RACK1

Summary

Gene Symbol: RACK1
Description: receptor for activated C kinase 1
Alias: GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21, receptor of activated protein C kinase 1, cell proliferation-inducing gene 21 protein, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, guanine nucleotide binding protein beta polypeptide 2-like 1, guanine nucleotide-binding protein subunit beta-2-like 1, guanine nucleotide-binding protein subunit beta-like protein 12.3, human lung cancer oncogene 7 protein, lung cancer oncogene 7, proliferation-inducing gene 21, protein homologous to chicken B complex protein, guanine nucleotide binding, receptor of activated protein kinase C 1, small ribosomal subunit protein RACK1
Species: human
Products:     RACK1

Top Publications

  1. Disatnik M, Hernandez Sotomayor S, Jones G, Carpenter G, Mochly Rosen D. Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C. Proc Natl Acad Sci U S A. 1994;91:559-63 pubmed
  2. Nery F, Rui E, Kuniyoshi T, Kobarg J. Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. Biochem Biophys Res Commun. 2006;341:847-55 pubmed
    Ki-1/57 is a cytoplasmic and nuclear phospho-protein of 57 kDa and interacts with the adaptor protein RACK1, the transcription factor MEF2C, and the chromatin remodeling factor CHD3, suggesting that it might be involved in the regulation ..
  3. Yarwood S, Steele M, Scotland G, Houslay M, Bolger G. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. J Biol Chem. 1999;274:14909-17 pubmed
    The WD-repeat protein receptor for activated C-kinase (RACK1) was identified by its interaction with the cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4D5 in a yeast two-hybrid screen...
  4. Bolger G, Baillie G, Li X, Lynch M, Herzyk P, Mohamed A, et al. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J. 2006;398:23-36 pubmed
    ..Two-hybrid and co-immunoprecipitation analyses showed that RACK1 and beta-arrestin interact with PDE4D5 in a mutually exclusive manner...
  5. Kiely P, O Gorman D, Luong K, Ron D, O Connor R. Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol. 2006;26:4041-51 pubmed
    The WD repeat scaffolding protein RACK1 can mediate integration of the insulin-like growth factor I receptor (IGF-IR) and integrin signaling in transformed cells...
  6. Jannot G, Bajan S, Giguère N, Bouasker S, Banville I, Piquet S, et al. The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep. 2011;12:581-6 pubmed publisher
    ..and the ribosome by showing that a constituent of the eukaryotic 40S subunit, receptor for activated C-kinase (RACK1), is important for miRNA-mediated gene regulation in animals...
  7. Angenstein F, Evans A, Settlage R, Moran S, Ling S, Klintsova A, et al. A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci. 2002;22:8827-37 pubmed
    ..Here we report that a receptor for activated C kinase, RACK1, is a component of messenger ribonucleoprotein (mRNP) complexes...
  8. Ceci M, Gaviraghi C, Gorrini C, Sala L, Offenhauser N, Marchisio P, et al. Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly. Nature. 2003;426:579-84 pubmed
    ..In the cytoplasm, eIF6 is bound to free 60S but not to 80S. Furthermore, eIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C (PKC)...
  9. Besson A, Wilson T, Yong V. The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. J Biol Chem. 2002;277:22073-84 pubmed
    ..We provide novel evidence that the scaffolding protein RACK1 mediates the interaction between integrin beta chain and activated PKCepsilon...

More Information

Publications78

  1. Hermanto U, Zong C, Li W, Wang L. RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002;22:2345-65 pubmed
    ..We identified RACK1, a WD repeat family member and a Gbeta homologue, and demonstrated that RACK1 interacts with the IGF-IR but not ..
  2. Mourton T, Hellberg C, Burden Gulley S, Hinman J, Rhee A, Brady Kalnay S. The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts. J Biol Chem. 2001;276:14896-901 pubmed
    ..Sequencing of two positive clones identified the scaffolding protein RACK1 (receptor for activated protein C kinase) as a PTPmu interacting protein...
  3. Lopez Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang L, RONAI Z. RACK1 mediates activation of JNK by protein kinase C [corrected]. Mol Cell. 2005;19:309-20 pubmed
    ..Here, we demonstrate that the receptor for activated C kinase 1 (RACK1) serves as an adaptor for PKC-mediated JNK activation...
