RAB6A

Summary

Gene Symbol: RAB6A
Description: RAB6A, member RAS oncogene family
Alias: RAB6, ras-related protein Rab-6A, RAB6, member RAS oncogene family, Rab GTPase
Species: human
Products:     RAB6A

Top Publications

  1. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr F. The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. Curr Biol. 2002;12:1792-5 pubmed
    ..Other Rabs have been implicated in microtubule-dependent organelle motility; Rab7 controls lysosomal transport, and Rab6 is involved in microtubule-dependent transport pathways through the Golgi and from endosomes to the Golgi...
  2. Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J. 2006;25:3750-61 pubmed
    ..Strongest interaction is seen with Golgi-associated rab1 and rab6 and endosomal rab5...
  3. Grigoriev I, Splinter D, Keijzer N, Wulf P, Demmers J, Ohtsuka T, et al. Rab6 regulates transport and targeting of exocytotic carriers. Dev Cell. 2007;13:305-14 pubmed
    ..Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their ..
  4. Goud B, Zahraoui A, Tavitian A, Saraste J. Small GTP-binding protein associated with Golgi cisternae. Nature. 1990;345:553-6 pubmed
    ..By immunolabelling and electron microscopy, Rab6p appears to be concentrated predominantly on the medial and trans cisternae and distributed over their entire surface. ..
  5. Janoueix Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem. 1995;270:14801-8 pubmed
    b>Rab6 is a small GTP-binding protein that belongs to the Ras superfamily and is involved in intra-Golgi transport...
  6. Cuif M, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel Courteille A, et al. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 1999;18:1772-82 pubmed
    ..indicates that GAPCenA displays similarities, within a central 200 amino acids domain, to both the yeast Rab GTPase activating proteins (GAPs) and to the spindle checkpoint proteins Saccharomyces cerevisiae Bub2p and ..
  7. Echard A, Opdam F, de Leeuw H, Jollivet F, Savelkoul P, Hendriks W, et al. Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. Mol Biol Cell. 2000;11:3819-33 pubmed
    Analysis of the human Rab6A gene structure reveals the presence of a duplicated exon, and incorporation of either of the two exons by alternative splicing is shown to generate two Rab6 isoforms named Rab6A and Rab6A', which differ in ..
  8. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T. Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. FEBS Lett. 2001;508:201-9 pubmed
    ..A similar binding was seen to rab1 but not to rab6, both Golgi rabs...
  9. Monier S, Jollivet F, Janoueix Lerosey I, Johannes L, Goud B. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Traffic. 2002;3:289-97 pubmed
    ..we have isolated two clones that specifically interact with the three isoforms of Rab6 present in mammalian cells (Rab6A, A' and B)...

More Information

Publications117 found, 100 shown here

  1. Matanis T, Akhmanova A, Wulf P, del Nery E, Weide T, Stepanova T, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002;4:986-92 pubmed
    The small GTPase Rab6a is involved in the regulation of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) in a coat complex coatomer protein I (COPI)-independent pathway...
  2. Nizak C, Monier S, del Nery E, Moutel S, Goud B, Perez F. Recombinant antibodies to the small GTPase Rab6 as conformation sensors. Science. 2003;300:984-7 pubmed
    ..specific to the guanosine triphosphate (GTP)-bound conformation of the small guanosine triphosphatase (GTPase) Rab6, a regulator of membrane traffic, were generated and used to locate Rab6...
  3. Young J, Stauber T, del Nery E, Vernos I, Pepperkok R, Nilsson T. Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'. Mol Biol Cell. 2005;16:162-77 pubmed
    The small GTPase rab6A but not the isoform rab6A' has previously been identified as a regulator of the COPI-independent recycling route that carries Golgi-resident proteins and certain toxins from the Golgi to the endoplasmic reticulum (..
  4. del Nery E, Miserey Lenkei S, Falguières T, Nizak C, Johannes L, Perez F, et al. Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking. Traffic. 2006;7:394-407 pubmed
    The closely related Rab6 isoforms, Rab6A and Rab6A', have been shown to regulate vesicular trafficking within the Golgi and post-Golgi compartments, but studies using dominant active or negative mutant suggested conflicting models...
