raptor

Summary

Gene Symbol: raptor
Description: regulatory associated protein of MTOR complex 1
Alias: KOG1, Mip1, regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, raptor
Species: human

Top Publications

  1. ncbi mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    Do Hyung Kim
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 110:163-75. 2002
  2. ncbi Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
  3. ncbi The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
  4. ncbi Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
    Kin Man Choi
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Biol Chem 278:19667-73. 2003
  5. ncbi TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    Stefanie S Schalm
    The Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 13:797-806. 2003
  6. ncbi Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    Estela Jacinto
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 6:1122-8. 2004
  7. ncbi Rheb binds and regulates the mTOR kinase
    Xiaomeng Long
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 15:702-13. 2005
  8. ncbi Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
    Dos D Sarbassov
    Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Biol Chem 280:39505-9. 2005
  9. ncbi The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    Stefan M Schieke
    Cardiology Branch, Laboratory of Cardiac Energetics, Flow Cytometry Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:27643-52. 2006
  10. ncbi Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    Emilie Vander Haar
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nat Cell Biol 9:316-23. 2007

Research Grants

  1. Angela N Carter; Fiscal Year: 2014
  2. RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATION TO STRESS
    Leonard Jefferson; Fiscal Year: 2005
  3. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
  4. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
  5. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2011
  6. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010

Scientific Experts

  • L S Jefferson
  • Bruno D Fonseca
  • Mohan R Kaadige
  • Boris Shor
  • Kazuhiro Nakayama
  • Brian J Morris
  • Zheng Fu
  • Leighton R James
  • Charles Lang
  • Laura R Pearce
  • Lifu Wang
  • Joseph Avruch
  • Kenta Hara
  • John Lawrence
  • Kazuyoshi Yonezawa
  • Alexandros Tzatsos
  • David M Sabatini
  • Yasemin Sancak
  • Siraj M Ali
  • Angela N Carter
  • Audrey Carriere
  • Diane C Fingar
  • Do Hyung Kim
  • Noriko Oshiro
  • Timothy R Peterson
  • D D Sarbassov
  • Chang Sun
  • Philippe P Roux
  • Dana M Gwinn
  • Estela Jacinto
  • Juan F Linares
  • Carson C Thoreen
  • Angeles Duran
  • Dos D Sarbassov
  • Hugo A Acosta-Jaquez
  • Jie Lin
  • Takeshi Kaizuka
  • Satoshi Eguchi
  • Shomit Sengupta
  • Sang Hoon Ha
  • Kun Liang Guan
  • Daojing Li
  • David A Guertin
  • Anto P Rajkumar
  • Clare Stretton
  • Scot R Kimball
  • Xin Li
  • Kimberly Coffman
  • Ashish Saxena
  • Ken Inoki
  • Christopher G Proud
  • Maria T Diaz-Meco
  • Sajjad Hussain
  • Jorge Moscat
  • Sonja I Berndt
  • John Blenis
  • Tianyan Gao
  • Yemsrach K Tekletsadik
  • Jung Min Han
  • Demetrios Kalaitzidis
  • Bridgette N Ray
  • Darko Stevanovic
  • Xianghua Yan
  • Chiharu Tokunaga
  • Xuemin Wang
  • Sujuti Hidayat
  • Lloyd P McMahon
  • Ken ichi Yoshino
  • E K Kim
  • Angela M Farrelly
  • Jing Li
  • Alejandro Vazquez-Martin
  • Elaine A Dunlop
  • Iliana Ramírez-Rangel
  • Nirmalya Dey
  • Paul Langlais
  • Jung Ho Back
  • Rui Gong
  • Abid A Kazi
  • Susanna M I Goorden
  • Hitoshi Murata
  • Anne Beugnet
  • Yves Romeo
  • Ali Sharma
  • M Rosner
  • Kathryn G Foster
  • L Lamas
  • Francisco Ramírez-Valle
  • Noboru Mizushima
  • Tohru Natsume

Detail Information

Publications114 found, 100 shown here

  1. ncbi mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    Do Hyung Kim
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 110:163-75. 2002
    ..We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway...