  4. Nilsson J, Sengupta J, Frank J, Nissen P. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 2004;5:1137-41 pubmed
    The receptor for activated C-kinase (RACK1) is a scaffold protein that is able to interact simultaneously with several signalling molecules. It binds to protein kinases and membrane-bound receptors in a regulated fashion...
  5. Kiely P, Baillie G, Lynch M, Houslay M, O Connor R. Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. J Biol Chem. 2008;283:22952-61 pubmed publisher
    ..regulates a mutually exclusive interaction of PP2A and beta1 integrin with the WD repeat scaffolding protein RACK1. This interaction is required for the integration of IGF-I receptor (IGF-IR) and adhesion signaling...
  6. Kiely P, Baillie G, Barrett R, Buckley D, Adams D, Houslay M, et al. Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem. 2009;284:20263-74 pubmed publisher
    ..The scaffolding protein RACK1 (receptor for activated C kinases) integrates insulin-like growth factor I (IGF-I) and integrin signaling, but ..
  7. Kiely P, Leahy M, O Gorman D, O Connor R. RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. J Biol Chem. 2005;280:7624-33 pubmed
    The scaffolding protein receptor for activated C kinase (RACK1) has been proposed to mediate the integration of insulin-like growth factor I receptor (IGF-IR) and adhesion signaling...
  8. Liliental J, Chang D. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. J Biol Chem. 1998;273:2379-83 pubmed
    ..We report an interaction between integrin beta subunit cytoplasmic domain and Rack1, a Trp-Asp (WD) repeat protein that has been shown to bind activated protein kinase C...
  9. Nery F, Passos D, Garcia V, Kobarg J. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. J Biol Chem. 2004;279:11444-55 pubmed
    ..We used the yeast two-hybrid system to find proteins interacting with Ki-1/57 and identified the adaptor protein RACK1 (receptor of activated kinase 1)...
  10. Ron D, Chen C, Caldwell J, Jamieson L, Orr E, Mochly Rosen D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A. 1994;91:839-43 pubmed
    ..In the following study, we describe the cloning of a cDNA encoding a 36-kDa protein (RACK1) that fulfills the criteria for RACKs...
  11. Steele M, McCahill A, Thompson D, MacKenzie C, Isaacs N, Houslay M, et al. Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5. Cell Signal. 2001;13:507-13 pubmed
    ..yeast two-hybrid assay was used to determine the sites on the WD-repeat protein Receptor for Activated C Kinase 1 (RACK1) necessary for it to interact with the cAMP-specific phosphodiesterase isoform PDE4D5...
  12. Nagashio R, Sato Y, Matsumoto T, Kageyama T, Satoh Y, Shinichiro R, et al. Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. Lung Cancer. 2010;69:54-9 pubmed publisher
    ..by modified two-dimensional immunoblotting, and was determined to be the receptor of activated C kinase 1 (RACK1)...
  13. Parent A, Laroche G, Hamelin E, Parent J. RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). Traffic. 2008;9:394-407 pubmed
    ..This screen identified receptor for activated C-kinase 1 (RACK1) as a new TPbeta-interacting protein...
  14. Yi H, Li X, Yi B, Zheng J, Zhu G, Li C, et al. Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis. J Proteome Res. 2010;9:1416-23 pubmed publisher
    ..b>Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in ..
  15. Pass J, Gao J, Jones W, Wead W, Wu X, Zhang J, et al. Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. Am J Physiol Heart Circ Physiol. 2001;281:H2500-10 pubmed
    ..for activated C kinase (RACKs) have been shown to direct PKC signal transduction, the mechanism through which RACK1, a selective PKC beta II RACK, participates in PKC beta II-mediated cardiac hypertrophy and failure remains ..
  16. Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici O. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex. J Immunol. 2003;171:2989-94 pubmed
    ..Finally, we provide evidence that RACK-1 may also serve as a scaffold protein in other cytokine systems such as IL-2, IL-4, and erythropoietin. ..
