Gene Symbol: RAB25
Description: RAB25, member RAS oncogene family
Alias: CATX-8, RAB11C, ras-related protein Rab-25
Species: human
Products:     RAB25

Top Publications

  1. Kessler D, Gruen G, Heider D, Morgner J, Reis H, Schmid K, et al. The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration. Cell Physiol Biochem. 2012;29:647-56 pubmed publisher
    The closely related GTPases Rab11 and Rab25 promote cell migration by regulating vesicular transport and recycling of surface receptors. Rab25 carries a constitutively activating mutation in its GTPase domain...
  2. Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, et al. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013;19:1375-88 pubmed publisher
    ..b>Rab25 expression level was analyzed in HNSCC tissue microarray...
  3. Nam K, Lee H, Smith J, Lapierre L, Kamath V, Chen X, et al. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest. 2010;120:840-9 pubmed publisher
    ..Here we have demonstrated a tumor suppressor function for Rab25 in intestinal neoplasia in both mice and humans...
  4. Cheng J, Volk L, Janaki D, Vyakaranam S, Ran S, Rao K. Tumor suppressor function of Rab25 in triple-negative breast cancer. Int J Cancer. 2010;126:2799-812 pubmed publisher
    ..We have recently shown that Rab25 is lost in a large fraction of breast cancer samples, particularly those derived from hormonally insensitive ..
  5. Zhao M, Yin Y, Guo F, Yang Y, Shen F, Chen Q. Increased Rab25 expression is not correlated with peritoneal metastasis of ovarian cancers. Cancer Invest. 2012;30:683-7 pubmed publisher
    Ovarian cancer is the leading cause of death in gynecological cancer. Studies suggested Rab25 is involved in the pathogenesis of ovarian cancers...
  6. Tong M, Chan K, Bao J, Wong K, Chen J, Kwan P, et al. Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res. 2012;72:6024-35 pubmed publisher
    ..The Rab25 gene implicated in endocytic recycling of integrins was the only gene in this group significantly downregulated, ..
  7. Cheng K, Agarwal R, Mitra S, Lee J, Carey M, Gray J, et al. Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med. 2012;4:125-41 pubmed publisher
    ..We demonstrate that Rab25, a small GTPase involved in endosomal recycling, that is genomically amplified in multiple tumour lineages, is a ..
  8. Goldenring J, Shen K, Vaughan H, Modlin I. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem. 1993;268:18419-22 pubmed
    ..Six out of 53 clones demonstrated a novel Rab sequence, now designated Rab25. The complete sequence was obtained using 3'-RACE and revealed a deduced amino acid sequence having 63% identity ..
  9. Yin Y, Shen F, Pei H, Ding Y, Zhao H, Zhao M, et al. Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis. Tumour Biol. 2012;33:1581-7 pubmed publisher
    Breast cancer is the most common cancer in women worldwide. Studies have suggested that Ras-related protein 25 (Rab25), a member of Rab small GTPase family, is involved in the pathogenesis of breast cancer...

More Information


  1. Caswell P, Spence H, Parsons M, White D, Clark K, Cheng K, et al. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell. 2007;13:496-510 pubmed
    Here, we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis...
  2. Fan Y, Xin X, Chen B, Ma X. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. Pathology. 2006;38:561-7 pubmed
    Ovarian cancer is the leading cause of cancer death among gynaecological malignancies. Elevated expression of Rab25 has been seen in this malignancy...
  3. Cheng K, Lahad J, Kuo W, Lapuk A, Yamada K, Auersperg N, et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004;10:1251-6 pubmed
    High-density array comparative genomic hybridization (CGH) showed amplification of chromosome 1q22 centered on the RAB25 small GTPase, which is implicated in apical vesicle trafficking, in approximately half of ovarian and breast cancers...
  4. Krishnan M, Lapierre L, Knowles B, Goldenring J. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell. 2013;24:818-31 pubmed publisher
    b>Rab25 is a tumor suppressor for colon cancer in humans and mice...
  5. Zhang J, Wei J, Lu J, Tong Z, Liao B, Yu B, et al. Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3?/Snail signaling. Carcinogenesis. 2013;34:2401-8 pubmed publisher
    b>Rab25, an epithelial-specific member of the Rab family of small guanosine triphosphatases, is associated with several human cancers. The goal of this study was to determine its function in bladder cancer (BC)...
