Gene Symbol: RANBP10
Description: RAN binding protein 10
Alias: ran-binding protein 10
Species: human
Products:     RANBP10

Top Publications

  1. Rex E, Rankin M, Yang Y, Lu Q, Gerfen C, Jose P, et al. Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. Mol Pharmacol. 2010;78:69-80 pubmed publisher
    ..coimmunoprecipitation approach coupled to mass spectrometry, we report the identification of RanBP9 and RanBP10 as novel interacting proteins for both PKCgamma and PKCdelta...
  2. Palmieri D, Tessari A, Coppola V. Scorpins in the DNA Damage Response. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>SPRY-containing RAN binding Proteins (Scorpins) RANBP9 and RANBP10 are evolutionarily conserved and ubiquitously expressed proteins whose biological functions are still debated...
  3. Hong S, Kim K, Song E, Kim E. Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development. J Mol Biol. 2016;428:4330-4344 pubmed publisher
    RanBPM and RanBP10 are non-canonical members of the Ran binding protein family that lack the Ran binding domain and do not associate with Ran GTPase in vivo...
  4. Liu S, Zhang Y, Gao Y, Zhang L, Chen H, Zhou Q, et al. MiR-378 Plays an Important Role in the Differentiation of Bovine Preadipocytes. Cell Physiol Biochem. 2015;36:1552-62 pubmed
    ..E2F transcription factor 2 (E2F2) and Ras-related nuclear (RAN)-binding protein 10 (RANBP10) were the two target genes of miR-378...
  5. Wang D, Li Z, Schoen S, Messing E, Wu G. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Biochem Biophys Res Commun. 2004;313:320-6 pubmed
    ..We subsequently named this protein RanBP10 after demonstrating its interaction with Ran...
  6. Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
    ..2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif. ..
  7. Sato Y, Kato A, Maruzuru Y, Oyama M, Kozuka Hata H, Arii J, et al. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication. J Virol. 2016;90:3173-86 pubmed publisher
    ..spectrometry-based proteomics technology and subsequent analyses showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in HSV-1-infected cells...
  8. Wang D, Li Z, Messing E, Wu G. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J Biol Chem. 2002;277:36216-22 pubmed
    ..Our data suggest that RanBPM, functioning as an adaptor protein for the MET tyrosine kinase domain, can augment the HGF-MET signaling pathway and that RanBPM overexpression may cause constitutive activation of the Ras signaling pathway. ..
  9. Her L, Mao S, Chang C, Cheng P, Chang Y, Yang H, et al. miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease. Theranostics. 2017;7:2452-2462 pubmed publisher
    ..Additionally, we found that miR-196a could suppress the expression of RAN binding protein 10 (RANBP10) through binding to its 3' untranslated region, and higher expression of RANBP10 exacerbates ..

More Information


  1. Schulze H, Dose M, Korpal M, Meyer I, Italiano J, Shivdasani R. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008;283:14109-19 pubmed publisher
    ..Here we identify a cytoplasmic Ran-binding protein, RanBP10, as a factor that binds beta-tubulin and associates with megakaryocyte microtubules...