  17. Geijsen N, Spaargaren M, Raaijmakers J, Lammers J, Koenderman L, Coffer P. Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor. Oncogene. 1999;18:5126-30 pubmed
    ..We found that RACK1, a molecule associating with activated PKC, PLCgamma and Src kinases, associated with the membrane proximal region ..
  18. Mamidipudi V, Zhang J, Lee K, Cartwright C. RACK1 regulates G1/S progression by suppressing Src kinase activity. Mol Cell Biol. 2004;24:6788-98 pubmed
    ..Cancer cells subvert controls at work at this restriction point and remain in cycle. Previously, we showed that RACK1 inhibits the oncogenic Src tyrosine kinase and NIH 3T3 cell growth...
  19. Smith K, Baillie G, Hyde E, Li X, Houslay T, McCahill A, et al. 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. Cell Signal. 2007;19:2612-24 pubmed
    ..contains overlapping binding sites conferring interaction with the signaling scaffold proteins, betaarrestin and RACK1. A 38-mer peptide, whose sequence reflected residues 12 through 49 of PDE4D5, encompasses the entire N-terminal ..
  20. Yaka R, Thornton C, Vagts A, Phamluong K, Bonci A, Ron D. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002;99:5710-5 pubmed
    ..modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, ..
  21. Zhang W, Zong C, Hermanto U, Lopez Bergami P, RONAI Z, Wang L. RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth. Mol Cell Biol. 2006;26:413-24 pubmed
    ..Here we demonstrate a novel role of RACK1 as an adaptor for insulin and insulin-like growth factor 1 receptor (IGF-1R)-mediated STAT3 activation ..
  22. Shi S, Deng Y, Zhao J, Ji X, Shi J, Feng Y, et al. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem. 2012;287:7845-58 pubmed publisher
    ..Here, we found RACK1 (receptor of activated kinase 1) was elevated in most NSCLC, and its expression level correlated with key ..
  23. Bolger G, McCahill A, Yarwood S, Steele M, Warwicker J, Houslay M. Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5. BMC Biochem. 2002;3:24 pubmed
    The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the beta-propeller protein RACK1 to form a signaling scaffold complex in cells...
  24. Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A. Coordinated movement of RACK1 with activated betaIIPKC. J Biol Chem. 1999;274:27039-46 pubmed
    ..b>RACK1, the receptor for activated betaIIPKC, determines the localization and functional activity of betaIIPKC...
  25. Tcherkasowa A, Adam Klages S, Kruse M, Wiegmann K, Mathieu S, Kolanus W, et al. Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor. J Immunol. 2002;169:5161-70 pubmed
    ..Mapping studies in yeast revealed that RACK1 is recruited to the C-terminal WD-repeat region of FAN and binds to FAN through a domain located within WD repeats ..
  26. Chen S, Dell E, Lin F, Sai J, Hamm H. RACK1 regulates specific functions of Gbetagamma. J Biol Chem. 2004;279:17861-8 pubmed
    We showed previously that Gbetagamma interacts with Receptor for Activated C Kinase 1 (RACK1), a protein that not only binds activated protein kinase C (PKC) but also serves as an adaptor/scaffold for many signaling pathways...
  27. Smith P, de Jesus O, Turner D, Hollyoake M, Karstegl C, Griffin B, et al. Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus. J Virol. 2000;74:3082-92 pubmed
    ..The protein product of another CST ORF, A73, is shown to be a cytoplasmic protein which can interact with the cell RACK1 protein...
  28. Liu Y, Hubbi M, Pan F, McDonald K, Mansharamani M, Cole R, et al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem. 2007;282:37064-73 pubmed
    ..O2-independent degradation of HIF-1alpha is regulated by the competition of RACK1 and HSP90 for binding to HIF-1alpha...
  29. Chang B, Chiang M, Cartwright C. The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1. J Biol Chem. 2001;276:20346-56 pubmed
    b>RACK1 is an intracellular receptor for the serine/ threonine protein kinase C. Previously, we demonstrated that RACK1 also interacts with the Src protein-tyrosine kinase...
  30. Cao X, Xu J, Xu J, Liu X, Cheng Y, Wang W, et al. RACK1 promotes breast carcinoma proliferation and invasion/metastasis in vitro and in vivo. Breast Cancer Res Treat. 2010;123:375-86 pubmed publisher
    ..utilized to identify novel PI3K p110alpha-interacting proteins, of which receptor of activated protein kinase C1 (RACK1) was chosen for successive detailed analyses...
