RAB4A

Summary

Gene Symbol: RAB4A
Description: RAB4A, member RAS oncogene family
Alias: HRES-1, HRES-1/RAB4, HRES1, RAB4, ras-related protein Rab-4A, HTLV-1 related endogenous sequence
Species: human
Products:     RAB4A

Top Publications

  1. Nagelkerken B, Van Anken E, van Raak M, Gerez L, Mohrmann K, Van Uden N, et al. Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles. Biochem J. 2000;346 Pt 3:593-601 pubmed
    The small GTPase rab4a is associated with early endocytic compartments and regulates receptor recycling from early endosomes...
  2. Fouraux M, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, et al. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. Mol Biol Cell. 2004;15:611-24 pubmed
    ..internalization and recycling of transferrin from early endosomes, suggesting that it may be functionally linked to rab4 and rab5...
  3. Nagy G, Ward J, Mosser D, Koncz A, Gergely P, Stancato C, et al. Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. J Biol Chem. 2006;281:34574-91 pubmed
    ..This transcript codes for a 218-amino acid protein, termed HRES-1/Rab4, based on homology to the Rab4 family of small GTPases...
  4. Shisheva A, Chinni S, DeMarco C. General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. Biochemistry. 1999;38:11711-21 pubmed
    ..several Rab family members, divergent in structure, localized and operating on different membranes, including Rab2, Rab4, Rab5, Rab8, Rab9, and Rab11...
  5. Eathiraj S, Pan X, Ritacco C, Lambright D. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005;436:415-9 pubmed
  6. van der Sluijs P, Hull M, Huber L, Male P, Goud B, Mellman I. Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle. EMBO J. 1992;11:4379-89 pubmed
    The ras-like GTP binding protein rab4 is the only known rab protein on endosomes that is phosphorylated during mitosis...
  7. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, et al. Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5. EMBO J. 1998;17:1941-51 pubmed
    ..This domain mediates the direct interaction with the GTP-bound form of Rab4, a small GTPase that has been implicated in recycling from early endosomes to the cell surface...
  8. Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand Brustel Y. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci U S A. 2001;98:1637-42 pubmed
    The small GTPase Rab4 is implicated in endocytosis in all cell types, but also plays a specific role in some regulated processes...
  9. Lindsay A, Hendrick A, Cantalupo G, Senic Matuglia F, Goud B, Bucci C, et al. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. J Biol Chem. 2002;277:12190-9 pubmed
    b>Rab4 and Rab11 are small GTPases belonging to the Ras superfamily. They both function as regulators along the receptor recycling pathway...

More Information

Publications142 found, 100 shown here

  1. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, et al. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic. 2003;4:97-112 pubmed
    The small GTPase Rab4 is involved in endocytosis through sorting and recycling early endosomes...
  2. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky J. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003;23:4892-900 pubmed
    ..In this study, we investigated the role of Rab4, a small GTPase-binding protein, and the motor protein KIF3 (kinesin II in mice) in insulin-induced GLUT4 ..
  3. Lindsay A, McCaffrey M. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. FEBS Lett. 2004;571:86-92 pubmed
    ..Several Rab11-FIPs can also interact with other small GTPases. RCP interacts with Rab4 in addition to Rab11...
  4. Fernandez D, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton F, et al. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol. 2009;182:2063-73 pubmed publisher
    ..Activation of mTOR was inducible by NO, a key trigger of MHP, which in turn enhanced the expression of HRES-1/Rab4, a small GTPase that regulates recycling of surface receptors through early endosomes...
  5. Rivero Ríos P, Romo Lozano M, Madero Pérez J, Thomas A, Biosa A, Greggio E, et al. The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A. J Biol Chem. 2019;294:4738-4758 pubmed publisher
    ..of pathogenic G2019S LRRK2 or loss of RAB8A interfered with EGFR degradation by causing its accumulation in a RAB4-positive endocytic compartment, which was accompanied by a deficit in EGFR recycling and was rescued upon ..
  6. Nogueras Ortiz C, Roman Vendrell C, Mateo Semidey G, Liao Y, Kendall D, Yudowski G. Retromer stops beta-arrestin 1-mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell. 2017;28:3554-3561 pubmed publisher
    ..Then we demonstrate that ERK1/2 activation is mediated by beta-arrestin 1 from receptors localized exclusively at Rab4/5 compartments...
