Gene Symbol: RASA1
Description: RAS p21 protein activator 1
Alias: CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP, ras GTPase-activating protein 1, RAS p21 protein activator (GTPase activating protein) 1, p120 RAS GTPase activating protein, triphosphatase-activating protein
Species: human
Products:     RASA1

Top Publications

  1. Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, et al. A Ras-GTPase-activating protein SH3-domain-binding protein. Mol Cell Biol. 1996;16:2561-9 pubmed
    We report the purification of a Ras-GTPase-activating protein (GAP)-binding protein, G3BP, a ubiquitously expressed cytosolic 68-kDa protein that coimmunoprecipitates with GAP...
  2. Hecker T, Ding Q, Rege T, Hanks S, Gladson C. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene. 2004;23:3962-71 pubmed
    ..The overexpression of FAK also promoted the association of FAK with p120RasGAP, which is a negative regulator of Ras activity, in the U-251MG cells cultured in aggregate suspension, with this ..
  3. Kazlauskas A, Ellis C, Pawson T, Cooper J. Binding of GAP to activated PDGF receptors. Science. 1990;247:1578-81 pubmed
    ..products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused ..
  4. Gallouzi I, Parker F, Chebli K, Maurier F, Labourier E, Barlat I, et al. A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. Mol Cell Biol. 1998;18:3956-65 pubmed
    A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP...
  5. Yang J, Widmann C. The RasGAP N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation. J Biol Chem. 2002;277:14641-6 pubmed
    b>RasGAP, a regulator of Ras GTPase family members, is cleaved at low levels of caspase activity into an N-terminal fragment (fragment N) that generates potent anti-apoptotic signals...
  6. Koch C, Moran M, Anderson D, Liu X, Mbamalu G, Pawson T. Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992;12:1366-74 pubmed
    ..and transforming proteins, including cytoplasmic protein-tyrosine kinases and Ras GTPase-activating protein (GAP)...
  7. Tocque B, Delumeau I, Parker F, Maurier F, Multon M, Schweighoffer F. Ras-GTPase activating protein (GAP): a putative effector for Ras. Cell Signal. 1997;9:153-8 pubmed
    One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological ..
  8. Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149:457-70 pubmed
    We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration...
  9. Yang J, Michod D, Walicki J, Murphy B, Kasibhatla S, Martin S, et al. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol. 2004;24:10425-36 pubmed
    ..This mechanism relies on the partial cleavage of RasGAP by caspase 3 into an amino-terminal fragment called fragment N...

More Information

Publications104 found, 100 shown here

  1. Boon L, Mulliken J, Vikkula M. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005;15:265-9 pubmed
    ..Candidate gene screening pinpointed mutations in RASA1 (p120-RASGAP) - a RasGTPase. RASA1 reverts active GTP-bound Ras into inactive GDP-bound form...
  2. Tomar A, Lim S, Lim Y, Schlaepfer D. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009;122:1852-62 pubmed publisher
    ..and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation...
  3. de Wijn R, Oduber C, Breugem C, Alders M, Hennekam R, van der Horst C. Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. Eur J Med Genet. 2012;55:191-5 pubmed publisher
    Hereditary capillary malformations are known to be caused by mutations in the RASA1 gene. The associated phenotype is still subject of debate...
  4. Druker B, Okuda K, Matulonis U, Salgia R, Roberts T, Griffin J. Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. Blood. 1992;79:2215-20 pubmed
    ..We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines...
  5. Trahey M, Wong G, Halenbeck R, Rubinfeld B, Martin G, Ladner M, et al. Molecular cloning of two types of GAP complementary DNA from human placenta. Science. 1988;242:1697-700 pubmed
    The ras p21 GTPase-activating protein (GAP) was purified from human placental tissue...
  6. Scheffzek K, Ahmadian M, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F, et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 1997;277:333-8 pubmed
    ..diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms...
  7. Eerola I, Boon L, Mulliken J, Burrows P, Dompmartin A, Watanabe S, et al. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet. 2003;73:1240-9 pubmed
    ..A positional candidate gene, RASA1, encoding p120-RasGAP, was screened for mutations in 17 families...
