RASSF5

Summary

Gene Symbol: RASSF5
Description: Ras association domain family member 5
Alias: Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, ras association domain-containing protein 5, Rap1-binding protein, Ras association (RalGDS/AF-6) domain family 5, Ras association (RalGDS/AF-6) domain family member 5, Ras effector-like protein, new ras effector 1, novel Ras effector 1, regulator for cell adhesion and polarization enriched in lymphoid tissue, tumor suppressor RASSF3
Species: human
Products:     RASSF5

Top Publications

  1. Vavvas D, Li X, Avruch J, Zhang X. Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998;273:5439-42 pubmed
    ..We have identified a novel potential Ras effector or target named Nore1. Nore1 has no significant sequence similarity to known mammalian proteins and lacks an identifiable catalytic ..
  2. Chen J, Lui W, Vos M, Clark G, Takahashi M, Schoumans J, et al. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell. 2003;4:405-13 pubmed
    ..1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the ..
  3. Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, Ziegler B, et al. NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma. J Hepatol. 2006;45:81-9 pubmed
    ..We therefore studied the possible inactivation of the putative tumor-suppressors and ras-associating proteins, NORE1A, NORE1B, and RASSF1A in HCCs by mutation or epigenetic gene silencing through promoter-CpG hypermethylation...
  4. Kumari G, Singhal P, Rao M, Mahalingam S. Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals. J Mol Biol. 2007;367:1294-311 pubmed
    ..Here, we show that Ras effector RASSF5/NORE-1 binds strongly to K-Ras but weakly to both N-Ras and H-Ras...
  5. Ortiz Vega S, Khokhlatchev A, Nedwidek M, Zhang X, Dammann R, Pfeifer G, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002;21:1381-90 pubmed
    ..The preferential ability of RASSF1A to heterodimerize with Nore and thereby associate with Ras-like GTPases may be relevant to its putative tumor suppressor function. ..
  6. Djos A, Martinsson T, Kogner P, Caren H. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. Mol Cancer. 2012;11:40 pubmed publisher
    ..In the current study, we found that several of the RASSF family genes (RASSF2, RASSF4, RASSF5, RASSF6, RASSF7, and RASSF10) to various degrees were methylated in neuroblastoma cell lines and primary tumors...
  7. Irimia M, Fraga M, Sanchez Cespedes M, Esteller M. CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. Oncogene. 2004;23:8695-9 pubmed
    ..Inactivation by hypermethylation of a RASSF1A homologue, NORE1A, has recently been observed in human cancers...
  8. Geli J, Kogner P, Lanner F, Natalishvili N, Juhlin C, Kiss N, et al. Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. Int J Cancer. 2008;123:389-394 pubmed publisher
    The putative tumor suppressor NORE1A (RASSF5) is a member of the Ras association domain family and is commonly inactivated in human cancer...
  9. Tommasi S, Dammann R, Jin S, Zhang X, Avruch J, Pfeifer G. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 2002;21:2713-20 pubmed
    ..We have isolated and cloned two human homologues of this gene, RASSF3 and NORE1, located at 12q14.1 and 1q32.1, respectively...

More Information

Publications78

  1. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang X, et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002;12:253-65 pubmed
    ..b>NORE1, a noncatalytic polypeptide, binds specifically to Ras-GTP and to several other Ras-like GTPases...
  2. Calvisi D, Donninger H, Vos M, Birrer M, Gordon L, Leaner V, et al. NORE1A tumor suppressor candidate modulates p21CIP1 via p53. Cancer Res. 2009;69:4629-37 pubmed publisher
    b>NORE1A (RASSF5) is a proapoptotic Ras effector that is frequently inactivated by promoter methylation in human tumors. It is structurally related to the RASSF1A tumor suppressor and is itself implicated as a tumor suppressor...
  3. Schagdarsurengin U, Richter A, Hornung J, Lange C, Steinmann K, Dammann R. Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences. Mol Cancer. 2010;9:264 pubmed publisher
    ..In our study, we analyzed the role of RASSF2, RASSF3, RASSF4, RASSF5A, RASSF5C and RASSF6 and the effectors MST1, MST2 and WW45 in thyroid carcinogenesis...
  4. Macheiner D, Gauglhofer C, Rodgarkia Dara C, Grusch M, Brachner A, Bichler C, et al. NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Res. 2009;69:235-42 pubmed publisher
    Recently, we found epigenetic silencing of the Ras effector genes NORE1B and/or RASSF1A in 97% of the hepatocellular carcinoma (HCC) investigated...
