RACK1

Summary

Gene Symbol: RACK1
Description: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Alias: Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1, cell proliferation-inducing gene 21 protein, guanine nucleotide-binding protein subunit beta-2-like 1, guanine nucleotide-binding protein subunit beta-like protein 12.3, human lung cancer oncogene 7 protein, lung cancer oncogene 7, proliferation-inducing gene 21, protein homologous to chicken B complex protein, guanine nucleotide binding, receptor for activated C kinase 1, receptor of activated protein kinase C 1
Species: human

Top Publications

  1. pmc Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C
    M H Disatnik
    Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305 5332
    Proc Natl Acad Sci U S A 91:559-63. 1994
  2. ncbi c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans
    B Hoffmann
    Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
    Mol Microbiol 37:28-41. 2000
  3. pmc Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1)
    Chen Feng
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 287:10714-26. 2012
  4. doi Structural basis and specificity of human otubain 1-mediated deubiquitination
    Mariola J Edelmann
    Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Biochem J 418:379-90. 2009
  5. doi Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis
    Feng Wang
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Dental and Medical University, Tokyo, Japan
    Cancer Sci 102:2007-13. 2011
  6. ncbi Shift syndecan-2 from RACK1 to caveolin-2 upon transformation with oncogenic ras
    Jin wen Huang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    Biochem Biophys Res Commun 350:227-32. 2006
  7. pmc RACK1 regulates G1/S progression by suppressing Src kinase activity
    Vidya Mamidipudi
    Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5187, USA
    Mol Cell Biol 24:6788-98. 2004
  8. ncbi Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly
    Marcello Ceci
    Molecular Histology Unit, DiBiT HSR, 20132 Milano, Italy
    Nature 426:579-84. 2003
  9. doi Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness
    X He
    Department of Urology, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 30:535-47. 2011
  10. ncbi The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1
    B Y Chang
    Department of Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 276:20346-56. 2001

Detail Information

Publications169 found, 100 shown here

  1. pmc Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C
    M H Disatnik
    Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305 5332
    Proc Natl Acad Sci U S A 91:559-63. 1994
    ....
  2. ncbi c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans
    B Hoffmann
    Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
    Mol Microbiol 37:28-41. 2000
    ..In the presence of amino acids, the gene product of the mammalian RACK1 homologue cpcB is required to repress the network...
  3. pmc Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1)
    Chen Feng
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 287:10714-26. 2012
    ..We provide evidence that kindlin-3 interacts with the receptor for activated-C kinase 1 (RACK1), a scaffold protein that folds into a seven-blade propeller...
  4. doi Structural basis and specificity of human otubain 1-mediated deubiquitination
    Mariola J Edelmann
    Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Biochem J 418:379-90. 2009
    ..also known as TLS (translocation in liposarcoma) or CHOP (CCAAT/enhancer-binding protein homologous protein)] and RACK1 [receptor for activated kinase 1; also known as GNB2L1 (guanine-nucleotide-binding protein beta polypeptide 2-like ..
  5. doi Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis
    Feng Wang
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Dental and Medical University, Tokyo, Japan
    Cancer Sci 102:2007-13. 2011
    ..Here, we show that receptor for activated C-kinase 1 (RACK1), a ubiquitously expressed scaffolding protein, plays a crucial regulatory role in tumor growth...
  6. ncbi Shift syndecan-2 from RACK1 to caveolin-2 upon transformation with oncogenic ras
    Jin wen Huang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    Biochem Biophys Res Commun 350:227-32. 2006
    Syndecan-2 was found to detach from RACK1 and associate with caveolin-2 and Ras in cells transformed with oncogenic ras. Most of syndecan-2 from transformed cells was revealed with negligible phosphorylations at tyrosine residues...
  7. pmc RACK1 regulates G1/S progression by suppressing Src kinase activity
    Vidya Mamidipudi
    Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5187, USA
    Mol Cell Biol 24:6788-98. 2004
    ..Cancer cells subvert controls at work at this restriction point and remain in cycle. Previously, we showed that RACK1 inhibits the oncogenic Src tyrosine kinase and NIH 3T3 cell growth...
  8. ncbi Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly
    Marcello Ceci
    Molecular Histology Unit, DiBiT HSR, 20132 Milano, Italy
    Nature 426:579-84. 2003
    ..In the cytoplasm, eIF6 is bound to free 60S but not to 80S. Furthermore, eIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C (PKC)...
  9. doi Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness
    X He
    Department of Urology, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 30:535-47. 2011
    ..Here, we show that the receptor for activated C kinase 1 (RACK1) is a novel pVHL-interacting protein...
  10. ncbi The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1
    B Y Chang
    Department of Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 276:20346-56. 2001
    b>RACK1 is an intracellular receptor for the serine/ threonine protein kinase C. Previously, we demonstrated that RACK1 also interacts with the Src protein-tyrosine kinase...
  11. pmc Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration
    Patrick A Kiely
    Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, National University of Ireland, Cork, Ireland
    Mol Cell Biol 26:4041-51. 2006
    The WD repeat scaffolding protein RACK1 can mediate integration of the insulin-like growth factor I receptor (IGF-IR) and integrin signaling in transformed cells...
