RAB3GAP2

Summary

Gene Symbol: RAB3GAP2
Description: RAB3 GTPase activating non-catalytic protein subunit 2
Alias: RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150, rab3 GTPase-activating protein non-catalytic subunit, RAB3 GTPase activating protein subunit 2 (non-catalytic), RGAP-iso, rab3 GTPase-activating protein 150 kDa subunit, rab3-GAP p150, rab3-GAP regulatory subunit
Species: human
Products:     RAB3GAP2

Top Publications

  1. Aligianis I, Johnson C, Gissen P, Chen D, Hampshire D, Hoffmann K, et al. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet. 2005;37:221-3 pubmed
    ..We hypothesize that the underlying pathogenesis of Micro syndrome is a failure of exocytic release of ocular and neurodevelopmental trophic factors. ..
  2. Novarino G, Fenstermaker A, Zaki M, Hofree M, Silhavy J, Heiberg A, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science. 2014;343:506-511 pubmed publisher
    ..Our analysis links HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease...
  3. Nagano F, Sasaki T, Fukui K, Asakura T, Imazumi K, Takai Y. Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. J Biol Chem. 1998;273:24781-5 pubmed
    ..Rab3 GAP showed two bands with Mr of about 130,000 (p130) and 150,000 (p150) on SDS-polyacrylamide gel electrophoresis. p130, but not p150, showed the catalytic activity...
  4. Aligianis I, Morgan N, Mione M, Johnson C, Rosser E, Hennekam R, et al. Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic subunit in a kindred with Martsolf syndrome. Am J Hum Genet. 2006;78:702-7 pubmed
    We identified a homozygous missense mutation in the noncatalytic subunit (RAB3GAP2) of RAB3GAP that results in abnormal splicing in a family with congenital cataracts, hypogonadism, and mild mental retardation (Martsolf syndrome)...
  5. Handley M, Aligianis I. RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes. Biochem Soc Trans. 2012;40:1394-7 pubmed publisher
    ..Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2...
  6. Handley M, Morris Rosendahl D, Brown S, MacDonald F, Hardy C, Bem D, et al. Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. Hum Mutat. 2013;34:686-96 pubmed publisher
    ..Causative biallelic germline mutations have been identified in RAB3GAP1, RAB3GAP2, or RAB18, each of which encode proteins involved in membrane trafficking...
  7. Chen C, Hehnly H, Yu Q, Farkas D, Zheng G, Redick S, et al. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol. 2014;24:2327-2334 pubmed publisher
    ..disruption had no detectable effect on localization of proteins involved in the cortical polarity pathway (NuMA, p150(glued), aPKC)...
  8. Gannon H, Zou T, Kiessling M, Gao G, Cai D, Choi P, et al. Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nat Commun. 2018;9:5450 pubmed publisher
    ..through inactivation of PKR or overexpression of either a wildtype or catalytically inactive mutant version of the p150 isoform of ADAR1, partially rescues cell lethality after ADAR1 loss, suggesting that both catalytic and non-..
  9. Luo Y, Lee I, Jo Y, Namgoong S, Kim N. Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes. Sci Rep. 2016;6:20408 pubmed publisher
    ..Immunofluorescence results also indicated the dislocation of pericentrin and P150(Glued) after SUN1 or KASH5 depletion...

More Information

Publications116 found, 100 shown here

  1. Guo Y, Zheng Y. Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell. 2015;26:3379-89 pubmed publisher
    ..We further show that asymmetric NPC distribution upon lamin depletion disrupts the distribution of BICD2 and p150 dynactin on the nuclear envelope at prophase, which results in inefficient dynein-driven centrosome separation ..
  2. Shibahara K, Stillman B. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell. 1999;96:575-85 pubmed
    ..PCNA binds directly to p150, the largest subunit of CAF-1, and the two proteins colocalize at sites of DNA replication in cells...
  3. Kedashiro S, Pastuhov S, Nishioka T, Watanabe T, Kaibuchi K, Matsumoto K, et al. LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends. J Cell Sci. 2015;128:385-96 pubmed publisher
    ..We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of ..
  4. Omer S, Greenberg S, Lee W. Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1. elife. 2018;7: pubmed publisher
    ..ER- and mitochondria-independent population of Num1, dynein motor activity, and CAP-Gly domain of dynactin Nip100/p150Glued subunit...
  5. Pathak A, Stanley E, Hickman F, Wallace N, Brewer B, Li D, et al. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. Dev Cell. 2018;46:376-387.e7 pubmed publisher
    ..HDAC1 deacetylates dynactin subunit p150Glued, which enhances its interaction with dynein...
