RASSF3

Summary

Gene Symbol: RASSF3
Description: Ras association domain family member 3
Alias: RASSF5, ras association domain-containing protein 3, Ras association (RalGDS/AF-6) domain family 3, Ras association (RalGDS/AF-6) domain family member 3
Species: human
Products:     RASSF3

Top Publications

  1. Jacquemart I, Springs A, Chen W. Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice. Int J Oncol. 2009;34:517-28 pubmed
    ..A novel gene, the RAS association domain (RalGDS/AF-6) family 3 (Rassf3), which belongs to a family of RAS effectors and tumor suppressor genes, was identified...
  2. Tommasi S, Dammann R, Jin S, Zhang X, Avruch J, Pfeifer G. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 2002;21:2713-20 pubmed
    ..We have isolated and cloned two human homologues of this gene, RASSF3 and NORE1, located at 12q14.1 and 1q32.1, respectively...
  3. Hong M, Zhang Z, Chen Q, Lu Y, Zhang J, Lin C, et al. IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the RAS-RAC1 pathway. Cancer Manag Res. 2019;11:369-378 pubmed publisher
    ..lines; a ChIP assay was used to examine the binding between IRF1 and Ras association domain-containing protein 5 (RASSF5)...
  4. Fingert J, Robin A, Stone J, Roos B, Davis L, Scheetz T, et al. Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. Hum Mol Genet. 2011;20:2482-94 pubmed publisher
    ..Real-time PCR studies showed that the genes within this duplication [TBK1 (TANK-binding kinase 1), XPOT, RASSF3 and GNS] are all expressed in the human retina...
  5. Ni L, Li S, Yu J, Min J, Brautigam C, Tomchick D, et al. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure. 2013;21:1757-68 pubmed publisher
    ..Here, we report the crystal structures of human Mst2 alone and bound to RASSF5. Mst2 undergoes activation through transautophosphorylation at its activation loop, which requires SARAH-mediated ..
  6. Nussinov R, Zhang M, Tsai C, Liao T, Fushman D, Jang H. Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophys Rev. 2018;10:1263-1282 pubmed publisher
    ..the membrane focusing on three representative Ras effectors, Raf protein kinase, PI3Kα lipid kinase, and NORE1A (RASSF5) tumor suppressor, and point to the ramifications to drug discovery...
  7. Guo W, Wang C, Guo Y, Shen S, Guo X, Kuang G, et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. Clin Exp Metastasis. 2015;32:83-98 pubmed publisher
    As a result of alternative splicing and differential promoter usage, RASSF5 exists in at least three isoforms (RASSF5A-RASSF5C), which may play different roles in tumorigenesis...
  8. Zhou X, Yang C, Zhang C, Gao Y, Yuan H, Wang C. RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling. Oncol Rep. 2014;32:1505-12 pubmed publisher
    Ras association (RalGDS/AF-6) domain family member RASSF5 has been implicated in a variety of key biological processes, including cell proliferation, cell cycle regulation and apoptosis...
  9. Schmidt M, Donninger H, Clark G. Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A. J Biol Chem. 2014;289:31102-10 pubmed publisher
    ..However, Ras can also exhibit a potent ability to induce growth arrest and death. NORE1A (RASSF5) is a direct Ras effector that acts as a tumor suppressor by promoting apoptosis and cell cycle arrest...

More Information

Publications32

  1. Safavi S, Hansson M, Karlsson K, Biloglav A, Johansson B, Paulsson K. Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia. Haematologica. 2015;100:55-61 pubmed publisher
    ..001), and higher white blood cell counts (P=0.005). In addition, recurrent deletions of RASSF3 and TOX were seen in relapse samples...
  2. Han L, Dong Z, Wang C, Guo Y, Shen S, Kuang G, et al. Decreased expression and aberrant methylation of RASSF5A correlates with malignant progression of gastric cardia adenocarcinoma. Mol Carcinog. 2015;54:1722-33 pubmed publisher
    Due to alternative splicing and differential promoter usage, RASSF5 exists in at least three isoforms, RASSF5A, RASSF5B, and RASSF5C...
  3. Donninger H, Schmidt M, Mezzanotte J, Barnoud T, Clark G. Ras signaling through RASSF proteins. Semin Cell Dev Biol. 2016;58:86-95 pubmed publisher
    ..The frequent epigenetic inactivation of RASSF genes in human tumors disconnects Ras from pro-death signaling systems, enhancing Ras driven transformation and metastasis. The best characterized members are RASSF1A and RASSF5 (NORE1A).
  4. Guo W, Dong Z, Guo Y, Shen S, Guo X, Kuang G, et al. Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma. Mol Carcinog. 2016;55:1655-1666 pubmed publisher
    ..The present study investigated the role and methylation status of RASSF2, RASSF3, RASSF4, and RASSF6 in the pathogenesis and prognosis of GCA...
  5. Liao T, Jang H, Tsai C, Fushman D, Nussinov R. The dynamic mechanism of RASSF5 and MST kinase activation by Ras. Phys Chem Chem Phys. 2017;19:6470-6480 pubmed publisher
    As a tumor suppressor, RASSF5 (NORE1A) activates MST1/2 thereby modulating the Hippo pathway. Structurally, activation involves RASSF5 and MST1/2 swapping their SARAH domains to form a SARAH heterodimer...
  6. Arora P, Basu A, Schmidt M, Clark G, Donninger H, Nichols D, et al. Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication. Hepatology. 2017;65:1462-1477 pubmed publisher
    ..Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tumor suppressor, NORE1A (RASSF5), and promotes its proteosomal degradation...
  7. Elmetwali T, Salman A, Palmer D. NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism. Cell Death Dis. 2016;7:e2146 pubmed publisher
    ..In this study, we show that mCD40L but not sCD40L induces NORE1A/Rassf5 expression in an NF?B-dependant mechanism...
  8. Schmidt M, Calvisi D, Clark G. NORE1A Regulates MDM2 Via ?-TrCP. Cancers (Basel). 2016;8: pubmed publisher
    ..We have recently found that the Ras effector and RASSF (Ras Association Domain Family) family member RASSF5/NORE1A enhances the levels of nuclear p53...
  9. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..wheel running include multiple potassium channel genes, Oprm1, Prkcg, Stxbp1, Crhr1, Gabra3, Slc6a13, Stx1b, Pomc, Rassf5 and Camta2...
  10. Nussinov R, Tsai C, Jang H. Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?. Semin Cancer Biol. 2019;54:114-120 pubmed publisher
    ..wild-type NRas of its oncogenic form? Resolving these cardinal questions, and others, such as how exactly does RASSF5 (NORE1A) act as tumor suppressor, and why Ras isoforms tend to occur in distinct cancer types are crucial for ..
  11. Li T, Yin K, Chen Z, Bao Y, Zhang S. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. 2017;16: pubmed publisher
    Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation...
  12. Barnoud T, Schmidt M, Donninger H, Clark G. The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence. Cancer Lett. 2017;400:30-36 pubmed publisher
    ..One of these members, NORE1A (RASSF5), may be the missing link between Ras-induced senescence and the regulation of p53 and Rb...
  13. Nussinov R, Jang H, Tsai C, Liao T, Li S, Fushman D, et al. Intrinsic protein disorder in oncogenic KRAS signaling. Cell Mol Life Sci. 2017;74:3245-3261 pubmed publisher
    ..can promote isoform functional specificity; (3) calmodulin binding and PI3K activation; (4) how Ras activates its RASSF5 cofactor, thereby stimulating signaling of the Hippo pathway and repressing proliferation; and (5) how ..
  14. Nakhaeizadeh H, Amin E, Nakhaei Rad S, Dvorsky R, Ahmadian M. The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLoS ONE. 2016;11:e0167145 pubmed publisher
    ..RRAS1 and RRAS2 to both the RAS binding (RB) domain of CRAF and PI3Kα, and the RAS association (RA) domain of RASSF5, RALGDS and PLCε, respectively, using fluorescence polarization...
  15. Davis L, Meyer K, Schindler E, Beck J, Rudd D, Grundstad A, et al. Copy number variations and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2011;52:7122-33 pubmed publisher
    ..This set included CNVs on 5q23.1 (DMXL1, DTWD2), 20p12 (PAK7), 12q14 (C12orf56, XPOT, TBK1, and RASSF3), 12p13.33 (TULP3), and 10q34.21 (PAX2), among others...
  16. Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, et al. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem. 2005;280:5022-31 pubmed
    ..Collectively, the locally activated Rap1 and its association with RAPL controls the directional migration of vascular endothelial cells. ..
  17. Peng H, Liu H, Zhao S, Wu J, Fan J, Liao J. Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas. PLoS ONE. 2013;8:e59024 pubmed publisher
    ..b>RASSF3 was found with frequent methylation of CpG island in its promoter region in somatotroph adenomas but rarely in ..
  18. Schagdarsurengin U, Richter A, Hornung J, Lange C, Steinmann K, Dammann R. Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences. Mol Cancer. 2010;9:264 pubmed publisher
    ..In our study, we analyzed the role of RASSF2, RASSF3, RASSF4, RASSF5A, RASSF5C and RASSF6 and the effectors MST1, MST2 and WW45 in thyroid carcinogenesis...
  19. Li B, Yu C, Xu Y, Liu S, Fan H, Pan W. TET1 inhibits cell proliferation by inducing RASSF5 expression. Oncotarget. 2017;8:86395-86409 pubmed publisher
    ..results of RNA-seq and qRT-PCR analyses identified a tumor suppressor, Ras association domain family member 5 (RASSF5), as the key downstream target of TET1...
  20. Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, et al. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer Res. 2012;72:2901-11 pubmed publisher
    b>RASSF3 is the smallest member of the RASSF family of proteins that function as tumor suppressors. Unlike other members of this important family, the mechanisms through which RASSF3 suppresses tumor formation remain unknown...
  21. Guo H, Liu H, Wei J, Li Y, Yu H, Guan X, et al. Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck. Eur J Cancer. 2014;50:582-92 pubmed publisher
    b>RASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy...
  22. Liao T, Tsai C, Jang H, Fushman D, Nussinov R. RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro. Curr Opin Struct Biol. 2016;41:217-224 pubmed publisher
    Is RASSF5 a tumor suppressor or activator? RASSF5 links K-Ras and the Hippo pathway. Hippo's signaling promotes YAP1 phosphorylation and degradation. YAP1 overexpression promotes cancer...
  23. Fukatsu A, Ishiguro F, Tanaka I, Kudo T, Nakagawa K, Shinjo K, et al. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung Cancer. 2014;83:23-9 pubmed publisher
    ..Ten RASSF homologues comprise this family, and each member is considered a tumor suppressor. RASSF3 is one of the RASSF family members, but its function has not yet been clarified...