Rb

Summary

Gene Symbol: Rb
Description: RB transcriptional corepressor 1
Alias: OSRC, PPP1R130, p105-Rb, pRb, pp110, retinoblastoma-associated protein, GOS563 exon 17 substitution mutation causes premature stop, exon 17 tumor GOS561 substitution mutation causes premature stop, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, retinoblastoma 1, retinoblastoma suspectibility protein
Species: human
Products:     Rb

Top Publications

  1. Berge E, Knappskog S, Geisler S, Staalesen V, Pacal M, Børresen Dale A, et al. Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers. Mol Cancer. 2010;9:173 pubmed publisher
    The tumor suppressor pRb plays a key role regulating cell cycle arrest, and disturbances in the RB1 gene have been reported in different cancer forms...
  2. Dommering C, Marees T, van der Hout A, Imhof S, Meijers Heijboer H, Ringens P, et al. RB1 mutations and second primary malignancies after hereditary retinoblastoma. Fam Cancer. 2012;11:225-33 pubmed publisher
    ..Our findings suggest a genotype-phenotype correlation for second primary cancers of retinoblastoma survivors and may impact on long-term surveillance protocols of patients with hereditary retinoblastoma, if confirmed by future studies...
  3. Macias M, Dean M, Atkinson A, Jiménez Morales S, García Vazquez F, Saldaña Alvarez Y, et al. Spectrum of RB1 gene mutations and loss of heterozygosity in Mexican patients with retinoblastoma: identification of six novel mutations. Cancer Biomark. 2008;4:93-9 pubmed
  4. Alessio N, Bohn W, Rauchberger V, Rizzolio F, Cipollaro M, Rosemann M, et al. Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells. Cell Mol Life Sci. 2013;70:1637-51 pubmed publisher
    ..In summary, our data show evidence that the silencing of the expression of RB1 or RB2/P130 is not compensated by other gene family members, and this profoundly affects MSC functions. ..
  5. Abouzeid H, Schorderet D, Balmer A, Munier F. Germline mutations in retinoma patients: relevance to low-penetrance and low-expressivity molecular basis. Mol Vis. 2009;15:771-7 pubmed
    ..who have retinoma, which is a benign tumor resembling the post irradiation regression pattern of retinoblastoma (RB)...
  6. Liu X, Marmorstein R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 2007;21:2711-6 pubmed
    ..mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor...
  7. Chau C, Deng Z, Kang H, Lieberman P. Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol. 2008;82:3428-37 pubmed publisher
    ..Several previously unknown factors were identified, including the cell cycle regulatory proteins E2F1 and Rb. E2F1 bound to a specific site in Cp located in the core Cp region 3' of the known EBNA2-responsive RBP-Jk (CSL, ..
  8. Du W, Wu J, Walsh E, Zhang Y, Chen C, Xiao Z. Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3. J Biol Chem. 2009;284:26315-21 pubmed publisher
    The retinoblastoma protein (Rb) plays a pivotal role in regulating cell proliferation and apoptosis...
  9. Haferkamp S, Becker T, Scurr L, Kefford R, Rizos H. p16INK4a-induced senescence is disabled by melanoma-associated mutations. Aging Cell. 2008;7:733-45 pubmed
    The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression...

More Information

Publications67

  1. Li C, Nyman J, Braithwaite A, Eccles M. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011;30:4824-34 pubmed publisher
    The retinoblastoma protein (RB)-E2F1 pathway has a central role in regulating the cell cycle...
  2. Mizuarai S, Machida T, Kobayashi T, Komatani H, Itadani H, Kotani H. Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples. Mol Cancer. 2011;10:31 pubmed publisher
  3. Nijwening J, Geutjes E, Bernards R, Beijersbergen R. The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS ONE. 2011;6:e25235 pubmed publisher
    Senescence is a robust cell cycle arrest controlled by the p53 and Rb pathways that acts as an important barrier to tumorigenesis...
  4. Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein Szanto A, et al. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012;19:1152-61 pubmed publisher
    Inactivation of the retinoblastoma protein (pRb) by phosphorylation triggers uncontrolled cell proliferation...
  5. Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, et al. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009;15:184-94 pubmed publisher
    The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors...