  2. ncbi Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    ..b>Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha...
  3. ncbi The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    Hiroki Nojima
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    J Biol Chem 278:15461-4. 2003
    ..Raptor (regulatory associated protein of mTOR) is a recently identified mTOR binding partner that also binds p70S6k and 4E-BP1 and is essential ..
  4. ncbi Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
    Kin Man Choi
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Biol Chem 278:19667-73. 2003
    ..Wild-type PHAS-I, but none of the mutant proteins, was coimmunoprecipitated with hemagglutinin-tagged raptor, an mTOR-associated protein, after extracts of cells overexpressing raptor had been supplemented with recombinant ..
  5. ncbi TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    Stefanie S Schalm
    The Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 13:797-806. 2003
    ..However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling...
  6. ncbi Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    Estela Jacinto
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 6:1122-8. 2004
    ..mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor. Like yeast TORC2, mTORC2 is rapamycin insensitive and seems to function upstream of Rho GTPases to regulate the ..
  7. ncbi Rheb binds and regulates the mTOR kinase
    Xiaomeng Long
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 15:702-13. 2005
    The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation...
  8. ncbi Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
    Dos D Sarbassov
    Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Biol Chem 280:39505-9. 2005
    The raptor-mTOR protein complex is a key component of a nutrient-sensitive signaling pathway that regulates cell size by controlling the accumulation of cellular mass...
  9. ncbi The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    Stefan M Schieke
    Cardiology Branch, Laboratory of Cardiac Energetics, Flow Cytometry Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:27643-52. 2006
    ..particular, we demonstrate that the level of complex formation between mTOR and one of its known protein partners, raptor, correlated with overall mitochondrial activity...
  10. ncbi Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    Emilie Vander Haar
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nat Cell Biol 9:316-23. 2007
    ..These findings identify PRAS40 as an important regulator of insulin sensitivity of the Akt-mTOR pathway and a potential target for the treatment of cancers, insulin resistance and hamartoma syndromes...
  11. ncbi PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 25:903-15. 2007
    ..We identify PRAS40 as a raptor-interacting protein that binds to mTORC1 in insulin-deprived cells and whose in vitro interaction with mTORC1 is ..
  12. pmc Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
    ..Two complexes of mTOR have been identified: complex 1, consisting of mTOR-Raptor (regulatory associated protein of mTOR)-mLST8 (termed mTORC1), and complex 2, comprising mTOR-Rictor (rapamycininsensitive companion of ..
  13. pmc cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
    Ewan M Smith
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 27:1005-16. 2008
    ..These data closely match the control of Ser359 phosphorylation and indicate that cdc2 may be regulated by mTORC1...
  14. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    ..We report here that AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor...
  15. doi Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
    Audrey Carriere
    Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal Quebec, H3C 3J7, Canada
    Curr Biol 18:1269-77. 2008
    ..The scaffolding protein Raptor binds to mTOR and recruits substrates to the rapamycin-sensitive mTOR complex 1 (mTORC1)...
  16. pmc Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Biochem J 421:29-42. 2009
    ..Our results indicate that Ku-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated...
  17. pmc DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    Timothy R Peterson
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 137:873-86. 2009
    ..Thus, we identify a novel mTOR-interacting protein whose deregulated overexpression in multiple myeloma cells represents a mechanism for activating PI3K/Akt signaling and promoting cell survival...
  18. pmc Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    Yasemin Sancak
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 141:290-303. 2010
    ..Thus, Rag-Ragulator-mediated translocation of mTORC1 to lysosomal membranes is the key event in amino acid signaling to mTORC1...
  19. pmc Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
    Takeshi Kaizuka
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biol Chem 285:20109-16. 2010
    ..These results indicate that Tti1 and Tel2 are important not only for mTOR stability but also for assembly of the mTOR complexes to maintain their activities...
  20. pmc Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 6:e1001178. 2010
    ..The regulatory associated protein of MTOR encoded by the RPTOR gene is a key component of this pathway...
