RAD51D

Summary

Gene Symbol: RAD51D
Description: RAD51 paralog D
Alias: BROVCA4, R51H3, RAD51L3, TRAD, DNA repair protein RAD51 homolog 4, RAD51 homolog D, RAD51-like protein 3, recombination repair protein
Species: human
Products:     RAD51D

Top Publications

  1. Schild D, Lio Y, Collins D, Tsomondo T, Chen D. Evidence for simultaneous protein interactions between human Rad51 paralogs. J Biol Chem. 2000;275:16443-9 pubmed
    ..Five human Rad51 paralogs have been identified (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C/Rad51L2, and Rad51D/Rad51L3), and each interacts with one or more of the others...
  2. Masson J, Tarsounas M, Stasiak A, Stasiak A, Shah R, McIlwraith M, et al. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes Dev. 2001;15:3296-307 pubmed
    Cells defective in any of the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) are sensitive to DNA cross-linking agents and to ionizing radiation...
  3. Kurumizaka H, Ikawa S, Nakada M, Enomoto R, Kagawa W, Kinebuchi T, et al. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. J Biol Chem. 2002;277:14315-20 pubmed
    The Xrcc2 and Rad51D/Rad51L3 proteins, which belong to the Rad51 paralogs, are required for homologous recombinational repair (HRR) in vertebrates...
  4. Miller K, Sawicka D, Barsky D, Albala J. Domain mapping of the Rad51 paralog protein complexes. Nucleic Acids Res. 2004;32:169-78 pubmed
    ..These proteins have been found to form two distinct complexes in vivo, Rad51B-Rad51C-Rad51D-Xrcc2 (BCDX2) and Rad51C-Xrcc3 (CX3)...
  5. Wickramanayake A, Wickramanyake A, Bernier G, Pennil C, Casadei S, Agnew K, et al. Loss of function germline mutations in RAD51D in women with ovarian carcinoma. Gynecol Oncol. 2012;127:552-5 pubmed publisher
    b>RAD51D, a gene in the Fanconi Anemia-BRCA homologous recombination pathway, has recently been shown to harbor germline mutations responsible for ovarian carcinoma in multiply affected families...
  6. Braybrooke J, Spink K, Thacker J, Hickson I. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. J Biol Chem. 2000;275:29100-6 pubmed
    ..We demonstrate that the purified RAD51L3 protein possesses single-stranded DNA binding activity and DNA-stimulated ATPase activity, consistent with the ..
  7. Miller K, Yoshikawa D, McConnell I, Clark R, Schild D, Albala J. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. J Biol Chem. 2002;277:8406-11 pubmed
    ..showed that RAD51C is central to a single large protein complex and/or several smaller complexes with RAD51B, RAD51D, XRCC2, and XRCC3. However, our experiments showed no evidence for the inclusion of RAD51 within these complexes...
  8. Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala J, Sung P. Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. Genes Dev. 2001;15:3308-18 pubmed
    ..The competition by RPA for substrate binding can be partially alleviated by Rad51B-Rad51C. This recombination mediator function of Rad51B-Rad51C is likely required for the assembly of the Rad51-ssDNA nucleoprotein filament in vivo. ..
  9. Wiese C, Collins D, Albala J, Thompson L, Kronenberg A, Schild D. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. Nucleic Acids Res. 2002;30:1001-8 pubmed
    ..is likely to require Rad51 and the five Rad51 paralogs (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C/Rad51L2 and Rad51D/Rad51L3), as has been shown in chicken and rodent cells...

More Information

Publications136 found, 100 shown here

  1. Liu N, Schild D, Thelen M, Thompson L. Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. Nucleic Acids Res. 2002;30:1009-15 pubmed
    ..mutant cell lines have suggested that Rad51 paralogs (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C/Rad51L2 and Rad51D/Rad51L3) play important roles in homologous recombinational repair of DNA double-strand breaks and in maintaining ..
  2. Braybrooke J, Li J, Wu L, Caple F, Benson F, Hickson I. Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). J Biol Chem. 2003;278:48357-66 pubmed
    ..Here, we show that BLM also makes a direct physical association with the RAD51L3 protein (also known as RAD51D), a so-called RAD51 paralog that shows limited sequence similarity to RAD51 itself...
  3. Rodrigue A, Lafrance M, Gauthier M, McDonald D, Hendzel M, West S, et al. Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J. 2006;25:222-31 pubmed
    ..The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) play important roles in this process...
  4. Loveday C, Turnbull C, Ramsay E, Hughes D, Ruark E, Frankum J, et al. Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet. 2011;43:879-882 pubmed publisher
    ..This observation prompted us to investigate the role of RAD51D in cancer susceptibility...
  5. Osher D, De Leeneer K, Michils G, Hamel N, Tomiak E, Poppe B, et al. Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families. Br J Cancer. 2012;106:1460-3 pubmed publisher
    Recent data show that mutations in RAD51D have an aetiological role in ovarian carcinoma, yet mutations do not appear to be associated with an increased risk for breast cancer...