  7. Bian J, Zhang S, Yi M, Yue M, Liu H. The mechanisms behind decreased internalization of angiotensin II type 1 receptor. Vascul Pharmacol. 2018;103-105:1-7 pubmed publisher
    ..4) The enhanced activity and upregulated expression of small GTP-binding protein 4 (Rab4) and 11 (Rab11), which regulate receptor recycling, and phosphatidylinositol 3-kinase increase AT1R ..
  8. Chrifi I, Louzao Martinez L, Brandt M, van Dijk C, Bürgisser P, Zhu C, et al. CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions. Angiogenesis. 2019;22:75-93 pubmed publisher
    ..Intracellular staining revealed that CMTM4 colocalizes with Rab4+ and Rab7+ vesicles, both markers of the endocytic trafficking pathway...
  9. Linford A, Yoshimura S, Nunes Bastos R, Langemeyer L, Gerondopoulos A, Rigden D, et al. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. Dev Cell. 2012;22:952-66 pubmed publisher
    Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell ..
  10. Del Olmo T, Lauzier A, Normandin C, Larcher R, Lecours M, Jean D, et al. APEX2-mediated RAB proximity labeling identifies a role for RAB21 in clathrin-independent cargo sorting. EMBO Rep. 2019;20: pubmed publisher
    ..By comparing quantitative affinity purifications of GFP:RAB21 with APEX2-mediated proximity labeling of RAB4a, RAB5a, RAB7a, and RAB21, we find that APEX2 proximity labeling allows for the comprehensive identification of RAB ..
  11. Mishra A, Eathiraj S, Corvera S, Lambright D. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A. 2010;107:10866-71 pubmed publisher
    ..Although critical determinants are identified in both switch regions, Rab4-to-Rab5 conversion-of-specificity mutants reveal an essential requirement for additional substitutions in the ..
  12. Takahashi M, Murate M, Fukuda M, Sato S, Ohta A, Kobayashi T. Cholesterol controls lipid endocytosis through Rab11. Mol Biol Cell. 2007;18:2667-77 pubmed
    ..Our results indicate that rab11 but not rab4, altered intracellular localization in a cell confluency-associated manner, and this alteration was dependent on ..
  13. de Souza L, Ong H, Liu X, Ambudkar I. Fast endocytic recycling determines TRPC1-STIM1 clustering in ER-PM junctions and plasma membrane function of the channel. Biochim Biophys Acta. 2015;1853:2709-21 pubmed publisher
    ..by Arf6-dependent pathway, sorted to Rab5-containing early endosomes, and trafficked to ER-PM junctions by Rab4-dependent fast recycling...
  14. Snyder J, Rochelle L, Lyerly H, Caron M, BARAK L. Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J Biol Chem. 2013;288:10286-97 pubmed publisher
    ..However, LGR5 fails to rapidly recycle to the plasmid membrane through Rab4-positive vesicles, as is common for other GPCRs...
  15. Park S, Schonhoff C, Webster C, Anwer M. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 2014;307:G863-70 pubmed publisher
    Rab proteins (Ras homologous for brain) play an important role in vesicle trafficking. Rab4 and Rab11 are involved in vesicular trafficking to the plasma membrane from early endosomes and recycling endosomes, respectively...
  16. Gillingham A, Sinka R, Torres I, Lilley K, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358-73 pubmed publisher
    ..We confirm over 25 interactions for Rab2, Rab4, Rab5, Rab6, Rab7, Rab9, Rab18, Rab19, Rab30, and Rab39...
  17. Marilovtseva E, Dubatolova T, Galimova J, Kopyl S, Omelyanchuk L. [COMPARATIVE STUDY OF Hrs AND OTHER ENDOSOMAL MARKERS CELLULAR LOCALIZATION IN DROSOPHILA MELANOGASTER SPERMATOGENESIS BY GFP-CHIMERICAL PROTEIN APPROACH]. Tsitologiia. 2015;57:509-17 pubmed
    ..Additionally, we demonstrated that Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle.
  18. Kaddai V, Gonzalez T, Keslair F, Gremeaux T, Bonnafous S, Gugenheim J, et al. Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte. PLoS ONE. 2009;4:e5257 pubmed publisher
    Endosomal small GTPases of the Rab family, among them Rab4a, play an essential role in the control of the glucose transporter GLUT4 trafficking, which is essential for insulin-mediated glucose uptake...
