RAB9A

Summary

Gene Symbol: RAB9A
Description: RAB9A, member RAS oncogene family
Alias: RAB9, ras-related protein Rab-9A, RAB9, member RAS oncogene family
Species: human
Products:     RAB9A

Top Publications

  1. Ganley I, Pfeffer S. Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells. J Biol Chem. 2006;281:17890-9 pubmed
    ..cholesterol accumulation influences late endosome function, we investigated the effect of elevated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment. Endogenous Rab9 levels were elevated 1...
  2. Soldati T, Riederer M, Pfeffer S. Rab GDI: a solubilizing and recycling factor for rab9 protein. Mol Biol Cell. 1993;4:425-34 pubmed
    ..quot; We show here that the cytosolic form of rab9, a protein required for transport between late endosomes and the trans Golgi network, also occurs as a complex with ..
  3. Diaz E, Schimmöller F, Pfeffer S. A novel Rab9 effector required for endosome-to-TGN transport. J Cell Biol. 1997;138:283-90 pubmed
    b>Rab9 GTPase is required for the transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network in living cells, and in an in vitro system that reconstitutes this process...
  4. Ganley I, Carroll K, Bittova L, Pfeffer S. Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. Mol Biol Cell. 2004;15:5420-30 pubmed
    b>Rab9 GTPase resides in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and the tail-interacting protein of 47 kDa (TIP47)...
  5. Hanna J, Carroll K, Pfeffer S. Identification of residues in TIP47 essential for Rab9 binding. Proc Natl Acad Sci U S A. 2002;99:7450-4 pubmed
    ..two receptors, and its ability to bind to the cation-independent MPR is enhanced by the concomitant binding of the Rab9 GTPase. We show here that TIP47 residues 161-169 are essential, but likely not sufficient, for Rab9 binding...
  6. Carroll K, Hanna J, Simon I, Krise J, Barbero P, Pfeffer S. Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. Science. 2001;292:1373-6 pubmed
    ..Here we show that TIP47 also bound directly to the Rab9 guanosine triphosphatase (GTPase) in its active, GTP-bound conformation...
  7. Murray J, Mavrakis M, McDonald N, Yilla M, Sheng J, Bellini W, et al. Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus. J Virol. 2005;79:11742-51 pubmed publisher
    ..By using gene trap insertional mutagenesis, we identified Rab9, which mediates late-endosome-to-trans-Golgi-network trafficking, among several candidate host genes whose ..
  8. Chen L, DiGiammarino E, Zhou X, Wang Y, Toh D, Hodge T, et al. High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target. J Biol Chem. 2004;279:40204-8 pubmed
    ..b>Rab9 mediates late endosome to trans-Golgi transport and has recently been found to be a key cellular component for ..
  9. Ohishi Y, Kinoshita R, Marubashi S, Ishida M, Fukuda M. The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis. J Biol Chem. 2019;294:6912-6922 pubmed publisher
    ..factor (GEF) for RAB32, a member of the Rab small GTPase family (Rab32), and Rab38 (Rab32/38-GEF) and also as a Rab9 effector...

More Information

Publications79

  1. Shimizu S, Arakawa S, Nishida Y. Autophagy takes an alternative pathway. Autophagy. 2010;6:290-1 pubmed
    ..Unlike conventional macroautophagy, autophagosomes seemed to be generated in a Rab9-dependent manner by the fusion of the phagophore with vesicles derived from the trans-Golgi and late endosomes...
  2. Snyder J, Rochelle L, Lyerly H, Caron M, BARAK L. Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J Biol Chem. 2013;288:10286-97 pubmed publisher
    ..Rather, internalized LGR5 transits through Rab7- and Rab9-positive vesicles, co-localizes in vesicles with Vps26, a retromer complex component that regulates retrograde ..
  3. Seixas E, Escrevente C, Seabra M, Barral D. Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression. Sci Rep. 2018;8:12998 pubmed publisher
    ..Plasmodium berghei and the bacterium Escherichia coli subvert phagocytosis through the modulation of Rab14 or Rab9a expression, respectively...