  6. Uchida C. The retinoblastoma protein: functions beyond the G1-S regulator. Curr Drug Targets. 2012;13:1622-32 pubmed
    Retinoblastoma protein (pRB) is functionally inactivated in a large number of tumors including retinoblastoma, osteosarcoma, small-cell lung carcinoma, as well as bladder, breast and prostate cancers...
  7. Delston R, Matatall K, Sun Y, Onken M, Harbour J. p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene. 2011;30:588-99 pubmed publisher
    The retinoblastoma protein (Rb) inhibits both cell division and apoptosis, but the mechanism by which Rb alternatively regulates these divergent outcomes remains poorly understood...
  8. Pickard A, Cichon A, Barry A, Kieran D, Patel D, Hamilton P, et al. Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion. EMBO J. 2012;31:3092-103 pubmed publisher
    ..We have observed inactivation of the retinoblastoma protein (Rb), through phosphorylation, in cancer-associated fibroblasts in oro-pharyngeal cancer specimens...
  9. Pradhan M, Ng Y, Strickland A, George P, Raizis A, Warrington J, et al. Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clin Exp Ophthalmol. 2010;38:231-6 pubmed publisher
    ..Retinoblastoma (MIM +180 200) is a malignant neoplasm affecting embryonal retina, associated with mutations in the RB1 gene. This paper investigates the results of RB1 testing in retinoblastoma management in a tertiary referral centre...
  10. Kiss A, Lontay B, Bécsi B, Markasz L, Olah E, Gergely P, et al. Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A. Cell Signal. 2008;20:2059-70 pubmed publisher
    Reversible phosphorylation of the retinoblastoma protein (pRb) is an important regulatory mechanism in cell cycle progression...
  11. Pickard A, Wong P, McCance D. Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci. 2010;123:3718-26 pubmed publisher
    Although the retinoblastoma protein (Rb) functions as a checkpoint in the cell cycle, it also regulates differentiation...
  12. He M, An Y, Li G, Qian J, Gao Y. [Characteristics of RB1 gene mutations in Chinese patients with retinoblastoma]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013;30:509-12 pubmed publisher
    ..Screening for RB1 gene mutations in patients with bilateral or unilateral retinoblastoma can help to identify heritable mutations and provide important clues for genetic counseling and clinical management. ..
  13. Ayari Jeridi H, Bouguila H, Ansperger Rescher B, Baroudi O, Mdimegh I, Omran I, et al. Genetic testing in Tunisian families with heritable retinoblastoma using a low cost approach permits accurate risk prediction in relatives and reveals incomplete penetrance in adults. Exp Eye Res. 2014;124:48-55 pubmed publisher
    ..Our results point out that genetic testing is needed to reveal or exclude incomplete penetrance specifically in parents of patients with sporadic disease. ..
  14. Chemes L, Sánchez I, Smal C, de Prat Gay G. Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7. FEBS J. 2010;277:973-88 pubmed publisher
    ..The retinoblastoma (Rb) protein controls the G1/S checkpoint, and is targeted by several viral oncoproteins, among these the E7 protein ..
  15. Parsam V, Kannabiran C, Honavar S, Vemuganti G, Ali M. A comprehensive, sensitive and economical approach for the detection of mutations in the RB1 gene in retinoblastoma. J Genet. 2009;88:517-27 pubmed
    Retinoblastoma (Rb) is the most common primary intraocular malignancy in children. It is brought about by the mutational inactivation of both alleles of RB1 gene in the developing retina...
  16. Manning A, Longworth M, Dyson N. Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 2010;24:1364-76 pubmed publisher
    ..By monitoring chromosome segregation, we show that depletion of the retinoblastoma protein (pRB) causes rates of missegregation comparable with those seen in CIN tumor cells...
  17. Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 2010;9:59 pubmed publisher
    ..Inhibition of KDM5B may affect apoptosis and reduce growth of cancer cells. Further studies will explore the pan-cancer therapeutic potential of KDM5B inhibition. ..
  18. Burke J, Hura G, Rubin S. Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev. 2012;26:1156-66 pubmed publisher
    Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives cell proliferation through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins...
  19. Ahani A, Behnam B, Khorshid H, Akbari M. RB1 gene mutations in Iranian patients with retinoblastoma: report of four novel mutations. Cancer Genet. 2011;204:316-22 pubmed publisher
    ..Molecular genetic testing of retinoblastoma patients greatly affects the genetic counseling of the families involved, as well as the management of the disease in patients and at-risk relatives...