  6. Goldspink D, Rookyard C, Tyrrell B, Gadsby J, Perkins J, Lund E, et al. Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres. Open Biol. 2017;7: pubmed publisher
    ..requirement of CLIP-170 for ninein recruitment to n-MTOCs, with possible compensation by other anchoring factors such as p150Glued and CAMSAP2 ensuring apico-basal microtubule formation despite loss of ninein at n-MTOCs.
  7. Crowder M, Flynn J, McNally K, Cortes D, Price K, Kuehnert P, et al. Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. Mol Biol Cell. 2015;26:3030-46 pubmed publisher
    ..We also present evidence that activation of spindle rotation is promoted by dephosphorylation of the basic domain of p150 dynactin.
  8. Adams A, Weinman S, Wozniak A. Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP. Biochem Biophys Res Commun. 2018;503:2619-2624 pubmed publisher
    ..The combination of cleavage and phosphorylation were both needed for release from the dynein component p150Glued and redistribution of CD63+ve intracellular vesicles.
  9. Zhu Q, Wani G, Arab H, El Mahdy M, Ray A, Wani A. Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites. DNA Repair (Amst). 2009;8:262-73 pubmed publisher
    ..Knockdown of CAF-1 p60 abolished CAF-1 as well as uH2A foci formation. CAF-1 p150 was found to associate with NER factors TFIIH, RPA p70 and PCNA in chromatin...
  10. Estrem C, Fees C, Moore J. Dynein is regulated by the stability of its microtubule track. J Cell Biol. 2017;216:2047-2058 pubmed publisher
    ..a mechanism involving the shoulder subcomplex and the cytoskeletal-associated protein glycine-rich domain of Nip100/p150glued Our results support a model in which dynein destabilizes its microtubule substrate by using its ..
  11. Qiu R, Zhang J, Xiang X. p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation. J Biol Chem. 2018;293:15606-15619 pubmed publisher
    ..cargo adapters are implicated in dynein activation via binding to dynactin's pointed end to switch the conformation of p150, a major dynactin component, our results suggest p25 as a critical pointed-end protein involved in this process.
  12. Vodicska B, Cerikan B, Schiebel E, Hoffmann I. MISP regulates the IQGAP1/Cdc42 complex to collectively orchestrate spindle orientation and mitotic progression. Sci Rep. 2018;8:6330 pubmed publisher
    ..acts downsteam of MISP in regulating astral microtubule dynamics and the localization of the dynactin subunit p150glued that is crucial for proper spindle positioning...
  13. Ramsey S, Xu T, Goodall C, Rhodes A, Kashyap A, He J, et al. Cross-species analysis of the canine and human bladder cancer transcriptome and exome. Genes Chromosomes Cancer. 2017;56:328-343 pubmed publisher
    ..Finally we report three novel mutations (FAM133B, RAB3GAP2, and ANKRD52) for canine bladder cancer.
  14. Chen Y, Wang P, Slep K. Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex. J Biol Chem. 2019;294:918-931 pubmed publisher
    ..We found that, unlike the EB1-binding mode of the CAP-Gly domain in the dynactin-associated protein p150Glued, which dually engages the EB1 C-terminal EEY motif as well as the EB homology domain and sterically ..
  15. Wass S, Daubney K, Golan J, Logan F, Kushnerenko E. Elevated physiological arousal is associated with larger but more variable neural responses to small acoustic change in children during a passive auditory attention task. Dev Cogn Neurosci. 2018;:100612 pubmed publisher
    ..In addition, we observed larger P150/P3a amplitudes in response to small acoustic contrasts (750 Hz tones) in the high HR group...
  16. Sanders Beer B, Eschricht M, Seifried J, Hirsch V, Allan J, Norley S. Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages. Virology. 2012;422:402-12 pubmed publisher
    ..0 showed the broadest reactivity recognizing the Gag capsid protein (p24-27) and Gag precursors p38, p55, and p150 of HIV-1, HIV-2, SIVmac, and SIVagm. Using overlapping peptides, the AG3...
  17. Villarin J, McCurdy E, Martinez J, Hengst U. Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands. Nat Commun. 2016;7:13865 pubmed publisher
    ..of large vesicles requires local synthesis of Lis1, while smaller signalling endosomes require both Lis1 and p150Glued...