  6. Chun J, Buechelmaier E, Powell S. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol. 2013;33:387-95 pubmed publisher
    ..The Rad51 paralogs associate with one another in two distinct complexes: Rad51B-Rad51C-Rad51D-XRCC2 (BCDX2) and Rad51C-XRCC3 (CX3)...
  7. Potter R, Wallace M, McMullen A, Prusa J, Stallings C, Burnham C, et al. blaIMP-27 on transferable plasmids in Proteus mirabilis and Providencia rettgeri. Clin Microbiol Infect. 2018;24:1019.e5-1019.e8 pubmed publisher
    ..pPM187 had a virB/virD4 type IV secretion system whereas pPR1 had a traB/traD type IV secretion system...
  8. Catts Z, Baig M, Milewski B, Keywan C, Guarino M, Petrelli N. Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds. Ann Surg Oncol. 2016;23:1729-35 pubmed publisher
    ..Specifically, the mutations were found in 1/25 = ATM (4 %), 1/25 = CHEK2 (4 %), and 1/25 = RAD51D (4 %). Affected probands (n = 23) Lastly, all 23 probands affected with PC pursued genetic testing...
  9. Mary C, Fouillen A, Bessette B, Nanci A, Baron C. Interaction via the N terminus of the type IV secretion system (T4SS) protein VirB6 with VirB10 is required for VirB2 and VirB5 incorporation into T-pili and for T4SS function. J Biol Chem. 2018;293:13415-13426 pubmed publisher
    ..tumefaciens, and the corresponding deletions in the VirB6 homolog TraD from the plasmid pKM101-T4SS abrogated plasmid transfer...
  10. Manchanda R, Gaba F. Population Based Testing for Primary Prevention: A Systematic Review. Cancers (Basel). 2018;10: pubmed publisher
    ..Population panel testing for BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 gene mutations is the most cost-effective genetic-testing strategy in general-population women and ..
  11. Lovecek M, Janatova M, Skalický P, Zemánek T, Havlik R, Ehrmann J, et al. Genetic analysis of subsequent second primary malignant neoplasms in long-term pancreatic cancer survivors suggests new potential hereditary genetic alterations. Cancer Manag Res. 2019;11:599-609 pubmed publisher
    ..PDAC survivors, 3 patients (19%) carried germline mutation(s) in the MLH1+ ATM, CHEK2, and RAD51D gene, respectively...
  12. Sullivan M, Bernstein K. RAD-ical New Insights into RAD51 Regulation. Genes (Basel). 2018;9: pubmed publisher
    ..Mutations in the human RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, and SWSAP1) are found in a subset of breast and ovarian cancers...
  13. Wahner Hendrickson A, Menefee M, Hartmann L, Long H, Northfelt D, Reid J, et al. A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors. Clin Cancer Res. 2018;24:744-752 pubmed publisher
    ..Patients with germline BRCA1, BRCA2, or RAD51D mutations remained on study longer than those without homologous recombination repair (HRR) gene mutations (..
  14. Suszynska M, Klonowska K, Jasinska A, Kozlowski P. Large-scale meta-analysis of mutations identified in panels of breast/ovarian cancer-related genes - Providing evidence of cancer predisposition genes. Gynecol Oncol. 2019;153:452-462 pubmed publisher
    ..g., RAD51C, and RAD51D)...
  15. Lilyquist J, Laduca H, Polley E, Davis B, Shimelis H, Hu C, et al. Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls. Gynecol Oncol. 2017;147:375-380 pubmed publisher
    ..ovarian cancer, with eight of these displaying ≥5-fold increased risk (BRCA1, BRCA2, BRIP1, MSH2, MSH6, RAD51C, RAD51D)...
  16. Timmerby N, Austin S, Bech P. [Positive psychiatry]. Ugeskr Laeger. 2016;178:V09150759 pubmed
    ..PP should be considered a supplement to trad-tional psychiatry and a call for therapists in psychiatry to focus on the person as a whole rather than just as a ..
  17. Machitani M, Sakurai F, Wakabayashi K, Tachibana M, Fujiwara T, Mizuguchi H. Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer. Mol Cancer Ther. 2017;16:251-259 pubmed publisher
    ..Among the various types of oncolytic viruses, the telomerase-specific replication-competent adenovirus (TRAD), which carries the tumor-specific promoter-driven E1 gene expression cassette, exhibits efficient antitumor ..
  18. Eoh K, Kim J, Park H, Lee S, Park J, Han J, et al. Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-gene Panels: Beyond BRCA1/2. Cancer Res Treat. 2018;50:917-925 pubmed publisher
    ..genes, including BRCA1 (n=21), BRCA2 (n=10), BRIP1 (n=1), CHEK2 (n=2), MSH2 (n=1), POLE (n=1), RAD51C (n=2), and RAD51D (n=2). Among 64 patients with a family history of cancer, 27 (42...
  19. Charlot F, Chelysheva L, Kamisugi Y, Vrielynck N, Guyon A, Epert A, et al. RAD51B plays an essential role during somatic and meiotic recombination in Physcomitrella. Nucleic Acids Res. 2014;42:11965-78 pubmed publisher
    ..Rad51-like proteins have been identified in yeast (Rad55, Rad57 and Dmc1), plants and vertebrates (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 and DMC1)...