  5. Splinter D, Tanenbaum M, Lindqvist A, Jaarsma D, Flotho A, Yu K, et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 2010;8:e1000350 pubmed publisher
  6. Miserey Lenkei S, Chalancon G, Bardin S, Formstecher E, Goud B, Echard A. Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex. Nat Cell Biol. 2010;12:645-54 pubmed publisher
    ..Here we show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, ..
  7. Grigoriev I, Yu K, Martinez Sanchez E, Serra Marques A, Smal I, Meijering E, et al. Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. Curr Biol. 2011;21:967-74 pubmed publisher
    b>Rab6 is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers [1]...
  8. Elfrink H, Zwart R, Cavanillas M, Schindler A, Baas F, Scheper W. Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease. J Alzheimers Dis. 2012;28:917-29 pubmed publisher
    ..We found that the level of Rab6, implicated in anterograde and retrograde trafficking in the secretory pathway, is increased in brains of AD ..
  9. Wang C, Saar V, Leung K, Chen L, Wong G. Human amyloid ? peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiol Dis. 2018;109:88-101 pubmed publisher
    ..to the top 60 genes related to human AD confirmed an overlap of 8 genes: patched homolog 1, PTCH1 (ptc-3), the Rab GTPase activating protein, TBC1D16 (tbc-16), the WD repeat and FYVE domain-containing protein 3, WDFY3 (wdfy-3), ADP-..
  10. Balasubramaniam S, Riley L, Bratkovic D, Ketteridge D, Manton N, Cowley M, et al. Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency. J Inherit Metab Dis. 2017;40:745-747 pubmed publisher
    ..by mutations in the transaldolase 1 (TALDO1) gene; Gerodermia osteodysplastica due to mutations in the golgin, RAB6-interacting (GORAB or SCYL1BP1) gene; and mitogen-activated pathway (MAP) kinase defects, caused by mutations in ..
  11. Hass H, Vogel U, Scheurlen M, Jobst J. Gene-expression Analysis Identifies Specific Patterns of Dysregulated Molecular Pathways and Genetic Subgroups of Human Hepatocellular Carcinoma. Anticancer Res. 2016;36:5087-5095 pubmed
    ..g. Rac GTPase activating protein 1 (RACGAP1), Rab GTPase YPT1 homolog (RAB1), and ADP-ribosylation factor-like 2 (ARL2)] and extracellular matrix re-modelling or ..
  12. He W, Rahimnejad S, Wang L, Song K, Lu K, Zhang C. Effects of organic acids and essential oils blend on growth, gut microbiota, immune response and disease resistance of Pacific white shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus. Fish Shellfish Immunol. 2017;70:164-173 pubmed publisher
    ..Expression of gut pro-inflammatory genes including TNF-?, LITAF and RAB6A were down-regulated by AP administration...
  13. Qadir F, Aziz M, Sari C, Ma H, Dai H, Wang X, et al. Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Mol Cancer. 2018;17:97 pubmed publisher
    ..IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), lipid metabolism and membrane trafficking (BBOX1, LRP11, RAB6A)...
  14. Hanadate Y, Saito Nakano Y, Nakada Tsukui K, Nozaki T. Endoplasmic reticulum-resident Rab8A GTPase is involved in phagocytosis in the protozoan parasite Entamoeba histolytica. Cell Microbiol. 2016;18:1358-73 pubmed publisher
    ..To our knowledge, this is the first report that the ER-resident Rab GTPase is involved in phagocytosis through the regulation of trafficking of a surface receptor, supporting a premise of ..
  15. Guerrieri F, Belloni L, D Andrea D, Pediconi N, Le Pera L, Testoni B, et al. Genome-wide identification of direct HBx genomic targets. BMC Genomics. 2017;18:184 pubmed publisher
  16. Minamino N, Kanazawa T, Nishihama R, Yamato K, Ishizaki K, Kohchi T, et al. Dynamic reorganization of the endomembrane system during spermatogenesis in Marchantia polymorpha. J Plant Res. 2017;130:433-441 pubmed publisher
    ..changes in subcellular localization were also observed for other fluorescently tagged SNARE proteins and a RAB GTPase, which acts on other organelles including the Golgi apparatus and endosomes...