  6. Lapierre L, Kumar R, Hales C, Navarre J, Bhartur S, Burnette J, et al. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell. 2001;12:1843-57 pubmed
    ..terminal 60 kDa of the myosin Vb tail, interacted with all members of the Rab11 family (Rab11a, Rab11b, and Rab25)...
  7. Roland J, Kenworthy A, Peranen J, Caplan S, Goldenring J. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol Biol Cell. 2007;18:2828-37 pubmed
    ..Additionally, dynamic live cell imaging demonstrates distinct pathways for Rab11a and Rab8a vesicle trafficking. These findings indicate that Rab8a and Rab11a define different recycling pathways that both use Myosin Vb. ..
  8. Qiu S, Xu H, Lin Z, Liu F, Tan F. The blockade of lipophagy pathway is necessary for docosahexaenoic acid to regulate lipid droplet turnover in hepatic stellate cells. Biomed Pharmacother. 2019;109:1841-1850 pubmed publisher
    ..It has been reported that lipophagy activation contributed to LD loss by upregulating RAB25 expression...
  9. Jeong B, Cho K, Jeong K, Park Y, Kim J, Rha S, et al. Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin. Exp Mol Med. 2018;50:e435 pubmed publisher
    The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage...
  10. Leth Larsen R, Terp M, Christensen A, Elias D, Kühlwein T, Jensen O, et al. Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis. Mol Med. 2012;18:1109-21 pubmed publisher
    ..of breast cancer cells with tumor-initiating features, such as lipolysis-stimulated lipoprotein receptor (LSR), RAB25, S100A14 and mucin 1 (MUC1), as well as a novel 31-gene signature capable of predicting distant metastasis in ..
  11. Lill C, Roehr J, McQueen M, Kavvoura F, Bagade S, Schjeide B, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012;8:e1002548 pubmed publisher
    ..with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (..
  12. Skrypek N, Bruneel K, Vandewalle C, De Smedt E, Soen B, Loret N, et al. ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition. Epigenetics Chromatin. 2018;11:70 pubmed publisher
    ..we aimed to characterize the epigenetic effect of ZEB2 repressive function on the regulation of a small Rab GTPase RAB25. Using cellular models with conditional ZEB2 expression, we show a clear transcriptional repression of RAB25 and ..
  13. Aue A, Hinze C, Walentin K, Ruffert J, Yurtdas Y, Werth M, et al. A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion. J Am Soc Nephrol. 2015;26:2704-15 pubmed publisher
    ..the ovo-like 2 zinc finger transcription factor, as well as E-cadherin, claudin 4 (Cldn4), and the small GTPase Rab25. Ovol2 induction alone was sufficient to bypass the requirement of Grhl2 for E-cadherin, Cldn4, and Rab25 ..
  14. Bhat A, Pope J, Smith J, Ahmad R, Chen X, Washington M, et al. Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Oncogene. 2015;34:4570-80 pubmed publisher
    ..Furthermore, Rab25, a colon cancer suppressor and regulator of the polarized cell trafficking constituted one of the highly ..
  15. Barrile R, Kasendra M, Rossi Paccani S, Merola M, Pizza M, Baldari C, et al. Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier. Cell Microbiol. 2015;17:1365-75 pubmed publisher
    ..compartments was evaluated through the concomitant staining of bacteria and markers specific for Rab11, Rab22a, Rab25 and Rab3 followed by confocal microscopy imaging...
  16. Park M, Baek I, Kim H, Woo D, Park Y, Shim S. CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25. Biochem Biophys Res Commun. 2015;461:456-62 pubmed publisher
    ..Moreover, we identified the small GTPase RAB25 as a downstream effector molecule of CCN3 using transcriptomic analysis with CCN3 overexpressed in cortical tissue...
  17. Barile M, Pisitkun T, Yu M, Chou C, Verbalis M, Shen R, et al. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Mol Cell Proteomics. 2005;4:1095-106 pubmed
    ..of Rab GTPases 4, 5, 18, and 21 (associated with early endosomes); Rab7 (late endosomes); and Rab11 and Rab25 (recycling endosomes) indicate that a substantial fraction of intracellular AQP2 is present in endosomal ..
  18. Mitra S, Molina J, Mills G, Dennison J. Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance. Methods Mol Biol. 2015;1298:195-205 pubmed publisher
    b>Rab25, by altering trafficking of critical cellular resources, influences cell metabolism and survival during stress conditions...
