Gene Symbol: RAD23B
Description: RAD23 homolog B, nucleotide excision repair protein
Alias: HHR23B, HR23B, P58, UV excision repair protein RAD23 homolog B, RAD23, yeast homolog of, B, XP-C repair complementing complex 58 kDa, XP-C repair complementing protein, XP-C repair-complementing complex 58 kDa protein
Species: human
Products:     RAD23B

Top Publications

  1. Wood R. DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie. 1999;81:39-44 pubmed
    ..excision repair (NER) are the XPA protein, the heterotrimeric RPA protein, the 6 to 9-subunit TFIIH, the XPC-hHR23B complex, the XPG nuclease, and the ERCC1-XPF nuclease...
  2. Batty D, Rapic Otrin V, Levine A, Wood R. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J Mol Biol. 2000;300:275-90 pubmed
    ..group C do not perform NER in the bulk of the genome and are corrected by XPC protein, which forms a complex with hHR23B protein...
  3. Ng J, Vermeulen W, van der Horst G, Bergink S, Sugasawa K, Vrieling H, et al. A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003;17:1630-45 pubmed
    ..global genome nucleotide excision repair (GG-NER) is performed by the xeroderma pigmentosum group C (XPC)/HR23B protein complex...
  4. Glockzin S, Ogi F, Hengstermann A, Scheffner M, Blattner C. Involvement of the DNA repair protein hHR23 in p53 degradation. Mol Cell Biol. 2003;23:8960-9 pubmed
    ..In this model, the Uba domain of hHR23 binds to polyubiquitin chains formed on p53 and protects them from deubiquitylation, while the Ubl domain delivers the polyubiquitylated p53 molecules to the proteasome. ..
  5. Mechanic L, Millikan R, Player J, de Cotret A, Winkel S, Worley K, et al. Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. Carcinogenesis. 2006;27:1377-85 pubmed
    ..and for breast cancer and nine non-synonymous coding polymorphisms in six NER genes (XPD codons 312 and 751, RAD23B codon 249, XPG codon 1104, XPC codon 939, XPF codons 415 and 662, and ERCC6 codons 1213 and 1230)...
  6. Huang W, Berndt S, Kang D, Chatterjee N, Chanock S, Yeager M, et al. Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev. 2006;15:306-11 pubmed
    ..was extracted from blood samples and 15 common nonsynonymous SNPs in seven-nucleotide excision repair genes [XPC, RAD23B (hHR23B), CSB (ERCC6), XPD (ERCC2), CCNH, XPF (ERCC4), and XPG (ERCC5)] were genotyped...
  7. Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P, Popanda O. Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Int J Cancer. 2009;125:1431-9 pubmed publisher
    ..with 14 single nucleotide polymorphisms (SNPs) in 8 NER genes (XPC, XPA, ERCC1, ERCC2, ERCC4, ERCC5, ERCC6 and RAD23B) was analyzed with respect to smoking and alcohol exposure...
  8. Fong Y, Inouye C, Yamaguchi T, Cattoglio C, Grubisic I, Tjian R. A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells. Cell. 2011;147:120-31 pubmed publisher
    ..This study identifies a transcriptional coactivator with diversified functions in maintaining ES cell pluripotency and safeguarding genome integrity. ..
  9. Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, et al. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 1994;13:1831-43 pubmed
    ..All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer. ..

More Information

Publications114 found, 100 shown here

  1. van der Spek P, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, et al. XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. Nucleic Acids Res. 1996;24:2551-9 pubmed
    ..The XPC protein is complexed with HHR23B, one of the two human homologs of the yeast NER protein, RAD23 (Masutani at al. (1994) EMBO J. 8, 1831-1843)...
  2. Withers Ward E, Jowett J, Stewart S, Xie Y, Garfinkel A, Shibagaki Y, et al. Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. J Virol. 1997;71:9732-42 pubmed
  3. Sugasawa K, Ng J, Masutani C, Iwai S, van der Spek P, Eker A, et al. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell. 1998;2:223-32 pubmed
    The XPC-HR23B complex is specifically involved in global genome but not transcription-coupled nucleotide excision repair (NER). Its function is unknown...
  4. Yokoi M, Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka F. The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA. J Biol Chem. 2000;275:9870-5 pubmed
    The xeroderma pigmentosum group C protein complex XPC-HR23B was first isolated as a factor that complemented nucleotide excision repair defects of XP-C cell extracts in vitro...