  4. Martínez Morales J, Romero Avila M, Reyes Cruz G, García Sáinz J. S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine. Biosci Rep. 2018;38: pubmed publisher
    ..S1P1 receptor-Rab9 interaction was mainly increased by the phorbol ester, whereas S1P1 receptor-Rab7 interaction was only ..
  5. Hirota Y, Yamashita S, Kurihara Y, Jin X, Aihara M, Saigusa T, et al. Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways. Autophagy. 2015;11:332-43 pubmed publisher
    ..However, knockdown of RAB9A and RAB9B, which are essential for alternative autophagy, but not conventional macroautophagy, severely suppressed ..
  6. McGourty K, Thurston T, Matthews S, Pinaud L, Mota L, Holden D. Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function. Science. 2012;338:963-7 pubmed publisher
    ..We found that the effector SifA subverted Rab9-dependent retrograde trafficking of MPRs, thereby attenuating lysosome function...
  7. Prokšová P, Lipov J, Zelenka J, Hunter E, Langerová H, Rumlova M, et al. Mason-Pfizer Monkey Virus Envelope Glycoprotein Cycling and Its Vesicular Co-Transport with Immature Particles. Viruses. 2018;10: pubmed publisher
    ..Using a panel of labeled RabGTPases as endosomal markers, we identified Env mostly in Rab7a- and Rab9a-positive endosomes...
  8. Lai C, Kuo C, Chiang S, Pai P, Lin J, Chang C, et al. Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure. J Mol Cell Cardiol. 2018;122:58-68 pubmed publisher
    ..Moreover, IGF-IIR signaling triggered Rab9-dependent autophagosome formation by the JNK-mediated phosphorylation of Bcl-2 at serine 87 and promoted ULK1/..
  9. Hayes G, Brown F, Haas A, Nottingham R, Barr F, Pfeffer S. Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi. Mol Biol Cell. 2009;20:209-17 pubmed publisher
    GCC185, a trans-Golgi network-localized protein predicted to assume a long, coiled-coil structure, is required for Rab9-dependent recycling of mannose 6-phosphate receptors (MPRs) to the Golgi and for microtubule nucleation at the Golgi ..
  10. Dodson M, Leung L, Lone M, Lizzio M, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis Model Mech. 2014;7:1351-63 pubmed publisher
    ..lysosomal abnormalities in these lrrk mutants can be suppressed by a constitutively active form of the small GTPase rab9, which promotes retromer-dependent recycling from late endosomes to the Golgi...
  11. Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 2008;19:5360-72 pubmed publisher
    ..Although Atg14 is present on autophagic isolation membranes, UVRAG primarily associates with Rab9-positive endosomes. Silencing of human Atg14 in HeLa cells suppresses autophagosome formation...
  12. Zhang Y, Liu Y, Xiao F, Liu C, Liang X, Chen J, et al. Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages. J Virol. 2018;92: pubmed publisher
    ..The results showed that Rab5, Rab7, and Rab11, but not Rab9, regulate CSFV endocytosis...
  13. Dong B, Miao G, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development. 2014;141:4104-9 pubmed publisher
    ..This process was defective in rab9 and shrub/vps32 mutants and in wild-type embryos treated with a secretory pathway inhibitor, leading to an abundant ..
  14. Zhang Z, Wang S, Shen T, Chen J, Ding J. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Structure. 2014;22:1408-20 pubmed publisher
    ..Here, we report the crystal structure of GTP-bound Rab9A in complex with the Rab-binding domain (RBD) of the effector RUTBC2...
  15. Shubin A, Demidyuk I, Lunina N, Komissarov A, Roschina M, Leonova O, et al. Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death. BMC Cell Biol. 2015;16:4 pubmed publisher
    ..The lysosomal protein Lamp1 and GTPases Rab5, Rab7, Rab9, and Rab11 were associated with the vacuolar membranes...
  16. Gillingham A, Sinka R, Torres I, Lilley K, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358-73 pubmed publisher
    ..We confirm over 25 interactions for Rab2, Rab4, Rab5, Rab6, Rab7, Rab9, Rab18, Rab19, Rab30, and Rab39...