  12. pmc Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome
    Jakob Nilsson
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    EMBO Rep 5:1137-41. 2004
    The receptor for activated C-kinase (RACK1) is a scaffold protein that is able to interact simultaneously with several signalling molecules. It binds to protein kinases and membrane-bound receptors in a regulated fashion...
  13. doi Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells
    Jing Li
    State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No 14, Sec 3, Renminnan Road, Chengdu 610041, Sichuan, China
    J Cancer Res Clin Oncol 138:563-71. 2012
    b>Receptor of activated protein kinase C 1 (RACK1) has been identified as an anchoring or adaptor protein in multiple intracellular signal transduction pathways...
  14. ncbi Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor
    A Gallina
    Department of Medicine and Surgery, Polo Universitario Ospedale San Paolo, University of Milano, Via A Di Rudini 8, I 20142 Milan, Italy
    Virology 283:7-18. 2001
    ..Here the interaction of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is reported...
  15. pmc Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome
    Miren David
    Instituto de Investigaciones Biomedicas, Madrid Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 287:21416-28. 2012
    ..5, K(v)β1.3, the receptor for activated C kinase (RACK1), PKCβI, PKCβII, and PKCθ in HEK293 cells. A very similar K(v)1...
  16. pmc SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation
    Sharon Amir
    Prostate Cancer Research Laboratory, Department of Urology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Biol Chem 284:11142-51. 2009
    ..HIF-1alpha from degradation induced by HSP90 inhibition by preventing the interaction of HIF-1alpha with the RACK1 protein, which promotes its oxygen-independent proteasomal degradation...
  17. ncbi The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex
    Anna Usacheva
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Immunol 171:2989-94. 2003
    ..Finally, we provide evidence that RACK-1 may also serve as a scaffold protein in other cytokine systems such as IL-2, IL-4, and erythropoietin...
  18. doi Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration
    Patrick A Kiely
    Department of Biochemistry, Biosciences Institute, University College Cork, Ireland
    J Biol Chem 283:22952-61. 2008
    ..regulates a mutually exclusive interaction of PP2A and beta1 integrin with the WD repeat scaffolding protein RACK1. This interaction is required for the integration of IGF-I receptor (IGF-IR) and adhesion signaling...
  19. ncbi Plectin-RACK1 (receptor for activated C kinase 1) scaffolding: a novel mechanism to regulate protein kinase C activity
    Selma Osmanagic-Myers
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Vienna Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
    J Biol Chem 279:18701-10. 2004
    ..We show here sequestering of receptor for activated C kinase 1 (RACK1) to the cytoskeleton through the cytoskeletal linker protein plectin during the initial ..
  20. pmc RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth
    Weizhou Zhang
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Mol Cell Biol 26:413-24. 2006
    ..Here we demonstrate a novel role of RACK1 as an adaptor for insulin and insulin-like growth factor 1 receptor (IGF-1R)-mediated STAT3 activation ..
  21. ncbi The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor
    A Usacheva
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 276:22948-53. 2001
    ..IFN receptor and STAT1 is not direct but mediated by the adapter protein receptor for activated protein kinase C (RACK1)...
  22. ncbi Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension
    Anna Zakrzewicz
    University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Circulation 115:2957-68. 2007
    ..Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that alterations to BMPRII function are involved in disease onset and/or progression...
  23. ncbi Coordinated movement of RACK1 with activated betaIIPKC
    D Ron
    Department of Neurology, University of California, San Francisco, California 94110 3518, USA
    J Biol Chem 274:27039-46. 1999
    ..b>RACK1, the receptor for activated betaIIPKC, determines the localization and functional activity of betaIIPKC...
  24. ncbi A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons
    Frank Angenstein
    Beckman Institute Neuronal Pattern Analysis, University of Illinois, Urbana, Illinois 61801, USA
    J Neurosci 22:8827-37. 2002
    ..Here we report that a receptor for activated C kinase, RACK1, is a component of messenger ribonucleoprotein (mRNP) complexes...
  25. pmc Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins
    D Ron
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305 5332
    Proc Natl Acad Sci U S A 91:839-43. 1994
    ..In the following study, we describe the cloning of a cDNA encoding a 36-kDa protein (RACK1) that fulfills the criteria for RACKs...
  26. ncbi RACK1 regulates specific functions of Gbetagamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 279:17861-8. 2004
    We showed previously that Gbetagamma interacts with Receptor for Activated C Kinase 1 (RACK1), a protein that not only binds activated protein kinase C (PKC) but also serves as an adaptor/scaffold for many signaling pathways...
  27. doi Receptor for activated C-kinase 1, a novel binding partner of adiponectin receptor 1
    Yizhou Xu
    Department of Cardiology, Hangzhou the First People s Hospital, 261 Wansha Road, Hangzhou 310006, China
    Biochem Biophys Res Commun 378:95-8. 2009
    ..Using a yeast two-hybrid screen, we identified an adaptor protein, receptor for activated protein kinase C1 (RACK1), as an interacting partner of human AdipoR1...