  5. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
    ..originally thought to contain the XP group C responsible gene product (XPC) and the human homologue of Rad23 B (HR23B). Here, we show that centrin 2/caltractin 1 (CEN2) is also a component of the XPC repair complex...
  6. Shen M, Berndt S, Rothman N, DeMarini D, Mumford J, He X, et al. Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China. Int J Cancer. 2005;116:768-73 pubmed
    ..polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei...
  7. Thoma B, Wakasugi M, Christensen J, Reddy M, Vasquez K. Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks. Nucleic Acids Res. 2005;33:2993-3001 pubmed
    ..ICL to a target DNA substrate to determine whether the human global genome NER damage recognition complex, XPC-hHR23B, recognizes this lesion...
  8. Hsieh H, Hsieh Y, Huang Y, Shen F, Tsai H, Tsai J, et al. HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair. Biochem Biophys Res Commun. 2005;335:181-7 pubmed
    HHR23A and hHR23B are the human homologs of Saccharomyces cerevisiae Rad23. hHR23B is associated with the nucleotide excision repair (NER) factor xeroderma pigmentosum C (XPC) protein and is required for global genome repair...
  9. Katiyar S, Lennarz W. Studies on the intracellular localization of hHR23B. Biochem Biophys Res Commun. 2005;337:1296-300 pubmed
    ..Two human homologs of yeast Rad23, hHR23A and hHR23B, exhibit high sequence homology with yRad23 and also have been shown to be involved in DNA repair and proteasome-..
  10. Garcia Closas M, Malats N, Real F, Welch R, Kogevinas M, Chatterjee N, et al. Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:536-42 pubmed
    ..NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6)...
  11. Chen M, Kamat A, Huang M, Grossman H, Dinney C, Lerner S, et al. High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. Carcinogenesis. 2007;28:2160-5 pubmed
    ..classification and regression tree analysis, we observed gene-gene interactions among CCNH V270A, ERCC6 M1097V and RAD23B A249V in ever smokers: smokers with the variant alleles at these three loci had an almost 30-fold increased risk ..
  12. Zhang M, Huang W, Andreotti G, Gao Y, Rashid A, Chen J, et al. Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. Cancer Epidemiol Biomarkers Prev. 2008;17:2123-7 pubmed publisher
    ..population were genotyped for putative functional single nucleotide polymorphisms in four DNA repair genes (MGMT, RAD23B, CCNH, and XRCC3)...
  13. Chang J, Wrensch M, Hansen H, Sison J, Aldrich M, Quesenberry C, et al. Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Int J Cancer. 2008;123:2095-104 pubmed publisher
    ..We examine variants in 6 NER genes (ERCC2, ERCC4, ERCC5, LIG1, RAD23B and XPC) in association with primary lung cancer risk among 113 Latino and 255 African American subjects newly ..
  14. Pan J, Lin J, Izzo J, Liu Y, Xing J, Huang M, et al. Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway. Carcinogenesis. 2009;30:785-92 pubmed publisher
    ..Further, the CT genotype of the RAD23B Ala249Val was associated with increased esophageal cancer risk (OR = 1.44; 95% CI = 1.05-1...
  15. Sugasawa K, Akagi J, Nishi R, Iwai S, Hanaoka F. Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell. 2009;36:642-53 pubmed publisher
    ..Our results dissect the intricate molecular mechanism of NER and provide insights into a strategy for mammalian cells to survey large genomes to detect DNA damage. ..
  16. Tomoda T, Nouso K, Sakai A, Ouchida M, Kobayashi S, Miyahara K, et al. Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. J Gastroenterol Hepatol. 2012;27:797-804 pubmed publisher
    ..29-1.76). These included novel SNPs for hepatocarcinogenesis with HCV CCND2 rs1049606, RAD23B rs1805329, CEP164 rs573455, and GRP78rs430397 in addition to the known SNPs MDM2 rs2279744 and ALDH2 rs671...
  17. Sannerud R, Marie M, Nizak C, Dale H, Pernet Gallay K, Perez F, et al. Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery. Mol Biol Cell. 2006;17:1514-26 pubmed
    ..involves expansion of the IC and movement of Rab1-containing tubules to the growth cones of the neurites, whereas p58- and COPI-positive IC elements, like rough ER and Golgi, remain in the cell body...
  18. Merlot A, Shafie N, Yu Y, Richardson V, Jansson P, Sahni S, et al. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Biochem Pharmacol. 2016;109:27-47 pubmed publisher
    ..g., XBP1s and p58(IPK)); (4) increased cleavage of the transcription factor, ATF6, which enhances expression of its downstream ..