  18. Konno T, Ross O, Teive H, Sławek J, Dickson D, Wszolek Z. DCTN1-related neurodegeneration: Perry syndrome and beyond. Parkinsonism Relat Disord. 2017;41:14-24 pubmed publisher
    ..The mutated causative gene for PS is DCTN1, which encodes the dynactin subunit p150Glued...
  19. Aktas T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 2017;544:115-119 pubmed publisher
    ..Biochemical purifications of DHX9 identify the interferon-inducible isoform of ADAR (p150), but not the constitutively expressed ADAR isoform (p110), as an RNA-independent interaction partner...
  20. Lee H, Komarova Y, Nadezhdina E, Anjum R, Peloquin J, Schober J, et al. Phosphorylation controls autoinhibition of cytoplasmic linker protein-170. Mol Biol Cell. 2010;21:2661-73 pubmed publisher
    ..N and C termini results in autoinhibition of CLIP-170, thus altering its binding to MTs and the dynactin subunit p150(Glued) (J. Cell Biol. 2004: 166, 1003-1014)...
  21. Jayappa K, Ao Z, Wang X, Mouland A, Shekhar S, Yang X, et al. Human immunodeficiency virus type 1 employs the cellular dynein light chain 1 protein for reverse transcription through interaction with its integrase protein. J Virol. 2015;89:3497-511 pubmed publisher
    ..host dynein adapter proteins such as dynein light chain 1 (DYNLL1), dynein light chain Tctex-type 1 (DYNLT1), and p150(Glued) in early steps of human immunodeficiency virus type 1 (HIV-1) replication...
  22. Yan H, Xiang X, Chen Q, Pan X, Cheng H, Wang F. HP1 cooperates with CAF-1 to compact heterochromatic transgene repeats in mammalian cells. Sci Rep. 2018;8:14141 pubmed publisher
    ..factor 1 (CAF-1) complex concentrates at the transgenic locus through the interaction of its PxVxL motif-containing p150 subunit with HP1. Knockdown of p150 relieves HP1-mediated transgene compaction and repression...
  23. Flores Rodriguez N, Rogers S, Kenwright D, Waigh T, Woodman P, Allan V. Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis. PLoS ONE. 2011;6:e24479 pubmed publisher
    ..For these, it requires an intact dynactin complex to allow membrane-bound p150(Glued) to activate dynein, since p50 over-expression, which disrupts the dynactin complex, inhibits inward movement ..
  24. Tripathy S, Weil S, Chen C, Anand P, Vallee R, Gross S. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Nat Cell Biol. 2014;16:1192-201 pubmed publisher
    ..latter function was thought to involve the N-terminal microtubule-binding region of the major dynactin polypeptide p150(Glued), although recent results disputed this...
  25. Park A, Liegel R, Ronchetti A, Ebert A, Geurts A, Sidjanin D. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC Genet. 2014;15:135 pubmed publisher
    ..In addition to TBC1D20, mutations in RAB3GAP1, RAB3GAP2 and RAB18 cause WARBM1-3 respectively...
  26. Hosaka Y, Inoshita T, Shiba Fukushima K, Cui C, Arano T, Imai Y, et al. Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome. EBioMedicine. 2017;21:218-227 pubmed publisher
    Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra...
  27. Dumas A, Lê Bury G, Marie Anaïs F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed publisher
    ..Our data reveal that Vpr interacted with EB1, p150(Glued), and dynein heavy chain and was sufficient to critically alter the microtubule plus end localization of EB1 ..
  28. Liu X, Huang K, Hou Q, Sun Z, Wang B, Lin G, et al. Identification and characterization of a constitutively expressed Ctenopharyngodon idella ADAR1 splicing isoform (CiADAR1a). Dev Comp Immunol. 2016;63:10-7 pubmed publisher
    ..There are many ADAR1 splicing isoforms in mammals, including an interferon (IFN) inducible ?150 kD protein (ADAR1-p150) and a constitutively expressed ?110 kD protein (ADAR1-p110)...
  29. Yu J, Lai C, Shim H, Xie C, Sun L, Long C, et al. Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice. Mol Neurodegener. 2018;13:10 pubmed publisher
    Dynactin p150Glued, the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and basic domains, ..
  30. Kläning E, Christensen B, Bajic G, Hoffmann S, Jones N, Callesen M, et al. Multiple low-affinity interactions support binding of human osteopontin to integrin αXβ2. Biochim Biophys Acta. 2015;1854:930-8 pubmed publisher
    Integrin α(X)β(2) (also known as complement receptor 4, p150,95, or CD11c/CD18) is expressed in the cell membrane of myeloid leukocytes...