  21. doi Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    Jung Min Han
    Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151 742, Republic of Korea
    Cell 149:410-24. 2012
    ..This work demonstrates that LRS is a key mediator for amino acid signaling to mTORC1...
  22. pmc Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:501-12. 2013
    ..Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups...
  23. ncbi Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    Robbie Loewith
    Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Cell 10:457-68. 2002
    ..We describe two functionally distinct TOR complexes. TOR Complex 1 (TORC1) contains TOR1 or TOR2, KOG1 (YHR186c), and LST8. TORC2 contains TOR2, AVO1 (YOL078w), AVO2 (YMR068w), AVO3 (YER093c), and LST8...
  24. ncbi Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    D D Sarbassov
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Curr Biol 14:1296-302. 2004
    ..mTOR interacts with the raptor and GbetaL proteins to form a complex that is the target of rapamycin...
  25. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation...
  26. ncbi Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    Dos D Sarbassov
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 22:159-68. 2006
    ..rapamycin interacts with and inhibits the kinase activity of a multiprotein complex composed of mTOR, mLST8, and raptor (mTORC1)...
  27. ncbi Localization of Rheb to the endomembrane is critical for its signaling function
    Claudia Buerger
    Division of Signaling Biology, Ontario Cancer Institute, University Health Network, 610 University Ave, Toronto, Ont, Canada M5G 2M9
    Biochem Biophys Res Commun 344:869-80. 2006
    ..Consistent with the notion that the endomembrane may serve as a platform for the assembly of a functional Rheb/mTOR complex, treatment of cells with brefeldin A interferes with transmission of Rheb signals to p70S6K...
  28. ncbi mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    Maria A Frias
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 16:1865-70. 2006
    ..Even though all mTORC2s can phosphorylate Akt/PKB in vitro, insulin regulates the activity of only two of them. Thus, we propose that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals...
  29. ncbi SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    Estela Jacinto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 127:125-37. 2006
    Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) protein complexes...
  30. pmc Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    Qian Yang
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 20:2820-32. 2006
    ..These data demonstrate that Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling...
  31. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
    ..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb...
  32. pmc Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    Andrew Y Choo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17414-9. 2008
    ..This reemerged 4E-BP1 phosphorylation is rapamycin-resistant but still requires mTOR, Raptor, and mTORC1's activity...
  33. pmc Characterization of a novel splicing variant in the RAPTOR gene
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Mutat Res 662:88-92. 2009
    ..Raptor, the regulatory associated protein of mTOR, is an important member in this signaling pathway...
  34. pmc ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
    Audrey Carriere
    Department of Pathology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:567-77. 2011
    ..Here, we show that Raptor, an essential scaffolding protein of the mTOR complex 1 (mTORC1), becomes phosphorylated on proline-directed sites ..
  35. pmc Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
    Rui Gong
    Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Genes Dev 25:1668-73. 2011
    ..GTPases play an essential role in relaying amino acid signals to TORC1 activation through direct interaction with raptor and recruitment of the TORC1 complex to lysosomes...
  36. pmc Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 140:932-8. 2010
    ..of eukaryotic initiation factor (eIF)-4E binding protein-1 (4EBP1), eIF4E-eIF4G binding, and 4EBP1-regulatory associated protein of mTOR (raptor) binding, but not mTOR-raptor binding...
  37. ncbi Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
    David L Williamson
    Dept of Cellular and Molecular Physiology, H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 291:E80-9. 2006
    ..pathway, as indicated by increased association of Hamartin with Tuberin, increased association of regulatory associated protein of mTOR with mTOR, and dephosphorylation of the downstream targets ribosomal protein S6 kinase-1 and ..
  38. pmc Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells
    Zheng Fu
    Digestive Health Center of Excellence, Univ of Virginia Health System, PO Box 800708, Charlottesville, VA 22908, USA
    Am J Physiol Gastrointest Liver Physiol 297:G632-40. 2009
    ..reduced expression of their upstream regulators, the mammalian target of rapamycin (mTOR) and the regulatory associated protein of mTOR (Raptor)...