  19. Zhang J, Chang D, Yang Y, Zhang X, Tao W, Jiang L, et al. Systematic investigation on the intracellular trafficking network of polymeric nanoparticles. Nanoscale. 2017;9:3269-3282 pubmed publisher
    ..Moreover, the slow (Rab11 and Rab35 positive), fast (Rab4 positive) and apical (Rab20 and Rab25 positive) endocytic recycling endosome pathways could transport the PLGA nanoparticles to lysosomes...
  20. Bannister J, Bulley S, Leo M, Kidd M, Jaggar J. Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells. Am J Physiol Cell Physiol. 2016;310:C885-93 pubmed publisher
    ..2 channels in cerebral artery myocytes. Western blotting indicated that Rab25, a GTPase previously associated with apical recycling endosomes, is expressed in cerebral artery myocytes...
  21. Tóth A, Siupka P, P Augustine T, Venø S, Thomsen L, Moos T, et al. The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro. Mol Neurobiol. 2018;55:8522-8537 pubmed publisher
    ..Cytosolic proteins involved in subcellular trafficking were investigated to mark transport routes, such as RAB25 for transcytosis...
  22. Hu C, Chen B, Zhou Y, Shan Y. High expression of Rab25 contributes to malignant phenotypes and biochemical recurrence in patients with prostate cancer after radical prostatectomy. Cancer Cell Int. 2017;17:45 pubmed publisher
    Ras-related protein 25 (Rab25) functions either as an oncogene or a tumor suppressor with a cancer type-dependent manner. We aimed to investigate clinical significance of Rab25 in prostate cancer (PCa)...
  23. Boulay P, Mitchell L, Turpin J, Huot Marchand J, Lavoie C, Sanguin Gendreau V, et al. Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression. Cancer Res. 2016;76:2662-74 pubmed publisher
    Rab coupling protein (FIP1C), an effector of the Rab11 GTPases, including Rab25, is amplified and overexpressed in 10% to 25% of primary breast cancers and correlates with poor clinical outcome...
  24. Sesar A, Cacheiro P, López López M, Camiña Tato M, Quintáns B, Monroy Jaramillo N, et al. Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico. J Neurol Sci. 2016;362:321-5 pubmed publisher
    ..SNPs from the GBA-SYT11-RAB25 region have been previously associated with PD, however the functionally relevant variants remain unknown...
  25. Gomez Roman N, McGregor F, Wheate N, Plumb J. Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model. J Ovarian Res. 2015;8:62 pubmed publisher
    ..p.) xenografts using the human ovarian cancer cell line A2780 stably expressing the small GTPase Rab25, which allows A2780 intraperitoneal growth; and luciferase, to allow tumour load measurement by non-invasive ..
  26. McGovern F, Sweeney T, Ryan M, Lott S, Campion F, Boland T. An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum. Br J Nutr. 2017;117:951-963 pubmed publisher
    ..concentration, ileal morphology and the gene expression of THRB and B2M in the ileum and ras-related protein (RAB) RAB25 and the mucin gene (MUC) MUC1 in the duodenum of the lamb postpartum...
  27. Gruber R, Rogerson C, Windpassinger C, Banushi B, Straatman Iwanowska A, Hanley J, et al. Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification. J Invest Dermatol. 2017;137:845-854 pubmed publisher
    ..mutations were found in VPS33B, encoding VPS33B, a Sec1/Munc18 family protein that interacts with Rab11a and Rab25 proteins and is involved in trafficking of the collagen-modifying enzyme LH3...
  28. Li Y, Jia Q, Zhang Q, Wan Y. Rab25 upregulation correlates with the proliferation, migration, and invasion of renal cell carcinoma. Biochem Biophys Res Commun. 2015;458:745-50 pubmed publisher
    ..Our results showed that high levels of Rab25 expression were significantly correlated with RCC invasion classification (P < 0...
  29. Mitra S, Montgomery J, Kolar M, Li G, Jeong K, Peng B, et al. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer. Nat Commun. 2017;8:660 pubmed publisher
    Recent evidence has established a role for the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and anti-oncogenic phenotypes in specific cellular contexts...
  30. Ray G, Lee J, Nwokeji K, Mills L, Goldenring J. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. Lab Invest. 1997;77:503-11 pubmed
    ..specimens from 4 patients and endoscopic biopsies from 60 patients were stained with antibodies against Rab11 and Rab25 as well as protein markers of the Golgi apparatus and p53 protein...