  19. Ostrowski S, Johnson K, Siefert M, Shank S, Sironi L, Wolozin B, et al. Simvastatin inhibits protein isoprenylation in the brain. Neuroscience. 2016;329:264-74 pubmed publisher
    ..We report that simvastatin significantly inhibits RhoA and Rab4, and Rab6 isoprenylation at doses as low as 50nM in vitro...
  20. Kofler N, Corti F, Rivera Molina F, Deng Y, Toomre D, Simons M. The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. J Biol Chem. 2018;293:4805-4817 pubmed publisher
    ..high-resolution microscopy and biochemical assays, we demonstrate that RABEP2 interacts with the small GTPase Rab4 and regulates VEGFR2 endosomal trafficking to maintain cell-surface expression of VEGFR2 and VEGF signaling...
  21. Deissler H, Lang G, Lang G. Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation. Graefes Arch Clin Exp Ophthalmol. 2019;257:83-94 pubmed publisher
    ..e., endosomal Rab4 and Rab11, components of the cytoskeleton, motor proteins, or with marker proteins characteristic of multivesicular ..
  22. Bannister J, Bulley S, Leo M, Kidd M, Jaggar J. Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells. Am J Physiol Cell Physiol. 2016;310:C885-93 pubmed publisher
    ..In contrast, CaV1.2 was not located nearby Rab11A or Rab4 and CaV1.2 protein was unaltered by Rab11A or Rab4A knockdown. Rab25 knockdown resulted in CaV1...
  23. Prabhu V, Nguyen T, Cui Y, Oh Y, Lee K, Bagalkot T, et al. Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking. Behav Brain Funct. 2018;14:16 pubmed publisher
    ..Furthermore, increased expression of D2L, D2S, Rab4, and G protein-coupled receptor associated sorting protein-1 was observed in the amygdala of the susceptible group ..
  24. Korobko E, Kiselev S, Korobko I. Characterization of Rabaptin-5 γ isoform. Biochemistry (Mosc). 2014;79:856-64 pubmed publisher
    ..Rabaptin-5 is a Rab5 effector in early endosome fusion and connects Rab5- and Rab4-positive membrane compartments owing to its ability to interact with Rab4 GTPase...
  25. Nag S, Rani S, Mahanty S, Bissig C, Arora P, Azevedo C, et al. Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles. J Cell Sci. 2018;131: pubmed publisher
    ..Here, RNAi screening in melanocytes revealed that knockdown of Rab4A results in defective melanosome maturation...
  26. Strick D, Elferink L. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol Biol Cell. 2005;16:5699-709 pubmed
    ..compartment specific, colocalizing with Rab15 and Rab11 on the endocytic recycling compartment but not with Rab15, Rab4, or early endosome antigen 1 on sorting endosomes...
  27. Schonhoff C, Thankey K, Webster C, Wakabayashi Y, Wolkoff A, Anwer M. Rab4 facilitates cyclic adenosine monophosphate-stimulated bile acid uptake and Na+-taurocholate cotransporting polypeptide translocation. Hepatology. 2008;48:1665-70 pubmed publisher
    ..b>Rab4 is associated with early endosomes and involved in vesicular trafficking...
  28. Ma X, Petrusek A, Wolinska J, Hu W, Yin M. Lineage diversity and reproductive modes of the Daphnia pulex group in Chinese lakes and reservoirs. Mol Phylogenet Evol. 2019;130:424-433 pubmed publisher
    ..This was further supported by analyses of a small GTPase nuclear gene (rab4), as two alleles within single individuals belonged to different clades...
  29. Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar Piqué A, Branco T, et al. Membrane binding, internalization, and sorting of alpha-synuclein in the cell. Acta Neuropathol Commun. 2018;6:79 pubmed publisher
    ..Initially, aSyn accumulated in Rab4A-labelled vesicles and, at later stages, it reached the autophagy-lysosomal pathway (ALP) where it gets degraded...
  30. Rzomp K, Moorhead A, Scidmore M. The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229. Infect Immun. 2006;74:5362-73 pubmed
    ..have been clearly identified, several enhanced green fluorescent protein (GFP)-tagged Rab GTPases, including Rab4A, are recruited to chlamydial inclusions...