  8. Yang J, Walicki J, Abderrahmani A, Cornu M, Waeber G, Thorens B, et al. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. J Biol Chem. 2005;280:32835-42 pubmed
    ..b>RasGAP, a regulator of Ras and Rho GTPases, is an atypical caspase substrate, since it inhibits, rather than favors, ..
  9. Revencu N, Boon L, Mulliken J, Enjolras O, Cordisco M, Burrows P, et al. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat. 2008;29:959-65 pubmed publisher
    ..malformation (CM-AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations and the associated phenotype in 44 families...
  10. Ellis C, Moran M, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990;343:377-81 pubmed
    ..The presence of two adjacent SH2 domains in the p21ras GTPase-activating protein (GAP) indicates that GAP might interact directly with tyrosine kinases...
  11. Mitsudomi T, Friedman E, Gejman P, McCormick F, Gazdar A. Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines. Hum Genet. 1994;93:27-31 pubmed
    ..in its GTP-bound form and insensitive to the hydrolytic action of the ras-specific GTPase-activating protein (ras GAP)...
  12. Hershkovitz D, Bergman R, Sprecher E. A novel mutation in RASA1 causes capillary malformation and limb enlargement. Arch Dermatol Res. 2008;300:385-8 pubmed publisher
    ..Mutations in the RASA1 gene have been shown to underlie the capillary malformation-arterio-venous malformation (CM-AVM) syndrome, ..
  13. Settleman J, Narasimhan V, Foster L, Weinberg R. Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. Cell. 1992;69:539-49 pubmed
    ..stimulated and tyrosine kinase-transformed cells, a substantial fraction of the ras GTPase-activating protein (GAP) forms a complex with a protein termed p190. We have cloned several cDNAs encoding the p190 protein...
  14. Hu K, Settleman J. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J. 1997;16:473-83 pubmed
    ..p120 RasGAP (GTPase-activating protein), which contains an SH3 domain flanked by two SH2 domains, forms an abundant SH2-..
  15. Bradley W, Hernandez S, Settleman J, Koleske A. Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell. 2006;17:4827-36 pubmed
    ..p190 phosphorylation promotes its binding to p120RasGAP (p120). Here, we elucidate the mechanism by which p120 binding regulates p190 activation after adhesion...
  16. Pamonsinlapatham P, Gril B, Dufour S, Hadj Slimane R, Gigoux V, Pethe S, et al. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell Signal. 2008;20:2119-26 pubmed publisher
    Ras GTPase-activating protein (RasGAP) is hypothesized to be an effector of oncogenic Ras stimulating numerous downstream cellular signaling cascades involved in survival, proliferation and motility...
  17. Anand S, Majeti B, Acevedo L, Murphy E, Mukthavaram R, Scheppke L, et al. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med. 2010;16:909-14 pubmed publisher
    ..Here we show that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducing neovascularization...
  18. Annibaldi A, Dousse A, Martin S, Tazi J, Widmann C. Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1. PLoS ONE. 2011;6:e29024 pubmed publisher
    b>RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3...
  19. Moutal A, Dustrude E, Khanna R. Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1. Mol Neurobiol. 2017;54:3342-3349 pubmed publisher
    ..Nf1 encodes for neurofibromin, a Ras GTPase-activating protein (Ras GAP) that has been implicated in the regulation of long-term potentiation (LTP), Ras/ERK (extracellular signal-..
  20. Ramachandran B, Stabley J, Cheng S, Behrmann A, Gay A, Li L, et al. A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells. J Biol Chem. 2018;293:7942-7968 pubmed publisher
    ..Co-transfection studies confirm that G3BP1 (G3BP is Ras-GAP SH3 domain-binding protein) methylation is inhibited by LRP6 and that G3BP1 stimulates NFATc4 transcription...
  21. Cao Y, Banks D, Mattei A, Riddick A, Reed K, Zhang A, et al. Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic Localization, Decreases Its Phosphorylation, and Increases Detyrosination of Tubulin. Int J Mol Sci. 2019;20: pubmed publisher
    ..kinase) phosphoserine/threonine/tyrosine-binding protein) interacts with the stress granule nucleator G3BP-1 (Ras-GAP (GTPase-activating protein) SH3 (Src homology 3) domain-binding protein-1), and decreases stress granule (stalled ..