  17. Chichger H, Braza J, Duong H, Boni G, Harrington E. Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin. Am J Respir Cell Mol Biol. 2016;54:769-81 pubmed publisher
    ..Our study demonstrates a key role for Rab4 activation and Rab9 inhibition in regulation of vascular permeability through enhanced VE-cadherin expression at the interendothelial ..
  18. Muhammad E, Levitas A, Singh S, Braiman A, Ofir R, Etzion S, et al. PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction. Hum Mol Genet. 2015;24:7227-40 pubmed publisher
    ..patients' primary fibroblasts exhibited abnormal subcellular distribution of endosomes marked by Rab5, Rab7 and Rab9, as well as the Golgi apparatus...
  19. Banerjee S, Bose D, Chatterjee N, Das S, Chakraborty S, Das T, et al. Attenuated Leishmania induce pro-inflammatory mediators and influence leishmanicidal activity by p38 MAPK dependent phagosome maturation in Leishmania donovani co-infected macrophages. Sci Rep. 2016;6:22335 pubmed publisher
    ..donovani and late phagosomal markers viz. Rab7, Lysosomal Associated Membrane Protein 1, Cathepsin D, Rab9, and V-ATPase which indicate phagosome maturation...
  20. Cao Y, Zhang S, Yuan N, Wang J, Li X, Xu F, et al. Hierarchal Autophagic Divergence of Hematopoietic System. J Biol Chem. 2015;290:23050-63 pubmed publisher
    ..Removing Rab9, a key regulatory protein, in alternative autophagy, disables autophagy altogether in Atg7-deficient macrophages...
  21. Charfi I, Abdallah K, Gendron L, Pineyro G. Delta opioid receptors recycle to the membrane after sorting to the degradation path. Cell Mol Life Sci. 2018;75:2257-2271 pubmed publisher
    ..The LE sorting mechanism involved ESCRT accessory protein Alix and the TIP47/Rab9 retrieval complex which supported translocation of the receptor to the TGN, from where it subsequently regained the ..
  22. Shrestha B, Karki H, Groth D, Jungkhun N, Ham J. Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice. PLoS ONE. 2016;11:e0146764 pubmed publisher
    ..The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B. amyloliquefaciens in DNA sequence of 16S rDNA and gyrB, but to B...
  23. Matheoud D, Sugiura A, Bellemare Pelletier A, Laplante A, Rondeau C, Chemali M, et al. Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation. Cell. 2016;166:314-327 pubmed publisher
    ..MitAP and the formation of MDVs require Rab9 and Sorting nexin 9, whose recruitment to mitochondria is inhibited by Parkin...
  24. Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
    ..is vital in neovascularization, we sought to elucidate the role for endosome proteins p18 and Rab4, Rab7, and Rab9 in the process of vessel formation within the pulmonary vasculature...
  25. Cardoso R, Wang J, Müller J, Rupp S, Leitão A, Hemphill A. Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Exp Parasitol. 2018;187:75-85 pubmed publisher
    ..The localization of Rab9A, an important regulator of endosomal trafficking, was also studied...
  26. Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016;291:1427-40 pubmed publisher
    ..The results of this study also demonstrated the involvement of Rab9A in the regulation of the RUTBC1 localization and in the trafficking of all three melanogenic enzymes...
  27. Zhu Y, Zheng M, Song D, Ye L, Wang X. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015;13:318 pubmed publisher
    ..and 23 down-regulated (Abcb7, Atf1, Ddx26b, Drp2, Fam122b, Gyk, Irak1, Lamp2, Mecp2, Ndufb11, Ogt, Pdha1, Pola1, Rab9, Rbmx2, Rhox9, Thoc2, Vbp1, Dkc1, Nkrf, Piga, Tmlhe and Tsr2), as compared with other cells...
  28. Dinter E, Saridaki T, Nippold M, Plum S, Diederichs L, Komnig D, et al. Rab7 induces clearance of ?-synuclein aggregates. J Neurochem. 2016;138:758-74 pubmed publisher
    ..not produced by Rab7 missense mutations causing Charcot Marie Tooth neuropathy, or by the related GTPases Rab5, Rab9, or Rab23...