  39. ncbi P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
    Ivette Hernández-Negrete
    Department of Pharmacology, CINVESTAV IPN, Apartado Postal 14 740, Mexico DF, 07000 Mexico
    J Biol Chem 282:23708-15. 2007
    ..mTORC2 has been described as the catalytic complex that phosphorylates AKT/PKB at Ser-473 and elicits activation of Rho GTPases and cytoskeletal reorganization. Thus, P-Rex1 links mTOR signaling to Rac activation and cell migration...
  40. ncbi HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway
    Peter T Jindra
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine and Molecular Biology Institute, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:2357-66. 2008
    ..interfering RNA technology to abrogate mTOR, rapamycin-insensitive companion of mTOR (rictor), or regulatory associated protein of mTOR (raptor) to study the function of these gene products to activate proteins involved in MHC class I-..
  41. pmc Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    Han C Dan
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Genes Dev 22:1490-500. 2008
    ..The mTOR-associated protein Raptor is required for the ability of Akt to induce NF-kappaB activity...
  42. doi Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities
    Wen Cheng Su
    Graduate Institute of Molecular Medicine, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan
    FEBS Lett 583:2793-8. 2009
    ..We conclude that ribavirin enhances activities of mTOR and p53, which may account for its antiviral and antitumor effects...
  43. ncbi Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)
    Alejandro Vazquez-Martin
    Unit of Translational Research, Catalan Institute of Oncology Girona, Girona Biomedical Research Institute, Girona, Spain
    Cell Cycle 10:3140-52. 2011
    b>Raptor is the key scaffolding protein that recruits mTOR substrates to rapamycin-sensitive mTOR complex 1 (mTORC1), a molecular integrator of mitogenic and nutrient/energy environmental inputs into protein translation and cell growth...
  44. pmc A conserved role of IQGAP1 in regulating TOR complex 1
    Yemsrach K Tekletsadik
    Institute for Biotechnology and Life Sciences, Cornell University, Ithaca, NY 14853 2703, USA
    J Cell Sci 125:2041-52. 2012
    ..These results could have implications for the development of the next generation of anticancer therapeutics...
  45. pmc mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
    Xin Li
    Markey Cancer Center, University of Kentucky, Lexington, KY, USA
    EMBO Rep 15:191-8. 2014
    ..Taken together, our findings identify PKCζ as a novel substrate and downstream effector of mTORC2 signaling. ..
  46. pmc Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis
    Kimberly Coffman
    From the Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California 90095
    J Biol Chem 289:4723-34. 2014
    ..b>Raptor in mTOR complex 1 is believed to recruit 4E-BP1, facilitating phosphorylation of 4E-BP1 by the kinase mTOR...
  47. doi Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder
    Anto P Rajkumar
    Department of Biomedicine, Institute of Human Genetics, Aarhus University, Aarhus, Denmark Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
    Bipolar Disord 17:205-11. 2015
    ....
  48. pmc La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
    Bruno D Fonseca
    From the Children s Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    J Biol Chem 290:15996-6020. 2015
    ..Our data show the following: (i) LARP1 associates with mTORC1 via RAPTOR; (ii) LARP1 interacts with TOP mRNAs in an mTORC1-dependent manner; (iii) LARP1 binds the 5'TOP motif to repress ..
  49. pmc Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
    Juan F Linares
    Cell Death and Survival Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Rep 12:1339-52. 2015
    ..Analysis of human prostate cancer samples showed upregulation of these three components of the pathway, which correlated with enhanced mTORC1 activation. ..
  50. pmc GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
    Clare Stretton
    Division of Cell Signalling and Immunology, James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U K
    Biochem J 470:207-21. 2015
    ..show that GSK3 regulates mTORC1 activity through its ability to phosphorylate the mTOR-associated scaffold protein raptor (regulatory-associated protein of mTOR) on Ser(859)...