  31. Cegin M, Soyoral L, Yuzkat N, Baydi V, Goktas U. Pregabalin administered as an anxiolytic agent in ultrasound-guided infraclavicular block: a controlled, double-blind, dose-ranging trial. Eur Rev Med Pharmacol Sci. 2016;20:568-74 pubmed
    ..75 mg pregabalin per os was named Group P75, the group that received 150 mg pregabalin per os was named Group P150, and the group that received 300 mg pregabalin per os was named Group P300...
  32. Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov A, Wickramasinghe J, et al. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nat Struct Mol Biol. 2017;24:534-543 pubmed publisher
    Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates MDA5-MAVS-IFN signaling in the cytoplasm...
  33. Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, et al. PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex. Proc Natl Acad Sci U S A. 2016;113:E2955-64 pubmed publisher
    ..to control microtubules, likely by regulating the binding of accessory proteins including the dynactin subunit p150(glued) Consistent with this notion, we found that PDK1 regulates the expression of cytoplasmic dynein intermediate ..
  34. Fogerty J, Denton K, Perkins B. Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization. Adv Exp Med Biol. 2016;854:209-15 pubmed publisher
    ..and mike oko mutants, which carry mutations in the heavy chain subunit of cytoplasmic dynein 1 (dync1h1) and the p150(Glued) subunit of Dynactin (dctn1a)...
  35. Ramos Goicoa M, Galdo Alvarez S, Diaz F, Zurrón M. Effect of Normal Aging and of Mild Cognitive Impairment on Event-Related Potentials to a Stroop Color-Word Task. J Alzheimers Dis. 2016;52:1487-501 pubmed publisher
    ..Aging was associated with a) slowing of the neural processing of the stimuli (P150, N2, and P3b latencies were longer), b) greater activation of the motor cortex for response preparation (LRP-R ..
  36. Gustavsson E, Trinh J, Guella I, Szu Tu C, Khinda J, Lin C, et al. DCTN1 p.K56R in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016;28:56-61 pubmed publisher
    Mutations in dynactin DCTN1 (p150(glued)) have previously been linked to familial motor neuron disease or Perry syndrome (PS) consisting of depression, parkinsonism and hypoventilation...
  37. Lee S, Ou D, Lee C, Juan L. Gene-specific transcriptional activation mediated by the p150 subunit of the chromatin assembly factor 1. J Biol Chem. 2009;284:14040-9 pubmed publisher
    Chromatin assembly factor 1 contains three subunits, p150, p60, and p48. It is essential for coupling nucleosome assembly to newly synthesized DNA...
  38. Mishima T, Deshimaru M, Watanabe T, Kubota K, Kinoshita Kawada M, Yuasa Kawada J, et al. Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome. Neurosci Lett. 2018;666:98-103 pubmed publisher
    ..These included G71A in the microtubule-binding cytoskeleton-associated protein Gly-rich domain of p150Glued...
  39. Proikas Cezanne T, Takacs Z, Dönnes P, Kohlbacher O. WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome. J Cell Sci. 2015;128:207-17 pubmed publisher
    ..PtdIns3P) by phosphatidylinositol 3-kinase class III (PI3KC3, also known as PIK3C3) in complex with beclin 1, p150 (also known as PIK3R4; Vps15 in yeast) and ATG14L...
  40. Verissimo F, Halavatyi A, Pepperkok R, Weiss M. A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites. J Cell Sci. 2015;128:4160-70 pubmed publisher
    ..By performing fluorescence recovery after photobleaching (FRAP) and mathematical modeling, we show that p150(glued) (also known as DCTN1), a component of the dynactin complex, stabilizes the COPII pre-budding complex on ER ..
  41. Rohatgi R, Janusis J, Leonard D, Bellvé K, Fogarty K, Baehrecke E, et al. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015;34:5352-62 pubmed publisher
    ..component of the vacuolar protein sorting 34 (Vps34)/class III phosphatidylinositoI-3 kinase (PI3KC3) and Vps15/p150 complex that regulates multiple membrane-trafficking events...
  42. Pakdel A, Mounier C, Klein E, Hleibieh K, Monsion B, Mutterer J, et al. On the interaction and localization of the beet necrotic yellow vein virus replicase. Virus Res. 2015;196:94-104 pubmed publisher
    ..BNYVV RNA-1 encodes a non-structural p237 polyprotein processed in two proteins (p150 and p66) by a cis-acting protease activity...
