Gene Symbol: RARB
Description: retinoic acid receptor beta
Alias: HAP, MCOPS12, NR1B2, RARbeta1, RRB2, retinoic acid receptor beta, HBV-activated protein, RAR-beta, RAR-epsilon, hepatitis B virus activated protein, nuclear receptor subfamily 1 group B member 2, retinoic acid receptor, beta polypeptide
Species: human
Products:     RARB

Top Publications

  1. Houle B, Pelletier M, Wu J, Goodyer C, Bradley W. Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines. Cancer Res. 1994;54:365-9 pubmed
    The retinoic acid receptor type beta (RAR beta) complementary DNA from a small cell tumor line was amplified, sequenced, and found to be homologous to the murine RAR beta 1. Seventeen lung tumor lines were analyzed...
  2. Peng X, Maruo T, Cao Y, Punj V, Mehta R, Das Gupta T, et al. A novel RARbeta isoform directed by a distinct promoter P3 and mediated by retinoic acid in breast cancer cells. Cancer Res. 2004;64:8911-8 pubmed
    ..In conclusion, we identified and initially characterized RARbeta5 in normal, premalignant, and malignant breast epithelial cells. RARbeta5 may serve as a potential target of retinoids in prevention and therapy studies. ..
  3. De The H, Vivanco Ruiz M, Tiollais P, Stunnenberg H, Dejean A. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature. 1990;343:177-80 pubmed
    ..We have previously shown that the retinoic acid receptor beta gene is transcriptionally up-regulated by retinoic acid and now report the characterization of a ..
  4. Brand N, Petkovich M, Krust A, Chambon P, De The H, Marchio A, et al. Identification of a second human retinoic acid receptor. Nature. 1988;332:850-3 pubmed
    ..This novel protein (hap for hepatoma) exhibits strong homology with the human retinoic acid receptor (RAR) which has been recently ..
  5. Sommer K, Chen L, Treuting P, Smith L, Swisshelm K. Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc Natl Acad Sci U S A. 1999;96:8651-6 pubmed
    The transcription factor retinoic acid receptor beta(2) (RARbeta(2)) is a potent inhibitor of breast cancer cells in vitro, and studies suggest that RARbeta expression is lost in primary breast cancer...
  6. Hayashi K, Goodison S, Urquidi V, Tarin D, Lotan R, Tahara E. Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4. Int J Oncol. 2003;22:623-9 pubmed
    The human retinoic acid receptor beta (RARbeta) has three isoforms (beta1, beta2, and beta4), which play important, distinct roles in mediating the effects of retinoic acid on cell growth and apoptosis...
  7. Jeronimo C, Henrique R, Hoque M, Ribeiro F, Oliveira J, Fonseca D, et al. Quantitative RARbeta2 hypermethylation: a promising prostate cancer marker. Clin Cancer Res. 2004;10:4010-4 pubmed
    ..30, P = 0.0009). This quantitative assay represents a novel and promising molecular marker that may augment current approaches for prostate cancer detection. ..
  8. Swift M, Wallden B, Wayner E, Swisshelm K. Truncated RAR beta isoform enhances proliferation and retinoid resistance. J Cell Physiol. 2006;209:718-25 pubmed
    We previously reported the existence of a truncated isoform of the retinoic acid receptor beta, termed beta prime. Beta prime lacks the N-terminal domains of beta 2 and beta 4, including the DNA-binding domain...
  9. Benbrook D, Lernhardt E, Pfahl M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature. 1988;333:669-72 pubmed
    ..Activation by this virus may play a role in tumour development in liver cells, where it is normally not expressed. ..

More Information

Publications105 found, 100 shown here

  1. Baust C, Redpath L, Schwarz E. Different ligand responsiveness of human retinoic-acid-receptor beta-gene transcription in tumorigenic and non-tumorigenic cervical-carcinoma-derived cell lines is mediated through a large retinoic-acid-response domain. Int J Cancer. 1996;67:409-16 pubmed
    ..The communication between the upstream elements and the beta RARE seems to be disturbed in HeLa cells. Similar defects may be responsible for the loss of RA responsiveness of RAR-beta gene expression in other human tumors. ..
  2. Hauksdottir H, Farboud B, Privalsky M. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol Endocrinol. 2003;17:373-85 pubmed
  3. Zhuang Y, Faria T, Chambon P, Gudas L. Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. Mol Cancer Res. 2003;1:619-30 pubmed
    ..Because the lack of RARbeta(2) alters both the control of proliferation and differentiation in F9 cells, the genes that we have characterized may mediate key effects of RA, via RARbeta(2), on these processes...
  4. Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Mol Cell Biol. 2005;25:10591-603 pubmed
    ..This report provides proof of principle that RARbeta2 silencing and RA resistance are consequent to an impaired integration of RA signal at RARbeta2 chromatin. ..
