RASSF1A

Summary

Gene Symbol: RASSF1A
Description: Ras association domain family member 1
Alias: 123F2, NORE2A, RASSF1A, RDA32, REH3P21, ras association domain-containing protein 1, Ras association (RalGDS/AF-6) domain family member 1, WUGSC:H_LUCA12.5, cardiac-specific ras association domain family 1 protein, pancreas-specific ras association domain family 1 protein, tumor suppressor protein RDA32
Species: human
Products:     RASSF1A

Top Publications

  1. Wang J, Lee J, Wang L, Liu D, Lu C, Fan Y, et al. Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer. Clin Cancer Res. 2004;10:6119-25 pubmed
    The p16INK4a and RASSF1A are tumor suppressor genes frequently inactivated by de novo promoter hypermethylation in non-small cell lung cancer...
  2. Rong R, Jiang L, Sheikh M, Huang Y. Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. Oncogene. 2007;26:7700-8 pubmed
    b>RASSF1A (RAS-association domain family 1, isoform A) is a newer tumor suppressor that binds to and stabilizes microtubules as well as induces M-phase cell cycle arrest...
  3. Yanagawa N, Tamura G, Oizumi H, Kanauchi N, Endoh M, Sadahiro M, et al. Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer. 2007;58:131-8 pubmed
    ..after a surgical resection, we studied methylation in 10 genes (DAPK, FHIT, H-cadherin, MGMT, p14, p16, RAR-beta, RASSF1A, RUNX3, and TIMP-3) in 101 NSCLC cases by methylation-specific PCR (MSP)...
  4. Peters I, Rehmet K, Wilke N, Kuczyk M, Hennenlotter J, Eilers T, et al. RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis. Mol Cancer. 2007;6:49 pubmed
    Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result of promoter hypermethylation...
  5. Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, et al. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res. 2002;8:2362-8 pubmed
    Chromosome 3p is deleted frequently in various types of human cancers, including lung cancer. Recently, the RASSF1A gene was isolated from the 3p21...
  6. Wang J, Wang B, Chen X, Bi J. The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis. Carcinogenesis. 2011;32:411-6 pubmed publisher
    Inactivation of the tumor suppressor gene RASSF1A through methylation of the CpG islands within its promoter region as a prognostic factor for survival in non-small cell lung carcinoma (NSCLC) remains controversial...
  7. Dallol A, Agathanggelou A, Fenton S, Ahmed Choudhury J, Hesson L, Vos M, et al. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Res. 2004;64:4112-6 pubmed
    The candidate tumor suppressor gene RASSF1A is inactivated in many types of adult and childhood cancers. However, the mechanisms by which RASSF1A exerts its tumor suppressive functions have yet to be elucidated...
  8. Song M, Chang J, Song S, Yang T, Lee H, Lim D. The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem. 2005;280:3920-7 pubmed
    The protein RAS association domain family protein 1A (RASSF1A), which is encoded by a gene that is frequently silenced in many types of sporadic tumor, functions in mitosis as a regulator of the anaphase-promoting complex (APC)...
  9. Li Y, Wei Q, Cao F, Cao X. Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. Oncol Rep. 2008;19:1149-53 pubmed
    The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation...

More Information

Publications110 found, 100 shown here

  1. Qian Z, Sano T, Yoshimoto K, Yamada S, Ishizuka A, Mizusawa N, et al. Inactivation of RASSF1A tumor suppressor gene by aberrant promoter hypermethylation in human pituitary adenomas. Lab Invest. 2005;85:464-73 pubmed
    ..The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor locus at 3p21...
  2. Shen W, Dai D, Teng Y, Liu H. [5-Aza-CdR regulates the expression of RASSF1A gene in human gastric cancer cell line and inhibits the growth of cells]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:57-60 pubmed
    ..of demethylating agent 5-Aza-CdR (5-aza-2'- deoxycytidine) on demethylation and transcription-regulating of RASSF1A gene in gastric cancer cell SGC7901 in vitro, as well as on the growth inhibition of cells...
  3. van Engeland M, Roemen G, Brink M, Pachen M, Weijenberg M, De Bruine A, et al. K-ras mutations and RASSF1A promoter methylation in colorectal cancer. Oncogene. 2002;21:3792-5 pubmed
    ..by either genetic activation of the K-ras oncogene or epigenetic silencing of the putative tumor suppressor gene RASSF1A. Paraffin embedded tumor tissue samples from 222 sporadic CRC patients were analysed for K-ras codon 12 and codon ..