  19. Mu H, Geacintov N, Broyde S, Yeo J, SCHARER O. Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair. DNA Repair (Amst). 2018;71:33-42 pubmed publisher
    ..recognition in NER is the sensing of lesion-induced thermodynamic and structural alterations of DNA by the XPC-RAD23B protein and the verification of the damage by the transcription/repair factor TFIIH...
  20. Neifar S, Hlima H, Mhiri S, Mezghani M, Bouacem K, Ibrahim A, et al. A novel thermostable and efficient Class II glucose isomerase from the thermophilic Caldicoprobacter algeriensis: Biochemical characterization, molecular investigation, and application in High Fructose Syrup production. Int J Biol Macromol. 2019;129:31-40 pubmed publisher
    ..Moreover, a serine at position 56 near to P58 could establish hydrogen bond strengthening the dimer attachment...
  21. Nozari M, Shabani M, Farhangi A, Mazhari S, Atapour N. Sex-specific restoration of MK-801-induced sensorimotor gating deficit by environmental enrichment. Neuroscience. 2015;299:28-34 pubmed publisher
    ..EE was provided from birth up to the time of experiments on P28-30 or P58-60. PPI data were collected at three prepulse intensities and then averaged to yield global PPI...
  22. Khan N, Song C, Jennings B, Estes A, Fang X, Bonventre J, et al. Cytosolic phospholipase A2α is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology. Hypertension. 2015;65:784-92 pubmed publisher
    ..and CD3(+) T lymphocytes, cardiovascular oxidative stress, expression of endoplasmic reticulum stress markers p58(IPK), and CHOP in cPLA2α(+/+) but not cPLA2α(-/-) mice...
  23. Falkenberg K, Newbold A, Gould C, Luu J, Trapani J, Matthews G, et al. A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity. Cell Death Differ. 2016;23:1209-18 pubmed publisher
    ..transducer and activator of transcription) activation, overexpression of prosurvival Bcl-2 proteins and loss of HR23B have been identified as potential biomarkers of HDACi resistance; however, none have yet been used to aid the ..
  24. Beauvais G, Bode N, Watson J, Wen H, Glenn K, Kawano H, et al. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. J Neurosci. 2016;36:10245-10256 pubmed
    ..To test this hypothesis, we crossed DYT1 knock-in with p58(IPK)-null mice...
  25. Fujiwara K, Tenno T, Sugasawa K, Jee J, Ohki I, Kojima C, et al. Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B. J Biol Chem. 2004;279:4760-7 pubmed
    ..Of them, HR23B regulates the proteasomal targeting of ubiquitinated substrates, DNA repair factors, and other proteins...
  26. Tao J, Petrova K, Ron D, Sha B. Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR. J Mol Biol. 2010;397:1307-15 pubmed publisher
    b>P58(IPK) might function as an endoplasmic reticulum molecular chaperone to maintain protein folding homeostasis during unfolded protein responses...
  27. Baranovskiy A, Zhang Y, Suwa Y, Babayeva N, Gu J, Pavlov Y, et al. Crystal structure of the human primase. J Biol Chem. 2015;290:5635-46 pubmed publisher
    ..The presence of a long linker between the N- and C-terminal domains of p58 provides the structural basis for the bulk of enzyme's conformational flexibility...
  28. Cattoglio C, Zhang E, Grubisic I, Chiba K, Fong Y, Tjian R. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A. 2015;112:E2317-26 pubmed publisher
    ..We recently identified the DNA-repair complex xeroderma pigmentosum C (XPC)-RAD23B-CETN2 as a stem cell coactivator (SCC) required for OCT4/SOX2 transcriptional activation...
  29. Nakayasu E, Ansong C, Brown J, Yang F, Lopez Ferrer D, Qian W, et al. Evaluation of selected binding domains for the analysis of ubiquitinated proteomes. J Am Soc Mass Spectrom. 2013;24:1214-23 pubmed publisher
    ..This approach is especially promising for the analysis of tissues or cells resistant to transfection, of which the overexpression of tagged ubiquitin is a major hurdle. ..
  30. Fomina E, Pestryakov P, Maltseva E, Petruseva I, Kretov D, Ovchinnikov L, et al. Y-box binding protein 1 (YB-1) promotes detection of DNA bulky lesions by XPC-HR23B factor. Biochemistry (Mosc). 2015;80:219-27 pubmed publisher
    ..g. cisplatin. One of the major NER components is XPC-HR23B, the key factor during the damage recognition step of repair...
