bonuccelli
    Dipartimento di Morfologia Umana e Biologia Applicata, Universita di Pisa, Pisa, Italy
    J Cell Sci 123:690-8. 2010
    Retinoblastoma-associated proteins 46 and 48 (RbAp46 and RbAp48) are factors that are components of different chromatin-modelling complexes, such as polycomb repressive complex 2, the activity of which is related to epigenetic gene ..
  48. doi Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations
    Rieko Arakaki
    Department of Oral Molecular Pathology, Institute of Health Bioscencse, The University of Tokushima Graduate School, 3 Kuramotocho, Tokushima 770 8504, Japan
    Immunotherapy 2:339-46. 2010
    ..We found that RbAp48 overexpression induces p53-mediated apoptosis in the exocrine glands depending on estrogen deficiency...
  49. pmc CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1
    S D Johnston
    Department of Genetics, Cell Biology and Development, University of Minnesota, St Paul, Minnesota 55108, USA
    Mol Cell Biol 21:1784-94. 2001
    Cac3p/Msi1p, the Saccharomyces cerevisiae homolog of retinoblastoma-associated protein 48 (RbAp48), is a component of chromatin assembly factor I (CAF-I), a complex that assembles histones H3 and H4 onto replicated DNA...
  50. pmc Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA
    Scott S Terhune
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 6:e1000965. 2010
    ..We propose that pUL29/28 modifies the NuRD complex to stimulate the accumulation of immediate-early RNAs...
  51. pmc The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein
    J K Tyler
    Department of Biology and Center for Molecular Genetics, University of California at San Diego, La Jolla 92093 0347, USA
    Mol Cell Biol 16:6149-59. 1996
    ..The p55 polypeptide comprises seven WD repeat motifs and is homologous to the mammalian RbAp48 protein, which is associated with the HD1 histone deacetylase...
  52. ncbi Purification and properties of the Xenopus Hat1 acetyltransferase: association with the 14-3-3 proteins in the oocyte nucleus
    A Imhof
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 5431, USA
    Biochemistry 38:13085-93. 1999
    ..The holoenzyme contains the catalytic subunit Hat1, the retinoblastoma associated protein RbAp48, and members of the phosphoserine binding family of 14-3-3 proteins...
  53. ncbi E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
    Matthew J Oberley
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    J Biol Chem 278:42466-76. 2003
    ..Specifically, our results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes...
  54. doi Epigenetic silencers are enriched in dormant desert frog muscle
    Nicholas J Hudson
    CSIRO Livestock Industries, Brisbane, QLD, Australia
    J Comp Physiol B 178:729-34. 2008
    ..methyltransferase 1, methyl CpG binding protein 2, chromodomain helicase DNA binding protein 4, histone binding protein rbbp4, histone deacetylase 1 and nuclear receptor co-repressor 2] using qRT-PCR...
  55. pmc A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals
    R A Ach
    Department of Plant and Microbial Biology, University of California, Berkeley 94720 3102, USA
    Plant Cell 9:1595-606. 1997
    ..Two closely related mammalian RB binding proteins, RbAp48 and RbAp46, share sequence homology with the Msi1 protein of yeast...
  56. ncbi Reassembling proteins and chaperones in human nuclear matrix protein fractions
    C Gerner
    Institute of Cancer Research, University of Vienna, Austria
    J Cell Biochem 74:145-51. 1999
    ..They consisted of a protein exhibiting a novel amino acid sequence; of nuclear lamin B2, RbAp46, and RbAp48; and of four as yet unknown proteins...
  57. pmc MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells
    Evan P Kransdorf
    Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, 401 College Street, PO Box 980037, Richmond, VA 23298 0037, USA
    Blood 108:2836-45. 2006
    ..Four components of the MeCP1 transcriptional repression complex were identified: MBD2, RBAP48, HDAC2, and MTA1...
  58. ncbi Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression
    Jason A Beyea
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Dev Dyn 234:404-12. 2005
    ..of mouse GH, as were the concentrations of beta subunit G-protein calponin 2, beta-5 tubulin, retinoblastoma binding protein 4, and fetuin A...
  59. pmc Chaperone-mediated assembly of centromeric chromatin in vitro
    Takehito Furuyama
    Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 103:6172-7. 2006
    ..led to purification of the same complex, which consists of CenH3, histone H4, and a single protein chaperone, RbAp48, a highly abundant component of various chromatin assembly, remodeling, and modification complexes...
  60. ncbi AtMSI4 and RbAp48 WD-40 repeat proteins bind metal ions
    A L Kenzior
    Department of Biochemistry, University of Missouri Columbia, 65211, USA
    FEBS Lett 440:425-9. 1998
    The mammalian RbAp48 protein is the most extensively studied member of the conserved family of Msi1-like WD-40 repeat proteins, which are components of complexes involved in the assembly and modification of chromatin...