  43. Schenk S, Minda J, Lech R, Suchan B. Out of sight, out of mind: Categorization learning and normal aging. Neuropsychologia. 2016;91:222-233 pubmed publisher
    ..The categorization of exceptions was accompanied by higher P150, P250 and P300 amplitudes...
  44. Galipon J, Ishii R, Suzuki Y, Tomita M, Ui Tei K. Differential Binding of Three Major Human ADAR Isoforms to Coding and Long Non-Coding Transcripts. Genes (Basel). 2017;8: pubmed publisher
    ..In humans, it is carried out by no less than three major adenosine deaminases acting on RNA (ADARs): ADAR1-p150, ADAR1-p110, and ADAR2...
  45. Handley M, Carpanini S, Mali G, Sidjanin D, Aligianis I, Jackson I, et al. Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation. Open Biol. 2015;5:150047 pubmed publisher
    RAB18, RAB3GAP1, RAB3GAP2 and TBC1D20 are each mutated in Warburg Micro syndrome, a rare autosomal recessive multisystem disorder...
  46. Uwada J, Tanaka N, Yamaguchi Y, Uchimura Y, Shibahara K, Nakao M, et al. The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci. Biochem Biophys Res Commun. 2010;391:407-13 pubmed publisher
    ..Here we report that the largest subunit of chromatin assembly factor 1 (CAF-1), human p150, interacts directly and preferentially with SUMO2/3...
  47. Vergara Martínez M, Gómez P, Jiménez M, Perea M. Lexical enhancement during prime-target integration: ERP evidence from matched-case identity priming. Cogn Affect Behav Neurosci. 2015;15:492-504 pubmed publisher
    ..The ERP waves revealed that matched-case identity-priming effects were found at a very early time epoch (N/P150 effects) for words and pseudowords...
  48. Pinedo P, Melendez P, Paudyal S, Krauss R, Arias F, Lopez H, et al. Association between disease occurrence and fertility of dairy cows in three geographic regions of Chile. Theriogenology. 2016;86:817-23 pubmed publisher
    ..The odds (95% confidence interval) of pregnancy at 150 DIM (P150) and the odds of survival until 150 DIM (S150) for cows that had at least one disease event within 50 DIM were 0...
  49. Yang C, Sengupta S, Hegde P, Mitra J, Jiang S, Holey B, et al. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic Acids Res. 2017;45:739-748 pubmed publisher
    ..Here we show that chromatin assembly factor (CAF)-1 subunit A (CHAF1A), the p150 subunit of the histone H3/H4 chaperone, and its partner anti-silencing function protein 1A (ASF1A), which we ..
  50. Reese B, Bachman K, Baylin S, Rountree M. The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. Mol Cell Biol. 2003;23:3226-36 pubmed
    ..In this study, we demonstrate that MBD1 partners with the p150 subunit of chromatin assembly factor 1 (CAF-1), forming a multiprotein complex that also contains HP1alpha...
  51. Ayloo S, Lazarus J, Dodda A, Tokito M, Ostap E, Holzbaur E. Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat Commun. 2014;5:4807 pubmed publisher
    ..Here we use single molecule approaches to investigate dynein regulation by the dynactin subunit p150(Glued)...
  52. Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, et al. Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Hum Mol Genet. 2015;24:2228-40 pubmed publisher
    ..Here, we show that a mouse model expressing low levels of disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is ..
  53. Sainath R, Armijo Weingart L, Ketscheck A, Xu Z, Li S, Gallo G. Chondroitin sulfate proteoglycans negatively regulate the positioning of mitochondria and endoplasmic reticulum to distal axons. Dev Neurobiol. 2017;77:1351-1370 pubmed publisher
    ..CSPGs elevate the levels of p150Glu dynactin found in distal axons, and inhibition of the interaction of dynactin with dynein increased ..
  54. Sedlmeier A, Kluttig A, Giegling I, Prehn C, Adamski J, Kastenmüller G, et al. The human metabolic profile reflects macro- and micronutrient intake distinctly according to fasting time. Sci Rep. 2018;8:12262 pubmed publisher
    ..Concentrations of 134 serum metabolites were measured by targeted metabolomics AbsoluteIDQ p150 Kit...
  55. Wu Z, Cui F, Yu F, Peng X, Jiang T, Chen D, et al. Up-regulation of CHAF1A, a poor prognostic factor, facilitates cell proliferation of colon cancer. Biochem Biophys Res Commun. 2014;449:208-15 pubmed publisher
    Deregulation of chromatin assembly factor 1, p150 subunit A (CHAF1A) has recently been reported to be involved in the development of some cancer types...