  31. Perl A, Nagy G, Koncz A, Gergely P, Fernandez D, Doherty E, et al. Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE. Autoimmunity. 2008;41:287-97 pubmed publisher
    ..As examples, the HRES-1 human ERV encodes a 28-kDa nuclear autoantigen and a 24-kDa small GTP-ase, termed HRES-1/Rab4. HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies, while HRES-1/Rab4 regulates ..
  32. Hellberg C, Schmees C, Karlsson S, Ahgren A, Heldin C. Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. Mol Biol Cell. 2009;20:2856-63 pubmed publisher
    Previous studies showed that loss of the T-cell protein tyrosine phosphatase (TC-PTP) induces Rab4a-dependent recycling of the platelet-derived growth factor (PDGF) beta-receptor in mouse embryonic fibroblasts (MEFs)...
  33. Brejchová J, Vosahlikova M, Roubalová L, Parenti M, Mauri M, Chernyavskiy O, et al. Plasma membrane cholesterol level and agonist-induced internalization of ?-opioid receptors; colocalization study with intracellular membrane markers of Rab family. J Bioenerg Biomembr. 2016;48:375-96 pubmed publisher
    ..presence of receptors in early endosomes (Rab5), late endosomes and lysosomes (Rab7) and fast recycling vesicles (Rab4). Slow type of recycling (Rab11) was unchanged by cholesterol depletion...
  34. Leo M, Bulley S, Bannister J, Kuruvilla K, Narayanan D, Jaggar J. Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction. Am J Physiol Cell Physiol. 2015;309:C392-402 pubmed publisher
    ..resonance energy transfer (immunoFRET) microscopy, and RNAi-mediated knockdown, we demonstrate that rab4A-positive early endosomes traffic BKα to the plasma membrane in myocytes of resistance-size cerebral arteries...
  35. Mölleken K, Hegemann J. Acquisition of Rab11 and Rab11-Fip2-A novel strategy for Chlamydia pneumoniae early survival. PLoS Pathog. 2017;13:e1006556 pubmed publisher
    ..Immediately after entry, the early chlamydial inclusion acquires early endosomal Rab GTPases including Rab4, Rab5, Rab7, as well as the two recycling-specific Rabs Rab11 and Rab14...
  36. D Angelo G, Matusek T, Pizette S, Thérond P. Endocytosis of Hedgehog through dispatched regulates long-range signaling. Dev Cell. 2015;32:290-303 pubmed publisher
    ..Re-internalized Hh is then regulated in a Rab5- and Rab4-dependent manner to ensure its long-range activity...
  37. Rains A, Bryant Y, Dorsett K, Culver A, Egbaria J, Williams A, et al. Ypt4 and lvs1 regulate vacuolar size and function in Schizosaccharomyces pombe. Cell Logist. 2017;7:e1335270 pubmed publisher
    ..of the Chediak-Higashi Syndrome CHS1/LYST gene, increases vacuolar size, similar to deletion of the Rab4 homolog ypt4...
  38. Stibbs H, Seed J. Short-term metabolism of (14-C) tryptophan in rats infected with Trypanosoma brucei gambiense. J Infect Dis. 1975;131:459-62 pubmed
    ..These results indicate that dietary tryptophan may be diverted from the kynurenine and serotonin pathways by parasite metabolism to compounds possessing potential pharmacological or toxic activity. ..
  39. Pagano A, Crottet P, Prescianotto Baschong C, Spiess M. In vitro formation of recycling vesicles from endosomes requires adaptor protein-1/clathrin and is regulated by rab4 and the connector rabaptin-5. Mol Biol Cell. 2004;15:4990-5000 pubmed
    ..The GTPase rab4, but not rab5, was required to generate endosome-derived vesicles...
  40. Magunda F, Thompson C, Schneider D, Noh S. Anaplasma marginale Actively Modulates Vacuolar Maturation during Intracellular Infection of Its Tick Vector, Dermacentor andersoni. Appl Environ Microbiol. 2016;82:4715-4731 pubmed publisher
    ..tick vacuoles (AmVs) concurrently recruit markers of the early endosome (Rab5), recycling endosome (Rab4 and Rab11), and late endosome (Rab7), are maintained near neutral pH, do not fuse with lysosomes, exclude the ..
  41. Edwards D, Gilbert J, Hicks J, Myers J, Jiang L, Cummings A, et al. Linkage and association of successful aging to the 6q25 region in large Amish kindreds. Age (Dordr). 2013;35:1467-77 pubmed publisher
    ..89?×?10(-6)). These findings suggest potentially novel genes in the 6q25-q27 region linked and associated with SA in the Amish; however, these findings should be verified in an independent replication cohort. ..