  5. Katagiri K, Imamura M, Kinashi T. Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol. 2006;7:919-28 pubmed
    b>RAPL, a protein that binds the small GTPase Rap1, is required for efficient immune cell trafficking. Here we have identified the kinase Mst1 as a critical effector of RAPL. RAPL regulated the localization and kinase activity of Mst1...
  6. Katagiri K, Maeda A, Shimonaka M, Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol. 2003;4:741-8 pubmed
    ..However, the regulatory mechanism involved is unknown. Here, we identify the Rap1 effector, RAPL, as an essential regulator in this activation...
  7. Vos M, Martinez A, Ellis C, Vallecorsa T, Clark G. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. J Biol Chem. 2003;278:21938-43 pubmed
    ..We now show that the Ras effector Nore1, which is structurally related to RASSF1, can also mediate a Ras-dependent apoptosis...
  8. Moshnikova A, Frye J, Shay J, Minna J, Khokhlatchev A. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. J Biol Chem. 2006;281:8143-52 pubmed
    b>NORE1A is a growth and tumor suppressor that is inactivated in a variety of cancers. NORE1A has been shown to bind to the active Ras oncogene product...
  9. Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, et al. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity. 2010;32:541-56 pubmed publisher
    ..the "inside-out" pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH domain of RapL. TcR induced Rap1-RapL complex formation and LFA-1 binding failed to occur in Skap1(-/-) primary T cells...
  10. Bee C, Moshnikova A, Mellor C, Molloy J, Koryakina Y, Stieglitz B, et al. Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. J Biol Chem. 2010;285:16258-66 pubmed publisher
    b>NORE1A is a Ras-binding protein that belongs to a group of tumor suppressors known as the Ras association domain family...
  11. Kumari G, Singhal P, Suryaraja R, Mahalingam S. Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation. J Mol Biol. 2010;397:89-109 pubmed publisher
    b>RASSF5 is a member of the Ras association domain family, which is known to be involved in cell growth regulation...
  12. Stieglitz B, Bee C, Schwarz D, Yildiz O, Moshnikova A, Khokhlatchev A, et al. Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J. 2008;27:1995-2005 pubmed publisher
    ..b>RASSF5, a member of this family, exists in two splice variants known as NORE1A and RAPL...
  13. Fingert J, Robin A, Stone J, Roos B, Davis L, Scheetz T, et al. Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. Hum Mol Genet. 2011;20:2482-94 pubmed publisher
    ..Real-time PCR studies showed that the genes within this duplication [TBK1 (TANK-binding kinase 1), XPOT, RASSF3 and GNS] are all expressed in the human retina...
  14. Hong M, Zhang Z, Chen Q, Lu Y, Zhang J, Lin C, et al. IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the RAS-RAC1 pathway. Cancer Manag Res. 2019;11:369-378 pubmed publisher
    ..lines; a ChIP assay was used to examine the binding between IRF1 and Ras association domain-containing protein 5 (RASSF5)...
  15. Guo H, Liu H, Wei J, Li Y, Yu H, Guan X, et al. Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck. Eur J Cancer. 2014;50:582-92 pubmed publisher
    b>RASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy...
  16. Raab M, Strebhardt K, Rudd C. Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region. BMC Res Notes. 2018;11:869 pubmed publisher
    ..Previous work by ourselves and others have shown that SKAP1 can directly bind to other adaptors such as ADAP and RapL. However, it has been unclear whether SKAP1 can form homodimers with itself and the regions within SKAP1 that ..
  17. Fukuhara T, Tomiyama T, Yasuda K, Ueda Y, Ozaki Y, Son Y, et al. Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis. Biochem Biophys Res Commun. 2015;463:968-74 pubmed publisher
    ..RASSF5C(RAPL) is an activator of MST1 and it is frequently methylated in some tumors...
  18. Singh M, Pooja D, Kulhari H, Jain S, Sistla R, Chauhan A. Poly (amidoamine) dendrimer-mediated hybrid formulation for combination therapy of ramipril and hydrochlorothiazide. Eur J Pharm Sci. 2017;96:84-92 pubmed publisher
    ..PAMAM dendrimers to be used as drug carriers for combination therapy of an anti-hypertensive drug ramipril (RAPL) and a diuretic hydrochlorothiazide (HCTZ)...
  19. Safavi S, Hansson M, Karlsson K, Biloglav A, Johansson B, Paulsson K. Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia. Haematologica. 2015;100:55-61 pubmed publisher
    ..001), and higher white blood cell counts (P=0.005). In addition, recurrent deletions of RASSF3 and TOX were seen in relapse samples...