  22. Laukkanen M, Cammarota F, Esposito T, Salvatore M, Castellone M. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS ONE. 2015;10:e0121441 pubmed publisher
    ..of guanine nucleotide-exchange factors (RHO GEF16, RAL GEF RGL1), GTPase-activating proteins (ARFGAP ADAP2, RAS GAP RASAL1, RGS4), and a Rho guanine nucleotide-disassociation inhibitor (RHO GDI 2) in a dose dependent manner, thus ..
  23. Pan Y, Tong J, Lung R, Kang W, Kwan J, Chak W, et al. RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer. Mol Cancer. 2018;17:102 pubmed publisher
    ..RASAL2 encodes a RAS-GTPase-activating protein (RAS-GAP) and showed increased expression in CRC cell lines and clinical specimens...
  24. Kossler N, Stricker S, Rödelsperger C, Robinson P, Kim J, Dietrich C, et al. Neurofibromin (Nf1) is required for skeletal muscle development. Hum Mol Genet. 2011;20:2697-709 pubmed publisher
    Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signaling...
  25. Deraredj Nadim W, Chaumont Dubel S, Madouri F, Cobret L, de Tauzia M, Zajdel P, et al. Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. Proc Natl Acad Sci U S A. 2016;113:12310-12315 pubmed
    ..Constitutive activity is strongly reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a 5-HT6 receptor partner...
  26. Zhang Y, Deng X, Jiang D, Luo X, Tang K, Zhao Z, et al. Long-term results of anterior cervical corpectomy and fusion with nano-hydroxyapatite/polyamide 66 strut for cervical spondylotic myelopathy. Sci Rep. 2016;6:26751 pubmed publisher
    ..The "radiolucent gap" at the interface between the n-HA/PA66 strut and the vertebra was further noted to evaluate the osteoconductivity ..
  27. Crooke P, Olswang L. Practice-Based Research: Another Pathway for Closing the Research-Practice Gap. J Speech Lang Hear Res. 2015;58:S1871-82 pubmed publisher
  28. Kljucevsek D, Kompan L. Reliability of measurement techniques for the hepato-splanchnic region in multiple-trauma patients. Eur J Trauma Emerg Surg. 2011;37:577-81 pubmed publisher
    ..study was to investigate the relationship between the difference in intra-mucosal and arterial CO2 pressure (pCO2 gap) and the outcome in multiply injured patients and relations between the pCO2 gap and intestinal permeability (IP)...
  29. Mwenda G, O Hara G, De Meyer S, Howieson J, Terpolilli J. Genetic diversity and symbiotic effectiveness of Phaseolus vulgaris-nodulating rhizobia in Kenya. Syst Appl Microbiol. 2018;41:291-299 pubmed publisher
    ..To address this gap in knowledge, 178 isolates recovered from the root nodules of P...
  30. Ledri M, Sørensen A, Madsen M, Christiansen S, Ledri L, Cifra A, et al. Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus. J Neurosci. 2015;35:9622-31 pubmed publisher
    ..Translation of findings from animal models to humans represents an unresolved gap in most of the preclinical studies...
  31. Reid N, Dawe S, Shelton D, Harnett P, Warner J, Armstrong E, et al. Systematic Review of Fetal Alcohol Spectrum Disorder Interventions Across the Life Span. Alcohol Clin Exp Res. 2015;39:2283-95 pubmed publisher
    ..In addition, the lack of interventions for adolescents and adults further highlights the widening developmental gap and the potential influence of secondary disabilities for this at-risk population.
  32. Crowson M, Ramprasad V, Chapurin N, Cunningham C, Kaylie D. Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. Laryngoscope. 2016;126:2574-2579 pubmed publisher
    ..Audiologic outcomes included pre-/postoperative air bone gap (ABG) and word recognition score (WRS)...
  33. van Loo E, Krikke C, Hofker H, Berger S, Leuvenink H, Pol R. Outcome of pancreas transplantation from donation after circulatory death compared to donation after brain death. Pancreatology. 2017;17:13-18 pubmed publisher
    To overcome the gap of organ shortage grafts from donation after circulatory death (DCD) can be used. This review evaluates the outcomes after DCD pancreas donation compared to donation after brain death (DBD)...