  28. ncbi RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death
    Patrick A Kiely
    Cell Biology Laboratory, Department of Biochemistry and Bioscience Institute, National University of Ireland, Lee Maltings Cork, Ireland
    J Biol Chem 277:22581-9. 2002
    ..This screen identified Receptor for Activated C Kinases (RACK1) as an IGF-1R-interacting protein...
  29. pmc Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C
    Rebecca J Bird
    Institute of Molecular Cell and Systems Biology, University of Glasgow, Scotland, UK
    Biochem J 432:207-16. 2010
    We have previously identified the PKC (protein kinase C)-anchoring protein RACK1 (receptor for activated C-kinase 1), as a specific binding partner for the cAMP-specific phosphodiesterase PDE4D5, suggesting a potential site for cross-..
  30. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:9630-8. 2003
    ..of the phosphorylation state and function of the N-methyl-d-aspartate (NMDA) receptor via the scaffolding protein RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein-tyrosine kinase, ..
  31. ncbi RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization
    Ye V Liu
    Vascular Biology Program, Institute of Cell Engineering, Department of Pediatrics, and McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Cycle 6:656-9. 2007
    ..Recently, we reported the identification of receptor of activated protein C kinase (RACK1) as a novel HIF-1alpha interacting protein...
  32. pmc Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization
    Ye V Liu
    Vascular Program, Institute for Cell Engineering, Department of Pharmacology and Molecular Sciences, Mass Spectronomy Proteomics Facility, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 282:37064-73. 2007
    ..O2-independent degradation of HIF-1alpha is regulated by the competition of RACK1 and HSP90 for binding to HIF-1alpha...
  33. ncbi Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit
    J Liliental
    Department of Medicine, Microbiology and Immunology, University of California at Los Angeles School of Medicine 90095, USA
    J Biol Chem 273:2379-83. 1998
    ..We report an interaction between integrin beta subunit cytoplasmic domain and Rack1, a Trp-Asp (WD) repeat protein that has been shown to bind activated protein kinase C...
  34. ncbi The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins
    M Rietzler
    Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universitat, Trogerstrasse 4a, D 81675 Munchen, Germany
    J Biol Chem 273:27459-66. 1998
    ..These results suggest that WAIT-1, together with the recently identified RACK1, may define a novel subfamily of WD repeat proteins that interact with distinct subsets of integrin cytoplasmic ..
  35. pmc Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase
    Patrick A Kiely
    From the Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    J Biol Chem 284:20263-74. 2009
    ..The scaffolding protein RACK1 (receptor for activated C kinases) integrates insulin-like growth factor I (IGF-I) and integrin signaling, but ..
  36. ncbi Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor
    N Geijsen
    Department of Pulmonary Diseases, University Hospital Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands
    Oncogene 18:5126-30. 1999
    ..We found that RACK1, a molecule associating with activated PKC, PLCgamma and Src kinases, associated with the membrane proximal region ..
  37. ncbi The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts
    T Mourton
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Biol Chem 276:14896-901. 2001
    ..Sequencing of two positive clones identified the scaffolding protein RACK1 (receptor for activated protein C kinase) as a PTPmu interacting protein...
  38. ncbi Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brazil
    Biochem Biophys Res Commun 341:847-55. 2006
    Ki-1/57 is a cytoplasmic and nuclear phospho-protein of 57 kDa and interacts with the adaptor protein RACK1, the transcription factor MEF2C, and the chromatin remodeling factor CHD3, suggesting that it might be involved in the regulation ..
  39. pmc Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
    Graeme B Bolger
    Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Biochem J 398:23-36. 2006
    ..Two-hybrid and co-immunoprecipitation analyses showed that RACK1 and beta-arrestin interact with PDE4D5 in a mutually exclusive manner...
  40. ncbi Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor
    Anna Ewgenjewna Tcherkasowa
    Institut für Immunologie and I Medizinische Klinik, Christian Albrechts Universitat Kiel, Germany
    J Immunol 169:5161-70. 2002
    ..Mapping studies in yeast revealed that RACK1 is recruited to the C-terminal WD-repeat region of FAN and binds to FAN through a domain located within WD repeats ..
  41. ncbi Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 279:11444-55. 2004
    ..We used the yeast two-hybrid system to find proteins interacting with Ki-1/57 and identified the adaptor protein RACK1 (receptor of activated kinase 1)...
  42. ncbi The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins
    Edward J Dell
    Institute for Neuroscience and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60613, USA
    J Biol Chem 277:49888-95. 2002
    ..Two of these proteins, the receptor for activated C kinase 1 (RACK1) and the dynein intermediate chain, co-immunoprecipitate with Gbetagamma using an anti-Gbeta ..
  43. ncbi 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1
    K John Smith
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, PO Box 363, B15 2TT, UK
    Cell Signal 19:2612-24. 2007
    ..contains overlapping binding sites conferring interaction with the signaling scaffold proteins, betaarrestin and RACK1. A 38-mer peptide, whose sequence reflected residues 12 through 49 of PDE4D5, encompasses the entire N-terminal ..