  42. Enomoto S, Shimizu K, Nibuya M, Toda H, Yoshino A, Suzuki E, et al. Increased expression of endocytosis-Related proteins in rat hippocampus following 10-day electroconvulsive seizure treatment. Neurosci Lett. 2016;624:85-91 pubmed publisher
    ..caveolin-1, flotillin-1, and heavy and light chains of clathrin) and small GTPases (Rab5, Rab7, Rab11, and Rab4) specifically expressed on various types of endosomes...
  43. Ostalecki C, Wittki S, Lee J, Geist M, Tibroni N, Harrer T, et al. HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection. EBioMedicine. 2016;13:294-304 pubmed publisher
    ..Key event was the Nef-mediated routing of the TNF-converting enzyme ADAM17 into Rab4+ early endosomes and the Rab27+ secretory pathway...
  44. Banerjee M, Joshi S, Zhang J, Moncman C, Yadav S, Bouchard B, et al. Cellubrevin/vesicle-associated membrane protein-3-mediated endocytosis and trafficking regulate platelet functions. Blood. 2017;130:2872-2883 pubmed publisher
    ..Dextran uptake was rapid compared with Fg, but both cargoes progressed through Rab4+, Rab11+, and von Willebrand factor (VWF)+ compartments in wild-type platelets in ..
  45. Amann W. [Preovulatory appearance of herpes labialis]. Hautarzt. 1975;26:47 pubmed
  46. Bananis E, Nath S, Gordon K, Satir P, Stockert R, Murray J, et al. Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Mol Biol Cell. 2004;15:3688-97 pubmed
    ..asialoglycoprotein and its receptor and move and undergo fission along microtubules using kinesin I and KIFC2, with Rab4 regulating KIFC2 activity (J. Cell Sci. 116, 2749, 2003)...
  47. Conti F, Sertic S, Reversi A, Chini B. Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 "short cycle". Am J Physiol Endocrinol Metab. 2009;296:E532-42 pubmed publisher
    ..investigations of receptor recycling pathways showed that OTRs localize in vesicles containing the Rab5 and Rab4 small GTPases (markers of the "short cycle"), whereas there was no colocalization with Rab11 (a marker of ..
  48. Gomez Lamarca M, Snowdon L, Seib E, Klein T, Bray S. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol. 2015;210:303-18 pubmed publisher
    ..In the absence of Rme-8, Notch accumulated in enlarged tubulated Rab4-positive endosomes, and as a consequence, signaling was compromised...
  49. Faraz M, Herdenberg C, Holmlund C, Henriksson R, Hedman H. A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors. J Biol Chem. 2018;293:3421-3435 pubmed publisher
    ..The network contains the apparently functionally important LRIG1-interacting proteins RAB4A, PON2, GAL3ST1, ZBTB16, LRIG2, CNPY3, HLA-DRA, GML, CNPY4, LRRC40, and LRIG3, together with GLRX3, PTPRK, and ..
  50. Gromova K, Muhia M, Rothammer N, Gee C, Thies E, Schaefer I, et al. Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior. Cell Rep. 2018;23:2705-2717 pubmed publisher
    ..NBEA dynamically interacts with Rab4-positive recycling endosomes, transiently enters spines in an activity-dependent manner, and regulates GluN2B-NMDAR ..
  51. de Madrid B, Greenberg L, Hatini V. RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs. Dev Biol. 2015;399:283-95 pubmed publisher
    ..We show that the RhoGAP68F protein localizes to Rab4 recycling endosomes and forms a complex with the Rab4 protein...
  52. Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke T. Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice. FASEB J. 2016;30:2476-89 pubmed publisher
    ..Electrophysiological alterations in Kcne3(-/-) mice were aldosterone dependent and were associated with increased Rab4, -5, and -9-dependent recycling of Kv1...
  53. Ho E, Ivanova I, Dagnino L. Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes. Biochim Biophys Acta. 2016;1863:2892-2904 pubmed publisher
    ..induction of keratinocyte differentiation by Ca2+ is accompanied by localization of ELMO2 and ILK to Rab4- and Rab11a-containing recycling endosomes...