  61. ncbi Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p
    Michael J Mallory
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 278:44727-34. 2003
    Ume1p is a member of a conserved protein family including RbAp48 that associates with histone deacetylases...
  62. ncbi Salivary gland and autoimmunity
    Yoshio Hayashi
    Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 56:185-91. 2009
    ..We found that retinoblastoma-associated protein RbAp48 overexpression induces p53-mediated apoptosis in the salivary glands caused by estrogen deficiency...
  63. pmc Role of hPHF1 in H3K27 methylation and Hox gene silencing
    Ru Cao
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cell Biol 28:1862-72. 2008
    ..The EED-EZH2 complex, containing the core subunits EZH2, EED, SUZ12, and RbAp48, functions as a histone H3K27-specific methyltransferase...
  64. ncbi Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer
    Junya Fukuoka
    Laboratory of Population Genetics, Biometric Research Branch, Center for Bioinformatics, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 10:4314-24. 2004
    ..mSin3A, HDAC1, and HAT1 clustered together, whereas nuclear signals of BRG1, BAF155, HDAC2, BAF170, and RbAP48 formed a second cluster...
  65. ncbi lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
    X Lu
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 95:981-91. 1998
    ..lin-53 encodes a protein similar to RbAp48, a mammalian protein that binds Rb...
  66. ncbi The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism
    M R Parthun
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:85-94. 1996
    ..Hat2p, which is required for high affinity binding of the acetyltransferase to histone H4, is highly related to Rbap48, which is a subunit of the chromatin assembly factor, CAF-1, and copurifies with the human histone deacetylase HD1...
  67. ncbi Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation
    Michaela Merkerova
    Institute of Hematology and Blood Transfusion, Department of Molecular Genetics, Prague, Unemocnice 1, 128 20 Prague 2, Czech Republic
    Leuk Lymphoma 48:793-801. 2007
    ..Despite the fact that Bmi-1 deregulation occurs in CML and its expression is connected to several oncogenic processes, Bmi-1 seems to play a secondary role in CML transformation...
  68. ncbi LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes
    Fabienne Schmit
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Cell Cycle 6:1903-13. 2007
    ..The LINC core complex consists of at least five subunits including the chromatin-associated LIN-9 and RbAp48 proteins. LINC dynamically associates with pocket proteins, E2F and B-MYB during the cell cycle...
  69. pmc CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene
    Acharawan Topark-Ngarm
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Biol Chem 281:32272-83. 2006
    ..CTIP2 was found to associate with the NuRD complex through direct interaction with both RbAp46 and RbAp48, and components of the NuRD complex were found to be recruited to an artificial promoter template in a CTIP2-..
  70. ncbi Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres
    Takeshi Hayashi
    Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, 606 8502, Japan
    Cell 118:715-29. 2004
    ..In contrast, Mis15, Mis16 (strong similarity with human RbAp48 and RbAp46), Mis17, and Mis18 are all part of the CENP-A recruitment pathway...
  71. ncbi Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
    Larisa Litovchick
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 26:539-51. 2007
    ..This work reveals an evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence...
  72. pmc Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities
    So Yeon Kwon
    Institute of Biomedical Research, University of Birmingham, Edgbaston, United Kingdom
    PLoS Genet 5:e1000574. 2009
    ..This truncated NURF301 isoform assembles a complex containing ISWI, NURF55, and NURF38, indicating that a second class of NURF remodeling complex, deficient in H3K4me3 and H4K16Ac ..
  73. doi Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex
    Hirak Kumar Barman
    Section of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 8200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 373:624-30. 2008
    ..Here, using chicken DT 40 cytosolic extracts, we found that histones H3/H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, were associated with Hat1...
  74. pmc Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif
    A Melendez
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 155:1127-37. 2000
    ..One group of SynMuv genes, termed class B, includes genes encoding proteins related to the tumor suppressor Rb and RbAp48, a protein that binds Rb. Here, we provide genetic evidence that lin-13 behaves as a class B SynMuv gene...
  75. ncbi [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]
    I Garajova
    klinika komplexní onkologické péce, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:381-6. 2008
    ..It is based on fluoropyrimidines (5-fluorouracil, capecitabine) with concurrent radiotherapy. The aim of the study was to evaluate the capability of gene expression method to identify nonresponders (NR) pretherapeutically...
  76. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  77. ncbi A comprehensive screen for chicken proteins that interact with proteins unique to virulent strains of Marek's disease virus
    M Niikura
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Poult Sci 83:1117-23. 2004
    ..Taken together, our results indicate that integrated genomic methods provide a powerful strategy to gain insights on complex biological processes and yield a manageable number of genes and pathways for further characterization...