  44. ncbi The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility
    Arnaud Besson
    Department of Oncology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:22073-84. 2002
    ..We provide novel evidence that the scaffolding protein RACK1 mediates the interaction between integrin beta chain and activated PKCepsilon...
  45. ncbi RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)
    Audrey Parent
    Service de Rhumatologie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada
    Traffic 9:394-407. 2008
    ..This screen identified receptor for activated C-kinase 1 (RACK1) as a new TPbeta-interacting protein...
  46. ncbi Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)
    Wei Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Int J Biochem Cell Biol 34:93-102. 2002
    ..of a human fetal brain cDNA library, we have identified a new interaction partner of the human AGTRAP protein, RACK1 (Receptor of Activated Protein C Kinase)...
  47. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
    ..modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, ..
  48. ncbi Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1
    J M Pass
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 281:H2500-10. 2001
    ..for activated C kinase (RACKs) have been shown to direct PKC signal transduction, the mechanism through which RACK1, a selective PKC beta II RACK, participates in PKC beta II-mediated cardiac hypertrophy and failure remains ..
  49. pmc RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells
    B Y Chang
    Department of Medicine, Stanford University, Stanford, California 94305, USA
    Mol Cell Biol 18:3245-56. 1998
    ..We identified RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, as a Src-binding protein...
  50. pmc Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5
    Graeme B Bolger
    Veterans Affairs Medical Center, Huntsman Cancer Institute, Division of Oncology, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84148, USA
    BMC Biochem 3:24. 2002
    The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the beta-propeller protein RACK1 to form a signaling scaffold complex in cells...
  51. ncbi The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform
    S J Yarwood
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biology and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 274:14909-17. 1999
    The WD-repeat protein receptor for activated C-kinase (RACK1) was identified by its interaction with the cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4D5 in a yeast two-hybrid screen...
  52. ncbi The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-beta on melanosomes
    Hee Young Park
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    J Cell Sci 117:3659-68. 2004
    ..Taken together, these results demonstrate that RACK-I anchors activated PKC-beta on the melanosome membrane, allowing PKC-beta to phosphorylate tyrosinase...
  53. pmc Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
    Ranjana Arya
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 167:1147-59. 2004
    ..MURF1 interacts with receptor for activated protein kinase C (RACK1) and colocalizes with RACK1 after activation with phenylephrine or PMA...
  54. ncbi A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase
    K M Pumiglia
    Parke Davis Pharmaceutical Research Division, Department of Signal Transduction, Ann Arbor, Michigan 48106, USA
    J Biol Chem 270:14251-4. 1995
    ..The identification and characterization of this novel interaction raises several possibilities for signaling cross-talk between growth factor receptors and those receptors coupled to heterotrimeric G-proteins...
  55. ncbi Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha
    Jin H Baek
    Vascular Program, Institute for Cell Engineering, The Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology
    J Biol Chem 282:33358-66. 2007
    ..HSP90 competes with RACK1 for binding to HIF-1alpha, and HSP90 inhibition leads to increased binding of RACK1, which recruits the Elongin C ..
  56. ncbi Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor
    E Croze
    Department of Immunology, Berlex Biosciences, Richmond CA 94804, USA
    J Immunol 165:5127-32. 2000
    ..However, stimulation of cells with either IFN-beta1b or PMA did result in an increase in detectable immunofluorescence and intracellular redistribution of RACK-1...
  57. pmc RACK1 mediates activation of JNK by protein kinase C [corrected]
    Pablo Lopez-Bergami
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell 19:309-20. 2005
    ..Here, we demonstrate that the receptor for activated C kinase 1 (RACK1) serves as an adaptor for PKC-mediated JNK activation...
  58. ncbi Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    Sarah Kraus
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 66:11047-54. 2006
    ..We show herein that the adaptor/scaffolding protein receptor for activated C kinase 1 (RACK1), which was previously reported to interact with the AR, modulates the tyrosine ..
  59. ncbi Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21)
    Andreas Peyrl
    University of Vienna, Department of Pediatrics, Austria
    Electrophoresis 23:152-7. 2002
    ..Four 14-3-3 protein isoforms, mitogen-activated protein kinase 1, receptor for activited kinase 1 (RACK1), constitutive photomorphogenesis (COP9) complex subunit 4 and cAMP-dependent protein kinase type II have been ..
  60. pmc Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus
    P R Smith
    Virology and Cell Biology, Imperial College School of Medicine, London W2 1PG, United Kingdom
    J Virol 74:3082-92. 2000
    ..The protein product of another CST ORF, A73, is shown to be a cytoplasmic protein which can interact with the cell RACK1 protein...
  61. ncbi Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5
    M R Steele
    Veterans Affairs Medical Center, Huntsman Cancer Institute, Department of Medicine Division of Oncology and Oncological Science, University of Utah Health Sciences Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA
    Cell Signal 13:507-13. 2001
    ..followed by yeast two-hybrid assay was used to determine the sites on the WD-repeat protein Receptor for Activated C Kinase 1 (RACK1) necessary for it to interact with the cAMP-specific phosphodiesterase isoform PDE4D5...