  5. Petty W, Li N, Biddle A, Bounds R, Nitkin C, Ma Y, et al. A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis. J Natl Cancer Inst. 2005;97:1645-51 pubmed
    ..The expression, transcriptional activity, and growth suppressive activity of RARbeta1', a novel RAR isoform, were evaluated in lung cancer cells transfected with RARbeta1', and expression was also ..
  6. Feng Q, Hawes S, Stern J, Wiens L, Lu H, Dong Z, et al. DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2008;17:645-54 pubmed publisher
    ..Seven genes (RARB, BVES, CDKN2A, KCNH5, RASSF1, CDH13, and RUNX) were found to be methylated significantly more frequently in tumor ..
  7. Mattei M, De The H, Mattei J, Marchio A, Tiollais P, Dejean A. Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3. Hum Genet. 1988;80:189-90 pubmed
    The human hap retinoic acid receptor RAR beta has been localized by in situ hybridization to the p24 band of chromosome 3.
  8. Toulouse A, Morin J, Pelletier M, Bradley W. Structure of the human retinoic acid receptor beta 1 gene. Biochim Biophys Acta. 1996;1309:1-4 pubmed
    We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers...
  9. Chen L, Sommer K, Swisshelm K. Downstream codons in the retinoic acid receptor beta -2 and beta -4 mRNAs initiate translation of a protein isoform that disrupts retinoid-activated transcription. J Biol Chem. 2002;277:35411-21 pubmed
    ..This repression required the presence of acidic amino acids within the AF2 domain. These findings demonstrate an antagonistic role for RARbeta' in signaling by retinoic acid. ..
  10. Nagpal S, Zelent A, Chambon P. RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. Proc Natl Acad Sci U S A. 1992;89:2718-22 pubmed
    An isoform of retinoic acid receptor beta, RAR-beta 4, has been identified. RAR-beta 4 is expressed under the control of the same retinoic acid-responsive promoter as RAR-beta 2...
  11. De The H, Marchio A, Tiollais P, Dejean A. Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J. 1989;8:429-33 pubmed
    ..In addition, treatment of human hepatoma cells with RA leads to a rapid 10- to 50-fold increase in RAR beta mRNA levels, whereas RAR alpha mRNA expression is not affected...
  12. Sirchia S, Ren M, Pili R, Sironi E, Somenzi G, Ghidoni R, et al. Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res. 2002;62:2455-61 pubmed
    ..This study may have translational implications for breast cancer and other cancers carrying an epigenetically silenced RARbeta P2 promoter. ..
  13. Kafienah W, Mistry S, Perry M, Politopoulou G, Hollander A. Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor. Stem Cells. 2007;25:2460-8 pubmed
    ..In this way, we identified retinoic acid receptor beta (RAR beta) as a potential pharmacological target...
  14. Zhang C, Jin Y, Xu H, Zhang H, Zhang W, Sun X, et al. [Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011;28:23-8 pubmed publisher
    ..effects of promoter methylation of p16, death-associated protein kinase (DAPK) and retinoic acid receptor-beta (RAR beta) genes on clinical data in non-small cell lung cancers, and to study the effect of smoking on the risk of gene ..
  15. Moison C, Senamaud Beaufort C, Fourrière L, Champion C, Ceccaldi A, Lacomme S, et al. DNA methylation associated with polycomb repression in retinoic acid receptor ? silencing. FASEB J. 2013;27:1468-78 pubmed publisher
  16. Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, et al. LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae. MBio. 2015;6:e02575 pubmed publisher
    ..and Skp, and an accumulation of β-barrel-containing outer membrane proteins comprising the autotransporters Hap, IgA serine protease, and HMW2A, as observed by proteomic analysis...
  17. Zhao C, Chen H, Wang H, Liu W, Zhuo C, Chu Y, et al. [Analysis of pathogen spectrum and resistance of clinical common organisms causing bloodstream infections, hospital-acquired pneumonia and intra-abdominal infections from thirteen teaching hospitals in 2013]. Zhonghua Yi Xue Za Zhi. 2015;95:1739-46 pubmed
    ..Nosocomial cases as well as pathogens causing bloodstream infections (BSI), hospital-acquired pneumonia (HAP) and intra-abdominal infections (IAI) from 13 teaching hospital around China were collected...
  18. Weinstein A, Escheik C, Oe B, Price J, Gerber L, Younossi Z. Perception of Effort During Activity in Patients With Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease. PM R. 2016;8:28-34 pubmed publisher
    ..RPE, 6MWT, resting/postexertion cardiorespiratory data (eg, heart rate, cardiac output), Human Activity Profile (HAP), fasting morning glucose (GLU), total cholesterol (TC), lipids, and interleukin-8 (IL-8) were determined...