  54. Rousseau Merck M, Zahraoui A, Touchot N, Tavitian A, Berger R. Chromosome assignment of four RAS-related RAB genes. Hum Genet. 1991;86:350-4 pubmed
    ..We used four human RAB-cDNAs, RAB3B, RAB4, RAB5 and RAB6, to map the corresponding genes on human chromosomes...
  55. Gallo L, Liao Y, Ruiz W, Clayton D, Li M, Liu Y, et al. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol Biol Cell. 2014;25:3779-97 pubmed publisher
    ..5 mM), TBC1D9B interacted via its Tre2-Bub2-Cdc16 (TBC) domain with Rab11a, Rab11b, and Rab4a in a nucleotide-dependent manner. However, only Rab11a was a substrate for TBC1D9B-stimulated GTP hydrolysis...
  56. Zhang J, Chang D, Yang Y, Zhang X, Tao W, Jiang L, et al. Systematic investigation on the intracellular trafficking network of polymeric nanoparticles. Nanoscale. 2017;9:3269-3282 pubmed publisher
    ..Moreover, the slow (Rab11 and Rab35 positive), fast (Rab4 positive) and apical (Rab20 and Rab25 positive) endocytic recycling endosome pathways could transport the PLGA ..
  57. Vielh E, Touchot N, Zahraoui A, Tavitian A. Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein. Nucleic Acids Res. 1989;17:1770 pubmed
  58. Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard B, et al. Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking. Blood. 2016;127:1459-67 pubmed publisher
    ..Immunofluorescence analysis showed initial trafficking of FITC-Fg to a Rab4-positive compartment followed by colocalization with Rab11-positive structures, suggesting that platelets contain ..
  59. Ivan V, van der Sluijs P. Methods for analysis of AP-3/Rabin4' in regulation of lysosome distribution. Methods Mol Biol. 2015;1298:245-58 pubmed publisher
    ..We recently found that the rab5 and rab4 effector rabip4' interacts with the adaptor complex AP-3 in a rab4-dependent manner on tubular endosomes...
  60. Chen J, Guo J, Yang T, Li W, Lamothe S, Kang Y, et al. Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel. J Biol Chem. 2015;290:21101-13 pubmed publisher
    ..GTPase Rab11, but not Rab4, is involved in the recycling of hERG channels...
  61. Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, et al. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Dev Cell. 2009;16:687-98 pubmed publisher
    ..These results establish an ubiquitin-based endosomal switch of receptor sorting, functionally equivalent to the mechanism inactivating Hrs via monoubiquitinylation. ..
  62. Tower Gilchrist C, Lee E, Sztul E. Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3. Biochem Biophys Res Commun. 2011;413:555-60 pubmed publisher
    ..We used real time imaging to show that somatostatin receptor 3 (SSTR3) traffics through Rab4-, Rab21-, and Rab11-containing endosomes, but largely bypasses Rab5 and Rab7 endosomes...
  63. Chichger H, Braza J, Duong H, Boni G, Harrington E. Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin. Am J Respir Cell Mol Biol. 2016;54:769-81 pubmed publisher
    ..The key trafficking pathways are regulated by Rab4, -7, and -9...
  64. Schafer J, McRae R, Manning E, Lapierre L, Goldenring J. Rab11-FIP1A regulates early trafficking into the recycling endosomes. Exp Cell Res. 2016;340:259-73 pubmed publisher
    ..We also found that Rab5 and EEA1 were accumulated in membranes by GFP-Rab11-FIP1A but Rab4 was unaffected, suggesting that a direct pathway may exist from early endosomes into the Rab11a-containing ..
  65. Jacomin A, Fauvarque M, Taillebourg E. A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila. BMC Cell Biol. 2016;17:36 pubmed
    ..fat body cells either dsRNAs or dominant negative mutants targeting components of the endosomal machinery: Shibire, Rab4, Rab5, Chmp1 and Rab7...
  66. Vuorenpää A, Jørgensen T, Newman A, Madsen K, Scheinin M, Gether U. Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini. J Biol Chem. 2016;291:5634-51 pubmed publisher
    ..with the "long loop" recycling marker Rab11, whereas less overlap was seen with the "short loop" recycling marker Rab4 and the late endosomal marker Rab7...
  67. Jonker C, Galmes R, Veenendaal T, ten Brink C, van der Welle R, Liv N, et al. Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions. Nat Commun. 2018;9:792 pubmed publisher
    ..Vps3 and Vps8 localise to Rab4-positive recycling vesicles and co-localise with the CHEVI complex on Rab11-positive recycling endosomes...