  31. Zhang Y, Gendron T, Grima J, Sasaguri H, Jansen West K, Xu Y, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nat Neurosci. 2016;19:668-677 pubmed publisher
    ..HR23A and HR23B similarly colocalized to poly(GA) inclusions in C9ORF72 expansion carriers...
  32. Jensen H, Lillenes M, Rabano A, Günther C, Riaz T, Kalayou S, et al. Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood. Neurosci Lett. 2018;672:53-58 pubmed publisher
    ..The mRNA levels of the genes encoding the NER proteins RAD23B, RPA1, ERCC1, PCNA and LIG3 as well as the NER-interacting base excision repair protein MPG in blood and brain ..
  33. Shen Y, Bae I, Park G, Choi H, Lee K, Kim S. MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B. Biomed Pharmacother. 2018;105:362-369 pubmed publisher
    ..Bioinformatics analysis suggested that the DNA repair protein RAD23B was a putative target gene of miR-196b. Overexpression of miR-196b suppressed RAD23B expression in SNU-638 cells...
  34. Guillem V, Cervantes F, Martinez J, Alvarez Larran A, Collado M, Camos M, et al. XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia. Am J Hematol. 2010;85:482-6 pubmed publisher
    ..nucleotide polymorphisms (SNPs) on the nucleotide excision repair (NER) genes (ERCC2-ERCC8, RPA1-RPA3, LIG1, RAD23B, XPA, XPC) was performed in 92 chronic phase CML patients treated with imatinib upfront...
  35. Boriushkin E, Wang J, Li J, Jing G, Seigel G, Zhang S. Identification of p58IPK as a novel neuroprotective factor for retinal neurons. Invest Ophthalmol Vis Sci. 2015;56:1374-86 pubmed publisher
    Endoplasmic reticulum (ER)-resident chaperone protein p58(IPK) plays a vital role in regulation of protein folding and biosynthesis...
  36. Wang W, Tsai T, Chao C, Lai B, Wu Lee Y. Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation. J Virol. 2015;89:11584-602 pubmed publisher
    ..of YB-1 in HCV-infected cells prevented infectious virus production and reduced the ratio of hyperphosphorylated (p58) to hypophosphorylated (p56) forms of NS5A, whereas DDX3 silencing did not affect the ratio of the p58 and p56 ..
  37. Besche H, Haas W, Gygi S, Goldberg A. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry. 2009;48:2538-49 pubmed publisher
    ..This method is based on the affinity of this complex for the ubiquitin-like (UBL) domain of hHR23B and elution with a competing polypeptide containing a ubiquitin-interacting motif...
  38. Roobol A, Roobol J, Bastide A, Knight J, Willis A, Smales C. p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015;465:213-25 pubmed publisher
    ..Thus forced overexpression of cytoplasmic p58 delays eIF2α phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis under endoplasmic ..
  39. Schenk C, Meyrath M, Warnken U, Schnolzer M, Mier W, Harak C, et al. Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation. J Virol. 2018;92: pubmed publisher
    ..by their different apparent molecular weights: a basally phosphorylated (p56) and a hyperphosphorylated (p58) variant...
  40. Dasmahapatra G, Patel H, Friedberg J, Quayle S, Jones S, Grant S. In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells. Mol Cancer Ther. 2014;13:2886-97 pubmed publisher
    ..Combined exposure to carfilzomib and ricolinostat also markedly downregulated the cargo-loading protein HR23B. Moreover, HR23B knockdown significantly increased carfilzomib- and ricolinostat-mediated lethality, suggesting a ..
  41. Wang Q, Li Y, Liu S, Xie W, Cheng J. Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release. World J Gastroenterol. 2018;24:1299-1311 pubmed publisher
    ..The ratio between the p56 and p58 phosphoforms of NS5A was analyzed further...
  42. Gilbert S, Meakin L, Bonnet C, Nowell M, Ladiges W, Morton J, et al. Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice. Front Endocrinol (Lausanne). 2014;5:174 pubmed publisher
    ..We determined whether knockout of the cellular inhibitor of PERK and PKR, P58(IPK) causes joint degeneration in vivo and whether these molecules are activated in human osteoarthritis (OA)...