  51. ncbi mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type
    Daojing Li
    Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
    FASEB J 30:3388-3399. 2016
    ..For that purpose, we generated mice deficient in the regulatory associated protein of mTOR (Raptor) in microglia, whose mTORC1 signaling was blocked, by crossing Raptor loxed (Raptor..
  52. pmc Hsp70 associates with Rictor and is required for mTORC2 formation and activity
    Jheralyn Martin
    Department of Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, 16111 Plummer Street 151, Building 1, Room C111A, Los Angeles, CA 91343, USA
    Biochem Biophys Res Commun 372:578-83. 2008
    ..These data suggest that Hsp70 is a component of mTORC2 and is required for proper assembly and activity of the kinase both constitutively and following heat shock...
  53. pmc The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
    Makiko Koike-Kumagai
    Neural Morphogenesis Laboratory, National Institute of Genetics, Mishima, Japan
    EMBO J 28:3879-92. 2009
    ..These findings suggest that TORC2 likely acts together with the Trc signalling pathway to regulate the dendritic tiling of class IV da neurons, and thus uncover the first neuronal function of TORC2 in vivo...
  54. pmc A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2
    Hitoshi Murata
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikatacho, Kita ku, Okayama 700 8558, Japan
    J Biol Chem 286:7182-9. 2011
    ..Furthermore, overexpression of PINK1 enhanced cell motility. These results indicate that PINK1 exerts its cytoprotective function not only in mitochondria but also in the cytoplasm through activation of mTORC2...
  55. pmc Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57
    Iliana Ramírez-Rangel
    Departamento de Farmacología CINVESTAV IPN, Av Instituto Politecnico Nacional 2508, Col San Pedro Zacatenco, 07360, Apartado Postal 14 740, 07000 Mexico D F, Mexico
    Mol Cell Biol 31:1657-71. 2011
    ..known as an endoplasmic reticulum (ER) resident, we demonstrate its presence at the cytosol, together with mTOR, Raptor, and Rictor as well as a pool of these proteins associated to the ER...
  56. doi Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
    E K Kim
    MRC for Ischemic Tissue Regeneration and Medical Research Institute, Department of Pharmacology, Pusan National University School of Medicine, Yangsan si, Republic of Korea
    Oncogene 30:2954-63. 2011
    ..However, inactivation of mTORC1 by silencing of Raptor had no effect. Silencing of Akt1 but not Akt2 attenuated IGF-1-induced SKOV-3 cell migration...
  57. pmc Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    Jung Ho Back
    Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:19100-8. 2011
    ..SIRT1 physically interacts with the mTOR-Raptor complex, and a single amino acid substitution in the TOS (TOR signaling) motif in the SIRT1 prevented Ser-47 ..
  58. pmc p62 is a key regulator of nutrient sensing in the mTORC1 pathway
    Angeles Duran
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92307, USA
    Mol Cell 44:134-46. 2011
    ..Here, we identify raptor as an interacting partner of p62...
  59. pmc Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro
    Xianghua Yan
    College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, China
    Autophagy 8:213-21. 2012
    ....
  60. pmc mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
    Demetrios Kalaitzidis
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School and the Harvard Stem Cell Institute, Boston, MA 02115, USA
    Cell Stem Cell 11:429-39. 2012
    ..We deleted the mTORC1 component, regulatory-associated protein of mTOR (Raptor), in mouse HSCs and its loss causes a nonlethal phenotype characterized by pancytopenia, splenomegaly, and the ..
  61. pmc Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor
    Sajjad Hussain
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Mol Cell Biol 33:1188-97. 2013
    ..By assembling with different cofactors, mTOR forms two complexes with distinct biological functions. Raptor-bound mTOR (mTORC1) governs cap-dependent mRNA translation, whereas mTOR, rictor, and mSin1 (mTORC2) activate the ..
  62. pmc Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression
    Ashish Saxena
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States
    Eur J Cancer 49:3311-9. 2013
    ..fidarestat, prevented the EGF-induced phosphorylation of mammalian target of rapamycin (mTOR), regulatory associated protein of mTOR (Raptor), eukaryotic initiation factor 4E (eIF4E), p70 S6 kinase (S6K) and eukaryotic initiation ..