  31. Park H, Wu H, Killoran C, Gilchrest B. The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes. J Cell Sci. 2004;117:3659-68 pubmed
    ..Taken together, these results demonstrate that RACK-I anchors activated PKC-beta on the melanosome membrane, allowing PKC-beta to phosphorylate tyrosinase. ..
  32. Dell E, Connor J, Chen S, Stebbins E, Skiba N, Mochly Rosen D, et al. The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem. 2002;277:49888-95 pubmed
    ..Two of these proteins, the receptor for activated C kinase 1 (RACK1) and the dynein intermediate chain, co-immunoprecipitate with Gbetagamma using an anti-Gbeta antibody...
  33. Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, et al. Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). Int J Biochem Cell Biol. 2002;34:93-102 pubmed
    ..of a human fetal brain cDNA library, we have identified a new interaction partner of the human AGTRAP protein, RACK1 (Receptor of Activated Protein C Kinase)...
  34. Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M. Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci. 2011;102:2007-13 pubmed publisher
    ..Here, we show that receptor for activated C-kinase 1 (RACK1), a ubiquitously expressed scaffolding protein, plays a crucial regulatory role in tumor growth...
  35. Mamidipudi V, Cartwright C. A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene. 2009;28:4421-33 pubmed publisher
    Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src...
  36. Chang B, Conroy K, Machleder E, Cartwright C. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. Mol Cell Biol. 1998;18:3245-56 pubmed
    ..We identified RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, as a Src-binding protein...
  37. Huang J, Chuang N. Shift syndecan-2 from RACK1 to caveolin-2 upon transformation with oncogenic ras. Biochem Biophys Res Commun. 2006;350:227-32 pubmed
    Syndecan-2 was found to detach from RACK1 and associate with caveolin-2 and Ras in cells transformed with oncogenic ras. Most of syndecan-2 from transformed cells was revealed with negligible phosphorylations at tyrosine residues...
  38. Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, et al. RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK. Cell Rep. 2015;13:1407-1417 pubmed publisher
    ..However, the role of WD40-repeat-only proteins, such as RACK1, in postnatal mammalian physiology remains unknown...
  39. Tarnowski K, Fituch K, Szczepanowski R, Dadlez M, Kaus Drobek M. Patterns of structural dynamics in RACK1 protein retained throughout evolution: a hydrogen-deuterium exchange study of three orthologs. Protein Sci. 2014;23:639-51 pubmed publisher
    b>RACK1 is a member of the WD repeat family of proteins and is involved in multiple fundamental cellular processes. An intriguing feature of RACK1 is its ability to interact with at least 80 different protein partners...
  40. Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, et al. Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity. Oncol Rep. 2013;30:2195-202 pubmed publisher
    Glioma is the most common primary brain malignant tumor. Receptor for activated C-kinase 1 (RACK1) is widely expressed in the central nervous system, and regulates multiple cellular processes including cell survival, proliferation, ..
  41. Chiba Y, Tanabe M, Sakai H, Kimura S, Misawa M. A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells. Biochem Biophys Res Commun. 2010;401:487-90 pubmed publisher
    ..Using yeast two-hybrid system, we have identified the receptor for activated C kinase 1 (RACK1) as a novel interaction partner of CPI-17...
  42. Hu L, Lu F, Wang Y, Liu Y, Liu D, Jiang Z, et al. RACK1, a novel hPER1-interacting protein. J Mol Neurosci. 2006;29:55-63 pubmed
    ..b>RACK1 (receptor for activated protein kinase C-1), a member of the WD-40 family of proteins, can interact with numerous ..
  43. Gallina A, Rossi F, Milanesi G. Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor. Virology. 2001;283:7-18 pubmed
    ..Here the interaction of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is reported...
  44. Opitz N, Schmitt K, Hofer Pretz V, Neumann B, Krebber H, Braus G, et al. Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Mol Cell Proteomics. 2017;16:2199-2218 pubmed publisher
    ..g. of Bre5p), and by that might affect nuclear gene transcription and the fate of ribosomes. ..
