RAB27B

Summary

Gene Symbol: RAB27B
Description: RAB27B, member RAS oncogene family
Alias: C25KG, ras-related protein Rab-27B
Species: human
Products:     RAB27B

Top Publications

  1. Ostenfeld M, Jeppesen D, Laurberg J, Boysen A, Bramsen J, Primdal Bengtson B, et al. Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties. Cancer Res. 2014;74:5758-71 pubmed publisher
    ..Silencing of the exocytotic RAB family members RAB27A or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion...
  2. Hendrix A, Sormunen R, Westbroek W, Lambein K, Denys H, Sys G, et al. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer. Int J Cancer. 2013;133:843-54 pubmed publisher
    The secretory Rab27B small GTPase promotes invasive growth and metastasis in estrogen receptor (ER) ?-positive breast cancer cells by orchestrating the peripheral targeting of vesicles secreting proinvasive growth regulators...
  3. Zhang J, Huang X, Cai M, Tong Z, Chen J, Qian D, et al. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis. J Transl Med. 2012;10:242 pubmed publisher
    The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significance of Rab27B in BC patients...
  4. Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van Den Broecke R, et al. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst. 2010;102:866-80 pubmed publisher
    BACKGROUND Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown...
  5. Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12:19-30; sup pp 1-13 pubmed publisher
    ..Among these, Rab27a and Rab27b were found to function in MVE docking at the plasma membrane...
  6. Nagata K, Itoh H, Katada T, Takenaka K, Ui M, Kaziro Y, et al. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. J Biol Chem. 1989;264:17000-5 pubmed
    We have purified, characterized, and identified two GTP-binding proteins with Mr of 25,000 (c25KG) and 21,000 (c21KG) from the cytosol fraction of human platelets...
  7. Chen D, Guo J, Miki T, Tachibana M, Gahl W. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochem Mol Med. 1997;60:27-37 pubmed
    ..We isolated the complete cDNAs of two rab isoforms, rab27a and rab27b, from human melanoma cells and melanocytes, Rab27a is the human homolog of a rat megakaryocyte rab called ram p25...
  8. Barral D, Ramalho J, Anders R, Hume A, Knapton H, Tolmachova T, et al. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest. 2002;110:247-57 pubmed
    ..Here we present evidence that Rab27a function can be compensated by a closely related protein, Rab27b. Rab27b is expressed in platelets and other tissues but not in melanocytes or CTLs...
  9. Hendrix A, Braems G, Bracke M, Seabra M, Gahl W, De Wever O, et al. The secretory small GTPase Rab27B as a marker for breast cancer progression. Oncotarget. 2010;1:304-8 pubmed
    ..We recently discovered that the secretory small GTPase Rab27B, a regulator of vesicle exocytosis, delivers proinvasive signals for increased invasiveness, tumor size, and ..

More Information

Publications65

  1. Westbroek W, Lambert J, De Schepper S, Kleta R, Van Den Bossche K, Seabra M, et al. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res. 2004;17:498-505 pubmed
    ..of functional Rab27a in melanocytes of this Griscelli patient is partially compensated by the up-regulation of Rab27b, a homologue of Rab27a...
  2. Zhang J, Zhang K, Qi L, Hu Q, Shen Z, Liu B, et al. DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes. Biochim Biophys Acta Mol Cell Res. 2019;1866:916-929 pubmed publisher
    ..Consistent with these results, Rab27a and Rab27b, two Rabs involved in endosome motility and exosome biogenesis, were found to act downstream of FAM45A pathway...
  3. Li W, Hu Y, Jiang T, Han Y, Han G, Chen J, et al. Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64. APMIS. 2014;122:1080-7 pubmed publisher
    ..found that EPI64 participated in the exosome secretion of A549 cells by acting as a specific GAP for Rab27A, not Rab27B. Overexpression of EPI64 enhanced exosome secretion...
  4. Rezaie J, Nejati V, Khaksar M, Oryan A, Aghamohamadzadeh N, Shariatzadeh M, et al. Diabetic sera disrupted the normal exosome signaling pathway in human mesenchymal stem cells in vitro. Cell Tissue Res. 2018;374:555-565 pubmed publisher
    ..The expression of key genes such as CD63, Alix, Rab27a, Rab27b, and Rab8b was monitored by real-time PCR...