  20. Morales L, Peña K, Kim D, Lieman J. SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis. Cell Mol Biol Lett. 2012;17:422-32 pubmed publisher
    Apoptosis is intimately connected to cell cycle regulation via the Retinoblastoma (Rb)-E2F pathway and thereby serves an essential role in tumor suppression by eliminating aberrant hyperproliferative cells...
  21. Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, et al. Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras. Cell Cycle. 2008;7:2384-91 pubmed
    ..a discordant phenotype in the tumor cells with induction of p16 and loss of cyclin D1 consistent with a null RB status combined with homozygous expression of mutant ras which had not been reported previously for RB (-) small-..
  22. Rushlow D, Mol B, Kennett J, Yee S, Pajovic S, Thériault B, et al. Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. Lancet Oncol. 2013;14:327-34 pubmed publisher
  23. Dimaras H, Khetan V, Halliday W, Orlic M, Prigoda N, Piovesan B, et al. Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma. Hum Mol Genet. 2008;17:1363-72 pubmed publisher
    ..However, stable retinoma is rarely clinically observed because progressive genomic instability commonly leads to highly proliferative retinoblastoma. ..
  24. Choi J, Curtis S, Roy D, Flesken Nikitin A, Nikitin A. Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol. 2010;177:2645-58 pubmed publisher
    ..Because mutations in both the P53 and RB tumor suppressor genes are frequent in STS in humans, we inactivated these genes by Cre-loxP-mediated recombination ..
  25. Stefansson O, Jonasson J, Olafsdottir K, Hilmarsdottir H, Olafsdottir G, Esteller M, et al. CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer. Epigenetics. 2011;6:638-49 pubmed publisher
    ..Expression analysis was performed on TMAs by immunohistochemistry (IHC) for BRCA1, pRb, p16, p53, PTEN, ER, PR, HER2, CK5/6, EGFR, MUC1 and Ki-67...
  26. Jiao W, Lin H, Datta J, Braunschweig T, Chung J, Hewitt S, et al. Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation. Oncogene. 2008;27:3156-64 pubmed
    Inactivation of the retinoblastoma (RB) tumor suppressor pathway, via elevated cyclin-dependent kinase (CDK) activity, is observed in majority of human cancers...
  27. Chicas A, Kapoor A, Wang X, Aksoy O, Evertts A, Zhang M, et al. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proc Natl Acad Sci U S A. 2012;109:8971-6 pubmed publisher
    ..Therefore, we link the Jarid1a and Jarid1b demethylases to a tumor-suppressor network controlling cellular senescence. ..
  28. Liao C, Tsai C, Chang W, Lee W, Wang J. RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. J Biol Chem. 2010;285:33134-43 pubmed publisher
    b>RB plays an essential role in DNA damage-induced growth arrest and regulates the expression of several factors essential for DNA repair machinery...
  29. Derenzini M, Donati G, Mazzini G, Montanaro L, Vici M, Ceccarelli C, et al. Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure. Clin Cancer Res. 2008;14:2199-209 pubmed publisher
    ..RB protein (pRB) expression was prospectively evaluated by immunocytochemistry in 518 consecutive patients and its predictive value ..
  30. Morris E, Ji J, Yang F, Di Stefano L, Herr A, Moon N, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008;455:552-6 pubmed publisher
    ..or apoptosis when activated, and is a key downstream target of the retinoblastoma tumour suppressor protein (pRB)...
  31. Trere D, Brighenti E, Donati G, Ceccarelli C, Santini D, Taffurelli M, et al. High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy. Ann Oncol. 2009;20:1818-23 pubmed publisher
    ..Since the retinoblastoma protein (pRb) loss confers a high sensitivity to chemotherapy regimens, we evaluated the prevalence of pRb loss in TNBCs and its ..
  32. Ertel A, Dean J, Rui H, Liu C, Witkiewicz A, Knudsen K, et al. RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response. Cell Cycle. 2010;9:4153-63 pubmed
    In breast cancer, inactivation of the RB tumor suppressor gene is believed to occur via multiple mechanisms to facilitate tumorigenesis...
