RAET1E

Summary

Gene Symbol: RAET1E
Description: retinoic acid early transcript 1E
Alias: LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4, bA350J20.7, retinoic acid early transcript 1E, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, lymphocyte effector toxicity activation ligand
Species: human
Products:     RAET1E

Top Publications

  1. Radosavljevic M, Cuillerier B, Wilson M, Clement O, Wicker S, Gilfillan S, et al. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics. 2002;79:114-23 pubmed
    ..Hence we have named the identified loci RAET1E-N...
  2. Achiron R, Gilboa Y, Salem Y, Jacobson Y, Raviv Zilka L, Cioca A, et al. Primary Fetal Lung Hypoplasia (PFLH): Imaging and Clinical Characteristics. Ultraschall Med. 2017;38:301-309 pubmed publisher
    ..b>Schlussfolgerung?Die primäre PFLH ist eine seltene Anomalie, die in ihrer bilateralen Ausprägung letal verläuft und bei der die unilaterale Variante eine sehr variable Prognose hat...
  3. Altun A, Saraydin S, Soylu S, Inan D, Yasti C, Ozdenkaya Y, et al. Chemopreventive effects of hydatid disease on experimental breast cancer. Asian Pac J Cancer Prev. 2015;16:1391-5 pubmed
    Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches...
  4. Cho H, Chung J, Kim S, Braunschweig T, Kang T, Kim J, et al. MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer. BMC Cancer. 2014;14:957 pubmed publisher
    ..Immunohistochemical analyses of MICA/B, ULBP1, ULBP2, ULBP3, RAET1E, and RAET1G were performed using tissue microarray analysis of 200 cervical cancers, 327 high-grade cervical ..
  5. Xu L, Fang J, Weng W, Xu H. Critical role of sensitized serum in rejection of allogeneic bone marrow cells. Turk J Haematol. 2014;31:266-71 pubmed publisher
    ..Sensitize serum ile inkübe edilmiş kemik iliği hücreleri fareleri letal dozda irradiasyondan korumakta başarısız olmuştur...
  6. Kotel nikova O, Alliluev A, Drozhzhina E, Koroleva I, Sitnikova E, Zinchenko A, et al. [Protective properties of recombinant IgA1 protease from meningococcus]. Biomed Khim. 2014;60:479-86 pubmed
    ..meningokokkovoÄ­ infektsii, vyzyvaemoÄ­ meningokokkami serogrupp A, V i S, zashchishchaia mysheÄ­ ot letal'nogo zarazheniia zhivoÄ­ virulentnoÄ­ kul'turoÄ­ geterologichnykh serogrupp meningokokka...
  7. Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka K, et al. Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms. J Histochem Cytochem. 2015;63:217-27 pubmed publisher
    ..In contrast, MICA/B, as well as ULBP4, did not appear to be related to any other ligand...
  8. Valls Serón M, Ferwerda B, Engelen Lee J, Geldhoff M, Jaspers V, Zwinderman A, et al. V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. Acta Neuropathol Commun. 2016;4:50 pubmed publisher
    ..study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 (DCTN4), retinoic acid early transcript 1E (RAET1E), and V-akt murine thymoma viral oncogene homolog 3 (AKT3) to be associated with ..
  9. Herrera Fernández F, Palomeque Jiménez A, Serrano Puche F, Calzado Baeza S, Reyes Moreno M. [Rupture of splenic artery pseudoaneurysm: an unusual cause of upper gastrointetinal bleeding]. Cir Cir. 2014;82:551-5 pubmed
    ..Conclusión: en raras ocasiones la ruptura de un pseudoaneurisma de la arteria esplénica puede iniciarse como una hemorragia digestiva alta, que puede ser letal si no es tratada con urgencia.