  4. Chow L, Lo K, Kwong J, To K, Tsang K, Lam C, et al. RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma. Int J Cancer. 2004;109:839-47 pubmed
    ..3. We have reported recently that RASSF1A gene, located on a 120-kb minimal deletion region on 3p21...
  5. Hamilton G, Yee K, Scrace S, O Neill E. ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol. 2009;19:2020-5 pubmed publisher
    ..The epigenetic-driven loss of RASSF1A protein expression is observed more often in tumors of higher grade and correlates with a decreased ..
  6. Strunnikova M, Schagdarsurengin U, Kehlen A, Garbe J, Stampfer M, Dammann R. Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol. 2005;25:3923-33 pubmed
    Epigenetic inactivation of the RASSF1A tumor suppressor by CpG island methylation was frequently detected in cancer. However, the mechanisms of this aberrant DNA methylation are unknown...
  7. Kang S, Lee J, Jeon E, Lee S, Kim H, Kim H, et al. RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma. Int J Cancer. 2006;119:1316-21 pubmed
    Both hypermethylation of the tumor suppressor gene RASSF1A and activating mutations of the KRAS and/or BRAF gene have been reported in a variety of human cancers...
  8. Guo W, Dong Z, Chen Z, Yang Z, Wen D, Kuang G, et al. Aberrant CpG island hypermethylation of RASSF1A in gastric cardia adenocarcinoma. Cancer Invest. 2009;27:459-65 pubmed publisher
    Ras-association domain family 1A (RASSF1A) gene, a candidate tumor suppressor gene, is inactivated in several human tumors, usually by hypermethylation of its promoter region...
  9. Liu L, Guo C, Dammann R, Tommasi S, Pfeifer G. RASSF1A interacts with and activates the mitotic kinase Aurora-A. Oncogene. 2008;27:6175-86 pubmed publisher
    The RAS association domain family 1A (RASSF1A) gene is located at chromosome 3p21.3 within a specific area of common heterozygous and homozygous deletions...
  10. Thaler S, Hähnel P, Schad A, Dammann R, Schuler M. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Cancer Res. 2009;69:1748-57 pubmed publisher
    Promoter hypermethylation preventing expression of the RAS association domain family 1 isoform A (RASSF1A) gene product is among the most abundant epigenetic deregulations in human cancer...
  11. Gao B, Xie X, Huang C, Shames D, Chen T, Lewis C, et al. RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. Cancer Res. 2008;68:22-5 pubmed publisher
    The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers...
  12. Liu L, Tommasi S, Lee D, Dammann R, Pfeifer G. Control of microtubule stability by the RASSF1A tumor suppressor. Oncogene. 2003;22:8125-36 pubmed
    The RAS association domain family 1A (RASSF1A) gene is silenced by DNA methylation in over 50% of all solid tumors of different histological types. However, the biochemical function of the RASSF1A protein is unknown...
  13. Praskova M, Khoklatchev A, Ortiz Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J. 2004;381:453-62 pubmed
    ..from KB cells is specifically associated with substoichiometric amounts of the growth inhibitory polypeptides RASSF1A and NORE1A (novel Ras effector 1A; a Ras-GTP-binding protein)...
  14. Choi N, Son D, Song I, Lee H, Lim Y, Song M, et al. RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer. Int J Cancer. 2005;115:575-81 pubmed
    Aberrant methylation of several tumor suppressor genes often occurs during the pathogenesis of lung cancer. RASSF1A is one of the tumor suppressor genes, and it is frequently inactivated by hypermethylation of its promoter region in a ..
  15. Sharma G, Mirza S, Yang Y, Parshad R, Hazrah P, Datta Gupta S, et al. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol. 2009;31:487-500 pubmed publisher
    ..Promoter hypermethylation was observed in PRB 67%, ERalpha 64%, RASSF1A 63%, p16INK4A 51%, RARbeta2 22%, GSTP1 25% and BRCA1 27% of the breast cancers, respectively...