  33. Rivadeneira D, Mayhew C, Thangavel C, Sotillo E, Reed C, Grana X, et al. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 2010;138:1920-30 pubmed publisher
    ..The retinoblastoma tumor suppressor (RB) is functionally inactivated at relatively high frequency in hepatocellular carcinoma and hepatoma cell lines...
  34. Hung C, Lin S, Lee C, Chen C, Lin S, Chao M, et al. Low penetrance of retinoblastoma for p.V654L mutation of the RB1 gene. BMC Med Genet. 2011;12:76 pubmed publisher
    ..In germline retinoblastoma, mutations in the RB1 gene predispose individuals to increased cancer risks during development. These mutations segregate as autosomal dominant traits with high penetrance (90%)...
  35. Viatour P, Ehmer U, Saddic L, Dorrell C, Andersen J, Lin C, et al. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011;208:1963-76 pubmed publisher
    ..Evidence indicates that the retinoblastoma (RB) pathway is functionally inactivated in most cases of HCC by genetic, epigenetic, and/or viral mechanisms...
  36. Amato A, Lentini L, Schillaci T, Iovino F, Di Leonardo A. RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation. BMC Cell Biol. 2009;10:79 pubmed publisher
    ..Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability...
  37. Zheng Z, Li L, Liu X, Wang D, Tu B, Wang L, et al. 5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J. 2012;26:449-59 pubmed publisher
    ..Here, we report that the pRb pocket proteins pRb, p107, and p130 were degraded in various cancer cell lines in response to 5-aza-CdR treatment, ..
  38. Barbosa R, Vargas F, Lucena E, Bonvicino C, Seuanez H. Constitutive RB1 mutation in a child conceived by in vitro fertilization: implications for genetic counseling. BMC Med Genet. 2009;10:75 pubmed publisher
    ..In the case of children generated by IVF with oocytes from an anonymous donor which had been stored in a cell repository, this might not be successfully accomplished, making precise diagnosis impracticable for genetic counseling. ..
  39. Hilgendorf K, Leshchiner E, Nedelcu S, Maynard M, Calo E, Ianari A, et al. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev. 2013;27:1003-15 pubmed publisher
    The retinoblastoma protein gene RB-1 is mutated in one-third of human tumors. Its protein product, pRB (retinoblastoma protein), functions as a transcriptional coregulator in many fundamental cellular processes...
  40. Herschkowitz J, He X, Fan C, Perou C. The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. Breast Cancer Res. 2008;10:R75 pubmed publisher
    ..These results suggest that the functional loss of RB1 is common in basal-like tumours, which may play a key role in dictating their aggressive biology and unique therapeutic responses. ..
  41. Zhang K, Nowak I, Rushlow D, Gallie B, Lohmann D. Patterns of missplicing caused by RB1 gene mutations in patients with retinoblastoma and association with phenotypic expression. Hum Mutat. 2008;29:475-84 pubmed publisher
    ..However, the location of a mutation relative to the splice sequence has a strong and consistent influence on phenotypic expression. ..
  42. Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher
    ..were made resistant to TNF-induced apoptosis by a germline mutation blocking caspase cleavage of the retinoblastoma (RB) protein, despite similar frequencies of ?-catenin exon-3 mutations in these two genetic backgrounds...
  43. Abidi O, Knari S, Sefri H, Charif M, Sénéchal A, Hamel C, et al. Mutational analysis of the RB1 gene in Moroccan patients with retinoblastoma. Mol Vis. 2011;17:3541-7 pubmed
    Retinoblastoma (RB), the most common intraocular tumor occurring in infancy and early childhood, is most often related to mutations in the RB1 gene...
  44. Dean J, McClendon A, Stengel K, Knudsen E. Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context. Oncogene. 2010;29:68-80 pubmed publisher
    The retinoblastoma tumor suppressor, RB, is a key regulator of cellular proliferation that is functionally inactivated at high frequency in human cancer...
  45. Burke J, Deshong A, Pelton J, Rubin S. Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J Biol Chem. 2010;285:16286-93 pubmed publisher
    Inactivation of the retinoblastoma protein (Rb) through phosphorylation is an important step in promoting cell cycle progression, and hyperphosphorylated Rb is commonly found in tumors...
  46. Sharma A, Yeow W, Ertel A, Coleman I, Clegg N, Thangavel C, et al. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest. 2010;120:4478-92 pubmed publisher
    Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of RB in tumor progression, however, is poorly defined...