  78. ncbi Routine expression profiling of microarray gene signatures in acute leukaemia by real-time PCR of human bone marrow
    Ebrahim Sakhinia
    Division of Laboratory and Regenerative Medicine, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Br J Haematol 130:233-48. 2005
    ..01) were increased in AML in the CD34(+) and CD34(-) fractions, respectively. c-MYB, hSNF2, RBAP48, HKRT-1, LYN, CD33, Adipsin and HOXA9 were increased in AML compared with remission AML, indicating an ability to ..
  79. pmc Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes
    Xingguo Li
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Blood 118:1386-94. 2011
    ..Therefore, our data reveal a synergistic role of hSET1 and NURF in regulating the USF-bound barrier insulator to prevent erythroid genes from encroachment of heterochromatin...
  80. pmc Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1
    Wei Zhang
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Nat Struct Mol Biol 20:29-35. 2013
    ..end we have studied the interaction of the histone H3-H4 complex with the human retinoblastoma-associated protein RbAp48 and their exchange with a second histone chaperone, anti-silencing function protein 1 (ASF1)...
  81. doi Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A
    Magdalena Karolczak-Bayatti
    Institute of Cellular Medicine, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne, England, UK
    Reprod Sci 19:1323-31. 2012
    ..study, we show that myometrial transcriptional complexes consisting of Sp1, Sp3, histone deacetylase (HDAC)1/2, RbAp48, and mSin3A are recruited to 4 out of the 6 Sp1-4 sites within the Gαs promoter...
  82. ncbi Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  83. pmc On WD40 proteins: propelling our knowledge of transcriptional control?
    Valentina Migliori
    Institute of Molecular and Cell Biology, Singapore, Singapore
    Epigenetics 7:815-22. 2012
    ..Finally, we will summarize recent literature elucidating how other WD40 proteins such as NURF55, EED and LRWD1 recognize methylated histone tails, highlighting similarities and differences among them.
  84. pmc The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression
    Subhashini Sadasivam
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 26:474-89. 2012
    ..Our results reveal a novel role for the MuvB complex in recruiting B-Myb and FoxM1 to promote late cell cycle gene expression and in regulating cell cycle gene expression from quiescence through mitosis...
  85. pmc Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply
    Katrine Ask
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    EMBO J 31:2013-23. 2012
    ..This function is compromised by two CDAI mutations that impair complex formation with Asf1, providing insight into the molecular basis for CDAI disease...
  86. pmc Jarid2 and PRC2, partners in regulating gene expression
    Gang Li
    Howard Hughes Medical Institute, New York University Medical School, New York, New York 10016, USA
    Genes Dev 24:368-80. 2010
    ..In addition to the well-documented defects in embryonic viability upon down-regulation of Jarid2, ES cell differentiation is impaired, as is Oct4 silencing...
  87. pmc Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    Syuzo Kaneko
    Howard Hughes Medical Institute, New York University School of Medicine, New York, 10016, USA
    Genes Dev 24:2615-20. 2010
    ..A phospho-mimic at residue 345 increased HOTAIR ncRNA binding to Ezh2, while the phospho-mimic at residue 487 was ineffectual. An Ezh2 domain comprising T345 was found to be important for binding to HOTAIR and the 5' end of Xist...
  88. doi Analysis of interaction partners of H4 histone by a new proteomics approach
    Evelyne Saade
    Institut Gustave Roussy, Villejuif, France
    Proteomics 9:4934-43. 2009
    ..In particular, we observed different fractionation patterns of HAT1 and RbAp46 proteins as compared with RbAp48 protein, all identified as interaction partners of H4 histone...
  89. pmc Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes
    David Adenuga
    Department of Environmental Medicine, University of Rochester Medical Center, NY 14642, USA
    Arch Biochem Biophys 498:62-73. 2010
    ..Thus, phospho-acetylation of HDAC2 negatively regulates its deacetylase activity which has implications in steroid resistance in chronic inflammatory conditions...
  90. pmc Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells
    Capucine Van Rechem
    CNRS UMR 8161, Institut de Biologie de Lille, Universite Lille Nord de France, Institut Pasteur de Lille, IFR 142, 1 rue Calmette, 59017 Lille Cedex, France
    Mol Cell Biol 30:4045-59. 2010
    ..Our results decipher a mechanistic link between two competitive posttranslational modifications of HIC1 and corepressor recruitment to specific genes, leading to growth control...
  91. doi LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
    Yan Wang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China
    Cell 138:660-72. 2009
    ..By enlisting LSD1, the NuRD complex expands its chromatin remodeling capacity to include ATPase, histone deacetylase, and histone demethylase...