  62. ncbi Phorbol-myristate-acetate, but not interleukin-1 beta or insulin-like growth factor-I, regulates protein kinase C isoenzymes in human dermal papilla cells
    W Eicheler
    Department of Dermatology, Philipp University, Marburg, Germany
    Acta Derm Venereol 77:361-4. 1997
    ..By Western blot analysis, protein kinase C alpha, -epsilon, -gamma, -iota, -lambda, and the RACK1 receptor protein were detected in dermal papilla cell cultures, whereas the isoenzymes delta and mu were expressed ..
  63. ncbi Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts
    Vidar A T Thorsen
    Department of Biochemistry and Molecular Biology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Biochim Biophys Acta 1632:62-71. 2003
    ..expressing the HAbetaC2-1 peptide (Cl8 HAbetaC2-1 cells), with a sequence (betaC2-1) shown to bind receptor for activated C kinase 1 (RACK1) and inhibit c-PKC-mediated cell functions [Science 268 (1995) 247]...
  64. pmc Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)
    Aoife Guiry
    National University of Ireland, Galway, University Road, Galway, Ireland
    BMC Genomics 11:211. 2010
    ..The microarray has been populated with genes selected specifically for involvement in sexual maturation (precocious and adult) and in the parr-smolt transformation...
  65. ncbi An enhanced association of RACK1 with Abl in cells transfected with oncogenic ras
    Chin Ching Huang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    Int J Biochem Cell Biol 40:423-31. 2008
    The cellular RACK1 was shown in association with Abl in BALB/3T3 cells transfected with S-ras(Q(61)K) by immunoprecipitation...
  66. pmc P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state
    Maria Camats
    Unidad de Splicing, Instituto de Investigaciones Biomédicas de Barcelona Consejo Superior de Investigaciones Científicas, Barcelona, Spain
    PLoS ONE 4:e8513. 2009
    ..showed that p19 did not interact with two known p21 effectors, Raf1 and Rin1, but was shown to interact with RACK1, a scaffolding protein that promotes multi-protein complexes in different signaling pathways (Cancer Res 2003, 63 ..
  67. doi Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1
    Shin ichi Imai
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochim Biophys Acta 1791:246-53. 2009
    ..We identified aa 184-317 (WD40 repeats 5-7) of receptor for activated C kinase 1 (RACK1), which interacts with various important signaling molecules, as a novel binding partner of ..
  68. ncbi RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells
    Bodil Bjørndal
    Department of Molecular Biology, University of Bergen, Bergen, Norway
    Int J Cancer 120:961-9. 2007
    ..Ras-mediated morphological transformation encoded by a truncated version of the receptor for activated C-kinase (RACK1)...
  69. doi Toxoplasma gondii: proteomic analysis of antigenicity of soluble tachyzoite antigen
    Guang Yuan Ma
    Department of Parasitology, Shanxi Medical University, No 56 Xinjian Nan Road, Taiyuan, Shanxi 030001, PR China
    Exp Parasitol 122:41-6. 2009
    ..putative glutamate dehydrogenase (GDH), a coronin, a heat shock protein 70 (Hsp70), a protein kinase C receptor 1 (RACK1), a malate dehydrogenase (MDH), a major surface antigen 1 (SAG1), an uridine phosphorylase (UPase) and a ..
  70. doi Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions
    Inbal Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Chem Biol Interact 175:11-21. 2008
    ..to both N-AChE-R and AChE-R interacts either with the glycolytic enzyme enolase or with the scaffold protein RACK1. In vitro, the AChE-R C-terminal peptide ARP elevated enolase's activity by 12%, suggesting physiological ..
  71. pmc The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex
    Beatriz Aranda-Orgilles
    Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195, Berlin, Germany
    Hum Genet 123:163-76. 2008
    ..factor 1alpha (EF-1alpha) and several other proteins involved in mRNA transport and translation, including RACK1, Annexin A2, Nucleophosmin and proteins of the small ribosomal subunits...
  72. ncbi Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation
    Alessia Pascale
    Laboratory of Adaptive Systems, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 46:169-82. 2004
    ..the modality of PKC-betaII translocation as far as the participation of the receptor for activated C kinase-1 (RACK1) and the requirement for intact cytoskeleton in the process...
  73. ncbi Trap RACK1 with Ras to mobilize Src signaling at syndecan-2/p120-GAP upon transformation with oncogenic ras
    Jin wen Huang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    Biochem Biophys Res Commun 330:1087-94. 2005
    HiTrap-syndecan-2/p120-GAP and HiTrap-syndecan-2/RACK1 affinity columns were applied to reveal that Src tyrosine kinase was highly expressed in BALB/3T3 cells transfected with plasmids pcDNA3.1-[S-ras(Q(61)K)] of shrimp Penaeus japonicus...