  45. Sarmady M, Dampier W, Tozeren A. Sequence- and interactome-based prediction of viral protein hotspots targeting host proteins: a case study for HIV Nef. PLoS ONE. 2011;6:e20735 pubmed publisher
    ..experimental data on binding sites of Nef to host proteins such as MAPK1, VAV1, LCK, HCK, HLA-A, CD4, FYN, and GNB2L1 with high statistical significance but is a poor predictor of Nef binding sites on highly flexible, hoop-like ..
  46. Yaka R, He D, Phamluong K, Ron D. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003;278:9630-8 pubmed
    ..of the phosphorylation state and function of the N-methyl-d-aspartate (NMDA) receptor via the scaffolding protein RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein-tyrosine kinase, ..
  47. Zaid Y, Senhaji N, Naya A, Fadainia C, Kojok K. PKCs in thrombus formation. Pathol Biol (Paris). 2015;63:268-71 pubmed publisher
    ..In addition, PKCβ by interacting with its receptor RACK1 has been implicated in the primary phases of signaling via the αIIbβ3 and finally PKCɛ appears to be ..
  48. Gonçalves K, Borges J, Silva J, Papa P, Bressan G, Torriani I, et al. Solution structure of the human signaling protein RACK1. BMC Struct Biol. 2010;10:15 pubmed publisher
    The adaptor protein RACK1 (receptor of activated kinase 1) was originally identified as an anchoring protein for protein kinase C...
  49. Kim H, Kong E, Kim Y, Chang J, Kim J. RACK1 depletion in the ribosome induces selective translation for non-canonical autophagy. Cell Death Dis. 2017;8:e2800 pubmed publisher
    b>RACK1, which was first demonstrated as a substrate of PKCβ II, functions as a scaffold protein and associates with the 40S small ribosomal subunit...
  50. Li D, Shen F, Li H, Li W. Kale BoRACK1 is involved in the plant response to salt stress and Peronospora brassicae Gaumann. J Plant Physiol. 2017;213:188-198 pubmed publisher
    The receptor for activated C kinase 1 (RACK1) belongs to a protein subfamily containing a tryptophan-aspartic acid-domain (WD) repeat structure...
  51. Marques N, Sese M, Cánovas V, Valente F, Bermudo R, de Torres I, et al. Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1. Oncogene. 2014;33:1124-34 pubmed publisher
    ..Here we show that PTOV1 interacts directly with receptor of activated protein C kinase 1 (RACK1), a regulator of protein kinase C and Jun signaling and also a component of the 40S ..
  52. Buoso E, Galasso M, Ronfani M, Serafini M, Lanni C, Corsini E, et al. Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone. Pharmacol Res. 2017;120:180-187 pubmed publisher
    ..receptor ? (GR?) expression and antagonizing the binding of GR? to the glucocorticoid responsive element (GRE) in RACK1 (Receptor for Activated C Kinase 1) promoter...
  53. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 2010;3:ra7 pubmed publisher
    ..We found that the scaffold protein receptor for activated C-kinase 1 (RACK1) interacted with IRE1alpha in a glucose-stimulated or endoplasmic reticulum (ER) stress-responsive manner in ..
  54. Ikebuchi Y, Ito K, Takada T, Anzai N, Kanai Y, Suzuki H. Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2. Drug Metab Dispos. 2010;38:2320-8 pubmed publisher
    In a previous report, we identified the receptor for activated C-kinase 1 (RACK1) as a positive regulator of the cellular localization and expression of ATP-binding cassette B4, a phosphatidylcholine translocator expressed on the bile ..
  55. Bolger G. The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action. Adv Neurobiol. 2017;17:63-102 pubmed publisher
    ..may also be capable of targeting the interactions of select long forms with their "partner" proteins, such as RACK1, ?-arrestin, and DISC1...
  56. Xu X, Yang X, Xiong Y, Gu J, He C, Hu Y, et al. Increased expression of receptor for activated C kinase 1 in temporal lobe epilepsy. J Neurochem. 2015;133:134-43 pubmed publisher
    ..Here, we showed that receptor for activated C kinase 1 (RACK1) was expressed in the hippocampus and temporal cortex of the MTLE human brain...