  20. Clark A, De La Rosa A, DeRevere J, Astorino T. Effects of various interval training regimes on changes in maximal oxygen uptake, body composition, and muscular strength in sedentary women with obesity. Eur J Appl Physiol. 2019;119:879-888 pubmed publisher
    We determined the effects of two high-intensity interval training (HIIT) regimens [the traditional (TRAD) and periodized (PER)] on changes in maximal oxygen uptake (VO2max), body composition, and muscular strength in sedentary, ..
  21. Liu X, Sun C, Jin X, Li P, Ye F, Zhao T, et al. Genistein enhances the radiosensitivity of breast cancer cells via G₂/M cell cycle arrest and apoptosis. Molecules. 2013;18:13200-17 pubmed publisher
    ..Significantly increased DNA damages, arrested cells at G₂/M phase, decreased homologous recombination repair protein Rad51 foci formation and enhanced apoptotic rates were observed in both cell lines treated by genistein ..
  22. Hjortkjær M, Malik Aagaard Jørgensen M, Waldstrøm M, Ørnskov D, Søgaard Andersen E, Jakobsen A, et al. The clinical importance of BRCAness in a population-based cohort of Danish epithelial ovarian cancer. Int J Gynecol Cancer. 2019;29:166-173 pubmed publisher
    ..8%) and/or somatic (6.3%) mutation in 12 (BRCA1, BRCA2, CHEK2, ATM, RAD51D, EMSY, PALB2, BRIP1, ERCC1, RAD50, ATR, RAD51C) of 18 ..
  23. Langerud J, Jarhelle E, Van Ghelue M, Ariansen S, Iversen N. Trans-activation-based risk assessment of BRCA1 BRCT variants with unknown clinical significance. Hum Genomics. 2018;12:51 pubmed publisher
    ..The modified TA assay provides efficient risk assessment of rare missense variants found in the BRCA1 BRCT-domains. We also report that increased post-transfection incubation time yielded a significant increase in TA assay sensitivity. ..
  24. Horwath O, Paulsen G, Esping T, Seynnes O, Olsson M. Isokinetic resistance training combined with eccentric overload improves athletic performance and induces muscle hypertrophy in young ice hockey players. J Sci Med Sport. 2019;: pubmed publisher
    ..to either isokinetic resistance training and eccentric overload (ISO/ECC; n=11) or traditional resistance training (TRAD; n=11)...
  25. Ishida S, Tien L, Osawa R, Tohya M, Nomoto R, Kawamura Y, et al. Development of an appropriate PCR system for the reclassification of Streptococcus suis. J Microbiol Methods. 2014;107:66-70 pubmed publisher
    ..Therefore, recN PCR described in the present study will be a useful tool for the identification of authentic S. suis, and can also be used in epidemiological studies on this bacterium. ..
  26. Oji Y, Tatsumi N, Kobayashi J, Fukuda M, Ueda T, Nakano E, et al. Wilms' tumor gene WT1 promotes homologous recombination-mediated DNA damage repair. Mol Carcinog. 2015;54:1758-71 pubmed publisher
    ..WT1[17AA(-)KTS(+)] isoform significantly upregulated the expression of HR genes, XRCC2, Rad51D, and Rad54...
  27. Santos A, Segura Muñoz S, Nadal M, Schuhmacher M, Domingo J, Martinez C, et al. Traffic-related air pollution biomonitoring with Tradescantia pallida (Rose) Hunt. cv. purpurea Boom in Brazil. Environ Monit Assess. 2015;187:39 pubmed publisher
    ..Additionally, micronucleus assay with early pollen tetrad cells of Tradescantia (Trad-MN) was conducted by collecting flower buds and analyzing the micronuclei frequencies in pollen mother cells...
  28. Moretta J, Berthet P, Bonadona V, Caron O, Cohen Haguenauer O, Colas C, et al. [The French Genetic and Cancer Consortium guidelines for multigene panel analysis in hereditary breast and ovarian cancer predisposition]. Bull Cancer. 2018;105:907-917 pubmed publisher
    ..were selected to be included in a HBOC diagnosis gene panel: BRCA1, BRCA2, PALB2, TP53, CDH1, PTEN, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2, EPCAM...
  29. de Brito K, de Lemos C, Rocha J, Mielli A, Matzenbacher C, Vargas V. Comparative genotoxicity of airborne particulate matter (PM2.5) using Salmonella, plants and mammalian cells. Ecotoxicol Environ Saf. 2013;94:14-20 pubmed publisher
    ..2) was evaluated using microsuspension assays in Salmonella/microsome, micronucleus test with Tradescantia pallida (Trad-MN) with acute exposure, and in V79 (V79-MN) cells, Comet assay in V79 and human lymphocyte, besides Trad-MN in ..
  30. Andrews L, Mutch D. Hereditary Ovarian Cancer and Risk Reduction. Best Pract Res Clin Obstet Gynaecol. 2017;41:31-48 pubmed publisher
    ..Despite next-generation sequencing, other identified genes (Lynch Syndrome, RAD51C, RAD51D, and BRIP1) account for only a small proportion of cases...