  74. ncbi P120-GAP associated with syndecan-2 to function as an active switch signal for Src upon transformation with oncogenic ras
    Jin wen Huang
    Division of Biochemistry and Molecular Science, Institute of Zoology, Academia Sinica, Nankang, 11529 Taipei, Taiwan
    Biochem Biophys Res Commun 329:855-62. 2005
    ..and p120-GAP, we further purified p120-GAP protein from mouse brains by using an affinity column of HiTrap-RACK1 and expressed mouse RACK1-encoded fusion protein and mouse syndecan-2-encoded fusion protein in bacteria...
  75. doi Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like
    Yoshihiko Sugihara
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Proteome Res 9:1351-66. 2010
    ..This system allowed identification of 78 ribosomal proteins and Rack1 from a single gel...
  76. pmc Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages
    Enrica Calura
    Department of Biology, University of Ferrara, Ferrara, Italy
    BMC Genomics 9:630. 2008
    ..In this study we applied meta-analysis on gene expression signatures pertaining to different types of muscle atrophy for the identification of novel key regulatory signals implicated in these degenerative processes...
  77. ncbi Dimerize RACK1 upon transformation with oncogenic ras
    Ling Yun Chu
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    Biochem Biophys Res Commun 330:474-82. 2005
    ..And, RACK1 protein was reactive with syndecan-2 to keep Src inactivated, but not when Ras was overexpressed...
  78. pmc The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C
    Heike Möhlig
    Institut fur Immunologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstr 5, 24105 Kiel, Germany
    Exp Cell Res 313:2703-18. 2007
    ..Our results demonstrate that activation of PKC is not required for regulation of N-SMase by FAN/RACK1. Conversely, activation of PKC and recruitment/stabilization by RACK1 occurs uniformly in the presence or absence ..
  79. ncbi Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation
    H Luo
    Laboratory of Nephrology and Transplantation Immunology, Notre Dame Hospital Research Center, Montreal, Quebec, Canada
    J Cell Biochem 60:495-507. 1996
    ..The restricted expression of the gene in certain tissues and the activation-related expression in lymphocytes suggest that this gene might be necessary for optimal functions in heart, muscle, and the activated lymphocytes...
  80. ncbi Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling
    Noa Farchi
    Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Neurodegener Dis 4:171-84. 2007
    ..Peripheral anionic site (PAS) blockade of acetylcholinesterase (AChE) notably affects neuronal activity and cyto-architecture, however, the mechanism(s) involved are incompletely understood...
  81. doi Proteomic profiling of a high-producing Chinese hamster ovary cell culture
    Tyler Carlage
    Biogen Idec, 15 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Anal Chem 81:7357-62. 2009
    ..Several proteins involved in regulation of the cell cycle such as RACK1 and GTPase Ran were found to be differentially expressed, which may be due to a differentially controlled cell ..
  82. pmc Germination behavior, biochemical features and sequence analysis of the RACK1/arcA homolog from Phaseolus vulgaris
    Tania Islas-Flores
    Departamento de Biologia Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Physiol Plant 137:264-80. 2009
    ..with the reported soybean G(beta)-subunit, 86% with RACK1B and C from Arabidopsis and 66% with human and mouse RACK1, at the amino acid level. In addition, it showed 85...
  83. ncbi Roles for beta II-protein kinase C and RACK1 in positive and negative signaling for superoxide anion generation in differentiated HL60 cells
    H M Korchak
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Joseph Stokes, Jr Research Institute of the Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:8910-7. 2001
    ..fMet-Leu-Phe triggered association of a cytosolic NADPH oxidase component, p47(phox), with betaII-PKC but not with RACK1, a binding protein for betaII-PKC...
  84. pmc Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma
    Zhi Wang
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Chengdu 610041, Sichuan, China
    Mol Cell Proteomics 7:1639-50. 2008
    ..Of the eight newly implicated proteins, RACK1 was chosen for detailed analysis...
  85. ncbi Aging-related alterations in the distribution of Ca(2+)-dependent PKC isoforms in rabbit hippocampus
    E A Van der Zee
    Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
    Hippocampus 14:849-60. 2004
    ..A concurrent dramatic loss of the PKC anchoring protein receptor for activated C kinase (RACK1) in the pellet fraction was shown by Western blotting...
  86. doi A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity
    Bryan Serrels
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
    Curr Biol 20:1086-92. 2010
    ..pathway that links the integrin effector focal adhesion kinase (FAK), the molecular scaffold protein RACK1, and activity of one of its client proteins, PDE4D5, a cAMP-degrading phosphodiesterase...
  87. ncbi The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon
    M Csukai
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5332, USA
    J Biol Chem 272:29200-6. 1997
    ..Our laboratory has previously isolated one such protein, RACK1, and demonstrated that this protein displays specificity for PKCbeta...
  88. ncbi Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, Chuo Ku, 060 8556, Sapporo, Japan
    Virology 306:135-46. 2003
    ..immunoprecipitation experiments using antibodies against type 1 IFN receptor chain 1 (INFAR1) and antibody against RACK1, which is reported to be a scaffold protein interacting with type I IFN receptor chain 2 and STAT1...