  29. Bayer K, Banning C, Bruss V, Wiltzer Bach L, Schindler M. Hepatitis C Virus Is Released via a Noncanonical Secretory Route. J Virol. 2016;90:10558-10573 pubmed publisher
    ..In contrast, HCV-E1-mCherry trafficked with Rab9-positive compartments and inhibition of endosomes specifically suppressed HCV release...
  30. Tam J, Pasternak S. Imaging the Intracellular Trafficking of APP with Photoactivatable GFP. J Vis Exp. 2015;:e53153 pubmed publisher
    ..identified with fluorescently tagged compartment marker proteins for the early endosome (Rab5), the late endosome (Rab9) and the lysosome (LAMP1)...
  31. Zafar S, Younas N, Correia S, Shafiq M, Tahir W, Schmitz M, et al. Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease. Mol Neurobiol. 2017;54:697-709 pubmed publisher
    ..However, Rab9 expression was significantly downregulated only in CJD-MM1 brain frontal cortex region...
  32. Michel F, Soler Lopez M, Petosa C, Cramer P, Siebenlist U, Muller C. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J. 2001;20:6180-90 pubmed
    ..Comparison of the two structures thus provides an insight into the functional diversity of IkappaB proteins. ..
  33. Chen Y, Honeychurch K, Yang G, Byrd C, Harver C, Hruby D, et al. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virol J. 2009;6:44 pubmed publisher
    ..LE-derived transport vesicles form through the interaction of Rab9 GTPase with cargo proteins, and TIP47, a Rab9-specific effector protein...
  34. Podhajska A, Musso A, Trancikova A, Stafa K, Moser R, Sonnay S, et al. Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism. PLoS ONE. 2012;7:e39942 pubmed publisher
    ..Collectively, our study provides support for common loss-of-function effects of homozygous and heterozygous missense mutations in ATP13A2 associated with early-onset forms of parkinsonism. ..
  35. Arakawa S, Honda S, Yamaguchi H, Shimizu S. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:378-385 pubmed publisher
    ..Unlike conventional autophagy, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of the phagophores with vesicles derived from the trans-Golgi and late endosomes...
  36. Burguete A, Fenn T, Brunger A, Pfeffer S. Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185. Cell. 2008;132:286-98 pubmed publisher
  37. Day P, Thompson C, Schowalter R, Lowy D, Schiller J. Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection. J Virol. 2013;87:3862-70 pubmed publisher
    ..Additionally, Rab9a and Rab7b were determined to be mediators of this transit, as expression of dominant negative versions of these ..
  38. Orzaez D, de Jong A, Woltering E. A tomato homologue of the human protein PIRIN is induced during programmed cell death. Plant Mol Biol. 2001;46:459-68 pubmed
    ..The isolation of Le-pirin and its implication in plant PCD provides new clues on the role of putative NF-kappaB-associated pathways in plant defence mechanisms. ..
  39. Espinosa E, Calero M, Sridevi K, Pfeffer S. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Cell. 2009;137:938-48 pubmed publisher
    ..We report here that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network...
  40. Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011;12:407-20 pubmed publisher
    ..tb-containing phagosomes is involved in arresting phagosome maturation and inhibiting phagolysosome biogenesis. ..
  41. Ploen D, Hafirassou M, Himmelsbach K, Schille S, Biniossek M, Baumert T, et al. TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles. Eur J Cell Biol. 2013;92:374-82 pubmed publisher
    ..Silencing of the TIP47 binding partner Rab9 by lentiviral transduction abolishes the viral replication...
  42. Seaman M. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol. 2004;165:111-22 pubmed
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin. ..
  43. Walter M, Chen F, Tamari F, Wang R, Ioannou Y. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. Biol Cell. 2009;101:141-52 pubmed publisher
    ..We have previously demonstrated that expression of the small GTPase Rab9 in NPC1 cells can rescue the lipid transport block phenotype (Walter et al...