  57. Boratkó A, Csortos C. TIMAP, the versatile protein phosphatase 1 regulator in endothelial cells. IUBMB Life. 2017;69:918-928 pubmed publisher
    ..TIMAP is prenylated by farnesyl transferase with the contribution of the anchoring protein, RACK1 in the cytoplasm...
  58. Zhou T, Lv X, Guo X, Ruan B, Liu D, Ding R, et al. RACK1 modulates apoptosis induced by sorafenib in HCC cells by interfering with the IRE1/XBP1 axis. Oncol Rep. 2015;33:3006-14 pubmed publisher
    ..In the present study, we found that the UPR was activated and RACK1 was overexpressed in three human HCC cell lines and in HCC samples...
  59. Sun Z, Tang X, Lin F, Chen S. The WD40 repeat protein WDR26 binds G?? and promotes G??-dependent signal transduction and leukocyte migration. J Biol Chem. 2011;286:43902-12 pubmed publisher
    ..Additional data show that WDR26 also controlled RACK1, a negative regulator, in binding G?? and inhibiting leukocyte migration...
  60. Li X, Xiao Y, Fan S, Xiao M, Wang X, Chen X, et al. RACK1 overexpression associates with pancreatic ductal adenocarcinoma growth and poor prognosis. Exp Mol Pathol. 2016;101:176-186 pubmed publisher
    The receptor for activated protein kinase C (RACK1) is a scaffold protein involved in multiple intracellular signal pathways...
  61. Mochly Rosen D, Miller K, Scheller R, Khaner H, Lopez J, Smith B. p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. Biochemistry. 1992;31:8120-4 pubmed
    ..Since the only homologous region between PKC and the p65 fragments is the C2 region, these results suggest that the C2 region on PKC contains at least part of the RACK binding site. ..
  62. Amir S, Wang R, Simons J, Mabjeesh N. SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation. J Biol Chem. 2009;284:11142-51 pubmed publisher
    ..HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation...
  63. Ellis J, Ashman C, Burden M, Kilpatrick K, Morse M, Hamblin P. GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. J Immunol. 2000;164:5805-14 pubmed
    ..These findings suggest that GRID functions as an adapter protein in the CD28-mediated costimulatory pathway in T cells. ..
  64. Yang R, Gaidamakov S, Xie J, Lee J, Martino L, Kozlov G, et al. La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. Mol Cell Biol. 2011;31:542-56 pubmed publisher
    ..two-hybrid analysis and reciprocal immunoprecipitations (IPs) from HeLa cells revealed that LARP4 interacts with RACK1, a 40S ribosome- and mRNA-associated protein...
  65. Croze E, Usacheva A, Asarnow D, Minshall R, Perez H, Colamonici O. Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor. J Immunol. 2000;165:5127-32 pubmed
    ..However, stimulation of cells with either IFN-beta1b or PMA did result in an increase in detectable immunofluorescence and intracellular redistribution of RACK-1. ..
  66. Dong Z, Tang L, Deng G, Zeng T, Liu S, Wan R, et al. Transcription of the human sodium channel SCN1A gene is repressed by a scaffolding protein RACK1. Mol Neurobiol. 2014;50:438-48 pubmed publisher
    ..Further analyses showed that a scaffolding protein RACK1 (receptor for activated C kinase 1) was involved in binding to this silencer...
  67. Lee K, Kim M, Kim D, Lee Y. Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Neurochem Res. 2004;29:1405-9 pubmed
    ..novel interactions between DAT, the SNARE protein syntaxin 1A, and the receptor for activated C kinases (RACK1). This association involves the intracellular N-terminal domain of human DAT (hDAT)...
  68. Myklebust L, Horvli O, Raae A. RACK1 (receptor for activated C-kinase 1) interactions with spectrin repeat elements. J Mol Recognit. 2015;28:49-58 pubmed publisher
    Receptor for activated C-kinase 1 (RACK1) is an intracellular scaffolding protein involved in a multitude of signalling pathways...
  69. Limoncelli K, Merrikh C, Moore M. ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay. RNA. 2017;23:1946-1960 pubmed publisher
    ..Here we identify Asc1p (aka RACK1) and Rps3p, both stable 40S subunit components, as additional 18S NRD factors...