RAB2A

Summary

Gene Symbol: RAB2A
Description: RAB2A, member RAS oncogene family
Alias: LHX, RAB2, ras-related protein Rab-2A, RAB2, member RAS oncogene family, small GTP binding protein RAB2A
Species: human
Products:     RAB2A

Top Publications

  1. Sato K, Roboti P, Mironov A, Lowe M. Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210. Mol Biol Cell. 2015;26:537-53 pubmed publisher
    ..Binding to Rab2 is also important for GMAP-210 function, although it is dispensable for tethering per se...
  2. Nourashrafeddin S, Aarabi M, Modarressi M, Rahmati M, Nouri M. The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer. Pathol Oncol Res. 2015;21:293-300 pubmed publisher
    ..yes-associated protein-1 (YAP1), WW domain containing transcription regulator (WWTR1), member RAS oncogene family (RAB2A), and small G protein signaling modulator 3 (SGSM3)...
  3. Chow C, Wolfner M, Clark A. Large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics. 2013;193:177-85 pubmed publisher
    ..Knockdown studies of three candidate genes (para, Rab2, and Rim) in sensory neurons innervating the female reproductive tract indicate that some of these candidate female ..
  4. Tamura N, Mima J. Membrane-anchored human Rab GTPases directly mediate membrane tethering in vitro. Biol Open. 2014;3:1108-15 pubmed publisher
    ..Strikingly, we found that three specific human Rabs (endoplasmic reticulum/Golgi Rab2a, early endosomal Rab5a, and late endosomal/lysosomal Rab7a) strongly accelerated membrane aggregation of synthetic ..
  5. Maringer K, Saheb E, Bush J. Vesicular Trafficking Defects, Developmental Abnormalities, and Alterations in the Cellular Death Process Occur in Cell Lines that Over-Express Dictyostelium GTPase, Rab2, and Rab2 Mutants. Biology (Basel). 2014;3:514-35 pubmed publisher
    Small molecular weight GTPase Rab2 has been shown to be a resident of pre-Golgi intermediates and required for protein transport from the ER to the Golgi complex, however, the function of Rab2 in Dictyostelium has yet to be fully ..
  6. Liegel R, Handley M, Ronchetti A, Brown S, Langemeyer L, Linford A, et al. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet. 2013;93:1001-14 pubmed publisher
    ..Functional analysis established the mouse TBC1D20 protein as a GTPase-activating protein (GAP) for RAB1 and RAB2, and bs as a TBC1D20 loss-of-function mutation...
  7. Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, et al. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. J Genet Genomics. 2018;: pubmed publisher
    ..Our further analysis of the involvement of Rab-GTPases in secretion shows that Rab1, Rab2 and RabX3, are all required at ERES, each of them differentially affecting ERES morphology...
  8. Xinhong L, Zhen L, Fu J, Wang L, Yang Q, Li P, et al. Quantitative proteomic profiling indicates the difference in reproductive efficiency between Meishan and Duroc boar spermatozoa. Theriogenology. 2018;116:71-82 pubmed publisher
    ..Moreover, APOA1, NDUFS2 and RAB2A which are negatively related to farrowing rates, were less abundant in Meishan spermatozoa than in Duroc ..
  9. Gillingham A, Sinka R, Torres I, Lilley K, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358-73 pubmed publisher
    ..We confirm over 25 interactions for Rab2, Rab4, Rab5, Rab6, Rab7, Rab9, Rab18, Rab19, Rab30, and Rab39...

More Information

Publications61

  1. Sugawara T, Kano F, Murata M. Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells. Sci Rep. 2014;4:6952 pubmed publisher
    b>Rab2A, a small GTPase localizing to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), regulates COPI-dependent vesicular transport from the ERGIC...
  2. Kwon W, Rahman M, Lee J, Yoon S, Park Y, Pang M. Discovery of predictive biomarkers for litter size in boar spermatozoa. Mol Cell Proteomics. 2015;14:1230-40 pubmed publisher
    ..We also found that equatorin, spermadhesin AWN, triosephosphate isomerase (TPI), Ras-related protein Rab-2A (RAB2A), spermadhesin AQN-3, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUFS2) were significantly and ..
  3. Wang H, Zhang X, Zuo Z, Zhang Q, Pan Y, Zeng B, et al. Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells. J Immunol. 2017;198:3729-3736 pubmed publisher
    ..found that Rip2 is required for lysozyme sorting in Paneth cells in a manner that is dependent on Nod2, LRRK2, and Rab2a. Rip2 deficiency in mouse led to lysosomal degradation of lysozyme in Paneth cells and prevented the recruitment ..
  4. Puthiyedth N, Riveros C, Berretta R, Moscato P. Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions. PLoS ONE. 2016;11:e0152342 pubmed publisher
    ..Our study confirms the up-regualtion of INFAR2 and PTMA along with the down regulation of GPHN, RAB2A, PSMD14 and FGF...
  5. Sidjanin D, Park A, Ronchetti A, Martins J, Jackson W. TBC1D20 mediates autophagy as a key regulator of autophagosome maturation. Autophagy. 2016;12:1759-1775 pubmed
    ..Biochemical studies have established TBC1D20 as a GAP for RAB1B and RAB2A. However, the cellular role of TBC1D20 still remains elusive, and there is little information about how the ..
  6. Pisaneschi E, Sirleto P, Lepri F, Genovese S, Dentici M, Petrocchi S, et al. CHARGE syndrome due to deletion of region upstream of CHD7 gene START codon. BMC Med Genet. 2015;16:78 pubmed publisher
    ..we detected a microdeletion (184 kb) involving the promoter region and exon 1 of CHD7 gene and the flanking RAB2 gene...
  7. Aizawa M, Fukuda M. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. J Biol Chem. 2015;290:22250-61 pubmed publisher
    ..g. Rab2A, which is highly homologous to Rab2B, indicating that these Rab isoforms non-redundantly regulate Golgi morphology ..
  8. Maringer K, Yarbrough A, Sims Lucas S, Saheb E, Jawed S, Bush J. Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation. J Biosci. 2016;41:205-17 pubmed
    Small-molecular-weight GTPase Rab2 has been shown to be a resident of pre-Golgi intermediates and is required for protein transport from the ER to the Golgi complex; however, Rab2 has yet to be characterized in Dictyostelium discoideum...
  9. White J, Anderson E, Zimmerman K, Zheng K, Rouhani R, Gunawardena S. Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. Hum Mol Genet. 2015;24:7182-95 pubmed publisher
    ..Interestingly, reduction of HTT stimulated the anterograde motility of Rab2-containing vesicles...
  10. Galea G, Bexiga M, Panarella A, O Neill E, Simpson J. A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. J Cell Sci. 2015;128:2339-49 pubmed publisher
    ..In addition to demonstrating roles for Rab1a, Rab1b, Rab2a, and Rab6a or Rab6a' in this transport step, we also identified Rab10 and Rab11a as playing a role and being ..
  11. Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, et al. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol. 2015;16:918-26 pubmed publisher
    ..dense core vesicles (DCVs), which was required for DCV localization of LRRK2 and a small GTPase, Rab2a. Deficiency of Nod2, LRRK2 or Rab2a or depletion of commensals resulted in lysosomal degradation of lysozyme...
  12. Kwon W, Rahman M, Ryu D, Park Y, Pang M. Increased male fertility using fertility-related biomarkers. Sci Rep. 2015;5:15654 pubmed publisher
    ..hand, equatorin, beta-tubulin, cytochrome b-c1 complex subunit 1 (UQCRC1), speriolin, Ras-related protein Rab-2A (RAB2A), spermadhesin AQN-3, and seminal plasma sperm motility inhibitor were abundantly expressed in low-litter size ..
  13. Fujita N, Huang W, Lin T, Groulx J, Jean S, Nguyen J, et al. Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. elife. 2017;6: pubmed publisher
    ..Along with known mediators of autophagosome-lysosome fusion, our screens uncovered an unexpected shared role for Rab2 with a broadly conserved function in autophagic clearance...
  14. Liang W, Zheng M, Bao C, Zhang Y. CSFV proliferation is associated with GBF1 and Rab2. J Biosci. 2017;42:43-56 pubmed
    ..RNA interfering targets, such as the Golgi-specific BFA-resistance guanine nucleotide exchange factor 1 (GBF1) and Rab2 GTPases...
  15. Tisdale E, Talati N, Artalejo C, Shisheva A. GAPDH binds Akt to facilitate cargo transport in the early secretory pathway. Exp Cell Res. 2016;349:310-319 pubmed publisher
    ..In contrast, Rab2 does not stimulate GAPDH-Akt membrane binding but instead recruits GAPDH-aPKC...
  16. Caillol N, Pasqualini E, Lloubes R, Lombardo D. Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. J Cell Biochem. 2000;79:628-47 pubmed
    ..In rat AR4-2J cells, Rab6 as well as Rab1A/B and Rab2, partitioned between the cytosol and microsomes...
  17. Takata A, Ionita Laza I, Gogos J, Xu B, Karayiorgou M. De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia. Neuron. 2016;89:940-7 pubmed publisher
    ..Among the genes identified, several are hit by multiple functional de novo mutations, with RAB2A and SETD1A showing the highest statistical significance in ASD and SCZ, respectively...
  18. Goldenring J, Soroka C, Shen K, Tang L, Rodriguez W, Vaughan H, et al. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am J Physiol. 1994;267:G187-94 pubmed
    ..We have previously reported the presence of rab2 on parietal cell tubulovesicles (L. H. Tang, S. A. Stoch, I. M. Modlin, and J. R. Goldenring. Biochem. J...
  19. Li J, Liu B, Chen C, Cui Y, Shang L, Zhang Y, et al. RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory. Hum Brain Mapp. 2015;36:4372-82 pubmed publisher
    ..A recent genome-wide association and expression-SNP study indicated that the RAB2A gene was associated with the density of prefrontal calbindin-positive neurons, suggesting this gene may have a ..
  20. Khosravi Far R, Lutz R, Cox A, Conroy L, Bourne J, Sinensky M, et al. Isoprenoid modification of rab proteins terminating in CC or CXC motifs. Proc Natl Acad Sci U S A. 1991;88:6264-8 pubmed
    ..Therefore, rab proteins may be modified by a prenyltransferase(s) distinct from the prenyltransferases that modify carboxyl-terminal CAAX proteins. ..
  21. Li Y, Mi Z, Feng Y, McTiernan C, Zhou R, Robbins P, et al. Differential effects of overexpression of two forms of ephrin-A5 on neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2001;281:H2738-46 pubmed
    ..beta significantly upregulated the transcription of brain natriuretic peptide and downregulated ras-related protein RAB2, protein kinase C inhibitor protein-1, clusterin, and insulin-like growth factor-binding protein...
  22. Vielh E, Touchot N, Zahraoui A, Tavitian A. Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein. Nucleic Acids Res. 1989;17:1770 pubmed
  23. Dey K, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, et al. S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer Gene Ther. 2016;23:382-391 pubmed publisher
    ..the role of the S100A7 calcium-binding protein in oral squamous cell carcinoma as an activator of the p38/MAPK and RAB2A signaling pathway...
  24. Dey K, Pal I, Bharti R, Dey G, Kumar B, Rajput S, et al. Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach. Tumour Biol. 2015;36:9829-37 pubmed publisher
    ..signature proteins which have not been reported earlier in OSCC including ras-related protein Rab-2A isoform, RAB2A (4.6-fold), and peroxiredoxin-1, PRDX1 (2.2-fold)...
  25. Yin J, Huang Y, Guo P, Hu S, Yoshina S, Xuan N, et al. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. J Cell Biol. 2017;216:1775-1794 pubmed publisher
    ..elegans Rab2 GOP-1 transiently associates with cell corpse-containing phagosomes, and loss of its function abrogates ..
  26. Matsunaga K, Taoka M, Isobe T, Izumi T. Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. J Cell Sci. 2017;130:541-550 pubmed publisher
    ..Rab27a regulates the late steps in this process, such as granule recruitment to the fusion site, whereas Rab2a functions in the early steps, such as granule biogenesis and maturation...
  27. Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, et al. RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO Rep. 2016;17:1061-80 pubmed publisher
    ..Through a functional siRNA screening of human RAB GTPases, we found that RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness ..
  28. Janoueix Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem. 1995;270:14801-8 pubmed
    ..beta is functional; we show that recombinant mouse GDI beta is able to remove several Rab proteins, including Rab1, Rab2, Rab4, and Rab6, from membranes...
  29. de Leeuw H, Koster P, Calafat J, Janssen H, van Zonneveld A, Van Mourik J, et al. Small GTP-binding proteins in human endothelial cells. Br J Haematol. 1998;103:15-9 pubmed
    ..Two sequences corresponded to novel isoforms of Rab2 and Rab9. In addition, human analogues of Rab4b, Rab7, Rab9, Rab14 and Rab15 were identified...
  30. Herrou J, Crosson S. Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector. Biochemistry. 2013;52:9020-8 pubmed publisher
    ..The B. abortus RicA protein binds the host-expressed guanosine nucleotide-binding protein, Rab2, and modulates B. abortus infection biology. We have solved the first X-ray crystal structure of RicA to 2...
  31. Shisheva A, Chinni S, DeMarco C. General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. Biochemistry. 1999;38:11711-21 pubmed
    ..several Rab family members, divergent in structure, localized and operating on different membranes, including Rab2, Rab4, Rab5, Rab8, Rab9, and Rab11...
  32. de Barsy M, Jamet A, Filopon D, Nicolas C, Laloux G, Rual J, et al. Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cell Microbiol. 2011;13:1044-58 pubmed publisher
    ..proteins. We identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA...
  33. Kim S, Webster M. Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol Psychiatry. 2011;16:452-61 pubmed publisher
    ..Further eSNP analyses indicated that two novel candidate genes, RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal ..
  34. Eathiraj S, Pan X, Ritacco C, Lambright D. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005;436:415-9 pubmed
  35. Dong C, Wu G. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. Cell Signal. 2007;19:2388-99 pubmed
    Three Rab GTPases, Rab1, Rab2 and Rab6, are involved in protein transport between the endoplasmic reticulum (ER) and the Golgi...
  36. Short B, Preisinger C, Korner R, Kopajtich R, Byron O, Barr F. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. J Cell Biol. 2001;155:877-83 pubmed
    ..a novel coiled-coil protein golgin-45 interacts with the medial-Golgi matrix protein GRASP55 and the GTP form of rab2 but not other Golgi rab proteins...
  37. Zahraoui A, Touchot N, Chardin P, Tavitian A. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. J Biol Chem. 1989;264:12394-401 pubmed
    Seven cDNA clones corresponding to the rab1, rab2, rab3A, rab3B, rab4, rab5, and rab6 genes were isolated from a human pheochromocytoma cDNA library...
  38. Chou C, Hwang G, Hageman D, Han L, Agrawal P, Pisitkun T, et al. Identification of UT-A1 and AQP2 interacting proteins in rat inner medullary collecting duct. Am J Physiol Cell Physiol. 2017;:ajpcell.00082.2017 pubmed publisher
    ..Among the proteins unique to the AQP2 list were several Rab proteins (Rab1a, Rab2a, Rab5b, Rab5c, Rab7a, Rab11a, Rab11b, Rab14, Rab17) involved in membrane trafficking...
  39. Lőrincz P, Tóth S, Benkő P, Lakatos Z, Boda A, Glatz G, et al. Rab2 promotes autophagic and endocytic lysosomal degradation. J Cell Biol. 2017;216:1937-1947 pubmed publisher
    ..We also demonstrate that RAB2A is required for autophagosome clearance in human breast cancer cells...
  40. Mallik B, Dwivedi M, Mushtaq Z, Kumari M, Verma P, Kumar V. Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila. Development. 2017;144:2032-2044 pubmed publisher
    ..Moreover, reducing PICK1 or Rab2 levels phenocopies ICA69 mutation...
  41. Ni X, Ma Y, Cheng H, Jiang M, Guo L, Ji C, et al. Molecular cloning and characterization of a novel human Rab ( Rab2B) gene. J Hum Genet. 2002;47:548-51 pubmed
    ..The small GTPase Rab2 is a resident of pre-Golgi intermediates and is required for protein transport from the endoplasmic reticulum to ..
  42. Tisdale E. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J Biol Chem. 2003;278:52524-30 pubmed
    ..The small GTPase Rab2 selectively recruits the kinase to vesicular tubular clusters (VTCs) where PKCiota/lambda phosphorylates ..
  43. Tisdale E, Kelly C, Artalejo C. Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. J Biol Chem. 2004;279:54046-52 pubmed
    b>Rab2 requires atypical protein kinase C iota/lambda (aPKC iota/lambda) to promote vesicle formation from vesicular tubular clusters (VTCs)...
  44. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
    ..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking. ..
  45. Haas A, Yoshimura S, Stephens D, Preisinger C, Fuchs E, Barr F. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007;120:2997-3010 pubmed
  46. Luo M, Gong C, Chen C, Hu H, Huang P, Zheng M, et al. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015;11:111-24 pubmed publisher
    ..b>Rab2A is a small GTPase critical for vesicle trafficking...
  47. Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol. 2008;87:197-209 pubmed publisher
    ..Here we show that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex...
  48. Tisdale E, Balch W. Rab2 is essential for the maturation of pre-Golgi intermediates. J Biol Chem. 1996;271:29372-9 pubmed
    The small GTPase Rab2 is a resident of pre-Golgi intermediates and required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex (Tisdale, E. J., Bourne, J. R., Khosravi-Far, R. , Der, C. J., and Balch, W. E...
  49. Lardong J, Driller J, Depner H, Weise C, Petzoldt A, Wahl M, et al. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun. 2015;71:34-40 pubmed publisher
    ..This study focuses on Rab2 and Rab3 from Drosophila melanogaster...
  50. Yoshida H, Miyachi M, Ouchi K, Kuwahara Y, Tsuchiya K, Iehara T, et al. Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma. Genes Chromosomes Cancer. 2014;53:606-11 pubmed publisher
    ..Sequence analysis revealed two novel fusion genes, COL3A1-PLAG1 in three cases and RAB2A-PLAG1 in one case, respectively...
  51. Csizmadia T, Lorincz P, Hegedus K, Széplaki S, Low P, Juhasz G. Molecular mechanisms of developmentally programmed crinophagy in Drosophila. J Cell Biol. 2018;217:361-374 pubmed publisher
    ..We find that the tethering complex HOPS (homotypic fusion and protein sorting); the small GTPases Rab2, Rab7, and its effector, PLEKHM1; and a SNAP receptor complex consisting of Syntaxin 13, Snap29, and Vamp7 are all ..
  52. Tachibana K, Umezawa A, Kato S, Takano T. Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily. Nucleic Acids Res. 1988;16:10368 pubmed