  19. Htoutou Sedlakova M, Pudova V, Kolar M. [Bacterial pathogens causing hospital-acquired pneumonia - a multicenter study in the Czech Republic]. Klin Mikrobiol Infekc Lek. 2015;21:10-4 pubmed
    The objectives were to assess the prevalence of etiologic agents of hospital-acquired pneumonia (HAP) in patients staying in four big hospitals in the Czech Republic and requiring artificial ventilation...
  20. Callahan C, Bonner M, Nie J, Han D, Wang Y, Tao M, et al. Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. Environ Res. 2018;161:418-424 pubmed publisher
    ..Methylation of nine genes (SFN, SCGB3A1, RARB, GSTP1, CDKN2A CCND2, BRCA1, FHIT, and SYK) was assessed using bisulfite-based pyrosequencing...
  21. Arku R, Ezzati M, Baumgartner J, Fink G, Zhou B, Hystad P, et al. Elevated blood pressure and household solid fuel use in premenopausal women: Analysis of 12 Demographic and Health Surveys (DHS) from 10 countries. Environ Res. 2018;160:499-505 pubmed publisher
    Approximately three billion people are exposed to household air pollution (HAP) from solid fuel cookstoves...
  22. Plitzko B, Havemeyer A, Kunze T, Clement B. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015;290:10126-35 pubmed publisher
    N-Hydroxylated nucleobases and nucleosides as N-hydroxylaminopurine (HAP) or N-hydroxyadenosine (HAPR) may be generated endogenously in the course of cell metabolism by cytochrome P450, by oxidative stress or by a deviating nucleotide ..
  23. Wu S, Zhao Q, Zhang P, Kulp J, Hu L, Hwang N, et al. Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly. J Virol. 2017;91: pubmed publisher
    ..suggested that both SBAs and BAs inhibited HBV nucleocapsid assembly by binding to the heteroaryldihydropyrimidine (HAP) pocket between core protein dimer-dimer interfaces...
  24. Fang J, Wei H, Zheng Z, Liu J, Hu B, Huang J. [Expression and its significance of retinoic acid receptor-beta in colorectal cancer]. Zhonghua Wai Ke Za Zhi. 2010;48:134-7 pubmed
    ..The expression level of RAR-beta may be a new prognostic indication of patients with colorectal cancer. ..
  25. Anand S, Kaysen G, Chertow G, Johansen K, Grimes B, Dalrymple L, et al. Vitamin D deficiency, self-reported physical activity and health-related quality of life: the Comprehensive Dialysis Study. Nephrol Dial Transplant. 2011;26:3683-8 pubmed publisher
    ..Physical activity was measured with the Human Activity Profile (HAP); the Medical Outcomes Study Short Form-12 (SF-12) was employed to measure HRQoL...
  26. Gao T, He B, Pan Y, Li R, Xu Y, Chen L, et al. The association of retinoic acid receptor beta2(RARβ2) methylation status and prostate cancer risk: a systematic review and meta-analysis. PLoS ONE. 2013;8:e62950 pubmed publisher
    ..The detection of RARβ2 methylation in urine or serum is a potential non-invasive diagnostic tool in prostate cancer. The present findings also require confirmation through adequately designed prospective studies. ..
  27. Gu J, Chen Q, Xiao X, Ito F, Wolfe A, Chen X. Biochemical Characterization of APOBEC3H Variants: Implications for Their HIV-1 Restriction Activity and mC Modification. J Mol Biol. 2016;428:4626-4638 pubmed publisher
    APOBEC3H (A3H) is the most polymorphic member of the APOBEC3 family. Seven haplotypes (hap I-VII) and four mRNA splicing variants (SV) of A3H have been identified...
  28. Shin A, Shin B, Shin J, Kim K, Atwal R, Hope J, et al. Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels. Hum Mol Genet. 2017;26:1258-1267 pubmed publisher
    ..e. hap.01) on the mutant chromosome...
  29. Li W, Liao P, Oldham T, Jiang Y, Pan C, Yuan S, et al. Real-time evaluation of natural organic matter deposition processes onto model environmental surfaces. Water Res. 2018;129:231-239 pubmed publisher
    ..Rapid, near-monolayer formation of SRHA/SRFA adlayers were observed on Al2O3, hydroxyapatite (HAP), and poly (l-lysine) (PLL) surfaces, but not on PS or iron oxide (Fe3O4) surfaces...
  30. Sassoni E, D Amen E, Roveri N, Scherer G, Franzoni E. Durable Self-Cleaning Coatings for Architectural Surfaces by Incorporation of TiOâ‚‚ Nano-Particles into Hydroxyapatite Films. Materials (Basel). 2018;11: pubmed publisher
    ..Here, we investigated the combination of nano-TiOâ‚‚ and hydroxyapatite (HAP), previously developed for marble protection against dissolution in rain and mechanical consolidation...
