Gene Symbol: RAP55
Description: LSM14A, mRNA processing body assembly factor
Alias: C19orf13, FAM61A, RAP55, RAP55A, protein LSM14 homolog A, LSM14 homolog A, LSM14A, SCD6 homolog A, RNA-associated protein 55, RNA-associated protein 55A, alphaSNBP, family with sequence similarity 61, member A, hRAP55, hRAP55A, protein SCD6 homolog
Species: human
Products:     RAP55

Top Publications

  1. Yang W, Yu J, Gulick T, Bloch K, Bloch D. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA. 2006;12:547-54 pubmed
    ..Serum from one of these patients was used to identify a cDNA encoding RAP55, a 463-amino acid protein. RAP55 colocalized with previously identified P-body components DCP1a and Ge-1...
  2. Swetloff A, Conne B, Huarte J, Pitetti J, Nef S, Vassalli J. Dcp1-bodies in mouse oocytes. Mol Biol Cell. 2009;20:4951-61 pubmed publisher
    ..foci in mouse oocytes, as revealed by the presence of Dcp1a and the colocalization of RNA-associated protein 55 (RAP55) and the DEAD box RNA helicase Rck/p54, two proteins associated with P-bodies and translational control...
  3. Li Z, Chen R, Zhao J, Qi Z, Ji L, Zhen Y, et al. LSM14A inhibits porcine reproductive and respiratory syndrome virus (PRRSV) replication by activating IFN-β signaling pathway in Marc-145. Mol Cell Biochem. 2015;399:247-56 pubmed publisher
    ..Furthermore, the down-regulation of LSM14A by PRRSV might represent an important mechanism by which PRRSV invades the host. Our study sheds light on the possibility of developing a new strategy to control this disease. ..
  4. Ayache J, Bénard M, Ernoult Lange M, Minshall N, Standart N, Kress M, et al. P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes. Mol Biol Cell. 2015;26:2579-95 pubmed publisher
    ..Three proteins were required in all tested conditions: DDX6, 4E-T, and LSM14A. These results reveal the variety of pathways of P-body assembly, which all nevertheless share three key factors connecting P-body assembly to repression. ..
  5. Hua K, Li H, Chen H, Foda M, Luo R, Jin H. Functional characterization of duck LSm14A in IFN-β induction. Dev Comp Immunol. 2017;76:255-261 pubmed publisher
    ..The present study results indicate that the duLSm14A is an essential sensor that mediates duck innate immunity against viral infections. ..
  6. Seto E, Onizuka Y, Nakajima Shimada J. Host cytoplasmic processing bodies assembled by Trypanosoma cruzi during infection exert anti-parasitic activity. Parasitol Int. 2015;64:540-6 pubmed publisher
    ..Our results suggest that the accumulated PBs partially contribute to anti-parasitic responses by manipulating the host's mRNA metabolism. ..
  7. Brandmann T, Fakim H, Padamsi Z, Youn J, Gingras A, Fabian M, et al. Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes. EMBO J. 2018;37: pubmed publisher
    The LSM domain-containing protein LSM14/Rap55 plays a role in mRNA decapping, translational repression, and RNA granule (P-body) assembly...
  8. He Q, Ge W. The tandem Agenet domain of fragile X mental retardation protein interacts with FUS. Sci Rep. 2017;7:962 pubmed publisher
    ..This study may provide a novel insight into FMRP involvement in the intracellular localization of FUS and pathology of FUS-related amyotrophic lateral sclerosis. ..
  9. Lien P, Izumikawa K, Muroi K, Irie K, Suda Y, Irie K. Analysis of the Physiological Activities of Scd6 through Its Interaction with Hmt1. PLoS ONE. 2016;11:e0164773 pubmed publisher
    Scd6, a yeast homologue of human RAP55, is a component of messenger ribonucleoproteins (mRNPs) that repress translation by binding to translation initiation factors, and also is a decapping activator along with the binding partners Edc3 ..

