Gene Symbol: RANTES
Description: C-C motif chemokine ligand 5
Alias: D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine 5, T-cell specific protein p288, beta-chemokine RANTES, chemokine (C-C motif) ligand 5, eosinophil chemotactic cytokine, regulated upon activation, normally T-expressed, and presumably secreted, small inducible cytokine subfamily A (Cys-Cys), member 5
Species: human
Products:     RANTES

Top Publications

  1. Herder C, Peeters W, Illig T, Baumert J, de Kleijn D, Moll F, et al. RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. PLoS ONE. 2011;6:e25734 pubmed publisher
    The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans...
  2. Bonecchi R, Locati M, Galliera E, Vulcano M, Sironi M, Fra A, et al. Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor. J Immunol. 2004;172:4972-6 pubmed
    ..By recognizing intact CCL22, but not its truncated variants, D6 expressed on lymphatic endothelial cells may regulate the traffic of CCR4-expressing cells, such as dendritic cells. ..
  3. Skurk T, Mack I, Kempf K, Kolb H, Hauner H, Herder C. Expression and secretion of RANTES (CCL5) in human adipocytes in response to immunological stimuli and hypoxia. Horm Metab Res. 2009;41:183-9 pubmed publisher
    ..The chemokine RANTES (regulated upon activation normal T cell expressed and secreted)/CCL5 is a chemoattractant for various leukocyte ..
  4. Kroeze K, Jurgens W, Doulabi B, van Milligen F, Scheper R, Gibbs S. Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES. J Invest Dermatol. 2009;129:1569-81 pubmed publisher
    ..Several ligands for these receptors, with CCL5/RANTES being the most potent, can induce migration of ASC and DSC in an in vitro wound-healing assay...
  5. Vogiatzi K, Voudris V, Apostolakis S, Kochiadakis G, Thomopoulou S, Zaravinos A, et al. Genetic diversity of RANTES gene promoter and susceptibility to coronary artery disease and restenosis after percutaneous coronary intervention. Thromb Res. 2009;124:84-9 pubmed publisher
    Regulated on activation, normal T cell expressed and secreted (RANTES) gene promoter is a regulatory region and a site of notable genetic diversity...
  6. Gade Andavolu R, Comings D, MacMurray J, Vuthoori R, Tourtellotte W, Nagra R, et al. RANTES: a genetic risk marker for multiple sclerosis. Mult Scler. 2004;10:536-9 pubmed
    Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a beta-chemokine and has been detected in brain lesions of multiple sclerosis (MS) patients...
  7. Cooke G, Tosh K, Ramaley P, Kaleebu P, Zhuang J, Nakiyingi J, et al. A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease. J Infect Dis. 2006;194:666-9 pubmed
    We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1...
  8. Katz D, John Stewart G, Richardson B, Majiwa M, Mabuka J, Lohman Payne B, et al. CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission. Int J Immunogenet. 2010;37:301-5 pubmed publisher
    ..we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, 59356T/C, 59402G/A), RANTES (-403G/A) and SDF-1 (3'801G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads;..
  9. Reale M, Iarlori C, Thomas A, Gambi D, Perfetti B, Di Nicola M, et al. Peripheral cytokines profile in Parkinson's disease. Brain Behav Immun. 2009;23:55-63 pubmed publisher
    ..Basal and LPS-induced levels of MCP-1, RANTES, MIP-1alpha, IL-8, IFNgamma, IL-1beta and TNFalpha were significantly higher in PD patients than in HC subjects (p&..

More Information


  1. Cambien B, Richard Fiardo P, Karimdjee B, Martini V, Ferrua B, Pitard B, et al. CCL5 neutralization restricts cancer growth and potentiates the targeting of PDGFR? in colorectal carcinoma. PLoS ONE. 2011;6:e28842 pubmed publisher
    ..Collectively, our data demonstrate the involvement of CCL5 in the pathogenesis of colorectal carcinoma and point to its potential value as a therapeutic target. ..