  17. Rossor A, Oates E, Salter H, Liu Y, Murphy S, Schule R, et al. Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2. Brain. 2015;138:293-310 pubmed publisher
    ..Glu774Gly substitution inhibits the binding of BICD2 to Rab6. Overall, the features of BICD2 spinal muscular atrophy, lower extremity predominant are consistent with a ..
  18. Skrypek N, Bruneel K, Vandewalle C, De Smedt E, Soen B, Loret N, et al. ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition. Epigenetics Chromatin. 2018;11:70 pubmed publisher
    ..study, we aimed to characterize the epigenetic effect of ZEB2 repressive function on the regulation of a small Rab GTPase RAB25...
  19. Jensch A, Frey Y, Bitschar K, Weber P, Schmid S, Hausser A, et al. The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function. J Biol Chem. 2018;293:14407-14416 pubmed publisher
    ..of the cargo protein horseradish peroxidase, and was associated with the accumulation of the small GTPase RAB6 on Golgi membranes, indicating a protein-trafficking defect...
  20. Brewer P, Habtemichael E, Romenskaia I, Coster A, Mastick C. Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes. Biochem J. 2016;473:1315-27 pubmed publisher
    ..This hypothesis is consistent with known Rab14 effectors. Interestingly, the insulin-sensitive Rab GTPase-activating protein Akt substrate of 160 kDa (AS160) affects both sorting into and exocytosis from GSVs...
  21. Greninger A, Knudsen G, Betegon M, Burlingame A, Derisi J. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. MBio. 2013;4:e00098-13 pubmed publisher
    ..We identify a new binding partner of ACBD3 in the evolutionarily conserved Rab GTPase-activating proteins (RabGAPs) TBC1D22A and -B...
  22. Ke C, Lin Y, Wang Y, Wu Y, Chen M, Ku W, et al. TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>TBC1D21 genes (also known as male germ cell RAB GTPase-activating protein MGCRABGAP) are related to sterility, as determined through cDNA microarray testing of human ..
  23. Roos J, Bejai S, Oide S, Dixelius C. RabGAP22 is required for defense to the vascular pathogen Verticillium longisporum and contributes to stomata immunity. PLoS ONE. 2014;9:e88187 pubmed publisher
    ..Here, we report on the identification and characterization of the Rab GTPase-activating protein RabGAP22 gene from Arabidopsis, as an activator of multiple components in the immune ..
  24. Mousnier A, Schroeder G, Stoneham C, So E, Garnett J, Yu L, et al. A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases. MBio. 2014;5: pubmed publisher
    ..which is widely applicable to other pathogens, we identified PieE as a multidomain LCV protein with promiscuous Rab GTPase-binding capacity...
  25. Lu X, Luan S, Dai P, Meng X, Cao B, Luo K, et al. iTRAQ-based comparative proteome analysis for molecular mechanism of defense against acute ammonia toxicity in Pacific White shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2018;74:52-61 pubmed publisher
    ..reported mainly involving in immune defense and stress tolerant in crustacean species, such as hemocyanin, Rab7, Rab GTPase, Rac1, alpha 2 macroglobulin, Bip, peroxiredoxin, Cu/Zn SOD, glutathione peroxidase, thioredoxin, calreticulin, ..
  26. Kurischko C, Kuravi V, Wannissorn N, Nazarov P, Husain M, Zhang C, et al. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell. 2008;19:5559-78 pubmed publisher
    ..These data suggest that an important function for Cbk1 and the RAM signaling network is to regulate growth and secretion via Golgi and Sec2/Sec4-dependent processes. ..
  27. Ren C, Chen T, Jiang X, Wang Y, Hu C. The first characterization of gene structure and biological function for echinoderm translationally controlled tumor protein (TCTP). Fish Shellfish Immunol. 2014;41:137-46 pubmed publisher
    ..termed TCTP1 and TCTP2, a microtubule binding domain, a Ca(2+) binding domain and the conserved residues forming Rab GTPase binding surface were found in the StmTCTP amino acid sequence...