More Information


  1. Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult Lange M, et al. The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res. 2016;44:6318-34 pubmed publisher
    ..Altogether these findings considerably extend our understanding of the role of 4E-T in gene regulation, important in development and neurogenesis. ..
  2. Liu T, Yang Q, Li M, Zhong B, Ran Y, Liu L, et al. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. J Immunol. 2016;196:5101-11 pubmed publisher
    ..Our findings reveal a nuclear mRNA precursor processing and cell-specific regulatory mechanism of antiviral immune responses. ..
  3. Ladomery M, Sommerville J. The Scd6/Lsm14 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes. Biochim Biophys Acta. 2015;1849:1363-73 pubmed publisher
    ..Scd6/Lsm14 proteins, typified by RAP55, function in a wide range of eukaryotes in repressing translation and relocating mRNPs to processing bodies and ..
  4. Marnef A, Sommerville J, Ladomery M. RAP55: insights into an evolutionarily conserved protein family. Int J Biochem Cell Biol. 2009;41:977-81 pubmed publisher
    The RAP55 protein family is evolutionarily conserved in eukaryotes. Two highly conserved paralogues, RAP55A and RAP55B, exist in vertebrates; their functional properties and expression patterns remain to be compared...
  5. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, et al. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109:11770-5 pubmed publisher
    ..These findings suggest that LSm14A is a sensor for both viral RNA and DNA and plays an important role in initiating IFN-? induction in the early phase of viral infection. ..
  6. Wang F, Yu S, Zuo L, Cao C, Hu Y, Chen Z, et al. Excessive Iron and ?-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease. J Geriatr Psychiatry Neurol. 2016;29:187-94 pubmed publisher
    ..Pure apathy reduced quality of life for patients without worsening motor function. Excessive iron and ?-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. ..
  7. Matsumoto K, Nakayama H, Yoshimura M, Masuda A, Dohmae N, Matsumoto S, et al. PRMT1 is required for RAP55 to localize to processing bodies. RNA Biol. 2012;9:610-23 pubmed publisher
    ..b>RAP55A, which is an RNA binding component of mRNPs, acts as a translational repressor and localizes to P-bodies and SGs...
  8. Mok B, Song W, Wang P, Tai H, Chen Y, Zheng M, et al. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. J Virol. 2012;86:12695-707 pubmed publisher
    ..Proteomic screening for cellular proteins which interact with NS1 identified the cellular protein RAP55, which is one of the components of cellular processing bodies (P-bodies) and stress granules...
  9. Mili D, Georgesse D, Kenani A. Localization and role of RAP55/LSM14 in HeLa cells: a new finding on the mitotic spindle assembly. Acta Biochim Pol. 2015;62:613-9 pubmed publisher
    ..This article focuses on the relevant aspects of RAP55/LSM14 position with emphasis on its role in mitotic spindle formation and stability...
  10. Blower M, Nachury M, Heald R, Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005;121:223-34 pubmed
    ..Furthermore, we provide evidence that RNA associates with the mitotic spindle and that it plays a direct, translation-independent role in spindle assembly. Our studies reveal an unexpected function for RNA in spindle morphogenesis. ..
  11. Yoshino H, Hirano M, Stoessl A, Imamichi Y, Ikeda A, Li Y, et al. Homozygous alpha-synuclein p.A53V in familial Parkinson's disease. Neurobiol Aging. 2017;57:248.e7-248.e12 pubmed publisher
    ..Hence, alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications. ..
  12. Albrecht M, Lengauer T. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. 2004;569:18-26 pubmed
    ..Further computational analyses revealed that some methyltransferases contain putative RNA-binding helix-turn-helix domains and zinc fingers. ..
  13. Tanaka K, Ogawa K, Takagi M, Imamoto N, Matsumoto K, Tsujimoto M. RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. J Biol Chem. 2006;281:40096-106 pubmed
    ..Here we identified Xenopus RAP55 (xRAP55) as a component of RNPs that associate with FRGY2, the principal component of maternal mRNPs...