  56. Tan Z, Liu R, Zheng L, Hao S, Fu C, Li Z, et al. Cerebrospinal fluid protein dynamic driver network: At the crossroads of brain tumorigenesis. Methods. 2015;83:36-43 pubmed publisher
    ..CSF proteomics changes were quantified at approximately 30, 60, 90, 120, 150 days of age (P30, P60, P90, P120, P150)...
  57. Sharadamma N, Harshavardhana Y, Ravishankar A, Anand P, Chandra N, Muniyappa K. Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction. Biochemistry. 2015;54:4142-60 pubmed publisher
    ..the presence of Arg170, Arg171, and Arg173, which might be involved in DNA binding, and a conserved proline (P150) in the tight turn...
  58. Matheson T, Kaufman P. Grabbing the genome by the NADs. Chromosoma. 2016;125:361-71 pubmed publisher
    ..including the insulator protein CCCTC-binding factor (CTCF), chromatin assembly factor (CAF)-1 subunit p150, several nucleolar proteins, and two long non-coding RNAs (lncRNAs)...
  59. Lacruz M, Kluttig A, Tiller D, Medenwald D, Giegling I, Rujescu D, et al. Cardiovascular Risk Factors Associated With Blood Metabolite Concentrations and Their Alterations During a 4-Year Period in a Population-Based Cohort. Circ Cardiovasc Genet. 2016;9:487-494 pubmed publisher
    ..One hundred and sixty-three metabolites were measured in serum samples with the AbsoluteIDQ kit p150 (Biocrates) following a targeted metabolomics approach, in a population-based cohort of 1030 individuals, aged 45 ..
  60. Heep M, Mach P, Reautschnig P, Wettengel J, Stafforst T. Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing. Genes (Basel). 2017;8: pubmed publisher
    ..the current guideRNA design is already able to recruit another human deaminase, ADAR1, in both isoforms, p110 and p150. However, further optimization seems necessary as the current design is less efficient for ADAR1 isoforms...
  61. Montes de Oca R, Gurard Levin Z, Berger F, Rehman H, Martel E, Corpet A, et al. The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma. Mol Oncol. 2015;9:657-74 pubmed publisher
    ..Several chromatin regulators, including the histone chaperones CAF-1 (subunits p150 and p60), ASF1b, and HJURP, and the centromeric histone variant CENP-A, associated with local and metastatic ..
  62. Hantan D, Yamamoto Y, Sakisaka T. VAP-B binds to Rab3GAP1 at the ER: its implication in nuclear envelope formation through the ER-Golgi intermediate compartment. Kobe J Med Sci. 2014;60:E48-56 pubmed
    ..Rab3GAP consists of two subunits, the catalytic subunit Rab3GAP1 and the non-catalytic subunit Rab3GAP2. VAP-B binds to Rab3GAP1 even in the Rab3GAP1/2 heterodimer complex...
  63. Chen T, Syu J, Han T, Cheng H, Lu F, Wang C. Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome. J Cell Biochem. 2015;116:2049-60 pubmed publisher
    b>p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein...
  64. Volk A, Crispino J. The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease. Biochim Biophys Acta. 2015;1849:979-86 pubmed publisher
    ..Whereas the diverse functions of the large (CAF-1-p150, CHAF1a) and small (RbAp48, p48) subunits of the CAF-1 complex have been well-characterized in many tissues and ..
  65. Fujita N, Tobe M, Tsukamoto N, Saito S, Obata H. A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery. J Clin Anesth. 2016;31:149-53 pubmed publisher
    ..randomly assigned to receive diazepam 5 mg as an active placebo (D5), pregabalin 75 mg (P75), or pregabalin 150 mg (P150). The study drug was orally administered 2 hours prior to surgery and a standard anesthetic technique was used...
  66. Xu M, Jia Y, Liu Z, Ding L, Tian R, Gu H, et al. Chromatin assembly factor 1, subunit A (P150) facilitates cell proliferation in human hepatocellular carcinoma. Onco Targets Ther. 2016;9:4023-35 pubmed publisher
    Several studies have revealed that the abnormal expression of chromatin assembly factor 1, subunit A (P150) (CHAF1A) was involved in the development of some types of malignant tumors...
  67. Reddy B, Mattson M, Wynne C, Vadpey O, Durra A, Chapman D, et al. Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro. Nat Commun. 2016;7:12259 pubmed publisher
    ..blocked by RNAi for the cytoplasmic dynein regulators LIS1 and NudE/L (Nde1/Ndel1), but not for the dynactin p150(Glued) subunit...