  63. pmc Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    Heather L Wieman
    Department of Pharmacology and Cancer Biology, and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 18:1437-46. 2007
    ..may regulate Glut1, we analyzed the role of Akt activation of mammalian target of rapamycin (mTOR)/regulatory associated protein of mTOR (RAPTOR) and inhibition of glycogen synthase kinase (GSK)3...
  64. doi Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake
    Darko Stevanovic
    Institute of Medical Physiology, University of Belgrade, Belgrade, Serbia
    Neuroendocrinology 96:24-31. 2012
    ..The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin...
  65. pmc Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics
    Bridgette N Ray
    Departments of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Endocrinol 26:1056-73. 2012
    ..novel GH-dependent sites tested [regulatory sites in proline-rich Akt substrate, 40 kDA (PRAS40), regulatory associated protein of mTOR, ATP-citrate lyase, Na(+)/H(+) exchanger-1, N-myc downstream regulated gene 1, and Shc])...
  66. ncbi Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
    Anne Beugnet
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 278:40717-22. 2003
    ..Other recent work has shown that the protein raptor binds to mTOR and 4E-BP1...
  67. ncbi A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 35:349-56. 2003
    ..The distal peak of association is in RAPTOR (p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats)...
  68. ncbi Raptor, a binding partner of target of rapamycin
    Kazuyoshi Yonezawa
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Biochem Biophys Res Commun 313:437-41. 2004
    ..Raptor (regulatory associated protein of mTOR) is a 150 kDa mTOR binding protein that is essential for TOR signaling in vivo and also binds ..
  69. ncbi Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex
    Lloyd P McMahon
    Department of Pharmacology, P O Box 800735, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 19:175-83. 2005
    The mammalian target of rapamycin (mTOR) functions with raptor and mLST8 in a signaling complex that controls rates of cell growth and proliferation...
  70. pmc Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
    Xuemin Wang
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 25:2558-72. 2005
    ..Although 4E-BP1 and S6K1 bind the mTOR partner, raptor, our data indicate that the outputs from mTOR to 4E-BP1 and S6K1 are distinct...
  71. ncbi Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
    Siraj M Ali
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, 02142, USA
    J Biol Chem 280:19445-8. 2005
    ..Here, we demonstrate that the raptor-mTOR complex phosphorylates the rapamycin-sensitive forms of S6K1, while the distinct rictor-mTOR complex ..
  72. ncbi Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
    Scot R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Nutr 136:227S-31S. 2006
    ..targets is controlled in part through its interaction with the regulatory-associated protein of mTOR (known as raptor) and the G protein beta-subunit-like protein...
  73. ncbi Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:24293-303. 2006
    ..and mediated by mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a signaling complex containing mTOR, raptor, and mLST8...
  74. ncbi Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size
    Satoshi Eguchi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Genes Cells 11:757-66. 2006
    ..4E-BP1 has been shown to associate with the scaffold protein raptor through its TOS and RAIP motifs to be recognized by mTOR...
  75. ncbi PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals
    Sang Hoon Ha
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbook 790 784, Republic of Korea
    Cell Signal 18:2283-91. 2006
    ..This abrogation was found to be the result of complex formation between PLD2 and mTOR/raptor. PLD2 possesses a TOS-like motif (Phe-Glu-Val-Gln-Val, a.a...
  76. ncbi Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
    A Iwamaru
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:1840-51. 2007
    ..because these agents rather than acting as mTOR kinase inhibitors instead interfere with the function of only mTOR/raptor (regulatory-associated protein of mTOR) complex and thus do not perturb all mTOR functions...
  77. ncbi Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
    Stephen C Land
    Institute of Medical Genetics, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, Wales, United Kingdom
    J Biol Chem 282:20534-43. 2007
    ..We show that regulatory associated protein of mTOR (Raptor) interacts with HIF1alpha and requires an mTOR signaling (TOS) motif located in the N ..