  89. doi Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling
    John T Heiker
    Institute of Biochemistry, Faculty of Biociences, Pharmacy and Psychology, Leipzig University, Bruderstrasse 34, Leipzig, Germany
    Cell Signal 21:936-42. 2009
    ..With the exception of APPL1 and RACK1, no intracellular binding partners of adiponectin receptors are reported and thus signaling pathways downstream of ..
  90. ncbi Receptor activated C kinase is down-regulated in the male gonad of the marine bivalve mollusc Mya arenaria exposed to tributyltin (TBT)
    A Siah
    Laboratory of Ecotoxicology, University of Le Havrse, 25 rue P Lebon, BP 540, 76058 Le Havre Cedex, France
    Aquat Toxicol 83:295-305. 2007
    ..Among the potentially differentially regulated transcripts, Receptor for activated C kinase 1 (RACK1) represented 6% of the total down-regulated clones in males and the corresponding protein ..
  91. ncbi Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
    Yuki Ikebuchi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Hepatol Res 39:1091-107. 2009
    ..This screening allowed us to identify the receptor for activated C-kinase 1 (RACK1) as a novel binding partner of ABCB4...
  92. pmc Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase
    Andrés Núñez
    Department of Genetics and Microbiology, Facultad de Biologia, Universidad de Murcia, 30071 Murcia, Spain
    J Biol Chem 285:41366-73. 2010
    ..The receptor of activated C kinase (RACK1) is a scaffolding protein strongly conserved among eukaryotes which binds to other proteins to regulate multiple ..
  93. doi Eukaryotic ribosomes host PKC activity
    Stefano Grosso
    Laboratory of Molecular Histology and Cell Growth, DIBIT, Via Olgettina 58, HSR, 20132 Milano, Italy
    Biochem Biophys Res Commun 376:65-9. 2008
    PKC isoform betaII modulates translation and can be recruited on ribosomes via its scaffold RACK1 (receptor for activated protein kinase C 1), which resides on the 40S ribosomal subunit...
  94. pmc Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha
    Ana Maria Gaboreanu
    Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 177:707-16. 2007
    ..We have now identified a 65-kD adaptor protein that links P0 with the receptor for activated C kinase 1 (RACK1). The interaction of p65 with P0 maps to residues 179-197 within the cytoplasmic tail of P0...
  95. ncbi Identification of a receptor for activated protein kinase C1 (Pm-RACK1), a cellular gene product from black tiger shrimp (Penaeus monodon) interacts with a protein, VP9 from the white spot syndrome virus
    Moltira Tonganunt
    Center for Genomics and Bioinformatics Research, Faculty of Science, Prince of Songkla University, 15 Karnjanavanit Road, Songkhla 90110, Thailand
    Fish Shellfish Immunol 26:509-14. 2009
    ..encoding a receptor for activated protein kinase C1 homolog has been isolated from the shrimp, Penaeus monodon (Pm-RACK1)...
  96. ncbi Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
    ..GEMM) and megakaryocyte (Mk) colonies, which showed intensified labeling of AChE-R and its interacting proteins RACK1 and PKC...
  97. pmc The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin
    Nebojsa Knezevic
    Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Exp Med 206:2761-77. 2009
    ..We observed that in the naive endothelium Gbeta1, the predominant Gbeta isoform is sequestered by receptor for activated C kinase 1 (RACK1)...
  98. ncbi A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophages
    E Corsini
    Institute of Pharmacological Sciences, University of Milan, Italy
    J Immunol 163:3468-73. 1999
    ..from LPS-stimulated rat alveolar macrophages were determined and correlated with a decrease in the level of RACK1, the anchoring protein involved in protein kinase C translocation and activation...
  99. ncbi Hypoxia-inducible factor 1 (HIF-1) pathway
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Sci STKE 2007:cm8. 2007
    ..b>Receptor for activated C kinase 1 (RACK1) competes with heat shock protein 90 (HSP90) for binding to HIF-1alpha and mediates O2-..
  100. ncbi Is arcA3 a possible mediator in the signal transduction pathway during agonist cell cycle arrest by salicylic acid and UV irradiation?
    C Perennes
    Laboratoire Cycle Cellulaire et Recombinaison, Institut de Biotechnologie des Plantes, CNRS UMR 8618, Universite de Paris Sud, Bat 630, Plateau du Moulon, F 91405 Orsay cedex, France
    J Cell Sci 112:1181-90. 1999
    ..Since arcA3 is 67% similar to RACK1 (functional homology), a rat intracellular receptor for protein kinase C, and possesses identical PKC fixation ..
  101. doi Epstein-Barr virus BART gene expression
    Maha Al-Mozaini
    Department of Virology, Imperial College London, Norfolk Place, London, UK
    J Gen Virol 90:307-16. 2009
    ..1 cells. Artificially expressed A73 protein was known to be able to bind to the cellular RACK1 protein and has now also been shown to be able to regulate calcium flux, presumably via RACK1...

Research Grants66

  1. INTESTINAL CELL GROWTH CONTROL: ROLE OF TYROSINE KINASES
    CHRISTINE CARTWRIGHT; Fiscal Year: 2005
    ..Using a yeast two-hybrid assay, the PI recently identified RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, as a novel Src SH2-binding ..