  16. Buhmeida A, Merdad A, Al Maghrabi J, El Maghrabi J, Al Thobaiti F, Ata M, et al. RASSF1A methylation is predictive of poor prognosis in female breast cancer in a background of overall low methylation frequency. Anticancer Res. 2011;31:2975-81 pubmed
    ..events in a series of key genes including Ras association (RalGDS/AF-6) domain family member 1 isoform a (RASSF1A), hypermethylated in cancer 1 (HIC1), cyclin-dependent kinase inhibitor 2A (CDKN2A), retinoic acid receptor beta (..
  17. Dreijerink K, Braga E, Kuzmin I, Geil L, Duh F, Angeloni D, et al. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc Natl Acad Sci U S A. 2001;98:7504-9 pubmed
    ..Recently, the RAS association family 1 gene (isoform RASSF1A), located at 3p21.3, has been identified as a candidate lung and breast TSG...
  18. Müller H, Fiegl H, Widschwendter A, Widschwendter M. Prognostic DNA methylation marker in serum of cancer patients. Ann N Y Acad Sci. 2004;1022:44-9 pubmed
    ..In the gene evaluation set, we detected five genes (ESR1, APC, HSD17B4, HIC1, and RASSF1A) using our criteria for further analysis...
  19. Martins A, Monteiro P, Ramalho Carvalho J, Costa V, Dinis Ribeiro M, Leal C, et al. High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions. Breast Cancer Res Treat. 2011;129:1-9 pubmed publisher
    ..the evaluation of the prognostic value of quantitative promoter methylation at three gene loci (APC, CCND2, and RASSF1A) in a large series of FNA washings from breast lesions...
  20. Rong R, Jin W, Zhang J, Sheikh M, Huang Y. Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest. Oncogene. 2004;23:8216-30 pubmed
    b>RASSF1A is a putative tumor suppressor gene that is inactivated in a variety of human tumors. Expression of exogenous RASSF1A has been shown to inhibit tumor growth in vitro and in animals...
  21. Chen H, Suzuki M, Nakamura Y, Ohira M, Ando S, Iida T, et al. Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. Oncol Rep. 2006;15:1281-5 pubmed
    ..b>RASSF1A, regarded as a TSG, has been extensively studied in lung cancer and other malignant tumors, whereas RASGRF2 has ..
  22. Wang X, Di K, Zhang X, Han H, Wong Y, Leung S, et al. Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. Oncogene. 2008;27:4456-66 pubmed publisher
    ..During early mitosis, Id-1 interacts with Cdc20 and RASSF1A (Ras association domain family 1A), leading to enhanced APC(Cdc20) activity, which in turn promotes cyclin B1/..
  23. Burbee D, Forgacs E, Zochbauer Muller S, Shivakumar L, Fong K, Gao B, et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst. 2001;93:691-9 pubmed
    ..We assessed expression of two RASSF1 gene products, RASSF1A and RASSF1C, and the methylation status of their respective promoters in 27 non-small-cell lung cancer (NSCLC) ..
  24. Lo P, Xie D, Chan K, Xu F, Kuzmin I, Lerman M, et al. Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage. Cancer Lett. 2007;257:199-205 pubmed
    ..In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC)...
  25. Dammann R, Schagdarsurengin U, Strunnikova M, Rastetter M, Seidel C, Liu L, et al. Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol Histopathol. 2003;18:665-77 pubmed publisher
    ..At least two forms of RASSF1 are present in normal human cells. The RASSF1A isoform is highly epigenetically inactivated in lung, breast, ovarian, kidney, prostate, thyroid and several ..
  26. Foley C, Freedman H, Choo S, Onyskiw C, Fu N, Yu V, et al. Dynamics of RASSF1A/MOAP-1 association with death receptors. Mol Cell Biol. 2008;28:4520-35 pubmed publisher
    b>RASSF1A is a tumor suppressor protein involved in death receptor-dependent apoptosis utilizing the Bax-interacting protein MOAP-1 (previously referred to as MAP-1)...
  27. Karray Chouayekh S, Trifa F, Khabir A, Boujelbane N, Sellami Boudawara T, Daoud J, et al. Aberrant methylation of RASSF1A is associated with poor survival in Tunisian breast cancer patients. J Cancer Res Clin Oncol. 2010;136:203-10 pubmed publisher
    ..study was to determine the methylation status of the promoter region CpG islands of four cancer-related genes RASSF1A, RARbeta2, CDH1, and p16 ( INK4a ) in 78 breast cancer specimens and to evaluate whether the methylation status ..