  20. Nussinov R, Zhang M, Tsai C, Liao T, Fushman D, Jang H. Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophys Rev. 2018;10:1263-1282 pubmed publisher
    ..the membrane focusing on three representative Ras effectors, Raf protein kinase, PI3Kα lipid kinase, and NORE1A (RASSF5) tumor suppressor, and point to the ramifications to drug discovery...
  21. Kondo N, Ueda Y, Kita T, Ozawa M, Tomiyama T, Yasuda K, et al. NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization. Mol Cell Biol. 2017;37: pubmed publisher
    ..We found that NDR1 kinase, activated by the Rap1 signaling cascade through RAPL and Mst1/Mst2, associated with and recruited kindlin-3 to the IS, which was required for high-affinity LFA-1/ICAM-1 ..
  22. Guo W, Dong Z, Guo Y, Shen S, Guo X, Kuang G, et al. Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma. Mol Carcinog. 2016;55:1655-1666 pubmed publisher
    ..The present study investigated the role and methylation status of RASSF2, RASSF3, RASSF4, and RASSF6 in the pathogenesis and prognosis of GCA...
  23. Nussinov R, Jang H, Tsai C, Liao T, Li S, Fushman D, et al. Intrinsic protein disorder in oncogenic KRAS signaling. Cell Mol Life Sci. 2017;74:3245-3261 pubmed publisher
    ..can promote isoform functional specificity; (3) calmodulin binding and PI3K activation; (4) how Ras activates its RASSF5 cofactor, thereby stimulating signaling of the Hippo pathway and repressing proliferation; and (5) how ..
  24. Nakhaeizadeh H, Amin E, Nakhaei Rad S, Dvorsky R, Ahmadian M. The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLoS ONE. 2016;11:e0167145 pubmed publisher
    ..RRAS1 and RRAS2 to both the RAS binding (RB) domain of CRAF and PI3Kα, and the RAS association (RA) domain of RASSF5, RALGDS and PLCε, respectively, using fluorescence polarization...
  25. Davis L, Meyer K, Schindler E, Beck J, Rudd D, Grundstad A, et al. Copy number variations and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2011;52:7122-33 pubmed publisher
    ..This set included CNVs on 5q23.1 (DMXL1, DTWD2), 20p12 (PAK7), 12q14 (C12orf56, XPOT, TBK1, and RASSF3), 12p13.33 (TULP3), and 10q34.21 (PAX2), among others...
  26. de Kreuk B, Gingras A, Knight J, Liu J, Gingras A, Ginsberg M. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. elife. 2016;5:e11394 pubmed publisher
    ..These studies establish that the binding of HEG1 to Rasip1 mediates Rap1-dependent recruitment of Rasip1 to and stabilization of EC cell-cell junctions. ..
  27. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..wheel running include multiple potassium channel genes, Oprm1, Prkcg, Stxbp1, Crhr1, Gabra3, Slc6a13, Stx1b, Pomc, Rassf5 and Camta2...
  28. Lee I, Lee I, Kim J, Kim J, Chung E, Kim H, et al. NORE1/SAUL1 integrates temperature-dependent defense programs involving SGT1b and PAD4 pathways and leaf senescence in Arabidopsis. Physiol Plant. 2016;158:180-99 pubmed publisher
    ..To dissect the regulatory pathways involved in leaf senescence, we isolated the not oresara1-1 (nore1-1) mutant showing accelerated leaf senescence phenotypes from an EMS-mutagenized Arabidopsis thaliana population...
  29. Su W, Wynne J, Pinheiro E, Strazza M, Mor A, Montenont E, et al. Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood. 2015;126:2695-703 pubmed publisher
    ..Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM)...
  30. Liao T, Jang H, Tsai C, Fushman D, Nussinov R. The dynamic mechanism of RASSF5 and MST kinase activation by Ras. Phys Chem Chem Phys. 2017;19:6470-6480 pubmed publisher
    As a tumor suppressor, RASSF5 (NORE1A) activates MST1/2 thereby modulating the Hippo pathway. Structurally, activation involves RASSF5 and MST1/2 swapping their SARAH domains to form a SARAH heterodimer...
  31. Yohannan D, Krishnapillai R, Suresh R, Ramnarayan S, Peethambaran A, John N. Can the angle between optic nerves indicate whether optic chiasm is prefixed, normofixed or postfixed? An anatomical study with radiologic and neurosurgical implications. Surg Radiol Anat. 2016;38:1175-1181 pubmed
    ..segments of optic nerves (ISON), and to look for any relation between it and the relative anteroposterior location (RAPL) of the optic chiasm (OC)-viz. prefixed, normofixed and postfixed...