  2. PTP MU REGULATES NEURITE OUTGROWTH /RETINAL DEVELOPMENT
    SUSANN BRADY KALNAY; Fiscal Year: 2005
    ..Is the PTPu interacting protein, RACK1, involved in sending signals that regulate neurite outgrowth on a PTPu substrate? A...
  3. Novel Strategy for Lung Cancer Treatment Using IGF-1R Inhibitor
    Ho Young Lee; Fiscal Year: 2009
    ..activation of IGF-1R signaling, we found that NNK stimulation resulted in the association of IGF-1R and RACK1, a scaffold protein that binds to a number of signaling molecules and regulates their function, in parallel with ..
  4. Novel Strategy for Lung Cancer Treatment Using IGF-1R Inhibitor
    Ho Young Lee; Fiscal Year: 2010
    ..activation of IGF-1R signaling, we found that NNK stimulation resulted in the association of IGF-1R and RACK1, a scaffold protein that binds to a number of signaling molecules and regulates their function, in parallel with ..
  5. Atypical G protein signaling in Cryptococcus neoformans
    Ping Wang; Fiscal Year: 2010
    ..Using Gpa1 as protein bait and through a yeast two-hybrid screen, we have identified a novel G2- like/RACK1 protein, Gib2, which exhibits a G2-like function by association with Gpa1 and G3 subunits Gpg1 and Gpg2...
  6. Function of ATF2 URE binding protein in human melanoma
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..Studies supported by this grant led to the discovery that RACK1 mediates JNK activation by PKC, which is required for activation of JNK by diverse stimuli...
  7. Function of ATF2 URE binding protein in human melanoma
    ZE EV RONAI; Fiscal Year: 2007
    ..Studies supported by this grant led to the discovery that RACK1 mediates JNK activation by PKC, which is required for activation of JNK by diverse stimuli...
  8. TRACK Regulates Cytokinesis in Trypanosoma brucei
    LAWRENCE RUBEN; Fiscal Year: 2007
    ..recently identified a putative signal anchor protein called TRACK with strong similarity to mammalian and yeast RACK1/Cpc2. We report that TRACK can correct morphological and growth related defects in cpc2 null mutants of S. pombe...
  9. ADHESIVE REGULATION DURING CELL MIGRATION
    Anna Huttenlocher; Fiscal Year: 2004
    ..candidate regulators, including a protein with sequence homology to the protein kinase C-binding protein RACK1. To characterize the molecular mechanisms that regulate integrin- cytoskeletal interactions during migration we ..
  10. Human Colon Cancer: Role of the Src Tyrosine Kinase
    CHRISTINE CARTWRIGHT; Fiscal Year: 2007
    ..We recently identified RACK1 as a novel Src substrate and binding partner and an inhibitor of Src activity and cell growth...
  11. PO-Mediated Signaling and Myelination
    Jack Lilien; Fiscal Year: 2006
    ..1) We have found that RACK1, the Receptor for Activated C Kinase is a component of the complex of proteins associated with the cytoplasmic ..
  12. INTESTINAL CELL GROWTH CONTROL: ROLE OF TYROSINE KINASES
    CHRISTINE CARTWRIGHT; Fiscal Year: 2007
    ..Our research focuses on molecular mechanisms by which the Src kinases contribute to the regulation. We identified RACK1 as a novel substrate and binding partner of Src, and an inhibitor of Src kinases and colonic cell growth...
  13. INTESTINAL CELL GROWTH CONTROL: ROLE OF TYROSINE KINASES
    CHRISTINE ANN CARTWRIGHT; Fiscal Year: 2010
    ..Our research focuses on molecular mechanisms by which the Src kinases contribute to the regulation. We identified RACK1 as a novel substrate and binding partner of Src, and an inhibitor of Src kinases and colonic cell growth...
  14. PROTEIN KINASE C IN ISCHEMIC RENAL INJURY AND REPAIR
    Babu Padanilam; Fiscal Year: 2002
    ..We have shown that the expression of several PKC isozymes and the receptor for activated C-kinase(RACK1) are enhanced following ischemic renal injury...
  15. GABA-A RECEPTOR STRUCTURE AND FUNCTION
    Richard Olsen; Fiscal Year: 2003
    ..b>RACK1 (receptor for activated C-kinase), links protein kinase C-beta to GABAR alpha1 subunit, probably for regulating ..
  16. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    CHRISTINA DANIELS; Fiscal Year: 2007
    ..Initial results show Orf B shuttles between the nucleus and cytoplasm, interacts with Receptor for Activated C Kinase 1 (RACK1), interacts with separate complexes containing PKC beta II and protein phosphatase 2A (PP2A), ..
  17. BETA-3 INTEGRIN TYROSINE PHOSPHORYLATION
    SCOTT BLYSTONE; Fiscal Year: 2005
    ..Experiments contained in this application will determine if the candidate molecule RACK1 binds to tyrosine phosphorylated b3 integrins and coordinates their response to PKC activation...