  2. Al Abdulhadi S, Helms P, Main M, Smith O, Christie G. Preferential transmission and association of the -403 G --> A promoter RANTES polymorphism with atopic asthma. Genes Immun. 2005;6:24-30 pubmed
    Asthma is a complex inherited disease. The study was undertaken to identify the association of RANTES promoter polymorphisms with atopy and asthma using family-based association tests (FBATs) and generation-specific case-control analyses...
  3. Mishra G, Poojary S, Raj P, Tiwari P. Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of North Central India: an association study with pulmonary tuberculosis. Infect Genet Evol. 2012;12:1120-7 pubmed publisher
    The association of genetic variants of chemokines, CCL2 [MCP-1 (monocyte chemoattractant protein-1)], CCL5 [RANTES (regulated on activation, normal T-cell expressed and secreted)] and their receptors CCR2 and CCR5, respectively, earlier ..
  4. Böger C, Fischereder M, Deinzer M, Aslanidis C, Schmitz G, Stubanus M, et al. RANTES gene polymorphisms predict all-cause and cardiac mortality in type 2 diabetes mellitus hemodialysis patients. Atherosclerosis. 2005;183:121-9 pubmed
    ..The CX3CR1 T280M, and MCP-1 -2518 and RANTES -403 and -28 promoter and intronic In1.1T/C polymorphisms were assessed by real-time PCR...
  5. Madani R, Karastergiou K, Ogston N, Miheisi N, Bhome R, Haloob N, et al. RANTES release by human adipose tissue in vivo and evidence for depot-specific differences. Am J Physiol Endocrinol Metab. 2009;296:E1262-8 pubmed publisher
    ..This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and ..
  6. Murk W, Walsh K, Hsu L, Zhao L, Bracken M, Dewan A. Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum Hered. 2011;71:97-105 pubmed publisher
    ..Lack of evidence of highly reported polymorphisms in the present study highlights the genetic heterogeneity of asthma and emphasizes the need for robust replication of candidate genes. ..
  7. Wang L, Li Y, Chen J, Cui T, Wu J. [Polymorphism of regulated upon activation, normal T cell expressed and secreted promoter region -28 position in Chinese allergic asthmatic children]. Zhonghua Jie He He Hu Xi Za Zhi. 2004;27:394-7 pubmed
    To study the effect of regulated upon activation, normal T cell expressed and secreted (RANTES)-28 polymorphism on allergic asthma in Chinese children...
  8. Selvaraj P, Alagarasu K, Singh B, Afsal K. CCL5 (RANTES) gene polymorphisms in pulmonary tuberculosis patients of south India. Int J Immunogenet. 2011;38:397-402 pubmed publisher
  9. Cho M, Min S, Chang S, Kim K, Heo S, Lee S, et al. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol Lett. 2006;105:159-66 pubmed
    ..In this study, we investigated the ability of TGF-beta1 to regulate RANTES production by activated rheumatoid synovial fibroblasts...
  10. Ben Selma W, Harizi H, Bougmiza I, Ben Kahla I, Letaief M, Boukadida J. Polymorphisms in the RANTES gene increase susceptibility to active tuberculosis in Tunisia. DNA Cell Biol. 2011;30:789-800 pubmed publisher
    b>RANTES plays a pivotal role in attracting and activating various leukocyte populations that control Mycobacterium tuberculosis infection...
  11. Huang C, Fong Y, Lee C, Chen M, Tsai H, Hsu H, et al. CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways. Biochem Pharmacol. 2009;77:794-803 pubmed publisher
    CCL5 (previously called RANTES) is in the CC-chemokine family and plays a crucial role in the migration and metastasis of human cancer cells. Besides, integrins are the major adhesive molecules in mammalian cells...
  12. Duell E, Casella D, Burk R, Kelsey K, Holly E. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:726-31 pubmed
    ..factor-alpha (TNF-A -308G/A), regulated upon activation, normally T cell-expressed, and presumably secreted (RANTES -403G/A), and CC chemokine receptor 5 (CCR5-Delta32) polymorphisms...