  44. Mahanty S, Ravichandran K, Chitirala P, Prabha J, Jani R, Setty S. Rab9A is required for delivery of cargo from recycling endosomes to melanosomes. Pigment Cell Melanoma Res. 2016;29:43-59 pubmed publisher
    ..Although several Rab GTPases have been shown to regulate these trafficking steps, the precise role of Rab9A remains unknown...
  45. Walter M, Davies J, Ioannou Y. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. J Lipid Res. 2003;44:243-53 pubmed
    ..of human telomerase reverse transcriptase (hTeRT) in human cells leads to an upregulation of the small GTPase Rab9 and its effector p40...
  46. Maryon E, Zhang J, Jellison J, Kaplan J. Human copper transporter 1 lacking O-linked glycosylation is proteolytically cleaved in a Rab9-positive endosomal compartment. J Biol Chem. 2009;284:28104-14 pubmed publisher
    ..These puncta overlap compartments were stained by Rab9, indicating that hCTR1 cleavage occurs in a late endosomal compartment prior to delivery of the transporter to the ..
  47. Kadiu I, Gendelman H. Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network. J Proteome Res. 2011;10:3225-38 pubmed publisher
    ..Sequestered infectious viral components targeted the Golgi and ER by retrograde transport from early and Rab9 late endosomes. Disruption of the ER-Golgi network impaired HIV-1 trafficking in the conduit endosomes...
  48. Burguete A, Harbury P, Pfeffer S. In vitro selection and prediction of TIP47 protein-interaction interfaces. Nat Methods. 2004;1:55-60 pubmed
    ..Tail-interacting protein of 47 kDa (TIP47) binds Rab9 GTPase and the cytoplasmic domains of mannose 6-phosphate receptors and is required for their transport from ..
  49. Milev M, Brown C, Mouland A. Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. Retrovirology. 2010;7:41 pubmed publisher
    ..The present work characterizes the interaction sites of key components of the HIV-1 RNP (Gag, Staufen1 and IMP1), thereby bringing to light where HIV-1 recruits and co-opts RNA-binding proteins during virus assembly. ..
  50. Kloer D, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, et al. Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem. 2010;285:7794-804 pubmed publisher
    ..screen reveals a specific and strong interaction of BLOC-3 with the GTP-bound form of the endosomal GTPase, Rab9. This interaction is mediated by HPS4 and the switch I and II regions of Rab9...
  51. Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12:19-30; sup pp 1-13 pubmed publisher
    ..Our results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo. ..
  52. Alfonzo Méndez M, Hernández Espinosa D, Carmona Rosas G, Romero Ávila M, Reyes Cruz G, García Sáinz J. Protein Kinase C Activation Promotes α1B-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization. Mol Pharmacol. 2017;91:296-306 pubmed publisher
    ..However, the fine mechanisms that participate remain unsolved. The roles of protein kinase C and the small GTPase, Rab9, in α1B-AR vesicular traffic were investigated by studying α1B-adrenergic ..
  53. Shapiro A, Pfeffer S. Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides. J Biol Chem. 1995;270:11085-90 pubmed
    b>Rab9 is a Ras-like GTPase required for the transport of mannose 6-phosphate receptors between late endosomes and the trans Golgi network...
  54. Kumar M, Kaur S, Nazir A, Tripathi R. HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling. Biochem Biophys Res Commun. 2016;474:137-145 pubmed publisher
    ..GCC185 is a tethering protein that binds with Rab9 transport vesicles...
  55. Davies J, Cotter P, Ioannou Y. Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. Genomics. 1997;41:131-4 pubmed
    ..studies of the mechanism of lysosomal integral membrane protein (LAMP-1) transport, cDNAs for human Rab7 and Rab9 were isolated, and their nucleotide sequences were determined...
  56. Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Cell Microbiol. 2012;14:1149-65 pubmed publisher
    ..Here we identified the small GTPases Rab9A and Rab23 as novel autophagy regulators during Group A streptococcus (GAS) infection...
  57. Correia M, Moreiras H, Pereira F, Neto M, Festas T, Tarafder A, et al. Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments. J Invest Dermatol. 2018;138:637-646 pubmed publisher
    ..we found that the silencing of the early endocytic regulator Rab5b, but not the late endocytic regulators Rab7a or Rab9a, significantly impairs melanocore uptake by keratinocytes...