  34. Aungkulanon S, Tangcharoensathien V, Shibuya K, Bundhamcharoen K, Chongsuvivatwong V. Area-level socioeconomic deprivation and mortality differentials in Thailand: results from principal component analysis and cluster analysis. Int J Equity Health. 2017;16:117 pubmed publisher
    ..These findings warrant future epidemiological studies investigating various causes of excessive deaths in non-deprived areas and implementation of policies to reduce the mortality gap between rich and poor areas.
  35. Van der Stigchel S, Hessels R, van Elst J, Kemner C. The disengagement of visual attention in the gap paradigm across adolescence. Exp Brain Res. 2017;235:3585-3592 pubmed publisher
    ..The efficiency of attentional disengagement is commonly assessed using the gap paradigm...
  36. Yoon J, Yang J. Satisfactory Short-Term Results of Navigation-Assisted Gap-Balancing Total Knee Arthroplasty Using Ultracongruent Insert. J Arthroplasty. 2017;: pubmed publisher
    ..The purpose of this study was to analyze the short-term clinical and radiologic results of UC insert TKA using the navigation-assisted gap-balancing technique.
  37. Al Ali H, Lee D, Danzi M, Nassif H, Gautam P, Wennerberg K, et al. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth. ACS Chem Biol. 2015;10:1939-51 pubmed publisher
    ..To address this gap, we combined the two drug discovery approaches using machine learning and information theory...
  38. Tingstad L, Olsen S, Klanderud K, Vandvik V, Ohlson M. Temperature, precipitation and biotic interactions as determinants of tree seedling recruitment across the tree line ecotone. Oecologia. 2015;179:599-608 pubmed publisher
    ..Seedling emergence, establishment and biomass were higher in gap plots compared to intact vegetation at all temperature levels...
  39. Formentini T, Legros S, Fernandes C, Pinheiro A, Le Bars M, Levard C, et al. Radical change of Zn speciation in pig slurry amended soil: Key role of nano-sized sulfide particles. Environ Pollut. 2017;222:495-503 pubmed publisher
    ..This study was designed to fill this gap. Using SEM-EDS and XAS analysis, we reported the following new results: (i) ZnS made up 100% of the Zn speciation ..
  40. Prunier J, Caron S, MacKay J. CNVs into the wild: screening the genomes of conifer trees (Picea spp.) reveals fewer gene copy number variations in hybrids and links to adaptation. BMC Genomics. 2017;18:97 pubmed publisher
    ..A genome-scale understanding of CNVs is available in a few plants but none are wild species, leaving a knowledge gap regarding their genome biology and evolutionary role...
  41. Boucher J, Monvoisin A, Vix J, Mesnil M, Thuringer D, Debiais F, et al. Connexins, important players in the dissemination of prostate cancer cells. Biochim Biophys Acta Biomembr. 2018;1860:202-215 pubmed publisher
    Over the past 50years, increasing experimental evidences have established that connexins (Cxs) and gap junctional intercellular communication (GJIC) ensure an important role in both the onset and development of cancerous processes...
  42. Chen X, Dong Y, Yu X. On the predictive validity of various corpus-based frequency norms in L2 English lexical processing. Behav Res Methods. 2018;50:1-25 pubmed publisher
    ..To bridge the gap, in the present study we took English as a case in point and compared the predictive power of a large set of corpus-..
  43. Noble S, Matzdorff A, Maraveyas A, Holm M, Pisa G. Assessing patients' anticoagulation preferences for the treatment of cancer-associated thrombosis using conjoint methodology. Haematologica. 2015;100:1486-92 pubmed publisher
    ..injections may lead to an increased prescribing of warfarin or non-vitamin K oral antagonists despite the evidence gap. There has been no evaluation of cancer patient preferences for anticoagulants and whether such an evidence gap is ..
  44. Zermiani M, Zonin E, Nonis A, Begheldo M, Ceccato L, Vezzaro A, et al. Ethylene negatively regulates transcript abundance of ROP-GAP rheostat-encoding genes and affects apoplastic reactive oxygen species homeostasis in epicarps of cold stored apple fruits. J Exp Bot. 2015;66:7255-70 pubmed publisher
    ..disorder, was used as a model to study relationships among ethylene action, the regulation of the ROP-GAP rheostat, and maintenance of H2O2 homeostasis in fruits during prolonged cold exposure...