  92. pmc Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex
    Magdalena Banach-Orlowska
    International Institute of Molecular and Cell Biology, Laboratory of Cell Biology, Ks Trojdena 4, 02 109 Warsaw, Poland
    Biochem J 423:389-400. 2009
    ..In a broader sense, these results contribute to an emerging theme of endocytic proteins playing alternative roles in the cell nucleus...
  93. pmc The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression
    Amy L Creekmore
    Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, United States
    Mol Cell Endocrinol 291:79-86. 2008
    ..We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins ..
  94. ncbi Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes
    G Bauw
    Laboratorium voor Genetica, Rijksuniversiteit Gent, Belgium
    Electrophoresis 11:528-36. 1990
    ..This offers a unique opportunity to link information contained in protein databases with known or forthcoming DNA sequence data...
  95. doi Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes
    Hyo Kyoung Choi
    Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Mol Endocrinol 22:1093-104. 2008
    ..Finally, we observed that the WD-40 proteins RbAp46 and RbAp48 of the sin3A corepressor complex failed to dimerize...
  96. pmc Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA
    Bone 43:511-20. 2008
    ..and proteoglycan link protein 1 (Hapln1), hemoglobin beta-2 subunit, type I procollagen (Col1a2), retinoblastoma binding protein 4 (LOC685491), Sparc-related modular calcium binding 2 (Smoc2), and calpastatin (Cast)...
  97. pmc Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46
    Natalia V Murzina
    Department of Biochemistry, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Structure 16:1077-85. 2008
    RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure...
  98. pmc A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function
    Shinichiro Takezawa
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    EMBO J 26:764-74. 2007
    ....
  99. pmc Identification and functional characterization of the p66/p68 components of the MeCP1 complex
    Qin Feng
    Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Mol Cell Biol 22:536-46. 2002
    ..The identification and characterization of all the MeCP1 components set the stage for reconstitution of the MeCP1 complex...
  100. pmc Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)
    A Kuzmichev
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:835-48. 2002
    ..previously found that a human Sin3-HDAC complex includes HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, and two novel polypeptides SAP30 and SAP18...
  101. ncbi Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70
    Colin A Johnson
    Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    J Biol Chem 277:9590-7. 2002
    ..We suggest that Hsp chaperone proteins enhance the deacetylase activity of HDAC complexes by ATP-dependent manipulation of protein substrates...

Research Grants20

  1. ROLE OF CHROMATIN REMODELERS IN B AND T CELL DEVELOPMENT
    SAID SIF; Fiscal Year: 2004
    ..abstract_text> ..
  2. Prediction of Radiation Response With A Novel Classifier
    Javier Torres Roca; Fiscal Year: 2007
    ..Finally, we have hypothesized that RbAp48, one of the genes identified in our analysis, plays a direct role in determining radiation phenotype...
  3. RB-Related Proteins in SV40T Transformation
    James A DeCaprio; Fiscal Year: 2010
    ..We will test if two protein complexes termed DREAM and NuRD that bind to p130 and p107 are also inactivated by T Ag and determine if DREAM and NuRD also serve as tumor suppressors. ..
  4. Transcriptional regulation of TAL1/SCL in normal and malignant hematopoiesis
    Suming Huang; Fiscal Year: 2010
    ..These studies will provide novel insights into TAL1 function in the regulation of blood cell development and will help to design new therapeutic approaches to treat leukemia. ..
  5. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2009
    ..The studies will provide a novel insight into USF function in the regulation of developmental stage-specific globin gene expression and will lead to novel strategies for the molecular therapy of anemia. ..
  6. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2010
    ..The studies will provide a novel insight into USF function in the regulation of developmental stage-specific globin gene expression and will lead to novel strategies for the molecular therapy of anemia. ..
  7. Transcriptional regulation of TAL1/SCL in normal and malignant hematopoiesis
    Suming Huang; Fiscal Year: 2009
    ..These studies will provide novel insights into TAL1 function in the regulation of blood cell development and will help to design new therapeutic approaches to treat leukemia. ..
  8. Transcriptional regulation of TAL1/SCL in normal and malignant hematopoiesis
    Suming Huang; Fiscal Year: 2009
    ..These studies will provide novel insights into TAL1 function in the regulation of blood cell development and will help to design new therapeutic approaches to treat leukemia. ..
  9. A role for the CdLS gene NIPBL in HP1 gene silencing
    MARK LECHNER; Fiscal Year: 2007
    ....
  10. Effects of human SWI/SNF-associated PRMT5 on lymphomagenesis
    SAID SIF; Fiscal Year: 2007
    ....
  11. Effects of human SWI/SNF-associated PRMT5 on lymphomagenesis
    SAID SIF; Fiscal Year: 2011
    ..abstract_text> ..