  31. Placencia F, Fadic X, Yáñez K, Cereceda Balic F. Tradescantia as a biomonitor for genotoxicity evaluation of diesel and biodiesel exhaust emissions. Sci Total Environ. 2019;651:2597-2605 pubmed publisher
    ..chamber called the BioToxMonitor, where Tradescantia pallida and a KU-20 clone were exposed to exhaust following Trad-MCN and Trad-SH bioassays...
  32. Golmard L, Castera L, Krieger S, Moncoutier V, Abidallah K, Tenreiro H, et al. Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers. Eur J Hum Genet. 2017;25:1345-1353 pubmed publisher
    RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have recently been involved in breast and ovarian cancer predisposition: RAD51B, RAD51C, and RAD51D in ovarian cancer, RAD51B and XRCC2 in breast cancer...
  33. Turnbull C, Sud A, Houlston R. Cancer genetics, precision prevention and a call to action. Nat Genet. 2018;50:1212-1218 pubmed publisher
    ..were subsequently identified by mutation screening of candidate genes (PALB2, ATM, CHEK2, BRIP1, RAD51C and RAD51D)...
  34. Saxena S, Somyajit K, Nagaraju G. XRCC2 Regulates Replication Fork Progression during dNTP Alterations. Cell Rep. 2018;25:3273-3282.e6 pubmed publisher
    ..Here, we find that a subset of RAD51 paralogs, XRCC2 (FANCU) and its binding partner RAD51D, restrain active DNA synthesis during dinucleotide triphosphate (dNTP) alterations in a manner independent of HDR...
  35. Charasseangpaisarn T, Wiwatwarrapan C. The effect of various frequencies of ultrasonic cleaner in reducing residual monomer in acrylic resin. Ultrasonics. 2015;63:163-7 pubmed publisher
    ..Forty-two specimens each of Meliodent heat-polymerized acrylic resin (M) and Unifast Trad Ivory auto-polymerized acrylic resin (U) were prepared according to their manufacturer's instructions and randomly ..
  36. Zia S, Singh K, Juneja A, Schor J, Deitch J. Safety and Feasibility of Transradial Access for Noncoronary and Peripheral Vascular Interventions. Ann Vasc Surg. 2018;53:255-261 pubmed publisher
    Transradial access (TRad) is becoming the preferred access for cardiac catheterization. The use and safety of TRad in noncoronary and peripheral vascular interventions remains ill-defined and serves as the basis for this study...
  37. Hoyer J, Vasileiou G, Uebe S, Wunderle M, Kraus C, Fasching P, et al. Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria. BMC Cancer. 2018;18:926 pubmed publisher
    ..low-moderate penetrance breast cancer susceptibility genes (BRCA1, BRCA2, ATM, CDH1, CHEK2, NBN, PALB2, RAD51C, RAD51D and TP53) in 229 consecutive individuals affected with TNBC unselected for age, family history or bilateral ..
  38. Bonache S, Esteban I, Moles Fernández A, Tenés A, Duran Lozano L, Montalban G, et al. Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings. J Cancer Res Clin Oncol. 2018;144:2495-2513 pubmed publisher
    ..identified 16 patients who carried a high- or moderate-risk pathogenic variant in eight genes: 4 PALB2, 3 ATM, 2 RAD51D, 2 TP53, 2 APC, 1 BRIP1, 1 PTEN and 1 PMS2...
  39. Couch F, Hart S, Sharma P, Toland A, Wang X, Miron P, et al. Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer. J Clin Oncol. 2015;33:304-11 pubmed publisher
    ..2%) and BARD1, RAD51D, RAD51C, and BRIP1 (0.3% to 0.5%). Patients with TNBC with mutations were diagnosed at an earlier age (P < ...
  40. Domagala P, Jakubowska A, Jaworska Bieniek K, Kaczmarek K, Durda K, Kurlapska A, et al. Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers. PLoS ONE. 2015;10:e0130393 pubmed publisher
    ..e., BRCA1, BRCA2, CHEK2, NBN, ATM, PALB2, BARD1, and RAD51D, in 202 consecutive patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers...
  41. Afghahi A, Telli M, Kurian A. Genetics of triple-negative breast cancer: Implications for patient care. Curr Probl Cancer. 2016;40:130-140 pubmed publisher
    ..in several moderate penetrance breast cancer susceptibility genes, including PALB2, BARD1, BRIP1, RAD51C and RAD51D. Interestingly, many of these genes, like BRCA1/2, are involved in homologous recombination DNA double-stranded ..
  42. Castera L, Harter V, Muller E, Krieger S, Goardon N, Ricou A, et al. Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families. Genet Med. 2018;20:1677-1686 pubmed publisher
    ..Odds ratio conferred by PVs within BRCA1, BRCA2, PALB2, RAD51C, RAD51D, ATM, BRIP1, CHEK2, and MSH6 were estimated at 13.22 [10.01-17.22], 8.61 [6.78-10.82], 8.22 [4.91-13.05], 4.54 [2...