  68. Li K, Yang L, Zhang C, Niu Y, Li W, Liu J. HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes. J Cell Sci. 2014;127:4574-88 pubmed publisher
    ..Here, we demonstrate that HPS6 directly interacts with the dynactin p150(Glued) subunit of the dynein-dynactin motor complex and acts as cargo adaptor for the retrograde motor to mediate ..
  69. Kirov H, Schwarzer M, Neugebauer S, Faerber G, Diab M, Doenst T. Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery. BMC Cardiovasc Disord. 2017;17:93 pubmed publisher
    ..15 sphingolipids, sugars, lactate) using a mass-spectrometry-based kit (Biocrates AbsoluteIDQ® p150) in paired arterial and coronary sinus blood obtained from 10 consecutive On-Pump and 10 Off-Pump patients...
  70. Picker Minh S, Busche A, Hartmann B, Spors B, Klopocki E, Hübner C, et al. Large homozygous RAB3GAP1 gene microdeletion causes Warburg micro syndrome 1. Orphanet J Rare Dis. 2014;9:113 pubmed publisher
    ..WARBM1-4 can be caused by biallelic mutations of the RAB3GAP1 (RAB3 GTPase-activating protein 1), RAB3GAP2, RAB18 (RAS-associated protein RAB18), or TBC1D20 (TBC1 domain protein, member 20) gene, respectively...
  71. Pestal K, Funk C, Snyder J, Price N, Treuting P, Stetson D. Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development. Immunity. 2015;43:933-44 pubmed publisher
    ..We showed that the p150 isoform of ADAR1 uniquely regulated the MDA5 pathway, whereas both the p150 and p110 isoforms contributed to ..
  72. Matheson T, Kaufman P. The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer. Mol Biol Cell. 2017;28:21-29 pubmed publisher
    Chromatin assembly factor 1 (CAF-1) deposits histones during DNA synthesis. The p150 subunit of human CAF-1 contains an N-terminal domain (p150N) that is dispensable for histone deposition but promotes the localization of specific loci (..
  73. Rolef Ben Shahar T, Castillo A, Osborne M, Borden K, Kornblatt J, Verreault A. Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function. Mol Cell Biol. 2009;29:6353-65 pubmed publisher
    ..Here we report that the large subunit of human CAF-1 (p150) contains two distinct PCNA interaction peptides (PIPs)...
  74. Cachat A, Alais S, Chevalier S, Journo C, Fusil F, Dutartre H, et al. ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity. Retrovirology. 2014;11:93 pubmed publisher
    ..ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that can edit viral RNAs...
  75. Sung C, Yim H. The tumor suppressor protein p150(Sal2) in carcinogenesis. Tumour Biol. 2015;36:489-94 pubmed publisher
    The transcription factor p150(Sal2), the product of the SALL2 gene, was first identified as a binding target of the oncogenic mouse polyomavirus T antigen...
  76. Hetta D, Mohamed M, Mohammad M. Analgesic efficacy of pregabalin in acute postmastectomy pain: placebo controlled dose ranging study. J Clin Anesth. 2016;34:303-9 pubmed publisher
    ..The VAS score at rest and movement was significantly decreased only in group P300 and group P150 in comparison to group P0 and group P75 at 0 hour (P<.01)...
  77. Watson P, Stephens D. Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. J Cell Sci. 2006;119:2758-67 pubmed
    ..a family of proteins that localize to microtubule plus-ends, and include EB1, CLIP-170 and the dynactin component p150(Glued)...
  78. Liegel R, Handley M, Ronchetti A, Brown S, Langemeyer L, Linford A, et al. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet. 2013;93:1001-14 pubmed publisher
    ..a spectrum of disorders characterized by eye, brain, and endocrine abnormalities caused by mutations in RAB3GAP1, RAB3GAP2, and RAB18...
  79. Otte R, Donkers F, Braeken M, Van den Bergh B. Multimodal processing of emotional information in 9-month-old infants II: prenatal exposure to maternal anxiety. Brain Cogn. 2015;95:107-17 pubmed publisher
    ..A trend for a positive association between P150 amplitudes and maternal anxiety scores during pregnancy may suggest these infants are more easily aroused by and ..
  80. George C, Samuel C. STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1. Virology. 2015;485:363-70 pubmed publisher
    ..Promoter PA, activated by interferon (IFN), produces transcripts that encode the inducible p150 ADAR1 protein, whereas PB specifies the constitutively expressed p110 protein...