  45. Ciccone A. [Role of rhythmicity in infant development]. Encephale. 2015;41:S15-21 pubmed publisher
    ..In infants, as in each one of us, rhythmicity organizes a foundation of permanence and bridges the gap created by separation...
  46. Lu X, Li W, Fukumoto S, Yamada Y, Evans C, DIEKWISCH T, et al. The ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing. Matrix Biol. 2016;52-54:113-126 pubmed publisher
    ..fracture healing, including cartilaginous callus formation, callus remodeling, and bony bridging of the fracture gap. In the present study we have defined the role of the extracellular matrix protein ameloblastin (AMBN) in fracture ..
  47. Harris K, Benoit G, Dionne J, Feber J, Cloutier L, Zarnke K, et al. Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, and Assessment of Risk of Pediatric Hypertension. Can J Cardiol. 2016;32:589-97 pubmed publisher
    ..Consequently, the present recommendations have been developed to address an important gap and improve the clinical care of children. For 2016, a total of 15 recommendations are presented...
  48. Ingram S, McKee G, Quirke M, Kelly N, Moloney A. Discharge of Non-Acute Coronary Syndrome Chest Pain Patients From Emergency Care to an Advanced Nurse Practitioner-Led Chest Pain Clinic: A Cross-Sectional Study of Referral Source and Final Diagnosis. J Cardiovasc Nurs. 2017;32:E1-E8 pubmed publisher
    ..The study fills a gap in the literature on the follow up of non-ACS patients who present to ED and used advanced cardiology nursing ..
  49. Accardo A, Finnegan E. Teaching reading comprehension to learners with autism spectrum disorder: Discrepancies between teacher and research-recommended practices. Autism. 2017;:1362361317730744 pubmed publisher
    ..effective practices, and the practices identified as effective through research, indicating a research to practice gap. Implications for practice include professional development recommendations, and the need for increased ..
  50. Ballesteros J, Hormiga G. Species delimitation of the North American orchard-spider Leucauge venusta (Walckenaer, 1841) (Araneae, Tetragnathidae). Mol Phylogenet Evol. 2018;121:183-197 pubmed publisher
    ..Guided by a preliminary observation of the barcode gap between sequences from specimens of L...
  51. Roth S, Fox H, Fuchs U, Schulz U, Costard Jäckle A, Gummert J, et al. Noninvasive pulse contour analysis for determination of cardiac output in patients with chronic heart failure. Clin Res Cardiol. 2018;107:395-404 pubmed publisher
    ..4%) for CO. With decreasing cardiac index, as determined by the gold standard of TD, there was an increasing gap between CO values obtained by TD and NPCA (r = - 0.75, p?<?0...
  52. Wu Y, Wu Q, Sun F, Cheng C, Meng S, Zhao J. Emergence of electron coherence and two-color all-optical switching in MoS2 based on spatial self-phase modulation. Proc Natl Acad Sci U S A. 2015;112:11800-5 pubmed publisher
    ..The gap-dependent nonlinear dielectric susceptibility χ(3) measured is surprisingly large, where direct interband ..
  53. Pan Q, Anderson J, Bertho S, Herpin A, Wilson C, Postlethwait J, et al. Vertebrate sex-determining genes play musical chairs. C R Biol. 2016;339:258-62 pubmed publisher
    ..To fill this knowledge gap and to better explore genetic sex-determination, we propose a strategy (RAD-Sex) that makes use of next-generation ..
  54. Sun L, Lu H, Chen H, Wang T, Ji X, Liu W, et al. Effects of Post Annealing Treatments on the Interfacial Chemical Properties and Band Alignment of AlN/Si Structure Prepared by Atomic Layer Deposition. Nanoscale Res Lett. 2017;12:102 pubmed publisher
    ..Specially, the Si-O-Al bonding state can be detected in the 900 °C-annealed sample. Furthermore, it is determined that the band gap and valence band offset increase with increasing annealing temperature.
  55. Koo J, Gao S, Lee H, Yang L. Vertical dielectric screening of few-layer van der Waals semiconductors. Nanoscale. 2017;9:14540-14547 pubmed publisher
    ..This conclusion is verified in a wide range of 2D paraelectric semiconductors, covering narrow-gap ones and wide-gap ones with different crystal symmetries, providing an efficient and reliable way to calculate and ..