  32. Barnoud T, Schmidt M, Donninger H, Clark G. The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence. Cancer Lett. 2017;400:30-36 pubmed publisher
    ..One of these members, NORE1A (RASSF5), may be the missing link between Ras-induced senescence and the regulation of p53 and Rb...
  33. Schmidt M, Calvisi D, Clark G. NORE1A Regulates MDM2 Via ?-TrCP. Cancers (Basel). 2016;8: pubmed publisher
    ..We have recently found that the Ras effector and RASSF (Ras Association Domain Family) family member RASSF5/NORE1A enhances the levels of nuclear p53...
  34. Nussinov R, Tsai C, Jang H. Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?. Semin Cancer Biol. 2019;54:114-120 pubmed publisher
    ..NRas of its oncogenic form? Resolving these cardinal questions, and others, such as how exactly does RASSF5 (NORE1A) act as tumor suppressor, and why Ras isoforms tend to occur in distinct cancer types are crucial for effective ..
  35. Donninger H, Schmidt M, Mezzanotte J, Barnoud T, Clark G. Ras signaling through RASSF proteins. Semin Cell Dev Biol. 2016;58:86-95 pubmed publisher
    ..The frequent epigenetic inactivation of RASSF genes in human tumors disconnects Ras from pro-death signaling systems, enhancing Ras driven transformation and metastasis. The best characterized members are RASSF1A and RASSF5 (NORE1A).
  36. Barnoud T, Donninger H, Clark G. Ras Regulates Rb via NORE1A. J Biol Chem. 2016;291:3114-23 pubmed publisher
    ..We have shown recently that the Ras death effector NORE1A plays a critical role in promoting Ras-induced senescence and connects Ras to the regulation of the p53 tumor ..
  37. Lee D, Park S, Sung K, Park J, Lee S, Park S, et al. Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 2012;13:163-9 pubmed publisher
    The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear...
  38. Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, et al. RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol. 2009;19:279-92 pubmed publisher
    ..Together with deletion or mutation, it may cause a loss of function of tumor suppressor genes. RASSF1A (3p21.3), NORE1A (1q32.1) and BLU (3p21.3) have been shown to be downregulated by methylation in cancer, and PTEN (10q23...
  39. Lim D, Lu Y, Rudd C. Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1. Immunol Lett. 2016;172:40-6 pubmed publisher
    ..the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 ..
  40. Xiong Y, Ye C, Yang N, Li M, Liu H. Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. J Immunol. 2017;199:4142-4154 pubmed publisher
    ..of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion...
  41. Park S, Lee D, Choi C, Ryu S. Induction of apoptosis by NORE1A in a manner dependent on its nuclear export. Biochem Biophys Res Commun. 2008;368:56-61 pubmed publisher
    ..In this study, we showed that NORE1A was exported actively via its nuclear export signal (NES) in the C-terminus (residues 372-379)...
  42. Donninger H, Calvisi D, Barnoud T, Clark J, Schmidt M, Vos M, et al. NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol. 2015;208:777-89 pubmed publisher
    ..Ras senescence pathways remain poorly characterized. NORE1A is a novel Ras effector that serves as a tumor suppressor. It is frequently inactivated in tumors...
  43. Arora P, Basu A, Schmidt M, Clark G, Donninger H, Nichols D, et al. Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication. Hepatology. 2017;65:1462-1477 pubmed publisher
    ..Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tumor suppressor, NORE1A (RASSF5), and promotes its proteosomal degradation...
  44. Schmidt M, Donninger H, Clark G. Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A. J Biol Chem. 2014;289:31102-10 pubmed publisher
    ..However, Ras can also exhibit a potent ability to induce growth arrest and death. NORE1A (RASSF5) is a direct Ras effector that acts as a tumor suppressor by promoting apoptosis and cell cycle arrest...
  45. Ni L, Li S, Yu J, Min J, Brautigam C, Tomchick D, et al. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure. 2013;21:1757-68 pubmed publisher
    ..Here, we report the crystal structures of human Mst2 alone and bound to RASSF5. Mst2 undergoes activation through transautophosphorylation at its activation loop, which requires SARAH-mediated ..
  46. Li T, Yin K, Chen Z, Bao Y, Zhang S. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. 2017;16: pubmed publisher
    Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation...
  47. Zhou X, Yang C, Zhang C, Gao Y, Yuan H, Wang C. RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling. Oncol Rep. 2014;32:1505-12 pubmed publisher
    Ras association (RalGDS/AF-6) domain family member RASSF5 has been implicated in a variety of key biological processes, including cell proliferation, cell cycle regulation and apoptosis...