  43. Lahari T, Lazaro J, Schroeder D. RAD4 and RAD23/HMR Contribute to Arabidopsis UV Tolerance. Genes (Basel). 2017;9: pubmed publisher
    ..analysis to examine the interaction of AtRAD4 with Arabidopsis RAD23 and found that RAD4 interacted with RAD23B as well as with the structurally similar protein HEMERA (HMR)...
  44. Ziani S, Nagy Z, Alekseev S, Soutoglou E, Egly J, Coin F. Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin. J Cell Biol. 2014;206:589-98 pubmed publisher
    In nucleotide excision repair (NER), damage recognition by XPC-hHR23b is described as a critical step in the formation of the preincision complex (PInC) further composed of TFIIH, XPA, RPA, XPG, and ERCC1-XPF...
  45. Li L, Lu X, Peterson C, Legerski R. XPC interacts with both HHR23B and HHR23A in vivo. Mutat Res. 1997;383:197-203 pubmed
    XP group C protein (XPC) and a human homologue of RAD23, HHR23B, have previously been shown to copurify in a tightly associated complex...
  46. Guo H, Bassig B, Lan Q, Zhu Y, Zhang Y, Holford T, et al. Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma. Cancer Causes Control. 2014;25:1261-70 pubmed publisher
    ..07(1.10-3.90)] and rs1056503 TT [OR(95% CI) 2.17(1.16-4.07)], ERCC1 rs3212961 CC [OR(95% CI) 1.93(1.00-3.72)], RAD23B rs1805329 CC [OR(95% CI) 2.28(1.12-4...
  47. Tong S, Liu J, Zhang C. Platelet-rich plasma inhibits inflammatory factors and represses rheumatoid fibroblast-like synoviocytes in rheumatoid arthritis. Clin Exp Med. 2017;17:441-449 pubmed publisher
    ..05). The mRNA and protein levels of AKT1, PI3K (p58) and nuclear factor ? beta were elevated by LPS and then suppressed by PRP (P < 0.01)...
  48. Chen L, Madura K. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. FEBS Lett. 2006;580:3401-8 pubmed
    ..Although human Rad23 proteins (hHR23A and hHR23B) have redundant roles in DNA repair, we determined they formed distinct interactions with proteasomes and ..
  49. Huang C, Wang J, Jing G, Li J, Jin C, Yu Q, et al. Erp29 Attenuates Cigarette Smoke Extract-Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015;56:6196-207 pubmed publisher
    ..Overexpression of ERp29 increased the levels of GRP78, p58(IPK), and Nrf-2, while reducing p-eIF2α and C/EBP homologous protein (CHOP), and protected RPE cells from CSE-..
  50. Wei S, Yu Y, Weiss R, Felder R. Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats. Hypertension. 2016;67:229-36 pubmed publisher
    ..protein 78, activating transcription factor 6, activating transcription factor 4, X-box binding protein 1, P58(IPK), and C/EBP homologous protein) in subfornical organ and paraventricular nucleus, which were attenuated by a 4-..
  51. Bhat A, Qin Z, Wang G, Chen W, Xiao W. Rev7, the regulatory subunit of Polζ, undergoes UV-induced and Cul4-dependent degradation. FEBS J. 2017;284:1790-1803 pubmed publisher
    ..We also show that the nucleotide excision repair (NER) pathway protein HR23B physically interacts and colocalizes with Rev7 in the nuclear foci after UV irradiation and protects Rev7 from ..
  52. Walters K, Kleijnen M, Goh A, Wagner G, Howley P. Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry. 2002;41:1767-77 pubmed
    ..This study provides structural insights into protein recognition by the proteasome, and illustrates how the protein surface of a commonly utilized fold has highly evolved for various biological roles. ..
  53. Huang X, Wang H, Xu M, Lu L, Xu Z, Li J, et al. Expression of a novel RAD23B mRNA splice variant in the human testis. J Androl. 2004;25:363-8 pubmed
    A gene coding a novel human RAD23B protein named RAD23-like protein B, presumably involved in spermatogenesis, was identified and characterized using a complementary DNA (cDNA) microarray. In the human testis, its expression was 2...
  54. Lin J, Swan G, Shields P, Benowitz N, Gu J, Amos C, et al. Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. Cancer Epidemiol Biomarkers Prev. 2007;16:2065-71 pubmed
    ..nucleotide polymorphisms examined, we found that BPDE sensitivity was modified by individual polymorphisms in XPC, RAD23B, and XPA genes. Specific haplotypes and diplotypes of XPC also modified BPDE sensitivity profiles...