  56. Skrzat J, Mroz I, Spulber A, Zarzecki M, Walocha J. Ossification of the petrosphenoid ligament - a case study. Folia Med Cracov. 2017;57:87-94 pubmed
    ..Both trabecula face each other but do not fuse, having a small gap between their tips...
  57. James C, Zeitz M, Calhoun P, Lamouille S, Smyth J. Altered translation initiation of Gja1 limits gap junction formation during epithelial-mesenchymal transition. Mol Biol Cell. 2018;: pubmed publisher
    ..Hallmarks of EMT are remodeling of intercellular junctions and adhesion proteins, including gap junctions...
  58. Loke M, Leung P. Quantifying food waste in Hawaii's food supply chain. Waste Manag Res. 2015;33:1076-83 pubmed publisher
    ..This article serves to explore that gap and aims to quantify the edible weight, economic value, and calorie equivalent of food waste in Hawaii...
  59. Wayman W, Chen L, Hu X, Napier T. HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016;41:1965-73 pubmed publisher
    ..To help fill this knowledge gap, electrophysiological assessments were made of mPFC pyramidal neurons (PN) from adult male HIV-1 transgenic (Tg) ..
  60. Lanoy C, Bouckaert Y. Metabolic acidosis and 5-oxoprolinuria induced by flucloxacillin and acetaminophen: a case report. J Med Case Rep. 2016;10:184 pubmed publisher
    Frequent causes of high anion gap metabolic acidosis are well known: ethanol, methanol, and ethylene glycol intoxication; hyperglycemia; lactic or D-lactic acidosis; and impaired renal function...
  61. Liang X, Zha J, Martyniuk C, Wang Z, Zhao J. Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure. Environ Pollut. 2017;229:459-469 pubmed publisher
    ..To address this knowledge gap, we measured the liver proteome of adult male Chinese rare minnow (Gobiocypris rarus) exposed to either 0.05, 0...
  62. Goel N, Alam A, Eggert E, Acharya S. Design and development of a customizable telemedicine platform for improving access to healthcare for underserved populations. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2658-2661 pubmed publisher
    Telemedicine offers a method to bridge the healthcare access gap in low and middle income countries (LMICs) by connecting providers with patients using appropriate technology...
  63. Sanz R, Clares B, Mallandrich M, Suñer Carbó J, Montes M, Calpena A. Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. Int J Pharm. 2018;535:393-401 pubmed publisher
    ..Therefore, we can hypostatize that the proposed formulation may assist to fill in the therapeutic gap regarding pure pain relief at local level in vagina.
  64. Kumar A, Sevilla M. SOMO-HOMO Level Inversion In Biologically Important Radicals. J Phys Chem B. 2017;: pubmed publisher
    ..localized spin density in ?-orbital on a single atom (carbon, nitrogen, oxygen, sulfur or selenium) the greater the gap between HOMO and SOMO...
  65. Chae S. Parental Divorce and Children's Schooling in Rural Malawi. Demography. 2016;53:1743-1770 pubmed
    ..Results show that parental divorce is associated with lower grade attainment and a larger schooling gap, defined as the number of years a child is behind in school (among children currently attending school)...
  66. Gilbert F, Cook M, O BRIEN T, Illes J. Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial. Sci Eng Ethics. 2019;25:83-96 pubmed publisher
    ..In this article, we address this knowledge gap by analysing data from the first-in-human clinical trial to study patients with implanted BCI advisory devices...
  67. Morris S, Naeve C, Mathew P, James P, Kirstein M, Cui X, et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene. 1997;14:2175-88 pubmed
    ..Thus, ALK is a novel orphan receptor tyrosine kinase that appears to play an important role in the normal development and function of the nervous system. ..
  68. Janssen A, Robinson T, Provan P, Shaw T. The Sydney West Knowledge Portal: Evaluating the Growth of a Knowledge Portal to Support Translational Research. J Med Internet Res. 2016;18:e170 pubmed publisher
    ..One solution to addressing this gap is the design and deployment of web-based knowledge portals to disseminate new knowledge and engage with and ..
  69. Henter H, Imondi R, James K, Spencer D, Steinke D. DNA barcoding in diverse educational settings: five case studies. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed publisher
    Despite 250 years of modern taxonomy, there remains a large biodiversity knowledge gap. Most species remain unknown to science...