  13. Borczuk A, Papanikolaou N, Toonkel R, Sole M, Gorenstein L, Ginsburg M, et al. Lung adenocarcinoma invasion in TGFbetaRII-deficient cells is mediated by CCL5/RANTES. Oncogene. 2008;27:557-64 pubmed
    ..We used a tumor cell invasion system to identify the chemokine CCL5 (RANTES, regulated on activation, normal T-cell expressed and presumably secreted) as a potential downstream mediator of ..
  14. Ye D, Yang S, Li X, Hu Y, Yin J, Zhang G, et al. Polymorphisms in the promoter region of RANTES in Han Chinese and their relationship with systemic lupus erythematosus. Arch Dermatol Res. 2005;297:108-13 pubmed
    ..b>RANTES (regulated on activation, normal T cell expressed and secreted, 17q11...
  15. Rentzos M, Nikolaou C, Andreadou E, Paraskevas G, Rombos A, Zoga M, et al. Circulating interleukin-15 and RANTES chemokine in Parkinson's disease. Acta Neurol Scand. 2007;116:374-9 pubmed
    ..b>RANTES is a C-C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes...
  16. Jang D, Choi B, Kim S. The effects of RANTES/CCR5 promoter polymorphisms on HIV disease progression in HIV-infected Koreans. Int J Immunogenet. 2008;35:101-5 pubmed publisher
    Recent studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, -403G/A and -28C/G, are associated with a slower rate of decline in CD4(+) T-cell number, whereas genetic polymorphisms ..
  17. Fang Q, Wang F, Zhao D. Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk--a meta-analysis. Int J Med Sci. 2010;7:55-61 pubmed
    Regulated upon activation, normal T-cell expressed and secreted (RANTES) is one of the most extensively studied C-C chemokines in allergic inflammation...
  18. Muro M, Marin L, Torio A, Pagan J, Alvarez López M. CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population. Int J Immunogenet. 2008;35:19-23 pubmed publisher
    CCL5/RANTES, a member of the C-C chemokine family, is a potent eosinophil, monocyte, basophile and lymphocyte chemo-attractant at the site of inflammation...
  19. Zhang Y, Huang J, Zhang J, Li X, He C, Xiao Y, et al. RANTES gene polymorphisms and asthma risk: A meta-analysis. Arch Med Res. 2010;41:50-8 pubmed publisher
    b>RANTES is a chemokine that assists the recruitment of inflammatory cells including eosinophils...
  20. Duan Z, Zhao X, Huang D, He L, Chen Y, Zhao C, et al. RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection. Chin Med J (Engl). 2005;118:909-14 pubmed
    Regulated on activation, normal T-cell expressed and secreted (RANTES) plays a critical role in T-lymphocyte activation and proliferation. The process is involved in both acute and chronic phases of inflammation...
  21. Mause S, von Hundelshausen P, Zernecke A, Koenen R, Weber C. Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol. 2005;25:1512-8 pubmed
    Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)...
  22. Leung T, Tang N, Lam C, Li A, Fung S, Chan I, et al. RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children. Respir Med. 2005;99:216-9 pubmed
    G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children...
  23. Sánchez Castañón M, Baquero I, Sanchez Velasco P, Farinas M, Ausín F, Leyva Cobian F, et al. Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain. Int J Tuberc Lung Dis. 2009;13:480-5 pubmed
    ..By contrast, the -403A and -28G alleles, the G-G or A-C haplotypes and the G/G-G/G and A/A-C/C diplotypes may confer susceptibility to PTB. ..
  24. Saad El Din Bessa S, Abo El Magd G, Mabrouk M. Serum chemokines RANTES and monocyte chemoattractant protein-1 in Egyptian patients with atopic asthma: relationship to disease severity. Arch Med Res. 2012;43:36-41 pubmed publisher
    ..The chemokine RANTES (regulated upon activation, normal T -cell expressed and secreted) is an important element for the chemotaxis at ..
  25. Berg K, Madsen H, Garred P, Wiseth R, Gunnes S, Videm V. The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease. Scand J Immunol. 2009;69:36-42 pubmed publisher
    ..Furthermore, the additive contribution from different inflammatory genetic markers strongly enhances the individual severity of cardiovascular disease. ..