  81. Segura F, Sánchez Cano A, Jarabo S, López de la Fuente C, Cuenca N, Villegas Pérez M, et al. Assessment of Visual and Chromatic Functions in a Rodent Model of Retinal Degeneration. Invest Ophthalmol Vis Sci. 2015;56:6275-83 pubmed publisher
    ..Pigmented P23H rats were studied by optomotor testing and electroretinogram (ERG) recordings at P30, P150, and P240. Pigmented LE rats were used as a normal wild-type control. Stimuli were modified with colored filters...
  82. Fokin A, Klementeva T, Nadezhdina E, Burakov A. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. Cytoskeleton (Hoboken). 2016;73:83-92 pubmed publisher
    ..regulator of cell locomotion that primarily acts through the small GTPase RhoA and the dynactin subunit p150(Glued)...
  83. McKenney R, Huynh W, Vale R, Sirajuddin M. Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016;35:1175-85 pubmed publisher
    ..This preference is mediated by dynactin's microtubule-binding p150 subunit rather than dynein itself...
  84. Nath S, Christian L, Tan S, Ki S, Ehrlich L, Poenie M. Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion. J Immunol. 2016;197:2090-101 pubmed publisher
    ..we show that the dynein-binding proteins nuclear distribution E homolog 1 (NDE1) and dynactin (as represented by p150(Glued)) form mutually exclusive complexes with dynein, exhibit nonoverlapping distributions in target-stimulated ..
  85. Smylla T, Preiss A, Maier D. In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila. Sci Rep. 2016;6:34881 pubmed publisher
    ..ribosome entry site in the full length H transcript resulting in two H protein isoforms (Hp120 and Hp150). Hence, H may repress Notch signalling activity in situations where cap-dependent translation is inhibited...
  86. Park S, Kang M, Choi Y, Kim Y, Antika L, Kim D, et al. α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. Oncotarget. 2017;8:7370-7383 pubmed publisher
    ..this compound promoted the induction of the key autophagic proteins of beclin-1, vacuolar protein sorting 34 and p150 responsible for vesicle nucleation, and prompted the conversion of microtubule-associated protein 1A/1B-light chain ..
  87. Farshidfar F, Kopciuk K, Hilsden R, McGregor S, Mazurak V, Buie W, et al. A quantitative multimodal metabolomic assay for colorectal cancer. BMC Cancer. 2018;18:26 pubmed publisher
    ..The well-characterized Biocrates P150 kit was used to quantify 163 metabolites in patients with CRC (N = 62), adenoma (N = 31), and age- and gender-..
  88. Echbarthi M, Vallin J, Grantham J. Interactions between monomeric CCT? and p150Glued: A novel function for CCT? at the cell periphery distinct from the protein folding activity of the molecular chaperone CCT. Exp Cell Res. 2018;370:137-149 pubmed publisher
    ..Here, using a yeast two-hybrid screen we identify the dynactin complex component p150Glued as a binding partner for CCT? and show by siRNA depletion that this interaction is required for the ..
  89. Poleshko A, Einarson M, Shalginskikh N, Zhang R, Adams P, Skalka A, et al. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. 2010;285:422-33 pubmed publisher
    ..detected for two TRIM protein family members, the cohesin component Rad21, and the histone chaperone CHAF1A (CAF-1 p150)...
  90. Fransen J, Pangeni G, Pyle I, McCall M. Functional changes in Tg P23H-1 rat retinal responses: differences between ON and OFF pathway transmission to the superior colliculus. J Neurophysiol. 2015;114:2368-75 pubmed publisher
    ..At P150, metabotropic glutamate receptor 6 (mGluR6) expression is lower than in WT, consistent with a decrease in ON RGC ..
  91. Rostislavleva K, Soler N, Ohashi Y, Zhang L, Pardon E, Burke J, et al. Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science. 2015;350:aac7365 pubmed publisher
    ..4 angstrom crystal structure of the 385-kilodalton endosomal complex II (PIK3C3-CII), consisting of Vps34, Vps15 (p150), Vps30/Atg6 (Beclin 1), and Vps38 (UVRAG). The subunits form a Y-shaped complex, centered on the Vps34 C2 domain...
  92. Sung C, Yim H. Roles of SALL2 in tumorigenesis. Arch Pharm Res. 2017;40:146-151 pubmed publisher
    The proteins p150Sal2 (product of SALL2) and p53 share growth arrest and pro-apoptotic functions by independently inducing p21Cip1/Waf1 and BAX, and both proteins are targeted by the human papilloma virus E6 protein, ..