  70. Torabinejad M, Nosrat A, Verma P, Udochukwu O. Regenerative Endodontic Treatment or Mineral Trioxide Aggregate Apical Plug in Teeth with Necrotic Pulps and Open Apices: A Systematic Review and Meta-analysis. J Endod. 2017;43:1806-1820 pubmed publisher
    ..Randomized multicenter clinical trials with large sample sizes and long-term follow-ups are needed to address this gap in knowledge.
  71. Liu P, PENA E. Sojourning with the Homogeneous Poisson Process. Am Stat. 2016;70:413-423 pubmed publisher
    ..Properties of the gap-time that covered the termination time and the correlations among gap-times of the observed events are obtained...
  72. Xu X, Wen X, Veltman D, Keizer Gunnink I, Pots H, Kortholt A, et al. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis. Proc Natl Acad Sci U S A. 2017;114:E10092-E10101 pubmed publisher
    ..We show that both C2 and GAP domains are required for the membrane targeting of C2GAP1, and that GPCR-triggered Ras activation is necessary to ..
  73. Shkir M, Alfaify S. Tailoring the structural, morphological, optical and dielectric properties of lead iodide through Nd3+ doping. Sci Rep. 2017;7:16091 pubmed publisher
    ..The energy band gap was calculated and found to be 3.35, 3.34, 3.42 and 3...
  74. Aguilar Palacio I, Carrera Lasfuentes P, Sánchez Recio R, Alonso J, Rabanaque M. Recession, employment and self-rated health: a study on the gender gap. Public Health. 2018;154:44-50 pubmed publisher
    ..economic recession in terms of self-rated health, its differential effect among genders and its influence on gender gap. Repeated cross-sectional study using Spanish health surveys (2001-2014)...
  75. Camomilla V, Cereatti A, Cutti A, Fantozzi S, Stagni R, Vannozzi G. Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review. Biomed Eng Online. 2017;16:106 pubmed publisher
    ..This article aims at filling this gap through a systematic review of the literature, conducted on Web of Science, Scopus and PubMed...
  76. Iyikanat F, Kandemir A, Ozaydin H, Senger R, Sahin H. Hydrogenation-driven phase transition in single-layer TiSe2. Nanotechnology. 2017;28:495709 pubmed publisher
    ..Fully hydrogenated TiSe2 presents a direct gap semiconducting behavior with a band gap of 119 meV...
  77. Márquez Luna C, Loh P, Price A. Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol. 2017;41:811-823 pubmed publisher
    ..Our work reduces the gap in polygenic risk prediction accuracy between European and non-European target populations.
  78. Wheat H, Goodwin A. Tactile discrimination of gaps by slowly adapting afferents: effects of population parameters and anisotropy in the fingerpad. J Neurophysiol. 2000;84:1430-44 pubmed
    ..We quantified the ability of humans to discriminate small differences in gap width using a forced-choice task...
  79. Rosapep L, Sanders E, Banke K. The influence of customer-medicine seller transactional dynamics on childhood diarrhoea management: a qualitative study in Ghana. Health Policy Plan. 2017;32:527-537 pubmed publisher
    ..In many countries, however, a significant knowledge-practice gap persists in appropriate diarrhoea management among private healthcare providers...
  80. Shafiq M, Naeem M, Munawar Z, Fatima I. Service Quality Assessment of Hospitals in Asian Context: An Empirical Evidence From Pakistan. Inquiry. 2017;54:46958017714664 pubmed publisher
    ..assurance were ranked first, second, third, fourth, and fifth, respectively, in terms of the size of the quality gap. The gaps were statistically significant, with values ?...
  81. Pelletier R, Akpovi C, Chen L, Vitale M. Cholesterol metabolism and Cx43, Cx46, Cx50 gap junction protein expression and localisation in normal and diabetic and obese ob/ob and db/db mouse testes. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00215.2017 pubmed publisher
    ..Our findings indicate that the db mutation-induced impairment of meiosis may arise from imbalances in cholesterol metabolism and upregulated Cx43 expression and phosphorylation in tubules. ..