  26. Wang S, Wu H, Liu S, Wang P, Ou W, Chou W, et al. CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. PLoS ONE. 2012;7:e35101 pubmed publisher
    Osteosarcoma is characterized by a high malignant and metastatic potential. CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human ..
  27. Pinilla S, Alt E, Abdul Khalek F, Jotzu C, Muehlberg F, Beckmann C, et al. Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion. Cancer Lett. 2009;284:80-5 pubmed publisher
    ..We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells. ..
  28. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, et al. Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol. 2004;122:1175-9 pubmed
    ..growth factor-inducible 14 (Fn14), and produced regulated on activation, normal T expressed and secreted (RANTES) upon TWEAK stimulation in a concentration-dependent manner...
  29. Shah A, Singh D, Buch S, Kumar A. HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-?B pathway. Biochem Biophys Res Commun. 2011;414:112-7 pubmed publisher
    ..6 ± 4.2% at the level of mRNA and 51.8 ± 5.0% at the protein level. This was further confirmed by knocking down NF-?B through the use of siRNA. ..
  30. Vaday G, Peehl D, Kadam P, Lawrence D. Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate. 2006;66:124-34 pubmed
    Expression of the inflammatory chemokine CCL5 (RANTES) by tumor cells is thought to correlate with the progression of several cancers. CCL5 was shown to induce breast cancer cell migration, mediated by the receptor CCR5...
  31. Duma L, Haussinger D, Rogowski M, Lusso P, Grzesiek S. Recognition of RANTES by extracellular parts of the CCR5 receptor. J Mol Biol. 2007;365:1063-75 pubmed
    The chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted) is a natural ligand of CCR5, one of the major HIV-1 coreceptors...
  32. Lee Y, Su C, Chow N, Lai W, Lei H, Chang C, et al. Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res. 2007;126:216-25 pubmed
    ..DEN-2 infection significantly increased the expression levels of IL-6 and RANTES in four of the six lung cancer cell lines, which is consistent with the high expression levels of these molecules ..
  33. Nookala A, Shah A, Noel R, Kumar A. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-?B, AP-1, C/EBP? and C/EBP? transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways. PLoS ONE. 2013;8:e78855 pubmed publisher
    ..This was further confirmed at transcriptional level that AP-1, C/EBP? and C/EBP? were involved in CCL5 up-regulation. ..
  34. Ahlenstiel G, Iwan A, Nattermann J, Bueren K, Rockstroh J, Brackmann H, et al. Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study. World J Gastroenterol. 2005;11:7631-8 pubmed
    Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection...
  35. Sanchez E, Sabio J, Callejas J, de Ramon E, Garcia Portales R, Garcia Hernandez F, et al. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. BMC Med Genet. 2006;7:48 pubmed
    ..The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus...
  36. de Nadai P, Chenivesse C, Gilet J, Porte H, Vorng H, Chang Y, et al. CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo. J Invest Dermatol. 2006;126:2057-64 pubmed
  37. Berres M, Koenen R, Rueland A, Zaldivar M, Heinrichs D, Sahin H, et al. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest. 2010;120:4129-40 pubmed publisher
    ..Herein, we identify the chemokine CCL5 (also known as RANTES), which is induced in murine and human liver after injury, as a central mediator of this interaction...
  38. Jang Y, Chae J, Hyun Y, Koh S, Kim J, Ko M, et al. The RANTES -403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease. Clin Sci (Lond). 2007;113:349-56 pubmed
    In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C>G and -403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary ..
  39. Chu S, Tam C, Wong H, Kam K, Lau Y, Chiang A. Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese. Genes Immun. 2007;8:475-9 pubmed
    ..the association between genetic polymorphisms of three chemokines, monocyte chemoattractant protein-1 (MCP-1), RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1alpha (MIP-..