  28. Uno T, Furutani M, Watanabe C, Sakamoto K, Uno Y, Kanamaru K, et al. Rab proteins in the brain and corpus allatum of Bombyx mori. Histochem Cell Biol. 2016;146:59-69 pubmed publisher
    ..Rab3, Rab6, and Rab27 control the regulatory secretory pathway of neuropeptides and neurotransmitters...
  29. Srikanth S, Kim K, Gao Y, Woo J, Ghosh S, Calmettes G, et al. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016;9:ra31 pubmed publisher
    ..We showed thatCRACR2A(Ca(2+) release-activated Ca(2+) channel regulator 2A) encodes a lymphocyte-specific large Rab GTPase that contains multiple functional domains, including EF-hand motifs, a proline-rich domain (PRD), and a Rab ..
  30. Patwardhan A, Bardin S, Miserey Lenkei S, Larue L, Goud B, Raposo G, et al. Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes. Nat Commun. 2017;8:15835 pubmed publisher
    ..While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking of secretory vesicles to particular areas of the plasma ..
  31. Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, et al. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS ONE. 2013;8:e64149 pubmed publisher
    ..They have been shown to play a role in several human diseases. One prominent member, Rab6, is thought to be involved in the development of Alzheimer's Disease, the most prevalent mental disorder worldwide...
  32. Egerer J, Emmerich D, Fischer Zirnsak B, Chan W, Meierhofer D, Tuysuz B, et al. GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting. J Invest Dermatol. 2015;135:2368-2376 pubmed publisher
    ..The golgin, RAB6-interacting (GORAB) protein localizes to the Golgi apparatus and interacts with the small GTPase RAB6...
  33. Sunada M, Goh T, Ueda T, Nakano A. Functional analyses of the plant-specific C-terminal region of VPS9a: the activating factor for RAB5 in Arabidopsis thaliana. J Plant Res. 2016;129:93-102 pubmed publisher
    Recent studies demonstrated that endosomal transport played important roles in various plant functions. The RAB GTPase regulates the tethering and fusion steps of vesicle trafficking to target membranes in each trafficking pathway by ..
  34. Iwanami N, Nakamura Y, Satoh T, Liu Z, Satoh A. Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors. PLoS Genet. 2016;12:e1005828 pubmed publisher
    ..using whole-genome resequencing and single nucleotide polymorphism mapping identified a nonsense mutation of Rab6 responsible for the apical-specific transport deficiency...
  35. Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher
    ..In addition, our study reveals for the first time that the ubiquitin-proteasome degradation pathway regulates a Rab GTPase. Rab35 is required for axonal outgrowth...
  36. Zick M, Wickner W. Improved reconstitution of yeast vacuole fusion with physiological SNARE concentrations reveals an asymmetric Rab(GTP) requirement. Mol Biol Cell. 2016;27:2590-7 pubmed publisher
    ..2) Substantial lysis accompanies reconstituted fusion. 3) The Rab GTPase Ypt7 is essential in vivo but often dispensable in vitro...
  37. Galea G, Bexiga M, Panarella A, O Neill E, Simpson J. A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. J Cell Sci. 2015;128:2339-49 pubmed publisher
    ..Systematic RNA interference (RNAi)-based depletion of 58 Rab GTPase proteins and 12 Rab accessory proteins of the PRAF, YIPF and YIF protein families revealed that nine of these ..
  38. Allen C, Kortagere S, Tong H, Matthiesen R, Metzger J, Wiemer D, et al. Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase. Mol Pharmacol. 2017;91:229-236 pubmed publisher
    ..is of interest from a therapeutic perspective for multiple myeloma because we have shown that targeting Rab GTPase geranylgeranylation impairs monoclonal protein trafficking, leading to endoplasmic reticulum stress and ..
  39. Pfeffer S. Rab GTPases: master regulators that establish the secretory and endocytic pathways. Mol Biol Cell. 2017;28:712-715 pubmed publisher
    ..by the biomedical research community and are highlighted here, along with open questions that require serious attention for full understanding of the molecular basis of Rab GTPase-regulated membrane trafficking in eukaryotic cells.