  28. Buckingham L, Penfield Faber L, Kim A, Liptay M, Barger C, Basu S, et al. PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients. Int J Cancer. 2010;126:1630-9 pubmed publisher
    ..These results show that methylation of specific promoter CpG sites in PTEN, RASSF1 and DAPK is associated with outcome in early stage surgically treated NSCLC. ..
  29. Song S, Kim S, Song M, Lim D. Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res. 2009;69:8540-4 pubmed publisher
    ..The tumor suppressor RASSF1A regulates cell cycle progression by regulating mitotic progression, G(1)-S transition, and microtubule stability...
  30. Kim D, Kim J, Ji Y, Shim Y, Kim H, Han J, et al. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res. 2003;63:3743-6 pubmed
    ..We studied the association between the age at starting smoking and hypermethylation of p14, p16, and RASSF1A promoters in 204 primary non-small cell lung cancer patients...
  31. Tokinaga K, Okuda H, Nomura A, Ashida S, Furihata M, Shuin T. Hypermethylation of the RASSF1A tumor suppressor gene in Japanese clear cell renal cell carcinoma. Oncol Rep. 2004;12:805-10 pubmed
    Hypermethylation associated inactivation of RASSF1A tumor suppressor gene at chromosome 3p21.3 has been observed in several human malignancies...
  32. Dammann R, Schagdarsurengin U, Seidel C, Strunnikova M, Rastetter M, Baier K, et al. The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol Histopathol. 2005;20:645-63 pubmed publisher
    ..others have identified a novel Ras effector at this segment, which was termed Ras Association Domain family 1 (RASSF1A) gene...
  33. Schagdarsurengin U, Seidel C, Ulbrich E, Kolbl H, Dittmer J, Dammann R. A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast. Int J Oncol. 2005;27:185-91 pubmed
    The tumor suppressor gene RASSF1A is inactivated or mutated in different tumor entities including breast cancer. The frequency of the genomic variants of RASSF1A in patients with breast tumors has not been evaluated...
  34. Fernandes M, Carneiro F, Oliveira C, Seruca R. Colorectal cancer and RASSF family--a special emphasis on RASSF1A. Int J Cancer. 2013;132:251-8 pubmed publisher
    ..In particular, RASSF1A, RASSF2 and RASSF5 methylation has been associated with CRC development, though the mechanisms of action remain ..
  35. Baksh S, Tommasi S, Fenton S, Yu V, Martins L, Pfeifer G, et al. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Mol Cell. 2005;18:637-50 pubmed
    ..We report that the tumor suppressor gene RASSF1A is required for death receptor-induced Bax conformational change and apoptosis...
  36. Roupret M, Hupertan V, Catto J, Yates D, Rehman I, Proctor L, et al. Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. Int J Cancer. 2008;122:952-6 pubmed
    ..The extent of this hypermethylation increases during disease progression and can be used to identify the extent and duration of treatment response in prostate cancer. ..
  37. Ahlquist T, Bottillo I, Danielsen S, Meling G, Rognum T, Lind G, et al. RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A. Neoplasia. 2008;10:680-6, 2 p following 686 pubmed
    ..The mutational hot spots in KRAS and BRAF were sequenced, and promoter hypermethylation status of RASSF1A was assessed with a methylation-specific polymerase chain reaction...
  38. Reeves M, Baldwin S, Baldwin M, Chen S, Moretz J, Aragon R, et al. Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis. BMC Cancer. 2010;10:562 pubmed publisher
    The Ras association domain family 1 (RASSF1) gene is a Ras effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative promoter selection and alternative mRNA splicing. RASSF1A is a tumor suppressor gene...
  39. Palakurthy R, Wajapeyee N, Santra M, Gazin C, Lin L, Gobeil S, et al. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell. 2009;36:219-30 pubmed publisher
    The RASSF1A tumor suppressor gene is epigenetically silenced in a variety of cancers. Here, we perform a genome-wide human shRNA screen and find that epigenetic silencing of RASSF1A requires the homeobox protein HOXB3...