  5. Yang J, Zhang Z, Zhang Y, Ni X, Zhang G, Cui X, et al. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. Gastroenterology. 2019;156:722-734.e6 pubmed publisher
    ..heat shock protein (HSP) 70 and HSP90, which are associated with EVs, by decreasing CREB-regulated expression of RAB27B. ZIP4 promotes growth of orthotopic pancreatic tumors in mice and loss of muscle mass by activating CREB-regulated ..
  6. Johnson J, Brzezinska A, Tolmachova T, Munafo D, Ellis B, Seabra M, et al. Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic. 2010;11:533-47 pubmed publisher
    ..Using mouse neutrophils deficient in Rab27a (Rab27a(ash/ash)), Rab27b [Rab27b knockout (KO)] or both [Rab27a/b double KO (DoKo)], we investigated the role of the Rab27 isoforms in ..
  7. Figueiredo A, Wasmeier C, Tarafder A, Ramalho J, Baron R, Seabra M. Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem. 2008;283:23209-16 pubmed publisher
    ..Recombinant Rab3GEP exhibits guanine nucleotide exchange activity against Rab27a and Rab27b in vitro, in addition to its previously documented activity against Rab3...
  8. McGrath J, Stone K, Begum R, Simpson M, Dopping Hepenstal P, Liu L, et al. Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility. Am J Hum Genet. 2012;91:1115-21 pubmed publisher
    The Rab GTPase Rab27B and one of its effector proteins, Slac2-b (also known as EXPH5, exophilin-5), have putative roles in intracellular vesicle trafficking but their relevance to human disease is not known...
  9. Jacobs D, Weigert R, Grode K, Donaldson J, Cheney R. Myosin Vc is a molecular motor that functions in secretory granule trafficking. Mol Biol Cell. 2009;20:4471-88 pubmed publisher
    ..Myo5c puncta colocalize with secretory granule markers such as chromogranin A and Rab27b, whereas Myo5c tubules are labeled by Rab8a...
  10. Li Z, Scott M, Brzoska T, Sundd P, Li Y, Billiar T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res. 2018;5:24 pubmed publisher
    ..The secreted interleukin (IL)-25 from LEPCs downregulates Rab27a and Rab27b expression in Mϕ, resulting in suppressed exosome release and thereby attenuating exosome-induced TNF-α ..
  11. Chin A, Yan W, Cao M, Liu X, Wang S. Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia. 2018;23:165-176 pubmed publisher
    ..from the apical versus basolateral compartments, we found that impaired secretion of EVs by knockdown of RAB27A or RAB27B suppressed the establishment of mammary epithelial polarity, and that addition of apical but not basolateral EVs ..
  12. Singh R, Furze R, Birrell M, Rankin S, Hume A, Seabra M. A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol. 2014;15:39 pubmed publisher
    ..b>Rab27b has been implicated in primary granule exocytosis but its role in neutrophil migration has not been investigated...
  13. Bolasco G, Tracey White D, Tolmachova T, Thorley A, Tetley T, Seabra M, et al. Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol. 2011;300:C466-76 pubmed publisher
    ..Previous studies indicated that Rab27a and Rab27b are expressed in the murine lung suggesting that they regulate secretory processes in the lung...
  14. Walker B, Schmid E, Russo A, Schmidt E, Burk O, Münzer P, et al. Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion. J Thromb Haemost. 2015;13:1325-34 pubmed publisher
    ..Transcript levels and protein abundance of dense granule biogenesis regulating GTPase Rab27b were significantly reduced in sgk1(-/-) platelets without affecting Rab27b mRNA stability...
  15. Hou Y, Ernst S, Stuenkel E, Lentz S, Williams J. Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion. PLoS ONE. 2015;10:e0125596 pubmed publisher
    ..Compared to wild-type, expression of Rab27B was slightly increased in ashen mouse acini, while Rab3D and digestive enzymes (amylase, lipase, chymotrypsin and ..
  16. Sekine Y, Lin Moore A, Chenette D, Wang X, Jiang Z, CAFFERTY W, et al. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Rep. 2018;23:415-428 pubmed publisher
    ..elegans validates a cell-autonomous restriction of regeneration by Rab27. Mice lacking Rab27b show enhanced retinal ganglion cell axon regeneration after optic nerve crush and greater motor function and ..
  17. Davila J, Laws M, Kannan A, Li Q, Taylor R, Bagchi M, et al. Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet. 2015;11:e1005458 pubmed publisher
    ..of Rac1, we performed gene expression profiling which revealed that Rac1 signaling regulates the expression of Rab27b, another GTPase that plays a key role in targeting vesicular trafficking...
  18. Felix J, Bradfield J, Monnereau C, van der Valk R, Stergiakouli E, Chesi A, et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet. 2016;25:389-403 pubmed publisher
    ..We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0...
  19. Meng Z, Edman M, Hsueh P, Chen C, Klinngam W, Tolmachova T, et al. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016;310:C942-54 pubmed publisher
    ..Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC...
  20. Xu A, Lu J, Ran Z, Zheng Q. Exosome in intestinal mucosal immunity. J Gastroenterol Hepatol. 2016;31:1694-1699 pubmed publisher
    ..RAB27A and RAB27B are two small GTPases involved in exosome secretion...
  21. Broner E, Trope C, Reich R, Davidson B. TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma. Hum Pathol. 2017;60:180-187 pubmed publisher
    ..The mRNA expression levels of ARF6, nSMase2, TSAP6, Rab27a and Rab27b by quantitative real-time reverse-transcription polymerase chain reaction were analyzed in 103 HGSC effusions and ..
  22. Higashio H, Satoh Y, Saino T. Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37. Sci Rep. 2016;6:22539 pubmed publisher
    Mast cell degranulation is regulated by the small guanosine triphosphatases (GTPases) Rab27a and Rab27b, which have distinct and opposing roles: Rab27b acts as a positive regulator through its effector protein Munc13-4, a non-neuronal ..
  23. Peng D, Wang H, Li L, Ma X, Chen Y, Zhou H, et al. miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. Leukemia. 2018;32:1180-1188 pubmed publisher
    ..increase its intracellular level by inhibiting exosome-mediated transfer via a positive feedback loop through RAB27B, a molecule that promotes exosome shedding...
  24. Shen Y, Gu Y, Su W, Zhong J, Jin Z, Gu X, et al. Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes. Neurosci Bull. 2016;32:331-40 pubmed publisher
    ..Here, we demonstrated that a small GTPase, Rab27b, is involved in PLP trafficking in oligodendrocytes...
  25. Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera Salcedo I, et al. Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. J Cell Biol. 2016;215:203-216 pubmed
    ..We identified Slp3 as the critical effector linking kinesin-1 to Rab27b-associated SGs...
  26. Chen Y, Fang Y, Cheng Y, Lin C, Hsu L, Wang S, et al. Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells. Sci Rep. 2017;7:5676 pubmed publisher
    ..Furthermore, knockdown of RAB8A and RAB27A, but not RAB27B, reduced IFN-γ-triggered ANXA2 secretion...
  27. Ramalho J, Tolmachova T, Hume A, McGuigan A, Gregory Evans C, Huxley C, et al. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet. 2001;2:2 pubmed
    Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in Griscelli Disease, a disease combining partial albinism with severe immunodeficiency...
  28. Zhao S, Torii S, Yokota Hashimoto H, Takeuchi T, Izumi T. Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology. 2002;143:1817-24 pubmed
    ..In the present study we characterized another isoform, Rab27b, to further investigate the function of the Rab27 subfamily...
  29. Zhao H, Wang Q, Wang X, Zhu H, Zhang S, Wang W, et al. Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer. Pancreas. 2016;45:204-10 pubmed publisher
    b>RAB27B is a member of the Rab family GTPases involved in vesicle trafficking, and p53 has recently been implicated in regulating the exosome secretion pathway...
  30. Shirakawa R, Higashi T, Tabuchi A, Yoshioka A, Nishioka H, Fukuda M, et al. Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem. 2004;279:10730-7 pubmed
    ..show that incubation of permeabilized platelets with unprenylated active mutant Rab27A-Q78L, wild type Rab27A, and Rab27B inhibited the secretion, whereas inactive mutant Rab27A-T23N and other GTPases had no effects...
  31. Miao Y, Bist P, Wu J, Zhao Q, Li Q, Wan Y, et al. Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. Cell Host Microbe. 2017;22:330-342.e4 pubmed publisher
    ..RAB11a and RAB27b and their trafficking circuitry are simultaneously involved in UPEC expulsion...
  32. Gallo L, Dalghi M, Clayton D, Ruiz W, Khandelwal P, Apodaca G. RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. Am J Physiol Cell Physiol. 2017;:ajpcell.00218.2017 pubmed publisher
    ..We previously showed that DFV exocytosis depends in part on a RAB11A-RAB8A-MYO5B network, but RAB27B is also reported to be associated with DFVs, and knockout mice lacking RAB27B have fewer DFVs...
  33. Dong W, Cui J, Yang J, Li W, Wang S, Wang X, et al. Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer. Discov Med. 2015;20:357-67 pubmed
    ..Thus, this research was designed to explore the clinical and prognostic significance of Rab27A and Rab27B in colorectal cancer (CRC) patients...
  34. Kondo H, Shirakawa R, Higashi T, Kawato M, Fukuda M, Kita T, et al. Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets. J Biol Chem. 2006;281:28657-65 pubmed
    ..Taken together, Rab27 is maintained in the active status in unstimulated platelets, which could function to keep dense granules in a preparative status for secretion. ..
  35. Jaé N, McEwan D, Manavski Y, Boon R, Dimmeler S. Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles. FEBS Lett. 2015;589:3182-8 pubmed publisher
    ..Here we identified a vesicular export mechanism for miR-143, induced by the shear stress responsive transcription factor KLF2, and demonstrate its dependency on Rab7a/Rab27b in endothelial cells.
  36. Suda J, Zhu L, Okamoto C, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology. 2011;140:868-78 pubmed publisher
    ..Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation...
  37. Masliah Planchon J, Bellucci S, Darnige L, Callebert J, Fischer A, Tapon Bretaudiere J. Absence of mutation in the RAB27B gene in patients with platelet delta-storage pool deficiency. Eur J Haematol. 2011;86:350-1 pubmed publisher
  38. Tiwari S, Italiano J, Barral D, Mules E, Novak E, Swank R, et al. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003;102:3970-9 pubmed
    ..number of Rab proteins with defective membrane association in gm/gm megakaryocytes prominently includes Rab27a and Rab27b. Normal expression of Rab27b is especially increased with terminal megakaryocyte differentiation and dependent on ..
  39. Wang W, Ni Q, Wang H, Zhang S, Zhu H. Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors. Dis Markers. 2014;2014:942181 pubmed publisher
    Rab proteins of the endocytosis and exocytosis pathways both play critical roles in cancer progression, and Rab27B has a significant relationship with several types of human cancer...
  40. Hendrix A, De Wever O. Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment. Int J Mol Sci. 2013;14:9883-92 pubmed publisher
    ..Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy. ..
  41. Tanaka C, Kaji H, He J, Hazama R, Yokoyama K, Kinoshita E, et al. Rab27b regulates c-kit expression by controlling the secretion of stem cell factor. Biochem Biophys Res Commun. 2012;419:368-73 pubmed publisher
    b>Rab27b, a subfamily of Rab27 small GTPases, was originally identified in platelets. However, the role of Rab27b in megakaryocytic lineage cells remains unknown...
  42. Yang X, Ye X, Sun L, Gao F, Li Y, Ji X, et al. Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling. Oncotarget. 2017;8:61118-61132 pubmed publisher
    Previous study revealed that elevated expression of RAB27B in tissues is correlated with hepatocellular carcinoma (HCC) progression; however, the mechanisms involved in promoting HCC development are still unclear...
  43. Nagata K, Hattori T, Hachiya T, Takahashi T, Nozawa Y. Purification and characterization of a low M(r) GTP-binding protein, c25KG, from human platelet membranes. Biochim Biophys Acta. 1992;1160:193-8 pubmed
    ..a sodium cholate extract of human platelet membranes by using an antibody raised against a synthetic peptide of c25KG, which was previously purified from human platelet cytosol (Nagata, N., et al. (1989) J. Biol. Chem...
  44. Song J, Bishop B, Li G, Grady R, Stapleton A, Abraham S. TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci U S A. 2009;106:14966-71 pubmed publisher
    ..Also, we reveal that caveolin-1, Rab27b, PKA, and MyRIP are components of the exocytic compartment, and that they form a complex involved in the ..
  45. Strom M, Hume A, Tarafder A, Barkagianni E, Seabra M. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem. 2002;277:25423-30 pubmed
    ..Thus, melanophilin can associate simultaneously with activated Rab27a and myosin Va via distinct regions, and serve as a linker between these proteins. ..
  46. Mikurova A, Novikova S, Skvortsov V, Alekseychuk N, Rybina A, Miroshnichenko Y. [The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins]. Biomed Khim. 2017;63:397-404 pubmed publisher
    The aim of this study was to evaluate sequence coverage of five model proteins (CYB5A, SMAD4, RAB27B, FECH, and CXXC1) by means of shotgun proteomic data analysis employing different methods of data treatment including database-dependent ..
  47. Alexander M, Ramstead A, Bauer K, Lee S, Runtsch M, Wallace J, et al. Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli. J Immunol. 2017;199:3559-3570 pubmed publisher
    ..In this article, we demonstrate that Rab27a and Rab27b double-knockout (Rab27DKO) mice that are deficient in exosome secretion have a chronic, low-grade inflammatory ..
  48. Wankel B, Ouyang J, Guo X, Hadjiolova K, Miller J, Liao Y, et al. Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells. Mol Biol Cell. 2016;27:1621-34 pubmed publisher
    ..Immunomicroscopy of normal and mutant mouse urothelia show that the UP-delivering FVs contained Rab8/11 and Rab27b/Slac2-a, which mediate apical transport along actin filaments...
  49. Gomi H, Osawa H, Uno R, Yasui T, Hosaka M, Torii S, et al. Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties. J Histochem Cytochem. 2017;65:637-653 pubmed publisher
    ..Similarly, Rab proteins (Rab3d, Rab11a, Rab11b, Rab27a, and Rab27b) and soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) proteins VAMP4, VAMP8, ..
  50. Worst T, Meyer Y, Gottschalt M, Weis C, von Hardenberg J, Frank C, et al. RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells. Int J Oncol. 2017;50:920-932 pubmed publisher
    ..in vesicular trafficking and secretion in an existing microarray dataset revealed low expression of RAB27A, RAB27B and VPS36 to be predictive for reduced BCR-free survival in patients with localized PCa (p=0.033, 0.025 and 0.005)...
  51. Hayasaka S, Terada Y, Suzuki K, Murakawa H, Tachibana I, Sankai T, et al. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. Asian J Androl. 2008;10:561-8 pubmed publisher
    ..motor myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein (MyRIP), and vesicle receptor Rab27b on an F-actin track were present during human and monkey spermiogenesis involving intramanchette transport (IMT)...
  52. Hou Y, Ernst S, Lentz S, Williams J. Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. Biochem Biophys Res Commun. 2016;471:610-5 pubmed publisher
    Small G protein Rab27B is expressed in various secretory cell types and plays a role in mediating secretion...
  53. Zhang Y, Sun L, Sun H, Liu X, Luo X, Li C, et al. Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene. Cell Mol Biol (Noisy-le-grand). 2017;63:80-86 pubmed publisher
    ..Bioinformatics was used to predict the target gene of miR-133b. Silencing of Rab27B gene was achieved by transfection with its small-interfering RNA...
  54. Sun T, Li Y, Li T, Ma H, Guo Y, Jiang X, et al. JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1. Cell Mol Life Sci. 2017;74:4027-4044 pubmed publisher
    ..axonal delivery is mediated by kinesin-1, which associates with TrkB via the adaptor protein JIP3 or the Slp1/Rab27B/CRMP-2 protein complex. However, little is known about the activation mechanisms of TrkB-loaded kinesin-1...
  55. Wang H, Wang Y, Bao Z, Zhang C, Liu Y, Cai J, et al. Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion. Oncol Rep. 2015;34:1503-9 pubmed publisher
    ..We found that Rab27b was hypomethylated in high-grade glioma (anaplastic gliomas and glioblastomas) compared with low-grade glioma (..
  56. Pu Y, Zhao F, Cai W, Meng X, Li Y, Cai S. MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively. Clin Exp Metastasis. 2016;33:359-72 pubmed publisher
    ..bioinformatics prediction along with biochemical assay results clearly suggested that the secretory small GTPase Rab27B and serine racemase (SRR) were direct targets of miR-193a-3p and miR-193a-5p, respectively...