  40. Shin J, Gillingham A, Begum F, Chadwick J, Munro S. TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. Nat Cell Biol. 2017;19:1424-1432 pubmed publisher
    ..to the golgin-captured vesicles, we identify TBC1D23, an apparently catalytically inactive member of a family of Rab GTPase-activating proteins (GAPs), as a vesicle-golgin adaptor that is required for endosome-to-Golgi trafficking...
  41. Riedel F, Galindo A, Muschalik N, Munro S. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. J Cell Biol. 2018;217:601-617 pubmed publisher
    Originally identified in yeast, transport protein particle (TRAPP) complexes are Rab GTPase exchange factors that share a core set of subunits...
  42. Pantazopoulou A. The Golgi apparatus: insights from filamentous fungi. Mycologia. 2016;108:603-22 pubmed publisher
    ..Golgi biology has yielded so far regarding our understanding of key Golgi regulators, such as the Rab GTPases RabC(Rab6) and RabE(Rab11), the oligomeric transport protein particle, TRAPPII, and the Golgi guanine nucleotide exchange ..
  43. Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, et al. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nat Commun. 2017;8:14646 pubmed publisher
    The Rab GTPase effector, Rab-coupling protein (RCP) is known to promote invasive behaviour in vitro by controlling integrin and receptor tyrosine kinase (RTK) trafficking, but how RCP influences metastasis in vivo is unclear...
  44. Li Y, Wang Y, Zou L, Tang X, Yang Y, Ma L, et al. Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. Immunity. 2016;44:422-37 pubmed publisher
    ..strategy and mass spectrometry, we depicted an interactomic landscape of major members of the mammalian Rab GTPase family...
  45. Mohamed N, Desjardins A, Leclerc N. Tau secretion is correlated to an increase of Golgi dynamics. PLoS ONE. 2017;12:e0178288 pubmed publisher
    ..The suppression of Rab1A, Rab GTPase associated with the Golgi membranes, known to induce a Golgi fragmentation increased Tau secretion by both ..
  46. Jewett C, Vanderleest T, Miao H, Xie Y, Madhu R, Loerke D, et al. Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium. Nat Commun. 2017;8:476 pubmed publisher
    ..Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure ..
  47. Kuroda T, Fukuda M, Ariga H, Mikoshiba K. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun. 2002;293:899-906 pubmed
    ..members, the SHD of Slp5 preferentially interacted with the GTP-bound form of Rab27A and marginally with Rab3A and Rab6A, both in vitro and in intact cells, but not with other Rabs tested (Rab1, Rab2, Rab4A, Rab5A, Rab7, Rab8, Rab9, ..
  48. Li H, Yu P, Sun Y, Felder R, Periasamy A, Jose P. Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. J Biomed Opt. 2010;15:056003 pubmed publisher
    ..These studies demonstrate that Ang II-induced AT1R lysosomal degradation through its association with LAMP1 is regulated by Rab5/7 via mechanisms that are dependent on intact actin cytoskeletons. ..
  49. Vizoso M, Ferreira H, López Serra P, Carmona F, Martinez Cardus A, Girotti M, et al. Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR. Nat Med. 2015;21:741-50 pubmed publisher
    ..We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; referred to hereafter as TBC1D16-47KD) to be a characteristic ..
  50. Møller C, Kjøbsted R, Enriori P, Jensen T, Garcia Rudaz C, Litwak S, et al. ?-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS ONE. 2016;11:e0157027 pubmed publisher
    ..We find no evidence to support that -MSH-stimulated glucose uptake involves TBC1D4 phosphorylation (T642 and S704) or GLUT4 translocation. ..
  51. Chauhan I, Shukla R, Krishna S, Sekhri S, Kaushik U, Baby S, et al. Recombinant Leishmania Rab6 (rLdRab6) is recognized by sera from visceral leishmaniasis patients. Exp Parasitol. 2016;170:135-147 pubmed publisher
    ..Our aim was to also assess the diagnostic role of recombinant Rab6 protein from Leishmania donovani (rLdRab6) using sera/plasma of Indian visceral leishmaniasis (VL) patients...
  52. Yamaguchi Y, Sakai E, Okamoto K, Kajiya H, Okabe K, Naito M, et al. Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation. Cell Mol Life Sci. 2018;75:33-48 pubmed publisher
    Rab44 is an atypical Rab GTPase that contains some additional domains such as the EF-hand and coiled-coil domains as well as Rab-GTPase domain...