  43. Frimer M, Levano K, Rodriguez Gabin A, Wang Y, Goldberg G, Horwitz S, et al. Germline mutations of the DNA repair pathways in uterine serous carcinoma. Gynecol Oncol. 2016;141:101-7 pubmed publisher
    ..Five patients harbored 7 germline mutations (33.3%) within genes involved in the HR pathway, RAD51D being the most common. Four patients had 9 (42...
  44. Kleibl Z, Kristensen V. Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management. Breast. 2016;28:136-44 pubmed publisher
    ..TP53, STK11/LKB1, CDH1, PALB2, CHEK2, ATM, MRE11, RAD50, NBS1, BRIP1, FANCA, FANCC, FANCM, RAD51, RAD51B, RAD51C, RAD51D, and XRCC2 have been described as high- or moderate-penetrance breast cancer-susceptibility genes...
  45. Tedaldi G, Tebaldi M, Zampiga V, Danesi R, Arcangeli V, Ravegnani M, et al. Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer. Oncotarget. 2017;8:47064-47075 pubmed publisher
    ..mutation in BRCA1/2 genes, and 17 carried pathogenic mutations in other genes, such as PALB2, ATM, BRIP1, RAD51D, MSH6, PPM1D, RECQL4, ERCC3, TSC2, SLX4 and other Fanconi anemia genes...
  46. Focht B, Garver M, Devor S, Dials J, Lucas A, Emery C, et al. Group-mediated physical activity promotion and mobility in sedentary patients with knee osteoarthritis: results from the IMPACT-pilot trial. J Rheumatol. 2014;41:2068-77 pubmed publisher
    ..a group-mediated cognitive behavioral exercise intervention (GMCB) with traditional center-based exercise therapy (TRAD) on objectively assessed levels of physical activity (PA) and mobility in sedentary patients with knee ..
  47. Wang J, Zeng Z, Huang X, Ma Z, Guo Z, Lv L, et al. Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying blaCTX-M-55 or blaCTX-M-65 in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China. mSphere. 2018;3: pubmed publisher
    ..replication, leading, and conjugative transfer regions and differed by the numbers of repeats in yddA and traD and by the presence of group II intron, except that pHNAH9 lacked a large segment of the leading and transfer ..
  48. Li J, Meeks H, Feng B, Healey S, Thorne H, Makunin I, et al. Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families. J Med Genet. 2016;53:34-42 pubmed publisher
    ..and 22 potential deleterious mutations in 31 cases in 8 other genes (BARD1, BRIP1, MRE11, NBN, RAD50, RAD51C, RAD51D and CDK4). The relevant variants were then genotyped in 558 family members...
  49. Rocha A, Cândido L, Pereira J, Silva C, da Silva S, Mussury R. Evaluation of vehicular pollution using the TRAD-MCN mutagenic bioassay with Tradescantia pallida (Commelinaceae). Environ Pollut. 2018;240:440-447 pubmed publisher
    ..The objectives of this study was to estimate the mutagenic potential of vehicular flow through the TRAD-MCN bioassay in cities located at different altitudes in the southwest mesoregion of Mato Grosso do Sul, Brazil, to ..
  50. Xu M, Liu S, Zheng B, Wu J, Wu M, Zhang Y, et al. The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair. Pancreatology. 2018;18:822-832 pubmed publisher
    ..in DNA damage repair, including UBE2T, RPA1, GTF2HH5, LIG1, POLD3, RMI2, XRCC1, PRKDC, FANC1, FAAP100, RAD50, RAD51D, RAD51B and DMC1, through JNK, ERK, PKC, p38 and/or NF-κB pathway dependent manners...
  51. Arai S, Tohya M, Yamada R, Osawa R, Nomoto R, Kawamura Y, et al. Development of loop-mediated isothermal amplification to detect Streptococcus suis and its application to retail pork meat in Japan. Int J Food Microbiol. 2015;208:35-42 pubmed publisher
    ..These results suggest that LAMPSS will be a useful tool for the surveillance of raw pork meat in the retail market. ..
  52. Meßler C, Holmberg H, Sperlich B. Multimodal Therapy Involving High-Intensity Interval Training Improves the Physical Fitness, Motor Skills, Social Behavior, and Quality of Life of Boys With ADHD: A Randomized Controlled Study. J Atten Disord. 2016;: pubmed
    ..therapy including supervised high-intensity interval training (HIIT) with those of standard multimodal therapy (TRAD) concerning key variables of physical fitness (peak power and oxygen uptake), motor skills, social behavior, and ..
  53. Luengwilai K, Beckles D, Siriphanich J. Postharvest internal browning of pineapple fruit originates at the phloem. J Plant Physiol. 2016;202:121-33 pubmed publisher
    ..After three weeks of chilling exposure, the cultivars 'MD2' showed 0%, 'Pattavia' and 'Savee' showed 10-16%, and 'Trad Sri Thong' showed 100% TS and IB symptom...
  54. Konstanta I, Fostira F, Apostolou P, Stratikos E, Kalfakakou D, Pampanos A, et al. Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece. J Hum Genet. 2018;63:1149-1158 pubmed publisher
    b>RAD51D gene's protein product is known to be involved in the DNA repair mechanism by homologous recombination. RAD51D germline mutations have been recently associated with ovarian and breast cancer (OC and BC, respectively) predisposition...