  40. El Kalla M, Onyskiw C, Baksh S. Functional importance of RASSF1A microtubule localization and polymorphisms. Oncogene. 2010;29:5729-40 pubmed publisher
    Ras association domain family protein 1A (RASSF1A) is one of the more heavily methylated genes in human cancers. In addition to promoter-specific methylation, RASSF1A polymorphisms have been identified in cancer patients...
  41. Wong I, Chan J, Wong J, Tam P. Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia. Clin Cancer Res. 2004;10:994-1002 pubmed
    The role of RASSF1A has been elucidated recently in regulating apoptosis and cell cycle progression by inhibiting cyclin D1 accumulation. Aberrant RASSF1A promoter methylation has been found frequently in multiple adult cancer types...
  42. Kawamoto K, Okino S, Place R, Urakami S, Hirata H, Kikuno N, et al. Epigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer. Clin Cancer Res. 2007;13:2541-8 pubmed
    The RAS-association domain family 1, isoform A (RASSF1A) gene is shown to be inactivated in prostate cancers. However, the molecular mechanism of silencing of the RASSFIA gene is not fully understood...
  43. Misawa A, Tanaka S, Yagyu S, Tsuchiya K, Iehara T, Sugimoto T, et al. RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker. Br J Cancer. 2009;100:399-404 pubmed publisher
    The tumour suppressor gene RASSF1A is known to be frequently silenced by promoter hypermethylation in neuroblastoma tumours...
  44. Vos M, Dallol A, Eckfeld K, Allen N, Donninger H, Hesson L, et al. The RASSF1A tumor suppressor activates Bax via MOAP-1. J Biol Chem. 2006;281:4557-63 pubmed
    The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation...
  45. Guo C, Tommasi S, Liu L, Yee J, Dammann R, Pfeifer G. RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol. 2007;17:700-5 pubmed
    The Ras Association Domain Family 1A (RASSF1A) gene is one of the most frequently silenced genes in human cancer. RASSF1A has been shown to interact with the proapoptotic kinase MST1...
  46. Dammann R, Li C, Yoon J, Chin P, Bates S, Pfeifer G. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet. 2000;25:315-9 pubmed
    ..Loss of expression was correlated with methylation of the CpG-island promoter sequence of RASSF1A. The promoter was highly methylated in 24 of 60 (40%) primary lung tumours, and 4 of 41 tumours analysed carried ..
  47. Rabizadeh S, Xavier R, Ishiguro K, Bernabeortiz J, Lopez Ilasaca M, Khokhlatchev A, et al. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem. 2004;279:29247-54 pubmed
    ..CNK1 does, however, bind directly to the RASSF1A and RASSF1C polypeptides, constitutive binding partners of the MST1/2 kinases...
  48. Kuzmin I, Gillespie J, Protopopov A, Geil L, Dreijerink K, Yang Y, et al. The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. Cancer Res. 2002;62:3498-502 pubmed
    ..We found complete methylation of the RASSF1A promoter in 63% of primary microdissected prostate carcinomas (7 of 11 samples)...
  49. Hogg R, Honorio S, Martinez A, Agathanggelou A, Dallol A, Fullwood P, et al. Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma. Eur J Cancer. 2002;38:1585-92 pubmed
    ..only rare mutations, but the majority of lung tumour lines showed loss of expression for one of the eight genes (RASSF1A) due to hypermethylation of a CpG island in the promoter region of RASSF1A...
  50. Endoh H, Yatabe Y, Shimizu S, Tajima K, Kuwano H, Takahashi T, et al. RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. Int J Cancer. 2003;106:45-51 pubmed
    ..RT-PCR analysis showed no expression of RASSF1A in 12 of 20 lung cancer cell lines...
  51. Liu L, Baier K, Dammann R, Pfeifer G. The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex. Cell Cycle. 2007;6:1663-5 pubmed
    It has been reported that the RASSF1A tumor suppressor protein controls mitotic progression by binding to and inhibiting Cdc20, an activator of the anaphase-promoting complex...
  52. Calipel A, Abonnet V, Nicole O, Mascarelli F, Coupland S, Damato B, et al. Status of RASSF1A in uveal melanocytes and melanoma cells. Mol Cancer Res. 2011;9:1187-98 pubmed publisher
    b>RASSF1A gene, found at the 3p21.3 locus, is a tumor suppressor gene frequently hypermethylated in human cancers...
  53. Sebova K, Zmetakova I, Bella V, Kajo K, Stankovicova I, Kajabova V, et al. RASSF1A and CDH1 hypermethylation as potential epimarkers in breast cancer. Cancer Biomark. 2011;10:13-26 pubmed publisher
    ..the relation between DNA methylation level and breast cancer progression, we analysed DNA methylation in RASSF1A and CDH1 promoters using quantitative multiplex methylation-specific PCR in paraffin-embedded tumour tissues and ..
  54. Kim J, Chae Y, Ha Y, Kim I, Byun S, Yun S, et al. Ras association domain family 1A: a promising prognostic marker in recurrent nonmuscle invasive bladder cancer. Clin Genitourin Cancer. 2012;10:114-20 pubmed publisher
    The aim of this study was to investigate the value of RASSF1A methylation as a prognostic marker in bladder cancer. RASSF1A hypermethylation from 301 specimens of primary BC tissue was assessed using methylation-specific PCR...
  55. Song M, Song S, Ayad N, Chang J, Lee J, Hong H, et al. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol. 2004;6:129-37 pubmed
    The tumour suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic tumours as a result of hypermethylation of a CpG island in its promoter...
  56. Pan Z, Kashuba V, Liu X, Shao J, Zhang R, Jiang J, et al. High frequency somatic mutations in RASSF1A in nasopharyngeal carcinoma. Cancer Biol Ther. 2005;4:1116-22 pubmed
    ..3 region is a common event in various kinds of tumors including nasopharyngeal carcinoma (NPC). RASSF1A has been identified as a putative tumor suppressor gene residing in this region...
  57. Pelosi G, Fumagalli C, Trubia M, Sonzogni A, Rekhtman N, Maisonneuve P, et al. Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung. Anticancer Res. 2010;30:4269-81 pubmed
    ..043) expression in ATC, suggesting that 3p21.3 allelic loss contributed to the loss of gene expression. RASSF1 A/E is likely to act as a tumor suppressor gene in most pulmonary NET, and RASSF1 C as an oncogene in high-grade tumors. ..
  58. Giovinazzi S, Lindsay C, Morozov V, Escobar Cabrera E, Summers M, Han H, et al. Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene. 2012;31:13-26 pubmed publisher
    ..Daxx and Rassf1 may become useful predictive markers for the proper selection of patients for taxane chemotherapy. ..
  59. Honorio S, Agathanggelou A, Schuermann M, Pankow W, Viacava P, Maher E, et al. Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients. Oncogene. 2003;22:147-50 pubmed
    The newly identified 3p21.3 tumour suppressor gene RASSF1A is methylated in the majority of primary lung tumours, lung tumour cell lines and in a variable percentage of breast tumours...
  60. Yeo W, Wong W, Wong N, Law B, Tse G, Zhong S. High frequency of promoter hypermethylation of RASSF1A in tumorous and non-tumourous tissue of breast cancer. Pathology. 2005;37:125-30 pubmed
    To determine the presence of RASSF1A promoter methylation in tumorous and non-tumorous tissues of breast cancer...
  61. Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D, et al. RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell. 2007;27:962-75 pubmed
    b>RASSF1A is a tumor suppressor gene that is epigenetically silenced in a wide variety of sporadic human malignancies. Expression of alternative RASSF1 isoforms cannot substitute for RASSF1A-promoted cell-cycle arrest and apoptosis...
  62. Malpeli G, Amato E, Dandrea M, Fumagalli C, Debattisti V, Boninsegna L, et al. Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors. BMC Cancer. 2011;11:351 pubmed publisher
    b>RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied...
  63. Reeves M, Baldwin M, Aragon R, Baldwin S, Chen S, Li X, et al. RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1. BMC Res Notes. 2012;5:239 pubmed publisher
    b>RASSF1A and RASSF1C are two major isoforms encoded by the Ras association domain family 1 (RASSF1) gene through alternative promoter selection and mRNA splicing. RASSF1A is a well established tumor suppressor gene...
  64. Shivakumar L, Minna J, Sakamaki T, Pestell R, White M. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol. 2002;22:4309-18 pubmed
    The RASSF1A locus at 3p21.3 is epigenetically inactivated at high frequency in a variety of solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human cancer cell lines...