  31. Davidson B, Holth A, Hellesylt E, Tan T, Huang R, Tropé C, et al. The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. Hum Pathol. 2015;46:1-8 pubmed publisher
    ..Expression of E-cadherin, N-cadherin, P-cadherin, Zeb1, HMGA2, Rab25, CD24, NCAM (CD56), Sox11, and vimentin was assessed in 100 advanced-stage (International Federation of Gynecology ..
  32. Mitra S, Cheng K, Mills G. Rab25 in cancer: a brief update. Biochem Soc Trans. 2012;40:1404-8 pubmed publisher
    ..b>Rab25 is an epithelial-cell-specific member of the Rab GTPase superfamily, sharing close homology with Rab11a, the ..
  33. Clausen M, Melchers L, Mastik M, Slagter Menkema L, Groen H, Laan B, et al. RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis. Epigenetics. 2016;11:653-663 pubmed
    ..b>RAB25, a known tumor suppressor gene, was the highest-ranking gene in the discovery set...
  34. Ma Y, Yang B, Li J, Zhang T, Guo J, Chen L, et al. Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer. Genet Mol Res. 2015;14:13998-4008 pubmed publisher
    Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown...
  35. Nalls M, Plagnol V, Hernandez D, Sharma M, Sheerin U, Saad M, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 2011;377:641-9 pubmed publisher
    ..These data provide an insight into the genetics of Parkinson's disease and the molecular cause of the disease and could provide future targets for therapies. Wellcome Trust, National Institute on Aging, and US Department of Defense. ..
  36. Yu X, Bian X, Throop A, Song L, Moral L, Park J, et al. Exploration of panviral proteome: high-throughput cloning and functional implications in virus-host interactions. Theranostics. 2014;4:808-22 pubmed publisher
    ..These valuable plasmid resources will be available to the research community to enable continued viral functional studies. ..
  37. Hales C, Griner R, Hobdy Henderson K, Dorn M, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067-75 pubmed publisher
    ..proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as Rab11b and Rab25. Rab11-FIP2 also interacted with dominant negative Rab11a (Rab11aS25N) and the tail of myosin Vb...
  38. Lall P, Horgan C, Oda S, Franklin E, Sultana A, Hanscom S, et al. Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase. Biochim Biophys Acta. 2013;1834:2679-90 pubmed publisher
    ..Rab25, also known as Rab11c, which is epithelial-specific, has been heavily implicated in ovarian cancer development and independently appears ..
  39. Zhang Z, Zhao S, Yao Z, Wang L, Shao J, Chen A, et al. Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell. Redox Biol. 2017;11:322-334 pubmed publisher
    ..Besides, we found that HSC activation triggered Rab25 overexpression, and promoted the combination of Rab25 and PI3KCIII, which direct autophagy to recognize, wrap and ..
  40. Nikoshkov A, Broliden K, Attarha S, Sviatoha V, Hellström A, Mints M, et al. Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues. Int J Oncol. 2015;46:107-12 pubmed publisher
    ..and alternative splicing, we aimed to analyze the splicing patterns of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes, which are associated with different cancers, in normal cervical tissue, preinvasive cervical lesions and ..
  41. Gomez Roman N, Sahasrabudhe N, McGregor F, Chalmers A, Cassidy J, Plumb J. Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget. 2016;7:22650-64 pubmed publisher
    The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments...
  42. Gu Y, Zou Y, Lei D, Huang Y, Li W, Mo Z, et al. Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma. Sci Rep. 2017;7:14200 pubmed publisher
    ..The biomarker was validated in 19 ccRCCs and three public datasets. We found that both CYP4B1 and RAB25 are downregulated with promoter hypermethylation and CA9 is upregulated with promoter hypomethylation, and we ..
  43. Taglauer E, Artemiuk P, Hanscom S, Lindsay A, Wuebbolt D, Breathnach F, et al. Rab11 family expression in the human placenta: Localization at the maternal-fetal interface. PLoS ONE. 2017;12:e0184864 pubmed publisher
    ..The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo ..
  44. Kikuchi M, Yamashita K, Waraya M, Minatani N, Ushiku H, Kojo K, et al. Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. Oncotarget. 2016;7:1741-53 pubmed publisher
    ..CRL and MDAMB453 cells were identified as PB-sensitive, while MDAMB231 cells were PB-resistant.RAB25 and ESRP1 were identified as key regulators of PB sensitivity, while ANKD1, ETS1, PTRF, IFI16 and KIAA1199 acted ..