  55. Stafford J, Dyson G, Levin N, Chaudhry S, Rosati R, Kalpage H, et al. Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability. PLoS ONE. 2017;12:e0178450 pubmed publisher
    ..five pathogenic variants in our sample, four of which are in two genes featured on current multi-gene panels; (RAD51D, ATM)...
  56. Tung N, Lin N, Kidd J, Allen B, Singh N, Wenstrup R, et al. Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer. J Clin Oncol. 2016;34:1460-8 pubmed publisher
    ..genes including CHEK2 (n = 10), ATM (n = 4), BRIP1 (n = 4), and one each in PALB2, PTEN, NBN, RAD51C, RAD51D, MSH6, and PMS2. Whereas young age (P < .01), Ashkenazi Jewish ancestry (P < ...
  57. Fadic X, Placencia F, Dominguez A, Cereceda Balic F. Tradescantia as a biomonitor for pesticide genotoxicity evaluation of iprodione, carbaryl, dimethoate and 4,4'-DDE. Sci Total Environ. 2017;575:146-151 pubmed publisher
    ..In this paper, the sensibility of both the Tradescantia micronucleus bioassay (Trad-MCN) and the Tradescantia stamen hair bioassay (Trad-SH) were studied for carbaryl, dimethoate and iprodione, ..
  58. Wardell C, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, et al. Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. J Hepatol. 2018;68:959-969 pubmed publisher
    ..Deleterious germline mutations of cancer-predisposing genes such as BRCA1, BRCA2, RAD51D, MLH1, or MSH2 were detected in 11% (16/146) of BTC patients...
  59. Casu B, Mary C, Sverzhinsky A, Fouillen A, Nanci A, Baron C. VirB8 homolog TraE from plasmid pKM101 forms a hexameric ring structure and interacts with the VirB6 homolog TraD. Proc Natl Acad Sci U S A. 2018;115:5950-5955 pubmed publisher
    ..We also overproduced and purified the VirB6 homolog TraD and show by cross-linking, SEC, and EM that it binds to TraE...
  60. Bernards S, Norquist B, Harrell M, Agnew K, Lee M, Walsh T, et al. Genetic characterization of early onset ovarian carcinoma. Gynecol Oncol. 2016;140:221-5 pubmed publisher
    ..evaluated 11 genes associated with ovarian carcinoma (BARD1, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51D, and RAD51C) and additional candidate genes in DNA repair (ATM, BAP1, CHEK2, MRE11A, NBN, PTEN, TP53)...
  61. Qin Q, Yang D, Xie H, Zhang L, Wang C. Ultrasound guidance improves the success rate of axillary plexus block: a meta-analysis. Braz J Anesthesiol. 2016;66:115-9 pubmed publisher
    ..US guidance (US group) and the controlled group included 885 patients (246 patients using traditional approach (TRAD) and 639 patients using nerve stimulation (NS))...
  62. Ma H, Song T, Wang T, Wang S. Influence of Human p53 on Plant Development. PLoS ONE. 2016;11:e0162840 pubmed publisher
    ..b>RAD51D is a recombinase in homologous recombination and functions downstream of SNI1 in plants...
  63. Ugwa E, Otolorin E, Kabue M, Ishola G, Evans C, Oniyire A, et al. Simulation-based low-dose, high-frequency plus mobile mentoring versus traditional group-based training approaches on day of birth care among maternal and newborn healthcare providers in Ebonyi and Kogi States, Nigeria; a randomized controlled trial. BMC Health Serv Res. 2018;18:630 pubmed publisher
    ..LDHF) plus mentoring approach compared to the commonly employed offsite traditional group-based training (TRAD)...
  64. Yimit A, Kim T, Anand R, Meister S, Ou J, Haber J, et al. MTE1 Functions with MPH1 in Double-Strand Break Repair. Genetics. 2016;203:147-57 pubmed publisher
    ..We identified 29 proteins that colocalize with recombination repair protein Rad52 in response to DNA damage...
  65. Simonyan A, Gabrielyan B, Minasyan S, Hovhannisyan G, Aroutiounian R. Genotoxicity of Water Contaminants from the Basin of Lake Sevan, Armenia Evaluated by the Comet Assay in Gibel Carp (Carassius auratus gibelio) and Tradescantia Bioassays. Bull Environ Contam Toxicol. 2016;96:309-13 pubmed publisher
    ..technique (comet assay) in erythrocytes of gibel carp (Carassius auratus gibelio), Tradescantia micronucleus (Trad-MCN) and Tradescantia stamen hair mutation (Trad-SHM) assays...
  66. Avalyan R, Aghajanyan E, Khosrovyan A, Atoyants A, Simonyan A, Aroutiounian R. Assessment of mutagenicity of water from Lake Sevan, Armenia with application of Tradescantia (clone 02). Mutat Res. 2017;800-802:8-13 pubmed publisher
    ..The genotoxicity of water samples collected from different parts of Lake Sevan were assessed by means of Trad-SHM (stamen hair mutation) assay using Tradescantia (clone 02)...