  65. Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Mori M, et al. Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res. 2003;63:3724-8 pubmed
    ..of von Hippel-Lindau disease (VHL), retinoic acid receptor beta (RAR-beta), RAS association domain family 1A (RASSF1A), and fragile histidine triad (FHIT) genes in 22 esophageal squamous cell carcinoma cell lines and 47 primary ..
  66. Murray P, Qiu G, Fu L, Waites E, Srivastava G, Heys D, et al. Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphoma. Oncogene. 2004;23:1326-31 pubmed
    Epigenetic inactivation of RASSF1A, a putative tumor suppressor with proapoptotic activity, is frequently observed in a number of solid tumors, including a variety of epithelial cancers, but has not been described in hematopoietic tumors...
  67. Kioulafa M, Kaklamanis L, Mavroudis D, Georgoulias V, Lianidou E. Prognostic significance of RASSF1A promoter methylation in operable breast cancer. Clin Biochem. 2009;42:970-5 pubmed publisher
    The aim of our study was to evaluate the prognostic significance of RASSF1A promoter methylation status in operable breast cancer...
  68. Ortiz Vega S, Khokhlatchev A, Nedwidek M, Zhang X, Dammann R, Pfeifer G, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002;21:1381-90 pubmed
    Nore and RASSF1A are noncatalytic proteins that share 50% identity over their carboxyterminal 300 AA, a segment that encompasses a putative Ras-Rap association (RA) domain...
  69. Yu M, Tong J, Chan P, Lee T, Chan M, Chan A, et al. Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers. Int J Cancer. 2003;105:204-9 pubmed
    ..The candidate tumor suppressor gene, RASSF1A located at 3p21...
  70. Marsit C, Kim D, Liu M, Hinds P, Wiencke J, Nelson H, et al. Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. Int J Cancer. 2005;114:219-23 pubmed
    The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer...
  71. Kanzaki H, Hanafusa H, Yamamoto H, Yasuda Y, Imai K, Yano M, et al. Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. Cancer Lett. 2006;238:128-34 pubmed
    ..The increased risk of the heterozygous genotype is intriguing, implying a close relation with the dimerization feature of RASSF1 proteins. ..
  72. Choi Y, Kang S, Shin Y, Choi J, Kim S, Lee S, et al. Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas. Virchows Arch. 2006;448:331-6 pubmed
    The newly identified 3p21.3 tumor suppressor gene RASSF1A is inactivated by hypermethylation in variable solid tumors, including those of the lung, breast, prostate, kidney, and ovary...
  73. Di Gioia S, Bianchi P, Destro A, Grizzi F, Malesci A, Laghi L, et al. Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. BMC Cancer. 2006;6:89 pubmed
    Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling...
  74. Kawai Y, Sakano S, Suehiro Y, Okada T, Korenaga Y, Hara T, et al. Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma. Ann Oncol. 2010;21:1612-7 pubmed publisher
    Ras association domain family 1A (RASSF1A) is a tumor suppressor that regulates the cell cycle, apoptosis, and microtubule stability...
  75. Bondurant A, Huang Z, Whitaker R, Simel L, Berchuck A, Murphy S. Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. Gynecol Oncol. 2011;123:581-7 pubmed publisher
    ..Our objectives were to develop an absolute quantitative method for detection of DNA methylation using RASSF1A, a known target of promoter methylation in ovarian cancer, and test the ability to detect RASSF1A methylation in ..
  76. Dammann R, Yang G, Pfeifer G. Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res. 2001;61:3105-9 pubmed
    The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21...
  77. Harada K, Toyooka S, Maitra A, Maruyama R, Toyooka K, Timmons C, et al. Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines. Oncogene. 2002;21:4345-9 pubmed
    ..Therefore, we examined the methylation status of nine genes (p16(INK4A), MGMT, GSTP1, RASSF1A, APC, DAPK, RARbeta, CDH1 and CDH13) in 175 primary pediatric tumors and 23 tumor cell lines using methylation-..
  78. Agathanggelou A, Cooper W, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 2005;65:3497-508 pubmed
    ..3 resulted in the identification of the RAS-association domain family 1, isoform A gene (RASSF1A). RASSF1A falls into the category of genes frequently inactivated by methylation rather than mutational events...
  79. Xue W, Li C, Zhou X, Guan H, Qin L, Li P, et al. RASSF1A expression inhibits the growth of hepatocellular carcinoma from Qidong County. J Gastroenterol Hepatol. 2008;23:1448-58 pubmed
    The tumor-suppressing role of Ras-association domain family 1A (RASSF1A) has been described in several systems...
  80. Kee S, Lee J, Kim M, Lee S, Jung Y, Kim Y, et al. Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer. Mol Cells. 2007;24:364-71 pubmed
    The tumor suppressor gene Ras association domain family 1A (RASSF1A) is highly methylated in a wide range of human sporadic tumors...
  81. Jiang Y, Cui L, Chen W, Shen S, Ding L. The prognostic role of RASSF1A promoter methylation in breast cancer: a meta-analysis of published data. PLoS ONE. 2012;7:e36780 pubmed publisher
    ..We present the results of a meta-analysis of the associations between RASSF1A promoter methylation status and both disease free survival (DFS) and overall survival (OS) in female breast ..
  82. Fackler M, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak K, et al. DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer. 2003;107:970-5 pubmed
    ..The promoter methylation status of 5 cancer-related genes (RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist) was evaluated in 2 types of lobular cancers, in situ (LCIS) and invasive ..
  83. Dallol A, Agathanggelou A, Tommasi S, Pfeifer G, Maher E, Latif F. Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res. 2005;65:7653-9 pubmed
    We have previously shown that RASSF1A associates with the microtubules. This association alters the microtubule dynamics and seems essential for RASSF1A tumor suppressive function...
  84. Wong N, Li L, Tsang K, Lai P, To K, Johnson P. Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma. J Hepatol. 2002;37:633-9 pubmed
    ..with a minimal deleted region of 3p13-p21 has prompted our further investigation on the tumor suppressor gene RASSF1A, located at 3p21.3...
  85. Dong S, Sun D, Benoit N, Kuzmin I, Lerman M, Sidransky D. Epigenetic inactivation of RASSF1A in head and neck cancer. Clin Cancer Res. 2003;9:3635-40 pubmed
    b>RASSF1A, a recently identified candidate tumor suppressor gene, was found to be inactivated in lung cancer and other tumor types. We sought to understand the role of RASSF1A in head and neck cancer...
  86. Amaar Y, Baylink D, Mohan S. Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. J Bone Miner Res. 2005;20:1430-9 pubmed
  87. Pijnenborg J, Dam de Veen G, Kisters N, Delvoux B, van Engeland M, Herman J, et al. RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer. Ann Oncol. 2007;18:491-7 pubmed
    ..carcinoma were compared regarding the presence of K-ras mutations (codons 12 and 13), B-raf mutations (V599), and RASSF1A gene promoter methylation. K-ras mutations were present in 18% of the patients independent of recurrent disease...
  88. Jagadeesh S, Sinha S, Pal B, Bhattacharya S, Banerjee P. Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells. Biochem Biophys Res Commun. 2007;362:212-7 pubmed
    ..Several recent reports suggest that suppression of RASSF1A is associated with the advanced grade and stage of prostate cancer and many other cancers...
  89. Inda M, Castresana J. RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system. Neuropathology. 2007;27:341-6 pubmed
    ..Some studies have suggested that MB and sPNET present different molecular genetic aberrations. The RASSF1A (Ras Association Domain Family Protein 1) gene, located at 3p21...
  90. Song M, Song S, Kim S, Nakayama K, Nakayama K, Lim D. Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition. Oncogene. 2008;27:3176-85 pubmed
    The tumor suppressor RASSF1A is inactivated in many human cancers and is implicated in regulation of microtubule stability, cell cycle progression and apoptosis...
  91. Escobar Cabrera E, Lau D, Giovinazzi S, Ishov A, McIntosh L. Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C. Structure. 2010;18:1642-53 pubmed publisher
    ..These data provide a structural foundation for understanding the diverse functions of DAXX. ..
  92. Vos M, Ellis C, Bell A, Birrer M, Clark G. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J Biol Chem. 2000;275:35669-72 pubmed
    ..Thus, the RASSF1 tumor suppressor may serve as a novel Ras effector that mediates the apoptotic effects of oncogenic Ras. ..