  31. Tsiourvas D, Tsetsekou A, Kammenou M, Boukos N. Biomimetic synthesis of ribbon-like hydroxyapatite employing poly(l-arginine). Mater Sci Eng C Mater Biol Appl. 2016;58:1225-31 pubmed publisher
    ..It was found that the presence of PA promotes HAP formation and affects its crystal size and morphology possibly through a rather specific interaction between the ..
  32. Jegatheeswaran S, Selvam S, Sri Ramkumar V, Sundrarajan M. Novel strategy for f-HAp/PVP/Ag nanocomposite synthesis from fluoro based ionic liquid assistance: Systematic investigations on its antibacterial and cytotoxicity behaviors. Mater Sci Eng C Mater Biol Appl. 2016;67:8-19 pubmed publisher
    A novel biomimetic f-HAp/PVP/Ag nanocomposite was synthesized under the ionic liquid medium, which was composed of inorganic and organic nanofillers like fluor-hydroxyapatite, silver nanoparticles and polyvinyl pyrrolidone...
  33. Ferrone V, Carlucci M, Cotellese R, Raimondi P, Cichella A, Marco L, et al. Development and validation of a fast micro-extraction by packed sorbent UHPLC-PDA method for the simultaneous determination of linezolid and ciprofloxacin in human plasma from patients with hospital-acquired pneumonia. Talanta. 2017;164:64-68 pubmed publisher
    ..quantification of linezolid and ciprofloxacin in human plasma and applied in hospital acquired pneumonia patients (HAP). The method uses a semi-automated microextraction by packed sorbent for sample preparation...
  34. Iconaru S, Prodan A, Buton N, Predoi D. Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings. Molecules. 2017;22: pubmed publisher
    ..study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings...
  35. Pulyala P, Singh A, Dias Netipanyj M, Cogo S, Santos L, Soares P, et al. In-vitro cell adhesion and proliferation of adipose derived stem cell on hydroxyapatite composite surfaces. Mater Sci Eng C Mater Biol Appl. 2017;75:1305-1316 pubmed publisher
    The goal of this work was to enhance the mechanical strength and fracture toughness of brittle hydroxyapatite (HAP) by reinforcing it with nanocomposites such as graphene oxide (GO), carbon nanotubes (CNT) and Titania...
  36. Kanazawa M, Tsuru K, Fukuda N, Sakemi Y, Nakashima Y, Ishikawa K. Evaluation of carbonate apatite blocks fabricated from dicalcium phosphate dihydrate blocks for reconstruction of rabbit femoral and tibial defects. J Mater Sci Mater Med. 2017;28:85 pubmed publisher
    ..blocks were used to reconstruct defects in the femur and tibia of rabbits, using sintered dense hydroxyapatite (HAp) blocks as the control...
  37. Nakayama M, Kajiyama S, Kumamoto A, Nishimura T, Ikuhara Y, Yamato M, et al. Stimuli-responsive hydroxyapatite liquid crystal with macroscopically controllable ordering and magneto-optical functions. Nat Commun. 2018;9:568 pubmed publisher
    ..Here we report the development of liquid-crystalline (LC) hydroxyapatite (HAp), which is an environmentally friendly and biocompatible biomineral...
  38. Sun J, Xu X, Liu J, Liu H, Fu L, Gu L. Epigenetic regulation of retinoic acid receptor ?2 gene in the initiation of breast cancer. Med Oncol. 2011;28:1311-8 pubmed publisher
    In order to investigate the methylation status of the retinoic acid receptor beta 2 gene (RAR-?2) in breast carcinoma in relation to gene expression and clinicopathological parameters of patients with breast cancer, expression of RAR-?2 ..
  39. Kozmin S, Schaaper R. Genetic characterization of moaB mutants of Escherichia coli. Res Microbiol. 2013;164:689-94 pubmed publisher
    ..diagnostic for Moco-deficiency: chlorate-resistance and sensitivity to the base analog 6-N-hydroxylaminopurine (HAP)...
  40. Grineski S, Collins T, Morales D. Asian Americans and disproportionate exposure to carcinogenic hazardous air pollutants: A national study. Soc Sci Med. 2017;185:71-80 pubmed publisher
    ..The aggregated Asian category ranks just below Blacks and above Hispanics, in terms of carcinogenic HAP risk...
  41. Shu R, He J, Wu C, Gao J. The association between RAR? and FHIT promoter methylation and the carcinogenesis of patients with cervical carcinoma: A meta-analysis. Tumour Biol. 2017;39:1010428317709126 pubmed publisher
    ..FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings. ..
  42. Buyuksungur S, Endogan Tanir T, Buyuksungur A, Bektas E, Torun Köse G, Yucel D, et al. 3D printed poly(?-caprolactone) scaffolds modified with hydroxyapatite and poly(propylene fumarate) and their effects on the healing of rabbit femur defects. Biomater Sci. 2017;5:2144-2158 pubmed publisher
    ..disks of poly(?-caprolactone) (PCL) were printed by fused deposition modeling and modified with nanohydroxyapatite (HAp) and poly(propylene fumarate) (PPF) to create a mechanically strong implant with well-defined pore size and ..