  78. ncbi PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:20036-44. 2007
    ..In response to insulin and nutrients, mTORC1, consisting of mTOR, raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates eukaryotic initiation factor ..
  79. ncbi Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation
    Yinong Wang
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circ Res 101:560-9. 2007
    ..Signaling by the mammalian target of rapamycin raptor complex, known as mTORC1, is associated with cell growth and is active within arteriosclerotic lesions but is not ..
  80. pmc The selectivity of protein kinase inhibitors: a further update
    Jenny Bain
    Division of Signal Transduction Therapy, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 408:297-315. 2007
    ..protein kinase B/Akt), rapamycin to inhibit TORC1 [mTOR (mammalian target of rapamycin)-raptor (regulatory associated protein of mTOR) complex], CT 99021 to inhibit GSK3 (glycogen synthase kinase 3), BI-D1870 and SL0101 or FMK (..
  81. pmc Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival
    Y Wang
    School of Medicine, University of California Davis, Sacramento, CA, USA
    Oncogene 27:7106-17. 2008
    ..The net effect of rapamycin is determined by its individual effects on the mTOR complexes mTORC1 (mTOR/raptor/GbetaL) and mTORC2 (mTOR/rictor/sin1/GbetaL)...
  82. doi Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
    Joseph Avruch
    Diabetes Research Laboratory, Department of Molecular Biology, Diabetes Unit, Medical Services, Massachusetts General Hospital, Simches Research Building, 6408, 185 Cambridge Street, Boston, MA 02114, USA
    Biochem Soc Trans 37:223-6. 2009
    ..activated, the mTOR catalytic domain phosphorylates substrates only when they are bound to raptor (regulatory associated protein of mTOR), a separate polypeptide within the complex...
  83. doi mTOR phosphorylated at S2448 binds to raptor and rictor
    M Rosner
    Medical Genetics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Amino Acids 38:223-8. 2010
    In mammalian cells, the mammalian target of rapamycin (mTOR) forms an enzyme complex with raptor (together with other proteins) named mTOR complex 1 (mTORC1), of which a major target is the p70 ribosomal protein S6 kinase (p70S6K)...
  84. pmc Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    Nao Hosokawa
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Mol Biol Cell 20:1981-91. 2009
    ..ULK1 is dephosphorylated by rapamycin treatment or starvation. These data suggest that mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1-Atg13-FIP200 complex...
  85. doi Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
    Anne Ulrike Trendelenburg
    Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, Basel, Switzerland
    Am J Physiol Cell Physiol 296:C1258-70. 2009
    ..Blockade of the Akt/mTOR pathway, using small interfering RNA to regulatory-associated protein of mTOR (RAPTOR), a component of TOR signaling complex 1 (TORC1), increases myostatin-induced phosphorylation of Smad2, ..
  86. doi Expression of genes related to muscle plasticity after strength and power training regimens
    L Lamas
    School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, SP, Brazil
    Scand J Med Sci Sports 20:216-25. 2010
    ..hypertrophy and phenotype shift, mammalian target of rapamycin (mTOR), regulatory-associated protein of mTOR (RAPTOR), rapamycin-insensitive companion of m-TOR (RICTOR), calcineurin and calcipressin gene expression]...
  87. pmc Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR
    Alexandros Tzatsos
    Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    J Biol Chem 284:22525-34. 2009
    ..Here, it has been shown that knockdown of mTOR, Raptor, and mLST8, but not Rictor and mSin1, suppresses insulin-stimulated phosphorylation of IRS-1 at Ser-636/639 and ..
  88. ncbi Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility
    Nicholas Gulati
    Department of Neurosurgery, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 35:731-40. 2009
    ..Expression of pAKT was suppressed by siRNA silencing of mTORC2 co-protein rictor, but not by mTORC1 co-protein raptor. GBM cell proliferation and motility paralleled the activation of mTORC2...
  89. pmc Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
    Kathryn G Foster
    Department of Cell and Developmental Biology, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 285:80-94. 2010
    ..To elucidate the poorly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interacting partner...