  53. Carpier J, Zucchetti A, Bataille L, Dogniaux S, Shafaq Zadah M, Bardin S, et al. Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation. J Exp Med. 2018;215:1245-1265 pubmed publisher
    ..This retrograde transport of LAT depends on the small GTPase Rab6 and the target soluble N-ethylmaleimide-sensitive factor attachment protein receptor (t-SNARE) Syntaxin-16, ..
  54. Tatebe H, Morigasaki S, Murayama S, Zeng C, Shiozaki K. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol. 2010;20:1975-82 pubmed publisher
    ..In its GTP-bound form, Ryh1, an evolutionarily conserved Rab GTPase, activates TORC2 signaling to the AGC kinase Gad8...
  55. Villarroel Campos D, Bronfman F, Gonzalez Billault C. Rab GTPase signaling in neurite outgrowth and axon specification. Cytoskeleton (Hoboken). 2016;73:498-507 pubmed publisher
    ..Finally, discussion will be provided on how specific effector-mediated Rab activation modifies several molecules essential to neuronal differentiation. © 2016 Wiley Periodicals, Inc. ..
  56. Das S, Lambright D. Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses. Curr Biol. 2016;26:R927-R929 pubmed publisher
    Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating ..
  57. Zhou Z, Menzel F, Benninghoff T, Chadt A, Du C, Holman G, et al. Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. FEBS Lett. 2017;591:88-96 pubmed publisher
    ..Our results indicate that Rab28 is a novel GTPase involved in the intracellular retention of GLUT4 in insulin target cells. ..
  58. Zhan L, Chen S, Li K, Liang D, Zhu X, Liu L, et al. Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis. 2017;8:e2949 pubmed publisher
    Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has a unique role in the regulation of autophagy...
  59. Wang J, Davis S, Menon S, Zhang J, Ding J, Cervantes S, et al. Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy. J Cell Biol. 2015;210:273-85 pubmed publisher
    ..Instead, we show here that the Rab GTPase Ypt1/Rab1 binds and activates Hrr25/CK1δ to spatially regulate its kinase activity...
  60. Sengupta P, Satpute Krishnan P, Seo A, Burnette D, Patterson G, Lippincott Schwartz J. ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization. Proc Natl Acad Sci U S A. 2015;112:E6752-61 pubmed publisher
    ..Using our trapping scheme, we identify roles of rab6a and calcium-independent phospholipase A2 (iPLA2) in Golgi enzyme recycling, and show that retrograde transport of ..
  61. Shrestha B, Karki H, Groth D, Jungkhun N, Ham J. Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice. PLoS ONE. 2016;11:e0146764 pubmed publisher
    ..The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B...
  62. Lee M, Yoo Y, Kim D, Hanh N, Kwon Y, Hwang I. The Prenylated Rab GTPase Receptor PRA1.F4 Contributes to Protein Exit from the Golgi Apparatus. Plant Physiol. 2017;174:1576-1594 pubmed publisher
    ..F4 is involved in the exit of many but not all types of post-Golgi proteins from the Golgi apparatus. Additionally, an appropriate level of AtPRA1.F4 is crucial for its function at the Golgi apparatus. ..
  63. Jaldin Fincati J, Pavarotti M, Frendo Cumbo S, Bilan P, Klip A. Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action. Trends Endocrinol Metab. 2017;28:597-611 pubmed publisher
    ..We describe recent findings on Akt-targeted Rab GTPase-activating proteins (GAPs) (TBC1D1, TBC1D4, TBC1D13) and downstream Rab GTPases (Rab8a, Rab10, Rab13, Rab14, and ..
  64. Scheper W, Hoozemans J, Hoogenraad C, Rozemuller A, Eikelenboom P, Baas F. Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress. Neuropathol Appl Neurobiol. 2007;33:523-32 pubmed
    ..In this study, we investigated the small GTPase Rab6, which is involved in retrograde Golgi-ER trafficking and may function as a post-ER quality control system...