  82. Wang Y, Duan T, Weng Z, Ling J, Yin X, Chen L, et al. Mild Periodic Acid Flux and Hydrothermal Methods for the Synthesis of Crystalline f-Element-Bearing Iodate Compounds. Inorg Chem. 2017;56:13041-13050 pubmed publisher
    ..features are observed in isotypic compounds 5-7, where 7 shows typical semiconductor behavior with a band gap of 2.43 eV. Remarkably, noncentrosymmetric 1, 6, and 7 exhibit strong second-harmonic-generation efficiencies of 1...
  83. Zhang X, Zhang X, Chen X. Happiness in the Air: How Does a Dirty Sky Affect Mental Health and Subjective Well-being?. J Environ Econ Manage. 2017;85:81-94 pubmed publisher
    ..This paper attempts to fill the gap by investigating the impact of air pollution on several key dimensions, including mental health status, depressive ..
  84. Zaugg L, Meyer S, Rohr N, Zehnder I, Zitzmann N. Fracture behavior, marginal gap width, and marginal quality of vented or pre-cemented CAD/CAM all-ceramic crowns luted on Y-TZP implants. Clin Oral Implants Res. 2018;29:175-184 pubmed publisher
    To investigate the fracture behavior and marginal gap region of CAD/CAM fabricated lithium disilicate (L) and zirconium dioxide (Z) crowns using palatal venting (PV), pre-cementation with custom analogs (CA), or conventional cementation ..
  85. Sullivan K, Evans D, Pandey A, Hraha T, Smith K, Markham N, et al. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation. Sci Rep. 2017;7:14818 pubmed publisher
    ..To address this knowledge gap, we employed proteomics approaches to analyze blood samples from 263 individuals, 165 of them with DS, leading to ..
  86. Zhou M, Zeng C, Song Y, Padelford J, Wang G, Sfeir M, et al. On the Non-Metallicity of 2.2?nm Au246 (SR)80 Nanoclusters. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..analysis of the oscillation suggests that it arises from the wavepacket motion on the ground state potential energy surface, which also indicates the presence of a small band-gap and thus non-metallic or molecular-like behaviour.
  87. Carey G, Dickinson H. A longitudinal study of the implementation experiences of the Australian National Disability Insurance Scheme: investigating transformative policy change. BMC Health Serv Res. 2017;17:570 pubmed publisher
    ..understanding of the Australian scheme and how individualised funding operates within this context, but will also generate much needed evidence that will have relevance to other jurisdictions and help fill a gap in the evidence base.
  88. Shen Y, Zhang S, Zhou J, Chen J. Cohort Research in "Omics" and Preventive Medicine. Adv Exp Med Biol. 2017;1005:193-220 pubmed publisher
    ..Cohort study can bridge the gap between the micro and macro research.This chapter is divided into three parts: 1...
  89. Ketrat S, Maihom T, Wannakao S, Probst M, Nokbin S, Limtrakul J. Coordinatively Unsaturated Metal-Organic Frameworks M3(btc)2 (M = Cr, Fe, Co, Ni, Cu, and Zn) Catalyzing the Oxidation of CO by N2O: Insight from DFT Calculations. Inorg Chem. 2017;56:14005-14012 pubmed publisher
    ..This, in turn, is due to the smaller gap between the highest occupied molecular orbital (HOMO) of the MOF and the lowest unoccupied molecular orbital (LUMO)..
  90. Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom J, Kume T. Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes. Stem Cells. 2016;34:1487-500 pubmed publisher
    ..pathways regulated by Foxc1 involved in cardiac function including actin cytoskeleton, cell adhesion, tight and gap junctions, and calcium signaling...
  91. de Abreu E Lima F, Westhues M, Cuadros Inostroza A, Willmitzer L, Melchinger A, Nikoloski Z. Metabolic robustness in young roots underpins a predictive model of maize hybrid performance in the field. Plant J. 2017;90:319-329 pubmed publisher
    ..Therefore, our findings demonstrated the potential of metabolic profiles from young maize roots grown under tightly controlled conditions to predict hybrid performance in multiple field trials, thus bridging the greenhouse-field gap.
  92. Gao L, Feng S, Liu Z, Wang J, Qi K, Wang K. A computational network analysis based on targets of antipsychotic agents. Schizophr Res. 2018;193:154-160 pubmed publisher
    ..networks related with drug metabolism, Calcium signaling, GABA receptors, dopamine receptors, Bile secretion and Gap junction...