Gene Symbol: RAB22A
Description: RAB22A, member RAS oncogene family
Alias: ras-related protein Rab-22A, GTP-binding protein RAB22A, rab-22
Species: human
Products:     RAB22A

Top Publications

  1. Weigert R, Yeung A, Li J, Donaldson J. Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Mol Biol Cell. 2004;15:3758-70 pubmed
    ..g., transferrin. Here, we show that the small GTPase Rab22a is associated with these tubular recycling intermediates containing MHCI...
  2. Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, et al. The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci. 2002;115:899-911 pubmed
    b>Rab22a is a small GTPase that is expressed ubiquitously in mammalian tissues and displays the highest sequence homology to Rab5...
  3. Eathiraj S, Pan X, Ritacco C, Lambright D. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005;436:415-9 pubmed
  4. Magadán J, Barbieri M, Mesa R, Stahl P, Mayorga L. Rab22a regulates the sorting of transferrin to recycling endosomes. Mol Cell Biol. 2006;26:2595-614 pubmed
    b>Rab22a is a member of the Rab family of small GTPases that localizes in the endocytic pathway. In CHO cells, expression of canine Rab22a (cRab22a) causes a dramatic enlargement of early endocytic compartments...
  5. Zheng S, Jiang F, Ge D, Tang J, Chen H, Yang J, et al. LncRNA SNHG3/miRNA-151a-3p/RAB22A axis regulates invasion and migration of osteosarcoma. Biomed Pharmacother. 2019;112:108695 pubmed publisher
    ..SNHG3 is highly expressed in osteosarcoma, and promotes the invasive and migratory potentials of osteosarcoma cells by absorbing miRNA-151a-3p to upregulate RAB22 A expression. ..
  6. Long N, Park S, Anh N, Min J, Yoon S, Kim H, et al. Efficacy of Integrating a Novel 16-Gene Biomarker Panel and Intelligence Classifiers for Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis. J Clin Med. 2019;8: pubmed publisher
    ..differentiate RA from OA, including TMOD1, POP7, SGCA, KLRD1, ALOX5, RAB22A, ANK3, PTPN3, GZMK, CLU, GZMB, FBXL7, TNFRSF4, IL32, <..
  7. Sun L, He M, Xu N, Xu D, Ben David Y, Yang Z, et al. Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes. Int J Oncol. 2018;53:2705-2714 pubmed publisher
    ..b>RAB22A, a member of the proto-oncogene RAS family, plays an important role in the formation, trafficking and metabolism ..
  8. Shakya S, Sharma P, Bhatt A, Jani R, Delevoye C, Setty S. Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. EMBO Rep. 2018;19: pubmed publisher
    ..In this study, by using an endosomal Rab-specific RNAi screen, we identified Rab22A as a critical player during RE biogenesis...
  9. Kang F, Zhu J, Wu J, Lv T, Xiang H, Tian J, et al. O2-3-Aminopropyl diazeniumdiolates suppress the progression of highly metastatic triple-negative breast cancer by inhibition of microvesicle formation via nitric oxide-based epigenetic regulation. Chem Sci. 2018;9:6893-6898 pubmed publisher
    ..of implanted TNBC in vivo through attenuating MV formation by an epigenetic modification of miR-203/RAB22A expression in an NO-dependent manner, providing the first evidence of NO donor(s) acting as epigenetic ..

More Information


  1. Holloway Z, Velayos Baeza A, Howell G, Levecque C, Ponnambalam S, Sztul E, et al. Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps. Mol Biol Cell. 2013;24:1735-48, S1-8 pubmed publisher
    ..We assess the role of clathrin, adaptor complexes, lipid rafts, and Rab22a in an attempt to decipher the regulatory proteins involved in ATP7A cycling...
  2. Glantz M, Gustavsson F, Bertelsen H, Stålhammar H, Lindmark Månsson H, Paulsson M, et al. Bovine chromosomal regions affecting rheological traits in acid-induced skim milk gels. J Dairy Sci. 2015;98:1273-85 pubmed publisher
    ..significant QTL comprising the 2 milk proteins, 3 additional genes are proposed as possible candidates, namely RAB22A, CDH13, and STAT1, and all have previously been found to be expressed in the mammary gland...
  3. Mayorga L, Cebrian I. Rab22a: A novel regulator of immune functions. Mol Immunol. 2018;: pubmed publisher
    ..In this review, we synthesize and update the current knowledge about Rab22a, which has been involved in several immune functions...
  4. Wang X, Wu Y, Wang D, Qin Z. MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer. Genet Mol Res. 2014;13:8695-703 pubmed publisher
    ..Among the target genes, 5 (RAB22A, SOX4, IKZF2, PLAG1, and BTBD7) were of interest because they can be simultaneously regulated by several DEMs...
  5. Barrile R, Kasendra M, Rossi Paccani S, Merola M, Pizza M, Baldari C, et al. Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier. Cell Microbiol. 2015;17:1365-75 pubmed publisher
    ..endosomal compartments was evaluated through the concomitant staining of bacteria and markers specific for Rab11, Rab22a, Rab25 and Rab3 followed by confocal microscopy imaging...
  6. Karleuša L, Mahmutefendić H, Tomaš M, Zagorac G, Lučin P. Landmarks of endosomal remodeling in the early phase of cytomegalovirus infection. Virology. 2018;515:108-122 pubmed publisher
    ..Internalized cargo accumulates in Arf6-, Rab5-, Rab22A-, and Rab11-positive and Rab35-, Rab8-, and Rab10-negative juxtanuclear endosomes, suggesting the disruption of ..
  7. Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep. 2016;6:23892 pubmed publisher
    ..The present work provides the first evidence of a UCA1-miR-204-5p-CREB1/BCL2/RAB22A regulatory network in CRC and reveals that UCA1 and CREB1 are potential new oncogenes and prognostic factors for ..
  8. Xia Z, Liu F, Zhang J, Liu L. Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion. PLoS ONE. 2015;10:e0132399 pubmed publisher
    ..Furthermore, mechanistic investigations revealed that RAB22A, a member of the RAS oncogene family, is a direct functional target of miR-204-5p in gliomas...
  9. Johnson D, Wayt J, Wilson J, Donaldson J. Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking. J Cell Sci. 2017;130:2405-2415 pubmed publisher
    ..In Jurkat cells, the activities of two guanine nucleotide binding proteins, Arf6 and Rab22 (also known as Rab22a), influence CIE and conjugate formation...
  10. Qu F, LORENZO D, King S, Brooks R, Bear J, Bennett V. Ankyrin-B is a PI3P effector that promotes polarized ?5?1-integrin recycling via recruiting RabGAP1L to early endosomes. elife. 2016;5: pubmed publisher
    ..Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts...
  11. Hsiao J, Chu L, Lo Y, Lee S, Chen T, Huang C, et al. Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22. J Virol. 2015;89:8365-82 pubmed publisher
    ..There, the complex executes endosomal membrane fission and cargo sorting to the Rab11-positive and Rab22-positive recycling pathway, resulting in membrane fusion and virus core uncoating in the cytoplasm. ..
  12. Bao S, Zhu J, Garvey W. Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. Horm Metab Res. 1998;30:656-62 pubmed
    ..The potential role of specific Rab isoforms in insulin resistance does not rely on a change in steady state mRNA levels, but is demonstrable as an alteration in protein subcellular distribution and trafficking. ..
  13. Zhu H, Liang Z, Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol Biol Cell. 2009;20:4720-9 pubmed publisher
    ..This novel Rab22-Rabex-5-Rab5 cascade is functionally important for the endocytosis and degradation of epidermal growth factor. ..
  14. Wang T, Gilkes D, Takano N, Xiang L, Luo W, Bishop C, et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2014;111:E3234-42 pubmed publisher
    ..cancer cells to hypoxia augments MV shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface...
  15. Yang Z, He M, Wang K, Sun G, Tang L, Xu Z. Tumor suppressive microRNA-193b promotes breast cancer progression via targeting DNAJC13 and RAB22A. Int J Clin Exp Pathol. 2014;7:7563-70 pubmed
    ..By using in silico prediction algorithms approach for target identification, we identified DNAJC13 (HPS40) and RAB22A to be direct targets of miR-193b...
  16. Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni C. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). Biochem Biophys Res Commun. 1999;258:657-62 pubmed
    ..Analysis of mRNA expression shows a single abundant mRNA of about 0.8 kb ubiquitously expressed. Western blot analysis of the overexpressed protein shows a band of the expected size equally distributed between cytosol and membranes. ..
  17. Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011;12:407-20 pubmed publisher
    ..tb-containing phagosomes is involved in arresting phagosome maturation and inhibiting phagolysosome biogenesis. ..
  18. Yin Y, Zhang B, Wang W, Fei B, Quan C, Zhang J, et al. miR-204-5p inhibits proliferation and invasion and enhances chemotherapeutic sensitivity of colorectal cancer cells by downregulating RAB22A. Clin Cancer Res. 2014;20:6187-99 pubmed publisher
    ..Mechanistic investigations revealed that RAB22A, a member of the RAS oncogene family, is a direct functional target of miR-204-5p in colorectal cancer...