More Information

Publications33

  1. Lanier L. NKG2D Receptor and Its Ligands in Host Defense. Cancer Immunol Res. 2015;3:575-82 pubmed publisher
    ..the receptor recognizes an extensive repertoire of ligands, encoded by at least eight genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism...
  2. Polak R, Dacey M, Phillips E. Time for food - training physiatrists in nutritional prescription. J Rehabil Med. 2017;49:106-112 pubmed publisher
    ..chronic diseases, and various health conditions that are treated by physiatrists, such as stroke and musculoske-letal disorders...
  3. Voronin V, Dudin A. [THE DESCRIPTION OF MYXOBOLUS PELECICOLA SP. NOV. (MYXOZOA: MYXOBOLIDAE) FROM PELECUS CULTRATUS (CYPRINIFORMES, CYPRINIDAE)]. Parazitologiia. 2015;49:257-63 pubmed
    ..Polysporous, el- lipsoidal. plasmodia up to 1.2 mm in length and 0.1 to 0.4 mm in width develop in the ske- letal musculature. Mature spores elongate oval or oval form in frontal view, lens-shaped in sutural view...
  4. Djelloul M, Popa N, Pelletier F, Raguenez G, Boucraut J. RAE-1 expression is induced during experimental autoimmune encephalomyelitis and is correlated with microglia cell proliferation. Brain Behav Immun. 2016;58:209-217 pubmed publisher
    ..the time course expression of the two members of the Raet1 gene family present in C57BL/6 mice, namely Raet1d and Raet1e, in the spinal cord during EAE...
  5. Rancan C, Schirrmann L, Hüls C, Zeidler R, Moosmann A. Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells. PLoS Pathog. 2015;11:e1004906 pubmed publisher
    ..Specifically, the agonistic NKG2D ligands MICA and ULBP4 were increased...
  6. Eagle R, Traherne J, Hair J, Jafferji I, Trowsdale J. ULBP6/RAET1L is an additional human NKG2D ligand. Eur J Immunol. 2009;39:3207-16 pubmed publisher
    ..Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. Comparison of ULBP6 with ULBP4 and ULBP5 indicated that differences in recombinant NKG2D binding correlated with differences in NK-cell ..
  7. Han B, Zhao Y, Lin Y, Fu S, Wang L, Zhang M, et al. Hydroxychloroquine sensitizes chronic myeloid leukemia cells to Vγ9Vδ2 T cell-mediated lysis independent of autophagy. Int J Oncol. 2017;50:1810-1820 pubmed publisher
    ..We revealed that in a time-dependent manner HCQ induced the expression of NKG2D ligand ULBP4 on the surface of CML cells. This marks the leukemia cell for recognition by Vγ9Vδ2 T cells...
  8. Bacon L, Eagle R, Meyer M, Easom N, Young N, Trowsdale J. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. J Immunol. 2004;173:1078-84 pubmed
    We characterized two novel members of the RAET1/ULBP gene cluster, RAET1E and RAET1G...
  9. Conejo Garcia J, Benencia F, Courreges M, Gimotty P, Khang E, Buckanovich R, et al. Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells. Cancer Res. 2004;64:2175-82 pubmed
    ..Human ovarian carcinoma expresses the novel NKG2D ligand lymphocyte effector cell toxicity-activating ligand (Letal). Letal was found to be an independent prognosticator of improved survival in advanced ovarian cancer...
  10. Xu Y, Zhou L, Zong J, Ye Y, Chen G, Chen Y, et al. Decreased expression of the NKG2D ligand ULBP4 may be an indicator of poor prognosis in patients with nasopharyngeal carcinoma. Oncotarget. 2017;8:42007-42019 pubmed publisher
    U16-binding protein 4 (ULBP4), a human ligand for natural killer group 2, member D (NKG2D) receptor on NK cells and subsets of T cells, is thought to activate anticancer immune responses...
  11. Subramanian N, Wu Z, Reister F, Sampaio K, Frascaroli G, Cicin Sain L, et al. Naïve T cells are activated by autologous HCMV-infected endothelial cells through NKG2D and can control HCMV transmission in vitro. J Gen Virol. 2017;: pubmed publisher
    ..receptor was blocked on the surface of T cells and among the different NKG2D ligands, we identified two ligands (ULBP4 and MICA) on HCMV-infected HUVECs which might be the interaction partners of the NKG2D receptor...
  12. Antoun A, Jobson S, Cook M, O callaghan C, Moss P, Briggs D. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. Hum Immunol. 2010;71:610-20 pubmed publisher