  68. Wang F, Chen X, Zhang X, Ma L. Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway. Mol Endocrinol. 2008;22:1881-92 pubmed publisher
    ..Inhibition of functions of either Rab4 or Rab11 by dominant-negative mutants and small interfering RNA both significantly impaired the recycling of the ..
  69. Azuma Y, Takada M, Shin H, Kioka N, Nakayama K, Ueda K. Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation. Genes Cells. 2009;14:191-204 pubmed publisher
    ..via a clathrin- and Rab5-mediated pathway and recycled rapidly back to the cell surface, at least in part via a Rab4-mediated route; approximately 30% of the endocytosed ABCA1 is recycled back to the cell surface...
  70. Simino J, Sung Y, Kume R, Schwander K, Rao D. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Front Genet. 2013;4:277 pubmed publisher
    ..SNP-alcohol interactions may enhance discovery of novel variants with large effects that can be targeted with lifestyle modifications. ..
  71. D Souza R, Semus R, Billings E, Meyer C, Conger K, Casanova J. Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes. Curr Biol. 2014;24:1187-98 pubmed publisher
    ..Here we report that the endosomal Rab protein Rab4 orchestrates a GTPase cascade that results in the sequential recruitment of the ADP-ribosylation factor (Arf)-like ..
  72. Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
    ..barrier integrity is vital in neovascularization, we sought to elucidate the role for endosome proteins p18 and Rab4, Rab7, and Rab9 in the process of vessel formation within the pulmonary vasculature...
  73. Błaszczyk M, Gajewska M, Milewska M, Grzelkowska Kowalczyk K. Insulin-dependent cytoplasmic distribution of Rab4a in mouse adipocytes is inhibited by interleukin-6, -8, and -15. Cell Biol Int. 2017;41:457-463 pubmed publisher
    ..the study was to examine the effect of interleukins, IL-6, IL-8, and IL-15, on insulin-mediated redistribution of Rab4a, an early endosome marker, in mouse 3T3-L1 adipocytes...
  74. Janoueix Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem. 1995;270:14801-8 pubmed
    ..functional; we show that recombinant mouse GDI beta is able to remove several Rab proteins, including Rab1, Rab2, Rab4, and Rab6, from membranes...
  75. Goueli B, Powell M, Finger E, Pfeffer S. TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling. Proc Natl Acad Sci U S A. 2012;109:15787-92 pubmed
    b>Rab4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. The protein TBC1D16 is up-regulated in melanoma, and TBC1D16-overexpressing melanoma cells are dependent on TBC1D16...
  76. Zheng L, Conner S. PI5P4K? functions in DTX1-mediated Notch signaling. Proc Natl Acad Sci U S A. 2018;115:E1983-E1990 pubmed publisher
    ..We find that DTX1 silencing leads to enhanced Notch1 recycling from this compartment to the cell surface via a rab4a-mediated transport route. This, in turn, increases Notch1 cell-surface levels and enhances signaling...
  77. Song P, Wu T, Hong M, Chen M. Elevated temperature inhibits recruitment of transferrin-positive vesicles and induces iron-deficiency genes expression in Aiptasia pulchella host-harbored Symbiodinium. Comp Biochem Physiol B Biochem Mol Biol. 2015;188:1-7 pubmed publisher
    ..through transferrin receptor-mediated endocytosis, a vesicular trafficking pathway specifically regulated by Rab4 and Rab5, we set out to examine the roles of these key proteins in the iron acquisition by the symbiotic ..
  78. Takeuchi H, Takada A, Kuboniwa M, Amano A. Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells. Cell Microbiol. 2016;18:928-48 pubmed publisher
    ..In the present study, we found that the pathogen localized in early endosomes recruits VAMP2 and Rab4A. VAMP2 was found to be specifically localized in early endosomes, although its localization remained unclear in ..
  79. Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, et al. Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front Cell Infect Microbiol. 2017;7:67 pubmed publisher
    ..HT29 cells, 34% of internalized TcdA localized to ClC-5-containing vesicles defined by colocalization with Rab5, Rab4a, and Rab7 as early and early-to-late of endosomes but not as Rab11-containing recycling endosomes...
  80. Connor M, Pulsifer A, CHUNG D, Rouchka E, Ceresa B, Lawrenz M. Yersinia pestis Targets the Host Endosome Recycling Pathway during the Biogenesis of the Yersinia-Containing Vacuole To Avoid Killing by Macrophages. MBio. 2018;9: pubmed publisher
    ..Moreover, we demonstrated that Y. pestis actively recruits Rab4a and Rab11b to the YCV in a type three secretion system-independent manner, indicating remodeling of the YCV by ..
  81. Ahmed B, Jeffus B, Bukhari S, Harney J, Unal R, Lupashin V, et al. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol Chem. 2008;283:9388-98 pubmed publisher
    ..It is well reported that stimulation of cells with high [5HT](ex) induces transamidation of a small GTPase, Rab4. Modification with 5HT stabilizes Rab4 in its active, GTP-bound form, Rab4-GTP...
  82. Yamamoto H, Koga H, Katoh Y, Takahashi S, Nakayama K, Shin H. Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4. Mol Biol Cell. 2010;21:2746-55 pubmed publisher
    ..we report that Rab14 binds in a GTP-dependent manner to RUFY1/Rabip4, which had been originally identified as a Rab4 effector. Rab14 colocalizes well with Rab4 on peripheral endosomes...
  83. Schroeder G, Aurass P, Oates C, Tate E, Hartland E, Flieger A, et al. Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor. Infect Immun. 2015;83:3989-4002 pubmed publisher
    ..We found that ectopically expressed LpdA was targeted to the plasma membrane and Rab4- and Rab14-containing vesicles...
  84. Sorvina A, Shandala T, Brooks D. Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo. Biol Open. 2016;5:678-88 pubmed publisher
    ..b>Rab4/Rab11 recycling endosomes are involved in the sorting of immune-mediators into specialist Rab11 vesicles that can ..
  85. Karniguian A, Zahraoui A, Tavitian A. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Proc Natl Acad Sci U S A. 1993;90:7647-51 pubmed
    ..This study has shown that rab1, rab3B, rab4, rab6, and rab8 proteins, but not rab3A protein, were present in platelets and in endothelial cells...
  86. Ward E, Martinez C, Vaccaro C, Zhou J, Tang Q, Ober R. From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. Mol Biol Cell. 2005;16:2028-38 pubmed
    ..is how is the routing of intracellular organelles within cells regulated? Although data support the involvement of Rab4 and Rab11 GTPases in the recycling pathway, the function of Rab11 in particular is uncertain...
  87. Eggers C, Schafer J, Goldenring J, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009;284:32869-80 pubmed publisher
    ..We show here that these RGS domains interact with Rab11 and GTP-bound Rab4, the first demonstration of RGS domains binding small GTPases...
  88. Ginsberg S, Mufson E, Alldred M, Counts S, Wuu J, Nixon R, et al. Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J Chem Neuroanat. 2011;42:102-10 pubmed publisher
    ..Specifically, upregulation of rab4, rab5, rab7, and rab27 was observed in CBF neurons microdissected from postmortem brains of individuals with MCI ..
  89. Webster P, Vanacore L, Nairn A, Marino C. Subcellular localization of CFTR to endosomes in a ductal epithelium. Am J Physiol. 1994;267:C340-8 pubmed
    ..preparation, some of the CFTR-labeled vesicles were also labeled with antibodies against transferrin receptor and rab4, two markers of early endosomes and receptor-mediated endocytosis...
  90. Christoforidis S, Zerial M. Purification and identification of novel Rab effectors using affinity chromatography. Methods. 2000;20:403-10 pubmed
    ..We expect this strategy to provide fundamental insights into the molecular mechanism of membrane transport but also to be applicable to several other GTPase-dependent biological functions. ..
  91. Bielli A, Thörnqvist P, Hendrick A, Finn R, Fitzgerald K, McCaffrey M. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. Biochem Biophys Res Commun. 2001;281:1141-53 pubmed
    ..system to identify proteins that specifically interact with Rab4AQ67L, a GTPase-deficient mutant form of Rab4A. Screening a mouse embryo cDNA library identified a clone (M449) that interacted with Rab4A in a nucleotide-..
  92. de Renzis S, Sönnichsen B, Zerial M. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. Nat Cell Biol. 2002;4:124-33 pubmed
    The three GTPases Rab5, Rab4 and Rab11 regulate sequential transport steps along the endocytic/recycling pathway, and occupy distinct membrane domains on early and recycling endosomes...