  40. Soria G, Yaal Hahoshen N, Azenshtein E, Shina S, Leider Trejo L, Ryvo L, et al. Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions. Cytokine. 2008;44:191-200 pubmed publisher
    The chemokines RANTES (CCL5) and MCP-1 (CCL2) were suggested to contribute, independently, to breast malignancy...
  41. El Hage N, Gurwell J, Singh I, Knapp P, Nath A, Hauser K. Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat. Glia. 2005;50:91-106 pubmed
    ..monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6)...
  42. Soria G, Ben Baruch A. The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett. 2008;267:271-85 pubmed publisher
    ..these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast malignancy...
  43. Simeoni E, Winkelmann B, Hoffmann M, Fleury S, Ruiz J, Kappenberger L, et al. Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis. Eur Heart J. 2004;25:1438-46 pubmed
    Polymorphisms in the RANTES (G-403A), monocyte chemoattractant protein-1 (MCP-1; A-2518G), stromal cell-derived factor-1beta (SDF-1beta; G801A), and C-C chemokine receptor-5 (CCR5; Delta32) genes have been associated with functional ..
  44. Wang C, Guo H, Liu M. RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese. Clin Exp Rheumatol. 2005;23:379-84 pubmed
    There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients...
  45. Moissidis I, Chinoy B, Yanamandra K, Napper D, Thurmon T, Bocchini J, et al. Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. Genet Med. 2005;7:406-10 pubmed
    IL-13, RANTES (Regulated on Activation, Normal T cells Expressed and Secreted), and cysteinyl leukotrienes are asthma and atopy mediators...
  46. Goulding C, McManus R, Murphy A, Macdonald G, Barrett S, Crowe J, et al. The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut. 2005;54:1157-61 pubmed
    ..The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals...
  47. Chang L, Lin Y, Mahalingam J, Huang C, Chen T, Kang C, et al. Tumor-derived chemokine CCL5 enhances TGF-?-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells. Cancer Res. 2012;72:1092-102 pubmed publisher
    Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to inflammation and malignant progression. In this study, we show that CCL5 plays a critical role in immune escape in colorectal cancer...
  48. Zhao X, Lee S, Wong K, Chan K, Ma S, Yam W, et al. Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese. Eur J Immunogenet. 2004;31:179-83 pubmed
    ..the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China...
  49. Sohn M, Kim S, Kim K, Jee H, Park H, Kim K. RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma. Lung. 2008;186:37-43 pubmed
    Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease...
  50. Eyman D, Damodarasamy M, Plymate S, Reed M. CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis. J Cell Physiol. 2009;220:376-81 pubmed publisher
    ..These data suggest that CCL5 is a candidate chemokine secreted by aged cells that promotes prostate growth and regulates angiogenesis. ..
  51. Tolgyesi G, Keszei M, Ungvári I, Nagy A, Falus A, Szalai C. Involvement of TNFalpha -308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae. Pediatr Res. 2006;60:543-8 pubmed
    ..Tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated on activation normal T cell expressed and secreted) genotypes were determined by PCR-restriction ..
  52. Lachheb J, Chelbi H, Hamzaoui K, Hamzaoui A. Association between RANTES polymorphisms and asthma severity among Tunisian children. Hum Immunol. 2007;68:675-80 pubmed
    The chemokine known as RANTES (regulated upon activation, normal T cells expressed and secreted) is an important element for the chemotaxis at the site of allergic inflammation...
  53. Rathore A, Chatterjee A, Sivarama P, Yamamoto N, Singhal P, Dhole T. Association of RANTES -403 G/A, -28 C/G and In1.1 T/C polymorphism with HIV-1 transmission and progression among North Indians. J Med Virol. 2008;80:1133-41 pubmed publisher
    The relationships between host immune factors and HIV-1 disease progression are still in dispute. The RANTES SNPs exhibit distinct ethnic distribution and are associated with different effects on the course of HIV infection...
  54. Kauts M, Pihelgas S, Orro K, Neuman T, Piirsoo A. CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells. Stem Cell Res. 2013;10:166-78 pubmed publisher
    ..Our data suggest that chemokine signaling via CCR1 may be involved in regulation of stemness of ADSCs...