  65. Zou L, Zhou J, Zhang J, Li J, Liu N, Chai L, et al. The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells. Proc Natl Acad Sci U S A. 2009;106:15801-6 pubmed publisher
    ..Together, these data demonstrate that Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation. ..
  66. Pusapati G, Luchetti G, Pfeffer S. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. J Biol Chem. 2012;287:42129-37 pubmed publisher
    ..Human Ric1 and Rgp1 both bind Rab6A with preference for the GDP-bound conformation, characteristic of a GEF...
  67. Lee P, Ohlson M, Pfeffer S. Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering. elife. 2015;4: pubmed publisher
    ..We report here a novel function for KIF1C: it transports Rab6A-vesicles and can influence Golgi complex organization...
  68. Chandra M, Datta S. Role of cysteine residues in the redox-regulated oligomerization and nucleotide binding to EhRabX3. Mol Biochem Parasitol. 2016;208:84-90 pubmed publisher
    ..EhRabX3, a unique amoebic Rab GTPase with tandem G-domains, possesses an unusually large number of cysteine residues in its N-terminal domain...
  69. Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, et al. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017;486:738-743 pubmed publisher
    ..Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts...
  70. Wakade R, Labbaoui H, Stalder D, Arkowitz R, Bassilana M. Overexpression of YPT6 restores invasive filamentous growth and secretory vesicle clustering in a Candida albicans arl1 mutant. Small Gtpases. 2017;:1-7 pubmed publisher
    ..cerevisiae, is unknown. Here, we investigated the importance of the Rab6 homolog, Ypt6, in Arl1-dependent hyphal growth and determined that YPT6 overexpression specifically rescued the ..
  71. Zahraoui A, Touchot N, Chardin P, Tavitian A. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. J Biol Chem. 1989;264:12394-401 pubmed
    Seven cDNA clones corresponding to the rab1, rab2, rab3A, rab3B, rab4, rab5, and rab6 genes were isolated from a human pheochromocytoma cDNA library...
  72. Cremers F, Armstrong S, Seabra M, Brown M, Goldstein J. REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem. 1994;269:2111-7 pubmed
    ..equal in facilitating the attachment of GG groups to several Rab proteins, including Rab1A, Rab5A, and Rab6. However, REP-2 was only 25% as active as REP-1 in supporting GG attachment to Rab3A and Rab3D...
  73. Echard A, Jollivet F, Martinez O, Lacapere J, Rousselet A, Janoueix Lerosey I, et al. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science. 1998;279:580-5 pubmed
    ..Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified...
  74. Barr F. A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. Curr Biol. 1999;9:381-4 pubmed
    ..The domain preferentially bound to Rab6 on protein blots, and mutations that abolished Golgi targeting resulted in a loss of this interaction...
  75. Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni C. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). Biochem Biophys Res Commun. 1999;258:657-62 pubmed
    ..This protein interacts strongly with the Rab4b, Rab5a, and Rab5c proteins and weakly with Rab4a, Rab6, Rab7, Rab17, and Rab22 in the two-hybrid assay...
  76. Bergbrede T, Pylypenko O, Rak A, Alexandrov K. Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution. J Struct Biol. 2005;152:235-8 pubmed
    ..Members of this group display intrinsic GTPase activity varying over two orders of magnitude. Here, we show that Rab6A represents the RabGTPase with the slowest spontaneous GTPase activity yet measured (5x10(-6)s(-1))...
  77. Storrie B, Micaroni M, Morgan G, Jones N, Kamykowski J, Wilkins N, et al. Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number. Traffic. 2012;13:727-44 pubmed publisher
    We have shown previously that Rab6, a small, trans-Golgi-localized GTPase, acts upstream of the conserved oligomeric Golgi complex (COG) and ZW10/RINT1 retrograde tether complexes to maintain Golgi homeostasis...
  78. Chen Y, Machner M. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infect Immun. 2013;81:2226-35 pubmed publisher
    ..Among those proteins is LidA, an effector that interacts with several host GTPases of the Rab family, including Rab6A', a regulator of retrograde vesicle trafficking within eukaryotic cells...