    ..Interestingly, variation was focused within the RAET1E (ULBP4), RAET1L, and ULBP3 genes, whereas the ULBP1, ULBP2 and RAET1G (ULBP5) genes were highly conserved...
  13. McGilvray R, Eagle R, Rolland P, Jafferji I, Trowsdale J, Durrant L. ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients. Int J Cancer. 2010;127:1412-20 pubmed publisher
    ..Patients whose tumors had high expression of RAET1E (p = 0.037), ULBP1 (p = 0.036) and ULBP3 (p = 0...
  14. Romphruk A, Romphruk A, Naruse T, Raroengjai S, Puapairoj C, Inoko H, et al. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. Immunogenetics. 2009;61:611-7 pubmed publisher
    ..The human RAET1/ULBP gene family is identified as ten members (RAET1E to N) with six loci encoding for potentially functional proteins...
  15. Kong Y, Cao W, Xi X, Ma C, Cui L, He W. The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D. Blood. 2009;114:310-7 pubmed publisher
    ..We previously reported that RAET1E2, a soluble isoform of the RAET1E (ULBP4), inhibits NKG2D-mediated NK cytotoxicity...
  16. Pearson H, Madrigal J, Saudemont A, Cox S. Increasing polymorphism of the RAET1E/ULBP4 gene in humans. HLA. 2016;87:63-5 pubmed publisher
    Description of three novel RAET1E/ULBP4 allele and promoter polymorphisms identified by sequence-based typing.
  17. Zuo J, Willcox C, Mohammed F, Davey M, Hunter S, Khan K, et al. A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. Sci Signal. 2017;10: pubmed publisher
    ..Our results reveal that ULBP polymorphisms affect the strength of human lymphocyte responses to cellular stress signals and may offer opportunities for therapeutic intervention. ..
  18. Conejo Garcia J, Benencia F, Courreges M, Khang E, Zhang L, Mohamed Hadley A, et al. Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther. 2003;2:446-51 pubmed
    ..in peripheral tissues. Here we report the characterization of Letal, the first human trans-membrane NKG2D ligand lacking an immunoglobulin-like alpha-3 ectodomain...
  19. Cox S, Pearson H, Laza Briviesca R, Pesoa S, Vullo C, Madrigal J, et al. Characterization of 5' promoter and exon 1-3 polymorphism of the RAET1E gene. Hum Immunol. 2016;77:96-103 pubmed publisher
    ..We carried out RAET1E typing of IHW cell line DNA, including a 580 bp proximal promoter fragment and exons 1-3 identifying 13 of 15 ..
  20. Cao W, Xi X, Wang Z, Dong L, Hao Z, Cui L, et al. Four novel ULBP splice variants are ligands for human NKG2D. Int Immunol. 2008;20:981-91 pubmed publisher
    ..In this study, we identified four novel functional splice variants of ULBPs including ULBP4-I, ULBP4-II, ULBP4-III and RAET1G3 in HepG2 liver carcinoma cells, WISH human amnion cells, Hep-2 larynx carcinoma ..
  21. Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, et al. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. J Biol Chem. 2007;282:18922-8 pubmed
    ..In this study, we report that RAET1E can produce a soluble, 35-kDa protein (termed as RAET1E2) lacking the transmembrane region by selective splicing in tumor cells...
  22. Vadstrup K, Galsgaard E, Jensen H, Lanier L, Ryan J, Chen S, et al. NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration. Exp Mol Pathol. 2017;103:56-70 pubmed publisher
    ..study, we further characterize the expression of NKG2D and its ligands, including the less well-described ULBP4-6, in CD, and test if NKG2D ligand interactions are involved in the migration of activated T cells into the ..
  23. Franco Marcelino P, da Silva V, Rodrigues Philippini R, Von Zuben C, Contiero J, dos Santos J, et al. Biosurfactants produced by Scheffersomyces stipitis cultured in sugarcane bagasse hydrolysate as new green larvicides for the control of Aedes aegypti, a vector of neglected tropical diseases. PLoS ONE. 2017;12:e0187125 pubmed publisher
    ..the produced biosurfactant caused destruction to the larval exoskeletons 12 h after application and presented an letal concentration (LC50) of 660 mg.L-1...
  24. Chalupny N, Sutherland C, Lawrence W, Rein Weston A, Cosman D. ULBP4 is a novel ligand for human NKG2D. Biochem Biophys Res Commun. 2003;305:129-35 pubmed
    ..Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked ..