RAB3D

Summary

Gene Symbol: RAB3D
Description: RAB3D, member RAS oncogene family
Alias: D2-2, GOV, RAB16, RAD3D, ras-related protein Rab-3D, Rab3D upregulated with myeloid differentiation, glioblastoma overexpressed
Species: human
Products:     RAB3D

Top Publications

  1. Pavlos N, Cheng T, Qin A, Ng P, Feng H, Ang E, et al. Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol Cell Biol. 2011;31:1551-64 pubmed publisher
    ..However, the molecular mechanisms bridging these vesicle-microtubule interactions remain largely obscure. Rab3D, a member of the Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases, represents a core component of the ..
  2. Riedel D, Antonin W, Fernandez Chacon R, Alvarez de Toledo G, Jo T, Geppert M, et al. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol. 2002;22:6487-97 pubmed
    b>Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as on secretory vesicles in mast cells and in the parotid gland...
  3. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, et al. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004;101:8313-8 pubmed
    ..Thus, Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. ..
  4. Joo J, Lee Y, Song S. OsbZIP42 is a positive regulator of ABA signaling and confers drought tolerance to rice. Planta. 2019;249:1521-1533 pubmed publisher
    ..rice overexpressing OsbZIP42 (OsbZIP42-OX) exhibited a rapidly elevated expression of the ABA-responsive LEA3 and Rab16 genes and was hypersensitive to ABA...
  5. Limi S, OJAKIAN G, Raffaniello R. Rab3D regulates amylase levels, not agonist-induced amylase release, in AR42J cells. Cell Mol Biol Lett. 2012;17:258-73 pubmed publisher
    b>Rab3D is a low molecular weight GTP-binding protein that associates with secretory granules in exocrine cells...
  6. Ju Y, Janga S, Klinngam W, MacKay J, Hawley D, Zoukhri D, et al. NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res. 2018;176:243-251 pubmed publisher
    ..Redistribution of the secretory effector, Rab3D in acinar cells was observed at both time points in NOD and NOR, but thinning of myoepithelial cells at 12 weeks ..
  7. Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van Den Broecke R, et al. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst. 2010;102:866-80 pubmed publisher
    ..METHODS Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP binding or geranylgeranylation, or transient ..
  8. Hou Y, Ernst S, Stuenkel E, Lentz S, Williams J. Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion. PLoS ONE. 2015;10:e0125596 pubmed publisher
    ..Compared to wild-type, expression of Rab27B was slightly increased in ashen mouse acini, while Rab3D and digestive enzymes (amylase, lipase, chymotrypsin and elastase) were not affected...
  9. Ishikawa T, Takizawa T, Iwaki J, Mishima T, Ui Tei K, Takeshita T, et al. Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells. Int J Mol Med. 2015;35:1273-89 pubmed publisher
    ..Among the RABs, RAB3D was expressed predominantly in placental endothelial cells...

More Information

Publications40

  1. Weis V, Petersen C, Mills J, Tuma P, Whitehead R, Goldenring J. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol. 2014;307:G777-92 pubmed publisher
    ..ImChief cells transcriptionally express most chief cell markers and contain pepsinogen C and RAB3D-immunostaining vesicles. ImSPEM cells express the SPEM markers TFF2 and HE4 and constitutively secrete HE4...
  2. Meng Z, Edman M, Hsueh P, Chen C, Klinngam W, Tolmachova T, et al. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016;310:C942-54 pubmed publisher
    ..Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC...
  3. Xie K, Chen M, Zhu M, Wang C, Qin N, Liang C, et al. A polymorphism in miR-1262 regulatory region confers the risk of lung cancer in Chinese population. Int J Cancer. 2017;141:958-966 pubmed publisher
    ..of miR-1262 inhibited lung cancer cell proliferation probably through targeting the expression levels of ULK1 and RAB3D. Our findings confirmed the important role that genetic variants of noncoding sequence play in lung cancer ..
  4. Merino Gracia J, García Mayoral M, Rapali P, Valero R, Bruix M, Rodríguez Crespo I. DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor. FEBS J. 2015;282:3945-58 pubmed publisher
    ..Recent data showed that DYNLT links the small GTPase Rab3D to microtubules and, for this to occur, the DYNLT homodimer needs to display a binding site for dynein ..
  5. Shrestha B, Karki H, Groth D, Jungkhun N, Ham J. Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice. PLoS ONE. 2016;11:e0146764 pubmed publisher
    ..The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B. amyloliquefaciens in DNA sequence of 16S rDNA and gyrB, but to B...
  6. Rasineni K, Penrice D, Natarajan S, McNiven M, McVicker B, Kharbanda K, et al. Alcoholic vs non-alcoholic fatty liver in rats: distinct differences in endocytosis and vesicle trafficking despite similar pathology. BMC Gastroenterol. 2016;16:27 pubmed publisher
    ..of (125)I- asialoorosomucoid) was measured in isolated hepatocytes, and content of selected trafficking proteins (Rab3D, Rab7 and Rab18) were determined in whole liver tissue...
  7. Hou Y, Ernst S, Lentz S, Williams J. Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. Biochem Biophys Res Commun. 2016;471:610-5 pubmed publisher
    ..g. similar small G proteins, such as Rab3D and Rab27A, and putative downstream effectors...
  8. Merino Gracia J, Zamora Carreras H, Bruix M, Rodríguez Crespo I. Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB. J Biol Chem. 2016;291:20962-20975 pubmed
    ..subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPases RagA and Rab3D. Although over 20 DYNLT1-interacting proteins have been reported, the exact sequence requirements that enable ..
  9. Massie I, Spaniol K, Geerling G, Schrader S. Cryopreservation and hypothermic storage of lacrimal gland: towards enabling delivery of regenerative medicine therapies for treatment of dry eye syndrome. J Tissue Eng Regen Med. 2017;11:3373-3384 pubmed publisher
    ..P1, epithelial cells from fresh and stored tissue were largely equivalent in terms of: proliferation; CFE (~21%); Rab3D, HexA and lysozyme expression; mucin production; and ?-hexosaminidase activity...
  10. Luo Y, Ye G, Qin S, Mu Y, Zhang L, Qi Y, et al. High expression of Rab3D predicts poor prognosis and associates with tumor progression in colorectal cancer. Int J Biochem Cell Biol. 2016;75:53-62 pubmed publisher
    b>Rab3D belongs to Rab protein family. Previous reports showed that the expression of Rab3D was dysregulated in various types of cancer. Rab3D belongsRab3D belongs...
  11. Yang J, Wu C, Stefănescu I, Jakobsson L, Chervoneva I, Horowitz A. RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms. Sci Signal. 2016;9:ra76 pubmed publisher
    ..Furthermore, less Noggin and fewer vesicles containing Rab3d, a GTPase that mediates Noggin trafficking, were detected in cells from Syx(-/-) embryoid bodies, which could ..
  12. Cartel N, Wang J, Post M. Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. Biochem J. 2002;363:19-28 pubmed
    ..Furthermore, expression of dominant-negative Akt abrogated endogenous Akt activity, Rab3D phosphorylation and GAG synthesis, whereas expression of constitutively activated Akt stimulated Rab3D ..
  13. Tian X, Jin R, Bredemeyer A, Oates E, Błazewska K, McKenna C, et al. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Mol Cell Biol. 2010;30:1269-84 pubmed publisher
    ..CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. We next show that RAB26 and RAB3D expression is significantly downregulated in Mist1(-)(/)(-) ZCs, suggesting ..
  14. Raffaniello R, Raufman J. Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach. J Cell Biochem. 1999;72:540-8 pubmed
    b>Rab3D, a low-molecular-weight GTP-binding protein believed to be involved with regulated exocytosis, is associated with secretory granules in gastric chief cells...
  15. Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell. 2008;19:2916-25 pubmed publisher
    ..In addition, overexpression of the Rab33B binding domain of Atg16L suppressed autophagosome formation. Our findings suggest that Rab33 modulates autophagosome formation through interaction with Atg16L. ..
  16. Zhang J, Kong R, Sun L. Silencing of Rab3D suppresses the proliferation and invasion of esophageal squamous cell carcinoma cells. Biomed Pharmacother. 2017;91:402-407 pubmed publisher
    b>Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer...
  17. Gomi H, Osawa H, Uno R, Yasui T, Hosaka M, Torii S, et al. Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties. J Histochem Cytochem. 2017;65:637-653 pubmed publisher
    ..Similarly, Rab proteins (Rab3d, Rab11a, Rab11b, Rab27a, and Rab27b) and soluble N-ethylmaleimide-sensitive fusion protein attachment protein ..
  18. Yasui T, Gomi H, Kitahara T, Tsukise A. Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands. Eur J Histochem. 2017;61:2828 pubmed publisher
    ..of the ceruminous glands in goats, our study focuses on the demonstration of β-defensins, SNARE proteins and Rab3D in these glands with the use of immunohistochemical methods...
  19. Kogel T, Rudolf R, Hodneland E, Copier J, Regazzi R, Tooze S, et al. Rab3D is critical for secretory granule maturation in PC12 cells. PLoS ONE. 2013;8:e57321 pubmed publisher
    ..Our data show that the presence of Rab3D(N135I) decreases the restriction of maturing SGs to the F-actin-rich cell cortex, blocks the removal of the ..
  20. Bahamondes V, Albornoz A, Aguilera S, Alliende C, Molina C, Castro I, et al. Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction. Arthritis Rheum. 2011;63:3126-35 pubmed publisher
    ..This study was undertaken to analyze the expression and localization of Rab3D and Rab8A and to examine their correlation with acinar cell polarity and glandular secretory function...
  21. Knop M, Aareskjold E, Bode G, Gerke V. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. EMBO J. 2004;23:2982-92 pubmed
    ..could regulate differentially the release of pro- and antithrombogenic factors, we analyzed the contribution of Rab3D and the annexin A2/S100A10 complex, proteins implicated in exocytotic events in other systems...
  22. Nishio H, Suda T, Sawada K, Miyamoto T, Koike T, Yamaguchi Y. Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. Biochim Biophys Acta. 1999;1444:283-90 pubmed
    ..of this clone with Rab proteins revealed that it had highest homology to a small GTP-binding protein, murine Rab3D. The mRNA expression of human Rab3D was upregulated in the course of myeloid differentiation, and it was ..
  23. Yang J, Liu W, Lu X, Fu Y, Li L, Luo Y. High expression of small GTPase Rab3D promotes cancer progression and metastasis. Oncotarget. 2015;6:11125-38 pubmed
    ..As a secretory small GTPase, Rab3D is a vital regulator for protein secretion. However, the role of Rab3D in cancer was never systematically studied...
  24. Chen X, Shi Z, Korenberg J, Sehgal A. Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1998;83:230-1 pubmed
  25. Brondyk W, McKiernan C, Fortner K, Stabila P, Holz R, Macara I. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Mol Cell Biol. 1995;15:1137-43 pubmed
    ..a rat brain cDNA encoding a novel 50-kDa protein, which we have named Rabin3, that interacts with Rab3A and Rab3D but not with other small GTPases (Rab3C, Rab2, Ran, or Ras)...
  26. Lindsay A, Jollivet F, Horgan C, Khan A, Raposo G, McCaffrey M, et al. Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell. 2013;24:3420-34 pubmed publisher
    ..We also present evidence that myosin Va is necessary for maintaining a peripheral distribution of Rab11- and Rab14-positive endosomes. ..
  27. Zografou S, Basagiannis D, Papafotika A, Shirakawa R, Horiuchi H, Auerbach D, et al. A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis. J Cell Sci. 2012;125:4780-90 pubmed publisher
    ..Yet, the only known WPB-associated Rabs are Rab27a and Rab3d. To determine the full spectrum of WPB-associated Rabs we performed a complete Rab screening by analysing the ..
  28. Breen E, Malloy J, Tang K, Xia F, Fu Z, Hancock R, et al. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013;228:371-9 pubmed publisher
    ..PL), DSPC, DSPC synthesis, surfactant associated proteins (SP)-B and -D, and the lipid transporters, ABCA1 and Rab3D. TPA-induced DSPC secretion and apoptosis were elevated in VEGF-deficient type II cells...
  29. Shah F, Goossens E, Atallah N, Grimard M, Kelley M, Fishel M. APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing. Mol Oncol. 2017;11:1711-1732 pubmed publisher
    ..Testing additional patient-derived pancreatic cancer cells reveals particular genes (ITGA1, TNFAIP2, COMMD7, RAB3D) that respond to APE1 knockdown similarly across all the cell lines...
  30. Nguyen D, Jones A, Ojakian G, Raffaniello R, Ngyen D. Rab3D redistribution and function in rat parotid acini. J Cell Physiol. 2003;197:400-8 pubmed
    b>Rab3D is a low molecular weight GTP-binding protein believed to be involved with regulated secretion in many cell types...
  31. Sehgal A, Keener C, Boynton A, Young R, Vermeulen S, Yonemura K, et al. Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue. Int J Cancer. 1997;71:565-72 pubmed
    ..We also show that D2-2 is expressed 28-fold higher in fetal brain (20 weeks) than in adult brain. Sequence analysis of a 2.0-kb fragment for D2-2 shows no homology to known sequences in the data base. ..