  55. You X, Guo W, Wang L, Hou Y, Zhang H, Pan Y, et al. Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs. Cell Signal. 2017;36:108-116 pubmed publisher
    The RAD23B-XPC complex in the nucleus plays a key role in the initial damage recognition during global genome nucleotide excision repair (NER)...
  56. Katiyar S, Li G, Lennarz W. A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc Natl Acad Sci U S A. 2004;101:13774-9 pubmed
    ..Immunofluorescence studies revealed that hPNGase, hHR23B, and hS4 are present in close proximity to the endoplasmic reticulum (ER) when calnexin was used as an ER marker ..
  57. Li X, Demartino G. Variably modulated gating of the 26S proteasome by ATP and polyubiquitin. Biochem J. 2009;421:397-404 pubmed publisher
    ..Our results suggest that modulated gating of the proteasome may be an important element of the mechanism of proteolysis of polyubiquitylated proteins. ..
  58. Fletcher O, Johnson N, Orr N, Hosking F, Gibson L, Walker K, et al. Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. J Natl Cancer Inst. 2011;103:425-35 pubmed publisher
    ..maps to a gene desert, the nearest genes being Kruppel-like factor 4 (KLF4, 636 kb centromeric), RAD23 homolog B (RAD23B, 794 kb centromeric), and actin-like 7A (ACTL7A, 736 kb telomeric)...
  59. Maltseva E, Rechkunova N, Sukhanova M, Lavrik O. Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation. J Biol Chem. 2015;290:21811-20 pubmed publisher
    ..The XPC-RAD23B complex is one of the key factors of nucleotide excision repair participating in the primary DNA damage ..
  60. Zajkowska J, Lelental N, Kulakowska A, Mroczko B, Pancewicz S, Bucki R, et al. Application of multiplexing technology to the analysis of the intrathecally released immunoglobulins against B. burgdorferi antigens in neuroborreliosis. Immunol Lett. 2015;168:58-63 pubmed publisher
    ..01). Twenty-one of 27 NB patients had at least one positive (>1.5) IgG-ASI against either VlsE, p100, p58, p39, p18, or OspC, and none of these patients showed positive OspA-IgG-ASI...
  61. Shafirovich V, Kropachev K, Anderson T, Liu Z, Kolbanovskiy M, Martin B, et al. Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA. J Biol Chem. 2016;291:5309-19 pubmed publisher
    ..However, normal NER activity appeared when the XPC(-/-) cell extracts were complemented with XPC-RAD23B proteins. The Sp and Gh lesions are excellent substrates of both BER and NER...
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    ..Interaction of NER protein XPC-RAD23B providing primary damage recognition with DNA duplexes containing a B[a]P-derived residue linked to the exocyclic ..
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    ..probe III) have increased (as compared to unmodified DNA, umDNA) structure-dependent affinity for XPC-HR23B (Kdum > KdI > KdII ? KdIII) and differentially crosslink to XPC and proteins of NER-competent extracts...
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    ..The purified recombinant protein and antibodies would be useful reagents to study the biochemistry of nucleotide excision repair in plants. ..
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    Human cells contain two homologs of the yeast RAD23 protein, hHR23A and hHR23B, which participate in the DNA repair process...
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    ..The C-terminal portion of XPC (residues 492-940; XPC-C) has critical interactions with DNA, RAD23B, CETN2, and TFIIH, whereas functional roles have not yet been assigned to the N-terminal portion (residues 1-491; ..
  89. Roche Y, Zhang D, Segers Nolten G, Vermeulen W, Wyman C, Sugasawa K, et al. Fluorescence correlation spectroscopy of the binding of nucleotide excision repair protein XPC-hHr23B with DNA substrates. J Fluoresc. 2008;18:987-95 pubmed publisher
    The interaction of the nucleotide excision repair (NER) protein dimeric complex XPC-hHR23B, which is implicated in the DNA damage recognition step, with three Cy3...
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  91. Petruseva I, Tikhanovich I, Maltseva E, Safronov I, Lavrik O. Photoactivated DNA analogs of substrates of the nucleotide excision repair system and their interaction with proteins of NER-competent HeLa cell extract. Biochemistry (Mosc). 2009;74:491-501 pubmed
    ..Mutual influence of simultaneous presence of extract proteins and recombinant NER protein factors XPC-HR23B, XPA, and RPA on interaction with the model DNA was analyzed...
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    ..Twelve genetic polymorphisms in NER genes XPA, XPC, ERCC1, ERCC2, ERCC5, ERCC6 and RAD23B were assessed by multiplex PCR with single base extension...