  79. Peeters K, Litvinenko I, Asselbergh B, Almeida Souza L, Chamova T, Geuens T, et al. Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance. Am J Hum Genet. 2013;92:955-64 pubmed publisher
    ..In addition, the altered protein had a reduced colocalization with RAB6A, a regulator of vesicle trafficking between the Golgi and the endoplasmic reticulum. The interaction between p...
  80. Nandez R, Balkin D, Messa M, Liang L, Paradise S, Czapla H, et al. A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells. elife. 2014;3:e02975 pubmed publisher
    ..These results indicate that OCRL acts as an uncoating factor and that defects in clathrin-mediated endocytosis likely contribute to pathology in patients with OCRL mutations. ..
  81. Shibata S, Kawanai T, Hara T, Yamamoto A, Chaya T, Tokuhara Y, et al. ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles. J Cell Sci. 2016;129:3620-3634 pubmed
    ..ARHGEF10 was found to localize to vesicles containing Rab6 (of which there are three isoforms, Rab6a, Rab6b and Rab6c), Rab8 (of which there are two isoforms, Rab8a and Rab8b), and/or the secretion marker ..
  82. Iancu O, Colville A, Walter N, Darakjian P, Oberbeck D, Daunais J, et al. On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. Addict Biol. 2017;: pubmed publisher
    ..Overall, the data illustrate that excessive ethanol self-administration is associated with broad expression and splicing mechanisms that involve membrane and synapse genes...
  83. Ku B, You J, Oh K, Yun H, Lee H, Shin H, et al. Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase. Arch Virol. 2017;162:3407-3416 pubmed publisher
    ..Herein, we report the first crystal structures of GDP- and GTP-bound forms of APMV Rab GTPase, both of which were determined at high resolution...
  84. Miserey Lenkei S, Bousquet H, Pylypenko O, Bardin S, Dimitrov A, Bressanelli G, et al. Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions. Nat Commun. 2017;8:1254 pubmed publisher
    ..In this study, we investigated whether RAB6 GTPase, a Golgi-associated RAB involved in the regulation of several transport steps at the Golgi level, and two of ..
  85. Steger M, Diez F, Dhekne H, Lis P, Nirujogi R, Karayel Ö, et al. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. elife. 2017;6: pubmed publisher
    ..These results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to LRRK2-dependent pathologies. ..
  86. Banworth M, Li G. Consequences of Rab GTPase Dysfunction in Genetic or Acquired Human Diseases. Small Gtpases. 2017;: pubmed publisher
    ..In this review, we cover recent advances in the field with an emphasis on cellular mechanisms...
  87. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
    ..In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the trafficking of Shiga toxin from the cell surface to the Golgi ..
  88. Wanschers B, van de Vorstenbosch R, Wijers M, Wieringa B, King S, Fransen J. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. Cell Motil Cytoskeleton. 2008;65:183-96 pubmed
    ..Three isoforms of Rab6 have been identified, the ubiquitously expressed Rab6A and Rab6A', and the brain specific Rab6B...
  89. Houghton F, Chew P, Lodeho S, Goud B, Gleeson P. The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1. Cell. 2009;138:787-94 pubmed publisher
    ..Recently, GCC185 was proposed to localize to the Golgi by the co-operation of two small GTPases, Rab6A/A' and Arl1 (Burguete et al., 2008), a model based predominantly on in vitro interactions...
  90. Indran S, Britt W. A role for the small GTPase Rab6 in assembly of human cytomegalovirus. J Virol. 2011;85:5213-9 pubmed publisher
    ..We found that the small GTPase Rab6 also interacts indirectly with pp150 through its interaction with Bicaudal D1...
  91. Shin Y, Yoon J, Jang T, Kim S, Heo W, So I, et al. Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²? binding with opened GTP-binding domain. Biochem Biophys Res Commun. 2012;424:269-73 pubmed publisher
    ..b>Rab6A, a member of the Ras superfamily, is involved in the regulation of vesicle trafficking, which is critical for ..
  92. Huang H, Jiang Y, Wang Y, Chen T, Yang L, He H, et al. miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Cancer Lett. 2015;362:15-24 pubmed publisher
    ..Using a bioinformatics target prediction tool, we identified Rab6 as a potential target of miR-5100...