  47. Ferreon J, Martinez Yamout M, Dyson H, Wright P. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A. 2009;106:13260-5 pubmed publisher
    ..that include cyclic-AMP response element binding (CREB) binding protein (CBP)/p300 and the retinoblastoma protein (pRb)...
  48. Chen C, Xu C, Du Z, Chen X, Ren G, Zhang X. A c.1363C>T (p.R455X) nonsense mutation of RB1 gene in a southern Chinese retinoblastoma pedigree. Genet Test Mol Biomarkers. 2010;14:193-6 pubmed publisher
    Retinoblastoma (RB) is the most common malignant intraocular tumor in children. Fifty percent of RB patients are carriers of a predisposing germline mutation with high penetrance. RB1 has been identified as the only pathological gene...
  49. Rushlow D, Piovesan B, Zhang K, Prigoda Lee N, Marchong M, Clark R, et al. Detection of mosaic RB1 mutations in families with retinoblastoma. Hum Mutat. 2009;30:842-51 pubmed publisher
    ..7%) showed somatic mosaicism for the proband's mutation, in contrast to an overall 4.5% somatic mosaicism rate for retinoblastoma probands, suggesting that mosaicism for an RB1 mutation is highly likely to manifest as retinoblastoma. ..
  50. Munro S, Khaire N, Inche A, Carr S, La Thangue N. Lysine methylation regulates the pRb tumour suppressor protein. Oncogene. 2010;29:2357-67 pubmed publisher
    The pRb tumour suppressor protein has a central role in coordinating early cell cycle progression. An important level of control imposed on pRb occurs through post-translational modification, for example, phosphorylation...
  51. Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto T, Chiyoda T, et al. Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem. 2012;287:7896-906 pubmed publisher
    We previously showed that depletion of the retinoblastoma protein (RB) induces down-regulation of the adhesion molecule E-cadherin and thereby triggers the epithelial-mesenchymal transition...
  52. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, et al. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009;20:3305-16 pubmed publisher
    ..As a result, inactivation of Cdh1 leads to activation of the Claspin/Chk1 pathway. Previously, we demonstrated that Rb interacts with Cdh1 to influence its ability to degrade Skp2...
  53. Ottaviani D, Parma D, Giliberto F, Ferrer M, Fandino A, Davila M, et al. Spectrum of RB1 mutations in argentine patients: 20-years experience in the molecular diagnosis of retinoblastoma. Ophthalmic Genet. 2013;34:189-98 pubmed publisher
    ..This study enabled us to obtain information about molecular and genetic features of patients with retinoblastoma in Argentina and correlate them to their phenotype. ..
  54. Berge E, Knappskog S, Lillehaug J, Lønning P. Alterations of the retinoblastoma gene in metastatic breast cancer. Clin Exp Metastasis. 2011;28:319-26 pubmed publisher
    ..While a non-significant association suggesting RB1 alterations to be linked to therapy resistance was observed, our data do not suggest a major role for RB1 alterations explaining acquired drug resistance. ..
  55. Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, et al. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res. 2008;68:5104-12 pubmed publisher
    The retinoblastoma tumor suppressor protein (Rb) is mutated or expressed at very low levels in several tumor types, including retinoblastoma and osteosarcoma, as well as small cell lung, colon, prostate, bladder, and breast carcinomas...
  56. Chano T, Ikebuchi K, Ochi Y, Tameno H, Tomita Y, Jin Y, et al. RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer. PLoS ONE. 2010;5:e11404 pubmed publisher
    ..Evaluation of RB1CC1 expression combined with RB1 and p53 status is expected to provide useful information in clinical practice and future therapeutic strategies in breast cancer. ..
  57. McEvoy J, Nagahawatte P, Finkelstein D, Richards Yutz J, Valentine M, Ma J, et al. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget. 2014;5:438-50 pubmed
    ..In addition, several tumors had complex patterns of structural variations and we identified 3 tumors with chromothripsis at the RB1 locus. This is the first report of chromothripsis as a mechanism for RB1 gene inactivation in cancer. ..
  58. Saddic L, West L, Aslanian A, Yates J, Rubin S, Gozani O, et al. Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem. 2010;285:37733-40 pubmed publisher
    The retinoblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor suppressor...