  55. Mhmoud N, Fahal A, Wendy van de Sande W. Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population. Trop Med Int Health. 2013;18:1119-1127 pubmed publisher
    ..This indicates that the genotypes obtained for CCL5 and IL-10 are associated with an increased risk of developing active TB. ..
  56. Gangwani M, Noel R, Shah A, Rivera Amill V, Kumar A. Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways. J Neuroinflammation. 2013;10:136 pubmed publisher
    ..Furthermore, this effect was observed to be mediated by transcription factors NF-?B and AP-1 and involved the p38-MAPK and PI3K/Akt pathway. ..
  57. Liao C, Yao T, Chung H, See L, Kuo M, Huang J. Polymorphisms in the promoter region of RANTES and the regulatory region of monocyte chemoattractant protein-1 among Chinese children with systemic lupus erythematosus. J Rheumatol. 2004;31:2062-7 pubmed
    ..We investigated whether chemokines such as RANTES (regulated upon activation, normally T cell expressed and secreted) promoter and monocyte chemoattractant protein-..
  58. Vidal F, Peraire J, Domingo P, Broch M, Cairo M, Pedrol E, et al. Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years. J Acquir Immune Defic Syndr. 2006;41:17-22 pubmed
    To examine whether polymorphisms of the RANTES chemokine gene promoter are associated with long-term nonprogressive HIV-1 infection in white Spanish subjects, we performed a cross-sectional genetic association case-control study...
  59. Tavakkoly Bazzaz J, Amiri P, Tajmir Riahi M, Javidi D, Khojasteh Fard M, Taheri Z, et al. RANTES gene mRNA expression and its -403 G/A promoter polymorphism in coronary artery disease. Gene. 2011;487:103-6 pubmed publisher
    Increased RANTES expression has been described to have a role in atherosclerosis plaque formation. Functional polymorphisms within RANTES promoter region have shown association with increased risk of coronary atherosclerosis (CAD)...
  60. de Wit E, van der Merwe L, van Helden P, Hoal E. Gene-gene interaction between tuberculosis candidate genes in a South African population. Mamm Genome. 2011;22:100-10 pubmed publisher
    ..was assessed, focusing on 11 polymorphisms in nine genes (DC-SIGN, IFN-?, IFNGR1, IL-8, IL-1Ra, MBL, NRAMP1, RANTES, and SP-D) that have been associated with TB, some repeatedly...
  61. Suresh P, Wanchu A, Sachdeva R, Bhatnagar A. Gene polymorphisms in CCR5, CCR2, CX3CR1, SDF-1 and RANTES in exposed but uninfected partners of HIV-1 infected individuals in North India. J Clin Immunol. 2006;26:476-84 pubmed
    ..There was no association between CCR5-Delta32, CCR2-64I, CX3CR1-280 M, CX3CR1-249I, SDF-3'A, RANTES-28G and RANTES-403A polymorphisms and susceptibility against HIV in our cohort of EU individuals...
  62. Chuang J, Yang W, Chen H, Huang C, Tan T, Lin Y, et al. CCL5/CCR5 axis promotes the motility of human oral cancer cells. J Cell Physiol. 2009;220:418-26 pubmed publisher
    CCL5 (previously called RANTES) is in the CC-chemokine family and plays a crucial role in the migration and metastasis of human cancer cells. On the other hand, the effect of CCL5 is mediated via CCR receptor...
  63. Huerta C, Alvarez V, Mata I, Coto E, Ribacoba R, Martinez C, et al. Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. Neurosci Lett. 2004;370:151-4 pubmed
    ..We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the ..
  64. Liu Q, Hua L, Fang D, Lin Q, Zhu Y, Gan X, et al. Interleukin-13 and RANTES polymorphisms in relation to asthma in children of Chinese Han nationality. Asian Pac J Allergy Immunol. 2013;31:247-52 pubmed publisher
    IL-13 (interleukin-13) and RANTES (Regulated upon Activation, Normal T cells Expressed and Secreted) are the important asthma inflammatory mediators...
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