  58. Barbero P, Bittova L, Pfeffer S. Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells. J Cell Biol. 2002;156:511-8 pubmed
    ..receptors (MPRs) are transported from endosomes to the trans-Golgi via a transport process that requires the Rab9 GTPase and the cargo adaptor TIP47...
  59. Cayouette S, Bousquet S, Francoeur N, Dupré E, Monet M, Gagnon H, et al. Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6. Biochim Biophys Acta. 2010;1803:805-12 pubmed publisher
    ..In the present study, we highlighted the involvement of two Rab GTPases in the trafficking of TRPC6. Rab9 co-localized in vesicular structures with TRPC6 in HeLa cells and co-immunoprecipitated with TRPC6...
  60. Nottingham R, Pusapati G, Ganley I, Barr F, Lambright D, Pfeffer S. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J Biol Chem. 2012;287:22740-8 pubmed publisher
    ..b>Rab9A and its effectors regulate recycling of mannose 6-phosphate receptors from late endosomes to the trans Golgi ..
  61. Aivazian D, Serrano R, Pfeffer S. TIP47 is a key effector for Rab9 localization. J Cell Biol. 2006;173:917-26 pubmed
    ..Two chimeras could bind effectors for two distinctly localized Rabs; a Rab5/9 hybrid bound both Rab5 and Rab9 effectors, and a Rab1/9 hybrid bound to certain Rab1 and Rab9 effectors...
  62. de Leeuw H, Koster P, Calafat J, Janssen H, van Zonneveld A, Van Mourik J, et al. Small GTP-binding proteins in human endothelial cells. Br J Haematol. 1998;103:15-9 pubmed
    ..Two sequences corresponded to novel isoforms of Rab2 and Rab9. In addition, human analogues of Rab4b, Rab7, Rab9, Rab14 and Rab15 were identified...
  63. Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y. Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in ?-Amyloid Precursor Protein Metabolism. Am J Pathol. 2016;186:1952-1966 pubmed publisher
    ..Moreover, we found that knockdown of Rab7, Rab9, or Rab11 did not alter endogenous APP metabolism, such as that observed in aged monkey brains and in dynein-..
  64. Nottingham R, Ganley I, Barr F, Lambright D, Pfeffer S. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. J Biol Chem. 2011;286:33213-22 pubmed publisher
    ..The substrates for most Rab GTPase-activating proteins (GAPs) are unknown. Rab9A and its effectors regulate transport of mannose 6-phosphate receptors from late endosomes to the trans-Golgi ..
  65. Jackson L, Nawabi P, Hentea C, Roark E, Haldar K. The Salmonella virulence protein SifA is a G protein antagonist. Proc Natl Acad Sci U S A. 2008;105:14141-6 pubmed publisher
    ..We show that SKIP's pleckstrin homology domain, which directly binds SifA, also binds to the late endosomal GTPase Rab9. Knockdown studies suggest that both SKIP and Rab9 function to maintain peripheral LAMP1 distribution in cells...
  66. Kuijl C, Pilli M, Alahari S, Janssen H, Khoo P, Ervin K, et al. Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria. EMBO J. 2013;32:713-27 pubmed publisher
    ..identify Nischarin as a novel dual effector that can interact with members of Rac and Rab GTPase (Rab4, Rab14 and Rab9) families at different endosomal compartments...
  67. Liu C, Zhang Y, Li Z, Hou J, Zhou J, Kan L, et al. Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells. J Virol. 2017;91: pubmed publisher
    ..Expression of DN Rab5 and DN Rab11, but not DN Rab7 and DN Rab9, significantly inhibited JEV replication...
  68. Dziuba N, Ferguson M, O Brien W, Sanchez A, Prussia A, McDonald N, et al. Identification of cellular proteins required for replication of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 2012;28:1329-39 pubmed
    ..However, the genes presented in this study did not share identity with those found previously. Novel antiviral targets identified in this study should open new avenues for mechanistic investigation. ..
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