  67. Tian B, Hou K, Zhou H. The Traffic Adaptive Data Dissemination (TrAD) Protocol for both Urban and Highway Scenarios. Sensors (Basel). 2016;16: pubmed publisher
    ..In this paper, an infrastructure-less Traffic Adaptive data Dissemination (TrAD) protocol which takes into account road traffic and network traffic status for both highway and urban scenarios ..
  68. Sánchez Bermúdez A, Sarabia Meseguer M, García Aliaga Á, Marín Vera M, Macías Cerrolaza J, Henaréjos P, et al. Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain). Eur J Med Genet. 2018;61:355-361 pubmed publisher
    RAD51C and RAD51D have been defined as susceptibility genes for hereditary breast and ovarian cancer syndrome in several studies. In the present study, a mutation analysis of these genes was performed on non BRCA1/2 families...
  69. Schaetzel S, Dirks R, Davis J. Comparison of outcomes of patients with acute appendicitis between an acute care surgery model and traditional call coverage model in the same community. Am J Surg. 2016;212:1083-1089 pubmed publisher
    This study compared outcomes, patient flow, and cost between an acute care surgery (ACS) and traditional call model (TRAD) for acute appendicitis in the same community and time period...
  70. Weakley J, Till K, Read D, Roe G, Darrall Jones J, Phibbs P, et al. The effects of traditional, superset, and tri-set resistance training structures on perceived intensity and physiological responses. Eur J Appl Physiol. 2017;117:1877-1889 pubmed publisher
    Investigate the acute and short-term (i.e., 24 h) effects of traditional (TRAD), superset (SS), and tri-set (TRI) resistance training protocols on perceptions of intensity and physiological responses...
  71. Haile T, Mišík M, Grummt T, Halh A, Pichler C, Knasmueller S, et al. Cytotoxic and genotoxic activities of waters and sediments from highway and parking lot runoffs. Water Sci Technol. 2016;73:2772-80 pubmed publisher
    ..urban highway runoff was tested in the Salmonella/microsome assays with Salmonella typhimurium, micronucleus assay (Trad-MN) with plants and with human-derived liver cells (HepG2), or comet assay with HepG2...
  72. Hegedus E, Hardesty K, Sunderland K, Hegedus R, Smoliga J. A randomized trial of traditional and golf-specific resistance training in amateur female golfers: Benefits beyond golf performance. Phys Ther Sport. 2016;22:41-53 pubmed publisher
    Compare golf-specific resistance training (GSRT) with traditional resistance training (TRAD) with regard to golf performance and other outcome measures. Randomized controlled study. Outpatient gym...
  73. Hull J, Elizondo Riojas G, Bishop W, Voneida Reyna Y. Thermal Resistance Anastomosis Device for the Percutaneous Creation of Arteriovenous Fistulae for Hemodialysis. J Vasc Interv Radiol. 2017;28:380-387 pubmed publisher
    ..the safety and efficacy of arteriovenous fistula (AVF) creation with a thermal resistance anastomosis device (TRAD)...
  74. Angleri V, Ugrinowitsch C, Libardi C. Crescent pyramid and drop-set systems do not promote greater strength gains, muscle hypertrophy, and changes on muscle architecture compared with traditional resistance training in well-trained men. Eur J Appl Physiol. 2017;117:359-369 pubmed publisher
    ..was to compare the effects of crescent pyramid (CP) and drop-set (DS) systems with traditional resistance training (TRAD) with equalized total training volume (TTV) on maximum dynamic strength (1-RM), muscle cross-sectional area (CSA), ..
  75. Balasubramanian I, Creavin B, Winter D. Impact of an acute surgical unit in appendicectomy outcomes: A systematic review and meta-analysis. Int J Surg. 2018;50:114-120 pubmed publisher
    ..A comprehensive literature search of PubMed, Embase and Scopus for published studies comparing ASU and traditional (TRAD) model on appendectomy outcomes was performed...
  76. Heng J, Zhang F, Guo X, Tang L, Peng L, Luo X, et al. Integrated analysis of promoter methylation and expression of telomere related genes in breast cancer. Oncotarget. 2017;8:25442-25454 pubmed publisher
    ..A total of 4 genes (RAD50, RTEL, TERC and TRF1) showed significant hyper-methylation in breast tumor tissues. RAD51D showed significant methylation difference among the four breast cancer subtypes...
  77. Pelttari L, Kinnunen L, Kiiski J, Khan S, Blomqvist C, Aittomäki K, et al. Screening of HELQ in breast and ovarian cancer families. Fam Cancer. 2016;15:19-23 pubmed publisher
    ..HELQ interacts with the RAD51 paralog complex BCDX2. Two components of the complex, RAD51C and RAD51D, increase the risk of ovarian cancer especially, and the other two, RAD51B and XRCC2 have been associated with ..
  78. Bendjeddou M, Bouslama Z, Amr Z, BaniHani R. Infestation and seasonal activity of Ixodes vespertilionis Koch, 1844 (Acari: Ixodidae) on the Maghreb mouse-eared bat, Myotis punicus Felten, 1977, in northeastern Algeria. J Vector Ecol. 2016;41:110-3 pubmed publisher
    Infestation of Ixodes vespertilionis Koch, 1844 on Myotis punicus Felten, 1977 from two sites (Trios Tunnel and Sidi Trad cave) in northeastern Algeria was studied. An overall infestation of 41...