  48. Praskova M, Khoklatchev A, Ortiz Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J. 2004;381:453-62 pubmed
    ..Co-expression of RASSF1A, RASSF1C, NORE1A and NORE1B with MST1 markedly suppresses MST1(Thr183) phosphorylation in vivo and abolishes the ability of MST1 to undergo Mg-..
  49. Nakamura N, Carney J, Jin L, Kajita S, Pallares J, Zhang H, et al. RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors. Lab Invest. 2005;85:1065-75 pubmed
    We analyzed RASSF1A and NORE1A methylation and BRAF mutation in 89 thyroid tumors, 42 non-neoplastic thyroid tissues and three thyroid tumor cell lines using polymerase chain reaction (PCR), methylation-specific PCR, Western blotting and ..
  50. Kim H, Hwang E, Han Y, Choi S, Lee W, Kim H, et al. Expression, purification, crystallization and preliminary X-ray analysis of the human NORE1 SARAH domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:813-5 pubmed publisher
    b>NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains...
  51. Elmetwali T, Salman A, Palmer D. NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism. Cell Death Dis. 2016;7:e2146 pubmed publisher
    ..In this study, we show that mCD40L but not sCD40L induces NORE1A/Rassf5 expression in an NF?B-dependant mechanism...
  52. Vos M, Clark G. RASSF family proteins and Ras transformation. Methods Enzymol. 2006;407:311-22 pubmed
    ..Thus, RASSF proteins may be described as effector/tumor suppressors, in contrast to traditional Ras effectors such as Raf and PI-3 kinase, which may be considered to be effector/oncoproteins. ..
  53. Suryaraja R, Anitha M, Anbarasu K, Kumari G, Mahalingam S. The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner. Cell Death Dis. 2013;4:e565 pubmed publisher
    Ras association (RalGDS/AF-6) domain family member RASSF5 is a non-enzymatic RAS effector super family protein, known to be involved in cell growth regulation...
  54. Raab M, Smith X, Matthess Y, Strebhardt K, Rudd C. SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1. J Biol Chem. 2011;286:29663-70 pubmed publisher
    ..SKAP1 (SKAP-55) is the upstream regulator needed for TCR-induced RapL-Rap1 complex formation and LFA-1 activation...
  55. Liao T, Tsai C, Jang H, Fushman D, Nussinov R. RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro. Curr Opin Struct Biol. 2016;41:217-224 pubmed publisher
    Is RASSF5 a tumor suppressor or activator? RASSF5 links K-Ras and the Hippo pathway. Hippo's signaling promotes YAP1 phosphorylation and degradation. YAP1 overexpression promotes cancer...
  56. Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, et al. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer. 2011;71:19-27 pubmed publisher
    The candidate tumor suppressor NORE1A is a nucleocytoplasmic shuttling protein, and although a fraction of the NORE1A in cells is localized to their centrosomes, the role of centrosomal NORE1A has not been elucidated...
  57. Miertzschke M, Stanley P, Bunney T, Rodrigues Lima F, Hogg N, Katan M. Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. J Biol Chem. 2007;282:30629-42 pubmed
    ..and random migration of these cells and that an adapter protein from the Ras association domain family (Rassf), RAPL, has a role downstream of Rap2 in addition to its link to Rap1...
  58. Di Gioia S, Bianchi P, Destro A, Grizzi F, Malesci A, Laghi L, et al. Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. BMC Cancer. 2006;6:89 pubmed
    ..RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling...
  59. Guo W, Wang C, Guo Y, Shen S, Guo X, Kuang G, et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. Clin Exp Metastasis. 2015;32:83-98 pubmed publisher
    As a result of alternative splicing and differential promoter usage, RASSF5 exists in at least three isoforms (RASSF5A-RASSF5C), which may play different roles in tumorigenesis...
  60. Lee C, Lee J, Lee M, Jeong S, Ha T, Kang M, et al. Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors. BMC Cancer. 2010;10:577 pubmed publisher
    NORE1 (RASSF5) is a newly described member of the RASSF family with Ras effector function...
  61. Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, et al. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem. 2005;280:5022-31 pubmed
    ..We found that Rap1-associating molecule, RAPL, which belongs to the Ras association domain family (Rassf), localized on microtubules and that activated Rap1 ..
  62. Foukakis T, Au A, Wallin G, Geli J, Forsberg L, Clifton Bligh R, et al. The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion. J Clin Endocrinol Metab. 2006;91:1143-9 pubmed
    The Ras effector NORE1A (RASSF5A) is a putative tumor suppressor and is inactivated in several human cancers. NORE1A has not been studied in thyroid cancer...
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