  19. Cebrian I, Croce C, Guerrero N, Blanchard N, Mayorga L. Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 2016;17:1753-1765 pubmed
    ..In this work, we identify the small GTPase Rab22a as a key regulator of MHC-I trafficking and antigen cross-presentation by DCs...
  20. Zhang Z, Cheng J, Wu Y, Qiu J, Sun Y, Tong X. LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer. Mol Med Rep. 2016;14:2465-72 pubmed publisher
    ..HOTAIR functioned as a ceRNA, and acted as a sink for microRNA (miR)?373, thereby regulating the expression of Rab22a. The upregulation of HOTAIR contributed to the malignant progression of ovarian cancer cells...
  21. Yu H, Yang W. MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A. Biochem Biophys Res Commun. 2016;476:400-405 pubmed publisher
    ..By performing bioinformatics analysis, we found that RAB22A is a possible target of miR-211, which has two broadly conversed binding sites with miR-211 in the 3'UTR...
  22. Su F, Chen Y, Zhu S, Li F, Zhao S, Wu L, et al. RAB22A overexpression promotes the tumor growth of melanoma. Oncotarget. 2016;7:71744-71753 pubmed publisher
    Malignant melanoma is the most aggressive type of skin cancer. RAB22A, a member of RAS oncogene family, has been found to be significantly upregulated in multiple human cancers...
  23. Zhou Y, Wu B, Li J, Nan G, Jiang J, Chen Z. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion. Exp Cell Res. 2017;357:9-16 pubmed publisher
    b>Rab22a is a member of the Ras-related small GTPase family, which plays a key role in regulating the recycling of cargo proteins entering cells through clathrin-independent endocytosis (CIE)...
  24. Mesa R, Magadán J, Barbieri A, Lopez C, Stahl P, Mayorga L. Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus. Exp Cell Res. 2005;304:339-53 pubmed
    ..b>Rab22a has been localized to the endocytic compartment; however, very little is known about the function of Rab22a and ..
  25. Naj X, Linder S. ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages. Cell Rep. 2015;12:1816-30 pubmed publisher
    ..We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles...
  26. Quevedo M, Lucchesi O, Bustos M, Pocognoni C, De la Iglesia P, Tomes C. The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores. J Biol Chem. 2016;291:23101-23111 pubmed
    ..Complexes are disentangled by these chaperons to achieve vesiculation and acrosomal contents release. Thus, post-fusion regulation of the pores determines their expansion and the success of the acrosome reaction. ..
  27. Zhang Y, Zhao F, Chen L, Wang L, Nephew K, Wu Y, et al. MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer. Oncotarget. 2014;5:12291-303 pubmed
    ..Using integrated bioinformatics analysis, gene expression arrays, and luciferase assay, we identified Rab22a as a direct and functional target of miR-373 in EOC cells...
  28. Yuan F, Snapp E, Novikoff P, Suadicani S, Spray D, Potvin B, et al. Human liver cell trafficking mutants: characterization and whole exome sequencing. PLoS ONE. 2014;9:e87043 pubmed publisher
    ..The novel mutation Ile34Phe in the GTPase RAB22A was identified in Trf4...
  29. Zhang B, Yin Y, Hu Y, Zhang J, Bian Z, Song M, et al. MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A. Med Oncol. 2015;32:331 pubmed publisher
    ..Subsequent mechanistic investigations identified that USP47 and RAB22A are direct functional targets of miR-204-5p in GC...
  30. Xiong F, Liu K, Zhang F, Sha K, Wang X, Guo X, et al. MiR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression. Oncol Rep. 2016;35:3000-8 pubmed publisher
    ..Mechanism dissection revealed that miR-204 may function through RAB22A signals to inhibit RCC proliferation and invasion...
  31. Yang D, Liu G, Wang K. miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A. PLoS ONE. 2015;10:e0132225 pubmed publisher
    ..Moreover, we identified RAB22A as a direct target of miR-203 and RAB22A overexpression blocks the roles of miR-203 in osteosarcoma cell...
  32. Opdam F, Kamps G, Croes H, van Bokhoven H, Ginsel L, Fransen J. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. Eur J Cell Biol. 2000;79:308-16 pubmed
    ..Seven novel human sequences, representing Rab2B, Rab6A', Rab6B, Rab10, Rab19B, Rab21 and Rab22A, were identified. For one clone, encoding Rab21, full-length cDNA was isolated from a Caco-2 cDNA library...