  79. Amato Lourenço L, Lobo D, Guimarães E, Moreira T, Carvalho Oliveira R, Saiki M, et al. Biomonitoring of genotoxic effects and elemental accumulation derived from air pollution in community urban gardens. Sci Total Environ. 2017;575:1438-1444 pubmed publisher
    ..cv. "Purpurea" Boom (hereafter, Trad-MCN) as a short-term indicator of genotoxic response and tree barks to quantify the accumulation of traffic-related ..
  80. Qin Q, Yang D, Xie H, Zhang L, Wang C. [Ultrasound guidance improves the success rate of axillary plexus block: a meta-analysis]. Rev Bras Anestesiol. 2016;66:115-9 pubmed publisher
    ..US guidance (US group) and the controlled group included 885 patients (246 patients using traditional approach (TRAD) and 639 patients using nerve stimulation (NS))...
  81. Schayek H, Korach H, Laitman Y, Bernstein Molho R, Friedman E. Mutational analysis of candidate genes in Israeli male breast cancer cases. Breast Cancer Res Treat. 2018;170:399-404 pubmed publisher
    ..1100delC, p.S428F, p.I157T), and single mutations in the FANCM (c.5791C>T), and RAD51D (c.556C>T) genes, by direct sequencing. The ethics committee approved the study...
  82. Sonesson A, Ødegård J. Mating structures for genomic selection breeding programs in aquaculture. Genet Sel Evol. 2016;48:46 pubmed publisher
    ..between families when selection is on traditional best linear unbiased prediction (BLUP) estimated breeding values (TRAD-EBV)...
  83. Lastayo P, Marcus R, DIBBLE L, Wong B, Pepper G. Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program. BMC Geriatr. 2017;17:149 pubmed publisher
    ..to compare the effects of resistance exercise via negative, eccentrically-induced, work (RENEW) versus traditional (TRAD) resistance exercise on mobility, balance confidence, muscle power and cross sectional area, as well as the number ..
  84. Cartwright R, Dunn A, Simpson P, Tambini C, Thacker J. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. Nucleic Acids Res. 1998;26:1653-9 pubmed
    ..The new genes (R51H2 and R51H3) were mapped to human chromosomes 14q23-24 and 17q1.2, respectively...
  85. Song H, Dicks E, Ramus S, Tyrer J, Intermaggio M, HAYWARD J, et al. Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. J Clin Oncol. 2015;33:2901-7 pubmed publisher
    The aim of this study was to estimate the contribution of deleterious mutations in the RAD51B, RAD51C, and RAD51D genes to invasive epithelial ovarian cancer (EOC) in the population and in a screening trial of individuals at high risk of ..
  86. Yard B, Reilly N, Bedenbaugh M, Pittman D. RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity. DNA Repair (Amst). 2016;42:82-93 pubmed publisher
    ..b>RAD51D, the fourth member of the family, is a known ovarian cancer susceptibility gene and required for the repair of ..
  87. Byers H, Wallis Y, van Veen E, Lalloo F, Reay K, Smith P, et al. Sensitivity of BRCA1/2 testing in high-risk breast/ovarian/male breast cancer families: little contribution of comprehensive RNA/NGS panel testing. Eur J Hum Genet. 2016;24:1591-1597 pubmed publisher
    ..Panel testing in 42 samples identified a known RAD51D variant, a high-risk ATM variant in another breast ovary family and a truncating CHEK2 mutation...
  88. Rivera B, Di Iorio M, Frankum J, Nadaf J, Fahiminiya S, Arcand S, et al. Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma. Cancer Res. 2017;77:4517-4529 pubmed publisher
    b>RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating variant carriers have an increased risk for ovarian cancer...
  89. Pittman D, Weinberg L, Schimenti J. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. Genomics. 1998;49:103-11 pubmed
    ..Here we describe a new RAD51-related mammalian gene, named Rad51d, identified by searching the EST database with the yeast RAD55 and human RAD51B/REC2 genes. A full-length 1...
  90. Tarsounas M, Davies A, West S. RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci. 2004;359:87-93 pubmed
    ..to DNA damage is dependent upon BRCA2 and a series of proteins known as the RAD51 paralogues (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), indicating that the components present within foci assemble in a carefully orchestrated and ..
  91. Dowty J, Lose F, Jenkins M, Chang J, Chen X, Beesley J, et al. The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women. Breast Cancer Res Treat. 2008;112:35-9 pubmed
    b>RAD51D is a homolog of the RAD51 protein, which is known to be an important component of the DNA repair pathway. A rare missense variant in the RAD51D gene, E233G (c...
  92. Tambini C, Spink K, Ross C, Hill M, Thacker J. The importance of XRCC2 in RAD51-related DNA damage repair. DNA Repair (Amst). 2010;9:517-25 pubmed publisher
    ..XRCC2 and its partner protein RAD51L3 are found to interact with RAD51 in the 2-hybrid system, and XRCC2 is shown to be important but not essential for ..