  45. Xue H, Qiao Y, Ni P, Wang J, Chen C, Huang G. A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene. Int J Biochem Cell Biol. 2011;43:348-57 pubmed publisher
    b>RAB25 plays an important role in tumor progression and aggressiveness; altered RAB25 expression may cause human cancer...
  46. Tellez Gabriel M, Arroyo Solera I, Leon X, Gallardo A, Lopez M, Céspedes M, et al. High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma. Cancer Med. 2013;2:950-63 pubmed publisher
    ..In a previous microarray study, RAB25 was identified as a potential prognostic marker...
  47. Brusegard K, Stavnes H, Nymoen D, Flatmark K, Trope C, Davidson B. Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma. Virchows Arch. 2012;460:193-202 pubmed publisher
    b>Rab25, an epithelial-specific member of the Rab family of small GTPases, was previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared to malignant mesothelioma using gene expression arrays...
  48. Lall P, Lindsay A, Hanscom S, Kecman T, Taglauer E, McVeigh U, et al. Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP). J Biol Chem. 2015;290:18817-32 pubmed publisher
    ..Rab11 and Rab25 are closely related small GTPases that bind to common effectors termed the Rab11 family of interacting proteins (..
  49. Mitra S, Federico L, Zhao W, Dennison J, Sarkar T, Zhang F, et al. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 2016;7:40252-40265 pubmed publisher
    ..Herein we demonstrate that Rab25, a key GTPase, mostly decorating the apical recycling endosome, is a dichotomous variable in breast cancer cell ..
  50. Fan Y, Wang L, Han X, Liu X, Ma H. Rab25 is responsible for phosphoinositide 3-kinase/AKT‑mediated cisplatin resistance in human epithelial ovarian cancer cells. Mol Med Rep. 2015;11:2173-8 pubmed publisher
    b>Rab25, a member of the Rab family of small guanosine triphosphatase, was reported to have an essential role in the development of human epithelial ovarian cancer...
  51. Prekeris R, Davies J, Scheller R. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem. 2001;276:38966-70 pubmed
    ..The data suggest that various Rab effectors compete with each other for binding to Rab11/25 possibly accounting for the diversity of Rab11 functions. ..
  52. Lindsay A, Jollivet F, Horgan C, Khan A, Raposo G, McCaffrey M, et al. Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell. 2013;24:3420-34 pubmed publisher
    ..We also present evidence that myosin Va is necessary for maintaining a peripheral distribution of Rab11- and Rab14-positive endosomes. ..
  53. Lapierre L, Goldenring J. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Methods Enzymol. 2005;403:715-23 pubmed
    ..DsRed2-myosin Vb tail in MDCK cell lines stably transfected with wild-type or dominant active forms of Rab11a or Rab25 demonstrated that the distribution of Rab25S21V is only partially altered by expression of the myosin Vb tail...
  54. Wang S, Hu C, Wu F, He S. Rab25 GTPase: Functional roles in cancer. Oncotarget. 2017;8:64591-64599 pubmed publisher
    b>Rab25, a small GTPase belongs to the Rab protein family, has a pivotal role in cancer pathophysiology...
  55. Geng D, Zhao W, Feng Y, Liu J. Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion. Tumour Biol. 2016;37:7713-8 pubmed publisher
    b>Rab25 was reported to be associated with several human cancers and malignant biological behavior of cancer cells...
  56. Ding B, Cui B, Gao M, Li Z, Xu C, Fan S, et al. Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells. Oncol Res. 2017;25:331-340 pubmed publisher
    Ras-related protein 25 (Rab25) is a member of the Rab family, and it has been reported to play an important role in tumorigenesis. However, its direct involvement in human glioblastoma multiforme (GBM) is still unclear...
  57. Feng Z, Fang Y, Zhao L, Lu J, Wang Y, Chen Z, et al. RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25. Cancer Sci. 2017;108:1620-1627 pubmed publisher
    ..In addition, we unveil Rab25, a critical GTPase in ccRCC malignancy, as a functional RIN1 interacting partner...
  58. Gankhuyag N, Yu K, Davaadamdin O, Lee S, Cho W, Park C, et al. Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice. J Aerosol Med Pulm Drug Deliv. 2017;30:81-90 pubmed publisher
    b>Rab25, a member of Rab family of small guanosine triphosphatase, is associated with progression of various types of human cancers, including lung cancer, the leading cause of cancer-associated deaths around the globe...