  90. pmc Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk
    Meng Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:2047-52. 2009
    ..In individual SNP analysis, four SNPs in regulatory associated protein of mTOR (RAPTOR) remained significant after correcting for multiple testing: rs11653499 [odds ratio (OR): ..
  91. pmc Influence of glucosamine on glomerular mesangial cell turnover: implications for hyperglycemia and hexosamine pathway flux
    Leighton R James
    Dept of Medicine, Nephrology Division, Univ of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
    Am J Physiol Endocrinol Metab 298:E210-21. 2010
    ..The proliferative response to high glucose and hexosamine flux is rapamycin-sensitive, suggesting that this effect is associated with signaling through rapamycin-sensitive mTOR complex 1 (mTORC1)...
  92. pmc Dysregulation of mTOR signaling in fragile X syndrome
    Ali Sharma
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Neurosci 30:694-702. 2010
    ..of juvenile Fmr1 knock-out mice by four functional readouts: (1) association of mTOR with regulatory associated protein of mTOR; (2) mTOR kinase activity; (3) phosphorylation of mTOR downstream targets S6 kinase and 4E-binding ..
  93. pmc Raptor is phosphorylated by cdc2 during mitosis
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, La Jolla, California, United States of America
    PLoS ONE 5:e9197. 2010
    ..AMPK directly phosphorylates the critical mTOR binding partner raptor inhibiting mTORC1 (mTOR-raptor rapamycin sensitive mTOR kinase complex 1)...
  94. pmc Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:505-17. 2010
    ....
  95. pmc Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation
    Francisco Ramírez-Valle
    Department of Microbiology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 30:3151-64. 2010
    ..We describe previously unknown G(2)/M-specific phosphorylation of a component of mTORC1, the protein raptor, and demonstrate that mitotic raptor phosphorylation alters mTORC1 function during mitosis...
  96. pmc Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis
    Abid A Kazi
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Shock 35:117-25. 2011
    ..PRAS40 (proline-rich Akt substrate 40) and reciprocally increased S792-phosphorylated raptor (regulatory associated protein of mTOR). Despite these phosphorylation changes, sepsis did not alter PRAS40 binding to raptor...
  97. doi mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    Shomit Sengupta
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 468:1100-4. 2010
    ..The loss of raptor (regulatory associated protein of mTOR, complex 1) an essential mTORC1 component, has the opposite effects...
  98. pmc Rheb is essential for murine development
    Susanna M I Goorden
    Department of Neuroscience, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Mol Cell Biol 31:1672-8. 2011
    ..In contrast to mTOR or regulatory-associated protein of mTOR (Raptor) mutants, the inner cell mass of Rheb(-/-) embryos differentiated normally...
  99. pmc The identification of raptor as a substrate for p44/42 MAPK
    Paul Langlais
    Center for Metabolic and Vascular Biology, Arizona State University, P O Box 874501, Tempe, Arizona 85287 4501, USA
    Endocrinology 152:1264-73. 2011
    The adaptor protein raptor is the functional identifier for mammalian target of rapamycin (mTOR) complex 1 (mTORC1), acting to target mTOR to specific substrates for phosphorylation and regulation...
  100. doi Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 436:169-79. 2011
    ..Two complexes of mTOR have been identified: complex 1 (mTORC1), consisting of mTOR, Raptor (regulatory associated protein of mTOR) and mLST8 (mammalian lethal with SEC13 protein 8) and complex 2 (mTORC2) consisting of mTOR, ..

Research Grants6

  1. Angela N Carter; Fiscal Year: 2014
    ..These processes are regulated via mTOR interactions with the Raptor (regulatory associated protein of mTOR) protein, which leads to activation of mTOR complex 1 (mTORC1)...
  2. RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATION TO STRESS
    Leonard Jefferson; Fiscal Year: 2005
    ..abstract_text> ..
  3. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  4. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  5. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2011
    ..The interaction of TORC1 with its known substrates through raptor has been elucidated...
  6. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..