  43. Grădinaru S, Popescu L, Piticescu R, Zurac S, Ciuluvica R, Burlacu A, et al. Repair of the Orbital Wall Fractures in Rabbit Animal Model Using Nanostructured Hydroxyapatite-Based Implant. Nanomaterials (Basel). 2016;6: pubmed publisher
    ..X-ray diffraction revealed HAp crystallites of 21 nm, while Scanning Electron Microscopy (SEM) images showed spherical shapes of HAp powder...
  44. Mohsenzadeh M, Sadeghi R, Vahedi M, Kamani F, Hashemi M, Asadzadeh H, et al. Promoter hypermethylation of RAR-β tumor suppressor gene in gastric carcinoma: Association with histological type and clinical outcomes. Cancer Biomark. 2017;20:7-15 pubmed publisher
  45. Wu G, Deng X, Song J, Chen F. Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration. J Photochem Photobiol B. 2018;178:27-32 pubmed publisher
    ..The fine fibrous morphology of the nanostructured hydroxyapatite (HAp) dispersed in the polycaprolactone/chitosan (HAp-PCL/CS) nanofibrous matrix was exhibited by microscopic (SEM and ..
  46. Haynes J, McKee T, Haller A, Wang Y, Leung C, Gendoo D, et al. Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer. Clin Cancer Res. 2018;24:2116-2127 pubmed publisher
    ..Patient-derived colorectal cancer xenografts were treated with evofosfamide, a hypoxia-activated prodrug (HAP), in combination with 5-fluorouracil (5-FU) or chemoradiotherapy (5-FU and radiation; CRT)...
  47. Fackler M, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak K, et al. DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer. 2003;107:970-5 pubmed
    ..These results suggest that these 2 types of tumors share many common methylation patterns and some molecular differences. Additional studies might lend further understanding into the etiology and clinical behavior of this tumor type. ..
  48. Collins S, Lucas J, Inskip H, Godfrey K, Roberts G, Holloway J. HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function. Eur Respir J. 2013;41:756-7 pubmed publisher
  49. Massera J, Kokkari A, Närhi T, Hupa L. The influence of SrO and CaO in silicate and phosphate bioactive glasses on human gingival fibroblasts. J Mater Sci Mater Med. 2015;26:196 pubmed publisher
    ..The layer at the surface of the silicate glass consisted of HAP whereas at the phosphate glasses it was close to the DCPD composition...
  50. Pitiot V, Hermann R, Tringali S, Dubreuil C, Truy E. Revision stapes surgery for lysis of the long process of the incus: comparing hydroxyapatite bone cement versus malleovestibulopexy and total ossicular replacement prosthesis. Eur Arch Otorhinolaryngol. 2016;273:2515-21 pubmed publisher
    The objective of the study was to report audiological results in revision stapes surgery, comparing hydroxyapatite (HAP) bone cement, malleovestibular (MV) prosthesis, and total ossicular replacement prosthesis (TORP)...
  51. Ren H, Chen B, Huang G, Liu Y, Shen D. Upregulation of retinoic acid receptor-? reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosis. Mol Med Rep. 2016;14:3602-8 pubmed publisher
    ..These results support the hypothesis that RAR? may be an ideal chemosensitization target for the treatment of patients with drug-resistant CCA. ..
  52. Stenlund M, Sjödahl R, Pia Yngman Uhlin R. Incidence and potential risk factors for hospital-acquired pneumonia in an emergency department of surgery. Int J Qual Health Care. 2017;29:290-294 pubmed publisher
    Hospital-acquired pneumonia (HAP) is associated with high mortality and is the second most common nosocomial infection...
  53. Ribeiro C, Martins M, Bressiani A, Bressiani J, Leyva M, de Queiroz A. Electrochemical preparation and characterization of PNIPAM-HAp scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017;81:156-166 pubmed publisher
    ..ECP as scaffold fabrication technique to produce highly porous poly(N-isopropylacrylamide) (PNIPAM)/hydroxyapatite (HAp) composite for bone tissue regeneration...
  54. Skrickova J. [Nosocomial pneumonia]. Vnitr Lek. 2017;63:518-526 pubmed
    Nosocomial pneumonia (hospital-acquired pneumonia - HAP) is the form of pneumonia the symptoms of which present after more than 2 days (> 48 hours) of admission to hospital or as late as 14 days of discharge from hospital...
  55. Thompson L, Diaz Artiga A, Weinstein J, Handley M. Designing a behavioral intervention using the COM-B model and the theoretical domains framework to promote gas stove use in rural Guatemala: a formative research study. BMC Public Health. 2018;18:253 pubmed publisher
    ..Class attendance rates were above 92%. We discussed feasible ways to reduce HAP exposure, proper stove use, maintenance and safety...
  56. Zhao J, Zhang Z, Vucetic Z, Soprano K, Soprano D. HACE1: A novel repressor of RAR transcriptional activity. J Cell Biochem. 2009;107:482-93 pubmed publisher
    ..On the other hand, HACE1 inhibits the RA dependent degradation of RARbeta(3). It is possible that the repression of RAR-regulated transcription by HACE1 is due to its ability to inhibit the RA-dependent degradation of RARs. ..
  57. Tabatabaee Bafroee A, Siadat S, Mousavi S, Aghasadeghi M, Khorsand H, Nejati M, et al. Recombinant C-terminal 311 amino acids of HapS adhesin as a vaccine candidate for nontypeable Haemophilus influenzae: A study on immunoreactivity in Balb/C mouse. Microb Pathog. 2016;98:106-11 pubmed publisher
    b>Hap, an auto-transporter protein, is an antigenically conserved adhesion protein which is present on both typeable and nontypeable Haemophilus influenzae...
  58. Souli M, Karaiskos I, Masgala A, Galani L, Barmpouti E, Giamarellou H. Double-carbapenem combination as salvage therapy for untreatable infections by KPC-2-producing Klebsiella pneumoniae. Eur J Clin Microbiol Infect Dis. 2017;36:1305-1315 pubmed publisher
    ..secondary bacteraemia (four and 12 respectively), primary (six) or catheter-related bloodstream infections (two), HAP or VAP (two) and external ventricular drainage infection (one) were treated exclusively with ertapenem and high-..
  59. Kammerer S, Germain P, Flaig R, Peluso Iltis C, Mitschler A, Rochel N, et al. RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis. Acta Crystallogr D Biol Crystallogr. 2004;60:2048-50 pubmed
    ..The unit-cell parameters are a = 47.81, b = 58.52, c = 92.83 A for the TTNPB-hRARbeta LBD crystal and a = 58.14, b = 84.07, c = 102.37 A when the SRC-1 peptide is also bound. ..
  60. Petit P, Bicout D, Persoons R, Bonneterre V, Barbeau D, Maitre A. Constructing a Database of Similar Exposure Groups: The Application of the Exporisq-HAP Database from 1995 to 2015. Ann Work Expo Health. 2017;61:440-456 pubmed publisher
    ..Similar exposure groups (SEGs) are needed to reliably assess occupational exposures and health risks. However, the construction of SEGs can turn out to be rather challenging because of the multifactorial variability of exposures...
  61. Predoi D, Predoi M, Iconaru S, Ech Cherif El Kettani M, Leduc D, Prodan A. Ultrasonic Measurements on ? Cyclodextrin/Hydroxyapatite Composites for Potential Water Depollution. Materials (Basel). 2017;10: pubmed publisher
    ..structural, morphological and preliminary ultrasonic characterizations of the ?-Cyclodextrin/hydroxyapatite (CD-HAp) composites synthesized by an adapted co-precipitation method...
  62. Uma Maheshwari S, Govindan K, Raja M, Raja A, Pravin M, Vasanth Kumar S. Preliminary studies of PVA/PVP blends incorporated with HAp and ?-TCP bone ceramic as template for hard tissue engineering. Biomed Mater Eng. 2017;28:401-415 pubmed publisher
    Polyvinylalcohol (PVA) and Polyvinylpyrrolidone (PVP) blend incorporated with hydroxyapatite (HAp) and ?-tricalcium phosphate (?-TCP) is electrospun as nanofibrous composite scaffolds to act as suitable template for bone tissue ..
  63. Song Z, Liu Y, Shi J, Ma T, Zhang Z, Ma H, et al. Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform. Mater Sci Eng C Mater Biol Appl. 2018;83:90-98 pubmed publisher
    In this study, gold nanorods/mesoporous silica/hydroxyapatite (Au/SiO2/HAP) hybrid nanoparticles with AuNR core and SiO2/HAP hybrid inorganic shell for multi-responsive drug delivery had been prepared...
  64. Chen R, Yin X, Chen F. [The role of exogenous hRAR beta gene on the growth inhibition and differentiation induction of HL-60R Cells]. Zhonghua Xue Ye Xue Za Zhi. 2001;22:524-7 pubmed
    ..In the presence of RAR-selected agonist Ch55, the effect of RAR beta gene on HL-60R was studied by the efficiency of colony formation in soft agar, cell morphology NBT reduction ..
  65. Tan C, Jin Y, Xu H, Zhang C, Zhang H, Zhang W, et al. [Correlation between RARbeta gene promoter methylation and P53 gene mutations in non-small cell lung cancer]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:131-6 pubmed publisher
    ..480, 95%CI: 1.400-21.446) or patients with advanced tumors (OR=3.446, 95%CI: 1.054-11.267) after adjusting for age and sex. RARbeta methylation is associated with G:C>T:A mutations in P53 gene in NSCLC. ..
  66. Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart C, et al. Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies. Antioxid Redox Signal. 2018;28:131-140 pubmed publisher
    Evofosfamide (TH-302) is a hypoxia-activated prodrug (HAP) that releases the DNA-damaging bromo-isophosphoramide mustard (Br-IPM) moiety selectively under hypoxic conditions...
  67. Chiu S, Shinonaga Y, Abe Y, Harada K, Arita K. Influence of Porous Spherical-Shaped Hydroxyapatite on Mechanical Strength and Bioactive Function of Conventional Glass Ionomer Cement. Materials (Basel). 2017;10: pubmed publisher
    ..The aim of this study is to investigate the mechanisms by which hydroxyapatite (HAp) improves the mechanical strength and bioactive functioning of GIC when these materials are combined to make ..
  68. Renaudin G, Gomes S, Nedelec J. First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study. Materials (Basel). 2017;10: pubmed publisher
    ..the biological environment, whereas higher sintering temperatures locate the doping elements in the weakly soluble HAp phase, enabling a slow and continuous supply of the bio-inspired properties...
  69. Hassanali L, Wong F, Lynch R, Anderson P. A Novel Kinetic Method to Measure Apparent Solubility Product of Bulk Human Enamel. Front Physiol. 2017;8:714 pubmed publisher
    ..these conditions was higher than many previous reported values, and much closer to those previously reported for HAp. However, this is a bulk value, and does not reflect that enamel is a heterogeneous material, nor the influence of ..
  70. Uvizl R, Herkel T, Langova K, Jakubec P. Management of mechanical ventilation in patients with hospital-acquired pneumonia: A retrospective, observational study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017;: pubmed publisher
    Hospital-acquired pneumonia (HAP) in intensive care patients is a frequent reason for mechanical ventilation (MV). The management of MV and ventilator weaning vary, depending on the type of lung inflammation...
  71. Cao L, Xiao Y, Lu W, Liu S, Gan L, Yu J, et al. Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers. J Biomater Appl. 2017;:885328217741522 pubmed publisher
    ..Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide)...
  72. Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995;9:769-82 pubmed
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways. ..
  73. Farboud B, Hauksdottir H, Wu Y, Privalsky M. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol. 2003;23:2844-58 pubmed
    ..RAR alpha strongly interacts with SMRT and can repress target gene transcription, whereas RAR beta and -gamma interact with SMRT only weakly and fail to repress...
  74. Klein O, Grignon Y, Civit T, Auque J, Marchal J. [Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 . Neurochirurgie. 2005;51:147-54 pubmed
    b>Retinoic acid receptor beta (RARbeta) is a nuclear receptor often deregulated in tumors...
  75. Huang S, Laoukili J, Epping M, Koster J, Hölzel M, Westerman B, et al. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009;15:328-40 pubmed publisher
    ..Finally, we show that low ZNF423 expression is associated with poor disease outcome in neuroblastoma patients. ..
  76. Chandra V, Wu D, Li S, Potluri N, Kim Y, Rastinejad F. The quaternary architecture of RAR?-RXR? heterodimer facilitates domain-domain signal transmission. Nat Commun. 2017;8:868 pubmed publisher
    ..Here the authors present the crystal structure of the retinoic acid receptor ?-retinoic X receptor ? (RAR?-RXR?) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures are variable. ..
  77. Liu W, Hellman P, Li Q, Yu W, Juhlin C, Nordlinder H, et al. Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells. Biochem Biophys Res Commun. 1996;229:922-9 pubmed
    ..The present data establish parathyroid gland as a target for retinoids and as a site of synthesis of the hormonal forms of vitamin A (retinol), all-trans- and 9-cis-retinoic acid. ..
  78. Ponomaryova A, Rykova E, Cherdyntseva N, Skvortsova T, Dobrodeev A, Zav yalov A, et al. RAR?2 gene methylation level in the circulating DNA from blood of patients with lung cancer. Eur J Cancer Prev. 2011;20:453-5 pubmed publisher
    ..The data obtained indicate that cirDNA-based testing provides a valuable source for subsequent verification of methylated DNA markers for lung cancer diagnostics and prognosis. ..
  79. Bhagat R, Kumar S, Vaderhobli S, Premalata C, Pallavi V, Ramesh G, et al. Epigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma. Tumour Biol. 2014;35:9069-78 pubmed publisher
    ..Our results suggest that epigenetic alterations of p16 and RAR-? have an important role in ovarian carcinogenesis and that mechanism along with methylation plays a significant role in downregulation of RAR-? gene in ovarian cancer. ..
  80. Li H, Wu D, Wu J, Dong L, Zhu Y, Hu X. Flexible, High-Wettability and Fire-Resistant Separators Based on Hydroxyapatite Nanowires for Advanced Lithium-Ion Batteries. Adv Mater. 2017;29: pubmed publisher
    ..Herein, a novel kind of highly flexible and porous separator based on hydroxyapatite nanowires (HAP NWs) with excellent thermal stability, fire resistance, and superior electrolyte wettability is reported...
  81. Fukao K, Nonoyama T, Kiyama R, Furusawa K, Kurokawa T, Nakajima T, et al. Anisotropic Growth of Hydroxyapatite in Stretched Double Network Hydrogel. ACS Nano. 2017;: pubmed publisher
    ..mimic such an anisotropic structure of natural organic/inorganic hybrid materials, we carried out hydroxyapatite (HAp) mineralization in stretched tough double network (DN) hydrogels...
  82. David N, Nallaiyan R. Biologically anchored chitosan/gelatin-SrHAP scaffold fabricated on Titanium against chronic osteomyelitis infection. Int J Biol Macromol. 2018;110:206-214 pubmed publisher
    ..Interconnected porous morphology of the scaffolds was confirmed, besides the globular Sr-HAP found in HV2 scaffold...
  83. Ishii H, Tezuka T, Ishikawa H, Takada K, Oida K, Horie S. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the T. Blood. 2003;101:4765-74 pubmed
  84. Lu T, Li W, Li X, Wang L, Wang R, Zhang L, et al. [The relationship between retinoic acid receptor-? expression and chemotherapy response in esophageal squamous cell carcinoma]. Zhonghua Nei Ke Za Zhi. 2010;49:848-50 pubmed
    ..05). RAR-? protein expression by immunohistochemistry may be a useful indicator to predict the chemotherapy response and clinical outcome for ESCC, meanwhile it may be an avenue for target therapy. ..
  85. Tang D, Kryvenko O, Mitrache N, Do K, Jankowski M, Chitale D, et al. Methylation of the RARB gene increases prostate cancer risk in black Americans. J Urol. 2013;190:317-24 pubmed publisher
    ..We performed a nested case-control study of gene promoter methylation status for 5 genes (APC, RARB, CCND2, RASSF1 and MGMT) measured in benign biopsy specimens from 511 prostate cancer case-control pairs...
  86. Galli R, Paone A, Fabbri M, Zanesi N, Calore F, Cascione L, et al. Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RAR? and tumor regression. Proc Natl Acad Sci U S A. 2013;110:9812-7 pubmed publisher
    ..targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RAR?)...
  87. Wenz A, Borchers K, Tovar G, Kluger P. Bone matrix production in hydroxyapatite-modified hydrogels suitable for bone bioprinting. Biofabrication. 2017;9:044103 pubmed publisher
    ..polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared...
  88. Sasaki K, Toshiyuki K, Guo B, Ideta K, Hayashi Y, Hirajima T, et al. Calcination effect of borate-bearing hydroxyapatite on the mobility of borate. J Hazard Mater. 2018;344:90-97 pubmed publisher
    ..Co-precipitation of borate with hydroxyapatite (HAp), using Ca(OH)2, is known to be an effectively fast method for stabilization of borate as well as ..
  89. Kim M, Kim B, Park H, Lee J, Park W. Injectable methylcellulose hydrogel containing calcium phosphate nanoparticles for bone regeneration. Int J Biol Macromol. 2018;109:57-64 pubmed publisher
    ..The XRD results indicate that the in situ synthesized CaP NPs had a crystalline phase of hydroxyapatite (HAP). The in vitro study using mesenchymal stem cells showed that MC-HAP NPs composite hydrogel was biocompatible...
  90. Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Mori M, et al. Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res. 2003;63:3724-8 pubmed
    ..We examined the promoter methylation status of von Hippel-Lindau disease (VHL), retinoic acid receptor beta (RAR-beta), RAS association domain family 1A (RASSF1A), and fragile histidine triad (FHIT) genes in 22 ..
  91. Bagadi S, Prasad C, Kaur J, Srivastava A, Prashad R, Gupta S, et al. Clinical significance of promoter hypermethylation of RASSF1A, RARbeta2, BRCA1 and HOXA5 in breast cancers of Indian patients. Life Sci. 2008;82:1288-92 pubmed publisher
    ..In this context the association of HOXA5 methylation with loss of ERalpha (p=0.009) is noteworthy. ..
  92. Swellam M, Abdelmaksoud M, Sayed Mahmoud M, Ramadan A, Abdel Moneem W, Hefny M. Aberrant methylation of APC and RARβ2 genes in breast cancer patients. IUBMB Life. 2015;67:61-8 pubmed publisher
    ..Thus methylated APC and RARβ2 genes might be valuable serum-based molecular markers for early detection of breast cancer. ..